KCNN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.49076935
2cell migration in hindbrain (GO:0021535)4.44832399
3neuron cell-cell adhesion (GO:0007158)4.35533483
4pyrimidine nucleobase catabolic process (GO:0006208)4.31680526
5axon ensheathment in central nervous system (GO:0032291)4.30616397
6central nervous system myelination (GO:0022010)4.30616397
7cellular potassium ion homeostasis (GO:0030007)4.27298775
8positive regulation of dendritic spine development (GO:0060999)4.09130798
9protein localization to synapse (GO:0035418)4.05458940
10regulation of short-term neuronal synaptic plasticity (GO:0048172)4.03226654
11positive regulation of dendritic spine morphogenesis (GO:0061003)4.00462361
12regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.99341162
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.97038998
14neuron recognition (GO:0008038)3.95930934
15synaptic vesicle exocytosis (GO:0016079)3.91448720
16auditory behavior (GO:0031223)3.90470544
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.85303213
18glutamate secretion (GO:0014047)3.81332413
19regulation of neurotransmitter levels (GO:0001505)3.81311912
20regulation of voltage-gated calcium channel activity (GO:1901385)3.74632391
21layer formation in cerebral cortex (GO:0021819)3.72871946
22sodium ion export (GO:0071436)3.72492901
23positive regulation of membrane potential (GO:0045838)3.71620386
24neuronal action potential propagation (GO:0019227)3.70937956
25L-amino acid import (GO:0043092)3.67649630
26axonal fasciculation (GO:0007413)3.67310577
27vocalization behavior (GO:0071625)3.67236862
28regulation of synaptic vesicle exocytosis (GO:2000300)3.58821888
29dendritic spine morphogenesis (GO:0060997)3.56776235
30regulation of neurotransmitter transport (GO:0051588)3.56528504
31positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.54135163
32nucleobase catabolic process (GO:0046113)3.45974540
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.44082987
34regulation of synaptic vesicle transport (GO:1902803)3.43750421
35synaptic vesicle maturation (GO:0016188)3.43368744
36positive regulation of neurotransmitter transport (GO:0051590)3.41556483
37membrane depolarization during action potential (GO:0086010)3.40251887
38establishment of mitochondrion localization (GO:0051654)3.39170071
39dendrite morphogenesis (GO:0048813)3.39141416
40dendritic spine organization (GO:0097061)3.37745211
41regulation of dendritic spine development (GO:0060998)3.35764618
42cerebellar granule cell differentiation (GO:0021707)3.34065591
43regulation of glutamate receptor signaling pathway (GO:1900449)3.28518363
44regulation of synapse maturation (GO:0090128)3.28388661
45regulation of synaptic plasticity (GO:0048167)3.28171825
46regulation of cell communication by electrical coupling (GO:0010649)3.25667255
47response to auditory stimulus (GO:0010996)3.23982264
48neuromuscular process controlling balance (GO:0050885)3.20822005
49serotonin metabolic process (GO:0042428)3.20200595
50positive regulation of neurotransmitter secretion (GO:0001956)3.19656304
51regulation of vesicle fusion (GO:0031338)3.18158008
52potassium ion import (GO:0010107)3.14272446
53cerebellar Purkinje cell differentiation (GO:0021702)3.14207342
54* synaptic transmission (GO:0007268)3.14144659
55amino acid import (GO:0043090)3.13517451
56proline transport (GO:0015824)3.12926068
57acidic amino acid transport (GO:0015800)3.12715401
58behavioral defense response (GO:0002209)3.12486445
59behavioral fear response (GO:0001662)3.12486445
60prepulse inhibition (GO:0060134)3.11367926
61regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.10028496
62establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.08118559
63mitochondrion transport along microtubule (GO:0047497)3.08118559
64potassium ion homeostasis (GO:0055075)3.07727673
65phosphorelay signal transduction system (GO:0000160)3.07611050
66neurotransmitter secretion (GO:0007269)3.07206318
67gamma-aminobutyric acid signaling pathway (GO:0007214)3.06440540
68neuronal action potential (GO:0019228)3.06315722
69neurotransmitter-gated ion channel clustering (GO:0072578)3.05894358
70presynaptic membrane organization (GO:0097090)3.05878728
71presynaptic membrane assembly (GO:0097105)3.05688152
72regulation of synaptic transmission, glutamatergic (GO:0051966)3.05661228
73primary amino compound metabolic process (GO:1901160)3.05322904
74long-term memory (GO:0007616)3.05218048
75mechanosensory behavior (GO:0007638)3.04132715
76regulation of synapse structural plasticity (GO:0051823)3.03965080
77synaptic vesicle docking involved in exocytosis (GO:0016081)3.03844669
78fear response (GO:0042596)3.02937868
79neuromuscular process controlling posture (GO:0050884)3.02725138
80adult walking behavior (GO:0007628)3.01011062
81regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.00990229
82negative regulation of microtubule polymerization (GO:0031115)3.00966831
83regulation of synaptic transmission (GO:0050804)3.00578946
84G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.00161637
85neurofilament cytoskeleton organization (GO:0060052)2.96125155
86synaptic transmission, glutamatergic (GO:0035249)2.94172258
87regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.92669336
88detection of calcium ion (GO:0005513)2.92213503
89sarcoplasmic reticulum calcium ion transport (GO:0070296)2.89477589
90positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.89290354
91locomotory exploration behavior (GO:0035641)2.88978471
92ionotropic glutamate receptor signaling pathway (GO:0035235)2.87202700
93negative regulation of dendrite development (GO:2000171)2.85639605
94postsynaptic membrane organization (GO:0001941)2.85150537
95positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.84837073
96neuron-neuron synaptic transmission (GO:0007270)2.82116204
97regulation of neuronal synaptic plasticity (GO:0048168)2.81281246
98synaptic vesicle endocytosis (GO:0048488)2.81039819
99gamma-aminobutyric acid transport (GO:0015812)2.80047224
100glutamate receptor signaling pathway (GO:0007215)2.78040021
101positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.77498588
102response to pheromone (GO:0019236)2.76811334
103regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.76184930
104transmission of nerve impulse (GO:0019226)2.75103128
105detection of temperature stimulus involved in sensory perception (GO:0050961)2.74793629
106detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.74793629
107cell communication involved in cardiac conduction (GO:0086065)2.73643727
108cell communication by electrical coupling (GO:0010644)2.71836666
109membrane depolarization (GO:0051899)2.71514869
110regulation of membrane repolarization (GO:0060306)2.69953043
111behavioral response to cocaine (GO:0048148)2.69662389
112negative regulation of dendrite morphogenesis (GO:0050774)2.68199564
113negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.67067390
114calcium-mediated signaling using intracellular calcium source (GO:0035584)2.66695768
115axon extension (GO:0048675)2.66272437
116innervation (GO:0060384)2.66168722
117central nervous system projection neuron axonogenesis (GO:0021952)2.65395563
118regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.65360066
119neuronal ion channel clustering (GO:0045161)2.65213291
120synapse assembly (GO:0007416)2.63996405
121regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.63812106
122regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.63129652
123neuromuscular synaptic transmission (GO:0007274)2.62412934
124positive regulation of synapse maturation (GO:0090129)2.61826648
125hippocampus development (GO:0021766)2.61717749
126regulation of excitatory postsynaptic membrane potential (GO:0060079)2.58777723
127regulation of respiratory system process (GO:0044065)2.57281548
128regulation of neurotransmitter secretion (GO:0046928)2.54983455
129cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.54870627
130detection of temperature stimulus (GO:0016048)2.54400814
131neurotransmitter transport (GO:0006836)2.53711051
132synapse organization (GO:0050808)2.53528524
133regulation of postsynaptic membrane potential (GO:0060078)2.52895343
134negative regulation of axonogenesis (GO:0050771)2.51460230
135positive regulation of synapse assembly (GO:0051965)2.50432128
136regulation of long-term neuronal synaptic plasticity (GO:0048169)2.49992849
137mating behavior (GO:0007617)2.49629964
138G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.49549575
139exploration behavior (GO:0035640)2.49353043
140positive regulation of synaptic transmission, GABAergic (GO:0032230)2.47927941
141regulation of dendritic spine morphogenesis (GO:0061001)2.47883696
142regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.47486056
143negative regulation of synaptic transmission, GABAergic (GO:0032229)2.47168522

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.39208714
2GBX2_23144817_ChIP-Seq_PC3_Human3.37234876
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99585054
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97076634
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.95298161
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.82177558
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72920071
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72920071
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.70190382
10EZH2_27294783_Chip-Seq_ESCs_Mouse2.48880532
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46165656
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45194729
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.39979001
14REST_21632747_ChIP-Seq_MESCs_Mouse2.39488563
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.37280451
16* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33146300
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32784963
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30223737
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18592831
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.18505790
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.17795848
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.12208900
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.97631354
24DROSHA_22980978_ChIP-Seq_HELA_Human1.92875382
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.89010816
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80600210
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74038998
28RARB_27405468_Chip-Seq_BRAIN_Mouse1.74037252
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.73744118
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.71715617
31TAF15_26573619_Chip-Seq_HEK293_Human1.69311488
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.60147974
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57552305
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56339132
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55383218
36IGF1R_20145208_ChIP-Seq_DFB_Human1.51581745
37AR_21572438_ChIP-Seq_LNCaP_Human1.49533368
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44964734
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44884888
40CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.43960732
41VDR_22108803_ChIP-Seq_LS180_Human1.43501395
42RING1B_27294783_Chip-Seq_ESCs_Mouse1.42573313
43RNF2_27304074_Chip-Seq_NSC_Mouse1.40924027
44ZNF274_21170338_ChIP-Seq_K562_Hela1.39261402
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37957753
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31088541
47* RING1B_27294783_Chip-Seq_NPCs_Mouse1.29256929
48P300_19829295_ChIP-Seq_ESCs_Human1.29032664
49ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.28938428
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28637066
51SMAD4_21799915_ChIP-Seq_A2780_Human1.26875832
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25902837
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20310308
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19684987
55SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19593274
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.18080400
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17073251
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.15050834
59* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14959793
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14743144
61TP53_20018659_ChIP-ChIP_R1E_Mouse1.12409561
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.11459254
63CTCF_27219007_Chip-Seq_Bcells_Human1.10113001
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09677313
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07346042
66GATA1_26923725_Chip-Seq_HPCs_Mouse1.07236083
67AR_19668381_ChIP-Seq_PC3_Human1.06853754
68POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03119655
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03119655
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02537196
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02302767
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02228699
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02110915
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00866198
75STAT3_23295773_ChIP-Seq_U87_Human0.99126439
76AHR_22903824_ChIP-Seq_MCF-7_Human0.98634752
77* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97373719
78NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96855446
79OCT4_19829295_ChIP-Seq_ESCs_Human0.95821993
80SMAD4_21741376_ChIP-Seq_HESCs_Human0.95580061
81* KDM2B_26808549_Chip-Seq_K562_Human0.94481985
82BCAT_22108803_ChIP-Seq_LS180_Human0.93795474
83ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93721118
84AR_25329375_ChIP-Seq_VCAP_Human0.93115856
85TET1_21490601_ChIP-Seq_MESCs_Mouse0.91826910
86DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91658375
87RUNX2_22187159_ChIP-Seq_PCA_Human0.91552066
88WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90889105
89* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90822234
90NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90685405
91ARNT_22903824_ChIP-Seq_MCF-7_Human0.89886374
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89766300
93MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89719318
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88980130
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88539354
96EP300_21415370_ChIP-Seq_HL-1_Mouse0.88283734
97* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88275184
98TCF4_23295773_ChIP-Seq_U87_Human0.87918725
99ER_23166858_ChIP-Seq_MCF-7_Human0.86388154
100YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86225536
101ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85479006
102JUN_21703547_ChIP-Seq_K562_Human0.83027805
103IKZF1_21737484_ChIP-ChIP_HCT116_Human0.82406203
104* SMAD3_21741376_ChIP-Seq_ESCs_Human0.82168127
105* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82109490
106EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.81744750
107STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.81434350
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.79797585
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.79316482
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79179965
111* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.79174548
112FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.78629339
113CBP_20019798_ChIP-Seq_JUKART_Human0.78364567
114SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76275252
115DPY_21335234_ChIP-Seq_ESCs_Mouse0.75327550
116MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.74688235
117KLF4_19829295_ChIP-Seq_ESCs_Human0.74568531
118SOX9_26525672_Chip-Seq_HEART_Mouse0.71072440
119MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.71009209
120ETV2_25802403_ChIP-Seq_MESCs_Mouse0.70654157
121SRY_22984422_ChIP-ChIP_TESTIS_Rat0.70507593

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.60760181
2MP0004859_abnormal_synaptic_plasticity3.90808645
3MP0004270_analgesia3.80470891
4MP0001968_abnormal_touch/_nociception3.18290761
5MP0006276_abnormal_autonomic_nervous3.05120626
6MP0002734_abnormal_mechanical_nocicepti2.83764137
7MP0003635_abnormal_synaptic_transmissio2.77366912
8MP0002736_abnormal_nociception_after2.75722529
9MP0003787_abnormal_imprinting2.72415745
10MP0002735_abnormal_chemical_nociception2.70616719
11MP0002837_dystrophic_cardiac_calcinosis2.58974888
12MP0000751_myopathy2.33211919
13MP0002063_abnormal_learning/memory/cond2.32361416
14MP0000778_abnormal_nervous_system2.30247401
15MP0009745_abnormal_behavioral_response2.24041967
16MP0005423_abnormal_somatic_nervous2.21536113
17MP0002733_abnormal_thermal_nociception2.20913719
18MP0002272_abnormal_nervous_system2.15901738
19MP0002064_seizures2.12692235
20MP0001486_abnormal_startle_reflex2.04508424
21MP0004858_abnormal_nervous_system1.97448639
22MP0001970_abnormal_pain_threshold1.96253208
23MP0009046_muscle_twitch1.92687930
24MP0002184_abnormal_innervation1.91310920
25MP0002572_abnormal_emotion/affect_behav1.91042839
26MP0002067_abnormal_sensory_capabilities1.79285441
27MP0003646_muscle_fatigue1.77246158
28MP0001440_abnormal_grooming_behavior1.66366653
29MP0000955_abnormal_spinal_cord1.66196729
30MP0003122_maternal_imprinting1.65042588
31MP0004145_abnormal_muscle_electrophysio1.62955431
32MP0003137_abnormal_impulse_conducting1.57616157
33MP0003123_paternal_imprinting1.54347689
34MP0008877_abnormal_DNA_methylation1.52218520
35MP0001529_abnormal_vocalization1.50484779
36MP0001984_abnormal_olfaction1.50478360
37MP0004215_abnormal_myocardial_fiber1.44896914
38MP0002653_abnormal_ependyma_morphology1.41756537
39MP0004142_abnormal_muscle_tone1.41034155
40MP0000749_muscle_degeneration1.40945854
41MP0002882_abnormal_neuron_morphology1.40575163
42MP0004811_abnormal_neuron_physiology1.39700177
43MP0002557_abnormal_social/conspecific_i1.37279523
44MP0003329_amyloid_beta_deposits1.36498681
45MP0005386_behavior/neurological_phenoty1.35821453
46MP0004924_abnormal_behavior1.35821453
47MP0005167_abnormal_blood-brain_barrier1.26210021
48MP0002066_abnormal_motor_capabilities/c1.26168747
49MP0005645_abnormal_hypothalamus_physiol1.20451871
50MP0003121_genomic_imprinting1.18494647
51MP0001905_abnormal_dopamine_level1.17076480
52MP0004130_abnormal_muscle_cell1.15695943
53MP0002909_abnormal_adrenal_gland1.15614250
54MP0004085_abnormal_heartbeat1.15169856
55MP0002752_abnormal_somatic_nervous1.09574493
56MP0002638_abnormal_pupillary_reflex1.08715636
57MP0008872_abnormal_physiological_respon1.07537036
58MP0001501_abnormal_sleep_pattern1.07273192
59MP0006292_abnormal_olfactory_placode1.06477452
60MP0009780_abnormal_chondrocyte_physiolo1.06255003
61MP0001502_abnormal_circadian_rhythm1.05794288
62MP0000569_abnormal_digit_pigmentation1.04498104
63MP0005551_abnormal_eye_electrophysiolog1.04146370
64MP0002152_abnormal_brain_morphology1.00944448
65MP0008569_lethality_at_weaning1.00075533
66MP0004147_increased_porphyrin_level0.99899177
67MP0005620_abnormal_muscle_contractility0.99458287
68MP0004133_heterotaxia0.98254809
69MP0001485_abnormal_pinna_reflex0.98155613
70MP0004036_abnormal_muscle_relaxation0.97734786
71MP0003283_abnormal_digestive_organ0.97624393
72MP0001177_atelectasis0.97612745
73MP0002751_abnormal_autonomic_nervous0.96564059
74MP0005535_abnormal_body_temperature0.95565262
75MP0002229_neurodegeneration0.92398966
76MP0003690_abnormal_glial_cell0.91676730
77MP0000747_muscle_weakness0.88960714
78MP0002822_catalepsy0.88720879
79MP0004885_abnormal_endolymph0.86570909
80MP0000759_abnormal_skeletal_muscle0.86341446
81MP0004742_abnormal_vestibular_system0.85563290
82MP0004233_abnormal_muscle_weight0.84973117
83MP0002069_abnormal_eating/drinking_beha0.84311106
84MP0002106_abnormal_muscle_physiology0.83216547
85MP0005394_taste/olfaction_phenotype0.82149437
86MP0005499_abnormal_olfactory_system0.82149437
87MP0005083_abnormal_biliary_tract0.82009992
88MP0002269_muscular_atrophy0.81773830
89MP0005646_abnormal_pituitary_gland0.80225409
90MP0002972_abnormal_cardiac_muscle0.78514533
91MP0003634_abnormal_glial_cell0.78373809
92MP0004087_abnormal_muscle_fiber0.78153224
93MP0000631_abnormal_neuroendocrine_gland0.77925325
94MP0001348_abnormal_lacrimal_gland0.77870865
95MP0002139_abnormal_hepatobiliary_system0.77714568
96MP0004484_altered_response_of0.77633627
97MP0003938_abnormal_ear_development0.77593195
98MP0003631_nervous_system_phenotype0.76099772
99MP0001963_abnormal_hearing_physiology0.76000327
100MP0005085_abnormal_gallbladder_physiolo0.75485636
101MP0005330_cardiomyopathy0.75287103
102MP0003633_abnormal_nervous_system0.75125929
103MP0003879_abnormal_hair_cell0.74084983
104MP0005369_muscle_phenotype0.73070126
105MP0000026_abnormal_inner_ear0.72989198
106MP0003861_abnormal_nervous_system0.72979845
107MP0010386_abnormal_urinary_bladder0.72724472
108MP0001986_abnormal_taste_sensitivity0.72381438
109MP0002163_abnormal_gland_morphology0.72235255
110MP0000920_abnormal_myelination0.71012753
111MP0004084_abnormal_cardiac_muscle0.70362955
112MP0001188_hyperpigmentation0.69764634
113MP0001299_abnormal_eye_distance/0.68829997
114MP0009379_abnormal_foot_pigmentation0.67010120
115MP0002102_abnormal_ear_morphology0.65928546
116MP0003632_abnormal_nervous_system0.64771721
117MP0005187_abnormal_penis_morphology0.64401145
118MP0006072_abnormal_retinal_apoptosis0.63361401
119MP0002160_abnormal_reproductive_system0.62471452
120MP0002876_abnormal_thyroid_physiology0.61087526
121MP0008874_decreased_physiological_sensi0.60455132
122MP0003119_abnormal_digestive_system0.60019701
123MP0005253_abnormal_eye_physiology0.59609461
124MP0001346_abnormal_lacrimal_gland0.59272455
125MP0005379_endocrine/exocrine_gland_phen0.57301110
126MP0002234_abnormal_pharynx_morphology0.55981059
127MP0003183_abnormal_peptide_metabolism0.55498344
128MP0005195_abnormal_posterior_eye0.52849404

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.56664411
2Myokymia (HP:0002411)4.55551641
3Abnormality of binocular vision (HP:0011514)3.81016461
4Diplopia (HP:0000651)3.81016461
5Focal seizures (HP:0007359)3.63126347
6Supranuclear gaze palsy (HP:0000605)3.49168690
7Atonic seizures (HP:0010819)3.40064162
8Exercise-induced myalgia (HP:0003738)3.38706873
9Epileptic encephalopathy (HP:0200134)3.38471610
10Muscle hypertrophy of the lower extremities (HP:0008968)3.19884639
11Sudden death (HP:0001699)3.15552347
12Ankle clonus (HP:0011448)3.15148333
13Febrile seizures (HP:0002373)3.12313123
14Calf muscle hypertrophy (HP:0008981)3.01714982
15Hemiparesis (HP:0001269)2.87005328
16Abnormality of the corticospinal tract (HP:0002492)2.84738866
17Visual hallucinations (HP:0002367)2.83068944
18Broad-based gait (HP:0002136)2.82692085
19Failure to thrive in infancy (HP:0001531)2.82306061
20Hyperventilation (HP:0002883)2.81544576
21Absence seizures (HP:0002121)2.79329012
22Polyphagia (HP:0002591)2.75197809
23Status epilepticus (HP:0002133)2.74259372
24Cerebral hypomyelination (HP:0006808)2.71457750
25Intention tremor (HP:0002080)2.70490150
26Annular pancreas (HP:0001734)2.70265365
27Progressive cerebellar ataxia (HP:0002073)2.68837244
28Pheochromocytoma (HP:0002666)2.65141822
29Termporal pattern (HP:0011008)2.64872506
30Insidious onset (HP:0003587)2.64872506
31Generalized tonic-clonic seizures (HP:0002069)2.62720686
32Postural instability (HP:0002172)2.62636322
33Dialeptic seizures (HP:0011146)2.61842737
34Papilledema (HP:0001085)2.60047540
35Mutism (HP:0002300)2.56808553
36Impaired vibration sensation in the lower limbs (HP:0002166)2.54340480
37Amblyopia (HP:0000646)2.53040152
38Spastic gait (HP:0002064)2.49865901
39Hemiplegia (HP:0002301)2.49836877
40Spastic tetraparesis (HP:0001285)2.42798399
41Abnormal eating behavior (HP:0100738)2.42643404
42Urinary urgency (HP:0000012)2.40278708
43Abnormality of the calf musculature (HP:0001430)2.38268514
44Action tremor (HP:0002345)2.36205944
45Truncal ataxia (HP:0002078)2.34576339
46Myoglobinuria (HP:0002913)2.31143526
47Urinary bladder sphincter dysfunction (HP:0002839)2.31044174
48Genetic anticipation (HP:0003743)2.27148995
49Muscle fiber splitting (HP:0003555)2.27127316
50Prolonged QT interval (HP:0001657)2.26417014
51Gait imbalance (HP:0002141)2.26216096
52Hyporeflexia of lower limbs (HP:0002600)2.25385559
53Craniofacial dystonia (HP:0012179)2.24521925
54Sleep apnea (HP:0010535)2.23540971
55Impaired smooth pursuit (HP:0007772)2.21731117
56Myotonia (HP:0002486)2.19741463
57Fetal akinesia sequence (HP:0001989)2.18722876
58Lower limb muscle weakness (HP:0007340)2.17874831
59Abnormality of the lower motor neuron (HP:0002366)2.17746025
60Neuroendocrine neoplasm (HP:0100634)2.16622183
61Dysdiadochokinesis (HP:0002075)2.15627123
62Tetraplegia (HP:0002445)2.15551333
63Exercise-induced muscle cramps (HP:0003710)2.14984463
64Clonus (HP:0002169)2.14743904
65EMG: myopathic abnormalities (HP:0003458)2.13547435
66Incomplete penetrance (HP:0003829)2.12080034
67Anxiety (HP:0000739)2.12030307
68Shoulder girdle muscle weakness (HP:0003547)2.11580417
69Cerebral inclusion bodies (HP:0100314)2.10908376
70Epileptiform EEG discharges (HP:0011182)2.10506188
71Degeneration of the lateral corticospinal tracts (HP:0002314)2.10116972
72Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.10116972
73Esotropia (HP:0000565)2.08808961
74Hypoplasia of the brainstem (HP:0002365)2.08533687
75Aplasia/Hypoplasia of the brainstem (HP:0007362)2.08533687
76Type II lissencephaly (HP:0007260)2.07801364
77Abnormality of pain sensation (HP:0010832)2.07432113
78Impaired pain sensation (HP:0007328)2.07432113
79Depression (HP:0000716)2.06142111
80Abnormality of glycolysis (HP:0004366)2.05966374
81Increased serum pyruvate (HP:0003542)2.05966374
82EEG with generalized epileptiform discharges (HP:0011198)2.05149024
83Dysmetria (HP:0001310)2.04916424
84Bradykinesia (HP:0002067)2.04468279
85Akinesia (HP:0002304)2.04221081
86Difficulty running (HP:0009046)2.03759878
87Medial flaring of the eyebrow (HP:0010747)2.03549841
88Acute necrotizing encephalopathy (HP:0006965)2.03042540
89CNS hypomyelination (HP:0003429)2.03039551
90Poor eye contact (HP:0000817)2.02673312
91Drooling (HP:0002307)2.01786152
92Excessive salivation (HP:0003781)2.01786152
93Spastic tetraplegia (HP:0002510)2.01188516
94Abnormal mitochondria in muscle tissue (HP:0008316)2.00425803
95Hypsarrhythmia (HP:0002521)2.00392703
96Abnormal EKG (HP:0003115)1.99922776
97Ventricular fibrillation (HP:0001663)1.98333388
98Syncope (HP:0001279)1.94352157
99Megalencephaly (HP:0001355)1.93604838
100Abnormality of ocular smooth pursuit (HP:0000617)1.93111366
101Agitation (HP:0000713)1.92364142
102Neurofibrillary tangles (HP:0002185)1.89506039
103Oligomenorrhea (HP:0000876)1.89462080
104Abnormal hair whorl (HP:0010721)1.87864059
105Gaze-evoked nystagmus (HP:0000640)1.86454157
106Limb dystonia (HP:0002451)1.86255704
107Morphological abnormality of the pyramidal tract (HP:0002062)1.86241098
108Muscle fiber inclusion bodies (HP:0100299)1.85522940
109Abnormality of the labia minora (HP:0012880)1.85492280
110Inability to walk (HP:0002540)1.85435804
111Athetosis (HP:0002305)1.85211198
112Amyotrophic lateral sclerosis (HP:0007354)1.85139061
113Neuronal loss in central nervous system (HP:0002529)1.84438864
114Central scotoma (HP:0000603)1.83660299
115Bundle branch block (HP:0011710)1.83610545
116Abnormal social behavior (HP:0012433)1.83583866
117Impaired social interactions (HP:0000735)1.83583866
118Retinal dysplasia (HP:0007973)1.83511588
119Progressive macrocephaly (HP:0004481)1.80852367
120Muscle stiffness (HP:0003552)1.80811168
121Torticollis (HP:0000473)1.79897385
122Delusions (HP:0000746)1.79281142
123Hypoventilation (HP:0002791)1.78881097
124Impaired vibratory sensation (HP:0002495)1.78188411
125Lissencephaly (HP:0001339)1.77814022
126Absent speech (HP:0001344)1.77336008
127Acute encephalopathy (HP:0006846)1.77314001
128Focal dystonia (HP:0004373)1.75872749
129Pancreatic fibrosis (HP:0100732)1.75784192
130Nephronophthisis (HP:0000090)1.75575011
131Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.74832676
132Anosmia (HP:0000458)1.74572876
133Peripheral hypomyelination (HP:0007182)1.74392394
134Stereotypic behavior (HP:0000733)1.73894247
135Hypoplasia of the corpus callosum (HP:0002079)1.73796252
136True hermaphroditism (HP:0010459)1.73461025
137Ulnar claw (HP:0001178)1.73363437
138Primary atrial arrhythmia (HP:0001692)1.72051157
139Narrow nasal bridge (HP:0000446)1.71190575
140Specific learning disability (HP:0001328)1.71171099
141Split foot (HP:0001839)1.70155111
142Choreoathetosis (HP:0001266)1.70115306
143Molar tooth sign on MRI (HP:0002419)1.65796695
144Abnormality of midbrain morphology (HP:0002418)1.65796695
145Pancreatic cysts (HP:0001737)1.62355803
146Thyroid-stimulating hormone excess (HP:0002925)1.60515144
147Intellectual disability, severe (HP:0010864)1.60131218

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.19314624
2MAP3K93.08039052
3PHKG12.73042416
4PHKG22.73042416
5CASK2.67104245
6MAP3K42.63784659
7NTRK32.57029974
8EPHA42.38363739
9MINK12.28573844
10MAP2K72.25511700
11CAMKK12.21993558
12PAK62.17153722
13MAP2K41.92010275
14MAPK131.88169237
15DAPK21.87883618
16NTRK21.85690922
17UHMK11.74729573
18CDK191.67576068
19NME11.61718045
20KSR11.45323231
21GRK51.43465673
22NTRK11.41114502
23DYRK21.40640257
24PRPF4B1.36187844
25BCR1.33933387
26STK391.32371125
27TNIK1.29341018
28CDK51.27104422
29OXSR11.26974589
30EPHB21.24391906
31PAK31.24183308
32SIK21.23620190
33LMTK21.19331106
34CAMKK21.18358159
35PINK11.18279236
36PKN11.11089890
37OBSCN1.10161358
38CSNK1G21.09691157
39LIMK11.09115349
40KSR21.08643151
41SGK2231.07807179
42SGK4941.07807179
43TYRO31.05591553
44IRAK21.05222011
45MAP3K120.98099431
46PRKCG0.97256399
47PLK20.97222325
48CSNK1G30.97185808
49DYRK1A0.95371729
50CAMK2A0.92497697
51FGFR20.91462837
52MAP3K130.89942920
53CDK140.86941846
54MAP3K110.86282172
55STK380.85206296
56WNK40.82504533
57PNCK0.82490864
58INSRR0.82218439
59CDK180.81816469
60WNK30.81122577
61LATS20.80032768
62STK110.79733201
63CAMK2B0.79048197
64BMPR20.78028017
65BRAF0.77133878
66CDK150.76461736
67RET0.75639397
68CSNK1A1L0.75196411
69ROCK20.75160681
70ADRBK20.74356166
71CDC42BPA0.74297208
72FGR0.74145437
73CSNK1G10.73999141
74AKT30.73942620
75PRKD30.72536972
76FRK0.70948988
77MAPK120.70946359
78ROCK10.68987116
79CAMK2D0.68076160
80ICK0.66499941
81TTN0.66375255
82PRKCE0.66022124
83CDK11A0.65335536
84DAPK30.65166218
85SGK20.63530212
86DMPK0.61743205
87CAMK2G0.60338028
88FER0.60297810
89MARK20.58726432
90SGK30.58166027
91NEK10.58090656
92ALK0.57686321
93TAOK30.57521807
94PRKCZ0.57302022
95RIPK40.57278662
96TNK20.54443680
97ERBB20.54240477
98CAMK40.54171132
99ADRBK10.52764078
100PRKAA10.52624867
101TLK10.51366523
102PRKACA0.50376635
103SGK10.50167722
104RPS6KA30.49098023
105GRK70.49036818
106MAP2K60.48197184
107MAP2K10.47861551
108MAP3K70.47237665
109MAPK100.46713852
110MAP3K60.46696298
111CAMK10.44940043
112GRK10.43731543
113DAPK10.43697488
114PTK2B0.43498352
115BRSK10.42693340
116PRKCA0.42373553
117TRIM280.42198333
118DDR20.41527983
119ARAF0.41508847
120CAMK1D0.41235722
121PRKCH0.40769501
122FES0.40114840
123WNK10.39860361
124BMPR1B0.39800532
125NEK60.36582078
126CSNK1A10.36044564
127BCKDK0.34933163
128PRKCI0.31893494
129STK160.31438155
130PDK10.31109934
131CSNK1D0.30807735

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.88322683
2Synaptic vesicle cycle_Homo sapiens_hsa047212.56079743
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.30310250
4Cardiac muscle contraction_Homo sapiens_hsa042602.26694944
5GABAergic synapse_Homo sapiens_hsa047272.25447667
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.21882212
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.13518742
8Glutamatergic synapse_Homo sapiens_hsa047241.94153290
9Circadian entrainment_Homo sapiens_hsa047131.93061186
10Morphine addiction_Homo sapiens_hsa050321.89219508
11Oxidative phosphorylation_Homo sapiens_hsa001901.80615004
12Olfactory transduction_Homo sapiens_hsa047401.78410472
13Butanoate metabolism_Homo sapiens_hsa006501.71519353
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.69829220
15Vitamin B6 metabolism_Homo sapiens_hsa007501.68601855
16Dopaminergic synapse_Homo sapiens_hsa047281.67363732
17Parkinsons disease_Homo sapiens_hsa050121.66632997
18Axon guidance_Homo sapiens_hsa043601.66078179
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64089438
20* Insulin secretion_Homo sapiens_hsa049111.62119393
21Alzheimers disease_Homo sapiens_hsa050101.54886856
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.52915052
23Cholinergic synapse_Homo sapiens_hsa047251.49396871
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48441009
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.47554609
26Serotonergic synapse_Homo sapiens_hsa047261.40559330
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39909929
28Long-term potentiation_Homo sapiens_hsa047201.39539078
29Taste transduction_Homo sapiens_hsa047421.35930747
30Propanoate metabolism_Homo sapiens_hsa006401.34178722
31Salivary secretion_Homo sapiens_hsa049701.32501437
32Amphetamine addiction_Homo sapiens_hsa050311.31781863
33Arginine biosynthesis_Homo sapiens_hsa002201.25663395
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25324343
35Calcium signaling pathway_Homo sapiens_hsa040201.22654775
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.17977008
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16192443
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.15823399
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15775160
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14994553
41Gastric acid secretion_Homo sapiens_hsa049711.14968679
42Phototransduction_Homo sapiens_hsa047441.12979383
43Oxytocin signaling pathway_Homo sapiens_hsa049211.12327794
44Nitrogen metabolism_Homo sapiens_hsa009101.10490573
45Long-term depression_Homo sapiens_hsa047301.08099084
46Cocaine addiction_Homo sapiens_hsa050301.03926230
47Renin secretion_Homo sapiens_hsa049241.03813849
48Dilated cardiomyopathy_Homo sapiens_hsa054141.02649342
49Pyruvate metabolism_Homo sapiens_hsa006201.00791704
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00301509
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99473970
52Huntingtons disease_Homo sapiens_hsa050160.98409103
53Fatty acid elongation_Homo sapiens_hsa000620.98212523
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.96026284
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94675643
56Melanogenesis_Homo sapiens_hsa049160.92591428
57Fatty acid metabolism_Homo sapiens_hsa012120.92498860
58Gap junction_Homo sapiens_hsa045400.91788663
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90819729
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90178725
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88630808
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88459848
63Fatty acid degradation_Homo sapiens_hsa000710.87836618
64Type II diabetes mellitus_Homo sapiens_hsa049300.84897459
65Collecting duct acid secretion_Homo sapiens_hsa049660.84310982
66GnRH signaling pathway_Homo sapiens_hsa049120.84115107
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79729505
68Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77147510
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75911705
70Bile secretion_Homo sapiens_hsa049760.75774592
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75644035
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74547705
73Steroid biosynthesis_Homo sapiens_hsa001000.73406155
74ErbB signaling pathway_Homo sapiens_hsa040120.71449279
75Tryptophan metabolism_Homo sapiens_hsa003800.70929959
76Oocyte meiosis_Homo sapiens_hsa041140.70191892
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.68760018
78Thyroid hormone synthesis_Homo sapiens_hsa049180.67568454
79Glucagon signaling pathway_Homo sapiens_hsa049220.67346583
80cAMP signaling pathway_Homo sapiens_hsa040240.67058071
81Carbon metabolism_Homo sapiens_hsa012000.64826911
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58173318
83Insulin signaling pathway_Homo sapiens_hsa049100.56433338
84Ether lipid metabolism_Homo sapiens_hsa005650.55725394
85Wnt signaling pathway_Homo sapiens_hsa043100.55480554
86Rap1 signaling pathway_Homo sapiens_hsa040150.54828424
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54636955
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54324961
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53556807
90Pancreatic secretion_Homo sapiens_hsa049720.53448203
91Linoleic acid metabolism_Homo sapiens_hsa005910.51766050
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51644679
93Estrogen signaling pathway_Homo sapiens_hsa049150.51549599
94Regulation of autophagy_Homo sapiens_hsa041400.48990680
95Circadian rhythm_Homo sapiens_hsa047100.47659258
96Glioma_Homo sapiens_hsa052140.46914543
97PPAR signaling pathway_Homo sapiens_hsa033200.46782839
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45980479
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44748165
100Ras signaling pathway_Homo sapiens_hsa040140.44642255
101MAPK signaling pathway_Homo sapiens_hsa040100.44627311
102beta-Alanine metabolism_Homo sapiens_hsa004100.44313953
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.43952588
104Ovarian steroidogenesis_Homo sapiens_hsa049130.43191101
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42703230
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40352364
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38642469
108Basal cell carcinoma_Homo sapiens_hsa052170.38429251
109Phenylalanine metabolism_Homo sapiens_hsa003600.37909162
110Alcoholism_Homo sapiens_hsa050340.36632324
111Endometrial cancer_Homo sapiens_hsa052130.36528265
112Sulfur relay system_Homo sapiens_hsa041220.35435812
113Mineral absorption_Homo sapiens_hsa049780.35105995
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34631533
115Inositol phosphate metabolism_Homo sapiens_hsa005620.34544277
116Hippo signaling pathway_Homo sapiens_hsa043900.34055379
117Arginine and proline metabolism_Homo sapiens_hsa003300.33975201
118Vibrio cholerae infection_Homo sapiens_hsa051100.33928213
119Tyrosine metabolism_Homo sapiens_hsa003500.33742349
120VEGF signaling pathway_Homo sapiens_hsa043700.33657121
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33121404
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.32236736
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.30396771
124Dorso-ventral axis formation_Homo sapiens_hsa043200.25019399
125Hedgehog signaling pathway_Homo sapiens_hsa043400.23575828
126Choline metabolism in cancer_Homo sapiens_hsa052310.20373678
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18145744

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »