KCNN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ionotropic glutamate receptor signaling pathway (GO:0035235)4.62396269
2gamma-aminobutyric acid transport (GO:0015812)4.55014715
3vocalization behavior (GO:0071625)4.40840917
4glutamate receptor signaling pathway (GO:0007215)4.37248978
5regulation of DNA methylation (GO:0044030)4.27350314
6cellular potassium ion homeostasis (GO:0030007)4.10156686
7regulation of short-term neuronal synaptic plasticity (GO:0048172)4.08664501
8neuron cell-cell adhesion (GO:0007158)4.08655666
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.03115705
10neurotransmitter-gated ion channel clustering (GO:0072578)4.02387881
11negative regulation of synaptic transmission, GABAergic (GO:0032229)3.99693604
12protein localization to synapse (GO:0035418)3.95614036
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.82486763
14L-serine metabolic process (GO:0006563)3.76528717
15synaptic transmission, glutamatergic (GO:0035249)3.68810195
16membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.60833826
17paraxial mesoderm development (GO:0048339)3.60739006
18pre-miRNA processing (GO:0031054)3.60412718
19regulation of glutamate receptor signaling pathway (GO:1900449)3.60231269
20synaptic vesicle exocytosis (GO:0016079)3.60207336
21G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.58915326
22glutamate secretion (GO:0014047)3.57400258
23piRNA metabolic process (GO:0034587)3.53471063
24cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.50978966
25gamma-aminobutyric acid signaling pathway (GO:0007214)3.48524569
26sodium ion export (GO:0071436)3.46851199
27regulation of posttranscriptional gene silencing (GO:0060147)3.46319473
28regulation of gene silencing by miRNA (GO:0060964)3.46319473
29regulation of gene silencing by RNA (GO:0060966)3.46319473
30regulation of long-term neuronal synaptic plasticity (GO:0048169)3.46235588
31cell communication by electrical coupling (GO:0010644)3.45278261
32neuron-neuron synaptic transmission (GO:0007270)3.43385911
33neuron recognition (GO:0008038)3.36479847
34neuronal action potential propagation (GO:0019227)3.35158446
35positive regulation of synapse maturation (GO:0090129)3.35036362
36retinal cone cell development (GO:0046549)3.33417587
37serine family amino acid biosynthetic process (GO:0009070)3.30778408
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.28046328
39neurotransmitter secretion (GO:0007269)3.27541223
40C4-dicarboxylate transport (GO:0015740)3.27517926
41locomotory exploration behavior (GO:0035641)3.25712380
42cellular sodium ion homeostasis (GO:0006883)3.25378769
43regulation of neuronal synaptic plasticity (GO:0048168)3.23472957
44biotin metabolic process (GO:0006768)3.22929822
45positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.22180528
46low-density lipoprotein particle remodeling (GO:0034374)3.18850002
47glutamate metabolic process (GO:0006536)3.15901886
48regulation of histone H3-K9 methylation (GO:0051570)3.14911730
49triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.13551340
50artery development (GO:0060840)3.13352692
51regulation of synaptic transmission, glutamatergic (GO:0051966)3.12449771
52anterior/posterior axis specification, embryo (GO:0008595)3.11616256
53positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.11452393
54long-term memory (GO:0007616)3.06890196
55dicarboxylic acid biosynthetic process (GO:0043650)3.06858809
56DNA methylation involved in gamete generation (GO:0043046)3.06097887
57regulation of meiosis I (GO:0060631)3.04210190
58positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.01111574
59L-phenylalanine catabolic process (GO:0006559)2.99010513
60erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.99010513
61long-term synaptic potentiation (GO:0060291)2.96797573
62transmission of nerve impulse (GO:0019226)2.96438314
63L-amino acid import (GO:0043092)2.94815331
64regulation of excitatory postsynaptic membrane potential (GO:0060079)2.94307822
65negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.94057701
66reverse cholesterol transport (GO:0043691)2.93389335
67behavioral response to cocaine (GO:0048148)2.92412138
68behavioral defense response (GO:0002209)2.92045214
69behavioral fear response (GO:0001662)2.92045214
70synaptic vesicle endocytosis (GO:0048488)2.91404795
71neurotransmitter transport (GO:0006836)2.91390828
72regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.91189093
73axonal fasciculation (GO:0007413)2.90952072
74inner ear receptor cell development (GO:0060119)2.90659698
75glyoxylate metabolic process (GO:0046487)2.89281264
76negative regulation of astrocyte differentiation (GO:0048712)2.88915123
77layer formation in cerebral cortex (GO:0021819)2.88319793
78dicarboxylic acid catabolic process (GO:0043649)2.88318960
79multicellular organism reproduction (GO:0032504)2.87828734
80fear response (GO:0042596)2.86505475
81presynaptic membrane assembly (GO:0097105)2.86014236
82regulation of postsynaptic membrane potential (GO:0060078)2.85813358
83response to auditory stimulus (GO:0010996)2.85806615
84exploration behavior (GO:0035640)2.83084073
85response to histamine (GO:0034776)2.82672252
86meiotic cell cycle (GO:0051321)2.82557198
87high-density lipoprotein particle remodeling (GO:0034375)2.81905297
88regulation of synaptic plasticity (GO:0048167)2.81130497
89regulation of neurotransmitter levels (GO:0001505)2.80908096
90DNA replication-dependent nucleosome assembly (GO:0006335)2.79690684
91DNA replication-dependent nucleosome organization (GO:0034723)2.79690684
92regulation of female gonad development (GO:2000194)2.79546404
93cellular ketone body metabolic process (GO:0046950)2.79176413
94negative regulation of cytosolic calcium ion concentration (GO:0051481)2.79058402
95protein-lipid complex remodeling (GO:0034368)2.76415673
96macromolecular complex remodeling (GO:0034367)2.76415673
97plasma lipoprotein particle remodeling (GO:0034369)2.76415673
98regulation of cholesterol esterification (GO:0010872)2.75840491
99regulation of synapse maturation (GO:0090128)2.75434689
100regulation of mitotic spindle checkpoint (GO:1903504)2.74572217
101regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.74572217
102regulation of cell fate specification (GO:0042659)2.74103626
103synapsis (GO:0007129)2.73891685
104dendritic spine morphogenesis (GO:0060997)2.71865316
105erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.71687802
106L-phenylalanine metabolic process (GO:0006558)2.71687802
107regulation of synaptic vesicle exocytosis (GO:2000300)2.71408656
108cerebellar granule cell differentiation (GO:0021707)2.71384005
109aromatic amino acid family catabolic process (GO:0009074)2.71264040
110regulation of synaptic vesicle transport (GO:1902803)2.70753963
111regulation of female receptivity (GO:0045924)2.70401196
112presynaptic membrane organization (GO:0097090)2.69076468
113female mating behavior (GO:0060180)2.68238579
114CENP-A containing nucleosome assembly (GO:0034080)2.67547839
115negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.66719023
116bile acid biosynthetic process (GO:0006699)2.66312905
117chromatin remodeling at centromere (GO:0031055)2.66278409
118innervation (GO:0060384)2.65757728
119amino acid import (GO:0043090)2.65647434
120positive regulation of dendritic spine development (GO:0060999)2.65422456
121neurotransmitter uptake (GO:0001504)2.65187425
122regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.65018582
123alpha-linolenic acid metabolic process (GO:0036109)2.64666979
124endothelial cell morphogenesis (GO:0001886)2.63423488
125startle response (GO:0001964)2.63054322
126proline transport (GO:0015824)2.62135139
127negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.61838619
128alanine transport (GO:0032328)2.58699609
129learning (GO:0007612)2.58420885
130aspartate family amino acid catabolic process (GO:0009068)2.58398003
131potassium ion homeostasis (GO:0055075)2.58235153
132lysine metabolic process (GO:0006553)2.57823025
133lysine catabolic process (GO:0006554)2.57823025
134regulation of dendritic spine morphogenesis (GO:0061001)2.56704016
135postsynaptic membrane organization (GO:0001941)2.55419305
136DNA replication checkpoint (GO:0000076)2.54353736
137negative regulation of histone methylation (GO:0031061)2.49462491
138negative regulation of translation, ncRNA-mediated (GO:0040033)2.49439527
139regulation of translation, ncRNA-mediated (GO:0045974)2.49439527
140negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.49439527
141histone exchange (GO:0043486)2.48369432
142gene silencing by RNA (GO:0031047)2.46330839
143branching involved in prostate gland morphogenesis (GO:0060442)2.45389509
144female gamete generation (GO:0007292)2.45334036
145branched-chain amino acid catabolic process (GO:0009083)2.44157136
146prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.43710213
147cardiac chamber formation (GO:0003207)2.42143120
148telomere maintenance via telomerase (GO:0007004)2.40486482
149homocysteine metabolic process (GO:0050667)2.40056197
150positive regulation of cardiac muscle tissue growth (GO:0055023)2.39673000
151cardiac muscle cell development (GO:0055013)2.37327136
152DNA double-strand break processing (GO:0000729)2.34161309
153positive regulation of cardiac muscle cell proliferation (GO:0060045)2.32714296
154positive regulation of histone H3-K4 methylation (GO:0051571)2.32255113
155regulation of gene silencing (GO:0060968)2.31530376
156positive regulation of male gonad development (GO:2000020)2.31313479
157regulation of helicase activity (GO:0051095)2.30268248
158cochlea development (GO:0090102)2.28749126
159cardiac muscle hypertrophy (GO:0003300)2.28166328
160positive regulation of uterine smooth muscle contraction (GO:0070474)2.27971422
161cardiac muscle hypertrophy in response to stress (GO:0014898)2.27398915
162muscle hypertrophy in response to stress (GO:0003299)2.27398915
163cardiac muscle adaptation (GO:0014887)2.27398915
164relaxation of smooth muscle (GO:0044557)2.25563983
165protein localization to kinetochore (GO:0034501)2.23990425
166regulation of steroid hormone secretion (GO:2000831)2.23788718
167dorsal/ventral axis specification (GO:0009950)2.23003068
168lymphangiogenesis (GO:0001946)2.22141241
169regulation of spindle checkpoint (GO:0090231)2.19086692
170ventricular septum morphogenesis (GO:0060412)2.17924543
171binding of sperm to zona pellucida (GO:0007339)2.16382902
172outer ear morphogenesis (GO:0042473)2.16239372
173mitochondrial RNA metabolic process (GO:0000959)2.12909400
174cerebellar Purkinje cell layer development (GO:0021680)2.12897558
175negative regulation of DNA-dependent DNA replication (GO:2000104)2.12622729
176striated muscle hypertrophy (GO:0014897)2.12226335
177DNA damage response, detection of DNA damage (GO:0042769)2.12125898
178cardiac cell development (GO:0055006)2.11113241
179mitotic metaphase plate congression (GO:0007080)2.10949852
180atrial septum morphogenesis (GO:0060413)2.09740824
181regulation of acrosome reaction (GO:0060046)2.07329157
182glycine metabolic process (GO:0006544)2.07140161
183regulation of chromatin silencing (GO:0031935)2.07124213
184negative regulation of reproductive process (GO:2000242)2.06991127
185negative regulation of transcription regulatory region DNA binding (GO:2000678)2.06545326
186regulation of nuclear cell cycle DNA replication (GO:0033262)2.05357365
187cardiac ventricle formation (GO:0003211)2.04029569
188positive regulation of cardiac muscle tissue development (GO:0055025)2.03007419
189DNA replication-independent nucleosome organization (GO:0034724)2.02751304
190DNA replication-independent nucleosome assembly (GO:0006336)2.02751304

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.52842495
2GBX2_23144817_ChIP-Seq_PC3_Human3.80542942
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.57000141
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.82881055
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.82275022
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.74788298
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.62609075
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51188161
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.43860395
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.33735041
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.33735041
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.30817722
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.29953640
14* EED_16625203_ChIP-ChIP_MESCs_Mouse2.29850695
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29132110
16* REST_21632747_ChIP-Seq_MESCs_Mouse2.25927975
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.19523832
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.14851751
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.12782197
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.11065612
21* AR_21909140_ChIP-Seq_LNCAP_Human2.04048038
22TAF15_26573619_Chip-Seq_HEK293_Human1.95391455
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92984184
24AR_21572438_ChIP-Seq_LNCaP_Human1.92003560
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91689097
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.90588855
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88290257
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.86290223
29HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.86252301
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86119829
31DROSHA_22980978_ChIP-Seq_HELA_Human1.84541305
32KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.80053815
33KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.80053815
34KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.80053815
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.74480448
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.71879324
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71658704
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71506949
39EWS_26573619_Chip-Seq_HEK293_Human1.69460807
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69342035
41SMAD4_21799915_ChIP-Seq_A2780_Human1.69082624
42* P300_19829295_ChIP-Seq_ESCs_Human1.69070957
43RARB_27405468_Chip-Seq_BRAIN_Mouse1.67408317
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64603138
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62671863
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57363734
47* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56130989
48* CBX2_27304074_Chip-Seq_ESCs_Mouse1.55856663
49* PIAS1_25552417_ChIP-Seq_VCAP_Human1.55536019
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54754419
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53955065
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50959295
53E2F7_22180533_ChIP-Seq_HELA_Human1.50160347
54IRF1_19129219_ChIP-ChIP_H3396_Human1.48136042
55* IKZF1_21737484_ChIP-ChIP_HCT116_Human1.44051436
56* AR_25329375_ChIP-Seq_VCAP_Human1.43869136
57* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43773847
58* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43591443
59RXR_22158963_ChIP-Seq_LIVER_Mouse1.41122057
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39728708
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39369149
62* SOX2_16153702_ChIP-ChIP_HESCs_Human1.37881024
63* SMAD3_21741376_ChIP-Seq_EPCs_Human1.37428259
64BCAT_22108803_ChIP-Seq_LS180_Human1.37105636
65FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.36868440
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36764101
67FUS_26573619_Chip-Seq_HEK293_Human1.35040178
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.34082098
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.33716145
70* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31825766
71* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30908925
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30546937
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.27251500
74ZNF274_21170338_ChIP-Seq_K562_Hela1.25701847
75GATA1_26923725_Chip-Seq_HPCs_Mouse1.25441216
76LXR_22158963_ChIP-Seq_LIVER_Mouse1.25201726
77* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24888255
78IGF1R_20145208_ChIP-Seq_DFB_Human1.23455093
79* STAT3_23295773_ChIP-Seq_U87_Human1.23179664
80* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22300220
81SOX2_21211035_ChIP-Seq_LN229_Gbm1.22218538
82MYC_18555785_ChIP-Seq_MESCs_Mouse1.21642044
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20930390
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20878274
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20664305
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20405194
87* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20401348
88VDR_22108803_ChIP-Seq_LS180_Human1.20343341
89YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20151872
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19222197
91* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18156874
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17584885
93TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.17288411
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17162090
95E2F4_17652178_ChIP-ChIP_JURKAT_Human1.16675096
96RING1B_27294783_Chip-Seq_ESCs_Mouse1.15379657
97TP53_18474530_ChIP-ChIP_U2OS_Human1.13528875
98AR_19668381_ChIP-Seq_PC3_Human1.13494023
99SALL1_21062744_ChIP-ChIP_HESCs_Human1.12809924
100SOX9_26525672_Chip-Seq_HEART_Mouse1.12333129
101STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10854024
102RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10674983
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10096294
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10096294
105* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10047029
106TP53_16413492_ChIP-PET_HCT116_Human1.09560904
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08615410
108NANOG_18555785_Chip-Seq_ESCs_Mouse1.08131818
109FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.07791145
110* RUNX2_22187159_ChIP-Seq_PCA_Human1.06061882
111HTT_18923047_ChIP-ChIP_STHdh_Human1.05769484
112ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05744387
113MYC_18940864_ChIP-ChIP_HL60_Human1.04849199
114ARNT_22903824_ChIP-Seq_MCF-7_Human1.04611506
115TCF4_23295773_ChIP-Seq_U87_Human1.04509087
116EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04311951
117LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04114081
118* NANOG_16153702_ChIP-ChIP_HESCs_Human1.03605775
119IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02898756
120CBP_20019798_ChIP-Seq_JUKART_Human1.02898756
121TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02610472
122CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01388871
123TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01098540
124NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00528554
125MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99352874
126EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98753598
127SMAD_19615063_ChIP-ChIP_OVARY_Human0.98393569
128EP300_21415370_ChIP-Seq_HL-1_Mouse0.97138550
129ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97051020
130SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96507432
131* PRDM14_20953172_ChIP-Seq_ESCs_Human0.96455648
132* SMAD3_21741376_ChIP-Seq_ESCs_Human0.96432986
133* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95770948
134CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95595723
135E2F1_18555785_Chip-Seq_ESCs_Mouse0.95434693
136* SMAD4_21741376_ChIP-Seq_HESCs_Human0.95214021
137ER_23166858_ChIP-Seq_MCF-7_Human0.95148409
138* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.94368935
139JUN_21703547_ChIP-Seq_K562_Human0.94199356
140RNF2_27304074_Chip-Seq_NSC_Mouse0.93945858
141ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93447519
142* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93219412
143YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92993636
144PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92964975
145FLI1_27457419_Chip-Seq_LIVER_Mouse0.92953596
146P53_22387025_ChIP-Seq_ESCs_Mouse0.92846417
147JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.91856339
148THAP11_20581084_ChIP-Seq_MESCs_Mouse0.91304250
149* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.88819151
150CREB1_15753290_ChIP-ChIP_HEK293T_Human0.87735351
151PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86902028
152GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86407248
153NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.86374533
154POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85664982

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.72096879
2MP0003880_abnormal_central_pattern4.11291539
3* MP0003635_abnormal_synaptic_transmissio3.37184852
4MP0002139_abnormal_hepatobiliary_system3.10117506
5MP0008877_abnormal_DNA_methylation3.06918726
6MP0009745_abnormal_behavioral_response2.95533072
7* MP0002063_abnormal_learning/memory/cond2.85135979
8MP0005360_urolithiasis2.82215005
9MP0003718_maternal_effect2.78526619
10MP0004270_analgesia2.78099013
11MP0003941_abnormal_skin_development2.76136819
12MP0002064_seizures2.65556690
13MP0002572_abnormal_emotion/affect_behav2.58153171
14MP0003329_amyloid_beta_deposits2.51700642
15MP0001501_abnormal_sleep_pattern2.39891821
16MP0001968_abnormal_touch/_nociception2.34355665
17MP0001486_abnormal_startle_reflex2.32729270
18MP0009046_muscle_twitch2.30856116
19MP0005085_abnormal_gallbladder_physiolo2.22471718
20MP0001440_abnormal_grooming_behavior2.21985436
21MP0002736_abnormal_nociception_after2.21610199
22* MP0002272_abnormal_nervous_system2.18597901
23MP0005423_abnormal_somatic_nervous2.17999317
24MP0001984_abnormal_olfaction2.17650504
25MP0005365_abnormal_bile_salt2.13981597
26MP0005646_abnormal_pituitary_gland2.00814568
27MP0004858_abnormal_nervous_system1.93973914
28MP0002735_abnormal_chemical_nociception1.92497068
29MP0002822_catalepsy1.90902333
30MP0008875_abnormal_xenobiotic_pharmacok1.89950013
31MP0003890_abnormal_embryonic-extraembry1.87073812
32MP0002734_abnormal_mechanical_nocicepti1.85277182
33MP0002102_abnormal_ear_morphology1.82948461
34MP0003693_abnormal_embryo_hatching1.80431660
35MP0002067_abnormal_sensory_capabilities1.79022988
36MP0002837_dystrophic_cardiac_calcinosis1.77323286
37MP0006276_abnormal_autonomic_nervous1.76379733
38MP0003136_yellow_coat_color1.71252422
39MP0000537_abnormal_urethra_morphology1.66886500
40MP0000778_abnormal_nervous_system1.64055052
41MP0002160_abnormal_reproductive_system1.62262658
42MP0001502_abnormal_circadian_rhythm1.61100546
43MP0002733_abnormal_thermal_nociception1.57913067
44MP0004885_abnormal_endolymph1.57593365
45MP0006292_abnormal_olfactory_placode1.56103352
46* MP0002557_abnormal_social/conspecific_i1.55169901
47MP0002184_abnormal_innervation1.54201098
48MP0008789_abnormal_olfactory_epithelium1.53394949
49MP0006072_abnormal_retinal_apoptosis1.52293880
50MP0008057_abnormal_DNA_replication1.50439584
51MP0004233_abnormal_muscle_weight1.49804691
52MP0010329_abnormal_lipoprotein_level1.49438035
53MP0008932_abnormal_embryonic_tissue1.48013929
54MP0004036_abnormal_muscle_relaxation1.46799798
55MP0003937_abnormal_limbs/digits/tail_de1.46455610
56MP0000604_amyloidosis1.45763344
57MP0005647_abnormal_sex_gland1.41813267
58MP0005386_behavior/neurological_phenoty1.38107880
59MP0004924_abnormal_behavior1.38107880
60MP0004084_abnormal_cardiac_muscle1.38088507
61MP0003567_abnormal_fetal_cardiomyocyte1.37248444
62MP0009780_abnormal_chondrocyte_physiolo1.37077652
63MP0002909_abnormal_adrenal_gland1.36572934
64MP0005332_abnormal_amino_acid1.36440892
65MP0003119_abnormal_digestive_system1.35187487
66MP0001970_abnormal_pain_threshold1.34906512
67MP0005551_abnormal_eye_electrophysiolog1.34731535
68MP0008058_abnormal_DNA_repair1.30748676
69MP0003121_genomic_imprinting1.25088476
70MP0001529_abnormal_vocalization1.23577247
71MP0003690_abnormal_glial_cell1.22858564
72MP0008569_lethality_at_weaning1.21553805
73MP0001730_embryonic_growth_arrest1.21364877
74MP0003111_abnormal_nucleus_morphology1.21221773
75MP0010094_abnormal_chromosome_stability1.19391198
76MP0000631_abnormal_neuroendocrine_gland1.16871877
77MP0004142_abnormal_muscle_tone1.16830691
78MP0003633_abnormal_nervous_system1.16102706
79MP0002638_abnormal_pupillary_reflex1.14837156
80MP0004133_heterotaxia1.14715358
81MP0004215_abnormal_myocardial_fiber1.14427365
82* MP0002066_abnormal_motor_capabilities/c1.14188356
83MP0000049_abnormal_middle_ear1.12182178
84MP0005253_abnormal_eye_physiology1.10964740
85MP0002882_abnormal_neuron_morphology1.10260062
86MP0000955_abnormal_spinal_cord1.10170684
87MP0005535_abnormal_body_temperature1.08984635
88MP0002210_abnormal_sex_determination1.08803975
89MP0001929_abnormal_gametogenesis1.08762291
90MP0003631_nervous_system_phenotype1.06661600
91MP0004957_abnormal_blastocyst_morpholog1.04716110
92MP0003077_abnormal_cell_cycle1.03168425
93MP0001905_abnormal_dopamine_level1.02854562
94MP0009672_abnormal_birth_weight1.02541879
95MP0002254_reproductive_system_inflammat1.02204829
96MP0001188_hyperpigmentation1.01933861
97MP0002876_abnormal_thyroid_physiology1.01091898
98MP0005187_abnormal_penis_morphology1.00865807
99MP0005410_abnormal_fertilization1.00721410
100MP0005645_abnormal_hypothalamus_physiol0.98548094
101MP0002108_abnormal_muscle_morphology0.97581331
102MP0003252_abnormal_bile_duct0.97261211
103MP0008872_abnormal_physiological_respon0.97073830
104MP0000653_abnormal_sex_gland0.97069407
105MP0005503_abnormal_tendon_morphology0.96967798
106MP0002234_abnormal_pharynx_morphology0.96765039
107MP0003879_abnormal_hair_cell0.96407336
108MP0004811_abnormal_neuron_physiology0.95514437
109MP0003698_abnormal_male_reproductive0.94533657
110MP0002084_abnormal_developmental_patter0.94502157
111MP0001145_abnormal_male_reproductive0.93885335
112MP0002938_white_spotting0.93079418
113MP0003632_abnormal_nervous_system0.92799939
114MP0002069_abnormal_eating/drinking_beha0.92726625
115MP0002152_abnormal_brain_morphology0.92318539
116MP0008874_decreased_physiological_sensi0.88847216
117MP0002090_abnormal_vision0.88728804
118MP0010386_abnormal_urinary_bladder0.88034292
119MP0002229_neurodegeneration0.87565583
120MP0005595_abnormal_vascular_smooth0.87410052
121MP0001299_abnormal_eye_distance/0.85848614
122MP0001293_anophthalmia0.85193305
123MP0001963_abnormal_hearing_physiology0.84052842
124MP0001485_abnormal_pinna_reflex0.83575634
125MP0002118_abnormal_lipid_homeostasis0.83551339
126MP0009250_abnormal_appendicular_skeleto0.83485866
127MP0003699_abnormal_female_reproductive0.82690996
128MP0004085_abnormal_heartbeat0.81989021
129MP0002161_abnormal_fertility/fecundity0.80934905
130MP0003137_abnormal_impulse_conducting0.79567960
131MP0005380_embryogenesis_phenotype0.79566175
132MP0001672_abnormal_embryogenesis/_devel0.79566175
133MP0005620_abnormal_muscle_contractility0.77758131
134MP0003787_abnormal_imprinting0.77523050
135MP0000762_abnormal_tongue_morphology0.76687886
136MP0003861_abnormal_nervous_system0.76516643
137MP0000026_abnormal_inner_ear0.75911505
138MP0004145_abnormal_muscle_electrophysio0.75900287
139MP0005395_other_phenotype0.75816053
140MP0003634_abnormal_glial_cell0.75137623
141MP0003868_abnormal_feces_composition0.74535394
142MP0002752_abnormal_somatic_nervous0.73719390
143MP0001177_atelectasis0.73495397
144MP0003195_calcinosis0.72003674
145MP0005499_abnormal_olfactory_system0.71012622
146MP0005394_taste/olfaction_phenotype0.71012622
147MP0009840_abnormal_foam_cell0.70680265
148MP0003646_muscle_fatigue0.69264643
149MP0009384_cardiac_valve_regurgitation0.66551702
150MP0003806_abnormal_nucleotide_metabolis0.65737564
151MP0004484_altered_response_of0.64461920
152MP0005167_abnormal_blood-brain_barrier0.64399512
153MP0004742_abnormal_vestibular_system0.64296613
154MP0003075_altered_response_to0.63820944
155MP0000751_myopathy0.63351939

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.86759019
2Hyperventilation (HP:0002883)5.36510883
3Epileptic encephalopathy (HP:0200134)4.54083875
4Focal seizures (HP:0007359)4.30690843
5Neurofibrillary tangles (HP:0002185)3.93358979
6Cerebral inclusion bodies (HP:0100314)3.93344631
7Febrile seizures (HP:0002373)3.89684607
8Atonic seizures (HP:0010819)3.86509789
9Generalized tonic-clonic seizures (HP:0002069)3.78690700
10Absence seizures (HP:0002121)3.74360412
11Status epilepticus (HP:0002133)3.64931090
12Myokymia (HP:0002411)3.61216796
13Visual hallucinations (HP:0002367)3.60322839
14Abnormality of the labia minora (HP:0012880)3.56544643
15Dialeptic seizures (HP:0011146)3.49127472
16Prolonged partial thromboplastin time (HP:0003645)3.45178717
17Hemiparesis (HP:0001269)3.42719331
18Diplopia (HP:0000651)3.26782180
19Abnormality of binocular vision (HP:0011514)3.26782180
20Gonadotropin excess (HP:0000837)3.21726894
21Deep venous thrombosis (HP:0002625)3.09420904
22Confusion (HP:0001289)3.06534382
23Hyperlipoproteinemia (HP:0010980)3.00290758
24Hyperglycinemia (HP:0002154)2.95071166
25Progressive cerebellar ataxia (HP:0002073)2.93015665
26Dysdiadochokinesis (HP:0002075)2.92946080
27Excessive salivation (HP:0003781)2.89097134
28Drooling (HP:0002307)2.89097134
29Septo-optic dysplasia (HP:0100842)2.88607968
30Intrahepatic cholestasis (HP:0001406)2.85042837
31Supranuclear gaze palsy (HP:0000605)2.83823831
32Hemiplegia (HP:0002301)2.82467520
33Abnormality of aromatic amino acid family metabolism (HP:0004338)2.79291363
34Epileptiform EEG discharges (HP:0011182)2.74547080
35Homocystinuria (HP:0002156)2.72457128
36Abnormality of homocysteine metabolism (HP:0010919)2.72457128
37Aplasia of the musculature (HP:0100854)2.72384391
38Choanal stenosis (HP:0000452)2.71922838
39Ketosis (HP:0001946)2.60991457
40Xanthomatosis (HP:0000991)2.58685399
41Aplasia/Hypoplasia of the fovea (HP:0008060)2.56363005
42Hypoplasia of the fovea (HP:0007750)2.56363005
43Broad-based gait (HP:0002136)2.55853033
44Sparse lateral eyebrow (HP:0005338)2.55616428
45Megalencephaly (HP:0001355)2.55300539
46EEG with generalized epileptiform discharges (HP:0011198)2.54867179
47Impaired social interactions (HP:0000735)2.47819315
48Abnormal social behavior (HP:0012433)2.47819315
49Oligodactyly (hands) (HP:0001180)2.46474134
50Hypobetalipoproteinemia (HP:0003563)2.46306384
51Poor eye contact (HP:0000817)2.41589622
52Hyperglycinuria (HP:0003108)2.40752416
53Aplasia of the phalanges of the hand (HP:0009802)2.36681769
54Aplasia involving bones of the extremities (HP:0009825)2.36681769
55Aplasia involving bones of the upper limbs (HP:0009823)2.36681769
56Abnormality of glycine metabolism (HP:0010895)2.35982634
57Abnormality of serine family amino acid metabolism (HP:0010894)2.35982634
58Ketoacidosis (HP:0001993)2.35773206
59Hypoalphalipoproteinemia (HP:0003233)2.35483940
60Hypsarrhythmia (HP:0002521)2.34729542
61Dysmetria (HP:0001310)2.33883695
62Postural instability (HP:0002172)2.33868244
63Anxiety (HP:0000739)2.32089990
64Absent speech (HP:0001344)2.30312733
65Generalized myoclonic seizures (HP:0002123)2.28509958
66Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.28168718
67Action tremor (HP:0002345)2.27565324
68Optic nerve hypoplasia (HP:0000609)2.26166468
69Aplasia/Hypoplasia of the sternum (HP:0006714)2.24977414
70Supernumerary spleens (HP:0009799)2.24524282
71Abnormality of the fovea (HP:0000493)2.24464360
72Fair hair (HP:0002286)2.23761522
73Absent radius (HP:0003974)2.23457405
74Hypolipoproteinemia (HP:0010981)2.22098749
75Hyperammonemia (HP:0001987)2.19531539
76Amblyopia (HP:0000646)2.15108936
77Blue irides (HP:0000635)2.14732966
78Birth length less than 3rd percentile (HP:0003561)2.14447577
79Abnormality of secondary sexual hair (HP:0009888)2.13900008
80Abnormality of the axillary hair (HP:0100134)2.13900008
81Clumsiness (HP:0002312)2.11320688
82Truncal ataxia (HP:0002078)2.10513535
83Delusions (HP:0000746)2.09523383
84Calf muscle hypertrophy (HP:0008981)2.09407840
85Hepatoblastoma (HP:0002884)2.07965168
86Aplasia involving forearm bones (HP:0009822)2.07908852
87Absent forearm bone (HP:0003953)2.07908852
88Polyphagia (HP:0002591)2.04626695
89Abnormality of sulfur amino acid metabolism (HP:0004339)2.04421254
90Abnormal eating behavior (HP:0100738)2.03967105
91Coronal craniosynostosis (HP:0004440)2.02706433
92Methylmalonic acidemia (HP:0002912)2.00889275
93Partial duplication of thumb phalanx (HP:0009944)2.00459774
94Gaze-evoked nystagmus (HP:0000640)2.00208597
95Exercise-induced muscle cramps (HP:0003710)1.98320790
96Global brain atrophy (HP:0002283)1.97974662
97Epidermoid cyst (HP:0200040)1.96258560
98Muscle hypertrophy of the lower extremities (HP:0008968)1.96194234
99Synostosis involving the elbow (HP:0003938)1.96111116
100Humeroradial synostosis (HP:0003041)1.96111116
101Shallow orbits (HP:0000586)1.96035603
102Absent septum pellucidum (HP:0001331)1.95931153
103Thickened helices (HP:0000391)1.95683819
104Abnormality of methionine metabolism (HP:0010901)1.95005743
105Tetraplegia (HP:0002445)1.93950528
106Conjugated hyperbilirubinemia (HP:0002908)1.93878302
107Bundle branch block (HP:0011710)1.93196419
108Amyloidosis (HP:0011034)1.92747459
109Complement deficiency (HP:0004431)1.91168925
110Abnormality of the septum pellucidum (HP:0007375)1.90528329
111Maternal diabetes (HP:0009800)1.90508897
112Lip pit (HP:0100267)1.90357363
113Aplasia/Hypoplasia involving the musculature (HP:0001460)1.90180697
114Abnormality of monocarboxylic acid metabolism (HP:0010996)1.90036636
115Depression (HP:0000716)1.89597341
116Abnormality of salivation (HP:0100755)1.88580695
117Colon cancer (HP:0003003)1.86809642
118Absent hair (HP:0002298)1.86381675
119Joint hemorrhage (HP:0005261)1.85814694
120Athetosis (HP:0002305)1.85693774
121Nephroblastoma (Wilms tumor) (HP:0002667)1.85048039
122Abnormal lung lobation (HP:0002101)1.84266903
123Impulsivity (HP:0100710)1.84221389
124Azoospermia (HP:0000027)1.84022054
125Psychosis (HP:0000709)1.83486321
126Retinal dysplasia (HP:0007973)1.83183468
127Progressive inability to walk (HP:0002505)1.82859960
128Embryonal renal neoplasm (HP:0011794)1.82216854
129Anomalous pulmonary venous return (HP:0010772)1.81893620
130Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.81579014
131Aplasia/Hypoplasia of the tibia (HP:0005772)1.80978060
132Protruding tongue (HP:0010808)1.80393653
133Bradykinesia (HP:0002067)1.77823299
134Syncope (HP:0001279)1.77179804
135Meckel diverticulum (HP:0002245)1.77111594
136Abnormality of the ileum (HP:0001549)1.76197534
137Skin pits (HP:0100276)1.74354968
138Spontaneous abortion (HP:0005268)1.74197038
139Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.74092190
140Abnormality of serum amino acid levels (HP:0003112)1.73932669
141Multiple enchondromatosis (HP:0005701)1.73283104
142Absent/shortened dynein arms (HP:0200106)1.72528074
143Dynein arm defect of respiratory motile cilia (HP:0012255)1.72528074
144Abdominal situs inversus (HP:0003363)1.72426071
145Abnormality of abdominal situs (HP:0011620)1.72426071
146Abnormal ciliary motility (HP:0012262)1.72020424
147Impaired vibration sensation in the lower limbs (HP:0002166)1.71907694
148Inability to walk (HP:0002540)1.71518250
149Abnormality of aspartate family amino acid metabolism (HP:0010899)1.71353770
150Dysmetric saccades (HP:0000641)1.71189334
151Sensorimotor neuropathy (HP:0007141)1.70456537
152Abnormality of the pulmonary veins (HP:0011718)1.70441530
153Abnormality of the shoulder girdle musculature (HP:0001435)1.70420308
154Short tibia (HP:0005736)1.70290722
155Duplication of thumb phalanx (HP:0009942)1.70278447
156Partial duplication of the phalanx of hand (HP:0009999)1.70152343
157Abnormality of the aortic arch (HP:0012303)1.70008348
158Hypophosphatemic rickets (HP:0004912)1.66898499
159Hyperinsulinemic hypoglycemia (HP:0000825)1.65818971
160Neoplasm of the oral cavity (HP:0100649)1.65553511
161Breast aplasia (HP:0100783)1.64603457
162Hypoplastic left heart (HP:0004383)1.64019571
163Premature ovarian failure (HP:0008209)1.63447339
164Aplasia/Hypoplasia of the macula (HP:0008059)1.62895460
165Enlarged penis (HP:0000040)1.62585865
166Abnormality of the calf musculature (HP:0001430)1.60145754
167Cortical dysplasia (HP:0002539)1.60101228
168Bifid tongue (HP:0010297)1.60047433
169Glossoptosis (HP:0000162)1.59005726
170Depressed nasal tip (HP:0000437)1.56360959
171Hip contracture (HP:0003273)1.55681020
172Micropenis (HP:0000054)1.53869080
173Short 1st metacarpal (HP:0010034)1.53470057
174Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.53470057
175Chromosomal breakage induced by crosslinking agents (HP:0003221)1.52745410
176Preauricular pit (HP:0004467)1.52737195
177Periauricular skin pits (HP:0100277)1.52737195
178Proximal tubulopathy (HP:0000114)1.52585141
179Chromsome breakage (HP:0040012)1.52500962
180Hypoglycemic coma (HP:0001325)1.52479049
181Cutaneous finger syndactyly (HP:0010554)1.51572477
182Aplasia/Hypoplasia of the hallux (HP:0008362)1.51414196
183Osteomalacia (HP:0002749)1.49725335
184Aplasia/Hypoplasia of the uvula (HP:0010293)1.49325428

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.33262625
2NTRK34.38574984
3MAP3K43.03148239
4CASK2.94905214
5MAP2K72.82004597
6RIPK42.77398364
7CAMK1D2.66974628
8NTRK22.65433012
9ZAK2.62036959
10CDC72.41982756
11MAP2K42.31561635
12MAP3K92.20606757
13TTK2.19440059
14MINK12.17402492
15OBSCN2.07005144
16TNIK1.99981640
17PNCK1.99700125
18MARK11.83795527
19BMPR21.80681861
20PLK21.77519523
21GRK11.73166107
22TLK11.65669537
23LATS11.65362412
24BMPR1B1.58436733
25SRPK11.57016552
26DAPK21.54058901
27MUSK1.53474155
28NTRK11.51625123
29PRKCG1.48463811
30SIK21.47316270
31PAK61.40012397
32KSR11.39293298
33GRK51.38767399
34EIF2AK31.36792819
35MAP3K131.35817536
36CAMK2A1.35328439
37FGR1.34556841
38INSRR1.33561497
39PINK11.29685111
40PLK41.26028042
41ERBB41.23098992
42PHKG11.22570575
43PHKG21.22570575
44PTK2B1.22548038
45CDK51.19623717
46SGK21.19100594
47STK391.18912631
48NME11.15908596
49KSR21.15036101
50MKNK21.14265734
51FES1.14164424
52NUAK11.12952469
53CAMK2B1.12651693
54CDK191.12570261
55SGK4941.11656451
56SGK2231.11656451
57PRPF4B1.11024700
58MAP3K121.09561949
59STK381.08360557
60VRK21.06125043
61ACVR1B1.05704005
62TIE11.05093954
63GRK61.04137869
64MAPK131.04119635
65AURKA1.01066338
66DAPK11.00948149
67EEF2K1.00437387
68PAK30.99370503
69ICK0.98734706
70DYRK1A0.98587884
71CDK120.96661849
72STK160.93849788
73MYLK0.92882692
74AKT30.91842194
75VRK10.90548996
76WNK40.90263363
77MAP3K60.89674976
78CSNK1A1L0.88770633
79ARAF0.87179611
80CSNK1G10.87141175
81PLK30.84560052
82CDK90.84144452
83DYRK20.83969194
84LMTK20.83746810
85CAMK2G0.82392210
86SGK10.77924654
87CAMK2D0.75966036
88BCKDK0.75810889
89BUB10.75633404
90PRKCE0.75570996
91KDR0.75513203
92CDK70.73434520
93FGFR20.73327493
94SGK30.73013865
95CAMK1G0.72571301
96TSSK60.71425359
97TYRO30.71074828
98PLK10.70653716
99BRD40.67866855
100MAP3K70.66968053
101FLT30.66860654
102SIK10.66466494
103MARK20.66046420
104ATR0.65644775
105FRK0.65554510
106LATS20.65148805
107FER0.64548816
108CSNK1G30.62527646
109SIK30.62447185
110PRKCZ0.62350723
111PRKD30.61747389
112CDK30.61368044
113CAMK10.60751889
114CDK80.60229187
115BRSK20.59566691
116RAF10.59417109
117GRK70.59343757
118MAPK120.57439902
119PBK0.57115028
120PRKCQ0.56577824
121CAMKK10.56351159
122TNK20.56337803
123STK30.56158789
124DYRK30.53995498
125* PRKACA0.53639684
126CHEK20.52911063
127RPS6KA50.51870475
128STK38L0.51781476
129CSNK1G20.51359864
130NEK20.51143256
131ATM0.50986957
132CDK180.49719039
133DMPK0.47431272
134ROCK20.47408346
135PRKCA0.47049064
136CDK150.46443134
137RPS6KA30.46348617
138PRKCI0.46122807
139TAF10.45481235
140PRKACG0.45077791
141CSNK1E0.45027512
142CDK140.43378185
143MKNK10.43293844
144MTOR0.42975904
145PRKG10.42864010
146CDK10.42132252
147CDK20.41809193
148ADRBK10.41603149
149CHEK10.41525160
150PAK20.41015979
151PKN10.40095270
152BRAF0.38265838
153MAP2K10.37128600
154MAPK100.37064110
155STK110.36833963
156RET0.36206802
157WNK30.35956056
158CDK11A0.35811450
159NEK60.34079143
160PRKCB0.32809052
161UHMK10.32150142

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.77696125
2Nitrogen metabolism_Homo sapiens_hsa009103.60169580
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.47755952
4GABAergic synapse_Homo sapiens_hsa047272.31950738
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.26908943
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.23514462
7Glutamatergic synapse_Homo sapiens_hsa047242.17729107
8Vitamin B6 metabolism_Homo sapiens_hsa007502.15010614
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.03680230
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.03603522
11Arginine biosynthesis_Homo sapiens_hsa002202.02869372
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.00121392
13Circadian entrainment_Homo sapiens_hsa047131.94840063
14Basal transcription factors_Homo sapiens_hsa030221.93545060
15Butanoate metabolism_Homo sapiens_hsa006501.88147870
16Morphine addiction_Homo sapiens_hsa050321.86559480
17Salivary secretion_Homo sapiens_hsa049701.84800248
18Long-term potentiation_Homo sapiens_hsa047201.82788053
19RNA polymerase_Homo sapiens_hsa030201.81784490
20Selenocompound metabolism_Homo sapiens_hsa004501.74364984
21Mismatch repair_Homo sapiens_hsa034301.73372287
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.71763435
23Amphetamine addiction_Homo sapiens_hsa050311.71364597
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.71005898
25Taste transduction_Homo sapiens_hsa047421.70533439
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.67079672
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.62507235
28RNA transport_Homo sapiens_hsa030131.60847675
29Synaptic vesicle cycle_Homo sapiens_hsa047211.60578904
30Olfactory transduction_Homo sapiens_hsa047401.57857368
31RNA degradation_Homo sapiens_hsa030181.57721120
32* Bile secretion_Homo sapiens_hsa049761.44362639
33mRNA surveillance pathway_Homo sapiens_hsa030151.42816314
34* Insulin secretion_Homo sapiens_hsa049111.38210962
35Calcium signaling pathway_Homo sapiens_hsa040201.37015990
36Oocyte meiosis_Homo sapiens_hsa041141.35621998
37DNA replication_Homo sapiens_hsa030301.35322862
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.33574321
39Dopaminergic synapse_Homo sapiens_hsa047281.33110323
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32595143
41Fatty acid biosynthesis_Homo sapiens_hsa000611.31527277
42Fatty acid degradation_Homo sapiens_hsa000711.31257863
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.30114924
44Fatty acid metabolism_Homo sapiens_hsa012121.29934218
45Renin secretion_Homo sapiens_hsa049241.28633318
46Cell cycle_Homo sapiens_hsa041101.28084155
47Gastric acid secretion_Homo sapiens_hsa049711.25610878
48Complement and coagulation cascades_Homo sapiens_hsa046101.24067620
49Tryptophan metabolism_Homo sapiens_hsa003801.18205479
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.18113995
51Propanoate metabolism_Homo sapiens_hsa006401.16503347
52Base excision repair_Homo sapiens_hsa034101.16451068
53Homologous recombination_Homo sapiens_hsa034401.15929586
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13285846
55* Serotonergic synapse_Homo sapiens_hsa047261.11918589
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11225976
57Fanconi anemia pathway_Homo sapiens_hsa034601.09216518
58PPAR signaling pathway_Homo sapiens_hsa033201.08182189
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07216331
60Peroxisome_Homo sapiens_hsa041461.06714311
61Vitamin digestion and absorption_Homo sapiens_hsa049771.06240413
62Long-term depression_Homo sapiens_hsa047301.06033907
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04159356
64cAMP signaling pathway_Homo sapiens_hsa040240.98469578
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97349174
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95412491
67Ovarian steroidogenesis_Homo sapiens_hsa049130.95051295
68Cocaine addiction_Homo sapiens_hsa050300.94827911
69Lysine degradation_Homo sapiens_hsa003100.94376779
70One carbon pool by folate_Homo sapiens_hsa006700.93587621
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.91979340
72Cholinergic synapse_Homo sapiens_hsa047250.91389395
73Cardiac muscle contraction_Homo sapiens_hsa042600.89081477
74Oxytocin signaling pathway_Homo sapiens_hsa049210.88361934
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87280366
76beta-Alanine metabolism_Homo sapiens_hsa004100.86952360
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85045515
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84223222
79Collecting duct acid secretion_Homo sapiens_hsa049660.83528965
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81564837
81Huntingtons disease_Homo sapiens_hsa050160.81169544
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80988360
83Nucleotide excision repair_Homo sapiens_hsa034200.78403087
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77934979
85Pyruvate metabolism_Homo sapiens_hsa006200.74515665
86Parkinsons disease_Homo sapiens_hsa050120.74180654
87Adherens junction_Homo sapiens_hsa045200.72233003
88Alcoholism_Homo sapiens_hsa050340.71533260
89Fatty acid elongation_Homo sapiens_hsa000620.70836551
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69744805
91GnRH signaling pathway_Homo sapiens_hsa049120.69146390
92Spliceosome_Homo sapiens_hsa030400.68202312
93Tight junction_Homo sapiens_hsa045300.67832748
94Purine metabolism_Homo sapiens_hsa002300.67516231
95Chemical carcinogenesis_Homo sapiens_hsa052040.66741954
96Gap junction_Homo sapiens_hsa045400.65168676
97Pancreatic secretion_Homo sapiens_hsa049720.64405915
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63314216
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62214085
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61701887
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61538432
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60716018
103Wnt signaling pathway_Homo sapiens_hsa043100.59972115
104Carbon metabolism_Homo sapiens_hsa012000.59742191
105Hippo signaling pathway_Homo sapiens_hsa043900.59017183
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58936385
107Circadian rhythm_Homo sapiens_hsa047100.58758505
108Glycerolipid metabolism_Homo sapiens_hsa005610.58675504
109Tyrosine metabolism_Homo sapiens_hsa003500.58324177
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57378595
111Hedgehog signaling pathway_Homo sapiens_hsa043400.57095464
112Glucagon signaling pathway_Homo sapiens_hsa049220.56806876
113Steroid biosynthesis_Homo sapiens_hsa001000.55571373
114Histidine metabolism_Homo sapiens_hsa003400.55390455
115Phenylalanine metabolism_Homo sapiens_hsa003600.55217990
116Axon guidance_Homo sapiens_hsa043600.54929602
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54331419
118Thyroid hormone synthesis_Homo sapiens_hsa049180.53661022
119Dilated cardiomyopathy_Homo sapiens_hsa054140.53202176
120Alzheimers disease_Homo sapiens_hsa050100.52836055
121Pyrimidine metabolism_Homo sapiens_hsa002400.52706141
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52371713
123TGF-beta signaling pathway_Homo sapiens_hsa043500.51372129
124Caffeine metabolism_Homo sapiens_hsa002320.50847338
125Melanogenesis_Homo sapiens_hsa049160.50420146
126Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50243801
127Retinol metabolism_Homo sapiens_hsa008300.49957305
128Non-homologous end-joining_Homo sapiens_hsa034500.49894193
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.49644829
130Metabolic pathways_Homo sapiens_hsa011000.48836450
131Biosynthesis of amino acids_Homo sapiens_hsa012300.47819530
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.47360853
133Phototransduction_Homo sapiens_hsa047440.47230722
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.45465101
135ABC transporters_Homo sapiens_hsa020100.45274281
136Sulfur metabolism_Homo sapiens_hsa009200.44801504
137Dorso-ventral axis formation_Homo sapiens_hsa043200.44750956
138Mineral absorption_Homo sapiens_hsa049780.44145580
139African trypanosomiasis_Homo sapiens_hsa051430.43848387
140Oxidative phosphorylation_Homo sapiens_hsa001900.43166420
141Arginine and proline metabolism_Homo sapiens_hsa003300.42457267
142Starch and sucrose metabolism_Homo sapiens_hsa005000.42424004
143Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42352828
144Choline metabolism in cancer_Homo sapiens_hsa052310.41987402
145Estrogen signaling pathway_Homo sapiens_hsa049150.40283132

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