KCNN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)5.89289888
2presynaptic membrane organization (GO:0097090)5.15956004
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.90380890
4central nervous system myelination (GO:0022010)4.77244517
5axon ensheathment in central nervous system (GO:0032291)4.77244517
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.72395884
7locomotory exploration behavior (GO:0035641)4.69149230
8synaptic vesicle maturation (GO:0016188)4.46944787
9synaptic vesicle exocytosis (GO:0016079)4.36570579
10vocalization behavior (GO:0071625)4.06777780
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.96209047
12neuron cell-cell adhesion (GO:0007158)3.95292427
13establishment of nucleus localization (GO:0040023)3.91396250
14regulation of synapse structural plasticity (GO:0051823)3.90660281
15glutamate secretion (GO:0014047)3.85948404
16cerebral cortex radially oriented cell migration (GO:0021799)3.84935249
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.84073724
18regulation of synaptic vesicle exocytosis (GO:2000300)3.83518303
19regulation of glutamate receptor signaling pathway (GO:1900449)3.75990307
20regulation of neurotransmitter uptake (GO:0051580)3.74400370
21proline transport (GO:0015824)3.70203968
22prepulse inhibition (GO:0060134)3.69247247
23membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.69155363
24neurotransmitter secretion (GO:0007269)3.68743645
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.62538866
26regulation of long-term neuronal synaptic plasticity (GO:0048169)3.62262572
27L-amino acid import (GO:0043092)3.59474213
28C4-dicarboxylate transport (GO:0015740)3.58992041
29exploration behavior (GO:0035640)3.57917338
30response to auditory stimulus (GO:0010996)3.57388475
31regulation of neuronal synaptic plasticity (GO:0048168)3.56952149
32ionotropic glutamate receptor signaling pathway (GO:0035235)3.48018405
33behavioral response to nicotine (GO:0035095)3.47024385
34cellular potassium ion homeostasis (GO:0030007)3.46407902
35auditory behavior (GO:0031223)3.42861926
36pyrimidine nucleobase catabolic process (GO:0006208)3.39579315
37regulation of synaptic vesicle transport (GO:1902803)3.36741777
38synaptic vesicle docking involved in exocytosis (GO:0016081)3.36722460
39gamma-aminobutyric acid transport (GO:0015812)3.36664319
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.35809435
41neurotransmitter uptake (GO:0001504)3.35286542
42alanine transport (GO:0032328)3.32216397
43myelination in peripheral nervous system (GO:0022011)3.31648419
44peripheral nervous system axon ensheathment (GO:0032292)3.31648419
45layer formation in cerebral cortex (GO:0021819)3.27514106
46astrocyte development (GO:0014002)3.27400296
47cellular sodium ion homeostasis (GO:0006883)3.27229832
48innervation (GO:0060384)3.26844451
49cellular response to nerve growth factor stimulus (GO:1990090)3.25194198
50response to nerve growth factor (GO:1990089)3.25194198
51neurotransmitter-gated ion channel clustering (GO:0072578)3.23935582
52response to histamine (GO:0034776)3.22924187
53central nervous system projection neuron axonogenesis (GO:0021952)3.19970155
54sodium ion export (GO:0071436)3.19930132
55activation of protein kinase A activity (GO:0034199)3.18930480
56neurotransmitter transport (GO:0006836)3.18489051
57transmission of nerve impulse (GO:0019226)3.18290291
58positive regulation of synaptic transmission, GABAergic (GO:0032230)3.17762446
59dendritic spine morphogenesis (GO:0060997)3.17152251
60neuronal action potential propagation (GO:0019227)3.17121777
61cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.16280020
62somite development (GO:0061053)3.13907175
63tongue development (GO:0043586)3.12785717
64glutamate receptor signaling pathway (GO:0007215)3.11913960
65synaptic transmission, glutamatergic (GO:0035249)3.11107602
66cell communication by electrical coupling (GO:0010644)3.09228036
67long-term memory (GO:0007616)3.08588166
68regulation of neurotransmitter levels (GO:0001505)3.08543911
69protein localization to synapse (GO:0035418)3.08251861
70positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.07802628
71photoreceptor cell differentiation (GO:0046530)3.07692025
72eye photoreceptor cell differentiation (GO:0001754)3.07692025
73neuron-neuron synaptic transmission (GO:0007270)3.07465025
74positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.07193710
75astrocyte differentiation (GO:0048708)3.07066160
76regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.06384955
77regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.05059624
78potassium ion homeostasis (GO:0055075)3.03230711
79neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.02397041
80regulation of vesicle fusion (GO:0031338)3.02128986
81positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.01890724
82regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.00606784
83regulation of heat generation (GO:0031650)3.00571117
84positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.98379479
85regulation of synaptic transmission, glutamatergic (GO:0051966)2.97163113
86negative regulation of cytosolic calcium ion concentration (GO:0051481)2.96953157
87striatum development (GO:0021756)2.96458614
88mating behavior (GO:0007617)2.95269339
89postsynaptic membrane organization (GO:0001941)2.93780098
90dendrite morphogenesis (GO:0048813)2.92611258
91positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.92521733
92phenol-containing compound catabolic process (GO:0019336)2.91299614
93dermatan sulfate biosynthetic process (GO:0030208)2.90336231
94catecholamine transport (GO:0051937)2.87284667
95cAMP-mediated signaling (GO:0019933)2.86851950
96negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.86724050
97detection of calcium ion (GO:0005513)2.86102774
98positive regulation of synapse assembly (GO:0051965)2.85380300
99dopamine transport (GO:0015872)2.84930869
100membrane assembly (GO:0071709)2.84787354
101regulation of membrane repolarization (GO:0060306)2.84760729
102negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.84528451
103regulation of excitatory postsynaptic membrane potential (GO:0060079)2.83767064
104G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.82272428
105regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.80708783
106axonal fasciculation (GO:0007413)2.80191043
107neuronal ion channel clustering (GO:0045161)2.79206048
108response to inactivity (GO:0014854)2.78892551
109cerebellar Purkinje cell layer development (GO:0021680)2.78059875
110suckling behavior (GO:0001967)2.77458180
111potassium ion import (GO:0010107)2.77185378
112nucleus localization (GO:0051647)2.75790536
113neuromuscular process controlling posture (GO:0050884)2.75725592
114regulation of postsynaptic membrane potential (GO:0060078)2.75305006
115negative regulation of nucleotide biosynthetic process (GO:0030809)2.75068099
116negative regulation of purine nucleotide biosynthetic process (GO:1900372)2.75068099
117neuron recognition (GO:0008038)2.74737924
118long-term synaptic potentiation (GO:0060291)2.74438957
119synaptic vesicle endocytosis (GO:0048488)2.73567641
120amino acid import (GO:0043090)2.73545753
121insulin secretion (GO:0030073)2.73498126
122adult walking behavior (GO:0007628)2.73370122
123neuromuscular process controlling balance (GO:0050885)2.73038813
124positive regulation of potassium ion transport (GO:0043268)2.72194607
125establishment of mitochondrion localization (GO:0051654)2.72107753
126nonmotile primary cilium assembly (GO:0035058)2.71320318
127cyclic-nucleotide-mediated signaling (GO:0019935)2.71103908
128regulation of synaptic plasticity (GO:0048167)2.70980491
129synapse assembly (GO:0007416)2.70320131
130G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.69871492
131acidic amino acid transport (GO:0015800)2.69696276
132regulation of ARF protein signal transduction (GO:0032012)2.69630566
133synaptic transmission, dopaminergic (GO:0001963)2.69432669
134regulation of respiratory system process (GO:0044065)2.68662534
135cerebellar Purkinje cell differentiation (GO:0021702)2.68447978
136positive regulation of potassium ion transmembrane transport (GO:1901381)2.68377392
137membrane depolarization during action potential (GO:0086010)2.67873398
138cellular response to cholesterol (GO:0071397)2.67413189
139substrate-independent telencephalic tangential migration (GO:0021826)2.67222872
140substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.67222872
141regulation of potassium ion transmembrane transporter activity (GO:1901016)2.66919165
142positive regulation of vesicle fusion (GO:0031340)2.66203775
143neurotransmitter catabolic process (GO:0042135)2.66064331
144positive regulation of membrane potential (GO:0045838)2.65576292
145synaptic transmission, cholinergic (GO:0007271)2.65573399
146regulation of voltage-gated calcium channel activity (GO:1901385)2.65333181
147negative regulation of astrocyte differentiation (GO:0048712)2.64999006
148serotonin metabolic process (GO:0042428)2.64658304
149vesicle transport along microtubule (GO:0047496)2.64442567
150dopamine biosynthetic process (GO:0042416)2.63030428
151regulation of calcium ion-dependent exocytosis (GO:0017158)2.62989914
152negative regulation of neurotransmitter transport (GO:0051589)2.62674771
153behavioral response to cocaine (GO:0048148)2.61063910
154regulation of dopamine metabolic process (GO:0042053)2.60750422
155regulation of catecholamine metabolic process (GO:0042069)2.60750422
156mechanosensory behavior (GO:0007638)2.60616390
157regulation of neurotransmitter transport (GO:0051588)2.58959684

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.96242599
2* GBX2_23144817_ChIP-Seq_PC3_Human3.08575608
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93997563
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.89865602
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.64225813
6DROSHA_22980978_ChIP-Seq_HELA_Human2.51959557
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44168613
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42627548
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41668812
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.40482402
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39300644
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38465923
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38465923
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37013238
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36902465
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.31777014
17REST_21632747_ChIP-Seq_MESCs_Mouse2.31655614
18* RARB_27405468_Chip-Seq_BRAIN_Mouse2.14479687
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.08975323
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.06545780
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03683967
22IGF1R_20145208_ChIP-Seq_DFB_Human2.01912337
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99541575
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.97962418
25IKZF1_21737484_ChIP-ChIP_HCT116_Human1.84852655
26AR_21572438_ChIP-Seq_LNCaP_Human1.82063240
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.78404363
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.73820891
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73420669
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66469604
31* SMAD4_21799915_ChIP-Seq_A2780_Human1.64636799
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63733020
33VDR_22108803_ChIP-Seq_LS180_Human1.60955278
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59903871
35NR3C1_23031785_ChIP-Seq_PC12_Mouse1.56623689
36* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53109241
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52774260
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.50898514
39ZNF274_21170338_ChIP-Seq_K562_Hela1.50231253
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49016292
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47807095
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46553721
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.43732680
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43262118
45* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40686102
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.40148610
47TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35835607
48* SOX2_21211035_ChIP-Seq_LN229_Gbm1.33962212
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.33687855
50P300_19829295_ChIP-Seq_ESCs_Human1.33541899
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33231432
52RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.32857752
53FUS_26573619_Chip-Seq_HEK293_Human1.30952388
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30850360
55* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30723593
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.30549580
57EWS_26573619_Chip-Seq_HEK293_Human1.29949240
58* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28649131
59STAT3_23295773_ChIP-Seq_U87_Human1.28566527
60RING1B_27294783_Chip-Seq_ESCs_Mouse1.28373115
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28347611
62AR_19668381_ChIP-Seq_PC3_Human1.26481232
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25981097
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25183457
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25183457
66ER_23166858_ChIP-Seq_MCF-7_Human1.24503753
67AR_25329375_ChIP-Seq_VCAP_Human1.22213884
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21940103
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21748512
70ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21658708
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19466264
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19465729
73TAF15_26573619_Chip-Seq_HEK293_Human1.19087942
74RNF2_27304074_Chip-Seq_NSC_Mouse1.17504199
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17255615
76* NANOG_18555785_Chip-Seq_ESCs_Mouse1.17126549
77AHR_22903824_ChIP-Seq_MCF-7_Human1.16512085
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16377284
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16240690
80SALL1_21062744_ChIP-ChIP_HESCs_Human1.14532726
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.14330966
82HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14051432
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.13997141
84* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13829007
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13009497
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12847784
87* TP53_16413492_ChIP-PET_HCT116_Human1.12832446
88BCAT_22108803_ChIP-Seq_LS180_Human1.11810217
89* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11523723
90TCF4_23295773_ChIP-Seq_U87_Human1.10425600
91* CBP_20019798_ChIP-Seq_JUKART_Human1.10375491
92* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10375491
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07645704
94SOX9_26525672_Chip-Seq_HEART_Mouse1.06823576
95RXR_22108803_ChIP-Seq_LS180_Human1.05315552
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04863136
97* TP53_18474530_ChIP-ChIP_U2OS_Human1.04195543
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04169164
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03588319
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.03357694
101* P53_22387025_ChIP-Seq_ESCs_Mouse1.02913991
102TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02061086
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00957757
104* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00725250
105* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00718650
106POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00439977
107* RUNX2_22187159_ChIP-Seq_PCA_Human0.99931914
108CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99421464
109RING1B_27294783_Chip-Seq_NPCs_Mouse0.98813706
110* SMAD3_21741376_ChIP-Seq_ESCs_Human0.96930339
111WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96758673
112BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96707891
113EP300_21415370_ChIP-Seq_HL-1_Mouse0.96690507
114* SMAD4_21741376_ChIP-Seq_HESCs_Human0.96540233
115* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96332329
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95151067
117P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95014322
118KDM2B_26808549_Chip-Seq_K562_Human0.92662436
119TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92030064
120CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90302905
121PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90155698
122LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89666044
123MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89525483
124UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87758048
125OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86928404
126SMAD3_21741376_ChIP-Seq_HESCs_Human0.86798015
127SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86324987
128* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85643676
129* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83904464

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.92177541
2MP0003635_abnormal_synaptic_transmissio3.56034582
3MP0003880_abnormal_central_pattern3.50967548
4MP0004270_analgesia3.44259885
5MP0002822_catalepsy3.13845701
6MP0003136_yellow_coat_color2.99376662
7MP0002909_abnormal_adrenal_gland2.93594847
8MP0009745_abnormal_behavioral_response2.84732806
9MP0009046_muscle_twitch2.77042516
10MP0002063_abnormal_learning/memory/cond2.69038354
11MP0002064_seizures2.64076476
12MP0009780_abnormal_chondrocyte_physiolo2.63193386
13MP0002653_abnormal_ependyma_morphology2.54706486
14MP0002572_abnormal_emotion/affect_behav2.51280007
15MP0001501_abnormal_sleep_pattern2.41676604
16MP0005423_abnormal_somatic_nervous2.41588905
17MP0001486_abnormal_startle_reflex2.30339570
18MP0005646_abnormal_pituitary_gland2.21876450
19MP0002734_abnormal_mechanical_nocicepti2.20560210
20MP0003122_maternal_imprinting2.09402528
21MP0002272_abnormal_nervous_system2.05140406
22MP0005645_abnormal_hypothalamus_physiol2.04505372
23MP0001968_abnormal_touch/_nociception2.02234653
24MP0000013_abnormal_adipose_tissue2.01813375
25MP0004858_abnormal_nervous_system1.89689127
26MP0002733_abnormal_thermal_nociception1.89243525
27MP0001529_abnormal_vocalization1.85781552
28MP0006276_abnormal_autonomic_nervous1.80927431
29MP0002557_abnormal_social/conspecific_i1.77708546
30MP0001502_abnormal_circadian_rhythm1.76632012
31MP0005386_behavior/neurological_phenoty1.75641585
32MP0004924_abnormal_behavior1.75641585
33MP0001440_abnormal_grooming_behavior1.67460289
34MP0001970_abnormal_pain_threshold1.65427027
35MP0003283_abnormal_digestive_organ1.64487362
36MP0004885_abnormal_endolymph1.61773806
37MP0001905_abnormal_dopamine_level1.60374935
38MP0002067_abnormal_sensory_capabilities1.58893222
39MP0008569_lethality_at_weaning1.55309022
40MP0003183_abnormal_peptide_metabolism1.43096130
41MP0002184_abnormal_innervation1.41565954
42MP0003329_amyloid_beta_deposits1.40863954
43MP0002736_abnormal_nociception_after1.40393959
44MP0000955_abnormal_spinal_cord1.40193568
45MP0010386_abnormal_urinary_bladder1.39253596
46MP0000569_abnormal_digit_pigmentation1.38518209
47MP0000778_abnormal_nervous_system1.35998751
48MP0008961_abnormal_basal_metabolism1.35797110
49MP0004811_abnormal_neuron_physiology1.34763832
50MP0001984_abnormal_olfaction1.33887260
51MP0003633_abnormal_nervous_system1.33432917
52MP0001299_abnormal_eye_distance/1.31045747
53MP0005253_abnormal_eye_physiology1.30751973
54MP0000026_abnormal_inner_ear1.29916302
55MP0005379_endocrine/exocrine_gland_phen1.29354914
56MP0003787_abnormal_imprinting1.28675591
57MP0000751_myopathy1.27920783
58MP0005171_absent_coat_pigmentation1.27622156
59MP0003690_abnormal_glial_cell1.26606442
60MP0005167_abnormal_blood-brain_barrier1.22801817
61MP0001963_abnormal_hearing_physiology1.21063484
62MP0002638_abnormal_pupillary_reflex1.20926055
63MP0002066_abnormal_motor_capabilities/c1.20648436
64MP0002882_abnormal_neuron_morphology1.20124623
65MP0000920_abnormal_myelination1.16490561
66MP0004145_abnormal_muscle_electrophysio1.16184676
67MP0002837_dystrophic_cardiac_calcinosis1.14782751
68MP0002735_abnormal_chemical_nociception1.14383393
69MP0000631_abnormal_neuroendocrine_gland1.10752957
70MP0001986_abnormal_taste_sensitivity1.07183847
71MP0002752_abnormal_somatic_nervous1.07032679
72MP0004043_abnormal_pH_regulation1.06798899
73MP0004742_abnormal_vestibular_system1.06761637
74MP0005535_abnormal_body_temperature1.06654129
75MP0003631_nervous_system_phenotype1.06552845
76MP0003634_abnormal_glial_cell1.05615745
77MP0001188_hyperpigmentation1.04593090
78MP0000049_abnormal_middle_ear1.00998452
79MP0003879_abnormal_hair_cell0.97804411
80MP0003172_abnormal_lysosome_physiology0.97366771
81MP0002090_abnormal_vision0.95694412
82MP0002751_abnormal_autonomic_nervous0.95630569
83MP0002152_abnormal_brain_morphology0.92862011
84MP0005248_abnormal_Harderian_gland0.92822227
85MP0000749_muscle_degeneration0.89853258
86MP0002069_abnormal_eating/drinking_beha0.89091091
87MP0003646_muscle_fatigue0.88982465
88MP0004085_abnormal_heartbeat0.87696303
89MP0003075_altered_response_to0.86918710
90MP0002233_abnormal_nose_morphology0.86304631
91MP0003938_abnormal_ear_development0.86202185
92MP0002693_abnormal_pancreas_physiology0.85681723
93MP0005394_taste/olfaction_phenotype0.85360103
94MP0005499_abnormal_olfactory_system0.85360103
95MP0003861_abnormal_nervous_system0.83631305
96MP0001944_abnormal_pancreas_morphology0.82037117
97MP0003632_abnormal_nervous_system0.81155451
98MP0001664_abnormal_digestion0.79325307
99MP0001177_atelectasis0.79030716
100MP0002229_neurodegeneration0.78929241
101MP0006072_abnormal_retinal_apoptosis0.77993437
102MP0004142_abnormal_muscle_tone0.76799731
103MP0002249_abnormal_larynx_morphology0.76195447
104MP0005187_abnormal_penis_morphology0.74267379
105MP0000003_abnormal_adipose_tissue0.72293837
106MP0002254_reproductive_system_inflammat0.72258588
107MP0008872_abnormal_physiological_respon0.71828008
108MP0008789_abnormal_olfactory_epithelium0.71017422
109MP0002234_abnormal_pharynx_morphology0.70011185
110MP0004130_abnormal_muscle_cell0.69959280
111MP0004215_abnormal_myocardial_fiber0.69370819
112MP0002102_abnormal_ear_morphology0.68575897
113MP0005620_abnormal_muscle_contractility0.67834134
114MP0000613_abnormal_salivary_gland0.67170989
115MP0003045_fibrosis0.66905950
116MP0008874_decreased_physiological_sensi0.66483617
117MP0006292_abnormal_olfactory_placode0.66167774
118MP0000534_abnormal_ureter_morphology0.65442813
119MP0005551_abnormal_eye_electrophysiolog0.65031844
120MP0003137_abnormal_impulse_conducting0.64208343
121* MP0001943_abnormal_respiration0.63819204
122MP0002095_abnormal_skin_pigmentation0.63585068
123MP0001270_distended_abdomen0.63000475
124MP0005409_darkened_coat_color0.62986569
125MP0002078_abnormal_glucose_homeostasis0.62725411
126MP0001485_abnormal_pinna_reflex0.61779512
127MP0000747_muscle_weakness0.61341927
128MP0002108_abnormal_muscle_morphology0.58501285
129MP0005623_abnormal_meninges_morphology0.58362703

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.43876249
2Myokymia (HP:0002411)4.67978587
3Visual hallucinations (HP:0002367)4.33262565
4Focal seizures (HP:0007359)4.30132862
5Limb dystonia (HP:0002451)3.81831434
6Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.61783047
7Supranuclear gaze palsy (HP:0000605)3.60230754
8Action tremor (HP:0002345)3.52633769
9Neurofibrillary tangles (HP:0002185)3.49714108
10Epileptic encephalopathy (HP:0200134)3.36795255
11Cerebral inclusion bodies (HP:0100314)3.34408475
12Megalencephaly (HP:0001355)3.27042829
13Progressive cerebellar ataxia (HP:0002073)3.24811201
14Aplasia involving bones of the extremities (HP:0009825)3.09600831
15Aplasia involving bones of the upper limbs (HP:0009823)3.09600831
16Aplasia of the phalanges of the hand (HP:0009802)3.09600831
17Generalized tonic-clonic seizures (HP:0002069)3.07203596
18Papilledema (HP:0001085)3.01281480
19Pheochromocytoma (HP:0002666)2.92235867
20Abnormality of calcium-phosphate metabolism (HP:0100530)2.89408714
21Abnormality of the labia minora (HP:0012880)2.88453311
22Anxiety (HP:0000739)2.88150885
23Depression (HP:0000716)2.87717775
24Fetal akinesia sequence (HP:0001989)2.86891082
25Absent/shortened dynein arms (HP:0200106)2.80498878
26Dynein arm defect of respiratory motile cilia (HP:0012255)2.80498878
27Abnormality of the diencephalon (HP:0010662)2.78259067
28Postural instability (HP:0002172)2.73201608
29Inability to walk (HP:0002540)2.72598663
30Absence seizures (HP:0002121)2.68841836
31Hemiparesis (HP:0001269)2.65817078
32Agitation (HP:0000713)2.65169499
33True hermaphroditism (HP:0010459)2.63865249
34Ankle clonus (HP:0011448)2.58466618
35Pancreatic fibrosis (HP:0100732)2.58193914
36Gait imbalance (HP:0002141)2.56550873
37Increased circulating renin level (HP:0000848)2.56279150
38Truncal ataxia (HP:0002078)2.52452603
39Split foot (HP:0001839)2.52380019
40Atonic seizures (HP:0010819)2.49264782
41Dialeptic seizures (HP:0011146)2.48619047
42Dysdiadochokinesis (HP:0002075)2.48149739
43EEG with generalized epileptiform discharges (HP:0011198)2.47530998
44Abnormality of the ischium (HP:0003174)2.46863937
45Epileptiform EEG discharges (HP:0011182)2.45418354
46Febrile seizures (HP:0002373)2.45006761
47Conical tooth (HP:0000698)2.44897911
48Abnormality of midbrain morphology (HP:0002418)2.42545662
49Molar tooth sign on MRI (HP:0002419)2.42545662
50Hypsarrhythmia (HP:0002521)2.40885338
51Abnormal respiratory epithelium morphology (HP:0012253)2.40281661
52Abnormal respiratory motile cilium morphology (HP:0005938)2.40281661
53Long nose (HP:0003189)2.39022630
54Neoplasm of the oral cavity (HP:0100649)2.37237354
55Neuroendocrine neoplasm (HP:0100634)2.36364276
56Abnormal eating behavior (HP:0100738)2.34889018
57Abnormality of the 4th metacarpal (HP:0010012)2.34633039
58Abnormality of binocular vision (HP:0011514)2.33156374
59Diplopia (HP:0000651)2.33156374
60Hypoventilation (HP:0002791)2.33135103
61Medial flaring of the eyebrow (HP:0010747)2.32810866
62Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.30322780
63Bilateral microphthalmos (HP:0007633)2.27695248
64Akinesia (HP:0002304)2.27212276
65Absent speech (HP:0001344)2.26736827
66Pancreatic cysts (HP:0001737)2.26506451
67Failure to thrive in infancy (HP:0001531)2.25128128
68Type II lissencephaly (HP:0007260)2.23893578
69Lissencephaly (HP:0001339)2.22977913
70Postural tremor (HP:0002174)2.22212067
71Impaired smooth pursuit (HP:0007772)2.21911150
72Excessive salivation (HP:0003781)2.21515269
73Drooling (HP:0002307)2.21515269
74Abnormal pancreas size (HP:0012094)2.21251852
75Short 4th metacarpal (HP:0010044)2.20045715
76Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.20045715
77Broad-based gait (HP:0002136)2.19659971
78Bronchomalacia (HP:0002780)2.19439688
79Annular pancreas (HP:0001734)2.18024067
80Macroorchidism (HP:0000053)2.17467480
81Hyperinsulinemic hypoglycemia (HP:0000825)2.17181208
82Prolonged QT interval (HP:0001657)2.16838102
83Torticollis (HP:0000473)2.16161163
84Hemiplegia (HP:0002301)2.15267684
85Poor eye contact (HP:0000817)2.15105628
86Urinary bladder sphincter dysfunction (HP:0002839)2.14275233
87Pachygyria (HP:0001302)2.12980360
88Myotonia (HP:0002486)2.12328650
89Oligodactyly (hands) (HP:0001180)2.12322290
90Abnormality of the corticospinal tract (HP:0002492)2.11787629
91Bradykinesia (HP:0002067)2.10751322
92Dysmetria (HP:0001310)2.10360304
93Genetic anticipation (HP:0003743)2.08588082
94Abnormal respiratory motile cilium physiology (HP:0012261)2.05397260
95Aplasia/Hypoplasia of the spleen (HP:0010451)2.05170451
96Morphological abnormality of the pyramidal tract (HP:0002062)2.04949614
97Impaired social interactions (HP:0000735)2.04457783
98Abnormal social behavior (HP:0012433)2.04457783
99Hypokalemic alkalosis (HP:0001949)2.04264772
100Rigidity (HP:0002063)2.03745314
101Congenital primary aphakia (HP:0007707)2.02789225
102Hypoplastic ischia (HP:0003175)2.02615491
103Hypothermia (HP:0002045)2.01343568
104Nephrogenic diabetes insipidus (HP:0009806)2.00525534
105Hypercortisolism (HP:0001578)2.00221543
106Protruding tongue (HP:0010808)2.00044829
107Hepatoblastoma (HP:0002884)1.98333900
108Intention tremor (HP:0002080)1.97603053
109Clumsiness (HP:0002312)1.97207573
110Stereotypic behavior (HP:0000733)1.96796351
111Rapidly progressive (HP:0003678)1.96555501
112Neoplasm of the heart (HP:0100544)1.94760554
113Nephronophthisis (HP:0000090)1.94611400
114Anophthalmia (HP:0000528)1.93429442
115Abnormality of ocular smooth pursuit (HP:0000617)1.93086594
116Hyperventilation (HP:0002883)1.88840396
117Hypoglycemic seizures (HP:0002173)1.88670717
118Chronic hepatic failure (HP:0100626)1.88298838
119Resting tremor (HP:0002322)1.88042399
120Retinal dysplasia (HP:0007973)1.87590673
121Abnormal EKG (HP:0003115)1.87056749
122Impaired vibration sensation in the lower limbs (HP:0002166)1.86147331
123Lower limb muscle weakness (HP:0007340)1.84711515
124Genital tract atresia (HP:0001827)1.83697182
125Polyphagia (HP:0002591)1.83052237
126Metabolic alkalosis (HP:0200114)1.81710469
127Gaze-evoked nystagmus (HP:0000640)1.81411965
128Cutaneous finger syndactyly (HP:0010554)1.81277001
129Psychosis (HP:0000709)1.81123028
130Mutism (HP:0002300)1.80673571
131Exercise-induced muscle cramps (HP:0003710)1.78745009
132Neuronal loss in central nervous system (HP:0002529)1.78592681
133Vaginal atresia (HP:0000148)1.78264900
134Focal dystonia (HP:0004373)1.78164308
135Ventricular fibrillation (HP:0001663)1.76509045
136Retinal atrophy (HP:0001105)1.76492402
137Oligodactyly (HP:0012165)1.76183724
138Spastic tetraparesis (HP:0001285)1.75983871
139Exercise-induced myalgia (HP:0003738)1.74951264
140Progressive inability to walk (HP:0002505)1.74676625
141Renal hypoplasia (HP:0000089)1.74648799
142Peripheral hypomyelination (HP:0007182)1.74430082
143Amblyopia (HP:0000646)1.74152797
144Morphological abnormality of the inner ear (HP:0011390)1.71976987
145Lower limb amyotrophy (HP:0007210)1.71337294
146Urinary urgency (HP:0000012)1.70484751
147Specific learning disability (HP:0001328)1.69068104
148Degeneration of the lateral corticospinal tracts (HP:0002314)1.68163756
149Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.68163756
150Dysostosis multiplex (HP:0000943)1.67772350
151Large for gestational age (HP:0001520)1.66894796
152Open mouth (HP:0000194)1.65274645
153Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.65203667
154Symptomatic seizures (HP:0011145)1.64068811
155Potter facies (HP:0002009)1.63911364
156Facial shape deformation (HP:0011334)1.63911364
157Blue irides (HP:0000635)1.63801813
158Spastic gait (HP:0002064)1.63618833
159Abnormal ciliary motility (HP:0012262)1.63088501
160Hyperparathyroidism (HP:0000843)1.62771434
161Craniofacial dystonia (HP:0012179)1.62440881

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.21751549
2EPHA43.70338711
3MAP3K93.08391910
4NTRK22.79404245
5PRKD32.58168548
6PINK12.43189080
7NTRK12.40466708
8MARK12.37898881
9INSRR2.33224685
10MAP3K42.33085594
11OBSCN2.19591242
12DAPK22.03994409
13MINK12.01714509
14TAOK32.00371987
15KSR21.93659580
16BCR1.87696664
17BMPR1B1.75516372
18TNIK1.72287771
19PKN11.69950681
20PAK61.67508070
21MAP2K71.66304175
22MAP3K21.58481042
23CAMKK11.56501374
24PHKG11.48626281
25PHKG21.48626281
26GRK51.46381958
27CDK51.45877725
28MAP2K41.42714896
29MAP3K121.36499201
30RIPK41.35583155
31EPHA31.33862729
32LMTK21.32295989
33CDK31.31948184
34PRKCH1.31833327
35CASK1.26749185
36MAPK151.23913464
37WNK31.23858488
38PNCK1.21727192
39CAMKK21.21319183
40CAMK2A1.19074120
41KSR11.16976221
42UHMK11.16382878
43MAPKAPK51.12714306
44MUSK1.11391053
45DYRK21.07674891
46CSNK1G11.06638299
47MAPK131.04363117
48TRIM281.03272224
49MAP3K131.01740002
50SIK21.00428033
51SGK21.00417388
52CSNK1G20.99579956
53PAK30.98959073
54SGK30.98908619
55RET0.98858522
56CAMK1G0.98580943
57FES0.97454235
58CAMK2B0.94975068
59PRKCG0.93351105
60CDC42BPA0.92607084
61STK380.92126127
62TRIB30.91965295
63OXSR10.91012843
64SGK2230.89791443
65SGK4940.89791443
66DAPK10.88902046
67CDK190.88097886
68NEK90.87622254
69MAP3K10.86677853
70GRK70.86223056
71PDGFRA0.86032312
72FGR0.84313945
73ADRBK20.83688397
74CAMK2D0.83504816
75CCNB10.82027297
76ARAF0.80542054
77ROCK20.78791962
78MOS0.76458448
79FRK0.76250329
80TYRO30.75919731
81HIPK20.74137563
82SGK10.73651153
83WNK40.73145662
84MAPK120.72193653
85ADRBK10.70460346
86MAP2K10.68957038
87CSNK1A10.68865100
88CDK150.68548973
89TNK20.68430906
90CDK180.68142555
91PLK20.67362569
92DYRK1A0.67158526
93CSNK1A1L0.67075438
94STK110.66983307
95FGFR20.65721255
96CDK140.65186078
97CAMK2G0.64652950
98DMPK0.63759984
99PTK20.63462325
100CAMK40.63095247
101RPS6KA50.62325500
102WNK10.62191726
103STK390.62073150
104SIK10.62039754
105PRKG10.61263259
106PRKCE0.60130171
107RPS6KA30.59297113
108EPHB10.57762538
109PRPF4B0.57668183
110MARK20.56934036
111CDK11A0.56675045
112PIK3CG0.56544495
113CSNK1G30.53624144
114MAPK100.53050680
115PRKDC0.52413260
116PDPK10.51637764
117GRK10.51376696
118CAMK10.50999447
119PTK2B0.49544522
120LATS20.49535772
121ROCK10.49317212
122FYN0.48806835
123FER0.48691596
124BCKDK0.48562997
125TLK10.48284933
126PIK3CA0.46095144
127PDK10.46052635
128PRKCQ0.45574951
129RIPK10.44772216
130RPS6KA20.44513113
131PRKD20.44075517
132TAOK10.44048126
133TIE10.43662783
134SCYL20.42277498
135CSNK1D0.40771493
136PRKACA0.39944455
137PRKCZ0.39231427
138MAP4K20.38619429
139MAP3K70.38391549
140PRKACB0.32709428
141MAPK70.30394971
142PRKAA10.28091151
143CAMK1D0.27186402

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.82572309
2Cocaine addiction_Homo sapiens_hsa050302.68734041
3Synaptic vesicle cycle_Homo sapiens_hsa047212.65932963
4Amphetamine addiction_Homo sapiens_hsa050312.49561784
5* Insulin secretion_Homo sapiens_hsa049112.44214345
6GABAergic synapse_Homo sapiens_hsa047272.43468083
7Circadian entrainment_Homo sapiens_hsa047132.36857094
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.33159496
9Olfactory transduction_Homo sapiens_hsa047402.24839828
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.21608127
11Morphine addiction_Homo sapiens_hsa050322.14388018
12Long-term potentiation_Homo sapiens_hsa047202.13101491
13Glutamatergic synapse_Homo sapiens_hsa047242.10238212
14Dopaminergic synapse_Homo sapiens_hsa047282.09545414
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.08743729
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.06252449
17Salivary secretion_Homo sapiens_hsa049701.91278819
18Cholinergic synapse_Homo sapiens_hsa047251.84119107
19Serotonergic synapse_Homo sapiens_hsa047261.82070965
20Gastric acid secretion_Homo sapiens_hsa049711.73135736
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71212588
22Butanoate metabolism_Homo sapiens_hsa006501.67851359
23Renin secretion_Homo sapiens_hsa049241.67449443
24Taste transduction_Homo sapiens_hsa047421.62911637
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.61869896
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.61274022
27Caffeine metabolism_Homo sapiens_hsa002321.56897983
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53129277
29Type II diabetes mellitus_Homo sapiens_hsa049301.47257313
30Calcium signaling pathway_Homo sapiens_hsa040201.43083029
31Long-term depression_Homo sapiens_hsa047301.41227291
32Nitrogen metabolism_Homo sapiens_hsa009101.40640105
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39041399
34Oxytocin signaling pathway_Homo sapiens_hsa049211.30816453
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28445175
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28246261
37Dorso-ventral axis formation_Homo sapiens_hsa043201.28117838
38Gap junction_Homo sapiens_hsa045401.27573285
39GnRH signaling pathway_Homo sapiens_hsa049121.27505673
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24056738
41cAMP signaling pathway_Homo sapiens_hsa040241.23014375
42Estrogen signaling pathway_Homo sapiens_hsa049151.22339256
43Collecting duct acid secretion_Homo sapiens_hsa049661.17261088
44Phototransduction_Homo sapiens_hsa047441.16635377
45Vitamin B6 metabolism_Homo sapiens_hsa007501.16075017
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12042916
47Pancreatic secretion_Homo sapiens_hsa049721.09607938
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.08252357
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08223449
50Vibrio cholerae infection_Homo sapiens_hsa051101.06727882
51beta-Alanine metabolism_Homo sapiens_hsa004101.06093892
52Melanogenesis_Homo sapiens_hsa049161.04259245
53Propanoate metabolism_Homo sapiens_hsa006401.01831440
54Thyroid hormone synthesis_Homo sapiens_hsa049181.01695750
55ABC transporters_Homo sapiens_hsa020101.01045050
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00687963
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00549461
58Dilated cardiomyopathy_Homo sapiens_hsa054141.00355136
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.99288500
60Circadian rhythm_Homo sapiens_hsa047100.99068367
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98606227
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95630946
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91310408
64Glioma_Homo sapiens_hsa052140.89002274
65Cardiac muscle contraction_Homo sapiens_hsa042600.88725582
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88572864
67Type I diabetes mellitus_Homo sapiens_hsa049400.88286357
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86207914
69Glucagon signaling pathway_Homo sapiens_hsa049220.82631530
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80180997
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.80065438
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.79437534
73Axon guidance_Homo sapiens_hsa043600.77981729
74ErbB signaling pathway_Homo sapiens_hsa040120.77952432
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75102814
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73818454
77Ether lipid metabolism_Homo sapiens_hsa005650.70332223
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69586705
79Histidine metabolism_Homo sapiens_hsa003400.69093392
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68323622
81Prion diseases_Homo sapiens_hsa050200.66902796
82Fatty acid biosynthesis_Homo sapiens_hsa000610.66614296
83Basal cell carcinoma_Homo sapiens_hsa052170.66467346
84MAPK signaling pathway_Homo sapiens_hsa040100.64025940
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63988172
86Alcoholism_Homo sapiens_hsa050340.63638835
87Arginine and proline metabolism_Homo sapiens_hsa003300.63201495
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62890936
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.61200949
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60497053
91Regulation of autophagy_Homo sapiens_hsa041400.59866630
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59621841
93Lysosome_Homo sapiens_hsa041420.59206800
94Choline metabolism in cancer_Homo sapiens_hsa052310.57933960
95Bile secretion_Homo sapiens_hsa049760.55691831
96Rap1 signaling pathway_Homo sapiens_hsa040150.51363421
97Peroxisome_Homo sapiens_hsa041460.51221331
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51020342
99Insulin signaling pathway_Homo sapiens_hsa049100.49588690
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49086568
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48886704
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48607497
103Ras signaling pathway_Homo sapiens_hsa040140.48122893
104Linoleic acid metabolism_Homo sapiens_hsa005910.47912675
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.47197333
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45373490
107Fatty acid metabolism_Homo sapiens_hsa012120.45247729
108Tryptophan metabolism_Homo sapiens_hsa003800.43697920
109Ovarian steroidogenesis_Homo sapiens_hsa049130.43528188
110Wnt signaling pathway_Homo sapiens_hsa043100.42889494
111Inositol phosphate metabolism_Homo sapiens_hsa005620.42864846
112mTOR signaling pathway_Homo sapiens_hsa041500.42200428
113Renal cell carcinoma_Homo sapiens_hsa052110.40258936
114Endocytosis_Homo sapiens_hsa041440.39745821
115Hippo signaling pathway_Homo sapiens_hsa043900.39581075
116Endometrial cancer_Homo sapiens_hsa052130.38365340
117Oocyte meiosis_Homo sapiens_hsa041140.36501562
118Insulin resistance_Homo sapiens_hsa049310.35886749
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.34973066
120African trypanosomiasis_Homo sapiens_hsa051430.34578030
121Steroid biosynthesis_Homo sapiens_hsa001000.32994079
122Parkinsons disease_Homo sapiens_hsa050120.32939739
123Prolactin signaling pathway_Homo sapiens_hsa049170.32699891
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32391640
125Glycosaminoglycan degradation_Homo sapiens_hsa005310.32313136
126Hedgehog signaling pathway_Homo sapiens_hsa043400.30694150
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.28662030
128Non-small cell lung cancer_Homo sapiens_hsa052230.28434115
129Chemokine signaling pathway_Homo sapiens_hsa040620.27563552
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27541318
131Alzheimers disease_Homo sapiens_hsa050100.27375101

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