KCNN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.77375276
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.77375276
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.35150711
4positive regulation of gamma-delta T cell activation (GO:0046645)5.30341452
5ribosomal small subunit assembly (GO:0000028)5.26378426
6antigen processing and presentation of endogenous antigen (GO:0019883)4.94075264
7response to peptidoglycan (GO:0032494)4.65452564
8negative regulation of interleukin-12 production (GO:0032695)4.54978338
9viral transcription (GO:0019083)4.39349887
10regulation of vitamin D biosynthetic process (GO:0060556)4.35369045
11translational termination (GO:0006415)4.20308359
12regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.18323060
13lipopolysaccharide-mediated signaling pathway (GO:0031663)4.06180836
14regulation of gamma-delta T cell differentiation (GO:0045586)3.93360371
15antigen processing and presentation via MHC class Ib (GO:0002475)3.84182490
16regulation of T-helper 1 cell differentiation (GO:0045625)3.79367055
17positive regulation of B cell differentiation (GO:0045579)3.76360457
18DNA deamination (GO:0045006)3.74437947
19regulation of gamma-delta T cell activation (GO:0046643)3.70421416
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.67832853
21macrophage activation involved in immune response (GO:0002281)3.65170380
22T-helper 1 type immune response (GO:0042088)3.64999198
23translational elongation (GO:0006414)3.62064488
24regulation of podosome assembly (GO:0071801)3.57611439
25protein targeting to ER (GO:0045047)3.57202696
26cotranslational protein targeting to membrane (GO:0006613)3.56674750
27regulation of vitamin metabolic process (GO:0030656)3.54150927
28germinal center formation (GO:0002467)3.50142120
29cellular response to thyroid hormone stimulus (GO:0097067)3.49739641
30regulation of cytokine secretion involved in immune response (GO:0002739)3.49688406
31Arp2/3 complex-mediated actin nucleation (GO:0034314)3.47443348
32ribosomal small subunit biogenesis (GO:0042274)3.46657748
33negative regulation of erythrocyte differentiation (GO:0045647)3.43358712
34regulation of B cell receptor signaling pathway (GO:0050855)3.42405464
35positive regulation of chemokine biosynthetic process (GO:0045080)3.41928023
36negative regulation of myeloid cell apoptotic process (GO:0033033)3.41738195
37* positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.41492337
38establishment of protein localization to endoplasmic reticulum (GO:0072599)3.39057900
39protein localization to endoplasmic reticulum (GO:0070972)3.35798653
40immunoglobulin mediated immune response (GO:0016064)3.32472949
41viral life cycle (GO:0019058)3.27910078
42response to muramyl dipeptide (GO:0032495)3.25588365
43mast cell activation (GO:0045576)3.25040784
44positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.24839070
45nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.24625245
46regulation of B cell differentiation (GO:0045577)3.22873203
47negative regulation of nitric oxide biosynthetic process (GO:0045019)3.20344888
48regulation of interferon-alpha production (GO:0032647)3.20023557
49regulation of chemokine biosynthetic process (GO:0045073)3.19503002
50glycosphingolipid catabolic process (GO:0046479)3.18555967
51response to interferon-beta (GO:0035456)3.18363763
52telomere maintenance via semi-conservative replication (GO:0032201)3.18213503
53positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.16343381
54maturation of SSU-rRNA (GO:0030490)3.16073969
55leukocyte aggregation (GO:0070486)3.13119162
56regulation of interleukin-12 biosynthetic process (GO:0045075)3.12110041
57negative regulation of cytokine production involved in immune response (GO:0002719)3.10772784
58regulation of mononuclear cell migration (GO:0071675)3.10588016
59cellular protein complex disassembly (GO:0043624)3.10585861
60mature B cell differentiation involved in immune response (GO:0002313)3.09139523
61response to protozoan (GO:0001562)3.07173002
62defense response to protozoan (GO:0042832)3.05078306
63mature B cell differentiation (GO:0002335)3.03434545
64response to type I interferon (GO:0034340)3.01927636
65regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.01756979
66T cell homeostasis (GO:0043029)3.01667974
67regulation of antigen processing and presentation (GO:0002577)3.01283778
68myeloid dendritic cell activation (GO:0001773)3.00352088
69positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.00224861
70cellular response to type I interferon (GO:0071357)3.00035826
71type I interferon signaling pathway (GO:0060337)3.00035826
72translational initiation (GO:0006413)2.99122286
73dendritic cell differentiation (GO:0097028)2.97307755
74negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.96736196
75regulation of mast cell degranulation (GO:0043304)2.96286079
76amino sugar catabolic process (GO:0046348)2.95044092
77interferon-gamma production (GO:0032609)2.94528358
78negative regulation of cell killing (GO:0031342)2.93228091
79negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.93228091
80definitive hemopoiesis (GO:0060216)2.92896335
81negative T cell selection (GO:0043383)2.92794721
82negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.91271586
83oligosaccharide catabolic process (GO:0009313)2.91209997
84regulation of chronic inflammatory response (GO:0002676)2.90741019
85B cell mediated immunity (GO:0019724)2.89088254
86regulation of membrane protein ectodomain proteolysis (GO:0051043)2.88068185
87granulocyte activation (GO:0036230)2.87885320
88DNA strand elongation involved in DNA replication (GO:0006271)2.87736191
89negative thymic T cell selection (GO:0045060)2.87530972
90positive regulation of granulocyte differentiation (GO:0030854)2.86681527
91response to interleukin-15 (GO:0070672)2.84442655
92response to thyroid hormone (GO:0097066)2.83836274
93glycolipid catabolic process (GO:0019377)2.82870886
94regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.82148295
95telomere maintenance via recombination (GO:0000722)2.81374183
96protein localization to endosome (GO:0036010)2.81156468
97cellular response to interferon-beta (GO:0035458)2.80669407
98monocyte chemotaxis (GO:0002548)2.79034651
99DNA strand elongation (GO:0022616)2.78303965
100regulation of interferon-beta biosynthetic process (GO:0045357)2.77521463
101positive thymic T cell selection (GO:0045059)2.74788728
102erythrocyte maturation (GO:0043249)2.74777693
103cellular response to interferon-gamma (GO:0071346)2.74729729
104protein complex disassembly (GO:0043241)2.74696036
105Peyers patch development (GO:0048541)2.74581225
106mucosal-associated lymphoid tissue development (GO:0048537)2.74581225
107cellular response to lipopolysaccharide (GO:0071222)2.74265465
108positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.73470813
109positive regulation of heat generation (GO:0031652)2.73120707
110pinocytosis (GO:0006907)2.73113613
111NIK/NF-kappaB signaling (GO:0038061)2.70821014
112T cell migration (GO:0072678)2.70803544
113positive regulation of type 2 immune response (GO:0002830)2.70299390
114neutrophil activation involved in immune response (GO:0002283)2.69889176
115regulation of T-helper 2 cell differentiation (GO:0045628)2.69737689
116lymph node development (GO:0048535)2.69472457
117regulation of interleukin-2 biosynthetic process (GO:0045076)2.69434565
118modulation by symbiont of host cellular process (GO:0044068)2.69155640
119regulation of dendritic cell antigen processing and presentation (GO:0002604)2.68691336
120regulation of leukocyte degranulation (GO:0043300)2.68654523
121positive regulation of macrophage differentiation (GO:0045651)2.68543996
122positive regulation of isotype switching (GO:0045830)2.67064623
123regulation of mast cell activation involved in immune response (GO:0033006)2.66612645
124regulation of erythrocyte differentiation (GO:0045646)2.66611763
125activation of MAPKKK activity (GO:0000185)2.66510364
126myeloid cell activation involved in immune response (GO:0002275)2.66507641
127positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.64735880
128cellular response to molecule of bacterial origin (GO:0071219)2.64182008
129regulation of superoxide anion generation (GO:0032928)2.63938173
130CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.63351634
131regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.62982629
132positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.62773972
133positive regulation of antigen processing and presentation (GO:0002579)2.62772639
134cellular response to arsenic-containing substance (GO:0071243)2.62417603
135positive regulation of leukocyte degranulation (GO:0043302)2.62158625
136positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.62007330
137positive regulation of NF-kappaB import into nucleus (GO:0042346)2.60564669
138regulation of interleukin-12 production (GO:0032655)2.60259407
139B cell receptor signaling pathway (GO:0050853)2.60043467
140barbed-end actin filament capping (GO:0051016)2.59665541
141interferon-gamma-mediated signaling pathway (GO:0060333)2.59301528
142* regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.58681719
143myeloid dendritic cell differentiation (GO:0043011)2.58302191
144response to interferon-alpha (GO:0035455)2.57740738
145lymphocyte homeostasis (GO:0002260)2.57310110
146positive regulation of natural killer cell differentiation (GO:0032825)2.56974460
147regulation of cholesterol storage (GO:0010885)2.56844042
148negative regulation of phagocytosis (GO:0050765)2.56709259
149DNA replication initiation (GO:0006270)2.56464463
150regulation of type I interferon-mediated signaling pathway (GO:0060338)2.56394052
151detection of other organism (GO:0098543)2.56286836
152response to interferon-gamma (GO:0034341)2.54872312
153megakaryocyte development (GO:0035855)2.54628550
154macromolecular complex disassembly (GO:0032984)2.54462141
155* regulation of T cell receptor signaling pathway (GO:0050856)2.54425967
156actin nucleation (GO:0045010)2.53906537
157positive regulation by symbiont of host defense response (GO:0052509)2.53679241
158modulation by symbiont of host defense response (GO:0052031)2.53679241
159modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.53679241
160modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.53679241
161positive regulation by organism of defense response of other organism involved in symbiotic interact2.53679241
162modulation by symbiont of host immune response (GO:0052553)2.53679241
163positive regulation of interferon-alpha production (GO:0032727)2.53236353
164detection of bacterium (GO:0016045)2.53104436
165mitotic recombination (GO:0006312)2.49707183
166nuclear-transcribed mRNA catabolic process (GO:0000956)2.49419494
167ribosomal large subunit biogenesis (GO:0042273)2.48286321
168leukocyte homeostasis (GO:0001776)2.48121313
169deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.43385245

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.71886449
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.79190383
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.22255132
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.06558168
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.03176428
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.91631813
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.85077163
8SCL_19346495_ChIP-Seq_HPC-7_Human2.83851845
9SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.83338438
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.80838748
11MYC_22102868_ChIP-Seq_BL_Human2.67058631
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.65814779
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.51994885
14VDR_21846776_ChIP-Seq_THP-1_Human2.40534365
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.37800861
16* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.36911423
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.35146104
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.34342377
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.30681948
20TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.30273932
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.29088036
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.28532998
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.24564399
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.20036867
25SPI1_23547873_ChIP-Seq_NB4_Human2.13387457
26BP1_19119308_ChIP-ChIP_Hs578T_Human2.10554975
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.03413640
28MYB_26560356_Chip-Seq_TH2_Human2.02322480
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02183380
30E2F4_17652178_ChIP-ChIP_JURKAT_Human1.99203493
31MAF_26560356_Chip-Seq_TH1_Human1.98731271
32* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96156330
33LXR_22292898_ChIP-Seq_THP-1_Human1.94446541
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.93247711
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.91428526
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.87980576
37VDR_24763502_ChIP-Seq_THP-1_Human1.84321786
38SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.83563569
39MYB_26560356_Chip-Seq_TH1_Human1.80763587
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.80371293
41FOXM1_23109430_ChIP-Seq_U2OS_Human1.80220468
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79998258
43ERG_20887958_ChIP-Seq_HPC-7_Mouse1.75475704
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.75398548
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72574631
46VDR_23849224_ChIP-Seq_CD4+_Human1.71702534
47UTX_26944678_Chip-Seq_JUKART_Human1.69794991
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.68999711
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.68067695
50* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.67900781
51Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.67677442
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.67464295
53FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.63038183
54GATA1_22383799_ChIP-Seq_G1ME_Mouse1.62034697
55MYC_18358816_ChIP-ChIP_MESCs_Mouse1.61265663
56GATA1_22025678_ChIP-Seq_K562_Human1.61015711
57TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.59542419
58RUNX_20019798_ChIP-Seq_JUKART_Human1.59295385
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56256416
60EST1_17652178_ChIP-ChIP_JURKAT_Human1.56013928
61PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.55013845
62GABP_17652178_ChIP-ChIP_JURKAT_Human1.54387859
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49957744
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48251291
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.45944813
66MAF_26560356_Chip-Seq_TH2_Human1.45936872
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45703842
68JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.45558176
69ETS1_20019798_ChIP-Seq_JURKAT_Human1.44526497
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44474496
71* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.43908141
72* KDM2B_26808549_Chip-Seq_DND41_Human1.43057415
73FOXP3_21729870_ChIP-Seq_TREG_Human1.42628870
74MYC_19079543_ChIP-ChIP_MESCs_Mouse1.42070789
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.41081670
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.40845356
77MYC_19030024_ChIP-ChIP_MESCs_Mouse1.40393295
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38386795
79* TCF7_22412390_ChIP-Seq_EML_Mouse1.38086913
80TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36531392
81XRN2_22483619_ChIP-Seq_HELA_Human1.36360012
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35505360
83* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34815606
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33303662
85RACK7_27058665_Chip-Seq_MCF-7_Human1.31856619
86CIITA_25753668_ChIP-Seq_RAJI_Human1.30295488
87VDR_24787735_ChIP-Seq_THP-1_Human1.25131087
88ZNF263_19887448_ChIP-Seq_K562_Human1.24879778
89BCL6_27268052_Chip-Seq_Bcells_Human1.23765206
90SPI1_23127762_ChIP-Seq_K562_Human1.23101436
91ELF1_20517297_ChIP-Seq_JURKAT_Human1.22785262
92SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21738447
93BCOR_27268052_Chip-Seq_Bcells_Human1.21412152
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20931506
95KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.20467281
96DCP1A_22483619_ChIP-Seq_HELA_Human1.19976798
97* E2F1_21310950_ChIP-Seq_MCF-7_Human1.19739077
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17811528
99GATA1_19941826_ChIP-Seq_K562_Human1.16709880
100PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16601846
101PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16392035
102* GATA1_19941827_ChIP-Seq_MEL_Mouse1.16387253
103NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.16062148
104HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15713843
105ELK1_19687146_ChIP-ChIP_HELA_Human1.14823346
106* NCOR1_26117541_ChIP-Seq_K562_Human1.14135898
107CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13862944
108* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11911423
109CREB1_15753290_ChIP-ChIP_HEK293T_Human1.11808143
110NELFA_20434984_ChIP-Seq_ESCs_Mouse1.11597505
111NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11367237
112CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11272531
113SRF_21415370_ChIP-Seq_HL-1_Mouse1.10995911
114GABP_19822575_ChIP-Seq_HepG2_Human1.10879136
115PU_27001747_Chip-Seq_BMDM_Mouse1.10829399
116CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07157466
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07041964
118GATA3_27048872_Chip-Seq_THYMUS_Human1.06176873
119* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05710484
120ELK3_25401928_ChIP-Seq_HUVEC_Human1.04891494
121KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04704916
122SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04607896
123KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02727582
124CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02624904
125CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01865631
126E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01285104
127TTF2_22483619_ChIP-Seq_HELA_Human1.01050246
128TFEB_21752829_ChIP-Seq_HELA_Human1.00559750
129CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99634984
130KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95957845
131PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95107349
132ESR2_21235772_ChIP-Seq_MCF-7_Human0.94718655
133STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94415848
134STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94315752
135RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93426397
136HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.92721954

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.85677916
2MP0003763_abnormal_thymus_physiology3.18780998
3MP0002396_abnormal_hematopoietic_system3.14767677
4MP0000685_abnormal_immune_system3.13534185
5MP0005671_abnormal_response_to3.09478558
6MP0009785_altered_susceptibility_to2.92209007
7MP0003436_decreased_susceptibility_to2.82882993
8MP0009840_abnormal_foam_cell2.82872070
9MP0001800_abnormal_humoral_immune2.61659408
10MP0005025_abnormal_response_to2.60842761
11MP0005000_abnormal_immune_tolerance2.60716752
12MP0002398_abnormal_bone_marrow2.49753146
13MP0002452_abnormal_antigen_presenting2.48948782
14MP0002723_abnormal_immune_serum2.41650164
15MP0009333_abnormal_splenocyte_physiolog2.41420077
16* MP0002420_abnormal_adaptive_immunity2.40751565
17* MP0001819_abnormal_immune_cell2.39128128
18MP0002148_abnormal_hypersensitivity_rea2.38260955
19MP0001790_abnormal_immune_system2.37588950
20MP0005387_immune_system_phenotype2.37588950
21MP0005451_abnormal_body_composition2.31746396
22MP0000490_abnormal_crypts_of2.29367269
23MP0005464_abnormal_platelet_physiology2.29320524
24MP0002419_abnormal_innate_immunity2.24673017
25MP0003303_peritoneal_inflammation2.20240165
26MP0003806_abnormal_nucleotide_metabolis2.18524290
27MP0002166_altered_tumor_susceptibility2.15313896
28MP0003075_altered_response_to2.13481818
29* MP0000689_abnormal_spleen_morphology2.12560321
30MP0003724_increased_susceptibility_to2.12084955
31MP0000716_abnormal_immune_system2.11039989
32MP0004808_abnormal_hematopoietic_stem2.06811920
33* MP0005397_hematopoietic_system_phenotyp2.06737216
34* MP0001545_abnormal_hematopoietic_system2.06737216
35* MP0002722_abnormal_immune_system2.05385187
36MP0002405_respiratory_system_inflammati2.05367095
37MP0010155_abnormal_intestine_physiology2.05122629
38MP0002139_abnormal_hepatobiliary_system2.00360189
39MP0001873_stomach_inflammation1.97859649
40MP0003693_abnormal_embryo_hatching1.91624136
41* MP0002429_abnormal_blood_cell1.91129899
42MP0006082_CNS_inflammation1.87024559
43MP0001853_heart_inflammation1.85620139
44MP0005174_abnormal_tail_pigmentation1.83536922
45MP0003300_gastrointestinal_ulcer1.83513469
46MP0003453_abnormal_keratinocyte_physiol1.83260617
47MP0002006_tumorigenesis1.82836679
48MP0003866_abnormal_defecation1.78502348
49* MP0003656_abnormal_erythrocyte_physiolo1.78346101
50MP0000703_abnormal_thymus_morphology1.77661879
51MP0000604_amyloidosis1.76225276
52MP0004147_increased_porphyrin_level1.72317001
53MP0000465_gastrointestinal_hemorrhage1.69703106
54MP0001845_abnormal_inflammatory_respons1.63977935
55MP0004947_skin_inflammation1.56344058
56MP0000858_altered_metastatic_potential1.53993465
57MP0005075_abnormal_melanosome_morpholog1.53220109
58MP0009278_abnormal_bone_marrow1.49234121
59MP0010094_abnormal_chromosome_stability1.46220877
60MP0008057_abnormal_DNA_replication1.40456430
61MP0006054_spinal_hemorrhage1.38524941
62MP0002933_joint_inflammation1.33844661
63MP0003077_abnormal_cell_cycle1.32228799
64MP0002254_reproductive_system_inflammat1.31228985
65MP0008469_abnormal_protein_level1.29379169
66MP0008007_abnormal_cellular_replicative1.27464967
67MP0004510_myositis1.26167674
68MP0002019_abnormal_tumor_incidence1.25670140
69MP0003111_abnormal_nucleus_morphology1.25315641
70MP0002132_abnormal_respiratory_system1.25185005
71MP0002877_abnormal_melanocyte_morpholog1.24017674
72MP0001533_abnormal_skeleton_physiology1.23048417
73MP0008260_abnormal_autophagy1.18669308
74MP0005310_abnormal_salivary_gland1.16801745
75MP0005058_abnormal_lysosome_morphology1.14595772
76MP0004957_abnormal_blastocyst_morpholog1.13348415
77MP0002095_abnormal_skin_pigmentation1.10409276
78MP0003448_altered_tumor_morphology1.10245914
79MP0000015_abnormal_ear_pigmentation1.08857204
80MP0008058_abnormal_DNA_repair1.06928157
81MP0003172_abnormal_lysosome_physiology1.05153786
82MP0003091_abnormal_cell_migration1.04579906
83MP0008004_abnormal_stomach_pH1.03388902
84MP0005167_abnormal_blood-brain_barrier1.01742775
85MP0002332_abnormal_exercise_endurance1.01567570
86MP0005165_increased_susceptibility_to1.01157005
87MP0005164_abnormal_response_to1.00809810
88MP0010307_abnormal_tumor_latency0.98292350
89MP0000313_abnormal_cell_death0.96734444
90MP0009764_decreased_sensitivity_to0.92425673
91MP0003329_amyloid_beta_deposits0.92038499
92MP0000343_altered_response_to0.89471070
93MP0010352_gastrointestinal_tract_polyps0.85905954
94MP0003186_abnormal_redox_activity0.85071061
95* MP0001663_abnormal_digestive_system0.83894672
96MP0003690_abnormal_glial_cell0.82701597
97MP0001849_ear_inflammation0.81991282
98MP0009763_increased_sensitivity_to0.79333726
99MP0003183_abnormal_peptide_metabolism0.77480737
100MP0000477_abnormal_intestine_morphology0.76552438
101MP0008874_decreased_physiological_sensi0.74949905
102MP0004381_abnormal_hair_follicle0.74672190
103MP0002998_abnormal_bone_remodeling0.74251216
104MP0001881_abnormal_mammary_gland0.72784800
105MP0001542_abnormal_bone_strength0.72471686
106MP0009379_abnormal_foot_pigmentation0.72385056
107MP0005076_abnormal_cell_differentiation0.70864057
108MP0002138_abnormal_hepatobiliary_system0.70494208
109MP0000249_abnormal_blood_vessel0.68430391
110MP0001216_abnormal_epidermal_layer0.67807314
111MP0001851_eye_inflammation0.66660574
112MP0004858_abnormal_nervous_system0.64007470
113MP0003191_abnormal_cellular_cholesterol0.63898601
114MP0004883_abnormal_blood_vessel0.63517170
115MP0000350_abnormal_cell_proliferation0.61717858
116MP0003795_abnormal_bone_structure0.60943451
117MP0000920_abnormal_myelination0.60787074
118MP0000609_abnormal_liver_physiology0.60625785
119MP0005023_abnormal_wound_healing0.59629655
120MP0000372_irregular_coat_pigmentation0.59150305
121MP0009765_abnormal_xenobiotic_induced0.58346273
122MP0001986_abnormal_taste_sensitivity0.58022113
123MP0005647_abnormal_sex_gland0.55927281
124MP0003943_abnormal_hepatobiliary_system0.55618941
125MP0008873_increased_physiological_sensi0.55284015
126MP0003828_pulmonary_edema0.54557016
127MP0005166_decreased_susceptibility_to0.53345352
128MP0005390_skeleton_phenotype0.52561239
129MP0003279_aneurysm0.52104810
130MP0003566_abnormal_cell_adhesion0.51960135
131MP0009931_abnormal_skin_appearance0.51710676
132MP0000371_diluted_coat_color0.51413481

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)6.33271004
2Abnormality of liposaccharide metabolism (HP:0010968)6.33271004
3Abnormality of glycosphingolipid metabolism (HP:0004343)6.33271004
4Elevated erythrocyte sedimentation rate (HP:0003565)4.73233770
5Chronic otitis media (HP:0000389)4.68350947
6Abnormal number of erythroid precursors (HP:0012131)4.63987307
7Abnormality of cells of the erythroid lineage (HP:0012130)4.59787920
8Recurrent abscess formation (HP:0002722)4.41303610
9Dysostosis multiplex (HP:0000943)4.24122651
10Abnormality of the heme biosynthetic pathway (HP:0010472)4.23037434
11Loss of speech (HP:0002371)3.99155369
12Thrombocytosis (HP:0001894)3.95458596
13Eczematoid dermatitis (HP:0000976)3.95444361
14Petechiae (HP:0000967)3.93597254
15Myositis (HP:0100614)3.89095387
16IgM deficiency (HP:0002850)3.83063938
17Disinhibition (HP:0000734)3.71175389
18Recurrent viral infections (HP:0004429)3.70080101
19Recurrent fungal infections (HP:0002841)3.69479808
20Prolonged bleeding time (HP:0003010)3.61978469
21Recurrent bacterial skin infections (HP:0005406)3.58881376
22Systemic lupus erythematosus (HP:0002725)3.58823983
23Recurrent bronchitis (HP:0002837)3.54592483
24Pustule (HP:0200039)3.30371685
25Nasal polyposis (HP:0100582)3.29359271
26Reticulocytopenia (HP:0001896)3.26694885
27T lymphocytopenia (HP:0005403)3.25137338
28Aplastic anemia (HP:0001915)3.22233964
29Chronic mucocutaneous candidiasis (HP:0002728)3.20091995
30Recurrent cutaneous fungal infections (HP:0011370)3.20091995
31Pallor (HP:0000980)3.13255901
32Abnormality of T cells (HP:0002843)3.12777107
33Abnormality of the nasal mucosa (HP:0000433)3.12706948
34Axonal loss (HP:0003447)3.11665777
35Abnormality of T cell number (HP:0011839)3.11471808
36Abnormality of mucopolysaccharide metabolism (HP:0011020)3.07956478
37Abnormality of polysaccharide metabolism (HP:0011012)3.07956478
38Abnormality of glycosaminoglycan metabolism (HP:0004371)3.07956478
39Neurofibrillary tangles (HP:0002185)3.07873925
40Stomatitis (HP:0010280)3.03364505
41Panhypogammaglobulinemia (HP:0003139)3.03292786
42Mediastinal lymphadenopathy (HP:0100721)3.02509648
43Nuclear cataract (HP:0100018)3.01258379
44Epistaxis (HP:0000421)2.96397556
45Abnormality of macrophages (HP:0004311)2.93452596
46Mucopolysacchariduria (HP:0008155)2.91164547
47Urinary glycosaminoglycan excretion (HP:0003541)2.91164547
48Recurrent skin infections (HP:0001581)2.90722718
49Cellulitis (HP:0100658)2.89150230
50Autoimmune thrombocytopenia (HP:0001973)2.88322766
51Abnormality of T cell physiology (HP:0011840)2.86120036
52Meningitis (HP:0001287)2.84087476
53Abnormal delayed hypersensitivity skin test (HP:0002963)2.83207176
54Mutism (HP:0002300)2.73259351
55Impaired platelet aggregation (HP:0003540)2.67287678
56Abnormal platelet function (HP:0011869)2.67287678
57Vacuolated lymphocytes (HP:0001922)2.66318026
58IgG deficiency (HP:0004315)2.66061149
59Chronic obstructive pulmonary disease (HP:0006510)2.64737204
60Obstructive lung disease (HP:0006536)2.64737204
61Gastrointestinal stroma tumor (HP:0100723)2.63540091
62Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.62445381
63Hepatosplenomegaly (HP:0001433)2.58565756
64Gastrointestinal inflammation (HP:0004386)2.57480432
65Agammaglobulinemia (HP:0004432)2.56559554
66Amyloidosis (HP:0011034)2.55389123
67Inflammation of the large intestine (HP:0002037)2.55276034
68Microcytic anemia (HP:0001935)2.53628872
69Severe combined immunodeficiency (HP:0004430)2.50037366
70Abnormality of iron homeostasis (HP:0011031)2.49202892
71B lymphocytopenia (HP:0010976)2.48417895
72Abnormality of B cell number (HP:0010975)2.48417895
73Apathy (HP:0000741)2.47079516
74Upper motor neuron abnormality (HP:0002127)2.45858830
75Lymphoma (HP:0002665)2.45750237
76Vasculitis (HP:0002633)2.43373388
77Personality changes (HP:0000751)2.41772281
78Diminished motivation (HP:0000745)2.41734014
79Lymphopenia (HP:0001888)2.41515540
80Abnormality of the prostate (HP:0008775)2.40818023
81Pulmonary infiltrates (HP:0002113)2.40564483
82Orchitis (HP:0100796)2.39387930
83Reduced antithrombin III activity (HP:0001976)2.38686073
84Combined immunodeficiency (HP:0005387)2.37208656
85Abnormality of cells of the lymphoid lineage (HP:0012140)2.37116335
86Neuronal loss in central nervous system (HP:0002529)2.37032414
87Leukocytosis (HP:0001974)2.36896757
88Progressive neurologic deterioration (HP:0002344)2.36410343
89Interstitial pulmonary disease (HP:0006530)2.34949171
90Myocardial infarction (HP:0001658)2.34675022
91Thoracic kyphosis (HP:0002942)2.31529352
92Optic neuritis (HP:0100653)2.29950998
93Retrobulbar optic neuritis (HP:0100654)2.29950998
94Cerebral inclusion bodies (HP:0100314)2.29505843
95Basal ganglia calcification (HP:0002135)2.28163369
96Birth length less than 3rd percentile (HP:0003561)2.27750641
97Increased serum ferritin (HP:0003281)2.25738548
98Increased cerebral lipofuscin (HP:0011813)2.25609018
99Chronic sinusitis (HP:0011109)2.25458797
100Macrocytic anemia (HP:0001972)2.25223129
101Increased IgM level (HP:0003496)2.24310704
102Recurrent gram-negative bacterial infections (HP:0005420)2.23896850
103Vertebral compression fractures (HP:0002953)2.23108449
104Autoimmune hemolytic anemia (HP:0001890)2.23016926
105Prolonged neonatal jaundice (HP:0006579)2.22683224
106Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.21725686
107Hypertensive crisis (HP:0100735)2.19923058
108Poikiloderma (HP:0001029)2.18096192
109Increased neuronal autofluorescent lipopigment (HP:0002074)2.17374934
110Hypoplasia of the thymus (HP:0000778)2.15603648
111Spontaneous hematomas (HP:0007420)2.15091819
112Abnormality of the fingertips (HP:0001211)2.14820259
113Thyroiditis (HP:0100646)2.14445061
114Abnormality of reticulocytes (HP:0004312)2.13317574
115Granulocytopenia (HP:0001913)2.12921299
116Type I transferrin isoform profile (HP:0003642)2.11693442
117Glomerulonephritis (HP:0000099)2.10284830
118Abnormality of eosinophils (HP:0001879)2.09251577
119Hemoptysis (HP:0002105)2.08697566
120Restrictive lung disease (HP:0002091)2.07733543
121Metaphyseal irregularity (HP:0003025)2.07393554
122Gingival bleeding (HP:0000225)2.06037736
123Poikilocytosis (HP:0004447)2.05134244
124Encephalitis (HP:0002383)2.04819369
125Eosinophilia (HP:0001880)2.03903195
126Colitis (HP:0002583)2.01906323
127Abnormality of the vasculature of the conjunctiva (HP:0008054)2.00787940
128Abnormal platelet volume (HP:0011876)1.99276296
129Myelodysplasia (HP:0002863)1.98783216
130Amaurosis fugax (HP:0100576)1.97247293
131Urticaria (HP:0001025)1.97142174
132Hypergammaglobulinemia (HP:0010702)1.96169031
133Gingivitis (HP:0000230)1.95967768
134Agnosia (HP:0010524)1.95775428
135Skin ulcer (HP:0200042)1.94445239
136Osteomyelitis (HP:0002754)1.94293471
137Recurrent sinusitis (HP:0011108)1.94259686
138Abnormality of transition element cation homeostasis (HP:0011030)1.94256570
139Polyneuropathy (HP:0001271)1.93478314
140Keratoconjunctivitis sicca (HP:0001097)1.93464975
141Periodontitis (HP:0000704)1.93019576
142Increased IgE level (HP:0003212)1.91168644
143Purpura (HP:0000979)1.90867800
144Arthralgia (HP:0002829)1.90820883
145J-shaped sella turcica (HP:0002680)1.89249978
146Supranuclear gaze palsy (HP:0000605)1.88154599
147Dementia (HP:0000726)1.82999080
148Polygenic inheritance (HP:0010982)1.78635349
149Hematochezia (HP:0002573)1.78267757
150Bone pain (HP:0002653)1.77450675
151Inappropriate behavior (HP:0000719)1.75153699
152Pathologic fracture (HP:0002756)1.74425882
153Malnutrition (HP:0004395)1.71612352
154Splenomegaly (HP:0001744)1.70705639
155Nausea (HP:0002018)1.69820847
156Keratoconjunctivitis (HP:0001096)1.69132968

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.29895530
2KIT3.02638006
3TXK2.80655597
4JAK32.75695761
5PRPF4B2.62372410
6TBK12.45803568
7ZAP702.38564454
8PIM22.20739501
9IKBKE2.20601280
10EEF2K2.15575779
11TYK22.13221297
12DDR22.12252281
13GRK72.07851655
14BTK2.01547644
15IRAK41.98455770
16TEC1.98147450
17FLT31.86995418
18BLK1.84956306
19TESK11.77008727
20MAP3K141.74941366
21STK161.73884292
22SYK1.69899765
23IKBKB1.61163478
24RPS6KA41.60383697
25CSF1R1.56842347
26STK101.56288922
27FGR1.54453322
28MOS1.54397658
29MAP2K31.50553114
30NLK1.46370740
31TGFBR21.45726292
32PKN21.45154345
33EIF2AK11.41026355
34PIM11.39910532
35LCK1.39079597
36ABL21.34006705
37CDC42BPA1.32704339
38KDR1.31122873
39TLK11.30228201
40IRAK31.30169605
41BMPR21.27583182
42CLK11.26404068
43ACVR1B1.24603109
44TGFBR11.24369097
45LRRK21.24040624
46EPHA21.24031992
47MATK1.20487731
48LYN1.19005213
49GRK61.18292721
50SMG11.17401282
51ARAF1.16111349
52WEE11.15858802
53TAOK31.12036040
54RIPK11.10596936
55MAP3K101.10124194
56CDC71.10062419
57SCYL21.09753856
58ITK1.09679028
59HCK1.07723046
60MAP3K111.07622729
61MAP3K11.06170413
62FES1.01460713
63NEK20.98269212
64MST1R0.96038991
65FGFR40.95134593
66RIPK40.93212732
67PAK40.92636454
68ICK0.90982413
69ERN10.90304756
70JAK10.89344840
71CHUK0.88483965
72MST40.85701090
73LMTK20.85474861
74JAK20.84543360
75CSK0.84144310
76RPS6KB20.83388061
77STK40.83205422
78TRIB30.83072177
79IRAK20.81949571
80CDK190.81152585
81CDK40.80645458
82BMX0.80266432
83VRK10.76654804
84BUB10.75814370
85NEK90.75195874
86DYRK30.70056163
87SIK20.69900324
88MAP3K50.69818653
89* NME20.66732602
90TNK20.66248001
91MAP3K80.64760968
92VRK20.64189973
93EIF2AK30.64157203
94MAPK110.63641973
95TAOK20.62521000
96ATR0.61346206
97TNIK0.58827826
98HIPK20.58432700
99CDK70.58115336
100EPHB10.57540966
101TRPM70.56339420
102AURKB0.54980595
103MAP2K60.54451482
104LIMK10.54039465
105BCKDK0.51847123
106RPS6KA50.51050506
107TESK20.50308652
108MKNK10.50189467
109FGFR30.49753761
110MKNK20.49363473
111PRKG20.48721756
112SIK10.47974790
113CDK60.47011251
114BRSK20.46933945
115RPS6KC10.46843568
116RPS6KL10.46843568
117RPS6KA60.46271800
118DAPK30.45184472
119IRAK10.45080919
120MARK30.44423523
121DAPK10.43782539
122PDGFRA0.43284086
123MAP3K30.42367685
124TAOK10.41603458
125ADRBK20.41092783
126CDK80.40840968
127TTN0.40235651
128MAPKAPK20.39050634
129MUSK0.39005565
130MAP3K130.37876659
131SIK30.35343145
132PASK0.35258329
133PRKCD0.33979332
134MAPK40.33856447
135MAPKAPK50.33727554
136ABL10.32858342
137PDPK10.32123159
138PRKD20.30894596
139BRAF0.26443724
140PRKCQ0.26316870
141PAK10.26027156
142GSK3A0.23683012
143RPS6KA20.22790450
144PDK10.22494470

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.42724078
2Ribosome_Homo sapiens_hsa030103.40224968
3Primary immunodeficiency_Homo sapiens_hsa053403.04492758
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.36226250
5Leishmaniasis_Homo sapiens_hsa051402.22666907
6Mismatch repair_Homo sapiens_hsa034302.20158047
7Measles_Homo sapiens_hsa051622.17730888
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.09012722
9Base excision repair_Homo sapiens_hsa034102.05785156
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.96526930
11Type I diabetes mellitus_Homo sapiens_hsa049401.94754620
12Hematopoietic cell lineage_Homo sapiens_hsa046401.94744220
13Antigen processing and presentation_Homo sapiens_hsa046121.94236045
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.88549017
15Homologous recombination_Homo sapiens_hsa034401.74152127
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.73474596
17Herpes simplex infection_Homo sapiens_hsa051681.68625942
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.65376821
19B cell receptor signaling pathway_Homo sapiens_hsa046621.65349886
20Osteoclast differentiation_Homo sapiens_hsa043801.60342440
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.52464685
22Spliceosome_Homo sapiens_hsa030401.46418017
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.45045015
24Nucleotide excision repair_Homo sapiens_hsa034201.44999779
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.44749788
26T cell receptor signaling pathway_Homo sapiens_hsa046601.43846617
27Allograft rejection_Homo sapiens_hsa053301.43522277
28Legionellosis_Homo sapiens_hsa051341.42275720
29Pyrimidine metabolism_Homo sapiens_hsa002401.42096653
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35558282
31Acute myeloid leukemia_Homo sapiens_hsa052211.34332152
32Proteasome_Homo sapiens_hsa030501.33997481
33African trypanosomiasis_Homo sapiens_hsa051431.31839689
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.29121910
35Other glycan degradation_Homo sapiens_hsa005111.28864444
36Malaria_Homo sapiens_hsa051441.28335037
37Hepatitis B_Homo sapiens_hsa051611.26070740
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.24690332
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.24548009
40Influenza A_Homo sapiens_hsa051641.22419263
41Shigellosis_Homo sapiens_hsa051311.21164479
42Non-homologous end-joining_Homo sapiens_hsa034501.20267221
43Apoptosis_Homo sapiens_hsa042101.19267469
44Caffeine metabolism_Homo sapiens_hsa002321.19248129
45RNA polymerase_Homo sapiens_hsa030201.18853791
46Pertussis_Homo sapiens_hsa051331.17528463
47Bladder cancer_Homo sapiens_hsa052191.15880857
48Asthma_Homo sapiens_hsa053101.13915773
49Toxoplasmosis_Homo sapiens_hsa051451.12502568
50p53 signaling pathway_Homo sapiens_hsa041151.11922492
51Tuberculosis_Homo sapiens_hsa051521.10030488
52Cell cycle_Homo sapiens_hsa041101.09498533
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03010814
54Graft-versus-host disease_Homo sapiens_hsa053321.02780750
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01382533
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00123628
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97288348
58Fanconi anemia pathway_Homo sapiens_hsa034600.96971215
59Epstein-Barr virus infection_Homo sapiens_hsa051690.95927402
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94579697
61Sulfur relay system_Homo sapiens_hsa041220.93404923
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93320051
63Chronic myeloid leukemia_Homo sapiens_hsa052200.93189722
64One carbon pool by folate_Homo sapiens_hsa006700.92929725
65TNF signaling pathway_Homo sapiens_hsa046680.91879714
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90457465
67Viral carcinogenesis_Homo sapiens_hsa052030.89236820
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88064993
69Prion diseases_Homo sapiens_hsa050200.87661072
70Platelet activation_Homo sapiens_hsa046110.84538705
71Salmonella infection_Homo sapiens_hsa051320.84192378
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.83329944
73N-Glycan biosynthesis_Homo sapiens_hsa005100.82918938
74Viral myocarditis_Homo sapiens_hsa054160.81005867
75RNA degradation_Homo sapiens_hsa030180.80432892
76HTLV-I infection_Homo sapiens_hsa051660.80248057
77Systemic lupus erythematosus_Homo sapiens_hsa053220.78655622
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78170834
79RNA transport_Homo sapiens_hsa030130.77236704
80Protein export_Homo sapiens_hsa030600.75787755
81Chemokine signaling pathway_Homo sapiens_hsa040620.73039710
82VEGF signaling pathway_Homo sapiens_hsa043700.72673015
83Pancreatic cancer_Homo sapiens_hsa052120.72546162
84Small cell lung cancer_Homo sapiens_hsa052220.72131229
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71164406
86Pentose phosphate pathway_Homo sapiens_hsa000300.71160368
87Staphylococcus aureus infection_Homo sapiens_hsa051500.69914819
88Hepatitis C_Homo sapiens_hsa051600.69575525
89Thyroid cancer_Homo sapiens_hsa052160.68391902
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.67945772
91Amoebiasis_Homo sapiens_hsa051460.67748273
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64941987
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.63370283
94Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62425516
95Galactose metabolism_Homo sapiens_hsa000520.61042912
96Lysosome_Homo sapiens_hsa041420.57522383
97Autoimmune thyroid disease_Homo sapiens_hsa053200.57311163
98Collecting duct acid secretion_Homo sapiens_hsa049660.55279321
99Prolactin signaling pathway_Homo sapiens_hsa049170.54348470
100Sphingolipid metabolism_Homo sapiens_hsa006000.54131009
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53825786
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53555817
103Purine metabolism_Homo sapiens_hsa002300.53288686
104Non-small cell lung cancer_Homo sapiens_hsa052230.53128745
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.53015001
106Folate biosynthesis_Homo sapiens_hsa007900.52605996
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.52427011
108Rheumatoid arthritis_Homo sapiens_hsa053230.51239591
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50361028
110Fructose and mannose metabolism_Homo sapiens_hsa000510.50093419
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50060487
112Basal transcription factors_Homo sapiens_hsa030220.47469419
113Colorectal cancer_Homo sapiens_hsa052100.46103322
114Vibrio cholerae infection_Homo sapiens_hsa051100.42759059
115Endocytosis_Homo sapiens_hsa041440.42491232
116Phagosome_Homo sapiens_hsa041450.38580243
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38351565
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37108935
119Notch signaling pathway_Homo sapiens_hsa043300.36438735
120Sulfur metabolism_Homo sapiens_hsa009200.36021724
121HIF-1 signaling pathway_Homo sapiens_hsa040660.30197681
122Mineral absorption_Homo sapiens_hsa049780.28187807
123Glutathione metabolism_Homo sapiens_hsa004800.23740519
124Insulin resistance_Homo sapiens_hsa049310.20578852
125Complement and coagulation cascades_Homo sapiens_hsa046100.18127284
126Renal cell carcinoma_Homo sapiens_hsa052110.15138126
127Proteoglycans in cancer_Homo sapiens_hsa052050.14041670
128MAPK signaling pathway_Homo sapiens_hsa040100.13539704
129mTOR signaling pathway_Homo sapiens_hsa041500.11210975
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.10641520

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