KCNQ4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane repair (GO:0001778)5.35202313
2peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.68110803
3creatine metabolic process (GO:0006600)4.65504052
4skeletal muscle fiber development (GO:0048741)4.52919919
5actin-myosin filament sliding (GO:0033275)4.51232271
6muscle filament sliding (GO:0030049)4.51232271
7sarcoplasmic reticulum calcium ion transport (GO:0070296)4.31500626
8skeletal muscle contraction (GO:0003009)4.28433385
9regulation of synapse structural plasticity (GO:0051823)4.15386573
10regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.88773403
11regulation of skeletal muscle contraction (GO:0014819)3.88564863
12actin-mediated cell contraction (GO:0070252)3.86687839
13myotube cell development (GO:0014904)3.81315798
14positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.78109489
15neuronal action potential propagation (GO:0019227)3.71996191
16regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.63902067
17regulation of translational fidelity (GO:0006450)3.63110352
18negative regulation of potassium ion transmembrane transport (GO:1901380)3.59523435
19regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.45491815
20cell migration in hindbrain (GO:0021535)3.38035152
21negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.35888088
22regulation of membrane repolarization (GO:0060306)3.33194786
23synaptic vesicle maturation (GO:0016188)3.30247416
24vocalization behavior (GO:0071625)3.30021313
25myotube differentiation (GO:0014902)3.29669590
26oxidative phosphorylation (GO:0006119)3.28177020
27regulation of cell communication by electrical coupling (GO:0010649)3.27372402
28cardiac myofibril assembly (GO:0055003)3.26762276
29neuromuscular synaptic transmission (GO:0007274)3.22209771
30striated muscle atrophy (GO:0014891)3.20846966
31synaptic vesicle docking involved in exocytosis (GO:0016081)3.16935089
32synaptic vesicle exocytosis (GO:0016079)3.16852547
33cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.15794925
34proline biosynthetic process (GO:0006561)3.11720714
35positive regulation of fatty acid oxidation (GO:0046321)3.10558210
36regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.09965794
37activation of protein kinase A activity (GO:0034199)3.08970218
38DNA unwinding involved in DNA replication (GO:0006268)3.08718172
39NADH metabolic process (GO:0006734)3.08105172
40regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.05715742
41postsynaptic membrane organization (GO:0001941)3.04619810
42cell communication by electrical coupling (GO:0010644)3.03379282
43muscle fiber development (GO:0048747)3.02873046
44positive regulation of glycogen biosynthetic process (GO:0045725)3.02774624
45regulation of calcium ion transmembrane transporter activity (GO:1901019)3.02719694
46regulation of calcium ion transmembrane transport (GO:1903169)3.02719694
47striated muscle contraction (GO:0006941)3.01788945
48mitotic chromosome condensation (GO:0007076)3.00741546
49regulation of NFAT protein import into nucleus (GO:0051532)3.00550690
50alanine transport (GO:0032328)3.00119110
51neuron cell-cell adhesion (GO:0007158)2.99797573
52peptidyl-arginine omega-N-methylation (GO:0035247)2.99668651
53positive regulation of synapse maturation (GO:0090129)2.99269577
54adherens junction assembly (GO:0034333)2.97394982
55calcium-mediated signaling using intracellular calcium source (GO:0035584)2.97137629
56regulation of short-term neuronal synaptic plasticity (GO:0048172)2.96776880
57actin filament-based movement (GO:0030048)2.96474365
58muscle cell fate commitment (GO:0042693)2.94774341
59sarcomere organization (GO:0045214)2.94042606
60muscle cell cellular homeostasis (GO:0046716)2.93842272
61myoblast fusion (GO:0007520)2.92401565
62membrane depolarization during action potential (GO:0086010)2.92352501
63cell-substrate adherens junction assembly (GO:0007045)2.91912167
64focal adhesion assembly (GO:0048041)2.91912167
65oxaloacetate metabolic process (GO:0006107)2.90462066
66positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.88946589
67response to parathyroid hormone (GO:0071107)2.88323048
68protein heterotrimerization (GO:0070208)2.87146900
69gluconeogenesis (GO:0006094)2.86987235
70positive regulation of myotube differentiation (GO:0010831)2.85060989
71response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.83296396
72muscle atrophy (GO:0014889)2.82992861
73cytoskeletal anchoring at plasma membrane (GO:0007016)2.80658017
74axonal fasciculation (GO:0007413)2.79694683
75cell communication involved in cardiac conduction (GO:0086065)2.79034322
76striated muscle adaptation (GO:0014888)2.76774812
77response to inactivity (GO:0014854)2.76299779
78membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.76294378
79neuronal action potential (GO:0019228)2.76241926
80proline transport (GO:0015824)2.75892571
81neurofilament cytoskeleton organization (GO:0060052)2.75536317
82positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.75315143
83skeletal muscle adaptation (GO:0043501)2.75164840
84dendrite morphogenesis (GO:0048813)2.73824339
85actomyosin structure organization (GO:0031032)2.73661245
86formation of translation preinitiation complex (GO:0001731)2.72774009
87positive regulation of potassium ion transmembrane transport (GO:1901381)2.72093964
88positive regulation of glycogen metabolic process (GO:0070875)2.70707561
89negative regulation of cell size (GO:0045792)2.69729611
90axon extension (GO:0048675)2.66805692
91sodium ion export (GO:0071436)2.65808147
92muscle contraction (GO:0006936)2.64895979
93locomotory exploration behavior (GO:0035641)2.64325129
94regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.64080380
95cochlea morphogenesis (GO:0090103)2.63643656
96muscle organ morphogenesis (GO:0048644)2.63193974
97regulation of skeletal muscle cell differentiation (GO:2001014)2.62572575
98layer formation in cerebral cortex (GO:0021819)2.61713210
99intracellular estrogen receptor signaling pathway (GO:0030520)2.60884419
100hexose biosynthetic process (GO:0019319)2.60810788
101positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.58712166
102dermatan sulfate biosynthetic process (GO:0030208)2.57067951
103lymph vessel development (GO:0001945)2.56996816
104positive regulation of potassium ion transport (GO:0043268)2.53505017
105tricarboxylic acid cycle (GO:0006099)2.53135858
106neuron recognition (GO:0008038)2.52793386
107outer ear morphogenesis (GO:0042473)2.52459264
108syncytium formation by plasma membrane fusion (GO:0000768)2.51319191
109membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.50653459
110myofibril assembly (GO:0030239)2.50513805
111positive regulation of myoblast differentiation (GO:0045663)2.49894362
112positive regulation of axon extension (GO:0045773)2.49744936
113regulation of relaxation of muscle (GO:1901077)2.48029947
114response to muscle activity (GO:0014850)2.47989479
115peptidyl-arginine methylation (GO:0018216)2.47952314
116peptidyl-arginine N-methylation (GO:0035246)2.47952314
117regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.47864279
118cellular protein complex localization (GO:0034629)2.47509328
119embryonic viscerocranium morphogenesis (GO:0048703)2.45322699
120neuromuscular junction development (GO:0007528)2.44591640
121positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.44528466
122regulation of glutamate receptor signaling pathway (GO:1900449)2.44369153
123skeletal muscle tissue development (GO:0007519)2.43827673
124regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.43824669
125regulation of axon extension involved in axon guidance (GO:0048841)2.43278043
126positive regulation of skeletal muscle tissue development (GO:0048643)2.42869538
127regulation of synaptic vesicle exocytosis (GO:2000300)2.42277808
128muscle organ development (GO:0007517)2.41879056
129myelination in peripheral nervous system (GO:0022011)2.41757023
130peripheral nervous system axon ensheathment (GO:0032292)2.41757023
131regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.41065518
132histone arginine methylation (GO:0034969)2.40734271
133mitochondrial genome maintenance (GO:0000002)2.39805754
134positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.39765336
135glutamate secretion (GO:0014047)2.38617748
136regulation of potassium ion transmembrane transport (GO:1901379)2.38313977
137coronary vasculature morphogenesis (GO:0060977)2.37573569
138regulation of myotube differentiation (GO:0010830)2.37495879
139cardiac muscle contraction (GO:0060048)2.37403612
140regulation of cellular respiration (GO:0043457)2.37342169
141muscle system process (GO:0003012)2.36371995
142muscle structure development (GO:0061061)2.36278761
143negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.36043864
144negative regulation of calcium ion transmembrane transport (GO:1903170)2.36043864
145apoptotic process involved in morphogenesis (GO:0060561)2.34134727
146innervation (GO:0060384)2.33997916
147negative regulation of microtubule polymerization (GO:0031115)2.33464435
148retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.32322157
149negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.32249758
150potassium ion import (GO:0010107)2.31885688
151regulation of potassium ion transmembrane transporter activity (GO:1901016)2.31722738
152DNA synthesis involved in DNA repair (GO:0000731)2.31655750
153monosaccharide biosynthetic process (GO:0046364)2.30760841
154protein complex localization (GO:0031503)2.30191885
155cardiac muscle hypertrophy (GO:0003300)2.29981739
156mitotic sister chromatid segregation (GO:0000070)2.29640341
157negative regulation of potassium ion transport (GO:0043267)2.29373299
158DNA replication initiation (GO:0006270)2.28473991
159cerebellar granule cell differentiation (GO:0021707)2.27157498

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.54165757
2* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01365039
3E2F7_22180533_ChIP-Seq_HELA_Human2.87422715
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.85350449
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.85030260
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.69886424
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65022292
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65022292
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.64312448
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.54208241
11LXR_22292898_ChIP-Seq_THP-1_Human2.49112025
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48378329
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42607509
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40012895
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36073992
16TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.35453001
17* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32684257
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.27573223
19MYC_22102868_ChIP-Seq_BL_Human2.26933878
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.22942975
21GBX2_23144817_ChIP-Seq_PC3_Human2.19252473
22AR_21572438_ChIP-Seq_LNCaP_Human2.15232426
23* EZH2_27294783_Chip-Seq_ESCs_Mouse2.13307746
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.11805466
25FOXM1_23109430_ChIP-Seq_U2OS_Human2.08493557
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.02012667
27* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.01360065
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.97112872
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96546309
30* RNF2_27304074_Chip-Seq_ESCs_Mouse1.95586247
31DROSHA_22980978_ChIP-Seq_HELA_Human1.94233587
32MYC_18555785_ChIP-Seq_MESCs_Mouse1.91358113
33* RACK7_27058665_Chip-Seq_MCF-7_Human1.90582215
34XRN2_22483619_ChIP-Seq_HELA_Human1.89997180
35TET1_21451524_ChIP-Seq_MESCs_Mouse1.84777181
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84665112
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.79603908
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.75208707
39* VDR_21846776_ChIP-Seq_THP-1_Human1.75178296
40CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.75115285
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.74849127
42CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.68599161
43* P68_20966046_ChIP-Seq_HELA_Human1.68242407
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.68153653
45KDM2B_26808549_Chip-Seq_DND41_Human1.67592183
46MYC_18358816_ChIP-ChIP_MESCs_Mouse1.65330919
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63492201
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.62497614
49REST_21632747_ChIP-Seq_MESCs_Mouse1.58907674
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.56928820
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54750710
52SRY_22984422_ChIP-ChIP_TESTIS_Rat1.50533974
53* CREB1_26743006_Chip-Seq_LNCaP_Human1.50039480
54* SA1_27219007_Chip-Seq_ERYTHROID_Human1.48948260
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.48443621
56EP300_21415370_ChIP-Seq_HL-1_Mouse1.48213289
57EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47915543
58CTCF_27219007_Chip-Seq_ERYTHROID_Human1.46699076
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46564457
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46136135
61NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.44194551
62SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.44009368
63RARG_19884340_ChIP-ChIP_MEFs_Mouse1.43847994
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43610313
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43348511
66RARB_27405468_Chip-Seq_BRAIN_Mouse1.43251767
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42558833
68CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.42230528
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.42000572
70SMC4_20622854_ChIP-Seq_HELA_Human1.39835989
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39604685
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38634386
73* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.38032337
74TCF7_22412390_ChIP-Seq_EML_Mouse1.36762216
75* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.36465522
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35989899
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.35548227
78ZNF263_19887448_ChIP-Seq_K562_Human1.34577903
79MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33360461
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32075270
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30645277
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.30259758
83STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29069628
84RING1B_27294783_Chip-Seq_ESCs_Mouse1.28789696
85MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.27414195
86AHR_22903824_ChIP-Seq_MCF-7_Human1.27409674
87SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26704455
88CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26190285
89NCOR1_26117541_ChIP-Seq_K562_Human1.25879482
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25573396
91* SOX2_21211035_ChIP-Seq_LN229_Gbm1.25568281
92DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25545828
93SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.25118036
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25097419
95PIAS1_25552417_ChIP-Seq_VCAP_Human1.24921827
96* KDM2B_26808549_Chip-Seq_K562_Human1.24288764
97TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23359830
98WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22364579
99ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21726699
100ZNF274_21170338_ChIP-Seq_K562_Hela1.21008915
101CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20083457
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19952433
103ELF1_20517297_ChIP-Seq_JURKAT_Human1.19742067
104ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18758409
105SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.18700370
106NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17822820
107MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17600964
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16017680
109SMAD4_21799915_ChIP-Seq_A2780_Human1.15661247
110TP53_20018659_ChIP-ChIP_R1E_Mouse1.15636108
111EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14740026
112ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14562249
113* SA1_27219007_Chip-Seq_Bcells_Human1.13744395
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13416330
115ARNT_22903824_ChIP-Seq_MCF-7_Human1.12791214
116TP53_18474530_ChIP-ChIP_U2OS_Human1.12749334
117SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12460072
118P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10691230
119TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10374368
120TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10005776
121CBX2_27304074_Chip-Seq_ESCs_Mouse1.09756489
122AR_19668381_ChIP-Seq_PC3_Human1.09092880
123CTCF_21964334_Chip-Seq_Bcells_Human1.07642135
124BCAT_22108803_ChIP-Seq_LS180_Human1.07219794
125POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04659933
126STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.04035189
127KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03816204
128AR_25329375_ChIP-Seq_VCAP_Human1.03736241
129SMAD3_21741376_ChIP-Seq_EPCs_Human1.03503499
130KDM2B_26808549_Chip-Seq_JURKAT_Human1.03364590
131SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02993869
132OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01847220
133TBX5_21415370_ChIP-Seq_HL-1_Mouse1.01394882
134* CTCF_27219007_Chip-Seq_Bcells_Human1.01069610
135CTCF_21964334_ChIP-Seq_BJAB-B_Human1.00829375
136JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.99798130
137TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99624070
138CTCF_26484167_Chip-Seq_Bcells_Mouse0.99583926
139CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.99333468
140RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99130020
141ESR1_21235772_ChIP-Seq_MCF-7_Human0.98918350
142FOXP1_21924763_ChIP-Seq_HESCs_Human0.98888957
143YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98065677
144* RING1B_27294783_Chip-Seq_NPCs_Mouse0.98050032
145* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97815413
146CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97207077
147NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96615597
148RARA_24833708_ChIP-Seq_LIVER_Mouse0.95809833
149CJUN_26792858_Chip-Seq_BT549_Human0.95593217
150NELFA_20434984_ChIP-Seq_ESCs_Mouse0.95372648
151ETS1_21867929_ChIP-Seq_TH2_Mouse0.95064133
152WT1_19549856_ChIP-ChIP_CCG9911_Human0.94724931
153BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93807144
154IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93039828
155OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91481979
156PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.90502821
157NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90334116
158* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88563266
159THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88404426
160P300_19829295_ChIP-Seq_ESCs_Human0.88207531
161SMAD4_21741376_ChIP-Seq_HESCs_Human0.88147784
162STAT3_23295773_ChIP-Seq_U87_Human0.86603835
163SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85803877
164CLOCK_20551151_ChIP-Seq_293T_Human0.85664472
165TBX20_22328084_ChIP-Seq_HEART_Mouse0.84992362
166TBX20_22080862_ChIP-Seq_HEART_Mouse0.84992362
167AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84958273
168TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84040776
169GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.83490526
170ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82605808
171CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82035852
172TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81548031
173* TET1_21490601_ChIP-Seq_MESCs_Mouse0.81440984

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy4.40519979
2MP0004145_abnormal_muscle_electrophysio3.95740486
3MP0004270_analgesia3.62164619
4MP0000749_muscle_degeneration3.49915070
5MP0002837_dystrophic_cardiac_calcinosis3.17907164
6MP0000678_abnormal_parathyroid_gland3.09854219
7MP0003646_muscle_fatigue3.01681603
8MP0004859_abnormal_synaptic_plasticity2.75892584
9MP0000747_muscle_weakness2.59132935
10MP0003705_abnormal_hypodermis_morpholog2.43005880
11MP0000750_abnormal_muscle_regeneration2.42114321
12MP0004858_abnormal_nervous_system2.38787561
13MP0008438_abnormal_cutaneous_collagen2.30572442
14MP0002106_abnormal_muscle_physiology2.20808770
15MP0005503_abnormal_tendon_morphology2.19291000
16MP0000759_abnormal_skeletal_muscle2.18626844
17MP0002735_abnormal_chemical_nociception2.15492823
18MP0004087_abnormal_muscle_fiber2.09485323
19MP0004036_abnormal_muscle_relaxation2.08918995
20MP0002734_abnormal_mechanical_nocicepti2.07889381
21MP0009780_abnormal_chondrocyte_physiolo2.04811083
22MP0005369_muscle_phenotype2.04548981
23MP0005451_abnormal_body_composition2.00493188
24MP0004233_abnormal_muscle_weight1.97165354
25MP0003635_abnormal_synaptic_transmissio1.94935121
26MP0002108_abnormal_muscle_morphology1.92876318
27MP0001346_abnormal_lacrimal_gland1.88381994
28MP0000733_abnormal_muscle_development1.84014094
29MP0005620_abnormal_muscle_contractility1.82879585
30MP0004215_abnormal_myocardial_fiber1.76160848
31MP0006276_abnormal_autonomic_nervous1.70016806
32MP0005275_abnormal_skin_tensile1.66170439
33MP0002269_muscular_atrophy1.63457936
34MP0001299_abnormal_eye_distance/1.61886222
35MP0001968_abnormal_touch/_nociception1.60690947
36MP0009046_muscle_twitch1.58392117
37MP0004130_abnormal_muscle_cell1.58384215
38MP0003123_paternal_imprinting1.52547777
39MP0002733_abnormal_thermal_nociception1.49378100
40MP0002184_abnormal_innervation1.47065979
41MP0003111_abnormal_nucleus_morphology1.45730914
42MP0002063_abnormal_learning/memory/cond1.42578263
43MP0002736_abnormal_nociception_after1.40127892
44MP0000013_abnormal_adipose_tissue1.39066888
45MP0002822_catalepsy1.33039139
46MP0003880_abnormal_central_pattern1.32257264
47MP0008569_lethality_at_weaning1.31740943
48MP0002272_abnormal_nervous_system1.28662963
49MP0002909_abnormal_adrenal_gland1.27988328
50MP0009745_abnormal_behavioral_response1.27177111
51MP0002972_abnormal_cardiac_muscle1.27037375
52MP0001970_abnormal_pain_threshold1.26682483
53MP0002067_abnormal_sensory_capabilities1.25287459
54MP0004484_altered_response_of1.25122735
55MP0002064_seizures1.24253783
56MP0000003_abnormal_adipose_tissue1.22870476
57MP0006036_abnormal_mitochondrial_physio1.22667785
58MP0004084_abnormal_cardiac_muscle1.22141110
59MP0000566_synostosis1.21911955
60MP0004957_abnormal_blastocyst_morpholog1.19266014
61MP0005076_abnormal_cell_differentiation1.19035044
62MP0003137_abnormal_impulse_conducting1.17380360
63MP0000462_abnormal_digestive_system1.17230828
64MP0009672_abnormal_birth_weight1.16958220
65MP0005623_abnormal_meninges_morphology1.16852956
66MP0003122_maternal_imprinting1.14271091
67MP0003693_abnormal_embryo_hatching1.13845512
68MP0005423_abnormal_somatic_nervous1.12366080
69MP0002572_abnormal_emotion/affect_behav1.11175054
70MP0000955_abnormal_spinal_cord1.11067461
71MP0001440_abnormal_grooming_behavior1.10997074
72MP0001486_abnormal_startle_reflex1.09982976
73MP0005330_cardiomyopathy1.09619208
74MP0008932_abnormal_embryonic_tissue1.08855885
75MP0003283_abnormal_digestive_organ1.08170849
76MP0004885_abnormal_endolymph1.05855867
77MP0004185_abnormal_adipocyte_glucose1.04839754
78MP0000778_abnormal_nervous_system1.04833862
79MP0000049_abnormal_middle_ear1.02635309
80MP0005375_adipose_tissue_phenotype1.02264864
81MP0001730_embryonic_growth_arrest1.01580195
82MP0003329_amyloid_beta_deposits1.01439189
83MP0004085_abnormal_heartbeat1.01175377
84MP0003938_abnormal_ear_development0.98571900
85MP0004272_abnormal_basement_membrane0.98147744
86MP0009250_abnormal_appendicular_skeleto0.97586798
87MP0005645_abnormal_hypothalamus_physiol0.93981402
88MP0000534_abnormal_ureter_morphology0.93613981
89MP0001501_abnormal_sleep_pattern0.93183237
90MP0000537_abnormal_urethra_morphology0.92787951
91MP0005670_abnormal_white_adipose0.92485420
92MP0004811_abnormal_neuron_physiology0.92353718
93* MP0003879_abnormal_hair_cell0.89165043
94MP0002971_abnormal_brown_adipose0.87942239
95MP0005666_abnormal_adipose_tissue0.87928868
96MP0002234_abnormal_pharynx_morphology0.84461527
97MP0001661_extended_life_span0.84226529
98MP0010094_abnormal_chromosome_stability0.84112794
99MP0003077_abnormal_cell_cycle0.84049704
100MP0002066_abnormal_motor_capabilities/c0.83151702
101MP0006138_congestive_heart_failure0.80415360
102MP0001544_abnormal_cardiovascular_syste0.80166550
103MP0005385_cardiovascular_system_phenoty0.80166550
104* MP0002882_abnormal_neuron_morphology0.79908465
105MP0004510_myositis0.79399149
106MP0002114_abnormal_axial_skeleton0.77299119
107MP0002751_abnormal_autonomic_nervous0.74025250
108MP0000350_abnormal_cell_proliferation0.73304751
109MP0002127_abnormal_cardiovascular_syste0.73209415
110MP0004924_abnormal_behavior0.72536466
111MP0005386_behavior/neurological_phenoty0.72536466
112MP0005187_abnormal_penis_morphology0.72370820
113MP0004147_increased_porphyrin_level0.72333827
114MP0002080_prenatal_lethality0.71439756
115MP0001502_abnormal_circadian_rhythm0.71340383
116MP0010630_abnormal_cardiac_muscle0.69125299
117MP0003942_abnormal_urinary_system0.69122437
118MP0002249_abnormal_larynx_morphology0.69005349
119MP0000762_abnormal_tongue_morphology0.68942794
120MP0001348_abnormal_lacrimal_gland0.68630878
121MP0000266_abnormal_heart_morphology0.67890792
122MP0002557_abnormal_social/conspecific_i0.67351451
123MP0003984_embryonic_growth_retardation0.67321359
124MP0002085_abnormal_embryonic_tissue0.65308744
125MP0001485_abnormal_pinna_reflex0.64778940
126MP0002332_abnormal_exercise_endurance0.64774505
127MP0008961_abnormal_basal_metabolism0.63672714
128MP0005380_embryogenesis_phenotype0.63480265
129MP0001672_abnormal_embryogenesis/_devel0.63480265
130MP0008995_early_reproductive_senescence0.62397380
131MP0003279_aneurysm0.61511427
132MP0003634_abnormal_glial_cell0.61336010
133MP0002088_abnormal_embryonic_growth/wei0.60676021
134MP0001697_abnormal_embryo_size0.60083790
135MP0008775_abnormal_heart_ventricle0.60007775
136MP0000428_abnormal_craniofacial_morphol0.59656052
137MP0010030_abnormal_orbit_morphology0.58775245
138MP0001943_abnormal_respiration0.58051290
139MP0005508_abnormal_skeleton_morphology0.57853468

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)6.18230877
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.17796001
3Nemaline bodies (HP:0003798)5.66997610
4Type 1 muscle fiber predominance (HP:0003803)5.48949423
5Distal arthrogryposis (HP:0005684)5.26481987
6Exercise-induced myalgia (HP:0003738)4.46368298
7Fetal akinesia sequence (HP:0001989)4.36955347
8Calf muscle hypertrophy (HP:0008981)4.35374761
9Muscle hypertrophy of the lower extremities (HP:0008968)4.31003848
10Difficulty running (HP:0009046)4.23716197
11Muscle fiber splitting (HP:0003555)4.09711987
12Round ear (HP:0100830)4.05901857
13Hyporeflexia of lower limbs (HP:0002600)3.91918405
14Abnormality of the calf musculature (HP:0001430)3.81078578
15Abnormality of the calcaneus (HP:0008364)3.80320311
16Centrally nucleated skeletal muscle fibers (HP:0003687)3.56518528
17Ulnar deviation of the wrist (HP:0003049)3.47385739
18Myotonia (HP:0002486)3.46245786
19Exercise-induced muscle cramps (HP:0003710)3.46154630
20Absent phalangeal crease (HP:0006109)3.41150227
21EMG: myopathic abnormalities (HP:0003458)3.41070327
22Myopathic facies (HP:0002058)3.40204164
23Increased connective tissue (HP:0009025)3.29793354
24Increased variability in muscle fiber diameter (HP:0003557)3.23844214
25Abnormality of skeletal muscle fiber size (HP:0012084)3.23090537
26Difficulty climbing stairs (HP:0003551)3.20064336
27Malignant hyperthermia (HP:0002047)3.17834598
28Mildly elevated creatine phosphokinase (HP:0008180)3.00773174
29Subaortic stenosis (HP:0001682)2.98970087
30Abnormality of the left ventricular outflow tract (HP:0011103)2.98970087
31Truncus arteriosus (HP:0001660)2.98912663
32Popliteal pterygium (HP:0009756)2.95503491
33Fatigable weakness (HP:0003473)2.94627649
34Abnormality of the neuromuscular junction (HP:0003398)2.94627649
35Trismus (HP:0000211)2.94135724
36Calcaneovalgus deformity (HP:0001848)2.93385179
37Abnormal finger flexion creases (HP:0006143)2.89497548
38Gowers sign (HP:0003391)2.89375357
39Sudden death (HP:0001699)2.85017503
40Ulnar claw (HP:0001178)2.74006780
41Broad metatarsal (HP:0001783)2.72032295
42Akinesia (HP:0002304)2.70281392
43Bulbar palsy (HP:0001283)2.70098191
44Deformed tarsal bones (HP:0008119)2.70018530
45Breech presentation (HP:0001623)2.69388586
46Distal lower limb amyotrophy (HP:0008944)2.59126123
47Hip contracture (HP:0003273)2.57898960
48Focal motor seizures (HP:0011153)2.57778767
49Dysmetric saccades (HP:0000641)2.54397786
50Progressive muscle weakness (HP:0003323)2.51058175
51Hyperthyroidism (HP:0000836)2.50130794
52Muscle stiffness (HP:0003552)2.47842721
53Myokymia (HP:0002411)2.43243489
54Neck muscle weakness (HP:0000467)2.43227253
55Cholecystitis (HP:0001082)2.41823735
56Abnormal gallbladder physiology (HP:0012438)2.41823735
57Action tremor (HP:0002345)2.37705578
58Lower limb amyotrophy (HP:0007210)2.36242121
59Aplasia of the musculature (HP:0100854)2.33145819
60Obstructive sleep apnea (HP:0002870)2.31922010
61Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.31554541
62Wrist flexion contracture (HP:0001239)2.31527094
63Myoglobinuria (HP:0002913)2.30875197
64Abnormality of placental membranes (HP:0011409)2.27672813
65Amniotic constriction ring (HP:0009775)2.27672813
66EMG: neuropathic changes (HP:0003445)2.25638692
67Shallow orbits (HP:0000586)2.21955822
68Limited hip movement (HP:0008800)2.21764631
69Bowel incontinence (HP:0002607)2.18425632
70Spinal rigidity (HP:0003306)2.15950007
71Scapular winging (HP:0003691)2.13543290
72Frequent falls (HP:0002359)2.12486000
73Hammertoe (HP:0001765)2.12101772
74Rhabdomyolysis (HP:0003201)2.11991640
75Termporal pattern (HP:0011008)2.11721269
76Insidious onset (HP:0003587)2.11721269
77Abnormal large intestine physiology (HP:0012700)2.09619114
78Pheochromocytoma (HP:0002666)2.08826003
79Thin ribs (HP:0000883)2.07467597
80Double outlet right ventricle (HP:0001719)2.07276961
81Congenital malformation of the right heart (HP:0011723)2.07276961
82Facial diplegia (HP:0001349)2.06552436
83Foot dorsiflexor weakness (HP:0009027)2.06298396
84Slender build (HP:0001533)2.05686959
85Heart block (HP:0012722)2.05175985
86Bell-shaped thorax (HP:0001591)2.03915260
87Shoulder girdle muscle weakness (HP:0003547)2.03292565
88Steppage gait (HP:0003376)2.03075519
89Abnormal atrioventricular conduction (HP:0005150)2.02789902
90Weak cry (HP:0001612)2.01529483
91Ventricular tachycardia (HP:0004756)2.00576663
92Proximal amyotrophy (HP:0007126)1.99658362
93Diaphragmatic weakness (HP:0009113)1.99620795
94Cholelithiasis (HP:0001081)1.99137422
95Ankle contracture (HP:0006466)1.98945362
96Type 2 muscle fiber atrophy (HP:0003554)1.98399978
97Atonic seizures (HP:0010819)1.98170549
98Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.96547122
99Muscle fiber atrophy (HP:0100295)1.94770583
100Hypercortisolism (HP:0001578)1.94042166
101Areflexia of lower limbs (HP:0002522)1.92072991
102Abnormality of the foot musculature (HP:0001436)1.91895719
103Reticulocytosis (HP:0001923)1.91750770
104Easy fatigability (HP:0003388)1.91558691
105Abnormality of the hip-girdle musculature (HP:0001445)1.90951963
106Abnormality of the musculature of the pelvis (HP:0001469)1.90951963
107Mask-like facies (HP:0000298)1.90874989
108Focal seizures (HP:0007359)1.89213858
109Metatarsus adductus (HP:0001840)1.88800250
110Limb-girdle muscle weakness (HP:0003325)1.85614291
111Respiratory insufficiency due to muscle weakness (HP:0002747)1.85325131
112Abnormality of the aortic arch (HP:0012303)1.84878046
113Neoplasm of the heart (HP:0100544)1.83557182
114Prolonged QT interval (HP:0001657)1.83546638
115Hypoplastic heart (HP:0001961)1.82739885
116Generalized muscle weakness (HP:0003324)1.82659980
117Stridor (HP:0010307)1.82577238
118Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82339250
119Nasal speech (HP:0001611)1.81877967
120Ankle clonus (HP:0011448)1.81341535
121Tarsal synostosis (HP:0008368)1.81326419
122Limb-girdle muscle atrophy (HP:0003797)1.81014400
123Hypoplastic ischia (HP:0003175)1.78989841
124Broad distal phalanx of finger (HP:0009836)1.78689305
125Visual hallucinations (HP:0002367)1.77071905
126Poor eye contact (HP:0000817)1.76716680
127Pelvic girdle muscle weakness (HP:0003749)1.75429773
128Ragged-red muscle fibers (HP:0003200)1.75221092
129Abnormality of the ischium (HP:0003174)1.73984393
130Neuroendocrine neoplasm (HP:0100634)1.73889665
131Chin dimple (HP:0010751)1.72573627
132Long clavicles (HP:0000890)1.72284045
133Bundle branch block (HP:0011710)1.72159783
134Distal lower limb muscle weakness (HP:0009053)1.72023303
135Abnormality of glycolysis (HP:0004366)1.69251113
136Ulnar deviation of finger (HP:0009465)1.69197512
137Synostosis involving bones of the lower limbs (HP:0009138)1.68101146
138Abnormality of the tricuspid valve (HP:0001702)1.67362803

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.78278677
2EEF2K3.74836948
3OBSCN3.37275836
4PHKG13.17390208
5PHKG23.17390208
6CDK193.11773096
7NTRK33.03173621
8MUSK2.93707433
9TTN2.65891996
10CAMKK22.56930678
11CAMK1G2.55404674
12ICK2.34121405
13CDK122.31092206
14TRIB32.25060399
15LMTK22.22782735
16CAMK1D2.20872953
17VRK22.07891668
18MOS1.98970310
19MARK11.98019957
20MAP2K71.91381369
21MAP3K91.82187422
22MAP3K101.79034105
23NME11.77816225
24KSR21.73579377
25LATS21.72848694
26MAP3K41.70856764
27LIMK11.62366990
28MINK11.60166819
29PIK3CG1.53025547
30PAK61.52423479
31NME21.51190311
32NTRK11.49170162
33MAPK131.44341180
34CAMKK11.42987581
35MAP2K41.42019062
36DMPK1.38734040
37MAP2K11.33779080
38PRKD31.31095681
39IRAK31.30530237
40DDR21.18773993
41BMX1.18686320
42CCNB11.17313150
43PNCK1.14330701
44FER1.12587245
45KSR11.12076109
46TTK1.09136777
47INSRR1.07909203
48RAF11.07070090
49BUB11.06810936
50PDGFRA1.05215429
51NTRK21.02825131
52DAPK21.01620337
53MTOR1.00188181
54TAF10.99758743
55MAP3K20.99317308
56EPHA40.98661964
57MAPKAPK50.94746057
58MAP3K70.94547791
59SIK10.92252968
60BRSK10.92028582
61PINK10.91617802
62GRK50.89983523
63CDK50.87126312
64RIPK40.85737667
65ERN10.84477663
66RIPK10.84325531
67RET0.82992542
68MAPK120.82634388
69ROCK10.82501101
70DAPK10.81764258
71IRAK20.81654908
72NEK10.79716402
73MARK20.78674135
74PAK30.78452255
75PDK30.76667521
76PDK40.76667521
77TAOK10.76046867
78ILK0.75676626
79TNIK0.75263899
80WNK10.74563200
81MYLK0.72729669
82TAOK20.72727428
83PRKCH0.72135587
84PLK20.70597281
85STK240.69808944
86CDK140.69108790
87BRAF0.68587111
88ERBB30.66612211
89CASK0.64530858
90ROCK20.63932709
91PTK60.62254852
92MAP2K60.62120480
93CSNK1G20.61997182
94CDK150.61676676
95CHEK20.61041167
96CAMK2G0.60491167
97MAPK110.60019426
98CAMK2A0.59746823
99CDK180.59319566
100RPS6KA20.58669213
101MAPK100.57590242
102CHEK10.56272418
103CDC42BPA0.56186200
104RPS6KB20.56000548
105MAP3K10.55992854
106ARAF0.55710014
107ADRBK10.55233964
108MAP2K30.55198804
109PRKAA10.54941301
110TESK10.54449468
111UHMK10.54428319
112FRK0.53474385
113MAP2K20.53328528
114SGK2230.52226422
115SGK4940.52226422
116CAMK10.52190568
117EPHB20.51952503
118PTK20.51523984
119MST1R0.51190528
120CDK11A0.49730883
121SIK20.49284782
122PRPF4B0.48143136
123AKT20.47899870
124PRKCG0.47699314
125WNK40.47348379
126SGK30.46924534
127DAPK30.46626339
128MAP3K80.46504087
129LATS10.45669679
130CAMK40.45427205
131SCYL20.45083892
132MAPKAPK30.45036757
133STK380.44964350
134EPHB10.43427175
135TRPM70.43349130
136PRKCE0.43054071
137PDPK10.42553806
138CAMK2D0.42514537
139CDK10.41022183
140PRKAA20.40948983
141SGK20.40709562
142CDK20.39797367
143PAK20.39474894
144CDK70.38688566
145PAK10.36933242
146CLK10.36546400
147TESK20.36457628
148EIF2AK10.35251310
149CAMK2B0.34350515
150AURKA0.34321729
151PDK20.32369235
152GSK3B0.30706818

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.76252973
2Dilated cardiomyopathy_Homo sapiens_hsa054142.19583450
3Sulfur relay system_Homo sapiens_hsa041222.18239761
4Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.10502716
5Cardiac muscle contraction_Homo sapiens_hsa042602.01052018
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.96116629
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.94664791
8Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.93709902
9Circadian entrainment_Homo sapiens_hsa047131.84515058
10Biosynthesis of amino acids_Homo sapiens_hsa012301.82414355
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.79287741
12Insulin secretion_Homo sapiens_hsa049111.77154672
13Synaptic vesicle cycle_Homo sapiens_hsa047211.76200374
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75795719
15Oxytocin signaling pathway_Homo sapiens_hsa049211.69229614
16DNA replication_Homo sapiens_hsa030301.62717769
17Dorso-ventral axis formation_Homo sapiens_hsa043201.62051061
18Long-term potentiation_Homo sapiens_hsa047201.61731450
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.57356830
20GABAergic synapse_Homo sapiens_hsa047271.56192038
21Dopaminergic synapse_Homo sapiens_hsa047281.52514747
22Carbon metabolism_Homo sapiens_hsa012001.52449086
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.51332903
24Nicotine addiction_Homo sapiens_hsa050331.49622378
25Olfactory transduction_Homo sapiens_hsa047401.48263534
26Salivary secretion_Homo sapiens_hsa049701.47705994
27* Cholinergic synapse_Homo sapiens_hsa047251.47554378
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47121639
29GnRH signaling pathway_Homo sapiens_hsa049121.46812989
30Amphetamine addiction_Homo sapiens_hsa050311.46738214
31Gastric acid secretion_Homo sapiens_hsa049711.43440718
32Taste transduction_Homo sapiens_hsa047421.41912666
33Glutamatergic synapse_Homo sapiens_hsa047241.39097636
34Arginine and proline metabolism_Homo sapiens_hsa003301.37546834
35Pentose phosphate pathway_Homo sapiens_hsa000301.36607331
36Vascular smooth muscle contraction_Homo sapiens_hsa042701.33549003
37Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.32616967
38Gap junction_Homo sapiens_hsa045401.29215188
39Renin secretion_Homo sapiens_hsa049241.29116404
40Insulin signaling pathway_Homo sapiens_hsa049101.29078638
41Vitamin B6 metabolism_Homo sapiens_hsa007501.28710170
42Calcium signaling pathway_Homo sapiens_hsa040201.26752915
43Glucagon signaling pathway_Homo sapiens_hsa049221.26019745
44Morphine addiction_Homo sapiens_hsa050321.23856096
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.23707683
46Notch signaling pathway_Homo sapiens_hsa043301.21611276
47Axon guidance_Homo sapiens_hsa043601.20585936
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.17235584
49Ribosome_Homo sapiens_hsa030101.17108372
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.16304358
51Estrogen signaling pathway_Homo sapiens_hsa049151.15146202
52Long-term depression_Homo sapiens_hsa047301.15115794
53Glioma_Homo sapiens_hsa052141.11869192
54Cocaine addiction_Homo sapiens_hsa050301.11243838
55Fructose and mannose metabolism_Homo sapiens_hsa000511.10261427
56Melanogenesis_Homo sapiens_hsa049161.09135764
57Serotonergic synapse_Homo sapiens_hsa047261.07772091
58Type II diabetes mellitus_Homo sapiens_hsa049301.07130781
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05961313
60Focal adhesion_Homo sapiens_hsa045101.04309880
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02561128
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.99692780
63cAMP signaling pathway_Homo sapiens_hsa040240.98888893
64mRNA surveillance pathway_Homo sapiens_hsa030150.98407907
65Insulin resistance_Homo sapiens_hsa049310.96564031
66ErbB signaling pathway_Homo sapiens_hsa040120.95991822
67Alzheimers disease_Homo sapiens_hsa050100.94180353
68Chronic myeloid leukemia_Homo sapiens_hsa052200.93623797
69Spliceosome_Homo sapiens_hsa030400.93235367
70Cell cycle_Homo sapiens_hsa041100.92162943
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91716154
72Pyruvate metabolism_Homo sapiens_hsa006200.91646165
73Arginine biosynthesis_Homo sapiens_hsa002200.90743363
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90297531
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.86808729
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84707489
77Circadian rhythm_Homo sapiens_hsa047100.83943289
78Base excision repair_Homo sapiens_hsa034100.82896667
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.82733602
80MAPK signaling pathway_Homo sapiens_hsa040100.82026820
81Non-small cell lung cancer_Homo sapiens_hsa052230.80995855
82mTOR signaling pathway_Homo sapiens_hsa041500.80845936
83Fatty acid biosynthesis_Homo sapiens_hsa000610.80670441
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.79987068
85Hedgehog signaling pathway_Homo sapiens_hsa043400.79797762
86Tight junction_Homo sapiens_hsa045300.79105641
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78611557
88AMPK signaling pathway_Homo sapiens_hsa041520.77541861
89RNA transport_Homo sapiens_hsa030130.74784387
90Lysine degradation_Homo sapiens_hsa003100.74272000
91Acute myeloid leukemia_Homo sapiens_hsa052210.74096214
92ECM-receptor interaction_Homo sapiens_hsa045120.73159640
93Parkinsons disease_Homo sapiens_hsa050120.72665030
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72381500
95Thyroid cancer_Homo sapiens_hsa052160.71014514
96Mismatch repair_Homo sapiens_hsa034300.70992241
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70666475
98Oxidative phosphorylation_Homo sapiens_hsa001900.70114523
99Phenylalanine metabolism_Homo sapiens_hsa003600.70067951
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.69641063
101Prion diseases_Homo sapiens_hsa050200.69554682
102Ras signaling pathway_Homo sapiens_hsa040140.69299880
103One carbon pool by folate_Homo sapiens_hsa006700.68524351
104Thyroid hormone synthesis_Homo sapiens_hsa049180.67155499
105Butanoate metabolism_Homo sapiens_hsa006500.65965411
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65482332
107Rap1 signaling pathway_Homo sapiens_hsa040150.65387272
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64384484
109Proteoglycans in cancer_Homo sapiens_hsa052050.64055683
110Endometrial cancer_Homo sapiens_hsa052130.64023943
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63189689
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62418767
113Wnt signaling pathway_Homo sapiens_hsa043100.61036383
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60050229
115VEGF signaling pathway_Homo sapiens_hsa043700.59969001
116Vibrio cholerae infection_Homo sapiens_hsa051100.59172143
117Renal cell carcinoma_Homo sapiens_hsa052110.59026692
118Pancreatic secretion_Homo sapiens_hsa049720.58928485
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58165824
120Melanoma_Homo sapiens_hsa052180.57952259
121Huntingtons disease_Homo sapiens_hsa050160.57526727
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57186136
123Pancreatic cancer_Homo sapiens_hsa052120.56074727
124Viral myocarditis_Homo sapiens_hsa054160.55072453
125Basal cell carcinoma_Homo sapiens_hsa052170.54726755
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53933060
127Collecting duct acid secretion_Homo sapiens_hsa049660.52434907
128Choline metabolism in cancer_Homo sapiens_hsa052310.51936899
129Amoebiasis_Homo sapiens_hsa051460.51802695
130Hippo signaling pathway_Homo sapiens_hsa043900.50311581
131HIF-1 signaling pathway_Homo sapiens_hsa040660.50222936
132Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49454027
133Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.49048083
134Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48995346
135Small cell lung cancer_Homo sapiens_hsa052220.48316774
136Ovarian steroidogenesis_Homo sapiens_hsa049130.48293337
137Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47304519
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46843444
139Oocyte meiosis_Homo sapiens_hsa041140.46821646
140Bladder cancer_Homo sapiens_hsa052190.46728645
141Fatty acid metabolism_Homo sapiens_hsa012120.46634054

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