KCNRG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which regulates the activity of voltage-gated potassium channels. This gene is on chromosome 13 and overlaps the gene for tripartite motif containing 13 on the same strand. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)8.59079682
2regulation of cilium movement (GO:0003352)7.28860004
3left/right pattern formation (GO:0060972)5.88200031
4left/right axis specification (GO:0070986)5.78572331
5cilium organization (GO:0044782)5.70871337
6cilium assembly (GO:0042384)5.53208189
7positive regulation of cellular amide metabolic process (GO:0034250)5.50105944
8protein localization to cilium (GO:0061512)5.23653332
9intraciliary transport (GO:0042073)5.07253079
10microtubule bundle formation (GO:0001578)4.96963805
11ventricular system development (GO:0021591)4.77314005
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.75416423
13positive regulation by organism of defense response of other organism involved in symbiotic interact4.75416423
14modulation by symbiont of host immune response (GO:0052553)4.75416423
15positive regulation by symbiont of host defense response (GO:0052509)4.75416423
16modulation by symbiont of host defense response (GO:0052031)4.75416423
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.75416423
18detection of molecule of bacterial origin (GO:0032490)4.73782005
19neutrophil activation involved in immune response (GO:0002283)4.72717617
20respiratory burst (GO:0045730)4.62282760
21positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.59380224
22cilium morphogenesis (GO:0060271)4.51632671
23cellular component assembly involved in morphogenesis (GO:0010927)4.42724249
24positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.32320885
25detection of other organism (GO:0098543)4.28141913
26diterpenoid biosynthetic process (GO:0016102)4.23216431
27regulation of microtubule-based movement (GO:0060632)4.20689815
28neutrophil mediated immunity (GO:0002446)4.13569426
29centriole assembly (GO:0098534)4.10232494
30positive regulation of mast cell activation (GO:0033005)3.98628425
31positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.94262488
32ether lipid metabolic process (GO:0046485)3.92965804
33negative regulation of T cell differentiation in thymus (GO:0033085)3.79721523
34tolerance induction (GO:0002507)3.78090174
35cell projection assembly (GO:0030031)3.77577851
36reactive oxygen species biosynthetic process (GO:1903409)3.71786344
37macrophage activation involved in immune response (GO:0002281)3.70824704
38alpha-linolenic acid metabolic process (GO:0036109)3.70742446
39pyrimidine-containing compound transmembrane transport (GO:0072531)3.70263868
40primary alcohol catabolic process (GO:0034310)3.68015569
41detection of external biotic stimulus (GO:0098581)3.67590804
42response to host immune response (GO:0052572)3.66804002
43response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.66804002
44negative regulation of B cell mediated immunity (GO:0002713)3.65244466
45negative regulation of immunoglobulin mediated immune response (GO:0002890)3.65244466
46positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.63650280
47modulation of growth of symbiont involved in interaction with host (GO:0044144)3.62742664
48regulation of growth of symbiont in host (GO:0044126)3.62742664
49negative regulation of growth of symbiont in host (GO:0044130)3.62742664
50negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.62742664
51neutrophil activation (GO:0042119)3.61314011
52microtubule depolymerization (GO:0007019)3.59290030
53microtubule-based movement (GO:0007018)3.56665976
54regulation of germinal center formation (GO:0002634)3.56618224
55granulocyte activation (GO:0036230)3.53693268
56sperm motility (GO:0030317)3.53541989
57response to host (GO:0075136)3.51041363
58response to host defenses (GO:0052200)3.51041363
59response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.51041363
60vitamin transmembrane transport (GO:0035461)3.50310864
61terpenoid biosynthetic process (GO:0016114)3.44757869
62nucleoside diphosphate phosphorylation (GO:0006165)3.43848395
63regulation of interferon-beta biosynthetic process (GO:0045357)3.42804042
64exogenous drug catabolic process (GO:0042738)3.40371983
65response to peptidoglycan (GO:0032494)3.39114617
66fatty acid elongation (GO:0030497)3.37943923
67regulation of cellular amide metabolic process (GO:0034248)3.34562599
68one-carbon compound transport (GO:0019755)3.29539001
69positive regulation of macrophage cytokine production (GO:0060907)3.27764476
70negative regulation of humoral immune response (GO:0002921)3.27297605
71detection of biotic stimulus (GO:0009595)3.26500969
72detection of bacterium (GO:0016045)3.24135326
73nonmotile primary cilium assembly (GO:0035058)3.21483087
74centriole replication (GO:0007099)3.19609304
75determination of left/right symmetry (GO:0007368)3.15808797
76complement activation, classical pathway (GO:0006958)3.15781660
77disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.15069184
78killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.15069184
79lipopolysaccharide-mediated signaling pathway (GO:0031663)3.07914277
80regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.06834086
81myeloid leukocyte mediated immunity (GO:0002444)3.04164962
82neural tube formation (GO:0001841)3.03537993
83glomerular epithelial cell development (GO:0072310)3.03253410
84negative regulation of complement activation (GO:0045916)3.01329886
85retinoic acid metabolic process (GO:0042573)2.99666083
86hydrogen peroxide biosynthetic process (GO:0050665)2.98954203
87positive regulation of mast cell activation involved in immune response (GO:0033008)2.98948633
88positive regulation of mast cell degranulation (GO:0043306)2.98948633
89positive regulation of gamma-delta T cell activation (GO:0046645)2.98590227
90protein neddylation (GO:0045116)2.96793111
91positive regulation of tolerance induction (GO:0002645)2.96435531
92positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.96089900
93determination of bilateral symmetry (GO:0009855)2.96036414
94behavioral response to nicotine (GO:0035095)2.93763828
95retinal rod cell development (GO:0046548)2.93121141
96positive regulation of leukocyte degranulation (GO:0043302)2.91866879
97apoptotic cell clearance (GO:0043277)2.91716111
98drug catabolic process (GO:0042737)2.91170260
99photoreceptor cell maintenance (GO:0045494)2.91123339
100retinal cone cell development (GO:0046549)2.90844763
101mitochondrial calcium ion homeostasis (GO:0051560)2.89323483
102specification of symmetry (GO:0009799)2.88182946
103mitochondrial calcium ion transport (GO:0006851)2.87104204
104antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.86788716
105antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.86788716
106positive regulation of p38MAPK cascade (GO:1900745)2.86750475
107smoothened signaling pathway (GO:0007224)2.86726731
108multicellular organism reproduction (GO:0032504)2.86134803
109protein polyglutamylation (GO:0018095)2.85999668
110complement activation (GO:0006956)2.84291075
111ethanol oxidation (GO:0006069)2.82504290
112negative regulation of protein activation cascade (GO:2000258)2.82081795
113regulation of interleukin-6 biosynthetic process (GO:0045408)2.81811367
114regulation of cholesterol biosynthetic process (GO:0045540)2.81550189
115regulation of leukocyte degranulation (GO:0043300)2.80215912
116response to muramyl dipeptide (GO:0032495)2.78805145
117rRNA catabolic process (GO:0016075)2.75074976
118myeloid cell activation involved in immune response (GO:0002275)2.75045293
119adaptation of signaling pathway (GO:0023058)2.74694747
120microtubule polymerization or depolymerization (GO:0031109)2.72487395
121regulation of mast cell activation (GO:0033003)2.71455466
122regulation of interleukin-5 production (GO:0032674)2.70822313
123cornea development in camera-type eye (GO:0061303)2.70704473
124sperm capacitation (GO:0048240)2.70640443
125very long-chain fatty acid metabolic process (GO:0000038)2.70114446
126regulation of myeloid leukocyte mediated immunity (GO:0002886)2.67773153
127microglial cell activation (GO:0001774)2.67710441
128glutathione derivative metabolic process (GO:1901685)2.66763748
129glutathione derivative biosynthetic process (GO:1901687)2.66763748
130positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.65778219
131myelin maintenance (GO:0043217)2.65284378
132negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.63672464
133negative regulation of interleukin-17 production (GO:0032700)2.63545138
134negative regulation of interleukin-12 production (GO:0032695)2.63164447
135positive regulation of toll-like receptor signaling pathway (GO:0034123)2.62409812
136production of molecular mediator involved in inflammatory response (GO:0002532)2.62119785
137regulation of chemokine biosynthetic process (GO:0045073)2.61967345
138negative regulation of protein localization to cell surface (GO:2000009)2.61521784
139regulation of interleukin-8 biosynthetic process (GO:0045414)2.60215920
140regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.59135445
141response to fungus (GO:0009620)2.59037175
142spinal cord motor neuron differentiation (GO:0021522)2.58991345
143L-fucose catabolic process (GO:0042355)2.58337160
144fucose catabolic process (GO:0019317)2.58337160
145L-fucose metabolic process (GO:0042354)2.58337160
146regulation of NFAT protein import into nucleus (GO:0051532)2.57918870
147negative regulation of interleukin-2 production (GO:0032703)2.56550394
148T-helper 1 type immune response (GO:0042088)2.55110676
149lateral ventricle development (GO:0021670)2.52800259
150regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.52251828
151axonemal dynein complex assembly (GO:0070286)2.52058134
152DNA deamination (GO:0045006)2.51468908
153antigen processing and presentation of endogenous antigen (GO:0019883)2.50797421
154negative regulation of myeloid cell apoptotic process (GO:0033033)2.49632468
155positive regulation of T cell chemotaxis (GO:0010820)2.49514967
156regulation of T cell chemotaxis (GO:0010819)2.49514967
157cytoplasmic microtubule organization (GO:0031122)2.49272198
158positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.48232594
159organelle assembly (GO:0070925)2.47547424
160cilium or flagellum-dependent cell motility (GO:0001539)2.47341100
161xenobiotic catabolic process (GO:0042178)2.45033858
162positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.44370105
163cellular ketone body metabolic process (GO:0046950)2.44186878
164positive regulation of B cell differentiation (GO:0045579)2.43749268
165regulation of regulated secretory pathway (GO:1903305)2.43114761
166response to xenobiotic stimulus (GO:0009410)2.42822121
167ethanol metabolic process (GO:0006067)2.42801274
168response to pheromone (GO:0019236)2.40309905
169lung epithelium development (GO:0060428)2.39682036
170neurotransmitter metabolic process (GO:0042133)2.37502671
171regulation of interleukin-13 production (GO:0032656)2.36889263
172organic cation transport (GO:0015695)2.36655427
173appendage development (GO:0048736)2.32688531
174limb development (GO:0060173)2.32688531
175sialylation (GO:0097503)2.32590508
176establishment or maintenance of monopolar cell polarity (GO:0061339)2.30507057
177establishment of monopolar cell polarity (GO:0061162)2.30507057
178superoxide anion generation (GO:0042554)2.29131866
179establishment of protein localization to Golgi (GO:0072600)2.28982006
180negative regulation of adaptive immune response (GO:0002820)2.26115879
181microtubule-based process (GO:0007017)2.21460249
182benzene-containing compound metabolic process (GO:0042537)2.20914494
183retinol metabolic process (GO:0042572)2.20682737
184excretion (GO:0007588)2.20130267
185phosphatidylcholine biosynthetic process (GO:0006656)2.17105678
186detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.16851883
187photoreceptor cell development (GO:0042461)2.15143732
188respiratory chain complex IV assembly (GO:0008535)2.14583266
189cilium movement (GO:0003341)12.1119061
190epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)12.0837898
191epithelial cilium movement (GO:0003351)11.0043856
192motile cilium assembly (GO:0044458)10.2365270

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human4.73611374
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.57200327
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.16703757
4SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.04367211
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.00948915
6VDR_22108803_ChIP-Seq_LS180_Human2.92065675
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.75985787
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.75407879
9ZNF274_21170338_ChIP-Seq_K562_Hela2.68448935
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.64368804
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.58605776
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.58355648
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.56557230
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.54297086
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.51913970
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.43511577
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.37920500
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.37632517
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.37172133
20LXR_22158963_ChIP-Seq_LIVER_Mouse2.20198954
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.19064513
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.17287418
23TAF15_26573619_Chip-Seq_HEK293_Human2.11144037
24RXR_22158963_ChIP-Seq_LIVER_Mouse2.10314390
25IGF1R_20145208_ChIP-Seq_DFB_Human2.03629864
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.02760736
27EWS_26573619_Chip-Seq_HEK293_Human1.99608872
28NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.99140066
29NRF2_20460467_ChIP-Seq_MEFs_Mouse1.99140066
30GBX2_23144817_ChIP-Seq_PC3_Human1.98585945
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.98391814
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.98086571
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97928730
34RUNX_20019798_ChIP-Seq_JUKART_Human1.97875161
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.91927698
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.91684803
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89783377
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.88854976
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88421546
40FUS_26573619_Chip-Seq_HEK293_Human1.87444706
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85429311
42SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.84446804
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.83254176
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82099306
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.80639235
46CLOCK_20551151_ChIP-Seq_293T_Human1.80476264
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.77440666
48ESR1_21235772_ChIP-Seq_MCF-7_Human1.77211856
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76051413
50PPARA_22158963_ChIP-Seq_LIVER_Mouse1.73779119
51SMAD4_21799915_ChIP-Seq_A2780_Human1.72956973
52P300_19829295_ChIP-Seq_ESCs_Human1.70336918
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.67238884
54STAT3_23295773_ChIP-Seq_U87_Human1.66530727
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60987433
56SCL_19346495_ChIP-Seq_HPC-7_Human1.59822764
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.59804704
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57739190
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.55427772
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.55391782
61POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.54540719
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54540719
63EGR1_23403033_ChIP-Seq_LIVER_Mouse1.53614214
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52682224
65CBP_20019798_ChIP-Seq_JUKART_Human1.52682224
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51684440
67* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51624548
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.49849332
69NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.49760309
70TCF4_23295773_ChIP-Seq_U87_Human1.47553388
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46152003
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.45094255
73VDR_24763502_ChIP-Seq_THP-1_Human1.43679704
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41249828
75CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.40937471
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40678135
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.40652422
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40398101
79VDR_24787735_ChIP-Seq_THP-1_Human1.39341653
80AR_25329375_ChIP-Seq_VCAP_Human1.38730847
81TCF4_22108803_ChIP-Seq_LS180_Human1.38187820
82FOXM1_26456572_ChIP-Seq_MCF-7_Human1.37511548
83PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37088705
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35093064
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.30914624
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29934415
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.29466264
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28763847
89PRDM14_20953172_ChIP-Seq_ESCs_Human1.27662280
90* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27536490
91* FOXA1_25329375_ChIP-Seq_VCAP_Human1.27536490
92NANOG_19829295_ChIP-Seq_ESCs_Human1.26875358
93SOX2_19829295_ChIP-Seq_ESCs_Human1.26875358
94GATA1_19941826_ChIP-Seq_K562_Human1.26816657
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26720000
96AR_20517297_ChIP-Seq_VCAP_Human1.25822596
97NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25720802
98FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25581221
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.25072583
100PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24641738
101FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23739159
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.23610592
103CDX2_22108803_ChIP-Seq_LS180_Human1.23014334
104PU_27001747_Chip-Seq_BMDM_Mouse1.22283905
105FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22121215
106ETV1_20927104_ChIP-Seq_GIST48_Human1.21967671
107* RUNX2_22187159_ChIP-Seq_PCA_Human1.21465048
108P53_22387025_ChIP-Seq_ESCs_Mouse1.20218275
109IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19740649
110* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19592100
111STAT4_19710469_ChIP-ChIP_TH1__Mouse1.19476241
112SMRT_27268052_Chip-Seq_Bcells_Human1.19201878
113SMAD4_21741376_ChIP-Seq_EPCs_Human1.16518176
114PHF8_20622853_ChIP-Seq_HELA_Human1.14386413
115VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14308384
116GATA2_21666600_ChIP-Seq_HMVEC_Human1.13220779
117SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12688902
118GATA3_21878914_ChIP-Seq_MCF-7_Human1.11690613
119GATA2_19941826_ChIP-Seq_K562_Human1.11258739
120SOX2_20726797_ChIP-Seq_SW620_Human1.10999335
121PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.10656010
122NCOR_22424771_ChIP-Seq_293T_Human1.10255116
123GATA3_27048872_Chip-Seq_THYMUS_Human1.09941480
124PPAR_26484153_Chip-Seq_NCI-H1993_Human1.09835475
125TP53_22573176_ChIP-Seq_HFKS_Human1.09420375
126MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09045185
127CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08983856
128MYB_26560356_Chip-Seq_TH2_Human1.07903669
129TP63_23658742_ChIP-Seq_EP156T_Human1.07543215
130E2F1_18555785_Chip-Seq_ESCs_Mouse1.07081550
131RBPJ_21746931_ChIP-Seq_IB4_Human1.06969536
132CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06547943
133STAT3_18555785_Chip-Seq_ESCs_Mouse1.06476531
134TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.06386316
135E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05998815
136TDRD3_21172665_ChIP-Seq_MCF-7_Human1.05634736
137PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05460952
138GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05292356
139ZNF263_19887448_ChIP-Seq_K562_Human1.05149588
140TP53_16413492_ChIP-PET_HCT116_Human1.04825694
141NFYA_21822215_ChIP-Seq_K562_Human1.04467007
142KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04389630
143NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04356822
144TBL1_22424771_ChIP-Seq_293T_Human1.04210394
145CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03614242
146FLI1_21867929_ChIP-Seq_TH2_Mouse1.02509564
147CRX_20693478_ChIP-Seq_RETINA_Mouse1.02405998
148ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01341615
149ESR2_21235772_ChIP-Seq_MCF-7_Human1.01320437
150NFYB_21822215_ChIP-Seq_K562_Human1.00943429
151HNFA_21074721_ChIP-Seq_CACO-2_Human1.00594703
152SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00504368
153BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99821145
154ER_23166858_ChIP-Seq_MCF-7_Human0.99681477
155EGR1_19032775_ChIP-ChIP_M12_Human0.97221732
156SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96704204
157CDX2_20551321_ChIP-Seq_CACO-2_Human0.95639925
158NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93645967
159TP53_18474530_ChIP-ChIP_U2OS_Human0.92432325
160BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91369546
161AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91251622
162RUNX1_22412390_ChIP-Seq_EML_Mouse0.90675026
163CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90162502
164PIAS1_25552417_ChIP-Seq_VCAP_Human0.89236405
165PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88762393
166RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.88506870
167TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88269888
168* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87846180
169CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86725517
170ESR1_20079471_ChIP-ChIP_T-47D_Human0.85070372
171CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.84914571
172* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84783913
173VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.84243714
174FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.84044680
175SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83639514
176GATA3_26560356_Chip-Seq_TH2_Human0.82923386
177DROSHA_22980978_ChIP-Seq_HELA_Human0.81595945
178SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.81451434
179SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.81451434
180NFIB_24661679_ChIP-Seq_LUNG_Mouse0.81413372
181POU3F2_20337985_ChIP-ChIP_501MEL_Human0.81258131
182AHR_22903824_ChIP-Seq_MCF-7_Human0.81067878
183SPI1_23547873_ChIP-Seq_NB4_Human0.80456815
184BCAT_22108803_ChIP-Seq_LS180_Human0.79612109
185CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79137354
186AR_21572438_ChIP-Seq_LNCaP_Human0.77817254

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology5.08071181
2MP0002139_abnormal_hepatobiliary_system3.79719087
3MP0001984_abnormal_olfaction3.01022958
4MP0004043_abnormal_pH_regulation2.90856981
5MP0003436_decreased_susceptibility_to2.89805414
6MP0003075_altered_response_to2.88021757
7MP0005365_abnormal_bile_salt2.84659081
8MP0003724_increased_susceptibility_to2.82175401
9MP0002009_preneoplasia2.73151538
10MP0009785_altered_susceptibility_to2.68057607
11MP0003656_abnormal_erythrocyte_physiolo2.67679243
12MP0004133_heterotaxia2.63301110
13MP0003787_abnormal_imprinting2.61147205
14MP0003303_peritoneal_inflammation2.59170670
15MP0003950_abnormal_plasma_membrane2.58620835
16MP0002419_abnormal_innate_immunity2.58448424
17MP0000569_abnormal_digit_pigmentation2.55051857
18MP0002166_altered_tumor_susceptibility2.40064444
19MP0008877_abnormal_DNA_methylation2.39542017
20MP0005164_abnormal_response_to2.39334416
21MP0003690_abnormal_glial_cell2.38883942
22MP0008875_abnormal_xenobiotic_pharmacok2.32680371
23MP0004883_abnormal_blood_vessel2.24857721
24MP0005083_abnormal_biliary_tract2.24213529
25MP0009780_abnormal_chondrocyte_physiolo2.18066351
26MP0005551_abnormal_eye_electrophysiolog2.17361205
27MP0005058_abnormal_lysosome_morphology2.12878293
28MP0002006_tumorigenesis2.11501120
29MP0000920_abnormal_myelination2.10909826
30MP0003195_calcinosis2.08612604
31MP0002132_abnormal_respiratory_system2.08074324
32MP0008789_abnormal_olfactory_epithelium1.98664884
33MP0005000_abnormal_immune_tolerance1.98282594
34MP0005085_abnormal_gallbladder_physiolo1.97656230
35MP0002876_abnormal_thyroid_physiology1.97030468
36MP0001853_heart_inflammation1.96547483
37MP0009764_decreased_sensitivity_to1.94051038
38MP0005025_abnormal_response_to1.93346822
39MP0005671_abnormal_response_to1.85942971
40MP0002102_abnormal_ear_morphology1.85122778
41MP0008872_abnormal_physiological_respon1.84404475
42MP0000383_abnormal_hair_follicle1.84234506
43MP0003191_abnormal_cellular_cholesterol1.84156148
44MP0009046_muscle_twitch1.82135250
45MP0002148_abnormal_hypersensitivity_rea1.79654429
46MP0005645_abnormal_hypothalamus_physiol1.78757776
47MP0001790_abnormal_immune_system1.78662370
48MP0005387_immune_system_phenotype1.78662370
49MP0001835_abnormal_antigen_presentation1.78059394
50MP0000343_altered_response_to1.72611325
51MP0005166_decreased_susceptibility_to1.69792004
52MP0005377_hearing/vestibular/ear_phenot1.67935116
53MP0003878_abnormal_ear_physiology1.67935116
54MP0000604_amyloidosis1.66212065
55MP0002452_abnormal_antigen_presenting1.65419432
56MP0003329_amyloid_beta_deposits1.59485072
57MP0001968_abnormal_touch/_nociception1.59180861
58MP0001800_abnormal_humoral_immune1.57560713
59MP0005464_abnormal_platelet_physiology1.53084685
60MP0003448_altered_tumor_morphology1.51647193
61MP0002420_abnormal_adaptive_immunity1.50653077
62MP0001819_abnormal_immune_cell1.49439216
63MP0005646_abnormal_pituitary_gland1.48802836
64MP0002160_abnormal_reproductive_system1.47934993
65MP0001485_abnormal_pinna_reflex1.46934771
66MP0002909_abnormal_adrenal_gland1.46860532
67MP0005451_abnormal_body_composition1.46570266
68MP0002933_joint_inflammation1.45964159
69MP0001533_abnormal_skeleton_physiology1.45486862
70MP0005253_abnormal_eye_physiology1.44493613
71MP0001765_abnormal_ion_homeostasis1.43311813
72MP0005360_urolithiasis1.43191784
73MP0003186_abnormal_redox_activity1.41609962
74MP0001845_abnormal_inflammatory_respons1.41042489
75MP0000427_abnormal_hair_cycle1.40492027
76MP0002723_abnormal_immune_serum1.40451184
77MP0004782_abnormal_surfactant_physiolog1.40225089
78MP0001986_abnormal_taste_sensitivity1.38551398
79MP0002736_abnormal_nociception_after1.37841975
80MP0005174_abnormal_tail_pigmentation1.36276091
81MP0010234_abnormal_vibrissa_follicle1.32073820
82MP0002277_abnormal_respiratory_mucosa1.31511094
83MP0009745_abnormal_behavioral_response1.29492409
84MP0002168_other_aberrant_phenotype1.26457371
85MP0005394_taste/olfaction_phenotype1.25505915
86MP0005499_abnormal_olfactory_system1.25505915
87MP0005389_reproductive_system_phenotype1.22734737
88MP0002735_abnormal_chemical_nociception1.21100291
89MP0010678_abnormal_skin_adnexa1.19637145
90MP0001529_abnormal_vocalization1.18918551
91MP0001486_abnormal_startle_reflex1.18562248
92MP0002998_abnormal_bone_remodeling1.18359443
93MP0002638_abnormal_pupillary_reflex1.18248546
94MP0005636_abnormal_mineral_homeostasis1.17343765
95MP0000631_abnormal_neuroendocrine_gland1.17231720
96MP0008469_abnormal_protein_level1.15583728
97MP0000858_altered_metastatic_potential1.14948263
98MP0002928_abnormal_bile_duct1.13158580
99MP0003828_pulmonary_edema1.12824325
100MP0001970_abnormal_pain_threshold1.12241879
101MP0005187_abnormal_penis_morphology1.11829039
102MP0004019_abnormal_vitamin_homeostasis1.10853379
103MP0003646_muscle_fatigue1.10519549
104MP0001958_emphysema1.10130236
105MP0005332_abnormal_amino_acid1.10042417
106MP0004142_abnormal_muscle_tone1.08707828
107MP0002272_abnormal_nervous_system1.08294361
108MP0004885_abnormal_endolymph1.05508793
109MP0003698_abnormal_male_reproductive1.05415085
110MP0010155_abnormal_intestine_physiology1.05352888
111MP0005310_abnormal_salivary_gland1.04009463
112MP0000716_abnormal_immune_system1.03912204
113MP0003183_abnormal_peptide_metabolism1.03784649
114MP0002734_abnormal_mechanical_nocicepti1.03172929
115MP0002163_abnormal_gland_morphology1.02896856
116MP0001849_ear_inflammation1.02256508
117MP0002090_abnormal_vision1.01412232
118MP0003633_abnormal_nervous_system1.00907850
119MP0005084_abnormal_gallbladder_morpholo1.00232524
120MP0008995_early_reproductive_senescence1.00080259
121MP0001851_eye_inflammation0.99543062
122MP0010329_abnormal_lipoprotein_level0.98522092
123MP0003045_fibrosis0.98371208
124MP0000685_abnormal_immune_system0.97952938
125MP0009763_increased_sensitivity_to0.97187172
126MP0005167_abnormal_blood-brain_barrier0.96884726
127MP0003136_yellow_coat_color0.96300356
128MP0006082_CNS_inflammation0.95184956
129MP0003566_abnormal_cell_adhesion0.94917484
130MP0006072_abnormal_retinal_apoptosis0.94303163
131MP0002254_reproductive_system_inflammat0.94226785
132MP0000465_gastrointestinal_hemorrhage0.93375025
133MP0002282_abnormal_trachea_morphology0.93335531
134MP0001542_abnormal_bone_strength0.92020259
135MP0002229_neurodegeneration0.91820591
136MP0003011_delayed_dark_adaptation0.91742629
137MP0009379_abnormal_foot_pigmentation0.91582422
138MP0002118_abnormal_lipid_homeostasis0.91429707
139MP0001929_abnormal_gametogenesis0.90577612
140MP0001545_abnormal_hematopoietic_system0.89525861
141MP0005397_hematopoietic_system_phenotyp0.89525861
142MP0005584_abnormal_enzyme/coenzyme_acti0.89519661
143MP0003091_abnormal_cell_migration0.89115190
144MP0001666_abnormal_nutrient_absorption0.89113408
145MP0002398_abnormal_bone_marrow0.88246536
146MP0002837_dystrophic_cardiac_calcinosis0.87834623
147MP0004264_abnormal_extraembryonic_tissu0.87087098
148MP0003632_abnormal_nervous_system0.86972373
149MP0004147_increased_porphyrin_level0.85993999
150MP0005395_other_phenotype0.85404547
151MP0005408_hypopigmentation0.84647703
152MP0002067_abnormal_sensory_capabilities0.83499545
153MP0003121_genomic_imprinting0.83183275
154MP0002572_abnormal_emotion/affect_behav0.82949486
155MP0004947_skin_inflammation0.82213028
156MP0002396_abnormal_hematopoietic_system0.81782551
157MP0005195_abnormal_posterior_eye0.81286903
158MP0000647_abnormal_sebaceous_gland0.81168678
159MP0000609_abnormal_liver_physiology0.80989470
160MP0002557_abnormal_social/conspecific_i0.80545052
161MP0009333_abnormal_splenocyte_physiolog0.79673423
162MP0002405_respiratory_system_inflammati0.79603261
163MP0004185_abnormal_adipocyte_glucose0.78924608
164MP0004742_abnormal_vestibular_system0.78872831
165MP0003631_nervous_system_phenotype0.78675713
166MP0005165_increased_susceptibility_to0.77187833
167MP0005023_abnormal_wound_healing0.76286217
168MP0006276_abnormal_autonomic_nervous0.76203117
169MP0001502_abnormal_circadian_rhythm0.76095201
170MP0004215_abnormal_myocardial_fiber0.76071874
171MP0002095_abnormal_skin_pigmentation0.74738332
172MP0002429_abnormal_blood_cell0.73912808
173MP0004484_altered_response_of0.73474618
174MP0005410_abnormal_fertilization0.72202295
175MP0003866_abnormal_defecation0.72173977
176MP0005386_behavior/neurological_phenoty0.71648082
177MP0004924_abnormal_behavior0.71648082
178MP0001919_abnormal_reproductive_system0.71347229
179MP0001188_hyperpigmentation0.69716609
180MP0000026_abnormal_inner_ear0.68785758
181MP0002064_seizures0.67949949
182MP0000230_abnormal_systemic_arterial0.67609631

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)9.64299442
2Dynein arm defect of respiratory motile cilia (HP:0012255)9.64299442
3Abnormal respiratory motile cilium physiology (HP:0012261)9.10651185
4Rhinitis (HP:0012384)8.37388495
5Bronchiectasis (HP:0002110)6.16711959
6Recurrent gram-negative bacterial infections (HP:0005420)5.34693321
7Chronic otitis media (HP:0000389)5.30563901
8Recurrent abscess formation (HP:0002722)4.90433572
9Abnormality of macrophages (HP:0004311)4.90291656
10Recurrent bacterial skin infections (HP:0005406)4.79985436
11Hypochromic microcytic anemia (HP:0004840)4.50877824
12Pancreatic fibrosis (HP:0100732)4.44576990
13Eczematoid dermatitis (HP:0000976)4.30876775
14True hermaphroditism (HP:0010459)4.29145015
15Pancreatic cysts (HP:0001737)4.17279206
16Orchitis (HP:0100796)3.98681920
17Myositis (HP:0100614)3.91668174
18Molar tooth sign on MRI (HP:0002419)3.88099203
19Abnormality of midbrain morphology (HP:0002418)3.88099203
20Enlarged kidneys (HP:0000105)3.74935829
21Nephronophthisis (HP:0000090)3.73394893
22Chronic sinusitis (HP:0011109)3.62223393
23Infertility (HP:0000789)3.52691791
24Retrobulbar optic neuritis (HP:0100654)3.49071370
25Optic neuritis (HP:0100653)3.49071370
26Neurofibrillary tangles (HP:0002185)3.44803064
27Recurrent sinusitis (HP:0011108)3.31666255
28Occipital encephalocele (HP:0002085)3.28541570
29Cystic liver disease (HP:0006706)3.16822591
30Abnormality of the renal medulla (HP:0100957)3.07020634
31Cellulitis (HP:0100658)3.03522254
32Chronic hepatic failure (HP:0100626)3.01566578
33Interstitial pulmonary disease (HP:0006530)2.98347491
34Medial flaring of the eyebrow (HP:0010747)2.95268151
35Abnormality of the common coagulation pathway (HP:0010990)2.91153759
36Abnormal respiratory motile cilium morphology (HP:0005938)2.90967487
37Abnormal respiratory epithelium morphology (HP:0012253)2.90967487
38Spontaneous hematomas (HP:0007420)2.89829913
39Recurrent skin infections (HP:0001581)2.89491724
40Hyperlipoproteinemia (HP:0010980)2.87298138
41Postaxial foot polydactyly (HP:0001830)2.80693153
42Severe Myopia (HP:0011003)2.79281561
43Male infertility (HP:0003251)2.76422912
44Xanthomatosis (HP:0000991)2.76269556
45Recurrent otitis media (HP:0000403)2.75986912
46Joint hemorrhage (HP:0005261)2.75381145
47Clumsiness (HP:0002312)2.73655726
48Anencephaly (HP:0002323)2.65744602
49Disinhibition (HP:0000734)2.61607349
50Gingivitis (HP:0000230)2.56521533
51Hypochromic anemia (HP:0001931)2.52614347
52Aplasia/Hypoplasia of the tongue (HP:0010295)2.52151005
53Intrahepatic cholestasis (HP:0001406)2.51471855
54Abnormality of monocarboxylic acid metabolism (HP:0010996)2.50730727
55Pustule (HP:0200039)2.50313224
56Periodontitis (HP:0000704)2.49185524
57Meningitis (HP:0001287)2.45544457
58Amyloidosis (HP:0011034)2.45541005
59Absent rod-and cone-mediated responses on ERG (HP:0007688)2.43630234
60Osteomyelitis (HP:0002754)2.42830029
61Congenital hepatic fibrosis (HP:0002612)2.42684022
62Congenital primary aphakia (HP:0007707)2.42532616
63Gait imbalance (HP:0002141)2.42314202
64Cerebral inclusion bodies (HP:0100314)2.39349242
65Chronic bronchitis (HP:0004469)2.39205876
66Pulmonary embolism (HP:0002204)2.34453528
67Male pseudohermaphroditism (HP:0000037)2.33439381
68Loss of speech (HP:0002371)2.32159089
69Keratoconjunctivitis sicca (HP:0001097)2.32072776
70Chronic obstructive pulmonary disease (HP:0006510)2.31971067
71Obstructive lung disease (HP:0006536)2.31971067
72Nasal polyposis (HP:0100582)2.31601648
73Mediastinal lymphadenopathy (HP:0100721)2.31485333
74Decreased central vision (HP:0007663)2.30387838
75Hematochezia (HP:0002573)2.29997904
76Furrowed tongue (HP:0000221)2.29526577
77Deep venous thrombosis (HP:0002625)2.29233172
78Abnormality of the renal cortex (HP:0011035)2.27376448
79Increased neuronal autofluorescent lipopigment (HP:0002074)2.26901289
80Nephrogenic diabetes insipidus (HP:0009806)2.24444047
81Tubular atrophy (HP:0000092)2.23318047
82Sclerocornea (HP:0000647)2.23140329
83Abnormality of the nasal mucosa (HP:0000433)2.19036118
84Pulmonic stenosis (HP:0001642)2.17704028
85Recurrent pneumonia (HP:0006532)2.16591326
86Gingival bleeding (HP:0000225)2.15426637
87Decreased circulating renin level (HP:0003351)2.15072827
88Intention tremor (HP:0002080)2.15016028
89Pulmonary infiltrates (HP:0002113)2.14390351
90Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.13377165
91Gout (HP:0001997)2.12679308
92Systemic lupus erythematosus (HP:0002725)2.10512130
93Vasculitis (HP:0002633)2.09880209
94Sepsis (HP:0100806)2.06306980
95Dysostosis multiplex (HP:0000943)2.06004627
96Abnormal rod and cone electroretinograms (HP:0008323)2.05675254
97Keratoconjunctivitis (HP:0001096)2.04573045
98Aortic valve stenosis (HP:0001650)2.04266668
99Increased cerebral lipofuscin (HP:0011813)2.04040929
100Eosinophilia (HP:0001880)2.02780683
101Esophageal atresia (HP:0002032)2.01866771
102Clitoromegaly (HP:0000057)1.99301680
103Leukocytosis (HP:0001974)1.96946206
104Postaxial hand polydactyly (HP:0001162)1.95836697
105Recurrent viral infections (HP:0004429)1.95532571
106Abnormality of aromatic amino acid family metabolism (HP:0004338)1.93745823
107Tubulointerstitial nephritis (HP:0001970)1.93535034
108Increased serum ferritin (HP:0003281)1.92611618
109Termporal pattern (HP:0011008)1.92025799
110Insidious onset (HP:0003587)1.92025799
111Arterial thrombosis (HP:0004420)1.90292784
112Abnormality of iron homeostasis (HP:0011031)1.90111785
113Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.88658182
114Glomerulonephritis (HP:0000099)1.88618520
115Bronchitis (HP:0012387)1.88343158
116Prolonged partial thromboplastin time (HP:0003645)1.88241994
117Abnormal drinking behavior (HP:0030082)1.87286703
118Polydipsia (HP:0001959)1.87286703
119Elevated erythrocyte sedimentation rate (HP:0003565)1.87251115
120Genital tract atresia (HP:0001827)1.85979552
121Inappropriate behavior (HP:0000719)1.85844211
122Urticaria (HP:0001025)1.85142454
123Aplasia/Hypoplasia of the spleen (HP:0010451)1.83724159
124Bifid scrotum (HP:0000048)1.83331864
125Prolonged neonatal jaundice (HP:0006579)1.83217003
126Abnormality of transition element cation homeostasis (HP:0011030)1.82112442
127Infantile muscular hypotonia (HP:0008947)1.82044580
128Pancreatitis (HP:0001733)1.81222741
129Recurrent fungal infections (HP:0002841)1.81121535
130Asplenia (HP:0001746)1.80873360
131Complement deficiency (HP:0004431)1.80650844
132Abnormality of the heme biosynthetic pathway (HP:0010472)1.80409571
133Gastrointestinal stroma tumor (HP:0100723)1.80180923
134Vaginal atresia (HP:0000148)1.78759613
135Hyperactive renin-angiotensin system (HP:0000841)1.78487347
136Oculomotor apraxia (HP:0000657)1.78197876
137Hypertriglyceridemia (HP:0002155)1.77967410
138Mutism (HP:0002300)1.77525127
139Abnormal ciliary motility (HP:0012262)1.76919197
140Poor coordination (HP:0002370)1.76484992
141Broad metatarsal (HP:0001783)1.75539436
142Supranuclear gaze palsy (HP:0000605)1.74950563
143Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.72656450
144Hepatosplenomegaly (HP:0001433)1.72016020
145Attenuation of retinal blood vessels (HP:0007843)1.69541658
146Thyroiditis (HP:0100646)1.69342404
147Recurrent bronchitis (HP:0002837)1.67308610
148Absent speech (HP:0001344)1.64942206
149Congenital stationary night blindness (HP:0007642)1.63943646
150Abnormality of macular pigmentation (HP:0008002)1.63032061
151Hyperventilation (HP:0002883)1.59046229
152Nephropathy (HP:0000112)1.55321559
153Abolished electroretinogram (ERG) (HP:0000550)1.55168488
154Type II lissencephaly (HP:0007260)1.52896529
155Disproportionate short-trunk short stature (HP:0003521)1.50293815
156Preaxial hand polydactyly (HP:0001177)1.45280051
157Renal salt wasting (HP:0000127)1.44106500
158Broad-based gait (HP:0002136)1.44091806
159Gaze-evoked nystagmus (HP:0000640)1.43074168
160Abnormality of renin-angiotensin system (HP:0000847)1.42738991
161Atelectasis (HP:0100750)1.41287738
162Median cleft lip (HP:0000161)1.36449100
163Hyperkalemia (HP:0002153)1.36173669
164Stage 5 chronic kidney disease (HP:0003774)1.35703506
165Hyperaldosteronism (HP:0000859)1.34935407
166Increased corneal curvature (HP:0100692)1.34625430
167Keratoconus (HP:0000563)1.34625430
168Pendular nystagmus (HP:0012043)1.34358552
169Retinitis pigmentosa (HP:0000510)1.33523735
170Polyuria (HP:0000103)1.33471638
171Hypokalemic alkalosis (HP:0001949)1.31936327
172Widely spaced teeth (HP:0000687)1.31738716
173Renal cortical cysts (HP:0000803)1.31525291
174Bony spicule pigmentary retinopathy (HP:0007737)1.30699176
175Narrow forehead (HP:0000341)1.30075644
176Carpal bone hypoplasia (HP:0001498)1.29389070
177Hip dysplasia (HP:0001385)1.27915310
178Tubulointerstitial abnormality (HP:0001969)1.26449110
179Specific learning disability (HP:0001328)1.23620568
180Multicystic kidney dysplasia (HP:0000003)1.21506129
181Aganglionic megacolon (HP:0002251)1.20478132
182Abnormality of chloride homeostasis (HP:0011422)1.20445608
183Prominent nasal bridge (HP:0000426)1.20090685
184Constricted visual fields (HP:0001133)1.19255360
185Abnormal biliary tract physiology (HP:0012439)1.15627215
186Bile duct proliferation (HP:0001408)1.15627215
187Agitation (HP:0000713)1.15320213
188Barrel-shaped chest (HP:0001552)1.14911392

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.73719222
2FGFR25.61504772
3MST45.14277001
4RIPK44.06295441
5ERN13.74935754
6FGFR43.03529574
7GRK72.85475761
8MAP3K102.70515681
9EPHB12.41172957
10ADRBK22.38745086
11MAP3K142.35871760
12TGFBR22.27056546
13MAP3K42.21250808
14ITK2.20054048
15ZAP702.18361070
16YES12.14730660
17TYRO32.13460034
18FGFR32.09215522
19PNCK2.01520797
20ACVR1B2.00523514
21INSRR1.90938433
22PTK2B1.82193891
23TLK11.76457259
24MAPKAPK31.73369248
25GRK11.71926623
26WNK41.71114380
27MAP4K21.58377506
28WNK31.55320725
29NUAK11.53680308
30CAMKK21.53252033
31ZAK1.39970291
32PDGFRB1.36527412
33MAP4K11.35780241
34LATS11.31251470
35MAPK131.30788795
36STK101.30410313
37TNIK1.21775282
38PIM21.21537841
39STK241.21418224
40MAPK71.17886530
41NTRK21.14157973
42TEC1.12212096
43FRK1.11182029
44PAK31.10461237
45HCK1.10250906
46SYK1.09744119
47PDGFRA1.09229582
48ERBB31.08429442
49MAP2K31.08374214
50JAK21.03514211
51ADRBK11.02708698
52CAMK1G1.01955895
53TBK10.99753932
54TXK0.99403651
55MAP2K70.99025947
56CLK10.98600715
57NLK0.97851728
58STK30.97456123
59NME10.96320309
60LYN0.95613845
61CSK0.94687452
62EPHA40.90509860
63PRPF4B0.89256376
64BMPR1B0.89136210
65TYK20.87972576
66BRSK20.87822682
67MAPK40.87806135
68CASK0.86730307
69EPHA20.85822947
70MKNK20.84870507
71IRAK10.81911370
72CAMK1D0.81862019
73STK110.81742868
74LRRK20.81188699
75JAK10.80521502
76UHMK10.80233000
77CAMK2B0.80195488
78TRPM70.79979203
79MAP3K30.79690868
80TAOK30.78530744
81SIK30.76702370
82BTK0.76315712
83ERBB20.75543441
84GRK60.74589849
85MAP3K20.74147759
86EGFR0.73591523
87PINK10.73362203
88MAP2K60.73232396
89MAP3K130.73148062
90ABL20.71799708
91LCK0.71672019
92ILK0.69176064
93MAP2K40.67290920
94NTRK30.66923624
95PKN10.66922604
96CAMKK10.66023761
97OXSR10.64809419
98LIMK10.64786823
99SIK10.64623109
100SGK20.63491771
101FYN0.63438095
102PRKCQ0.62921971
103MELK0.62795524
104ABL10.62317434
105BCKDK0.62228492
106IKBKE0.61001178
107CAMK2G0.60313816
108GSK3A0.59671805
109PDK10.59461134
110PRKCI0.59170597
111MARK30.58359497
112DYRK1A0.56705088
113PRKCZ0.56253735
114PIK3CG0.55779864
115DAPK20.55082878
116DDR20.54942533
117PRKCE0.54179774
118CSNK1G20.54034890
119TRIM280.53353311
120ROCK20.52328212
121PDPK10.52309033
122BCR0.51843390
123PRKD10.51778679
124MAP3K120.51306281
125DYRK30.51139071
126PIM10.50577064
127CHUK0.50550677
128MAP2K20.50061528
129STK160.49689493
130MAP3K60.49367977
131PHKG20.49279866
132PHKG10.49279866
133PLK20.49054471
134CSNK1A1L0.48104992
135FES0.47626817
136PRKACA0.46251093
137DYRK20.45661414
138IRAK40.45366756
139STK390.45358070
140CAMK10.44650887
141IGF1R0.43446782
142FGR0.42736910
143TSSK60.42711700
144SGK10.42241276
145PRKG10.41992904
146CAMK2A0.41866862
147TTK0.41216293
148IKBKB0.40992163
149CAMK40.40956072
150STK38L0.40938043
151EPHA30.40455449
152PDK20.39010015
153PRKCG0.38794267
154FER0.37919211
155PRKAA20.37858049
156CSNK1G30.37774833
157PRKCD0.37127705
158EIF2AK20.36645470
159CSNK1G10.36424565
160MYLK0.36284213
161SGK4940.36185385
162SGK2230.36185385
163PLK30.36069521
164WNK10.35888996
165MARK10.35815328
166MINK10.35556527
167BMPR20.34410264
168PRKCA0.34250174

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.06147506
2Nitrogen metabolism_Homo sapiens_hsa009103.05334866
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.87163947
4Steroid biosynthesis_Homo sapiens_hsa001002.71929680
5Linoleic acid metabolism_Homo sapiens_hsa005912.63384723
6Huntingtons disease_Homo sapiens_hsa050162.55229030
7Phototransduction_Homo sapiens_hsa047442.54897144
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.36899117
9Complement and coagulation cascades_Homo sapiens_hsa046102.21482999
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.20629374
11Leishmaniasis_Homo sapiens_hsa051402.19276178
12Fatty acid elongation_Homo sapiens_hsa000622.00419419
13Primary bile acid biosynthesis_Homo sapiens_hsa001201.93726412
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.93129560
15Malaria_Homo sapiens_hsa051441.81966333
16Pertussis_Homo sapiens_hsa051331.77061386
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.72742350
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.70421288
19Leukocyte transendothelial migration_Homo sapiens_hsa046701.67369412
20Peroxisome_Homo sapiens_hsa041461.67254122
21Osteoclast differentiation_Homo sapiens_hsa043801.64512578
22Nicotine addiction_Homo sapiens_hsa050331.63599667
23Chemical carcinogenesis_Homo sapiens_hsa052041.63377549
24Histidine metabolism_Homo sapiens_hsa003401.61313194
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.61246573
26Oxidative phosphorylation_Homo sapiens_hsa001901.60550210
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.58625724
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.58559158
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.58492531
30Phagosome_Homo sapiens_hsa041451.58380575
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.58318440
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.52296091
33Basal transcription factors_Homo sapiens_hsa030221.51285989
34Fatty acid degradation_Homo sapiens_hsa000711.49744011
35Olfactory transduction_Homo sapiens_hsa047401.49206847
36Collecting duct acid secretion_Homo sapiens_hsa049661.47924365
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.43469703
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43269043
39Arginine biosynthesis_Homo sapiens_hsa002201.36466348
40Taste transduction_Homo sapiens_hsa047421.34867425
41Arachidonic acid metabolism_Homo sapiens_hsa005901.31202622
42beta-Alanine metabolism_Homo sapiens_hsa004101.30746463
43B cell receptor signaling pathway_Homo sapiens_hsa046621.29529562
44Sulfur metabolism_Homo sapiens_hsa009201.28862158
45Glutathione metabolism_Homo sapiens_hsa004801.28534808
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25986250
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.25558215
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.23828538
49Phenylalanine metabolism_Homo sapiens_hsa003601.21901487
50Fatty acid metabolism_Homo sapiens_hsa012121.21719883
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20680418
52Tryptophan metabolism_Homo sapiens_hsa003801.17822980
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.16483857
54Shigellosis_Homo sapiens_hsa051311.15161128
55Rheumatoid arthritis_Homo sapiens_hsa053231.13815855
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13122293
57Serotonergic synapse_Homo sapiens_hsa047261.10537390
58Lysosome_Homo sapiens_hsa041421.08947835
59Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08393500
60Salivary secretion_Homo sapiens_hsa049701.06609513
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05832833
62Parkinsons disease_Homo sapiens_hsa050121.04487797
63SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01928703
64Tuberculosis_Homo sapiens_hsa051521.01035504
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99870418
66Butanoate metabolism_Homo sapiens_hsa006500.99445780
67Salmonella infection_Homo sapiens_hsa051320.99024125
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.98984950
69Circadian rhythm_Homo sapiens_hsa047100.98816882
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98697128
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96939856
72Fanconi anemia pathway_Homo sapiens_hsa034600.95193479
73Legionellosis_Homo sapiens_hsa051340.93429504
74Homologous recombination_Homo sapiens_hsa034400.92979975
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92949863
76RNA polymerase_Homo sapiens_hsa030200.90348755
77Protein export_Homo sapiens_hsa030600.90191561
78Hepatitis C_Homo sapiens_hsa051600.90046326
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89613059
80Hematopoietic cell lineage_Homo sapiens_hsa046400.89325301
81Toxoplasmosis_Homo sapiens_hsa051450.88890426
82Ether lipid metabolism_Homo sapiens_hsa005650.88434193
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86357907
84Fatty acid biosynthesis_Homo sapiens_hsa000610.86327604
85Regulation of autophagy_Homo sapiens_hsa041400.86007147
86T cell receptor signaling pathway_Homo sapiens_hsa046600.82233324
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80792756
88ABC transporters_Homo sapiens_hsa020100.80570320
89Alzheimers disease_Homo sapiens_hsa050100.80549430
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78918740
91Morphine addiction_Homo sapiens_hsa050320.78807932
92Pentose phosphate pathway_Homo sapiens_hsa000300.78237553
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77723913
94Calcium signaling pathway_Homo sapiens_hsa040200.76730497
95African trypanosomiasis_Homo sapiens_hsa051430.76637429
96Platelet activation_Homo sapiens_hsa046110.74292132
97PPAR signaling pathway_Homo sapiens_hsa033200.74188618
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73389393
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.73179220
100Caffeine metabolism_Homo sapiens_hsa002320.72980432
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72980231
102Sphingolipid metabolism_Homo sapiens_hsa006000.72206346
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71045249
104Chemokine signaling pathway_Homo sapiens_hsa040620.65006585
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.64102012
106Cardiac muscle contraction_Homo sapiens_hsa042600.62915443
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62045018
108TNF signaling pathway_Homo sapiens_hsa046680.61632641
109Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61474293
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60547354
111Insulin secretion_Homo sapiens_hsa049110.60364174
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59782930
113Retinol metabolism_Homo sapiens_hsa008300.58140423
114Type I diabetes mellitus_Homo sapiens_hsa049400.57411660
115Purine metabolism_Homo sapiens_hsa002300.56472971
116Glycerolipid metabolism_Homo sapiens_hsa005610.56086510
117Glutamatergic synapse_Homo sapiens_hsa047240.56013941
118Dorso-ventral axis formation_Homo sapiens_hsa043200.55714410
119Tyrosine metabolism_Homo sapiens_hsa003500.55693641
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.55379819
121Tight junction_Homo sapiens_hsa045300.54205535
122Amoebiasis_Homo sapiens_hsa051460.53222595
123Circadian entrainment_Homo sapiens_hsa047130.52744114
124Measles_Homo sapiens_hsa051620.52244490
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51782663
126GABAergic synapse_Homo sapiens_hsa047270.51000536
127Vibrio cholerae infection_Homo sapiens_hsa051100.50388553
128Pancreatic cancer_Homo sapiens_hsa052120.48368260
129Cocaine addiction_Homo sapiens_hsa050300.47906158
130Ovarian steroidogenesis_Homo sapiens_hsa049130.47904327
131Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47623251
132Starch and sucrose metabolism_Homo sapiens_hsa005000.45611814
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.45523426
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.44493968
135Viral myocarditis_Homo sapiens_hsa054160.43204726
136Chronic myeloid leukemia_Homo sapiens_hsa052200.43054885
137Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42316065
138Long-term depression_Homo sapiens_hsa047300.41698073
139Metabolic pathways_Homo sapiens_hsa011000.41592138
140RNA degradation_Homo sapiens_hsa030180.41191522
141Hepatitis B_Homo sapiens_hsa051610.41027895
142Jak-STAT signaling pathway_Homo sapiens_hsa046300.40990919
143Renin secretion_Homo sapiens_hsa049240.40581818
144Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40493673
145Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40387354
146cAMP signaling pathway_Homo sapiens_hsa040240.39229524
147Amphetamine addiction_Homo sapiens_hsa050310.39134900
148Primary immunodeficiency_Homo sapiens_hsa053400.39119199
149Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38712537
150Drug metabolism - other enzymes_Homo sapiens_hsa009830.38699730
151Rap1 signaling pathway_Homo sapiens_hsa040150.38648034
152Propanoate metabolism_Homo sapiens_hsa006400.38326251
153Dopaminergic synapse_Homo sapiens_hsa047280.36458962
154VEGF signaling pathway_Homo sapiens_hsa043700.36119840
155Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34188612
156Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34081967
157Proteoglycans in cancer_Homo sapiens_hsa052050.33682850
158Axon guidance_Homo sapiens_hsa043600.32016154
159Influenza A_Homo sapiens_hsa051640.31714673
160Bile secretion_Homo sapiens_hsa049760.30306282
161Adipocytokine signaling pathway_Homo sapiens_hsa049200.29459784
162Selenocompound metabolism_Homo sapiens_hsa004500.29057162
163Glycosaminoglycan degradation_Homo sapiens_hsa005310.26071937

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