

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 6.20281186 |
| 2 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 6.02738078 |
| 3 | vocalization behavior (GO:0071625) | 5.99896832 |
| 4 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.71159054 |
| 5 | sodium ion export (GO:0071436) | 5.64139455 |
| 6 | synaptic vesicle exocytosis (GO:0016079) | 5.48492267 |
| 7 | locomotory exploration behavior (GO:0035641) | 5.44082279 |
| 8 | regulation of glutamate receptor signaling pathway (GO:1900449) | 5.26488184 |
| 9 | protein localization to synapse (GO:0035418) | 5.25059420 |
| 10 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.21072414 |
| 11 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 5.16844811 |
| 12 | synaptic vesicle maturation (GO:0016188) | 5.16232799 |
| 13 | glutamate secretion (GO:0014047) | 4.95409599 |
| 14 | neuron cell-cell adhesion (GO:0007158) | 4.94880618 |
| 15 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.75707399 |
| 16 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 4.71470719 |
| 17 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.69364128 |
| 18 | glutamate receptor signaling pathway (GO:0007215) | 4.68746629 |
| 19 | regulation of neuronal synaptic plasticity (GO:0048168) | 4.57929670 |
| 20 | neuronal action potential propagation (GO:0019227) | 4.57702664 |
| 21 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 4.55762496 |
| 22 | exploration behavior (GO:0035640) | 4.54946104 |
| 23 | L-amino acid import (GO:0043092) | 4.50328947 |
| 24 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 4.49672573 |
| 25 | synaptic transmission, glutamatergic (GO:0035249) | 4.45160557 |
| 26 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.44821608 |
| 27 | neuron-neuron synaptic transmission (GO:0007270) | 4.42955799 |
| 28 | neurotransmitter secretion (GO:0007269) | 4.33210797 |
| 29 | dendritic spine morphogenesis (GO:0060997) | 4.26798804 |
| 30 | regulation of synapse structural plasticity (GO:0051823) | 4.24943797 |
| 31 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 4.24514063 |
| 32 | regulation of synaptic vesicle transport (GO:1902803) | 4.23738510 |
| 33 | layer formation in cerebral cortex (GO:0021819) | 4.22854994 |
| 34 | cerebellar granule cell differentiation (GO:0021707) | 4.12584483 |
| 35 | regulation of dendritic spine morphogenesis (GO:0061001) | 4.10133522 |
| 36 | long-term memory (GO:0007616) | 4.07344113 |
| 37 | positive regulation of membrane potential (GO:0045838) | 4.05639746 |
| 38 | negative regulation of dendrite morphogenesis (GO:0050774) | 4.04787005 |
| 39 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 4.03069258 |
| 40 | regulation of postsynaptic membrane potential (GO:0060078) | 4.01516528 |
| 41 | amino acid import (GO:0043090) | 3.99105115 |
| 42 | cell communication by electrical coupling (GO:0010644) | 3.97343042 |
| 43 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.89780291 |
| 44 | neuron recognition (GO:0008038) | 3.85739084 |
| 45 | response to histamine (GO:0034776) | 3.83951769 |
| 46 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.83611198 |
| 47 | gamma-aminobutyric acid transport (GO:0015812) | 3.82017973 |
| 48 | regulation of synaptic plasticity (GO:0048167) | 3.81277556 |
| 49 | positive regulation of synapse maturation (GO:0090129) | 3.79218067 |
| 50 | long-term synaptic potentiation (GO:0060291) | 3.75813369 |
| 51 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.75511428 |
| 52 | postsynaptic membrane organization (GO:0001941) | 3.68459891 |
| 53 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.66651220 |
| 54 | membrane depolarization during action potential (GO:0086010) | 3.65685303 |
| 55 | presynaptic membrane assembly (GO:0097105) | 3.64096914 |
| 56 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.62920837 |
| 57 | behavioral fear response (GO:0001662) | 3.62721253 |
| 58 | behavioral defense response (GO:0002209) | 3.62721253 |
| 59 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.61930731 |
| 60 | regulation of glutamate secretion (GO:0014048) | 3.60751632 |
| 61 | transmission of nerve impulse (GO:0019226) | 3.58782680 |
| 62 | auditory behavior (GO:0031223) | 3.55417657 |
| 63 | neurotransmitter transport (GO:0006836) | 3.50819712 |
| 64 | regulation of dendritic spine development (GO:0060998) | 3.50498798 |
| 65 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.49033448 |
| 66 | cellular sodium ion homeostasis (GO:0006883) | 3.48298385 |
| 67 | regulation of female receptivity (GO:0045924) | 3.47064240 |
| 68 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.46838137 |
| 69 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.44782325 |
| 70 | proline transport (GO:0015824) | 3.43585798 |
| 71 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.43578482 |
| 72 | neuromuscular process controlling balance (GO:0050885) | 3.43281727 |
| 73 | potassium ion homeostasis (GO:0055075) | 3.41479633 |
| 74 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.41068080 |
| 75 | fear response (GO:0042596) | 3.38601425 |
| 76 | presynaptic membrane organization (GO:0097090) | 3.38070423 |
| 77 | synaptic vesicle endocytosis (GO:0048488) | 3.37419935 |
| 78 | prepulse inhibition (GO:0060134) | 3.36299878 |
| 79 | positive regulation of dendritic spine development (GO:0060999) | 3.36222893 |
| 80 | axonal fasciculation (GO:0007413) | 3.36010583 |
| 81 | regulation of neurotransmitter secretion (GO:0046928) | 3.35404031 |
| 82 | activation of protein kinase A activity (GO:0034199) | 3.33862276 |
| 83 | behavioral response to cocaine (GO:0048148) | 3.33787921 |
| 84 | positive regulation of neurotransmitter transport (GO:0051590) | 3.32576856 |
| 85 | regulation of vesicle fusion (GO:0031338) | 3.32395239 |
| 86 | membrane depolarization (GO:0051899) | 3.31784074 |
| 87 | serotonin metabolic process (GO:0042428) | 3.31513772 |
| 88 | regulation of neurotransmitter levels (GO:0001505) | 3.30219523 |
| 89 | learning (GO:0007612) | 3.29695477 |
| 90 | response to auditory stimulus (GO:0010996) | 3.29331219 |
| 91 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.29206142 |
| 92 | membrane hyperpolarization (GO:0060081) | 3.28664049 |
| 93 | regulation of ARF protein signal transduction (GO:0032012) | 3.27284705 |
| 94 | cellular potassium ion homeostasis (GO:0030007) | 3.26119954 |
| 95 | dendritic spine organization (GO:0097061) | 3.25150486 |
| 96 | startle response (GO:0001964) | 3.21008260 |
| 97 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.18323152 |
| 98 | female mating behavior (GO:0060180) | 3.17956413 |
| 99 | mating behavior (GO:0007617) | 3.15440793 |
| 100 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.11958825 |
| 101 | synapse assembly (GO:0007416) | 3.11909022 |
| 102 | regulation of neurotransmitter transport (GO:0051588) | 3.11724961 |
| 103 | cell communication involved in cardiac conduction (GO:0086065) | 3.11670249 |
| 104 | acidic amino acid transport (GO:0015800) | 3.09909464 |
| 105 | positive regulation of synaptic transmission (GO:0050806) | 3.09215082 |
| 106 | potassium ion import (GO:0010107) | 3.08447739 |
| 107 | vesicle transport along microtubule (GO:0047496) | 3.07933847 |
| 108 | * synaptic transmission (GO:0007268) | 3.07784881 |
| 109 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 3.07197047 |
| 110 | neuromuscular synaptic transmission (GO:0007274) | 3.06221861 |
| 111 | regulation of synaptic transmission (GO:0050804) | 3.06147988 |
| 112 | negative regulation of amino acid transport (GO:0051956) | 3.04527850 |
| 113 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.04083710 |
| 114 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.03616934 |
| 115 | regulation of synapse maturation (GO:0090128) | 3.03230337 |
| 116 | intraspecies interaction between organisms (GO:0051703) | 3.02940145 |
| 117 | social behavior (GO:0035176) | 3.02940145 |
| 118 | striatum development (GO:0021756) | 3.02283839 |
| 119 | detection of calcium ion (GO:0005513) | 3.01004366 |
| 120 | synaptic transmission, dopaminergic (GO:0001963) | 3.00510784 |
| 121 | mechanosensory behavior (GO:0007638) | 2.99969307 |
| 122 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.99652261 |
| 123 | neuronal ion channel clustering (GO:0045161) | 2.99368809 |
| 124 | neuromuscular process (GO:0050905) | 2.97355922 |
| 125 | retinal cone cell development (GO:0046549) | 2.94168917 |
| 126 | phosphorelay signal transduction system (GO:0000160) | 2.90880188 |
| 127 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 2.90862113 |
| 128 | primary amino compound metabolic process (GO:1901160) | 2.86525996 |
| 129 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 2.84305326 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.29186690 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.78517552 |
| 3 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.27026677 |
| 4 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.22929412 |
| 5 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.21735285 |
| 6 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.77102682 |
| 7 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 2.75572442 |
| 8 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.75572016 |
| 9 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.75572016 |
| 10 | * RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.71686689 |
| 11 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.69655289 |
| 12 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.63109247 |
| 13 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.57126230 |
| 14 | * MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.56519460 |
| 15 | * SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.56144483 |
| 16 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.54239319 |
| 17 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.32969504 |
| 18 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.32382739 |
| 19 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.31504202 |
| 20 | * SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.30112362 |
| 21 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.26786917 |
| 22 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.24733754 |
| 23 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.20618137 |
| 24 | * REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.18645676 |
| 25 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.06290301 |
| 26 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.00490753 |
| 27 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.96366703 |
| 28 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.90309561 |
| 29 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.88208632 |
| 30 | * MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.81443902 |
| 31 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.78375540 |
| 32 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.75843920 |
| 33 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.73257639 |
| 34 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.69385235 |
| 35 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.67743586 |
| 36 | * ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.65679841 |
| 37 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.65414230 |
| 38 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.53396638 |
| 39 | P300_19829295_ChIP-Seq_ESCs_Human | 1.52213072 |
| 40 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.46418865 |
| 41 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.42307601 |
| 42 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.41780949 |
| 43 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.38989675 |
| 44 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.35012316 |
| 45 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.34742332 |
| 46 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.34536614 |
| 47 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.34175157 |
| 48 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.33474824 |
| 49 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.31002385 |
| 50 | * RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.29676135 |
| 51 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.29246014 |
| 52 | * OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.28566191 |
| 53 | * TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.28302659 |
| 54 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.28223783 |
| 55 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.28161214 |
| 56 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.27682573 |
| 57 | * AR_25329375_ChIP-Seq_VCAP_Human | 1.27312694 |
| 58 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.27294105 |
| 59 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.27175011 |
| 60 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.26347012 |
| 61 | * STAT3_23295773_ChIP-Seq_U87_Human | 1.22133350 |
| 62 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.21998073 |
| 63 | * SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.20771160 |
| 64 | * RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.19488263 |
| 65 | FUS_26573619_Chip-Seq_HEK293_Human | 1.17864859 |
| 66 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.17489721 |
| 67 | AR_19668381_ChIP-Seq_PC3_Human | 1.17130962 |
| 68 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.16768715 |
| 69 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.15214606 |
| 70 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.13198112 |
| 71 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.12000460 |
| 72 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.11104023 |
| 73 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.10214643 |
| 74 | TCF4_23295773_ChIP-Seq_U87_Human | 1.09912027 |
| 75 | * EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.09674708 |
| 76 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.09385957 |
| 77 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.09017120 |
| 78 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.08597447 |
| 79 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.07140696 |
| 80 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.06787970 |
| 81 | KDM2B_26808549_Chip-Seq_K562_Human | 1.06419102 |
| 82 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.06327762 |
| 83 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.05070715 |
| 84 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.04925364 |
| 85 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.03052866 |
| 86 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.02775752 |
| 87 | VDR_22108803_ChIP-Seq_LS180_Human | 1.02717296 |
| 88 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.02551221 |
| 89 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.01763119 |
| 90 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.01524223 |
| 91 | * RUNX2_22187159_ChIP-Seq_PCA_Human | 0.99809633 |
| 92 | * AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.99675775 |
| 93 | JUN_21703547_ChIP-Seq_K562_Human | 0.99255447 |
| 94 | * ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.98676061 |
| 95 | * CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 0.98268675 |
| 96 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.97713825 |
| 97 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 0.97164905 |
| 98 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.96893638 |
| 99 | TP53_16413492_ChIP-PET_HCT116_Human | 0.96708055 |
| 100 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.96660283 |
| 101 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.96660283 |
| 102 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.95667792 |
| 103 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.95196811 |
| 104 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.94493876 |
| 105 | * WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 0.93836499 |
| 106 | KDM2B_26808549_Chip-Seq_REH_Human | 0.91850424 |
| 107 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 0.91808335 |
| 108 | TP53_18474530_ChIP-ChIP_U2OS_Human | 0.91620134 |
| 109 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.91074849 |
| 110 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.90285197 |
| 111 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.89993864 |
| 112 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 0.89622773 |
| 113 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.88687984 |
| 114 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.87169984 |
| 115 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.87031815 |
| 116 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.86654461 |
| 117 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.86047583 |
| 118 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.85820889 |
| 119 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.84782503 |
| 120 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.83995988 |
| 121 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.83593080 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 6.62374050 |
| 2 | MP0003880_abnormal_central_pattern | 5.41095340 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 4.34045615 |
| 4 | MP0009745_abnormal_behavioral_response | 3.71136054 |
| 5 | MP0004270_analgesia | 3.57507399 |
| 6 | MP0002063_abnormal_learning/memory/cond | 3.54831008 |
| 7 | MP0002822_catalepsy | 3.40349021 |
| 8 | MP0002064_seizures | 3.33428383 |
| 9 | MP0009046_muscle_twitch | 3.22698620 |
| 10 | MP0001968_abnormal_touch/_nociception | 3.14916487 |
| 11 | MP0002572_abnormal_emotion/affect_behav | 3.00384219 |
| 12 | MP0002272_abnormal_nervous_system | 2.72160041 |
| 13 | MP0001486_abnormal_startle_reflex | 2.68193034 |
| 14 | MP0005423_abnormal_somatic_nervous | 2.59022095 |
| 15 | MP0002736_abnormal_nociception_after | 2.55021928 |
| 16 | MP0002734_abnormal_mechanical_nocicepti | 2.50377140 |
| 17 | MP0001501_abnormal_sleep_pattern | 2.49594674 |
| 18 | MP0001440_abnormal_grooming_behavior | 2.21492142 |
| 19 | MP0002735_abnormal_chemical_nociception | 2.07754106 |
| 20 | MP0002067_abnormal_sensory_capabilities | 1.95101439 |
| 21 | MP0001970_abnormal_pain_threshold | 1.90177575 |
| 22 | MP0003329_amyloid_beta_deposits | 1.89449824 |
| 23 | MP0002733_abnormal_thermal_nociception | 1.87972225 |
| 24 | MP0009780_abnormal_chondrocyte_physiolo | 1.82972199 |
| 25 | MP0004924_abnormal_behavior | 1.81649316 |
| 26 | MP0005386_behavior/neurological_phenoty | 1.81649316 |
| 27 | MP0008438_abnormal_cutaneous_collagen | 1.80490722 |
| 28 | MP0002184_abnormal_innervation | 1.78501318 |
| 29 | MP0002557_abnormal_social/conspecific_i | 1.77255302 |
| 30 | MP0000778_abnormal_nervous_system | 1.76116820 |
| 31 | MP0008569_lethality_at_weaning | 1.75249426 |
| 32 | MP0003879_abnormal_hair_cell | 1.67600438 |
| 33 | MP0004811_abnormal_neuron_physiology | 1.66770835 |
| 34 | MP0006276_abnormal_autonomic_nervous | 1.64736572 |
| 35 | MP0001529_abnormal_vocalization | 1.63044110 |
| 36 | MP0005646_abnormal_pituitary_gland | 1.62393825 |
| 37 | MP0002909_abnormal_adrenal_gland | 1.61671795 |
| 38 | MP0001984_abnormal_olfaction | 1.48745435 |
| 39 | MP0000955_abnormal_spinal_cord | 1.46230668 |
| 40 | MP0002066_abnormal_motor_capabilities/c | 1.42114755 |
| 41 | MP0004142_abnormal_muscle_tone | 1.41685322 |
| 42 | MP0001958_emphysema | 1.40544557 |
| 43 | MP0001188_hyperpigmentation | 1.40421713 |
| 44 | MP0005503_abnormal_tendon_morphology | 1.38088920 |
| 45 | MP0002882_abnormal_neuron_morphology | 1.36381347 |
| 46 | MP0001905_abnormal_dopamine_level | 1.32346963 |
| 47 | MP0003633_abnormal_nervous_system | 1.31581031 |
| 48 | MP0004858_abnormal_nervous_system | 1.30686422 |
| 49 | MP0005645_abnormal_hypothalamus_physiol | 1.26992988 |
| 50 | MP0001502_abnormal_circadian_rhythm | 1.26181400 |
| 51 | MP0003787_abnormal_imprinting | 1.24965834 |
| 52 | MP0004885_abnormal_endolymph | 1.23442947 |
| 53 | MP0005409_darkened_coat_color | 1.14035500 |
| 54 | MP0001348_abnormal_lacrimal_gland | 1.11517781 |
| 55 | MP0003631_nervous_system_phenotype | 1.11480330 |
| 56 | MP0002152_abnormal_brain_morphology | 1.06561048 |
| 57 | MP0003122_maternal_imprinting | 1.05094045 |
| 58 | MP0002837_dystrophic_cardiac_calcinosis | 1.02693717 |
| 59 | MP0008874_decreased_physiological_sensi | 1.02385942 |
| 60 | MP0010386_abnormal_urinary_bladder | 1.01926546 |
| 61 | MP0001299_abnormal_eye_distance/ | 1.00518374 |
| 62 | MP0008872_abnormal_physiological_respon | 0.98867696 |
| 63 | MP0000751_myopathy | 0.97771008 |
| 64 | MP0000013_abnormal_adipose_tissue | 0.94683681 |
| 65 | MP0002229_neurodegeneration | 0.93356487 |
| 66 | MP0005551_abnormal_eye_electrophysiolog | 0.92805267 |
| 67 | MP0002069_abnormal_eating/drinking_beha | 0.92801504 |
| 68 | MP0005275_abnormal_skin_tensile | 0.92252924 |
| 69 | MP0004742_abnormal_vestibular_system | 0.90659134 |
| 70 | MP0004145_abnormal_muscle_electrophysio | 0.90546949 |
| 71 | MP0004085_abnormal_heartbeat | 0.89579105 |
| 72 | MP0003075_altered_response_to | 0.86379128 |
| 73 | MP0000604_amyloidosis | 0.86328521 |
| 74 | MP0001177_atelectasis | 0.85638231 |
| 75 | MP0003690_abnormal_glial_cell | 0.85041803 |
| 76 | MP0005535_abnormal_body_temperature | 0.84336572 |
| 77 | MP0001963_abnormal_hearing_physiology | 0.82888399 |
| 78 | MP0002295_abnormal_pulmonary_circulatio | 0.82819080 |
| 79 | MP0003705_abnormal_hypodermis_morpholog | 0.82778979 |
| 80 | MP0003634_abnormal_glial_cell | 0.80253129 |
| 81 | MP0000920_abnormal_myelination | 0.79455150 |
| 82 | MP0004484_altered_response_of | 0.77926432 |
| 83 | MP0001346_abnormal_lacrimal_gland | 0.76189944 |
| 84 | MP0008961_abnormal_basal_metabolism | 0.76096422 |
| 85 | MP0003632_abnormal_nervous_system | 0.75985018 |
| 86 | MP0005499_abnormal_olfactory_system | 0.75155252 |
| 87 | MP0005394_taste/olfaction_phenotype | 0.75155252 |
| 88 | MP0000534_abnormal_ureter_morphology | 0.75017234 |
| 89 | MP0004215_abnormal_myocardial_fiber | 0.73276964 |
| 90 | MP0002090_abnormal_vision | 0.72199128 |
| 91 | MP0002752_abnormal_somatic_nervous | 0.71954028 |
| 92 | MP0005623_abnormal_meninges_morphology | 0.71838010 |
| 93 | MP0000631_abnormal_neuroendocrine_gland | 0.69263072 |
| 94 | MP0002638_abnormal_pupillary_reflex | 0.67225409 |
| 95 | MP0002876_abnormal_thyroid_physiology | 0.66406772 |
| 96 | MP0001485_abnormal_pinna_reflex | 0.65036239 |
| 97 | MP0003279_aneurysm | 0.64763283 |
| 98 | MP0003123_paternal_imprinting | 0.63126246 |
| 99 | MP0003045_fibrosis | 0.61824755 |
| 100 | MP0005167_abnormal_blood-brain_barrier | 0.61371570 |
| 101 | MP0005388_respiratory_system_phenotype | 0.59280576 |
| 102 | MP0002133_abnormal_respiratory_system | 0.59280576 |
| 103 | MP0001664_abnormal_digestion | 0.58671253 |
| 104 | MP0004233_abnormal_muscle_weight | 0.56881379 |
| 105 | MP0005187_abnormal_penis_morphology | 0.56839507 |
| 106 | MP0004510_myositis | 0.56301314 |
| 107 | MP0003283_abnormal_digestive_organ | 0.56030907 |
| 108 | MP0000569_abnormal_digit_pigmentation | 0.55732541 |
| 109 | MP0001943_abnormal_respiration | 0.55560338 |
| 110 | MP0003137_abnormal_impulse_conducting | 0.55149619 |
| 111 | MP0004147_increased_porphyrin_level | 0.53292215 |
| 112 | MP0010768_mortality/aging | 0.52648883 |
| 113 | MP0010234_abnormal_vibrissa_follicle | 0.49246670 |
| 114 | MP0010769_abnormal_survival | 0.48772475 |
| 115 | MP0003861_abnormal_nervous_system | 0.48708963 |
| 116 | MP0003956_abnormal_body_size | 0.48406560 |
| 117 | MP0010770_preweaning_lethality | 0.48076898 |
| 118 | MP0002082_postnatal_lethality | 0.48076898 |
| 119 | MP0004130_abnormal_muscle_cell | 0.46835721 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 8.36799537 |
| 2 | Myokymia (HP:0002411) | 7.47912704 |
| 3 | Focal seizures (HP:0007359) | 6.13468661 |
| 4 | Visual hallucinations (HP:0002367) | 5.28120897 |
| 5 | Epileptic encephalopathy (HP:0200134) | 5.11754116 |
| 6 | Atonic seizures (HP:0010819) | 4.80090089 |
| 7 | Absence seizures (HP:0002121) | 4.41668888 |
| 8 | Febrile seizures (HP:0002373) | 4.37493998 |
| 9 | Hyperventilation (HP:0002883) | 4.20797498 |
| 10 | Progressive cerebellar ataxia (HP:0002073) | 4.19391541 |
| 11 | Generalized tonic-clonic seizures (HP:0002069) | 4.06664559 |
| 12 | Dialeptic seizures (HP:0011146) | 4.02221101 |
| 13 | Broad-based gait (HP:0002136) | 3.99807847 |
| 14 | Action tremor (HP:0002345) | 3.86379575 |
| 15 | Poor eye contact (HP:0000817) | 3.65038916 |
| 16 | Dysdiadochokinesis (HP:0002075) | 3.59512632 |
| 17 | Impaired vibration sensation in the lower limbs (HP:0002166) | 3.42447515 |
| 18 | Anxiety (HP:0000739) | 3.36339314 |
| 19 | Amblyopia (HP:0000646) | 3.35091294 |
| 20 | Gaze-evoked nystagmus (HP:0000640) | 3.31739924 |
| 21 | Abnormal social behavior (HP:0012433) | 3.31553125 |
| 22 | Impaired social interactions (HP:0000735) | 3.31553125 |
| 23 | Depression (HP:0000716) | 3.24747260 |
| 24 | Dysmetria (HP:0001310) | 3.24429902 |
| 25 | Supranuclear gaze palsy (HP:0000605) | 3.22984157 |
| 26 | Ankle clonus (HP:0011448) | 3.18563609 |
| 27 | Akinesia (HP:0002304) | 3.17215123 |
| 28 | Urinary bladder sphincter dysfunction (HP:0002839) | 3.16348253 |
| 29 | Obstructive sleep apnea (HP:0002870) | 3.08541373 |
| 30 | Truncal ataxia (HP:0002078) | 3.04779327 |
| 31 | Cerebral inclusion bodies (HP:0100314) | 2.98237968 |
| 32 | Abnormal eating behavior (HP:0100738) | 2.94425144 |
| 33 | Excessive salivation (HP:0003781) | 2.91982081 |
| 34 | Drooling (HP:0002307) | 2.91982081 |
| 35 | Postural instability (HP:0002172) | 2.89664219 |
| 36 | Progressive inability to walk (HP:0002505) | 2.88180212 |
| 37 | Mutism (HP:0002300) | 2.86520263 |
| 38 | Scanning speech (HP:0002168) | 2.84188446 |
| 39 | Papilledema (HP:0001085) | 2.78897030 |
| 40 | Torticollis (HP:0000473) | 2.74784176 |
| 41 | Urinary urgency (HP:0000012) | 2.73801122 |
| 42 | Neurofibrillary tangles (HP:0002185) | 2.72861212 |
| 43 | Termporal pattern (HP:0011008) | 2.69917354 |
| 44 | Insidious onset (HP:0003587) | 2.69917354 |
| 45 | Stereotypic behavior (HP:0000733) | 2.67677781 |
| 46 | Epileptiform EEG discharges (HP:0011182) | 2.64483113 |
| 47 | Spastic gait (HP:0002064) | 2.61088574 |
| 48 | Focal dystonia (HP:0004373) | 2.55144113 |
| 49 | Inability to walk (HP:0002540) | 2.54241925 |
| 50 | Impaired smooth pursuit (HP:0007772) | 2.50192995 |
| 51 | Abnormality of the lower motor neuron (HP:0002366) | 2.50052070 |
| 52 | EEG with generalized epileptiform discharges (HP:0011198) | 2.47330460 |
| 53 | Tetraplegia (HP:0002445) | 2.46511731 |
| 54 | Bradykinesia (HP:0002067) | 2.45840419 |
| 55 | Abnormality of the corticospinal tract (HP:0002492) | 2.45309967 |
| 56 | Protrusio acetabuli (HP:0003179) | 2.43450704 |
| 57 | Genetic anticipation (HP:0003743) | 2.37646431 |
| 58 | Intention tremor (HP:0002080) | 2.37250440 |
| 59 | Fetal akinesia sequence (HP:0001989) | 2.36599820 |
| 60 | Absent speech (HP:0001344) | 2.33084044 |
| 61 | Diplopia (HP:0000651) | 2.32548281 |
| 62 | Abnormality of binocular vision (HP:0011514) | 2.32548281 |
| 63 | Hypsarrhythmia (HP:0002521) | 2.30538331 |
| 64 | Annular pancreas (HP:0001734) | 2.30507383 |
| 65 | Hemiparesis (HP:0001269) | 2.30171385 |
| 66 | Impaired vibratory sensation (HP:0002495) | 2.29686429 |
| 67 | Rigidity (HP:0002063) | 2.28726842 |
| 68 | Craniofacial dystonia (HP:0012179) | 2.28402782 |
| 69 | Delusions (HP:0000746) | 2.25923399 |
| 70 | Generalized myoclonic seizures (HP:0002123) | 2.21390637 |
| 71 | Status epilepticus (HP:0002133) | 2.21276453 |
| 72 | Lower limb muscle weakness (HP:0007340) | 2.20302020 |
| 73 | Vascular tortuosity (HP:0004948) | 2.19962856 |
| 74 | Dysmetric saccades (HP:0000641) | 2.19038125 |
| 75 | Neuronal loss in central nervous system (HP:0002529) | 2.15910507 |
| 76 | Resting tremor (HP:0002322) | 2.14785784 |
| 77 | Morphological abnormality of the pyramidal tract (HP:0002062) | 2.12511676 |
| 78 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.09987301 |
| 79 | Mild short stature (HP:0003502) | 2.08688058 |
| 80 | Premature rupture of membranes (HP:0001788) | 2.07535996 |
| 81 | Limb dystonia (HP:0002451) | 2.06676741 |
| 82 | Aortic aneurysm (HP:0004942) | 2.05225551 |
| 83 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.04950630 |
| 84 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.04950630 |
| 85 | Hemiplegia (HP:0002301) | 2.02605032 |
| 86 | Lower limb amyotrophy (HP:0007210) | 2.02560588 |
| 87 | Incomplete penetrance (HP:0003829) | 2.01905359 |
| 88 | Blue irides (HP:0000635) | 2.00468591 |
| 89 | Ankyloglossia (HP:0010296) | 1.98779874 |
| 90 | Protruding tongue (HP:0010808) | 1.97309697 |
| 91 | Insomnia (HP:0100785) | 1.97216790 |
| 92 | Lower limb asymmetry (HP:0100559) | 1.97150172 |
| 93 | Abnormality of salivation (HP:0100755) | 1.97034143 |
| 94 | Polyphagia (HP:0002591) | 1.95071687 |
| 95 | Pheochromocytoma (HP:0002666) | 1.93978564 |
| 96 | Apathy (HP:0000741) | 1.93370839 |
| 97 | Amyotrophic lateral sclerosis (HP:0007354) | 1.93003903 |
| 98 | Megalencephaly (HP:0001355) | 1.92852360 |
| 99 | Diminished movement (HP:0002374) | 1.91123092 |
| 100 | Gait ataxia (HP:0002066) | 1.90067063 |
| 101 | Overgrowth (HP:0001548) | 1.89350416 |
| 102 | Psychosis (HP:0000709) | 1.88380412 |
| 103 | Sleep apnea (HP:0010535) | 1.88176890 |
| 104 | Arterial tortuosity (HP:0005116) | 1.86121872 |
| 105 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 1.84294826 |
| 106 | Inappropriate behavior (HP:0000719) | 1.84283243 |
| 107 | Pointed chin (HP:0000307) | 1.84110642 |
| 108 | Ventricular fibrillation (HP:0001663) | 1.83552247 |
| 109 | Abnormal EKG (HP:0003115) | 1.82329294 |
| 110 | Neonatal short-limb short stature (HP:0008921) | 1.81914720 |
| 111 | Gait imbalance (HP:0002141) | 1.81658400 |
| 112 | Hyperthyroidism (HP:0000836) | 1.81433584 |
| 113 | Agitation (HP:0000713) | 1.79614870 |
| 114 | Abnormality of saccadic eye movements (HP:0000570) | 1.77102339 |
| 115 | Bradycardia (HP:0001662) | 1.76743826 |
| 116 | Rapidly progressive (HP:0003678) | 1.76721077 |
| 117 | Hypoventilation (HP:0002791) | 1.74838094 |
| 118 | Specific learning disability (HP:0001328) | 1.72976375 |
| 119 | Clonus (HP:0002169) | 1.72280067 |
| 120 | Atrophic scars (HP:0001075) | 1.70561504 |
| 121 | Aplasia involving bones of the extremities (HP:0009825) | 1.69905669 |
| 122 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.69905669 |
| 123 | Aplasia of the phalanges of the hand (HP:0009802) | 1.69905669 |
| 124 | Bowel diverticulosis (HP:0005222) | 1.69356247 |
| 125 | Diminished motivation (HP:0000745) | 1.68007109 |
| 126 | Turricephaly (HP:0000262) | 1.66626159 |
| 127 | Wormian bones (HP:0002645) | 1.66033897 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHA4 | 5.45388469 |
| 2 | NTRK3 | 4.47832390 |
| 3 | MAP3K9 | 3.56241273 |
| 4 | MAP3K4 | 2.89691451 |
| 5 | CASK | 2.78786975 |
| 6 | MARK1 | 2.78538195 |
| 7 | RIPK4 | 2.71077584 |
| 8 | MINK1 | 2.65315161 |
| 9 | DAPK2 | 2.55226910 |
| 10 | MAP2K7 | 2.43241159 |
| 11 | MAP3K12 | 2.09957539 |
| 12 | KSR2 | 1.98599199 |
| 13 | NTRK2 | 1.96987550 |
| 14 | PAK6 | 1.94202609 |
| 15 | DAPK1 | 1.89115570 |
| 16 | NTRK1 | 1.83906360 |
| 17 | MAP2K4 | 1.76060103 |
| 18 | KSR1 | 1.75382987 |
| 19 | PRKD3 | 1.72202033 |
| 20 | SIK2 | 1.68263753 |
| 21 | PLK2 | 1.66097068 |
| 22 | CAMKK1 | 1.62318726 |
| 23 | CDK5 | 1.55093175 |
| 24 | TNIK | 1.50921580 |
| 25 | FES | 1.50615482 |
| 26 | ARAF | 1.44007540 |
| 27 | PRPF4B | 1.42330297 |
| 28 | GRK5 | 1.38430057 |
| 29 | CDK19 | 1.26494190 |
| 30 | MAP3K13 | 1.25994673 |
| 31 | PRKCG | 1.20201523 |
| 32 | RIPK1 | 1.20060823 |
| 33 | MAPK13 | 1.19980786 |
| 34 | PNCK | 1.16571824 |
| 35 | CAMK2A | 1.13721511 |
| 36 | PDGFRA | 1.13199112 |
| 37 | BMPR2 | 1.10602414 |
| 38 | STK38 | 1.08140167 |
| 39 | PTK2B | 1.06452085 |
| 40 | CAMKK2 | 1.04809979 |
| 41 | CAMK2B | 1.01699274 |
| 42 | MAP3K2 | 0.99911574 |
| 43 | DDR2 | 0.96821110 |
| 44 | TYRO3 | 0.93752546 |
| 45 | UHMK1 | 0.90412517 |
| 46 | CDK18 | 0.88039107 |
| 47 | CDK14 | 0.86460210 |
| 48 | STK11 | 0.84805284 |
| 49 | RAF1 | 0.83569145 |
| 50 | CDK15 | 0.83343919 |
| 51 | CAMK1 | 0.82920608 |
| 52 | OXSR1 | 0.82823830 |
| 53 | FGR | 0.78170388 |
| 54 | CAMK1G | 0.77969978 |
| 55 | SGK494 | 0.77802155 |
| 56 | SGK223 | 0.77802155 |
| 57 | MAPKAPK5 | 0.75525806 |
| 58 | CSNK1G2 | 0.73478306 |
| 59 | SGK1 | 0.71230912 |
| 60 | WNK1 | 0.71205677 |
| 61 | CDK11A | 0.71168343 |
| 62 | LATS2 | 0.71162479 |
| 63 | BCR | 0.70639858 |
| 64 | PHKG2 | 0.68676965 |
| 65 | PHKG1 | 0.68676965 |
| 66 | TNK2 | 0.65595166 |
| 67 | TAOK1 | 0.65289712 |
| 68 | PAK3 | 0.64824771 |
| 69 | PRKCH | 0.64410246 |
| 70 | CCNB1 | 0.64296030 |
| 71 | PINK1 | 0.63191833 |
| 72 | DYRK1A | 0.62639191 |
| 73 | SIK3 | 0.61126344 |
| 74 | FER | 0.60155361 |
| 75 | PRKCE | 0.59218298 |
| 76 | RET | 0.59122862 |
| 77 | PDK1 | 0.58650283 |
| 78 | CAMK2D | 0.58377556 |
| 79 | PDPK1 | 0.57795642 |
| 80 | MARK2 | 0.55837319 |
| 81 | SGK2 | 0.55551518 |
| 82 | PRKCZ | 0.54013288 |
| 83 | MYLK | 0.53895365 |
| 84 | NME1 | 0.52405047 |
| 85 | DAPK3 | 0.51966670 |
| 86 | RPS6KA3 | 0.49776668 |
| 87 | ROCK1 | 0.49182310 |
| 88 | FYN | 0.48310194 |
| 89 | LIMK1 | 0.47660560 |
| 90 | CAMK2G | 0.46848283 |
| 91 | MAP3K6 | 0.45016505 |
| 92 | PDGFRB | 0.44851743 |
| 93 | MAP3K1 | 0.44802244 |
| 94 | MAP2K1 | 0.42505436 |
| 95 | MAPK10 | 0.42445594 |
| 96 | ROCK2 | 0.41836455 |
| 97 | ALK | 0.41594176 |
| 98 | SGK3 | 0.40241756 |
| 99 | PKN1 | 0.39537654 |
| 100 | CAMK1D | 0.39192850 |
| 101 | PAK2 | 0.38287309 |
| 102 | NEK6 | 0.37841071 |
| 103 | SCYL2 | 0.37790430 |
| 104 | STK39 | 0.37224035 |
| 105 | PRKG1 | 0.36507445 |
| 106 | PRKCB | 0.35224838 |
| 107 | TESK1 | 0.34670472 |
| 108 | MOS | 0.34616481 |
| 109 | MAPK12 | 0.32108726 |
| 110 | PRKACA | 0.32014307 |
| 111 | PRKCA | 0.31295667 |
| 112 | CAMK4 | 0.31195033 |
| 113 | MUSK | 0.31170740 |
| 114 | AKT3 | 0.30799341 |
| 115 | CSNK1G3 | 0.28176134 |
| 116 | MAP3K7 | 0.28147997 |
| 117 | BRAF | 0.27322989 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 4.10653277 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.17823460 |
| 3 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.92150432 |
| 4 | Long-term potentiation_Homo sapiens_hsa04720 | 2.89652379 |
| 5 | Olfactory transduction_Homo sapiens_hsa04740 | 2.88805523 |
| 6 | GABAergic synapse_Homo sapiens_hsa04727 | 2.85372350 |
| 7 | Circadian entrainment_Homo sapiens_hsa04713 | 2.85356777 |
| 8 | Morphine addiction_Homo sapiens_hsa05032 | 2.75206754 |
| 9 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.75125680 |
| 10 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.66569117 |
| 11 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.26329305 |
| 12 | Salivary secretion_Homo sapiens_hsa04970 | 2.25943886 |
| 13 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.00057135 |
| 14 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.95150276 |
| 15 | Renin secretion_Homo sapiens_hsa04924 | 1.90779091 |
| 16 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.89827424 |
| 17 | Insulin secretion_Homo sapiens_hsa04911 | 1.89675011 |
| 18 | Taste transduction_Homo sapiens_hsa04742 | 1.88552807 |
| 19 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.87948805 |
| 20 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.85057618 |
| 21 | Cocaine addiction_Homo sapiens_hsa05030 | 1.84275923 |
| 22 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.77543504 |
| 23 | Long-term depression_Homo sapiens_hsa04730 | 1.76849708 |
| 24 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.73256182 |
| 25 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.69527154 |
| 26 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.64814793 |
| 27 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.44154717 |
| 28 | Gap junction_Homo sapiens_hsa04540 | 1.41257910 |
| 29 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.34882059 |
| 30 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.30828578 |
| 31 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.27785870 |
| 32 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.22652840 |
| 33 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.18791365 |
| 34 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.17428105 |
| 35 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.15305921 |
| 36 | Axon guidance_Homo sapiens_hsa04360 | 1.13631530 |
| 37 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.10107384 |
| 38 | Glioma_Homo sapiens_hsa05214 | 1.05746931 |
| 39 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.04394834 |
| 40 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.04118859 |
| 41 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.03379700 |
| 42 | Melanogenesis_Homo sapiens_hsa04916 | 1.00524101 |
| 43 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.99626669 |
| 44 | Phototransduction_Homo sapiens_hsa04744 | 0.98295771 |
| 45 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.96986441 |
| 46 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.94175515 |
| 47 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.92686233 |
| 48 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.90344550 |
| 49 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.88853247 |
| 50 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.82075986 |
| 51 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.78806755 |
| 52 | Alzheimers disease_Homo sapiens_hsa05010 | 0.77932750 |
| 53 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.75079631 |
| 54 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.72919312 |
| 55 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.71524360 |
| 56 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.71211234 |
| 57 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.69014863 |
| 58 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.68400063 |
| 59 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.67531866 |
| 60 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.66733903 |
| 61 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.66551362 |
| 62 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.66195413 |
| 63 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.63814751 |
| 64 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.61786885 |
| 65 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.60337750 |
| 66 | Alcoholism_Homo sapiens_hsa05034 | 0.60063131 |
| 67 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.57386318 |
| 68 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.56778377 |
| 69 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.56642989 |
| 70 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.54927582 |
| 71 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.54862739 |
| 72 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.53531680 |
| 73 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.52549131 |
| 74 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.51087546 |
| 75 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.51032480 |
| 76 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.50192682 |
| 77 | Focal adhesion_Homo sapiens_hsa04510 | 0.50189132 |
| 78 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.47775180 |
| 79 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.46079300 |
| 80 | Prion diseases_Homo sapiens_hsa05020 | 0.45852997 |
| 81 | Parkinsons disease_Homo sapiens_hsa05012 | 0.45560010 |
| 82 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.41545936 |
| 83 | Bile secretion_Homo sapiens_hsa04976 | 0.40032761 |
| 84 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.40013697 |
| 85 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.39811911 |
| 86 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.39513839 |
| 87 | Amoebiasis_Homo sapiens_hsa05146 | 0.39366973 |
| 88 | Mineral absorption_Homo sapiens_hsa04978 | 0.38889988 |
| 89 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.38368579 |
| 90 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.36171910 |
| 91 | Circadian rhythm_Homo sapiens_hsa04710 | 0.35182502 |
| 92 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.34285040 |
| 93 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.32600259 |
| 94 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.31778313 |
| 95 | Endocytosis_Homo sapiens_hsa04144 | 0.31778131 |
| 96 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.31347347 |
| 97 | Tight junction_Homo sapiens_hsa04530 | 0.30681141 |
| 98 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.30528021 |
| 99 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.30471738 |
| 100 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.30299870 |
| 101 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.30269491 |
| 102 | Huntingtons disease_Homo sapiens_hsa05016 | 0.29981964 |
| 103 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.29961122 |
| 104 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.29167624 |
| 105 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.28852357 |
| 106 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.28695444 |
| 107 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.28450473 |
| 108 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.28002604 |
| 109 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.27981999 |
| 110 | Platelet activation_Homo sapiens_hsa04611 | 0.27922655 |
| 111 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.27833169 |
| 112 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.27323638 |
| 113 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.27051380 |
| 114 | Endometrial cancer_Homo sapiens_hsa05213 | 0.26815127 |
| 115 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.26543734 |
| 116 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.24991473 |

