KCNS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. Alternatively spliced transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)8.33714287
2muscle filament sliding (GO:0030049)8.33714287
3sarcoplasmic reticulum calcium ion transport (GO:0070296)7.24655505
4actin-mediated cell contraction (GO:0070252)7.00066465
5skeletal muscle contraction (GO:0003009)6.71617847
6regulation of skeletal muscle contraction (GO:0014819)5.83717576
7NADH metabolic process (GO:0006734)5.82185931
8skeletal muscle fiber development (GO:0048741)5.36193318
9actin filament-based movement (GO:0030048)5.27680979
10response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.19987846
11response to muscle activity (GO:0014850)5.05329268
12neurofilament cytoskeleton organization (GO:0060052)4.87805048
13neuronal action potential propagation (GO:0019227)4.85670216
14sensory perception of smell (GO:0007608)4.77198741
15striated muscle contraction (GO:0006941)4.74420827
16myotube cell development (GO:0014904)4.72117475
17IMP metabolic process (GO:0046040)4.67020678
18synaptic vesicle exocytosis (GO:0016079)4.51171989
19plasma membrane repair (GO:0001778)4.48944462
20glutamate secretion (GO:0014047)4.47607339
21tricarboxylic acid cycle (GO:0006099)4.46362718
22sarcomere organization (GO:0045214)4.45106626
23myofibril assembly (GO:0030239)4.41811080
24regulation of relaxation of muscle (GO:1901077)4.38615436
25negative regulation of dendrite morphogenesis (GO:0050774)4.33230999
26succinate metabolic process (GO:0006105)4.32703036
27positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.18285336
28skeletal muscle adaptation (GO:0043501)4.15103592
29cell migration in hindbrain (GO:0021535)4.13990594
30creatine metabolic process (GO:0006600)4.08594194
31glycogen catabolic process (GO:0005980)4.06528120
32oxaloacetate metabolic process (GO:0006107)4.03829426
33response to inactivity (GO:0014854)3.99832948
34glycogen biosynthetic process (GO:0005978)3.96692451
35glucan biosynthetic process (GO:0009250)3.96692451
36calcium-mediated signaling using intracellular calcium source (GO:0035584)3.95214768
37muscle contraction (GO:0006936)3.92333089
38galactose catabolic process (GO:0019388)3.83441701
39detection of temperature stimulus (GO:0016048)3.80873921
40regulation of short-term neuronal synaptic plasticity (GO:0048172)3.80458951
41proline transport (GO:0015824)3.80318071
42glucan catabolic process (GO:0009251)3.75913132
43neuromuscular process controlling posture (GO:0050884)3.74755593
44activation of protein kinase A activity (GO:0034199)3.72211091
45muscle fiber development (GO:0048747)3.66428215
46chemical homeostasis within a tissue (GO:0048875)3.66321236
47vocalization behavior (GO:0071625)3.65787212
48regulation of acyl-CoA biosynthetic process (GO:0050812)3.65334058
49negative regulation of synaptic transmission, GABAergic (GO:0032229)3.62586161
50striatum development (GO:0021756)3.60990953
51IMP biosynthetic process (GO:0006188)3.60177522
52regulation of sodium ion transmembrane transporter activity (GO:2000649)3.59568143
53actomyosin structure organization (GO:0031032)3.57766245
54regulation of protein kinase A signaling (GO:0010738)3.57425241
55regulation of coenzyme metabolic process (GO:0051196)3.54486475
56regulation of cofactor metabolic process (GO:0051193)3.54486475
57energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.54247810
58ATP hydrolysis coupled proton transport (GO:0015991)3.54247810
59neuronal action potential (GO:0019228)3.52986911
60mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.51798875
61muscle cell fate commitment (GO:0042693)3.51414225
62gluconeogenesis (GO:0006094)3.49378979
63skeletal muscle tissue regeneration (GO:0043403)3.49075646
64mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.47740866
65positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.46818524
66cellular polysaccharide catabolic process (GO:0044247)3.45492389
67muscle system process (GO:0003012)3.45375771
68neurotransmitter secretion (GO:0007269)3.44610641
69regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.44420470
70transferrin transport (GO:0033572)3.44270561
71detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.43403037
72detection of temperature stimulus involved in sensory perception (GO:0050961)3.43403037
73cardiac myofibril assembly (GO:0055003)3.43384314
74skeletal muscle tissue development (GO:0007519)3.42933637
75neuron cell-cell adhesion (GO:0007158)3.41615488
76regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.40565331
77positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.40294870
78establishment of protein localization to mitochondrial membrane (GO:0090151)3.38261645
79cardiac muscle contraction (GO:0060048)3.37308277
80desmosome organization (GO:0002934)3.36056806
81surfactant homeostasis (GO:0043129)3.33132271
82ferric iron transport (GO:0015682)3.32614517
83trivalent inorganic cation transport (GO:0072512)3.32614517
84purine nucleotide salvage (GO:0032261)3.29847739
85respiratory electron transport chain (GO:0022904)3.29489357
86regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.27619938
87fructose metabolic process (GO:0006000)3.26939061
88regulation of synaptic vesicle exocytosis (GO:2000300)3.25992611
89hexose biosynthetic process (GO:0019319)3.25480393
90muscle atrophy (GO:0014889)3.24476856
91electron transport chain (GO:0022900)3.23921773
92membrane depolarization during action potential (GO:0086010)3.21780792
93regulation of cAMP-dependent protein kinase activity (GO:2000479)3.18737002
94gamma-aminobutyric acid transport (GO:0015812)3.18481216
95positive regulation of mitochondrial fission (GO:0090141)3.15861602
96protein complex localization (GO:0031503)3.15739222
97protein insertion into membrane (GO:0051205)3.12332661
98negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.10218183
99polysaccharide catabolic process (GO:0000272)3.10162478
100cullin deneddylation (GO:0010388)3.08019326
101cellular protein complex localization (GO:0034629)3.07845837
102glycogen metabolic process (GO:0005977)3.07551284
103striated muscle cell development (GO:0055002)3.06020337
104regulation of translational termination (GO:0006449)3.05923246
105synaptic vesicle maturation (GO:0016188)3.04571543
106paraxial mesoderm development (GO:0048339)3.01210119
107striated muscle adaptation (GO:0014888)2.99887960
108glucan metabolic process (GO:0044042)2.99506152
109cellular glucan metabolic process (GO:0006073)2.99506152
110negative regulation of microtubule polymerization (GO:0031115)2.97941873
111muscle cell cellular homeostasis (GO:0046716)2.97898339
112galactose metabolic process (GO:0006012)2.96284539
113mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.95316069
114CDP-diacylglycerol metabolic process (GO:0046341)2.95073158
115regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.92886146
116energy coupled proton transport, down electrochemical gradient (GO:0015985)2.92594406
117ATP synthesis coupled proton transport (GO:0015986)2.92594406
118protein-cofactor linkage (GO:0018065)2.92058229
119monosaccharide biosynthetic process (GO:0046364)2.91774265
1204-hydroxyproline metabolic process (GO:0019471)2.91245488
121sensory perception of chemical stimulus (GO:0007606)2.90925668
122myotube differentiation (GO:0014902)2.89892018
123chaperone-mediated protein transport (GO:0072321)2.89538475
124cerebellar Purkinje cell differentiation (GO:0021702)2.89333629
125muscle organ morphogenesis (GO:0048644)2.86468581
126negative regulation of homotypic cell-cell adhesion (GO:0034111)2.86308434
127negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.85290100
128regulation of sodium ion transmembrane transport (GO:1902305)2.85154785
129myoblast fusion (GO:0007520)2.84979216
130membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.84919450
131regulation of synaptic vesicle transport (GO:1902803)2.84169184
132negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.83566658
133striated muscle atrophy (GO:0014891)2.83125969
134protein localization to cilium (GO:0061512)2.82337556
135AMP metabolic process (GO:0046033)2.81098813
136negative regulation of dendrite development (GO:2000171)2.79903752
137positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.79874197
138neurotransmitter transport (GO:0006836)2.79308003
139regulation of synaptic transmission, dopaminergic (GO:0032225)2.78797626
140action potential (GO:0001508)2.77982632
141regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.77088997
142regulation of glycogen (starch) synthase activity (GO:2000465)2.75009683
143regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.74648143
144innervation (GO:0060384)2.72754361
145serotonin receptor signaling pathway (GO:0007210)2.72673459
146positive regulation of synapse maturation (GO:0090129)2.72451523
147dopamine transport (GO:0015872)2.72101066
148cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.71340991
149response to cocaine (GO:0042220)2.70841420
150folic acid-containing compound biosynthetic process (GO:0009396)2.70575443
151protein neddylation (GO:0045116)2.69832244
152regulation of cell communication by electrical coupling (GO:0010649)2.69691510
153cardiac muscle hypertrophy (GO:0003300)2.69527375
154regulation of neurotransmitter levels (GO:0001505)2.69467664
155muscle cell development (GO:0055001)2.69289788
156negative regulation of cell size (GO:0045792)2.68610666
157cardiac muscle cell development (GO:0055013)2.67036815
158polysaccharide biosynthetic process (GO:0000271)2.66009266
159regulation of actin filament-based movement (GO:1903115)2.65182149
160regulation of sulfur metabolic process (GO:0042762)2.64676970
161protein deneddylation (GO:0000338)2.64550331
162homocysteine metabolic process (GO:0050667)2.63470445
163positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.62962113
164inositol phosphate catabolic process (GO:0071545)2.62659421
165synaptic vesicle docking involved in exocytosis (GO:0016081)2.62586474
166cellular polysaccharide biosynthetic process (GO:0033692)2.62485971
167mating behavior (GO:0007617)2.61509911
168striated muscle hypertrophy (GO:0014897)2.59453295
169positive regulation of myotube differentiation (GO:0010831)2.58894251
170behavioral response to cocaine (GO:0048148)2.58885700
171focal adhesion assembly (GO:0048041)2.57441307
172cell-substrate adherens junction assembly (GO:0007045)2.57441307
173cellular carbohydrate biosynthetic process (GO:0034637)2.56820748
174regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.56774203
175regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.56774203
176L-serine metabolic process (GO:0006563)2.56762646
177adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.56615143
178positive regulation of sodium ion transport (GO:0010765)2.53276107
179CDP-diacylglycerol biosynthetic process (GO:0016024)2.52810449
180regulation of dopamine secretion (GO:0014059)2.52742258
181melanosome transport (GO:0032402)2.52480256
1822-oxoglutarate metabolic process (GO:0006103)2.51626067
183negative regulation of cation channel activity (GO:2001258)2.49260182
184establishment of mitochondrion localization (GO:0051654)2.47951443
185muscle organ development (GO:0007517)2.47894281
186muscle structure development (GO:0061061)2.47876244
187establishment of melanosome localization (GO:0032401)2.47747203
188detection of calcium ion (GO:0005513)2.47483335
189muscle adaptation (GO:0043500)2.46851066
190COPII vesicle coating (GO:0048208)2.46170294
191negative regulation of necroptotic process (GO:0060546)2.45951951
192muscle tissue morphogenesis (GO:0060415)2.44467063
193adult heart development (GO:0007512)2.44220853
194cardiac cell development (GO:0055006)2.42963621
195response to mercury ion (GO:0046689)2.42742972
196syncytium formation by plasma membrane fusion (GO:0000768)2.42033145
197adherens junction assembly (GO:0034333)2.41876388
198regulation of plasminogen activation (GO:0010755)2.39666922

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.61279605
2GBX2_23144817_ChIP-Seq_PC3_Human3.72266621
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.71333800
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.43587735
5ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.41732234
6TAF15_26573619_Chip-Seq_HEK293_Human3.33396216
7AR_21909140_ChIP-Seq_LNCAP_Human3.06545630
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.89633871
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.79349911
10* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.63930755
11CLOCK_20551151_ChIP-Seq_293T_Human2.57339851
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.54166915
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.49099394
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.39344776
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.38597082
16REST_21632747_ChIP-Seq_MESCs_Mouse2.29501523
17ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.19579800
18E2F7_22180533_ChIP-Seq_HELA_Human2.18087294
19KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.10482787
20* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.09435815
21* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.09435815
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.07058103
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06449233
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.04589570
25* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.02553305
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.01290849
27* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.00270810
28ZNF263_19887448_ChIP-Seq_K562_Human1.99675759
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.94596635
30* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92690356
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.91781167
32* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.89706187
33TBX20_22080862_ChIP-Seq_HEART_Mouse1.89624389
34TBX20_22328084_ChIP-Seq_HEART_Mouse1.89624389
35ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.86685693
36NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.85038238
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83834020
38NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.82577389
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77987051
40TP63_17297297_ChIP-ChIP_HaCaT_Human1.76687125
41RACK7_27058665_Chip-Seq_MCF-7_Human1.76389629
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.75140070
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.74937638
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.74802053
45* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.72635520
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.69206281
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66102476
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.65352535
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.64444735
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.64021424
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.63300495
52EP300_21415370_ChIP-Seq_HL-1_Mouse1.62269461
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.62253605
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61152569
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.60922040
56MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.59705413
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.59199648
58* SMAD4_21799915_ChIP-Seq_A2780_Human1.58225606
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.58120809
60* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.57892132
61BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.56208812
62FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55696702
63TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.55541606
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.53877464
65ZNF274_21170338_ChIP-Seq_K562_Hela1.51590120
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51101245
67NFIB_24661679_ChIP-Seq_LUNG_Mouse1.50590603
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50458286
69PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.49658843
70SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.48554296
71* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.47909588
72P300_19829295_ChIP-Seq_ESCs_Human1.47564215
73MYC_19079543_ChIP-ChIP_MESCs_Mouse1.47463353
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42524784
75GATA4_21415370_ChIP-Seq_HL-1_Mouse1.41599230
76RARB_27405468_Chip-Seq_BRAIN_Mouse1.40600486
77CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.40178336
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.39059095
79* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37141956
80ATF3_27146783_Chip-Seq_COLON_Human1.37055614
81CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.35760083
82MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35634670
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34939322
84SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.34165409
85SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.34165409
86GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33440865
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33028960
88NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29964460
89ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.26757346
90TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26686327
91P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26374209
92TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25663676
93AR_25329375_ChIP-Seq_VCAP_Human1.24738585
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24705948
95VDR_22108803_ChIP-Seq_LS180_Human1.24654562
96SOX2_27498859_Chip-Seq_STOMACH_Mouse1.23018077
97* RNF2_27304074_Chip-Seq_ESCs_Mouse1.22813807
98KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19305406
99KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19305406
100KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19305406
101OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19221819
102SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19090759
103MYC_18358816_ChIP-ChIP_MESCs_Mouse1.18779410
104TBX5_21415370_ChIP-Seq_HL-1_Mouse1.17987218
105NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.17909894
106KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.17554983
107GATA3_24758297_ChIP-Seq_MCF-7_Human1.17385184
108RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17285961
109* SOX2_21211035_ChIP-Seq_LN229_Gbm1.16892803
110* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16618533
111* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16217190
112FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.16085737
113E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15098038
114CHD1_26751641_Chip-Seq_LNCaP_Human1.14484943
115DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13915760
116AHR_22903824_ChIP-Seq_MCF-7_Human1.13469487
117RXR_22158963_ChIP-Seq_LIVER_Mouse1.12546768
118HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12153728
119CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11473531
120MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10887675
121THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10826730
122SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10780717
123PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10433543
124BCAT_22108803_ChIP-Seq_LS180_Human1.09416157
125* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09286536
126TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08927680
127SMAD3_21741376_ChIP-Seq_EPCs_Human1.07964131
128ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07163613
129STAT3_23295773_ChIP-Seq_U87_Human1.07051780
130EZH2_27294783_Chip-Seq_ESCs_Mouse1.06403408
131JUN_21703547_ChIP-Seq_K562_Human1.05778383
132STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.05592553
133CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03801256
134PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03464526
135NANOG_18692474_ChIP-Seq_MEFs_Mouse1.03421722
136MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03321726
137PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02427082
138SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01994860
139* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01827801
140ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01739299
141CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01560082
142HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00474833
143FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99782045
144* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99753415
145OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99541163
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99183546
147SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98850653
148CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98496542
149* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.98240897
150SOX17_20123909_ChIP-Seq_XEN_Mouse0.97976538
151SOX2_18692474_ChIP-Seq_MEFs_Mouse0.97643644
152EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97582232
153POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97422694
154NANOG_16153702_ChIP-ChIP_HESCs_Human0.97382475
155SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97069209
156TCF4_22108803_ChIP-Seq_LS180_Human0.96025947
157PPARA_22158963_ChIP-Seq_LIVER_Mouse0.94780513
158ARNT_22903824_ChIP-Seq_MCF-7_Human0.94206884
159JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.93571786
160* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93334739
161REST_19997604_ChIP-ChIP_NEURONS_Mouse0.91368662
162MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91243660
163PRDM14_20953172_ChIP-Seq_ESCs_Human0.90909290
164* RUNX2_22187159_ChIP-Seq_PCA_Human0.89222238
165RNF2_27304074_Chip-Seq_NSC_Mouse0.88726251
166SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87687974
167SMAD4_21741376_ChIP-Seq_EPCs_Human0.86822764
168POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85640931
169HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.83820076
170ESR2_21235772_ChIP-Seq_MCF-7_Human0.83731036
171* DROSHA_22980978_ChIP-Seq_HELA_Human0.83321030
172YY1_21170310_ChIP-Seq_MESCs_Mouse0.83298570
173* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.83062811
174CREB1_15753290_ChIP-ChIP_HEK293T_Human0.82917450
175SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82768946
176MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.82235996
177NANOG_19829295_ChIP-Seq_ESCs_Human0.81996889
178SOX2_19829295_ChIP-Seq_ESCs_Human0.81996889
179NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.81573198
180CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.81043250
181TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.79561258
182IGF1R_20145208_ChIP-Seq_DFB_Human0.78919651
183ESR1_20079471_ChIP-ChIP_T-47D_Human0.78825610
184ETS1_20019798_ChIP-Seq_JURKAT_Human0.78095233
185ER_23166858_ChIP-Seq_MCF-7_Human0.78082133

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000749_muscle_degeneration4.86821427
2MP0001984_abnormal_olfaction4.40988176
3MP0002735_abnormal_chemical_nociception4.03868504
4MP0003880_abnormal_central_pattern3.64815029
5MP0009046_muscle_twitch3.52346412
6MP0004859_abnormal_synaptic_plasticity3.41531910
7MP0006276_abnormal_autonomic_nervous3.23896691
8MP0004270_analgesia3.16150347
9MP0001986_abnormal_taste_sensitivity3.15643842
10MP0001968_abnormal_touch/_nociception3.11820765
11MP0004233_abnormal_muscle_weight3.09623194
12MP0002736_abnormal_nociception_after3.05613946
13MP0000759_abnormal_skeletal_muscle2.90269994
14MP0004087_abnormal_muscle_fiber2.79633841
15MP0005451_abnormal_body_composition2.77362789
16MP0002106_abnormal_muscle_physiology2.75995555
17MP0002269_muscular_atrophy2.75766657
18MP0000750_abnormal_muscle_regeneration2.68231315
19MP0003635_abnormal_synaptic_transmissio2.66883760
20MP0002734_abnormal_mechanical_nocicepti2.63328839
21MP0003705_abnormal_hypodermis_morpholog2.57635705
22MP0003941_abnormal_skin_development2.57633191
23MP0004858_abnormal_nervous_system2.51326187
24MP0005369_muscle_phenotype2.50897992
25MP0002733_abnormal_thermal_nociception2.47828738
26MP0001501_abnormal_sleep_pattern2.47640951
27MP0002272_abnormal_nervous_system2.46070563
28MP0002837_dystrophic_cardiac_calcinosis2.42773658
29MP0004084_abnormal_cardiac_muscle2.41878172
30MP0002064_seizures2.36969559
31MP0005330_cardiomyopathy2.35402548
32MP0001970_abnormal_pain_threshold2.26987890
33MP0002876_abnormal_thyroid_physiology2.26421547
34MP0009745_abnormal_behavioral_response2.23046413
35MP0000733_abnormal_muscle_development2.22064327
36MP0002108_abnormal_muscle_morphology2.18054442
37MP0000013_abnormal_adipose_tissue2.17097789
38MP0002184_abnormal_innervation2.11184391
39MP0010030_abnormal_orbit_morphology2.08583614
40MP0002063_abnormal_learning/memory/cond2.07952110
41MP0004147_increased_porphyrin_level2.06045084
42MP0005670_abnormal_white_adipose2.04661469
43MP0002572_abnormal_emotion/affect_behav1.97996689
44MP0002067_abnormal_sensory_capabilities1.95871664
45MP0003646_muscle_fatigue1.93673882
46MP0001486_abnormal_startle_reflex1.90345217
47MP0002972_abnormal_cardiac_muscle1.70592461
48MP0002909_abnormal_adrenal_gland1.67025260
49MP0003329_amyloid_beta_deposits1.56423212
50MP0004782_abnormal_surfactant_physiolog1.55228855
51MP0004130_abnormal_muscle_cell1.54675447
52MP0010234_abnormal_vibrissa_follicle1.51565115
53MP0000762_abnormal_tongue_morphology1.51371225
54MP0001440_abnormal_grooming_behavior1.39773063
55MP0004811_abnormal_neuron_physiology1.35428452
56MP0001905_abnormal_dopamine_level1.35386471
57MP0006036_abnormal_mitochondrial_physio1.34083574
58MP0010630_abnormal_cardiac_muscle1.33877896
59MP0002796_impaired_skin_barrier1.32708610
60MP0002332_abnormal_exercise_endurance1.32584652
61MP0003950_abnormal_plasma_membrane1.31711191
62MP0000751_myopathy1.30267512
63MP0010386_abnormal_urinary_bladder1.29883242
64MP0005386_behavior/neurological_phenoty1.28737936
65MP0004924_abnormal_behavior1.28737936
66MP0009672_abnormal_birth_weight1.27361810
67MP0003879_abnormal_hair_cell1.27289374
68MP0005535_abnormal_body_temperature1.25568459
69MP0006035_abnormal_mitochondrial_morpho1.24673731
70MP0001529_abnormal_vocalization1.21881291
71MP0005666_abnormal_adipose_tissue1.19950648
72MP0004484_altered_response_of1.19544847
73MP0000955_abnormal_spinal_cord1.17453706
74MP0001542_abnormal_bone_strength1.16220382
75MP0004272_abnormal_basement_membrane1.15323473
76MP0002557_abnormal_social/conspecific_i1.14357281
77MP0002066_abnormal_motor_capabilities/c1.13898938
78MP0008260_abnormal_autophagy1.13867992
79MP0003693_abnormal_embryo_hatching1.11304243
80MP0002882_abnormal_neuron_morphology1.10310499
81MP0001346_abnormal_lacrimal_gland1.09555023
82MP0008569_lethality_at_weaning1.06591501
83MP0004142_abnormal_muscle_tone1.04568477
84MP0004215_abnormal_myocardial_fiber1.04385720
85MP0003122_maternal_imprinting1.02814712
86MP0000579_abnormal_nail_morphology1.02596171
87MP0001963_abnormal_hearing_physiology1.02237253
88MP0005394_taste/olfaction_phenotype1.01262404
89MP0005499_abnormal_olfactory_system1.01262404
90MP0003806_abnormal_nucleotide_metabolis1.01002000
91MP0001188_hyperpigmentation1.00692183
92MP0010352_gastrointestinal_tract_polyps1.00132860
93MP0000537_abnormal_urethra_morphology0.96724210
94MP0001485_abnormal_pinna_reflex0.94928220
95MP0008872_abnormal_physiological_respon0.93036249
96MP0000778_abnormal_nervous_system0.90988069
97MP0002229_neurodegeneration0.90695586
98MP0002752_abnormal_somatic_nervous0.90286107
99MP0001544_abnormal_cardiovascular_syste0.90011058
100MP0005385_cardiovascular_system_phenoty0.90011058
101MP0005266_abnormal_metabolism0.87998986
102MP0004036_abnormal_muscle_relaxation0.87514368
103MP0005375_adipose_tissue_phenotype0.86993797
104MP0004185_abnormal_adipocyte_glucose0.86395281
105MP0004957_abnormal_blastocyst_morpholog0.86285978
106MP0002751_abnormal_autonomic_nervous0.86277812
107MP0001849_ear_inflammation0.86124702
108MP0003566_abnormal_cell_adhesion0.84866094
109MP0002127_abnormal_cardiovascular_syste0.83594042
110MP0009780_abnormal_chondrocyte_physiolo0.79727887
111MP0002877_abnormal_melanocyte_morpholog0.78600661
112MP0002160_abnormal_reproductive_system0.77732273
113MP0000003_abnormal_adipose_tissue0.77047007
114MP0009250_abnormal_appendicular_skeleto0.76599764
115MP0003123_paternal_imprinting0.76411807
116MP0005275_abnormal_skin_tensile0.76092332
117MP0004145_abnormal_muscle_electrophysio0.75653637
118MP0001730_embryonic_growth_arrest0.75460734
119MP0001661_extended_life_span0.75442072
120MP0002971_abnormal_brown_adipose0.73104381
121MP0005645_abnormal_hypothalamus_physiol0.72877998
122MP0002822_catalepsy0.72303988
123MP0000467_abnormal_esophagus_morphology0.72151744
124MP0002254_reproductive_system_inflammat0.70190876
125MP0000747_muscle_weakness0.69982845
126MP0005165_increased_susceptibility_to0.68773126
127MP0003631_nervous_system_phenotype0.68550991
128MP0003633_abnormal_nervous_system0.68445434
129MP0001727_abnormal_embryo_implantation0.67862558
130MP0002697_abnormal_eye_size0.67830386
131MP0002060_abnormal_skin_morphology0.67582273
132MP0003221_abnormal_cardiomyocyte_apopto0.67298450
133MP0001664_abnormal_digestion0.67054765
134MP0002896_abnormal_bone_mineralization0.66872119
135MP0002152_abnormal_brain_morphology0.66083792
136MP0001270_distended_abdomen0.65596585
137MP0008789_abnormal_olfactory_epithelium0.65453360
138MP0002069_abnormal_eating/drinking_beha0.65091033
139MP0005620_abnormal_muscle_contractility0.64481205
140MP0008438_abnormal_cutaneous_collagen0.64247953
141MP0004742_abnormal_vestibular_system0.64097037
142MP0002653_abnormal_ependyma_morphology0.63838419
143MP0000266_abnormal_heart_morphology0.63753312
144MP0008932_abnormal_embryonic_tissue0.63295815
145MP0003453_abnormal_keratinocyte_physiol0.63219793
146MP0008775_abnormal_heart_ventricle0.62722625
147MP0000678_abnormal_parathyroid_gland0.62316530
148MP0000604_amyloidosis0.61894235
149MP0003634_abnormal_glial_cell0.61756748
150MP0005501_abnormal_skin_physiology0.61606038
151MP0009697_abnormal_copulation0.60018177
152MP0006138_congestive_heart_failure0.59855114
153MP0004085_abnormal_heartbeat0.59356711
154MP0000566_synostosis0.58967728
155MP0000534_abnormal_ureter_morphology0.57997280
156MP0001299_abnormal_eye_distance/0.57974535
157MP0010678_abnormal_skin_adnexa0.57522990
158MP0005076_abnormal_cell_differentiation0.56998664
159MP0005332_abnormal_amino_acid0.56922819
160MP0001177_atelectasis0.55783516
161MP0008874_decreased_physiological_sensi0.55259262
162MP0001340_abnormal_eyelid_morphology0.52611274
163MP0003115_abnormal_respiratory_system0.52227038
164MP0000627_abnormal_mammary_gland0.52131304
165MP0004264_abnormal_extraembryonic_tissu0.50835216
166MP0004197_abnormal_fetal_growth/weight/0.50582956
167MP0009703_decreased_birth_body0.49858193
168MP0005083_abnormal_biliary_tract0.49206764
169MP0005023_abnormal_wound_healing0.48267390
170MP0004510_myositis0.48262336
171MP0002114_abnormal_axial_skeleton0.48172763

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)9.73029131
2Muscle fiber inclusion bodies (HP:0100299)9.67131979
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)9.28899390
4Type 1 muscle fiber predominance (HP:0003803)7.28346497
5Exercise-induced muscle cramps (HP:0003710)7.01369425
6Exercise-induced myalgia (HP:0003738)7.01174430
7Atonic seizures (HP:0010819)6.39755596
8Focal motor seizures (HP:0011153)6.28221961
9Myopathic facies (HP:0002058)5.77320118
10Myokymia (HP:0002411)5.24440512
11Febrile seizures (HP:0002373)5.18702279
12Pheochromocytoma (HP:0002666)5.09448825
13Muscle hypertrophy of the lower extremities (HP:0008968)4.98827753
14Distal arthrogryposis (HP:0005684)4.92177734
15Neuroendocrine neoplasm (HP:0100634)4.87305432
16EMG: myopathic abnormalities (HP:0003458)4.60571903
17Calf muscle hypertrophy (HP:0008981)4.34905460
18Muscle fiber splitting (HP:0003555)4.23706600
19Absence seizures (HP:0002121)4.21518266
20Centrally nucleated skeletal muscle fibers (HP:0003687)4.18825686
21Focal seizures (HP:0007359)4.18168761
22Rhabdomyolysis (HP:0003201)4.11594208
23Neck muscle weakness (HP:0000467)4.09882327
24Hyporeflexia of lower limbs (HP:0002600)4.07293840
25Limb dystonia (HP:0002451)4.07006262
26Distal lower limb muscle weakness (HP:0009053)4.06800748
27Round ear (HP:0100830)4.02715483
28Oligomenorrhea (HP:0000876)4.00781890
29Myoglobinuria (HP:0002913)4.00746573
30Rimmed vacuoles (HP:0003805)3.94817194
31Increased connective tissue (HP:0009025)3.90160143
32Abnormality of the left ventricular outflow tract (HP:0011103)3.86192843
33Subaortic stenosis (HP:0001682)3.86192843
34Abnormality of skeletal muscle fiber size (HP:0012084)3.83112604
35Abnormality of the calf musculature (HP:0001430)3.76912927
36Acute necrotizing encephalopathy (HP:0006965)3.73224639
37Abnormal mitochondria in muscle tissue (HP:0008316)3.66188663
38Calcaneovalgus deformity (HP:0001848)3.64444608
39Dialeptic seizures (HP:0011146)3.64303128
40Ulnar deviation of the wrist (HP:0003049)3.63624011
41Ulnar claw (HP:0001178)3.61099436
42Increased serum pyruvate (HP:0003542)3.59143674
43Abnormality of glycolysis (HP:0004366)3.59143674
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.49730570
45Abnormality of alanine metabolism (HP:0010916)3.49730570
46Hyperalaninemia (HP:0003348)3.49730570
47Muscle stiffness (HP:0003552)3.37794690
48Impaired pain sensation (HP:0007328)3.27813123
49Abnormality of pain sensation (HP:0010832)3.27813123
50Progressive macrocephaly (HP:0004481)3.23537288
51Deformed tarsal bones (HP:0008119)3.20406140
52Generalized tonic-clonic seizures (HP:0002069)3.18818676
53Neoplasm of the peripheral nervous system (HP:0100007)3.16656204
54Acute encephalopathy (HP:0006846)3.14477057
55Epileptic encephalopathy (HP:0200134)3.12990999
56Action tremor (HP:0002345)3.12401746
57Mildly elevated creatine phosphokinase (HP:0008180)3.06714457
58Progressive inability to walk (HP:0002505)3.06450397
59Increased variability in muscle fiber diameter (HP:0003557)3.06307313
60Mitochondrial inheritance (HP:0001427)3.00461093
61Distal lower limb amyotrophy (HP:0008944)2.94265939
62Difficulty running (HP:0009046)2.94114573
63Increased CSF lactate (HP:0002490)2.93538486
64Absent phalangeal crease (HP:0006109)2.91219860
65Hepatocellular necrosis (HP:0001404)2.76570680
66Areflexia of lower limbs (HP:0002522)2.74152013
67Abnormal eating behavior (HP:0100738)2.71833461
68Progressive muscle weakness (HP:0003323)2.71691331
69Progressive cerebellar ataxia (HP:0002073)2.65673970
70Visual hallucinations (HP:0002367)2.63829640
71Bulbar palsy (HP:0001283)2.63141718
72Spinal rigidity (HP:0003306)2.61298843
73Hypothermia (HP:0002045)2.59598448
74Limb-girdle muscle atrophy (HP:0003797)2.57045485
75Malignant hyperthermia (HP:0002047)2.56264461
76Failure to thrive in infancy (HP:0001531)2.52341877
77Asymmetric septal hypertrophy (HP:0001670)2.46706644
78Delusions (HP:0000746)2.45710206
79Delayed gross motor development (HP:0002194)2.44058003
80Lower limb amyotrophy (HP:0007210)2.43090400
81Shoulder girdle muscle weakness (HP:0003547)2.42003035
82Hepatic necrosis (HP:0002605)2.39152080
83Sudden death (HP:0001699)2.39015708
84Lactic acidosis (HP:0003128)2.35689571
85Hyperkalemia (HP:0002153)2.35002215
86Palpitations (HP:0001962)2.34898724
87Bundle branch block (HP:0011710)2.34679030
88Dilated cardiomyopathy (HP:0001644)2.34124241
89Myotonia (HP:0002486)2.34089600
90Abnormal finger flexion creases (HP:0006143)2.30072516
91Difficulty climbing stairs (HP:0003551)2.29249672
92Hyperventilation (HP:0002883)2.27546501
93Generalized muscle weakness (HP:0003324)2.26315290
94Popliteal pterygium (HP:0009756)2.23840173
95EMG: neuropathic changes (HP:0003445)2.22958992
96Cerebral edema (HP:0002181)2.22955826
97Weak cry (HP:0001612)2.22693478
98Dysautonomia (HP:0002459)2.22534550
99Termporal pattern (HP:0011008)2.21490006
100Insidious onset (HP:0003587)2.21490006
101Truncal ataxia (HP:0002078)2.21421650
102Frequent falls (HP:0002359)2.20446693
103Ventricular tachycardia (HP:0004756)2.18576783
104Scapular winging (HP:0003691)2.17723276
105Abnormality of the vocal cords (HP:0008777)2.17418223
106Hyperglycinuria (HP:0003108)2.17015221
107Emotional lability (HP:0000712)2.16793066
108Polyphagia (HP:0002591)2.16487877
109Abnormality of the calcaneus (HP:0008364)2.16285718
110Cerebral hemorrhage (HP:0001342)2.14035852
111Slender build (HP:0001533)2.10273118
112Long foot (HP:0001833)2.09838269
113Hyperglycinemia (HP:0002154)2.09498835
114Respiratory failure (HP:0002878)2.08811512
115Autoamputation (HP:0001218)2.08573512
116Retinal dysplasia (HP:0007973)2.07407456
117Pelvic girdle muscle weakness (HP:0003749)2.07148989
118Abnormality of the hip-girdle musculature (HP:0001445)2.05721526
119Abnormality of the musculature of the pelvis (HP:0001469)2.05721526
120Gait imbalance (HP:0002141)2.05241162
121Abnormal hair whorl (HP:0010721)2.05187366
122Abnormality of the neuromuscular junction (HP:0003398)2.04711520
123Fatigable weakness (HP:0003473)2.04711520
124Gowers sign (HP:0003391)2.02214021
125Progressive external ophthalmoplegia (HP:0000590)1.98283351
126Ventricular fibrillation (HP:0001663)1.97894771
127Limb-girdle muscle weakness (HP:0003325)1.97135727
128Amblyopia (HP:0000646)1.97012738
129Lipoatrophy (HP:0100578)1.96901095
130Athetosis (HP:0002305)1.96408898
131Congenital primary aphakia (HP:0007707)1.95392956
132Inability to walk (HP:0002540)1.94024902
133Resting tremor (HP:0002322)1.92988221
134Fetal akinesia sequence (HP:0001989)1.92901421
135Ankle clonus (HP:0011448)1.92133608
136Testicular atrophy (HP:0000029)1.91959549
137Increased serum lactate (HP:0002151)1.91440260
138Reduced subcutaneous adipose tissue (HP:0003758)1.90844810
139Abnormality of the shoulder girdle musculature (HP:0001435)1.90743784
140Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.90026132
141Genital tract atresia (HP:0001827)1.88476156
142Poor suck (HP:0002033)1.88255911
143Proximal amyotrophy (HP:0007126)1.86949409
144Vaginal atresia (HP:0000148)1.86828168
145Right ventricular cardiomyopathy (HP:0011663)1.86698937
146CNS demyelination (HP:0007305)1.86588250
147Exercise intolerance (HP:0003546)1.86154750
148Supranuclear gaze palsy (HP:0000605)1.84763467
149Hyperthyroidism (HP:0000836)1.84110134
150Hyperuricemia (HP:0002149)1.83173506
151Increased purine levels (HP:0004368)1.83173506
152Gaze-evoked nystagmus (HP:0000640)1.82792583
153Anxiety (HP:0000739)1.81914348
154Ragged-red muscle fibers (HP:0003200)1.80904265
155Nephrogenic diabetes insipidus (HP:0009806)1.80703630
156Waddling gait (HP:0002515)1.79889744
157Hypoventilation (HP:0002791)1.79634364
158Gout (HP:0001997)1.79373844
159Annular pancreas (HP:0001734)1.78960756
160Medial flaring of the eyebrow (HP:0010747)1.78375689
161Impaired social interactions (HP:0000735)1.77657547
162Abnormal social behavior (HP:0012433)1.77657547
163Hip contracture (HP:0003273)1.76704099
164Abnormality of the labia minora (HP:0012880)1.75383418
165Hypercortisolism (HP:0001578)1.75199502
166Foot dorsiflexor weakness (HP:0009027)1.74712587
167Bradycardia (HP:0001662)1.74318441
168Abnormality of glycine metabolism (HP:0010895)1.72206767
169Abnormality of serine family amino acid metabolism (HP:0010894)1.72206767
170Optic disc pallor (HP:0000543)1.72012564
171Muscular dystrophy (HP:0003560)1.71218410
172Hammertoe (HP:0001765)1.70862757
173Poor coordination (HP:0002370)1.70033943
174Abnormality of the foot musculature (HP:0001436)1.69533050
175Bradykinesia (HP:0002067)1.69514020
176Spastic tetraplegia (HP:0002510)1.67522072
177Hypoalphalipoproteinemia (HP:0003233)1.67266743
178Distal sensory impairment (HP:0002936)1.66911364
179Diaphragmatic weakness (HP:0009113)1.66713582
180Respiratory insufficiency due to muscle weakness (HP:0002747)1.66472680
181Back pain (HP:0003418)1.63929373
182Breech presentation (HP:0001623)1.62512574
183Long clavicles (HP:0000890)1.61656320
184Abnormality of the salivary glands (HP:0010286)1.59743458
185Achilles tendon contracture (HP:0001771)1.59335909
186Abnormal atrioventricular conduction (HP:0005150)1.57544440
187Short palpebral fissure (HP:0012745)1.56942408
188Abnormality of the umbilical cord (HP:0010881)1.56833907
189Metatarsus adductus (HP:0001840)1.56278702
190Insulin-resistant diabetes mellitus (HP:0000831)1.51696193

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN8.28663960
2TTN4.91945891
3NTRK33.58898636
4MAP3K123.04467076
5PDK42.97379790
6PDK32.97379790
7PNCK2.92697256
8MINK12.91363703
9TSSK62.82823115
10MAP3K42.78221752
11LMTK22.75871592
12CASK2.62545266
13LATS22.60693403
14MST1R2.53268695
15MAP2K72.50279536
16AKT32.44855981
17MAP3K92.43891765
18PHKG22.11751018
19PHKG12.11751018
20MAP2K42.08918579
21ARAF2.00913583
22NTRK11.92222408
23GRK51.88099384
24MAP3K31.84763765
25PDK21.83193163
26MAP2K31.79140454
27NEK11.78339990
28MET1.71571893
29NME11.66405481
30PBK1.61813659
31STK241.61423530
32FER1.53507676
33MOS1.52740336
34PIK3CG1.44162878
35PLK21.41876989
36MAPKAPK31.39535345
37PAK41.38819714
38KSR21.34387764
39ERBB41.34059347
40PRKCG1.30821606
41STK161.30423074
42MARK11.29569612
43TESK11.27792206
44MYLK1.25122759
45VRK21.20737286
46RPS6KB21.17769601
47CAMK2G1.14992232
48MUSK1.14506228
49MAP2K11.09357422
50DMPK1.08737831
51LATS11.08514371
52CSNK1G31.08258533
53CSNK1G21.07920473
54LIMK11.07332664
55TTK1.07121124
56CAMK2B1.07106549
57NEK91.04298785
58RIPK10.97483808
59PTK20.97089727
60SCYL20.96175957
61DAPK10.95645580
62EEF2K0.93979005
63BUB10.93608316
64EPHA20.89074921
65CDK50.88680448
66STK38L0.87874615
67CAMK2D0.87760284
68PINK10.87720356
69MAPK120.86642874
70SGK20.85269758
71SGK2230.80941859
72SGK4940.80941859
73MAP3K70.80401645
74CSNK1G10.79839094
75TNK20.78413835
76CAMK2A0.77294914
77SMG10.76860533
78PRKCE0.76618332
79STK380.75131203
80AKT20.75097943
81BRAF0.72718883
82MAP3K20.70518769
83PDGFRA0.69636481
84WNK10.68254269
85SIK30.67431042
86KSR10.66087738
87SIK10.66054927
88EPHA40.65829648
89TAF10.65427930
90CDK90.64746823
91CAMK1G0.64172356
92PAK60.62659949
93BCR0.61132231
94RET0.60294890
95TRPM70.59410664
96WEE10.56821508
97SRPK10.55951178
98CAMK1D0.55546374
99CDK140.55427936
100PAK30.55408734
101ERBB30.55043486
102AURKA0.54377120
103NME20.54112123
104MTOR0.53499610
105MAP3K110.53383303
106BCKDK0.52655592
107PDPK10.51899012
108RIPK40.51476300
109MAP3K100.51090884
110CSNK1E0.50154331
111MAPK130.49613945
112EPHB20.49273773
113PLK30.49263311
114BMX0.48883757
115SGK30.48431681
116ICK0.45522834
117PRKCI0.45350587
118PTK2B0.43528340
119RPS6KA20.41559756
120CDK180.41361839
121TRIB30.41319183
122PRKACA0.40856086
123MATK0.39476297
124STK30.39301732
125MAP3K130.38206424
126DAPK20.37538184
127MAPK100.37135166
128PRKG20.37121327
129STK390.36876192
130CAMKK20.35793372
131PDK10.35284728
132CSNK1A10.35284205
133MST40.35265604
134ADRBK20.34882330
135ILK0.33644846
136DYRK1B0.33445155
137CDK70.32756617
138CDK150.32755270
139NTRK20.32109795
140PRKD30.31189404
141PLK10.30294824
142BRSK10.30095049
143DDR20.29870858
144CCNB10.29202079
145ROCK20.29196701
146PRKACG0.29193250
147CDC70.28946200
148MAP3K60.28277544
149ROCK10.27572252
150PTK60.27042113
151TAOK10.25651164
152PAK10.25113103
153ABL20.24904097
154AURKB0.24136376
155MAPK70.23649273
156RPS6KB10.23623376
157YES10.22111872
158PRKAA20.21948523
159MAP3K10.20976823
160TRIM280.20923033
161PRKAA10.20198397
162TIE10.19368840
163FGFR10.19096694

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.10448854
2Olfactory transduction_Homo sapiens_hsa047403.48934984
3Synaptic vesicle cycle_Homo sapiens_hsa047213.36892393
4Oxidative phosphorylation_Homo sapiens_hsa001903.05236622
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.01274023
6Collecting duct acid secretion_Homo sapiens_hsa049662.73919032
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.71836893
8Parkinsons disease_Homo sapiens_hsa050122.66547669
9Dilated cardiomyopathy_Homo sapiens_hsa054142.56815734
10Arginine biosynthesis_Homo sapiens_hsa002202.54331121
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.46678262
12Nicotine addiction_Homo sapiens_hsa050332.43983956
13Arginine and proline metabolism_Homo sapiens_hsa003302.22863520
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.21766587
15Pentose phosphate pathway_Homo sapiens_hsa000302.15642768
16Pyruvate metabolism_Homo sapiens_hsa006202.10622676
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.08750019
18Vitamin B6 metabolism_Homo sapiens_hsa007502.08529856
19Galactose metabolism_Homo sapiens_hsa000521.95732748
20Vibrio cholerae infection_Homo sapiens_hsa051101.89036309
21Alzheimers disease_Homo sapiens_hsa050101.87198046
22GABAergic synapse_Homo sapiens_hsa047271.81308507
23Huntingtons disease_Homo sapiens_hsa050161.77862886
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.77393319
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.76873060
26Circadian rhythm_Homo sapiens_hsa047101.70343654
27Taste transduction_Homo sapiens_hsa047421.64069409
28Propanoate metabolism_Homo sapiens_hsa006401.63918035
29Dopaminergic synapse_Homo sapiens_hsa047281.62960211
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.61359696
31Tight junction_Homo sapiens_hsa045301.60992548
32Thyroid cancer_Homo sapiens_hsa052161.57961246
33Proteasome_Homo sapiens_hsa030501.56727585
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.53594287
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.48756235
36Folate biosynthesis_Homo sapiens_hsa007901.45076711
37Morphine addiction_Homo sapiens_hsa050321.42686054
38Long-term potentiation_Homo sapiens_hsa047201.42619308
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.42485570
40Adherens junction_Homo sapiens_hsa045201.39681243
41Circadian entrainment_Homo sapiens_hsa047131.36673941
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.35707043
43Salivary secretion_Homo sapiens_hsa049701.34500988
44Sulfur relay system_Homo sapiens_hsa041221.34484832
45Amphetamine addiction_Homo sapiens_hsa050311.32680878
46Starch and sucrose metabolism_Homo sapiens_hsa005001.27529210
47Cardiac muscle contraction_Homo sapiens_hsa042601.25243010
48Carbon metabolism_Homo sapiens_hsa012001.25070077
49Insulin secretion_Homo sapiens_hsa049111.21525944
50Sulfur metabolism_Homo sapiens_hsa009201.18100781
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14899560
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.12282188
53Oocyte meiosis_Homo sapiens_hsa041141.12008796
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.10854347
55Glutamatergic synapse_Homo sapiens_hsa047241.05960327
56Fatty acid biosynthesis_Homo sapiens_hsa000611.04865556
57Renin secretion_Homo sapiens_hsa049241.04243858
58Calcium signaling pathway_Homo sapiens_hsa040201.02346368
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.01324883
60Gastric acid secretion_Homo sapiens_hsa049711.01029355
61Serotonergic synapse_Homo sapiens_hsa047260.96645781
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95930016
63Cholinergic synapse_Homo sapiens_hsa047250.94469605
64Regulation of autophagy_Homo sapiens_hsa041400.94444086
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94052657
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86662168
67Fatty acid degradation_Homo sapiens_hsa000710.86602512
68Glucagon signaling pathway_Homo sapiens_hsa049220.86523622
69Gap junction_Homo sapiens_hsa045400.80368048
70DNA replication_Homo sapiens_hsa030300.78990057
71Selenocompound metabolism_Homo sapiens_hsa004500.77679369
72Butanoate metabolism_Homo sapiens_hsa006500.77456962
73Insulin resistance_Homo sapiens_hsa049310.76617109
74Glutathione metabolism_Homo sapiens_hsa004800.76594535
75One carbon pool by folate_Homo sapiens_hsa006700.75687350
76Focal adhesion_Homo sapiens_hsa045100.75335636
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74826929
78Insulin signaling pathway_Homo sapiens_hsa049100.73969313
79Glycerolipid metabolism_Homo sapiens_hsa005610.73015876
80Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72691414
81ECM-receptor interaction_Homo sapiens_hsa045120.71825142
82Tyrosine metabolism_Homo sapiens_hsa003500.71459537
83Estrogen signaling pathway_Homo sapiens_hsa049150.71377623
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.70872884
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69868156
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69445416
87GnRH signaling pathway_Homo sapiens_hsa049120.66653092
88cAMP signaling pathway_Homo sapiens_hsa040240.65095118
89Mismatch repair_Homo sapiens_hsa034300.64565123
90Fructose and mannose metabolism_Homo sapiens_hsa000510.63982436
91Melanoma_Homo sapiens_hsa052180.63626603
92PPAR signaling pathway_Homo sapiens_hsa033200.63363918
93Melanogenesis_Homo sapiens_hsa049160.63362697
94Long-term depression_Homo sapiens_hsa047300.62599097
95Cocaine addiction_Homo sapiens_hsa050300.62158809
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61525095
97Oxytocin signaling pathway_Homo sapiens_hsa049210.61386447
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61347457
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.61180566
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60374973
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59487309
102Fatty acid metabolism_Homo sapiens_hsa012120.58954247
103mRNA surveillance pathway_Homo sapiens_hsa030150.58530204
104Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56865289
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56377947
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.55385544
107RNA transport_Homo sapiens_hsa030130.55102533
108Bladder cancer_Homo sapiens_hsa052190.54166849
109Hippo signaling pathway_Homo sapiens_hsa043900.54118142
110beta-Alanine metabolism_Homo sapiens_hsa004100.53997430
111Thyroid hormone synthesis_Homo sapiens_hsa049180.52545560
112AMPK signaling pathway_Homo sapiens_hsa041520.51571461
113Phototransduction_Homo sapiens_hsa047440.50227838
114Proteoglycans in cancer_Homo sapiens_hsa052050.49539517
115Histidine metabolism_Homo sapiens_hsa003400.48534616
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47487917
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47201637
118Base excision repair_Homo sapiens_hsa034100.46024123
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45957641
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42744333
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41108553
122Fatty acid elongation_Homo sapiens_hsa000620.40966508
123Phenylalanine metabolism_Homo sapiens_hsa003600.40931077
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.40720356
125ErbB signaling pathway_Homo sapiens_hsa040120.39916821
126Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39575364
127Rheumatoid arthritis_Homo sapiens_hsa053230.39492069
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39069229
129Phagosome_Homo sapiens_hsa041450.37313605
130Nucleotide excision repair_Homo sapiens_hsa034200.36700379
131Purine metabolism_Homo sapiens_hsa002300.36047971
132Biosynthesis of amino acids_Homo sapiens_hsa012300.33801154
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33590322
134Metabolic pathways_Homo sapiens_hsa011000.33193230
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32538071
136Glioma_Homo sapiens_hsa052140.32442072
137Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31496094
138Cell cycle_Homo sapiens_hsa041100.30090999
139Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29977075
140Dorso-ventral axis formation_Homo sapiens_hsa043200.28816275
141Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28621098
142Adipocytokine signaling pathway_Homo sapiens_hsa049200.26836494
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26118126
144Wnt signaling pathway_Homo sapiens_hsa043100.25703993
145Peroxisome_Homo sapiens_hsa041460.24743917
146Endocytosis_Homo sapiens_hsa041440.23838577
147Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23743971
148Spliceosome_Homo sapiens_hsa030400.23590424
149Cyanoamino acid metabolism_Homo sapiens_hsa004600.23568316
150Rap1 signaling pathway_Homo sapiens_hsa040150.22598414
151Amoebiasis_Homo sapiens_hsa051460.22460543
152Prostate cancer_Homo sapiens_hsa052150.20946587
153Endometrial cancer_Homo sapiens_hsa052130.20105701
154Lysine degradation_Homo sapiens_hsa003100.19224971

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