KCNV1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This protein is essentially present in the brain, and its role might be to inhibit the function of a particular class of outward rectifier potassium channel types. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)6.03613511
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.89707841
3glutamate secretion (GO:0014047)5.85526355
4synaptic vesicle exocytosis (GO:0016079)5.77837877
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.73117294
6regulation of short-term neuronal synaptic plasticity (GO:0048172)5.68131188
7vocalization behavior (GO:0071625)5.64837257
8protein localization to synapse (GO:0035418)5.43893424
9regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.39000678
10regulation of glutamate receptor signaling pathway (GO:1900449)5.31960932
11regulation of synaptic vesicle exocytosis (GO:2000300)5.14973133
12neuron cell-cell adhesion (GO:0007158)5.14015611
13locomotory exploration behavior (GO:0035641)5.01423510
14neurotransmitter-gated ion channel clustering (GO:0072578)4.96019767
15neuronal action potential propagation (GO:0019227)4.92854521
16presynaptic membrane assembly (GO:0097105)4.89228869
17synaptic vesicle maturation (GO:0016188)4.85845735
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.74687696
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.65518471
20regulation of synaptic vesicle transport (GO:1902803)4.56207515
21glutamate receptor signaling pathway (GO:0007215)4.55360645
22presynaptic membrane organization (GO:0097090)4.48012829
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.36266796
24detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.35140488
25neuron-neuron synaptic transmission (GO:0007270)4.34498884
26synaptic transmission, glutamatergic (GO:0035249)4.30319531
27gamma-aminobutyric acid signaling pathway (GO:0007214)4.28987642
28positive regulation of neurotransmitter secretion (GO:0001956)4.25620358
29regulation of excitatory postsynaptic membrane potential (GO:0060079)4.25315739
30postsynaptic membrane organization (GO:0001941)4.20936902
31regulation of neuronal synaptic plasticity (GO:0048168)4.16052478
32long-term synaptic potentiation (GO:0060291)4.14117007
33exploration behavior (GO:0035640)4.10622208
34regulation of postsynaptic membrane potential (GO:0060078)4.08828249
35negative regulation of synaptic transmission, GABAergic (GO:0032229)4.06004519
36neurotransmitter secretion (GO:0007269)4.03846139
37response to histamine (GO:0034776)3.98630504
38tryptophan catabolic process (GO:0006569)3.90823996
39indole-containing compound catabolic process (GO:0042436)3.90823996
40indolalkylamine catabolic process (GO:0046218)3.90823996
41regulation of synaptic plasticity (GO:0048167)3.90361443
42positive regulation of membrane potential (GO:0045838)3.87291691
43positive regulation of synapse maturation (GO:0090129)3.83685758
44indolalkylamine metabolic process (GO:0006586)3.76713910
45behavioral response to cocaine (GO:0048148)3.75975007
46regulation of dendritic spine morphogenesis (GO:0061001)3.74147925
47cerebellar granule cell differentiation (GO:0021707)3.70623290
48regulation of synaptic transmission, glutamatergic (GO:0051966)3.69938990
49neuron recognition (GO:0008038)3.68554760
50synaptic vesicle endocytosis (GO:0048488)3.68072255
51G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.67701006
52long-term memory (GO:0007616)3.67645741
53kynurenine metabolic process (GO:0070189)3.67311665
54regulation of neurotransmitter secretion (GO:0046928)3.65807984
55positive regulation of neurotransmitter transport (GO:0051590)3.65750918
56G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.64567548
57behavioral response to nicotine (GO:0035095)3.62834932
58neural tube formation (GO:0001841)3.61442549
59positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.59300113
60regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.58072271
61membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.57705305
62regulation of glutamate secretion (GO:0014048)3.55905206
63dendritic spine morphogenesis (GO:0060997)3.51626036
64auditory receptor cell stereocilium organization (GO:0060088)3.51605604
65regulation of dendritic spine development (GO:0060998)3.49462259
66fear response (GO:0042596)3.48251349
67regulation of voltage-gated calcium channel activity (GO:1901385)3.47706741
68regulation of synapse structural plasticity (GO:0051823)3.44926921
69indole-containing compound metabolic process (GO:0042430)3.44555537
70activation of protein kinase A activity (GO:0034199)3.44048191
71primary amino compound metabolic process (GO:1901160)3.43522513
72behavioral defense response (GO:0002209)3.43448169
73behavioral fear response (GO:0001662)3.43448169
74detection of light stimulus involved in sensory perception (GO:0050962)3.38157985
75detection of light stimulus involved in visual perception (GO:0050908)3.38157985
76retinal cone cell development (GO:0046549)3.35958685
77negative regulation of cytosolic calcium ion concentration (GO:0051481)3.35834409
78protein K11-linked deubiquitination (GO:0035871)3.34845170
79negative regulation of dendrite morphogenesis (GO:0050774)3.34506104
80L-fucose catabolic process (GO:0042355)3.34116736
81fucose catabolic process (GO:0019317)3.34116736
82L-fucose metabolic process (GO:0042354)3.34116736
83axonal fasciculation (GO:0007413)3.33463073
84layer formation in cerebral cortex (GO:0021819)3.32893239
85regulation of vesicle fusion (GO:0031338)3.31826288
86regulation of neurotransmitter transport (GO:0051588)3.30471386
87membrane depolarization (GO:0051899)3.26795042
88neurotransmitter transport (GO:0006836)3.26092737
89tryptophan metabolic process (GO:0006568)3.25679267
90behavioral response to ethanol (GO:0048149)3.24703259
91reflex (GO:0060004)3.23031106
92auditory behavior (GO:0031223)3.22507601
93mechanosensory behavior (GO:0007638)3.22005091
94positive regulation of synaptic transmission (GO:0050806)3.20711433
95regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.19505435
96cellular potassium ion homeostasis (GO:0030007)3.18734351
97signal peptide processing (GO:0006465)3.16200606
98negative regulation of amino acid transport (GO:0051956)3.15079596
99photoreceptor cell maintenance (GO:0045494)3.14413715
100inner ear receptor stereocilium organization (GO:0060122)3.14313634
101detection of mechanical stimulus involved in sensory perception (GO:0050974)3.13831661
102learning (GO:0007612)3.13360464
103neuronal action potential (GO:0019228)3.13233150
104long term synaptic depression (GO:0060292)3.11417158
105negative regulation of dendrite development (GO:2000171)3.09800988
106regulation of synaptic transmission (GO:0050804)3.09443891
107regulation of sarcomere organization (GO:0060297)3.08900675
108righting reflex (GO:0060013)3.06026739
109proline transport (GO:0015824)3.05943057
110cilium or flagellum-dependent cell motility (GO:0001539)3.03622854
111* synaptic transmission (GO:0007268)3.02228240
112gamma-aminobutyric acid transport (GO:0015812)3.01223105
113regulation of synapse maturation (GO:0090128)3.01091975
114detection of calcium ion (GO:0005513)3.00459881
115regulation of neurotransmitter levels (GO:0001505)3.00365087
116C4-dicarboxylate transport (GO:0015740)2.98623466
117serotonin metabolic process (GO:0042428)2.97613291
118cerebellar Purkinje cell differentiation (GO:0021702)2.97403138
119positive regulation of cardiac muscle cell differentiation (GO:2000727)2.96546324
120positive regulation of synapse assembly (GO:0051965)2.95958747
121cochlea development (GO:0090102)2.93697267
122synapse assembly (GO:0007416)2.92293557
123dendritic spine organization (GO:0097061)2.91679218
124response to auditory stimulus (GO:0010996)2.89819640
125membrane hyperpolarization (GO:0060081)2.89284296
126cornea development in camera-type eye (GO:0061303)2.88944179
127neuromuscular process controlling balance (GO:0050885)2.88872648
128membrane depolarization during action potential (GO:0086010)2.87252112
129regulation of hippo signaling (GO:0035330)2.86915457
130innervation (GO:0060384)2.86825496
131establishment of synaptic vesicle localization (GO:0097480)2.85975098
132synaptic vesicle transport (GO:0048489)2.85975098
133glycosphingolipid biosynthetic process (GO:0006688)2.85574498
134transmission of nerve impulse (GO:0019226)2.85345284
135startle response (GO:0001964)2.85009416
136central nervous system neuron axonogenesis (GO:0021955)2.84880711
137establishment of protein localization to Golgi (GO:0072600)2.84130309
138protein localization to cilium (GO:0061512)2.79043497
139cellular ketone body metabolic process (GO:0046950)2.76458291
140central nervous system projection neuron axonogenesis (GO:0021952)2.72143940
141tachykinin receptor signaling pathway (GO:0007217)2.70509982
142response to pheromone (GO:0019236)2.62062892
143DNA double-strand break processing (GO:0000729)2.60104551
144regulation of neurotransmitter uptake (GO:0051580)2.55592992
145central nervous system myelination (GO:0022010)2.55353201
146axon ensheathment in central nervous system (GO:0032291)2.55353201
147adult walking behavior (GO:0007628)2.54087696
148* potassium ion transmembrane transport (GO:0071805)2.51661746
149* cellular potassium ion transport (GO:0071804)2.51661746
150cAMP catabolic process (GO:0006198)2.50861642
151ketone body metabolic process (GO:1902224)2.50843857
152cilium morphogenesis (GO:0060271)2.46104491
153axoneme assembly (GO:0035082)2.46013883
154positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.45861295
155cyclic nucleotide catabolic process (GO:0009214)2.45485194
156dopamine transport (GO:0015872)2.45397202
157regulation of calcium ion-dependent exocytosis (GO:0017158)2.45147384
158action potential (GO:0001508)2.42627129
159adaptation of signaling pathway (GO:0023058)2.42250529
160cellular biogenic amine catabolic process (GO:0042402)2.41498804
161amine catabolic process (GO:0009310)2.41498804
162photoreceptor cell development (GO:0042461)2.39890729
163benzene-containing compound metabolic process (GO:0042537)2.39483319
164regulation of pigment cell differentiation (GO:0050932)2.39168912

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.11524741
2GBX2_23144817_ChIP-Seq_PC3_Human4.43742300
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.27260297
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.13509114
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.09508150
6* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.75659379
7REST_21632747_ChIP-Seq_MESCs_Mouse2.68028451
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65490131
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65490131
10* RARB_27405468_Chip-Seq_BRAIN_Mouse2.61400965
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60354405
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55544828
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52091645
14TAF15_26573619_Chip-Seq_HEK293_Human2.51382165
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.51356572
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44100515
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41306845
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.36416321
19* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18896610
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.16665198
21DROSHA_22980978_ChIP-Seq_HELA_Human2.15135096
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.13838854
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.12003840
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.10743497
25* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06349333
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.04923456
27SALL1_21062744_ChIP-ChIP_HESCs_Human2.00533325
28* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99427623
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.96662694
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94456381
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85090016
32SMAD4_21799915_ChIP-Seq_A2780_Human1.84893304
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79165321
34* EWS_26573619_Chip-Seq_HEK293_Human1.78432198
35P300_19829295_ChIP-Seq_ESCs_Human1.76286855
36AR_21572438_ChIP-Seq_LNCaP_Human1.75902624
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.75642901
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74462517
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.69361820
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.68541059
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61278551
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61171249
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59126645
44CBP_20019798_ChIP-Seq_JUKART_Human1.55571573
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55571573
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.54247709
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51498794
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50741897
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.50174953
50* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46223288
51* FUS_26573619_Chip-Seq_HEK293_Human1.43397939
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42818828
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40240875
54TCF4_22108803_ChIP-Seq_LS180_Human1.39260861
55AR_25329375_ChIP-Seq_VCAP_Human1.39043171
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.38510531
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.38376090
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37922052
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37429677
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37062694
61* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35342125
62* PIAS1_25552417_ChIP-Seq_VCAP_Human1.34647289
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.32766135
64FLI1_21867929_ChIP-Seq_TH2_Mouse1.32170298
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31098364
66* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30752325
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30472576
68STAT3_23295773_ChIP-Seq_U87_Human1.29930751
69KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29479511
70TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.29346457
71* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28067339
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26243374
73EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24822445
74* CBX2_27304074_Chip-Seq_ESCs_Mouse1.24794129
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.24353735
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.23536235
77* NANOG_19829295_ChIP-Seq_ESCs_Human1.23482997
78* SOX2_19829295_ChIP-Seq_ESCs_Human1.23482997
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23444966
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23306551
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22574052
82P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22447939
83* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21802739
84TCF4_23295773_ChIP-Seq_U87_Human1.20503029
85RNF2_27304074_Chip-Seq_NSC_Mouse1.19774607
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19245704
87* ARNT_22903824_ChIP-Seq_MCF-7_Human1.18934884
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18475329
89TP53_16413492_ChIP-PET_HCT116_Human1.18354080
90P53_22387025_ChIP-Seq_ESCs_Mouse1.18228095
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17535955
92CRX_20693478_ChIP-Seq_RETINA_Mouse1.17393119
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.17367716
94ZNF274_21170338_ChIP-Seq_K562_Hela1.16044241
95TP53_22573176_ChIP-Seq_HFKS_Human1.15436507
96AR_19668381_ChIP-Seq_PC3_Human1.15267029
97* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14457760
98TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.14205206
99BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13701910
100RING1B_27294783_Chip-Seq_ESCs_Mouse1.13666092
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13064994
102* VDR_22108803_ChIP-Seq_LS180_Human1.11317764
103* KDM2B_26808549_Chip-Seq_REH_Human1.10498785
104* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09151811
105TP53_18474530_ChIP-ChIP_U2OS_Human1.08948792
106CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08286979
107MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07683091
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07606962
109CDX2_22108803_ChIP-Seq_LS180_Human1.07591426
110CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07339598
111NANOG_18555785_Chip-Seq_ESCs_Mouse1.07022562
112CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06539702
113RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06536432
114* AHR_22903824_ChIP-Seq_MCF-7_Human1.06518276
115CMYC_18555785_Chip-Seq_ESCs_Mouse1.06457532
116FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06154490
117STAT3_18555785_Chip-Seq_ESCs_Mouse1.05736511
118TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05517061
119ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05383411
120SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04943733
121JUN_21703547_ChIP-Seq_K562_Human1.04098333
122OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03825654
123MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03815905
124* RUNX2_22187159_ChIP-Seq_PCA_Human1.03754934
125YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02622970
126SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02196562
127WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00667277
128DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99862734
129* ER_23166858_ChIP-Seq_MCF-7_Human0.98076716
130TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95252192
131POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95252192
132E2F1_18555785_Chip-Seq_ESCs_Mouse0.94882357
133RING1B_27294783_Chip-Seq_NPCs_Mouse0.94800777
134VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93483765
135IGF1R_20145208_ChIP-Seq_DFB_Human0.93391145
136NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93134352
137BCAT_22108803_ChIP-Seq_LS180_Human0.92253064
138* RXR_22108803_ChIP-Seq_LS180_Human0.92064936
139SMAD3_21741376_ChIP-Seq_ESCs_Human0.91732564
140SMAD3_21741376_ChIP-Seq_HESCs_Human0.91185945
141* SOX9_26525672_Chip-Seq_HEART_Mouse0.90703750

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.45876578
2MP0003880_abnormal_central_pattern6.12160170
3MP0003635_abnormal_synaptic_transmissio4.27868300
4MP0004270_analgesia3.98856323
5MP0009745_abnormal_behavioral_response3.75658069
6MP0000569_abnormal_digit_pigmentation3.74641376
7MP0001968_abnormal_touch/_nociception3.62616389
8MP0002063_abnormal_learning/memory/cond3.54677267
9MP0002064_seizures3.30046835
10MP0002572_abnormal_emotion/affect_behav3.01276053
11MP0002736_abnormal_nociception_after2.98399189
12* MP0009046_muscle_twitch2.75131821
13MP0002272_abnormal_nervous_system2.66691168
14MP0008877_abnormal_DNA_methylation2.65446053
15MP0002735_abnormal_chemical_nociception2.64510007
16MP0002734_abnormal_mechanical_nocicepti2.58145680
17MP0001486_abnormal_startle_reflex2.53883888
18MP0002822_catalepsy2.45784759
19MP0001501_abnormal_sleep_pattern2.41888336
20MP0001440_abnormal_grooming_behavior2.36413998
21MP0009780_abnormal_chondrocyte_physiolo2.17218655
22MP0003195_calcinosis2.15580394
23MP0003879_abnormal_hair_cell2.13515467
24MP0002067_abnormal_sensory_capabilities2.09121654
25MP0005423_abnormal_somatic_nervous2.01281962
26MP0004147_increased_porphyrin_level1.98472956
27MP0002733_abnormal_thermal_nociception1.96152022
28MP0001970_abnormal_pain_threshold1.93693596
29MP0003329_amyloid_beta_deposits1.92890267
30MP0002638_abnormal_pupillary_reflex1.89944942
31MP0002102_abnormal_ear_morphology1.84903473
32MP0005386_behavior/neurological_phenoty1.74768004
33MP0004924_abnormal_behavior1.74768004
34MP0008057_abnormal_DNA_replication1.73478765
35MP0000778_abnormal_nervous_system1.72236338
36MP0004043_abnormal_pH_regulation1.66951209
37MP0006292_abnormal_olfactory_placode1.66706238
38MP0002557_abnormal_social/conspecific_i1.65757995
39MP0002184_abnormal_innervation1.65160425
40MP0004811_abnormal_neuron_physiology1.59134418
41MP0008569_lethality_at_weaning1.57777699
42MP0005646_abnormal_pituitary_gland1.54458849
43MP0002837_dystrophic_cardiac_calcinosis1.54261206
44MP0001984_abnormal_olfaction1.53317208
45MP0000427_abnormal_hair_cycle1.52813961
46MP0006276_abnormal_autonomic_nervous1.47424334
47MP0005253_abnormal_eye_physiology1.43247398
48MP0001529_abnormal_vocalization1.42310226
49MP0003633_abnormal_nervous_system1.41930498
50MP0003787_abnormal_imprinting1.41481703
51MP0004858_abnormal_nervous_system1.39526790
52MP0001188_hyperpigmentation1.36943714
53* MP0002066_abnormal_motor_capabilities/c1.35325748
54MP0000955_abnormal_spinal_cord1.34278377
55MP0001905_abnormal_dopamine_level1.33754016
56MP0003646_muscle_fatigue1.31254061
57MP0001986_abnormal_taste_sensitivity1.31203603
58MP0000372_irregular_coat_pigmentation1.28453924
59MP0002882_abnormal_neuron_morphology1.27062159
60MP0002909_abnormal_adrenal_gland1.26100172
61MP0002938_white_spotting1.25233377
62MP0005174_abnormal_tail_pigmentation1.22266608
63MP0001502_abnormal_circadian_rhythm1.21404594
64MP0006072_abnormal_retinal_apoptosis1.19867703
65MP0003136_yellow_coat_color1.17963273
66MP0003631_nervous_system_phenotype1.14712109
67MP0000383_abnormal_hair_follicle1.13946998
68MP0008872_abnormal_physiological_respon1.13010608
69MP0004145_abnormal_muscle_electrophysio1.12405371
70MP0002876_abnormal_thyroid_physiology1.10384306
71MP0008874_decreased_physiological_sensi1.02925300
72MP0000751_myopathy1.00621088
73MP0005167_abnormal_blood-brain_barrier1.00360063
74MP0003121_genomic_imprinting0.97752295
75MP0004142_abnormal_muscle_tone0.96843962
76MP0002152_abnormal_brain_morphology0.96833636
77MP0002234_abnormal_pharynx_morphology0.94952532
78MP0004484_altered_response_of0.94903460
79MP0001963_abnormal_hearing_physiology0.93742615
80MP0002928_abnormal_bile_duct0.93373710
81MP0004742_abnormal_vestibular_system0.93333680
82MP0004085_abnormal_heartbeat0.92309310
83MP0005535_abnormal_body_temperature0.91867935
84MP0000604_amyloidosis0.91592640
85MP0002069_abnormal_eating/drinking_beha0.91174656
86MP0004885_abnormal_endolymph0.90010491
87MP0003137_abnormal_impulse_conducting0.89919850
88MP0010386_abnormal_urinary_bladder0.87707333
89MP0005645_abnormal_hypothalamus_physiol0.86025367
90MP0004133_heterotaxia0.85334202
91MP0000013_abnormal_adipose_tissue0.83913820
92MP0001664_abnormal_digestion0.82705005
93MP0004215_abnormal_myocardial_fiber0.82435435
94MP0002229_neurodegeneration0.81221860
95MP0003122_maternal_imprinting0.80202863
96MP0005551_abnormal_eye_electrophysiolog0.80173937
97MP0002751_abnormal_autonomic_nervous0.78852320
98MP0005171_absent_coat_pigmentation0.78527543
99MP0003045_fibrosis0.78306867
100MP0003075_altered_response_to0.77320347
101MP0005195_abnormal_posterior_eye0.75394016
102MP0001485_abnormal_pinna_reflex0.75033445
103MP0004510_myositis0.74750382
104MP0003252_abnormal_bile_duct0.74446096
105MP0000230_abnormal_systemic_arterial0.73780930
106MP0001177_atelectasis0.73588994
107MP0005310_abnormal_salivary_gland0.73151139
108MP0003698_abnormal_male_reproductive0.70196265
109MP0005410_abnormal_fertilization0.69310555
110MP0008875_abnormal_xenobiotic_pharmacok0.68164037
111MP0005409_darkened_coat_color0.67925605
112MP0010678_abnormal_skin_adnexa0.67321449
113MP0010234_abnormal_vibrissa_follicle0.67018341
114MP0008004_abnormal_stomach_pH0.65410412
115MP0000631_abnormal_neuroendocrine_gland0.64922232
116MP0002752_abnormal_somatic_nervous0.61625796
117MP0003632_abnormal_nervous_system0.61246716
118MP0000920_abnormal_myelination0.58541417
119MP0005623_abnormal_meninges_morphology0.58263592
120MP0001943_abnormal_respiration0.55322585
121MP0005499_abnormal_olfactory_system0.55154769
122MP0005394_taste/olfaction_phenotype0.55154769
123MP0002090_abnormal_vision0.54143809
124MP0000026_abnormal_inner_ear0.53669344
125MP0005187_abnormal_penis_morphology0.53102770
126MP0003634_abnormal_glial_cell0.52585028
127MP0001765_abnormal_ion_homeostasis0.52333950
128MP0004233_abnormal_muscle_weight0.51303096
129MP0003183_abnormal_peptide_metabolism0.49077511
130MP0005620_abnormal_muscle_contractility0.48866881
131MP0003956_abnormal_body_size0.48166448
132MP0010770_preweaning_lethality0.47232187
133MP0002082_postnatal_lethality0.47232187
134MP0010769_abnormal_survival0.46997365
135MP0004036_abnormal_muscle_relaxation0.46538816

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.38714797
2Epileptic encephalopathy (HP:0200134)6.65409522
3Myokymia (HP:0002411)6.36130996
4Focal seizures (HP:0007359)6.25431490
5Atonic seizures (HP:0010819)5.77936980
6Hyperventilation (HP:0002883)5.57802471
7Visual hallucinations (HP:0002367)5.22134138
8Absence seizures (HP:0002121)5.00205283
9Febrile seizures (HP:0002373)4.90931131
10Dialeptic seizures (HP:0011146)4.67947139
11Broad-based gait (HP:0002136)4.41501731
12Generalized tonic-clonic seizures (HP:0002069)4.18239971
13Pancreatic cysts (HP:0001737)4.09916583
14Poor eye contact (HP:0000817)4.01634209
15Amblyopia (HP:0000646)3.93480981
16Progressive cerebellar ataxia (HP:0002073)3.87605411
17True hermaphroditism (HP:0010459)3.79341093
18Gaze-evoked nystagmus (HP:0000640)3.72545570
19Pancreatic fibrosis (HP:0100732)3.71386459
20Impaired vibration sensation in the lower limbs (HP:0002166)3.51646997
21Abnormal social behavior (HP:0012433)3.37497623
22Impaired social interactions (HP:0000735)3.37497623
23Molar tooth sign on MRI (HP:0002419)3.27364206
24Abnormality of midbrain morphology (HP:0002418)3.27364206
25Congenital stationary night blindness (HP:0007642)3.27334683
26Dysdiadochokinesis (HP:0002075)3.22504852
27Inability to walk (HP:0002540)3.11728387
28Action tremor (HP:0002345)3.08692091
29Nephronophthisis (HP:0000090)3.08081366
30Attenuation of retinal blood vessels (HP:0007843)3.05096797
31Insidious onset (HP:0003587)3.04495754
32Termporal pattern (HP:0011008)3.04495754
33Excessive salivation (HP:0003781)3.03958128
34Drooling (HP:0002307)3.03958128
35Epileptiform EEG discharges (HP:0011182)3.03747097
36Truncal ataxia (HP:0002078)3.02198024
37Dysmetria (HP:0001310)3.01944205
38Urinary bladder sphincter dysfunction (HP:0002839)3.00535230
39Abnormality of the renal cortex (HP:0011035)2.95811660
40Depression (HP:0000716)2.90268591
41Protruding tongue (HP:0010808)2.88623128
42Medial flaring of the eyebrow (HP:0010747)2.79382399
43Abnormal eating behavior (HP:0100738)2.78969077
44Cerebral inclusion bodies (HP:0100314)2.77943101
45Stereotypic behavior (HP:0000733)2.77612926
46Impaired smooth pursuit (HP:0007772)2.77294693
47Abnormality of the renal medulla (HP:0100957)2.77117288
48Cystic liver disease (HP:0006706)2.76109151
49Absent speech (HP:0001344)2.73307466
50Anxiety (HP:0000739)2.72365901
51Dysmetric saccades (HP:0000641)2.71195505
52Chronic hepatic failure (HP:0100626)2.67023205
53EEG with generalized epileptiform discharges (HP:0011198)2.66605717
54Supranuclear gaze palsy (HP:0000605)2.62100078
55Urinary urgency (HP:0000012)2.61185020
56Abolished electroretinogram (ERG) (HP:0000550)2.59155114
57Scanning speech (HP:0002168)2.57740168
58Aplasia/Hypoplasia of the tibia (HP:0005772)2.53546404
59Impaired vibratory sensation (HP:0002495)2.53214379
60Ankle clonus (HP:0011448)2.51682774
61Abnormality of the lower motor neuron (HP:0002366)2.50313243
62Status epilepticus (HP:0002133)2.44756973
63Clumsiness (HP:0002312)2.43835848
64Decreased central vision (HP:0007663)2.41764524
65Fetal akinesia sequence (HP:0001989)2.41091669
66Hypsarrhythmia (HP:0002521)2.39663223
67Delusions (HP:0000746)2.37086994
68Type II lissencephaly (HP:0007260)2.34277720
69Postural instability (HP:0002172)2.34082455
70Hemiparesis (HP:0001269)2.33446164
71Congenital sensorineural hearing impairment (HP:0008527)2.32302075
72Abnormality of the corticospinal tract (HP:0002492)2.31521716
73Blue irides (HP:0000635)2.30662611
74Bradykinesia (HP:0002067)2.29946126
75Renal cortical cysts (HP:0000803)2.28158153
76Spastic gait (HP:0002064)2.28143555
77Papilledema (HP:0001085)2.26947358
78Generalized myoclonic seizures (HP:0002123)2.26633584
79Abnormality of ocular smooth pursuit (HP:0000617)2.26078254
80Abnormality of binocular vision (HP:0011514)2.26058893
81Diplopia (HP:0000651)2.26058893
82Aplasia/Hypoplasia of the tongue (HP:0010295)2.24086096
83Progressive inability to walk (HP:0002505)2.23871987
84Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.22659044
85Degeneration of the lateral corticospinal tracts (HP:0002314)2.22659044
86Genetic anticipation (HP:0003743)2.21302503
87Aplasia/Hypoplasia of the fovea (HP:0008060)2.20877775
88Hypoplasia of the fovea (HP:0007750)2.20877775
89Neurofibrillary tangles (HP:0002185)2.20813633
90Congenital primary aphakia (HP:0007707)2.20781286
91Bony spicule pigmentary retinopathy (HP:0007737)2.19604669
92Abnormal drinking behavior (HP:0030082)2.19311937
93Polydipsia (HP:0001959)2.19311937
94Intestinal atresia (HP:0011100)2.13775482
95Keratoconus (HP:0000563)2.13383272
96Increased corneal curvature (HP:0100692)2.13383272
97Genital tract atresia (HP:0001827)2.12376873
98Torticollis (HP:0000473)2.12004434
99Central scotoma (HP:0000603)2.11992316
100Abnormality of salivation (HP:0100755)2.10097055
101Incomplete penetrance (HP:0003829)2.08088548
102Focal dystonia (HP:0004373)2.07948440
103Abnormality of macular pigmentation (HP:0008002)2.06691814
104Gait ataxia (HP:0002066)2.06290217
105Furrowed tongue (HP:0000221)2.04706280
106Fair hair (HP:0002286)2.04369856
107Hyperthyroidism (HP:0000836)2.04129863
108Nephrogenic diabetes insipidus (HP:0009806)2.03785242
109Tubular atrophy (HP:0000092)2.02713065
110Resting tremor (HP:0002322)2.02217829
111Thickened helices (HP:0000391)2.00629128
112Vaginal atresia (HP:0000148)1.99716325
113Generalized hypopigmentation of hair (HP:0011358)1.99525487
114Annular pancreas (HP:0001734)1.98053082
115Lower limb amyotrophy (HP:0007210)1.96870858
116Sclerocornea (HP:0000647)1.96625052
117Hypothermia (HP:0002045)1.95833415
118Lower limb muscle weakness (HP:0007340)1.95403544
119Congenital hepatic fibrosis (HP:0002612)1.94024312
120Large for gestational age (HP:0001520)1.93870307
121Pheochromocytoma (HP:0002666)1.93340105
122Gait imbalance (HP:0002141)1.92471275
123Polyphagia (HP:0002591)1.92423802
124Lissencephaly (HP:0001339)1.91600952
125Abnormality of the labia minora (HP:0012880)1.91089543
126Optic nerve hypoplasia (HP:0000609)1.89715643
127Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.88079183
128Mutism (HP:0002300)1.87082827
129Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86890995
130Abnormality of alanine metabolism (HP:0010916)1.86890995
131Hyperalaninemia (HP:0003348)1.86890995
132Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.85917138
133Postaxial foot polydactyly (HP:0001830)1.85535571
134Abnormal rod and cone electroretinograms (HP:0008323)1.85401825
135Short chin (HP:0000331)1.82617173
136Sensory axonal neuropathy (HP:0003390)1.81612988
137Small hand (HP:0200055)1.81200364
138Abnormality of the fovea (HP:0000493)1.81199660
139Decreased circulating renin level (HP:0003351)1.81136150
140Cerebellar dysplasia (HP:0007033)1.78942534
141Absent/shortened dynein arms (HP:0200106)1.78859158
142Dynein arm defect of respiratory motile cilia (HP:0012255)1.78859158
143Volvulus (HP:0002580)1.78674130
144Intellectual disability, severe (HP:0010864)1.78518037
145Deeply set eye (HP:0000490)1.78209191
146Decreased electroretinogram (ERG) amplitude (HP:0000654)1.77641404
147Stomach cancer (HP:0012126)1.77303487
148Intention tremor (HP:0002080)1.76641895
149Craniofacial dystonia (HP:0012179)1.76640980
150Pendular nystagmus (HP:0012043)1.76008899
151Abnormality of the periventricular white matter (HP:0002518)1.75819753
152Retinal dysplasia (HP:0007973)1.75263897
153Neuroendocrine neoplasm (HP:0100634)1.74845749
154Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74670100
155Anencephaly (HP:0002323)1.72841103
156Dyskinesia (HP:0100660)1.72661909
157Ketoacidosis (HP:0001993)1.71318237
158Increased neuronal autofluorescent lipopigment (HP:0002074)1.70785386
159Gastroesophageal reflux (HP:0002020)1.70460814
160Megalencephaly (HP:0001355)1.70383275
161Male pseudohermaphroditism (HP:0000037)1.70083625
162Psychosis (HP:0000709)1.70034524
163Inappropriate behavior (HP:0000719)1.69373765
164Specific learning disability (HP:0001328)1.69308281
165Polyuria (HP:0000103)1.68996802
166Hemiplegia (HP:0002301)1.68859003
167Widely spaced teeth (HP:0000687)1.68191695

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.21788001
2EPHA45.05657551
3CASK4.65070654
4NTRK34.14332709
5DAPK23.56932521
6MAP3K93.25500204
7RIPK43.02022343
8MAP3K42.82429034
9MAP2K72.63998204
10MAP3K122.53002175
11MAP4K22.50069499
12DAPK12.43522426
13CCNB12.40748348
14BMPR1B2.37467331
15PLK22.34804779
16ADRBK22.28034169
17CDK192.27699418
18ACVR1B2.26696931
19WNK32.21087190
20MINK12.13396176
21KSR21.96816411
22MAP2K41.84796264
23KSR11.83835844
24MARK11.77995651
25INSRR1.75847580
26PAK61.73237802
27NUAK11.70599271
28ARAF1.63001479
29NTRK11.58417636
30GRK11.55570161
31PRPF4B1.53622447
32SIK21.52989713
33MKNK21.51294795
34GRK51.47743525
35BMPR21.42528054
36MAP3K131.41923254
37STK391.40663881
38CDK51.36787504
39CAMKK11.34704427
40STK38L1.30690608
41ZAK1.30542553
42PTK2B1.29458208
43OXSR11.27158074
44NTRK21.25528609
45TRIM281.24395119
46PNCK1.23011510
47AKT31.18704881
48TNIK1.12560967
49SIK31.12436313
50CAMKK21.11906366
51PRKCG1.10737788
52TAOK31.09888524
53RAF11.05069623
54CAMK2A1.04331202
55MAPK131.01163774
56PRKD31.00958409
57FES0.99965173
58MAP3K20.96467816
59NME10.89716781
60LATS10.88409637
61SGK4940.87182479
62SGK2230.87182479
63WNK40.87022414
64CAMK2B0.86744828
65CDK180.86456550
66FGR0.84164477
67DAPK30.79665745
68CDK150.79408760
69CDK140.77063070
70SGK20.76244106
71BRAF0.72536392
72CAMK10.72462364
73PKN10.70064851
74TXK0.69515148
75CDK11A0.69067098
76TYRO30.69028561
77STK30.68152275
78BRSK20.67382282
79MKNK10.67102473
80UHMK10.66821818
81PIK3CG0.66545678
82ERBB30.66441746
83SGK10.65750850
84PHKG20.64829382
85PHKG10.64829382
86CSNK1G10.62551863
87STK110.62474986
88PIK3CA0.61829442
89STK380.60038431
90EIF2AK30.60002269
91DYRK1A0.57947966
92PDK10.57635947
93BCR0.57465208
94MAPK70.56932868
95RET0.56117478
96MAPK120.55917420
97PDPK10.53891353
98PRKCE0.53778276
99MAP3K10.53439850
100CSNK1G30.51340695
101CSNK1A1L0.50483130
102CDK30.50406877
103TAOK10.49867864
104MAP2K10.47882919
105TGFBR10.47407916
106SGK30.46748750
107GRK60.46302534
108PLK30.46156755
109CSNK1D0.45659837
110LATS20.44896276
111IRAK10.43690997
112CSNK1A10.43175457
113CAMK2D0.42746111
114PRKCH0.40525621
115PLK40.40043514
116MAP2K60.39976353
117MAP3K60.38419377
118CSNK1G20.37816877
119TEC0.37796656
120FER0.37555350
121PRKAA20.36292056
122CAMK2G0.35526229
123PAK30.34117573
124MAPKAPK50.33370799
125RPS6KA30.32815099
126PRKCZ0.31500164
127PRKG10.31293231
128ROCK20.30920259
129MARK20.30910325
130FYN0.30907117
131PRKAA10.30826328
132CAMK40.30590976
133ADRBK10.30498664
134DYRK20.30164469
135PDK30.30019421
136PDK40.30019421
137ERBB20.29807623
138MOS0.29506637
139MAP3K70.28204086
140PINK10.27870259
141PRKACA0.26500584
142FGFR20.24883969
143PRKCA0.24798477
144TNK20.24755187
145MAPK100.23698267
146PRKCB0.23672854

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.96654569
2Synaptic vesicle cycle_Homo sapiens_hsa047213.49678888
3Long-term potentiation_Homo sapiens_hsa047203.05709385
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.92362619
5Circadian entrainment_Homo sapiens_hsa047132.81498792
6Amphetamine addiction_Homo sapiens_hsa050312.70875262
7Glutamatergic synapse_Homo sapiens_hsa047242.66233661
8Olfactory transduction_Homo sapiens_hsa047402.65005291
9Morphine addiction_Homo sapiens_hsa050322.64754590
10GABAergic synapse_Homo sapiens_hsa047272.52534846
11Butanoate metabolism_Homo sapiens_hsa006502.51502156
12Salivary secretion_Homo sapiens_hsa049702.43266596
13Collecting duct acid secretion_Homo sapiens_hsa049662.29868490
14Dopaminergic synapse_Homo sapiens_hsa047282.17849540
15Renin secretion_Homo sapiens_hsa049242.07247293
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.97915430
17Insulin secretion_Homo sapiens_hsa049111.96745666
18Gastric acid secretion_Homo sapiens_hsa049711.93648504
19Taste transduction_Homo sapiens_hsa047421.88850325
20Long-term depression_Homo sapiens_hsa047301.87463724
21Nitrogen metabolism_Homo sapiens_hsa009101.86666287
22Oxytocin signaling pathway_Homo sapiens_hsa049211.85781912
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.80433971
24Cholinergic synapse_Homo sapiens_hsa047251.79470556
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.76651373
26Tryptophan metabolism_Homo sapiens_hsa003801.76233467
27Serotonergic synapse_Homo sapiens_hsa047261.75362033
28Calcium signaling pathway_Homo sapiens_hsa040201.73746594
29Linoleic acid metabolism_Homo sapiens_hsa005911.72676551
30ABC transporters_Homo sapiens_hsa020101.61290766
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.58504197
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58422757
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.48337750
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.46515647
35GnRH signaling pathway_Homo sapiens_hsa049121.46027063
36Ether lipid metabolism_Homo sapiens_hsa005651.45663252
37Gap junction_Homo sapiens_hsa045401.43027139
38Cocaine addiction_Homo sapiens_hsa050301.40693915
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39246687
40Vibrio cholerae infection_Homo sapiens_hsa051101.38575661
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.37131606
42Propanoate metabolism_Homo sapiens_hsa006401.36120391
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34612352
44Homologous recombination_Homo sapiens_hsa034401.27882283
45cAMP signaling pathway_Homo sapiens_hsa040241.23531721
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16303884
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15426465
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14032221
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13627930
50Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12998997
51Glioma_Homo sapiens_hsa052141.11875852
52Steroid hormone biosynthesis_Homo sapiens_hsa001401.10927798
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.08710440
54Fanconi anemia pathway_Homo sapiens_hsa034601.08256751
55Estrogen signaling pathway_Homo sapiens_hsa049151.07560625
56Vascular smooth muscle contraction_Homo sapiens_hsa042701.05008080
57Melanogenesis_Homo sapiens_hsa049161.03872805
58Axon guidance_Homo sapiens_hsa043601.03819025
59Selenocompound metabolism_Homo sapiens_hsa004501.03810990
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03033407
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02378123
62beta-Alanine metabolism_Homo sapiens_hsa004101.01227333
63Cardiac muscle contraction_Homo sapiens_hsa042601.01026050
64Histidine metabolism_Homo sapiens_hsa003400.99742357
65ErbB signaling pathway_Homo sapiens_hsa040120.98940681
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98485187
67Glycerolipid metabolism_Homo sapiens_hsa005610.95216498
68Phototransduction_Homo sapiens_hsa047440.93336722
69Type II diabetes mellitus_Homo sapiens_hsa049300.91700702
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90938344
71Oocyte meiosis_Homo sapiens_hsa041140.87232499
72Pancreatic secretion_Homo sapiens_hsa049720.84922399
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84572158
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83570287
75Alzheimers disease_Homo sapiens_hsa050100.81717912
76Caffeine metabolism_Homo sapiens_hsa002320.79770446
77Oxidative phosphorylation_Homo sapiens_hsa001900.79246338
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77397135
79Chemical carcinogenesis_Homo sapiens_hsa052040.77321373
80Retinol metabolism_Homo sapiens_hsa008300.77285258
81Regulation of autophagy_Homo sapiens_hsa041400.76996420
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75455749
83Basal transcription factors_Homo sapiens_hsa030220.73231807
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72668811
85Dilated cardiomyopathy_Homo sapiens_hsa054140.71072394
86Dorso-ventral axis formation_Homo sapiens_hsa043200.70949531
87VEGF signaling pathway_Homo sapiens_hsa043700.70414298
88MAPK signaling pathway_Homo sapiens_hsa040100.69656340
89Non-homologous end-joining_Homo sapiens_hsa034500.69568797
90African trypanosomiasis_Homo sapiens_hsa051430.68867549
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68772022
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67818622
93Thyroid hormone synthesis_Homo sapiens_hsa049180.66318423
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.65782540
95Peroxisome_Homo sapiens_hsa041460.63033719
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62110821
97Choline metabolism in cancer_Homo sapiens_hsa052310.62010243
98Sphingolipid metabolism_Homo sapiens_hsa006000.61299127
99Glucagon signaling pathway_Homo sapiens_hsa049220.59587484
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59016892
101Ras signaling pathway_Homo sapiens_hsa040140.58805685
102Fatty acid biosynthesis_Homo sapiens_hsa000610.57269103
103Rheumatoid arthritis_Homo sapiens_hsa053230.52531565
104Rap1 signaling pathway_Homo sapiens_hsa040150.52005130
105Arachidonic acid metabolism_Homo sapiens_hsa005900.51958471
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51487584
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50873702
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.49444281
109Protein export_Homo sapiens_hsa030600.48574449
110Fatty acid degradation_Homo sapiens_hsa000710.47366504
111Circadian rhythm_Homo sapiens_hsa047100.45894140
112Inositol phosphate metabolism_Homo sapiens_hsa005620.45708982
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44445952
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.43799889
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43280191
116Vitamin B6 metabolism_Homo sapiens_hsa007500.40604242
117Parkinsons disease_Homo sapiens_hsa050120.39788106
118Mineral absorption_Homo sapiens_hsa049780.39233576
119Fatty acid metabolism_Homo sapiens_hsa012120.39120797
120Alcoholism_Homo sapiens_hsa050340.38515799
121Wnt signaling pathway_Homo sapiens_hsa043100.37583501
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.37379492
123Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36597621
124mTOR signaling pathway_Homo sapiens_hsa041500.35819286
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35452211
126Purine metabolism_Homo sapiens_hsa002300.35434363
127Non-small cell lung cancer_Homo sapiens_hsa052230.34218633
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33718422
129Prion diseases_Homo sapiens_hsa050200.33660012
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33406483
131RNA degradation_Homo sapiens_hsa030180.32373165
132Renal cell carcinoma_Homo sapiens_hsa052110.31896814
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29745770
134Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28969342
135Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28718635
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28341211
137Lysine degradation_Homo sapiens_hsa003100.28098992
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27974349
139Insulin signaling pathway_Homo sapiens_hsa049100.27216448
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26746773
141Phagosome_Homo sapiens_hsa041450.26529175
142Ovarian steroidogenesis_Homo sapiens_hsa049130.26499292
143Bile secretion_Homo sapiens_hsa049760.26283416
144Type I diabetes mellitus_Homo sapiens_hsa049400.26150452
145Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25584260
146Chemokine signaling pathway_Homo sapiens_hsa040620.25362606
147Endocytosis_Homo sapiens_hsa041440.25295318
148Huntingtons disease_Homo sapiens_hsa050160.25150322

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