KCNV2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This member is identified as a 'silent subunit', and it does not form homomultimers, but forms heteromultimers with several other subfamily members. Through obligatory heteromerization, it exerts a function-altering effect on other potassium channel subunits. This protein is strongly expressed in pancreas and has a weaker expression in several other tissues. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retinal rod cell development (GO:0046548)9.91127530
2protein-chromophore linkage (GO:0018298)9.87315711
3GMP metabolic process (GO:0046037)9.64842156
4positive regulation of guanylate cyclase activity (GO:0031284)9.31893953
5synapsis (GO:0007129)9.07166427
6visual perception (GO:0007601)8.78844834
7sensory perception of light stimulus (GO:0050953)8.68580046
8regulation of guanylate cyclase activity (GO:0031282)8.42952428
9regulation of meiosis I (GO:0060631)8.07295055
10male meiosis I (GO:0007141)7.90669304
11DNA methylation involved in gamete generation (GO:0043046)7.82020813
12cellular response to light stimulus (GO:0071482)7.54695571
13male meiosis (GO:0007140)7.26276256
14chromosome organization involved in meiosis (GO:0070192)7.22722434
15photoreceptor cell differentiation (GO:0046530)7.05080712
16eye photoreceptor cell differentiation (GO:0001754)7.05080712
17detection of external stimulus (GO:0009581)7.03571952
18detection of abiotic stimulus (GO:0009582)6.89196265
19retina development in camera-type eye (GO:0060041)6.50212781
20synaptonemal complex assembly (GO:0007130)6.46155624
21acrosome reaction (GO:0007340)6.43589613
22meiosis I (GO:0007127)6.31857642
23meiotic nuclear division (GO:0007126)6.08697229
24regulation of cGMP metabolic process (GO:0030823)5.96085012
25synaptonemal complex organization (GO:0070193)5.82260058
26DNA packaging (GO:0006323)5.74072396
27chromosome condensation (GO:0030261)5.72036534
28sperm motility (GO:0030317)5.65600379
29negative regulation of inclusion body assembly (GO:0090084)5.58175646
30resolution of meiotic recombination intermediates (GO:0000712)5.53962434
31positive regulation of cGMP biosynthetic process (GO:0030828)5.51080863
32DNA synthesis involved in DNA repair (GO:0000731)5.37690249
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.34711410
34fusion of sperm to egg plasma membrane (GO:0007342)5.29927707
35sister chromatid cohesion (GO:0007062)5.26771755
36positive regulation of meiosis (GO:0045836)5.25548623
37spermatid development (GO:0007286)5.24490921
38meiotic chromosome segregation (GO:0045132)5.21276506
39regulation of cGMP biosynthetic process (GO:0030826)5.17883991
40meiotic cell cycle process (GO:1903046)5.17821273
41microtubule depolymerization (GO:0007019)5.00102431
42receptor guanylyl cyclase signaling pathway (GO:0007168)4.93042521
43positive regulation of meiotic cell cycle (GO:0051446)4.91709397
44binding of sperm to zona pellucida (GO:0007339)4.88164154
45cellular response to radiation (GO:0071478)4.87640158
46positive regulation of cGMP metabolic process (GO:0030825)4.84849349
47nuclear pore complex assembly (GO:0051292)4.83614833
48mitotic sister chromatid cohesion (GO:0007064)4.81188711
49nonmotile primary cilium assembly (GO:0035058)4.80178795
50adaptation of signaling pathway (GO:0023058)4.76647676
51detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.76549503
52gene silencing by RNA (GO:0031047)4.66579162
53positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.50442387
54gonadal mesoderm development (GO:0007506)4.48894626
55sperm-egg recognition (GO:0035036)4.47373149
56spermatid nucleus differentiation (GO:0007289)4.29010888
57cell morphogenesis involved in neuron differentiation (GO:0048667)4.27657144
58regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.27604733
59germ cell development (GO:0007281)4.20803898
60meiotic cell cycle (GO:0051321)4.13003518
61male gamete generation (GO:0048232)4.11586955
62spermatogenesis (GO:0007283)4.11293907
63somatic hypermutation of immunoglobulin genes (GO:0016446)4.10063827
64somatic diversification of immune receptors via somatic mutation (GO:0002566)4.10063827
65sensory perception (GO:0007600)4.08904541
66estrogen biosynthetic process (GO:0006703)4.08248851
67nuclear pore organization (GO:0006999)4.06039130
68microtubule polymerization or depolymerization (GO:0031109)4.05750016
69histone H3-K9 demethylation (GO:0033169)4.05599383
70centriole replication (GO:0007099)4.05144106
71regulation of clathrin-mediated endocytosis (GO:2000369)4.02407500
72regulation of centriole replication (GO:0046599)4.01231873
73mitotic chromosome condensation (GO:0007076)3.99621591
74centriole assembly (GO:0098534)3.98807154
75histone exchange (GO:0043486)3.98140304
76plasma membrane fusion (GO:0045026)3.97825227
77oogenesis (GO:0048477)3.90824716
78gamete generation (GO:0007276)3.89549180
79regulation of voltage-gated calcium channel activity (GO:1901385)3.89493329
80response to light stimulus (GO:0009416)3.87408076
81retina layer formation (GO:0010842)3.84444929
82reciprocal DNA recombination (GO:0035825)3.82387402
83reciprocal meiotic recombination (GO:0007131)3.82387402
84single strand break repair (GO:0000012)3.80304419
85negative regulation of meiosis (GO:0045835)3.79901673
86rRNA methylation (GO:0031167)3.65830698
87regulation of DNA endoreduplication (GO:0032875)3.63859597
88sperm capacitation (GO:0048240)3.58272786
89pore complex assembly (GO:0046931)3.54869073
90neuron development (GO:0048666)3.53547636
91regulation of inclusion body assembly (GO:0090083)3.53113792
92response to pheromone (GO:0019236)3.53069686
93cell-cell recognition (GO:0009988)3.52125677
94regulation of meiotic cell cycle (GO:0051445)3.50326680
95protein targeting to Golgi (GO:0000042)3.47597109
96female gamete generation (GO:0007292)3.47456512
97CDP-diacylglycerol biosynthetic process (GO:0016024)3.47388288
98cellular process involved in reproduction in multicellular organism (GO:0022412)3.46158232
99cerebral cortex neuron differentiation (GO:0021895)3.44035613
100gene silencing (GO:0016458)3.40773126
101prenylation (GO:0097354)3.39018908
102protein prenylation (GO:0018342)3.39018908
103regulation of histone H3-K9 methylation (GO:0051570)3.37542080
104regulation of short-term neuronal synaptic plasticity (GO:0048172)3.37047293
105nucleus organization (GO:0006997)3.34425162
106establishment of protein localization to Golgi (GO:0072600)3.33688257
107positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.33030482
108regulation of meiosis (GO:0040020)3.32896475
109positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.28371670
110short-term memory (GO:0007614)3.24744397
111fertilization (GO:0009566)3.23191090
112microtubule severing (GO:0051013)3.20683531
113negative regulation of receptor-mediated endocytosis (GO:0048261)3.18813371
114CDP-diacylglycerol metabolic process (GO:0046341)3.18443915
115protein localization to synapse (GO:0035418)3.16929799
116retinoid metabolic process (GO:0001523)3.16849735
117seminiferous tubule development (GO:0072520)3.16345159
118DNA alkylation (GO:0006305)3.15770000
119DNA methylation (GO:0006306)3.15770000
120behavioral response to ethanol (GO:0048149)3.15543011
121retina homeostasis (GO:0001895)3.15525614
122peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.15306727
123regulation of centrosome duplication (GO:0010824)3.14367197
124protein polyglutamylation (GO:0018095)3.12916238
125positive regulation of sodium ion transmembrane transport (GO:1902307)3.10997820
126chromosome organization (GO:0051276)3.10496259
127chemosensory behavior (GO:0007635)3.10219947
128retrograde transport, vesicle recycling within Golgi (GO:0000301)3.09899223
129negative regulation of gene silencing (GO:0060969)3.07491665
130motile cilium assembly (GO:0044458)3.06666108
131positive regulation of neurotransmitter transport (GO:0051590)3.06083634
132rRNA modification (GO:0000154)3.05523225
133multicellular organismal reproductive process (GO:0048609)3.05288900
134regulation of centrosome cycle (GO:0046605)3.01547314
135regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.99613996
136regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.99613996
137regulation of penile erection (GO:0060405)2.98583431
138positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.98498547
139phospholipid translocation (GO:0045332)2.98235881
140lipid translocation (GO:0034204)2.98235881
141positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.97971625
142calcium ion-dependent exocytosis (GO:0017156)2.97666734
143membrane hyperpolarization (GO:0060081)2.97154959
144chromatin remodeling at centromere (GO:0031055)2.94074255
145axoneme assembly (GO:0035082)2.94005801
146diterpenoid metabolic process (GO:0016101)2.93322367
147DNA conformation change (GO:0071103)2.92000376
148CENP-A containing nucleosome assembly (GO:0034080)2.91399502
149response to histamine (GO:0034776)2.86763675
150negative regulation of meiotic cell cycle (GO:0051447)2.86515535
151mitotic metaphase plate congression (GO:0007080)2.84807486
152cilium or flagellum-dependent cell motility (GO:0001539)2.81800332
153positive regulation of cell cycle checkpoint (GO:1901978)2.80178266
154sexual reproduction (GO:0019953)2.77985220
155positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.76469854
156synaptic vesicle docking involved in exocytosis (GO:0016081)2.75225208
157left/right axis specification (GO:0070986)2.75096518
158synaptic vesicle maturation (GO:0016188)2.73600662
159terpenoid metabolic process (GO:0006721)2.68016656
160detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.65026974
161response to radiation (GO:0009314)2.64818123
162negative regulation of transcription regulatory region DNA binding (GO:2000678)2.62954364
163establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.62929565
164mitochondrion transport along microtubule (GO:0047497)2.62929565
165positive regulation of ERBB signaling pathway (GO:1901186)2.57166723
166retinol metabolic process (GO:0042572)2.55378342
167icosanoid secretion (GO:0032309)2.53528928
168arachidonic acid secretion (GO:0050482)2.53528928
169negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.52063124
170negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.50104130
171negative regulation of calcium ion transmembrane transport (GO:1903170)2.50104130
172cellular response to abiotic stimulus (GO:0071214)2.48447770
173dopamine receptor signaling pathway (GO:0007212)2.47859326
174sodium ion export (GO:0071436)2.46326920
175post-embryonic morphogenesis (GO:0009886)2.45239772
176negative regulation of cation channel activity (GO:2001258)2.43691851
177detection of chemical stimulus involved in sensory perception (GO:0050907)2.42508294
178cellular potassium ion homeostasis (GO:0030007)2.36737401
179lipoprotein transport (GO:0042953)2.32732834
180behavioral response to cocaine (GO:0048148)2.30920036
181lactate metabolic process (GO:0006089)2.29736815
182establishment of mitochondrion localization (GO:0051654)2.28708686
183regulation of rhodopsin mediated signaling pathway (GO:0022400)18.1774513
184rhodopsin mediated signaling pathway (GO:0016056)17.7873922
185retinal cone cell development (GO:0046549)15.3384395
186photoreceptor cell maintenance (GO:0045494)12.4015702
187photoreceptor cell development (GO:0042461)12.0556830
188piRNA metabolic process (GO:0034587)11.5855783
189eye photoreceptor cell development (GO:0042462)11.5038380
190detection of light stimulus involved in visual perception (GO:0050908)11.1385398
191detection of light stimulus involved in sensory perception (GO:0050962)11.1385398
192phototransduction, visible light (GO:0007603)10.6763478
193phototransduction (GO:0007602)10.6440075
194detection of visible light (GO:0009584)10.1681626
195detection of light stimulus (GO:0009583)10.0663820

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.51802378
2CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse4.45015611
3E2F7_22180533_ChIP-Seq_HELA_Human4.43006541
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.31605508
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.44084513
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.34055523
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.04264759
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.87512950
9GBX2_23144817_ChIP-Seq_PC3_Human2.73018144
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.57838343
11DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.49639493
12VDR_22108803_ChIP-Seq_LS180_Human2.45238638
13ZNF274_21170338_ChIP-Seq_K562_Hela2.42528701
14DROSHA_22980978_ChIP-Seq_HELA_Human2.39837864
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.39135657
16FUS_26573619_Chip-Seq_HEK293_Human2.36484595
17CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.30157498
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.27921198
19BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.00970084
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.96521496
21TAF15_26573619_Chip-Seq_HEK293_Human1.90842253
22POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83612312
23* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83284243
24CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.82880739
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82110562
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80548395
27KDM2B_26808549_Chip-Seq_K562_Human1.77190845
28AR_21572438_ChIP-Seq_LNCaP_Human1.77060020
29EP300_21415370_ChIP-Seq_HL-1_Mouse1.76587905
30ETV1_20927104_ChIP-Seq_GIST48_Human1.74002597
31KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.73386830
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.73206607
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.70575077
34ER_23166858_ChIP-Seq_MCF-7_Human1.70571930
35TCF4_18268006_ChIP-ChIP_LS174T_Human1.69365003
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.67675159
37* SMAD3_21741376_ChIP-Seq_HESCs_Human1.66966442
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.66506266
39* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.62987947
40REST_18959480_ChIP-ChIP_MESCs_Mouse1.60297090
41SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58455374
42POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.58160667
43TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58160667
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.57671915
45CBX2_22325352_ChIP-Seq_293T-Rex_Human1.56916115
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.56179197
47* AR_19668381_ChIP-Seq_PC3_Human1.55354784
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54337768
49CBP_20019798_ChIP-Seq_JUKART_Human1.54337768
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52181227
51MTF2_20144788_ChIP-Seq_MESCs_Mouse1.52105571
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52075757
53P53_22127205_ChIP-Seq_FIBROBLAST_Human1.51390333
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50451259
55NFYB_21822215_ChIP-Seq_K562_Human1.48868815
56REST_21632747_ChIP-Seq_MESCs_Mouse1.48626372
57PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.47001088
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46948320
59TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.46647914
60RBPJ_21746931_ChIP-Seq_IB4_Human1.44862948
61PHF8_20622853_ChIP-Seq_HELA_Human1.43962438
62RNF2_27304074_Chip-Seq_NSC_Mouse1.39984868
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39899209
64SMAD4_21799915_ChIP-Seq_A2780_Human1.38489175
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.38291171
66* SMAD3_21741376_ChIP-Seq_EPCs_Human1.37094694
67IGF1R_20145208_ChIP-Seq_DFB_Human1.36655860
68RUNX2_22187159_ChIP-Seq_PCA_Human1.35195456
69CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.34588323
70HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.34365163
71CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34134184
72BCAT_22108803_ChIP-Seq_LS180_Human1.33803880
73TBL1_22424771_ChIP-Seq_293T_Human1.33761259
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33679943
75HNFA_21074721_ChIP-Seq_CACO-2_Human1.33243036
76* P300_19829295_ChIP-Seq_ESCs_Human1.31614211
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31419584
78TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30729394
79* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30348658
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30330537
81SMC4_20622854_ChIP-Seq_HELA_Human1.29435013
82CREB1_26743006_Chip-Seq_LNCaP_Human1.26827514
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26593585
84* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26391892
85SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.25490720
86WDR5_24793694_ChIP-Seq_LNCAP_Human1.24793879
87AR_25329375_ChIP-Seq_VCAP_Human1.23155683
88TP63_19390658_ChIP-ChIP_HaCaT_Human1.22979167
89EWS_26573619_Chip-Seq_HEK293_Human1.22931657
90CBX2_27304074_Chip-Seq_ESCs_Mouse1.22581206
91RNF2_18974828_ChIP-Seq_MESCs_Mouse1.21516587
92EZH2_18974828_ChIP-Seq_MESCs_Mouse1.21516587
93* SMAD4_21741376_ChIP-Seq_EPCs_Human1.20208443
94CTCF_27219007_Chip-Seq_Bcells_Human1.20000414
95DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19278240
96NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.18418077
97NFYA_21822215_ChIP-Seq_K562_Human1.17751574
98GATA1_26923725_Chip-Seq_HPCs_Mouse1.17149392
99EGR1_19032775_ChIP-ChIP_M12_Human1.16736740
100FLI1_27457419_Chip-Seq_LIVER_Mouse1.16192525
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16078100
102* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15904470
103KDM2B_26808549_Chip-Seq_JURKAT_Human1.15587114
104* STAT3_23295773_ChIP-Seq_U87_Human1.14686990
105* ISL1_27105846_Chip-Seq_CPCs_Mouse1.14079443
106ERA_21632823_ChIP-Seq_H3396_Human1.14025294
107SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13724230
108SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13423651
109RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12404447
110JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12341182
111SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12260584
112ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11995782
113PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11257942
114CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11167902
115CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10968988
116RNF2_27304074_Chip-Seq_ESCs_Mouse1.09129802
117IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08874922
118OCT1_27270436_Chip-Seq_PROSTATE_Human1.08840799
119CBP_21632823_ChIP-Seq_H3396_Human1.08150204
120PRDM14_20953172_ChIP-Seq_ESCs_Human1.06775597
121* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05807914
122RUNX1_26923725_Chip-Seq_HPCs_Mouse1.05764617
123NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05471015
124YY1_22570637_ChIP-Seq_MALME-3M_Human1.03979098
125KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03605082
126P68_20966046_ChIP-Seq_HELA_Human1.02988070
127MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02933662
128GATA6_21074721_ChIP-Seq_CACO-2_Human1.02659714
129EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02363688
130FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.02085464
131RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01325336
132NFE2_27457419_Chip-Seq_LIVER_Mouse1.01251624
133GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.01138418
134CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00371633
135YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00369365
136EZH2_27304074_Chip-Seq_ESCs_Mouse0.99876047
137ELK4_26923725_Chip-Seq_MESODERM_Mouse0.98699028
138FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98493189
139FOXA1_25329375_ChIP-Seq_VCAP_Human0.98493189
140GATA1_19941827_ChIP-Seq_MEL_Mouse0.98345360
141AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98271597
142DPY_21335234_ChIP-Seq_ESCs_Mouse0.97662415
143SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.96079985
144PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95094455
145NANOG_18555785_Chip-Seq_ESCs_Mouse0.94591762
146RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94538296
147SOX9_26525672_Chip-Seq_HEART_Mouse0.94294850
148* SMAD4_21741376_ChIP-Seq_HESCs_Human0.93100613
149HOXB7_26014856_ChIP-Seq_BT474_Human0.93072685
150AHR_22903824_ChIP-Seq_MCF-7_Human0.92999549
151SMAD3_21741376_ChIP-Seq_ESCs_Human0.91990683
152VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91927864
153TCF4_23295773_ChIP-Seq_U87_Human0.91518987
154OCT4_19829295_ChIP-Seq_ESCs_Human0.91285371
155WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91060886
156* MYC_19829295_ChIP-Seq_ESCs_Human0.91024084
157SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90884169
158ERG_21242973_ChIP-ChIP_JURKAT_Human0.90641504
159MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90407773
160SMAD4_21741376_ChIP-Seq_ESCs_Human0.90321857
161ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89936360
162KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.89624222
163KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.89624222
164KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.89624222
165CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89528322
166GF1_26923725_Chip-Seq_HPCs_Mouse0.89528094
167LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89235317
168TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.88826250
169NCOR_22424771_ChIP-Seq_293T_Human0.88767955
170EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87310010
171PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87124478
172FOXH1_21741376_ChIP-Seq_EPCs_Human0.86889514
173TAL1_26923725_Chip-Seq_HPCs_Mouse0.86822696
174MYC_18555785_ChIP-Seq_MESCs_Mouse0.86776712
175TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86624950
176* TAF2_19829295_ChIP-Seq_ESCs_Human0.86606592
177MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.86395861
178MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.86362846
179LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84758568
180ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83980720
181SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.83189258
182* TP53_23651856_ChIP-Seq_MEFs_Mouse0.82676607

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog9.78757379
2MP0005253_abnormal_eye_physiology6.87190249
3MP0006072_abnormal_retinal_apoptosis6.47820471
4MP0008877_abnormal_DNA_methylation5.65442704
5MP0005410_abnormal_fertilization4.65382224
6MP0003950_abnormal_plasma_membrane4.14156330
7MP0001929_abnormal_gametogenesis3.90996742
8MP0005195_abnormal_posterior_eye3.89842513
9MP0008058_abnormal_DNA_repair3.63709074
10MP0003698_abnormal_male_reproductive3.56505970
11MP0001324_abnormal_eye_pigmentation3.52492560
12MP0002210_abnormal_sex_determination3.44923984
13MP0005391_vision/eye_phenotype3.34546347
14MP0002822_catalepsy3.08866132
15MP0002090_abnormal_vision3.08617204
16MP0002638_abnormal_pupillary_reflex2.75364792
17MP0002229_neurodegeneration2.66402684
18MP0001145_abnormal_male_reproductive2.62524827
19MP0010094_abnormal_chromosome_stability2.58917059
20MP0008057_abnormal_DNA_replication2.55663269
21MP0000653_abnormal_sex_gland2.47070758
22MP0005423_abnormal_somatic_nervous2.33573008
23MP0003693_abnormal_embryo_hatching2.25931435
24MP0002161_abnormal_fertility/fecundity2.03822317
25MP0003011_delayed_dark_adaptation11.0355894
26MP0005377_hearing/vestibular/ear_phenot1.97316050
27MP0003878_abnormal_ear_physiology1.97316050
28MP0001764_abnormal_homeostasis1.97172030
29MP0003077_abnormal_cell_cycle1.93452401
30MP0002752_abnormal_somatic_nervous1.90289083
31MP0003718_maternal_effect1.83402318
32MP0004957_abnormal_blastocyst_morpholog1.75507178
33MP0005670_abnormal_white_adipose1.74592401
34MP0002653_abnormal_ependyma_morphology1.61283646
35MP0001986_abnormal_taste_sensitivity1.56150005
36MP0004233_abnormal_muscle_weight1.46380448
37MP0002160_abnormal_reproductive_system1.45527437
38MP0003111_abnormal_nucleus_morphology1.43509218
39MP0004019_abnormal_vitamin_homeostasis1.37316129
40MP0002882_abnormal_neuron_morphology1.36509905
41MP0008995_early_reproductive_senescence1.34641973
42MP0008007_abnormal_cellular_replicative1.33315297
43MP0000678_abnormal_parathyroid_gland1.26724223
44MP0005174_abnormal_tail_pigmentation1.18958537
45MP0008932_abnormal_embryonic_tissue1.18221831
46MP0001502_abnormal_circadian_rhythm1.17777069
47MP0001119_abnormal_female_reproductive1.16705240
48MP0002249_abnormal_larynx_morphology1.16122040
49MP0003119_abnormal_digestive_system1.13182991
50MP0009697_abnormal_copulation1.11570240
51MP0003699_abnormal_female_reproductive1.08103256
52MP0001730_embryonic_growth_arrest1.03896203
53MP0004885_abnormal_endolymph1.03245747
54MP0001984_abnormal_olfaction1.00797542
55MP0010307_abnormal_tumor_latency0.97966617
56MP0001293_anophthalmia0.96460106
57MP0005647_abnormal_sex_gland0.95439573
58MP0000049_abnormal_middle_ear0.94095532
59MP0005197_abnormal_uvea_morphology0.93166384
60MP0002084_abnormal_developmental_patter0.92493447
61MP0003936_abnormal_reproductive_system0.91477275
62MP0002085_abnormal_embryonic_tissue0.91380269
63MP0002332_abnormal_exercise_endurance0.88182008
64MP0004197_abnormal_fetal_growth/weight/0.88153386
65MP0003937_abnormal_limbs/digits/tail_de0.87340425
66MP0004270_analgesia0.86875643
67MP0006035_abnormal_mitochondrial_morpho0.85097592
68MP0005187_abnormal_penis_morphology0.81325015
69MP0002127_abnormal_cardiovascular_syste0.80067424
70MP0005380_embryogenesis_phenotype0.79438612
71MP0001672_abnormal_embryogenesis/_devel0.79438612
72MP0003567_abnormal_fetal_cardiomyocyte0.79277415
73MP0001486_abnormal_startle_reflex0.78632774
74MP0005389_reproductive_system_phenotype0.78310336
75MP0003634_abnormal_glial_cell0.77450076
76MP0001299_abnormal_eye_distance/0.77230843
77MP0003943_abnormal_hepatobiliary_system0.76517445
78MP0001346_abnormal_lacrimal_gland0.75677047
79MP0001485_abnormal_pinna_reflex0.74997424
80MP0002233_abnormal_nose_morphology0.74495902
81MP0003861_abnormal_nervous_system0.74486774
82MP0006292_abnormal_olfactory_placode0.74298280
83MP0003935_abnormal_craniofacial_develop0.74212360
84MP0000955_abnormal_spinal_cord0.73986367
85MP0001188_hyperpigmentation0.72778744
86MP0005394_taste/olfaction_phenotype0.71251774
87MP0005499_abnormal_olfactory_system0.71251774
88MP0002282_abnormal_trachea_morphology0.67724526
89MP0004215_abnormal_myocardial_fiber0.67221536
90MP0005395_other_phenotype0.65765261
91MP0000383_abnormal_hair_follicle0.64840878
92MP0003136_yellow_coat_color0.64715697
93MP0001697_abnormal_embryo_size0.64367276
94MP0000534_abnormal_ureter_morphology0.63584088
95MP0003786_premature_aging0.61745354
96MP0002272_abnormal_nervous_system0.61418842
97MP0000350_abnormal_cell_proliferation0.59885952
98MP0008789_abnormal_olfactory_epithelium0.58395533
99MP0002095_abnormal_skin_pigmentation0.57820249
100MP0002932_abnormal_joint_morphology0.57556478
101MP0001286_abnormal_eye_development0.54699314
102MP0001963_abnormal_hearing_physiology0.50167611
103MP0003646_muscle_fatigue0.49980093
104MP0003880_abnormal_central_pattern0.49977169
105MP0002064_seizures0.48028040
106MP0004859_abnormal_synaptic_plasticity0.47841822
107MP0000465_gastrointestinal_hemorrhage0.46571239
108MP0002734_abnormal_mechanical_nocicepti0.46465494
109MP0005376_homeostasis/metabolism_phenot0.45475306
110MP0003635_abnormal_synaptic_transmissio0.44574969
111MP0009046_muscle_twitch0.41704617
112MP0005620_abnormal_muscle_contractility0.41448467
113MP0000751_myopathy0.40994294
114MP0003045_fibrosis0.39962507
115MP0004924_abnormal_behavior0.38942269
116MP0005386_behavior/neurological_phenoty0.38942269
117MP0004085_abnormal_heartbeat0.38928302
118MP0005330_cardiomyopathy0.38683946
119MP0004145_abnormal_muscle_electrophysio0.36759009
120MP0004084_abnormal_cardiac_muscle0.36754895
121MP0002067_abnormal_sensory_capabilities0.36512624
122MP0009780_abnormal_chondrocyte_physiolo0.35498906
123MP0002063_abnormal_learning/memory/cond0.35432527
124MP0004036_abnormal_muscle_relaxation0.34081559
125MP0002572_abnormal_emotion/affect_behav0.31678096
126MP0008004_abnormal_stomach_pH0.31541348
127MP0003890_abnormal_embryonic-extraembry0.30062109
128MP0005248_abnormal_Harderian_gland0.29827152
129MP0000631_abnormal_neuroendocrine_gland0.27445417
130MP0000749_muscle_degeneration0.26710297
131MP0002102_abnormal_ear_morphology0.26523027
132MP0009745_abnormal_behavioral_response0.26053326
133MP0001968_abnormal_touch/_nociception0.25679625
134MP0002972_abnormal_cardiac_muscle0.25329063
135MP0004782_abnormal_surfactant_physiolog0.25168793
136MP0005076_abnormal_cell_differentiation0.24908678
137MP0008569_lethality_at_weaning0.23312240
138MP0000026_abnormal_inner_ear0.23137390
139MP0003137_abnormal_impulse_conducting0.22681617
140MP0001915_intracranial_hemorrhage0.22123286
141MP0002697_abnormal_eye_size0.21384546
142MP0004043_abnormal_pH_regulation0.21241734
143MP0002152_abnormal_brain_morphology0.20811492
144MP0004742_abnormal_vestibular_system0.20602704
145MP0010386_abnormal_urinary_bladder0.19892334
146MP0001661_extended_life_span0.19836072
147MP0002066_abnormal_motor_capabilities/c0.19330425
148MP0004087_abnormal_muscle_fiber0.19318501
149MP0008775_abnormal_heart_ventricle0.17981522
150MP0000759_abnormal_skeletal_muscle0.17794112
151MP0010030_abnormal_orbit_morphology0.17447806
152MP0002108_abnormal_muscle_morphology0.17386051
153MP0004130_abnormal_muscle_cell0.16595344
154MP0005193_abnormal_anterior_eye0.16505105
155MP0003632_abnormal_nervous_system0.15940910
156MP0010368_abnormal_lymphatic_system0.15810831
157MP0001879_abnormal_lymphatic_vessel0.14974537
158MP0004811_abnormal_neuron_physiology0.14576803
159MP0002184_abnormal_innervation0.14034989
160MP0003252_abnormal_bile_duct0.13902849
161MP0002269_muscular_atrophy0.13427240
162MP0000778_abnormal_nervous_system0.13351578
163MP0005595_abnormal_vascular_smooth0.13346130
164MP0003633_abnormal_nervous_system0.13245792
165MP0002234_abnormal_pharynx_morphology0.13163017

Predicted human phenotypes

RankGene SetZ-score
1Abnormal rod and cone electroretinograms (HP:0008323)9.98108058
2Pigmentary retinal degeneration (HP:0001146)9.05666902
3Central scotoma (HP:0000603)9.03684457
4Dyschromatopsia (HP:0007641)8.98348207
5Chorioretinal atrophy (HP:0000533)8.81052023
6Abnormality of macular pigmentation (HP:0008002)8.18407132
7Attenuation of retinal blood vessels (HP:0007843)7.77253680
8Pendular nystagmus (HP:0012043)7.76800709
9Abolished electroretinogram (ERG) (HP:0000550)6.93489942
10* Scotoma (HP:0000575)6.48038678
11Decreased central vision (HP:0007663)6.18872521
12Type II diabetes mellitus (HP:0005978)5.76532325
13* Photophobia (HP:0000613)5.59189396
14Posterior subcapsular cataract (HP:0007787)5.33193400
15Vitreoretinal degeneration (HP:0000655)5.15002148
16Macular degeneration (HP:0000608)5.12855264
17Cone-rod dystrophy (HP:0000548)5.12259148
18Increased corneal curvature (HP:0100692)4.81960703
19Keratoconus (HP:0000563)4.81960703
20Severe visual impairment (HP:0001141)4.77756693
21Constricted visual fields (HP:0001133)4.65570956
22Choroideremia (HP:0001139)4.56486220
23Retinitis pigmentosa (HP:0000510)4.47780142
24Tubulointerstitial nephritis (HP:0001970)4.40921732
25Chromosomal breakage induced by crosslinking agents (HP:0003221)4.40380791
26Volvulus (HP:0002580)4.13431190
27Chromsome breakage (HP:0040012)4.08024956
28Decreased electroretinogram (ERG) amplitude (HP:0000654)3.63552117
29Intestinal atresia (HP:0011100)3.31468545
30Subcapsular cataract (HP:0000523)3.29632906
31Progressive visual loss (HP:0000529)3.27795908
32Supernumerary spleens (HP:0009799)3.26916512
33Congenital sensorineural hearing impairment (HP:0008527)3.06044685
34Retinal atrophy (HP:0001105)3.05430008
35Abnormality of DNA repair (HP:0003254)2.99926357
36Osteomalacia (HP:0002749)2.98431220
37Shoulder girdle muscle weakness (HP:0003547)2.93761737
38Gonadotropin excess (HP:0000837)2.90668544
39Esophageal atresia (HP:0002032)2.89156894
40Ectopic kidney (HP:0000086)2.86487162
41Abnormality of the duodenum (HP:0002246)2.85546679
42Degeneration of the lateral corticospinal tracts (HP:0002314)2.76387671
43Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.76387671
44Small intestinal stenosis (HP:0012848)2.72830286
45Duodenal stenosis (HP:0100867)2.72830286
46Rhabdomyosarcoma (HP:0002859)2.66730637
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.66495855
48Optic disc pallor (HP:0000543)2.63277304
49Oligodactyly (hands) (HP:0001180)2.62862006
50Dynein arm defect of respiratory motile cilia (HP:0012255)2.61351450
51Absent/shortened dynein arms (HP:0200106)2.61351450
52Abnormality of the phalanges of the 2nd finger (HP:0009541)2.60722115
53Rimmed vacuoles (HP:0003805)2.59724235
54Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.57642959
55Wide nasal bridge (HP:0000431)2.56174535
56Annular pancreas (HP:0001734)2.55603571
57Azoospermia (HP:0000027)2.54670280
58Abnormality of the lower motor neuron (HP:0002366)2.50061776
59Septo-optic dysplasia (HP:0100842)2.48771714
60Medulloblastoma (HP:0002885)2.48649269
61Abnormal spermatogenesis (HP:0008669)2.45669164
62Depressed nasal tip (HP:0000437)2.44981484
63Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.41679524
64Abnormality of abdominal situs (HP:0011620)2.40757877
65Abdominal situs inversus (HP:0003363)2.40757877
66Truncal obesity (HP:0001956)2.38531747
67Agnosia (HP:0010524)2.36492293
68Gait imbalance (HP:0002141)2.28586176
69Hyperkalemia (HP:0002153)2.26835682
70Congenital primary aphakia (HP:0007707)2.26582508
71Abnormality of the corticospinal tract (HP:0002492)2.26305325
72Amyotrophic lateral sclerosis (HP:0007354)2.25705424
73Meckel diverticulum (HP:0002245)2.24334079
74Aplasia/Hypoplasia of the earlobes (HP:0009906)2.22748309
75Abnormality of chromosome stability (HP:0003220)2.20050802
76Gastrointestinal atresia (HP:0002589)2.17976443
77Abnormality of the ileum (HP:0001549)2.16933420
78Abnormality of the renal collecting system (HP:0004742)2.16382212
79Abnormality of the costochondral junction (HP:0000919)2.15970863
80Increased nuchal translucency (HP:0010880)2.11971389
81Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.11728942
82Enlarged epiphyses (HP:0010580)2.11011985
83Neoplasm of striated muscle (HP:0009728)2.08791936
84Impaired vibration sensation in the lower limbs (HP:0002166)2.05205452
85Abnormal lung lobation (HP:0002101)2.03274711
86Upper motor neuron abnormality (HP:0002127)2.02796576
87Abnormality of the vocal cords (HP:0008777)2.02637472
88Abnormality of the phalanges of the 5th finger (HP:0004213)2.01325570
89Oligodactyly (HP:0012165)2.00467562
90Congenital stationary night blindness (HP:0007642)13.9499833
91Bony spicule pigmentary retinopathy (HP:0007737)12.2205948
92Absent rod-and cone-mediated responses on ERG (HP:0007688)10.4499222
93Nephronophthisis (HP:0000090)1.99797088
94Nephrogenic diabetes insipidus (HP:0009806)1.99252443
95Bell-shaped thorax (HP:0001591)1.97126184
96Abnormal ciliary motility (HP:0012262)1.96721233
97Tubulointerstitial abnormality (HP:0001969)1.95779737
98Hypergonadotropic hypogonadism (HP:0000815)1.93549379
99Ependymoma (HP:0002888)1.90652288
100Medial flaring of the eyebrow (HP:0010747)1.90625099
101Optic nerve hypoplasia (HP:0000609)1.90340913
102Abnormal respiratory motile cilium morphology (HP:0005938)1.88835755
103Abnormal respiratory epithelium morphology (HP:0012253)1.88835755
104Abnormality of the preputium (HP:0100587)1.88753103
105Infertility (HP:0000789)1.88518193
106Obsessive-compulsive behavior (HP:0000722)1.87103051
107Duplicated collecting system (HP:0000081)1.85242253
108Polar cataract (HP:0010696)1.80402099
109Abnormality of the renal medulla (HP:0100957)1.79681417
110Menstrual irregularities (HP:0000858)1.79340798
111Sloping forehead (HP:0000340)1.77796509
112Poor coordination (HP:0002370)1.74602042
113Aplasia/Hypoplasia of the sternum (HP:0006714)1.73730444
114Abnormality of the aortic arch (HP:0012303)1.73184489
115Impulsivity (HP:0100710)1.72637624
116Aplasia/Hypoplasia of the spleen (HP:0010451)1.72007867
117Delayed epiphyseal ossification (HP:0002663)1.70880523
118Abnormal respiratory motile cilium physiology (HP:0012261)1.69180349
119Sandal gap (HP:0001852)1.68040117
120Optic atrophy (HP:0000648)1.64006101
121Vaginal atresia (HP:0000148)1.54179167
122Genital tract atresia (HP:0001827)1.47559944
123Interstitial pulmonary disease (HP:0006530)1.47085511
124Dysdiadochokinesis (HP:0002075)1.42203611
125Severe Myopia (HP:0011003)1.41391228
126True hermaphroditism (HP:0010459)1.34492225
127Pancreatic fibrosis (HP:0100732)1.32558686
128Aplasia/Hypoplasia of the lens (HP:0008063)1.28610155
129Retinal detachment (HP:0000541)1.22024778
130Epileptic encephalopathy (HP:0200134)1.11581104
131Cystic liver disease (HP:0006706)1.10926266
132Left ventricular hypertrophy (HP:0001712)1.06717194
133Pancreatic cysts (HP:0001737)1.05438319
134Abnormality of the fovea (HP:0000493)1.04635952
135Truncal ataxia (HP:0002078)1.01410476
136Febrile seizures (HP:0002373)0.99928127
137Progressive cerebellar ataxia (HP:0002073)0.98345349
138Aplasia/Hypoplasia of the tongue (HP:0010295)0.97908600
139Aplasia/Hypoplasia of the fovea (HP:0008060)0.97055452
140Hypoplasia of the fovea (HP:0007750)0.97055452
141Prolonged QT interval (HP:0001657)0.94422284
142Sclerocornea (HP:0000647)0.92591631
143Broad foot (HP:0001769)0.91459019
144Chorioretinal coloboma (HP:0000567)0.91174391
145Specific learning disability (HP:0001328)0.91122764
146Genetic anticipation (HP:0003743)0.87903251
147Furrowed tongue (HP:0000221)0.87093023
148Recurrent sinusitis (HP:0011108)0.86876313
149Hypermetropia (HP:0000540)0.85977689
150Decreased testicular size (HP:0008734)0.84647056
151Visual hallucinations (HP:0002367)0.84374968
152Asthma (HP:0002099)0.84356826
153Abnormality of dental color (HP:0011073)0.82941713
154Cerebellar dysplasia (HP:0007033)0.81583746
155Syncope (HP:0001279)0.80498366
156Abnormality of midbrain morphology (HP:0002418)0.79947664
157Molar tooth sign on MRI (HP:0002419)0.79947664
158Macroorchidism (HP:0000053)0.76322927
159Abnormal EKG (HP:0003115)0.76250428
160Aplasia/Hypoplasia of the macula (HP:0008059)0.75795258
161Abnormality of the fingertips (HP:0001211)0.73821574
162Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)0.72015026
163Dysmetric saccades (HP:0000641)0.70962232
164Aplasia/Hypoplasia affecting the retina (HP:0008061)0.70349137
165* Astigmatism (HP:0000483)0.69698147
166Chronic hepatic failure (HP:0100626)0.67622370
167Anencephaly (HP:0002323)0.65429484
168Aqueductal stenosis (HP:0002410)0.65416899
169Broad-based gait (HP:0002136)0.64715163
170Short foot (HP:0001773)0.62511358
171Dental crowding (HP:0000678)0.61785155
172Postaxial hand polydactyly (HP:0001162)0.61181835
173Lymphopenia (HP:0001888)0.60970861
174Congenital hepatic fibrosis (HP:0002612)0.60805395
175Hypodontia (HP:0000668)0.60201490
176Atrial fibrillation (HP:0005110)0.59729745
177Depression (HP:0000716)0.59204115
178Gaze-evoked nystagmus (HP:0000640)0.56814185
179Hypoventilation (HP:0002791)0.56265892
180Generalized myoclonic seizures (HP:0002123)0.55090614

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.65134410
2PLK45.31001671
3ACVR1B4.09217085
4PINK13.36965622
5CDK193.20884704
6IRAK22.84242661
7TSSK62.65762189
8STK38L2.13337725
9WEE12.07319539
10GRK111.3212040
11MAP3K101.93774577
12CDC71.72818005
13CAMK1G1.68836732
14STK391.68806088
15SIK21.67657632
16ZAK1.65310392
17ADRBK11.60916194
18CDK121.59520990
19MET1.58059609
20MAPK151.54180301
21MAPK121.53423693
22MAPK71.47371210
23CAMK1D1.46251946
24PLK11.42247619
25BRD41.38975260
26DDR21.36438589
27BRAF1.35413389
28MAP3K41.31774794
29TAOK31.31095768
30MST1R1.29291460
31STK381.28598992
32HIPK21.28161506
33INSRR1.27548795
34PASK1.21194388
35MAP4K21.20936906
36SGK2231.19322312
37SGK4941.19322312
38PAK61.19218059
39KSR21.16811850
40CSNK1D1.10799367
41PRKD31.10615855
42TESK11.10136542
43ICK1.08610753
44MAP3K91.07238349
45MUSK1.05809425
46PNCK1.04977200
47CDK71.04780159
48MAP3K21.04729257
49SRPK11.04296505
50MARK11.03885418
51CHEK11.02308127
52SGK21.00164870
53ERBB20.99068117
54BMPR1B0.98673893
55RPS6KA40.98358287
56PHKG20.97144282
57PHKG10.97144282
58PRKCH0.97134383
59EPHA40.96833712
60TYRO30.95299882
61PTK2B0.94812912
62SGK30.93544510
63TLK10.93248526
64NEK10.91327055
65WNK10.87274931
66OXSR10.87123557
67PRKAA10.84643662
68BRSK10.84554432
69FRK0.84515984
70CAMK2D0.83516986
71PRKCZ0.83502297
72BRSK20.83362754
73STK30.80882446
74CAMKK10.80215847
75PRKAA20.80122648
76VRK10.79687675
77ATR0.79459738
78MYLK0.78829076
79LATS10.78308209
80MKNK20.75862959
81NEK90.75267374
82STK240.75160744
83AKT30.75002414
84BUB10.73524740
85DYRK1A0.73379442
86TAF10.73337796
87AURKA0.71722396
88PRKCB0.71678457
89TTK0.71645331
90NTRK30.71144373
91PIK3CG0.68496005
92DYRK1B0.68195223
93KSR10.67522696
94AURKB0.62074562
95DYRK30.61658353
96RPS6KA30.61608175
97PRKACG0.61448042
98CDK20.61253968
99NEK20.60558826
100CDK80.60412492
101OBSCN0.57158037
102MAP3K80.54952404
103PDGFRB0.53376197
104CAMK10.52896530
105SGK10.52106180
106CDK90.51911970
107MAP3K70.50699243
108GRK50.50685450
109SIK10.50427706
110PRKD20.50216432
111CCNB10.49615575
112RPS6KA10.48954887
113CAMK40.48827564
114GSK3B0.48421311
115STK110.47743589
116RPS6KB10.47404912
117AKT20.47404402
118CDK50.46737945
119MAP2K40.46468123
120PAK30.46099538
121PRKDC0.45957518
122MAP2K70.43551114
123MAPK140.43367161
124CLK10.42907942
125MAPK90.42294468
126PIK3CA0.42109481
127PLK20.42025029
128FES0.41313082
129MKNK10.41164822
130MAPK100.41140639
131PLK30.40739218
132CDK40.40597006
133BMX0.39887510
134CDK30.38459301
135CDK10.37597763
136SCYL20.37475543
137MAPK10.37205135
138PRKG10.36980100
139FGFR20.35662599
140PKN10.34924744
141CSNK2A20.34858410
142RAF10.34713089
143CAMK2A0.34540192
144TGFBR10.32881457
145PRKACA0.32524984
146PDK20.32261801
147PRKD10.32015031
148MINK10.30982042
149CDC42BPA0.30246833
150NEK60.28265314
151TRIM280.28094025
152CSNK1E0.27346280
153PRKCG0.25478019
154WNK40.25470451
155LMTK20.25103608
156MAPK80.24590495
157ATM0.24030096
158ALK0.22829865
159TTN0.22384331
160PRKCA0.21809067
161CHEK20.21301926
162PRKCI0.20768053
163MAPK30.20622657
164RET0.20614755
165PRKACB0.20342767
166MTOR0.19241941

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.39353969
2DNA replication_Homo sapiens_hsa030303.64713096
3Fanconi anemia pathway_Homo sapiens_hsa034603.48651595
4Non-homologous end-joining_Homo sapiens_hsa034503.27806808
5RNA transport_Homo sapiens_hsa030133.20836193
6Dorso-ventral axis formation_Homo sapiens_hsa043202.99642961
7Nucleotide excision repair_Homo sapiens_hsa034202.92033870
8Cell cycle_Homo sapiens_hsa041102.83062706
9Base excision repair_Homo sapiens_hsa034102.80083080
10Homologous recombination_Homo sapiens_hsa034402.73059226
11Basal transcription factors_Homo sapiens_hsa030222.60519502
12Oocyte meiosis_Homo sapiens_hsa041142.14336394
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.08656555
14Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.02898110
15Phototransduction_Homo sapiens_hsa0474415.8974932
16Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.97279490
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88237393
18Synaptic vesicle cycle_Homo sapiens_hsa047211.49551822
19Taste transduction_Homo sapiens_hsa047421.47377522
20Olfactory transduction_Homo sapiens_hsa047401.45090734
21RNA degradation_Homo sapiens_hsa030181.39795134
22TGF-beta signaling pathway_Homo sapiens_hsa043501.38959177
23Regulation of autophagy_Homo sapiens_hsa041401.35563064
24Spliceosome_Homo sapiens_hsa030401.23889027
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14461692
26RNA polymerase_Homo sapiens_hsa030201.12628848
27GABAergic synapse_Homo sapiens_hsa047271.11927000
28Folate biosynthesis_Homo sapiens_hsa007901.08708134
29Sulfur relay system_Homo sapiens_hsa041221.04531074
30Hedgehog signaling pathway_Homo sapiens_hsa043401.02923948
31Selenocompound metabolism_Homo sapiens_hsa004501.02660094
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01199046
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96661154
34p53 signaling pathway_Homo sapiens_hsa041150.92975237
35Circadian rhythm_Homo sapiens_hsa047100.89319687
36Retinol metabolism_Homo sapiens_hsa008300.88414363
37Cholinergic synapse_Homo sapiens_hsa047250.87361267
38Propanoate metabolism_Homo sapiens_hsa006400.84962341
39Fatty acid degradation_Homo sapiens_hsa000710.80518789
40Pyrimidine metabolism_Homo sapiens_hsa002400.80168069
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78962531
42Circadian entrainment_Homo sapiens_hsa047130.75833542
43Morphine addiction_Homo sapiens_hsa050320.75338966
44Glutamatergic synapse_Homo sapiens_hsa047240.74669273
45Dopaminergic synapse_Homo sapiens_hsa047280.74208826
46One carbon pool by folate_Homo sapiens_hsa006700.72410543
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71485367
48ABC transporters_Homo sapiens_hsa020100.69421700
49Nitrogen metabolism_Homo sapiens_hsa009100.69293108
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65479450
51Systemic lupus erythematosus_Homo sapiens_hsa053220.63487365
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63466748
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62935664
54Ribosome_Homo sapiens_hsa030100.62366141
55Basal cell carcinoma_Homo sapiens_hsa052170.61645457
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61169177
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57934184
58Serotonergic synapse_Homo sapiens_hsa047260.56709257
59Insulin secretion_Homo sapiens_hsa049110.56615113
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56067843
61Butanoate metabolism_Homo sapiens_hsa006500.56023741
62Steroid biosynthesis_Homo sapiens_hsa001000.54474804
63Notch signaling pathway_Homo sapiens_hsa043300.52072346
64Caffeine metabolism_Homo sapiens_hsa002320.51160826
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51023745
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48457950
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48070306
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47874580
69Dilated cardiomyopathy_Homo sapiens_hsa054140.47572170
70Huntingtons disease_Homo sapiens_hsa050160.47194662
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46111108
72Oxytocin signaling pathway_Homo sapiens_hsa049210.45620039
73Viral carcinogenesis_Homo sapiens_hsa052030.44945343
74Cardiac muscle contraction_Homo sapiens_hsa042600.44693088
75beta-Alanine metabolism_Homo sapiens_hsa004100.42634327
76ErbB signaling pathway_Homo sapiens_hsa040120.42613157
77Thyroid cancer_Homo sapiens_hsa052160.42225450
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41886361
79Nicotine addiction_Homo sapiens_hsa050330.41134891
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40500678
81Purine metabolism_Homo sapiens_hsa002300.39723086
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39325763
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37345127
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36393665
85Fructose and mannose metabolism_Homo sapiens_hsa000510.36273569
86Glycerolipid metabolism_Homo sapiens_hsa005610.36169890
87cAMP signaling pathway_Homo sapiens_hsa040240.35609411
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34878111
89Lysine degradation_Homo sapiens_hsa003100.34317831
90Fatty acid elongation_Homo sapiens_hsa000620.34264260
91Inositol phosphate metabolism_Homo sapiens_hsa005620.33628413
92mTOR signaling pathway_Homo sapiens_hsa041500.32470396
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32172311
94Renin secretion_Homo sapiens_hsa049240.31806346
95Small cell lung cancer_Homo sapiens_hsa052220.31052884
96Arginine and proline metabolism_Homo sapiens_hsa003300.30649736
97Arginine biosynthesis_Homo sapiens_hsa002200.30372707
98Endocytosis_Homo sapiens_hsa041440.30011988
99Gastric acid secretion_Homo sapiens_hsa049710.29874410
100Salivary secretion_Homo sapiens_hsa049700.28958500
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.28499807
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.27450606
103Glucagon signaling pathway_Homo sapiens_hsa049220.27200215
104Long-term potentiation_Homo sapiens_hsa047200.26275892
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25994774
106Type II diabetes mellitus_Homo sapiens_hsa049300.25083098
107Cocaine addiction_Homo sapiens_hsa050300.24600365
108HTLV-I infection_Homo sapiens_hsa051660.24127207
109Axon guidance_Homo sapiens_hsa043600.23172882
110N-Glycan biosynthesis_Homo sapiens_hsa005100.23082653
111Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.22739977
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22347734
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22280231
114AMPK signaling pathway_Homo sapiens_hsa041520.20880101
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20754868
116HIF-1 signaling pathway_Homo sapiens_hsa040660.20461245
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20269079
118Prostate cancer_Homo sapiens_hsa052150.20207572
119Phenylalanine metabolism_Homo sapiens_hsa003600.19760639
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.18471894
121Bile secretion_Homo sapiens_hsa049760.18390880
122Protein digestion and absorption_Homo sapiens_hsa049740.17919157
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17824655
124GnRH signaling pathway_Homo sapiens_hsa049120.16915516
125Calcium signaling pathway_Homo sapiens_hsa040200.16677316
126Amphetamine addiction_Homo sapiens_hsa050310.16628469
127Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15878834
128Biosynthesis of amino acids_Homo sapiens_hsa012300.15773913
129Pathways in cancer_Homo sapiens_hsa052000.15724988
130Tight junction_Homo sapiens_hsa045300.15632354
1312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.14696341
132Chemokine signaling pathway_Homo sapiens_hsa040620.14350929
133Alcoholism_Homo sapiens_hsa050340.14013608
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.13766737
135Metabolic pathways_Homo sapiens_hsa011000.13274892
136Insulin resistance_Homo sapiens_hsa049310.13200328
137Estrogen signaling pathway_Homo sapiens_hsa049150.12791472
138Vascular smooth muscle contraction_Homo sapiens_hsa042700.12789011
139PPAR signaling pathway_Homo sapiens_hsa033200.12399479
140Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.12271367
141Galactose metabolism_Homo sapiens_hsa000520.11959304
142Ras signaling pathway_Homo sapiens_hsa040140.11880451
143Pancreatic secretion_Homo sapiens_hsa049720.11583492
144Thyroid hormone synthesis_Homo sapiens_hsa049180.10461809
145Mineral absorption_Homo sapiens_hsa049780.10146459
146Fatty acid metabolism_Homo sapiens_hsa012120.09638592
147MAPK signaling pathway_Homo sapiens_hsa040100.09240658
148Phospholipase D signaling pathway_Homo sapiens_hsa040720.08366740
149Glioma_Homo sapiens_hsa052140.08337461
150Renal cell carcinoma_Homo sapiens_hsa052110.08095982
151Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.07759005
152mRNA surveillance pathway_Homo sapiens_hsa030150.07630566
153Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.07522486
154Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.07238818
155Fatty acid biosynthesis_Homo sapiens_hsa000610.06814831
156Choline metabolism in cancer_Homo sapiens_hsa052310.06476529
157Maturity onset diabetes of the young_Homo sapiens_hsa049500.06185032
158SNARE interactions in vesicular transport_Homo sapiens_hsa041300.06110754
159Hippo signaling pathway_Homo sapiens_hsa043900.04400906
160Insulin signaling pathway_Homo sapiens_hsa049100.04148002
161Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.03764015
162Fat digestion and absorption_Homo sapiens_hsa049750.03574999
163Carbon metabolism_Homo sapiens_hsa012000.03074268
164Wnt signaling pathway_Homo sapiens_hsa043100.02949100
165alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.02658778
166Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.02456466

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