

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 5.60027209 |
| 2 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 5.60027209 |
| 3 | modulation by symbiont of host immune response (GO:0052553) | 5.60027209 |
| 4 | positive regulation by symbiont of host defense response (GO:0052509) | 5.60027209 |
| 5 | modulation by symbiont of host defense response (GO:0052031) | 5.60027209 |
| 6 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 5.60027209 |
| 7 | microglial cell activation (GO:0001774) | 5.28898471 |
| 8 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.22041795 |
| 9 | macrophage activation involved in immune response (GO:0002281) | 5.13301124 |
| 10 | regulation of interferon-beta biosynthetic process (GO:0045357) | 4.56645077 |
| 11 | detection of molecule of bacterial origin (GO:0032490) | 3.79574172 |
| 12 | macrophage activation (GO:0042116) | 3.74444611 |
| 13 | I-kappaB phosphorylation (GO:0007252) | 3.64947455 |
| 14 | negative regulation of cell killing (GO:0031342) | 3.61731739 |
| 15 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 3.61731739 |
| 16 | neutrophil activation involved in immune response (GO:0002283) | 3.53388603 |
| 17 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.49183055 |
| 18 | response to host immune response (GO:0052572) | 3.49183055 |
| 19 | response to peptidoglycan (GO:0032494) | 3.36547206 |
| 20 | response to host (GO:0075136) | 3.31961243 |
| 21 | response to host defenses (GO:0052200) | 3.31961243 |
| 22 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 3.31961243 |
| 23 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.27566137 |
| 24 | negative regulation of granulocyte differentiation (GO:0030853) | 3.23998553 |
| 25 | cellular extravasation (GO:0045123) | 3.22572085 |
| 26 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 3.21836273 |
| 27 | positive regulation of interferon-alpha production (GO:0032727) | 3.19844933 |
| 28 | detection of other organism (GO:0098543) | 3.19825332 |
| 29 | response to muramyl dipeptide (GO:0032495) | 3.18444147 |
| 30 | myeloid cell activation involved in immune response (GO:0002275) | 3.16653098 |
| 31 | positive regulation of chemokine secretion (GO:0090197) | 3.15995919 |
| 32 | G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589) | 3.11177994 |
| 33 | detection of external biotic stimulus (GO:0098581) | 3.08849184 |
| 34 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 3.05077865 |
| 35 | regulation of interferon-alpha production (GO:0032647) | 3.03224334 |
| 36 | positive regulation of macrophage cytokine production (GO:0060907) | 3.01514608 |
| 37 | cellular response to thyroid hormone stimulus (GO:0097067) | 2.90680243 |
| 38 | granulocyte activation (GO:0036230) | 2.85295088 |
| 39 | positive regulation of antigen processing and presentation (GO:0002579) | 2.84097288 |
| 40 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 2.81459797 |
| 41 | neutrophil activation (GO:0042119) | 2.80524406 |
| 42 | respiratory burst (GO:0045730) | 2.80045082 |
| 43 | cell adhesion mediated by integrin (GO:0033627) | 2.75969097 |
| 44 | production of molecular mediator involved in inflammatory response (GO:0002532) | 2.75918267 |
| 45 | positive regulation of B cell differentiation (GO:0045579) | 2.75740050 |
| 46 | positive regulation of cellular amide metabolic process (GO:0034250) | 2.75048842 |
| 47 | negative regulation of erythrocyte differentiation (GO:0045647) | 2.73562180 |
| 48 | detection of biotic stimulus (GO:0009595) | 2.73509095 |
| 49 | immunoglobulin mediated immune response (GO:0016064) | 2.70800193 |
| 50 | detection of bacterium (GO:0016045) | 2.68609309 |
| 51 | regulation of mast cell degranulation (GO:0043304) | 2.66861366 |
| 52 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 2.65454316 |
| 53 | positive regulation of mast cell degranulation (GO:0043306) | 2.65454316 |
| 54 | germinal center formation (GO:0002467) | 2.63615590 |
| 55 | regulation of tolerance induction (GO:0002643) | 2.62282672 |
| 56 | neutrophil chemotaxis (GO:0030593) | 2.61275767 |
| 57 | positive regulation of heat generation (GO:0031652) | 2.61192277 |
| 58 | B cell receptor signaling pathway (GO:0050853) | 2.61011142 |
| 59 | positive regulation of myeloid leukocyte mediated immunity (GO:0002888) | 2.59823320 |
| 60 | regulation of macrophage cytokine production (GO:0010935) | 2.58261343 |
| 61 | phagocytosis, engulfment (GO:0006911) | 2.57915603 |
| 62 | germ cell migration (GO:0008354) | 2.55797853 |
| 63 | G-protein coupled purinergic receptor signaling pathway (GO:0035588) | 2.54955777 |
| 64 | cellular response to ethanol (GO:0071361) | 2.53981639 |
| 65 | neutrophil migration (GO:1990266) | 2.53820907 |
| 66 | positive regulation of gamma-delta T cell activation (GO:0046645) | 2.52700663 |
| 67 | T-helper 1 type immune response (GO:0042088) | 2.52548635 |
| 68 | positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:0061081 | 2.52476615 |
| 69 | positive regulation of receptor recycling (GO:0001921) | 2.50381000 |
| 70 | regulation of mast cell activation involved in immune response (GO:0033006) | 2.48971083 |
| 71 | regulation of leukocyte degranulation (GO:0043300) | 2.48626125 |
| 72 | positive regulation of chemokine production (GO:0032722) | 2.48576171 |
| 73 | myeloid leukocyte activation (GO:0002274) | 2.46676247 |
| 74 | positive regulation of mast cell activation (GO:0033005) | 2.45744083 |
| 75 | regulation of fever generation (GO:0031620) | 2.45227244 |
| 76 | negative regulation of interleukin-6 production (GO:0032715) | 2.45017034 |
| 77 | regulation of macrophage chemotaxis (GO:0010758) | 2.44460980 |
| 78 | negative regulation of interleukin-17 production (GO:0032700) | 2.44122196 |
| 79 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 2.43747064 |
| 80 | positive regulation of chemokine biosynthetic process (GO:0045080) | 2.42278516 |
| 81 | myeloid dendritic cell differentiation (GO:0043011) | 2.39528810 |
| 82 | positive regulation of interferon-gamma biosynthetic process (GO:0045078) | 2.39374518 |
| 83 | keratan sulfate catabolic process (GO:0042340) | 2.37978364 |
| 84 | protein localization to endosome (GO:0036010) | 2.37692348 |
| 85 | positive regulation of tolerance induction (GO:0002645) | 2.37510785 |
| 86 | positive regulation of type 2 immune response (GO:0002830) | 2.36411447 |
| 87 | granulocyte chemotaxis (GO:0071621) | 2.36066022 |
| 88 | regulation of T-helper 2 cell differentiation (GO:0045628) | 2.35750743 |
| 89 | glycosphingolipid catabolic process (GO:0046479) | 2.34241287 |
| 90 | regulation of myeloid leukocyte mediated immunity (GO:0002886) | 2.33237511 |
| 91 | regulation of B cell differentiation (GO:0045577) | 2.33187228 |
| 92 | substrate-dependent cell migration (GO:0006929) | 2.32594861 |
| 93 | regulation of T cell tolerance induction (GO:0002664) | 2.32594763 |
| 94 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 2.32429540 |
| 95 | regulation of mast cell activation (GO:0033003) | 2.31508569 |
| 96 | myeloid dendritic cell activation (GO:0001773) | 2.31281841 |
| 97 | regulation of gamma-delta T cell activation (GO:0046643) | 2.29315018 |
| 98 | neutrophil mediated immunity (GO:0002446) | 2.28415359 |
| 99 | regulation of mononuclear cell migration (GO:0071675) | 2.27283029 |
| 100 | monocyte chemotaxis (GO:0002548) | 2.26706595 |
| 101 | positive regulation of leukocyte degranulation (GO:0043302) | 2.26516917 |
| 102 | granulocyte migration (GO:0097530) | 2.25665557 |
| 103 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 2.24850959 |
| 104 | barbed-end actin filament capping (GO:0051016) | 2.24632382 |
| 105 | clathrin coat assembly (GO:0048268) | 2.24009237 |
| 106 | positive regulation of interferon-beta production (GO:0032728) | 2.22354269 |
| 107 | B cell homeostasis (GO:0001782) | 2.21736738 |
| 108 | negative regulation of toll-like receptor 4 signaling pathway (GO:0034144) | 2.21035482 |
| 109 | positive regulation of tumor necrosis factor biosynthetic process (GO:0042535) | 2.20955828 |
| 110 | regulation of antigen processing and presentation (GO:0002577) | 2.20047422 |
| 111 | regulation of interleukin-8 biosynthetic process (GO:0045414) | 2.19310554 |
| 112 | cytokine secretion (GO:0050663) | 2.19147675 |
| 113 | interferon-gamma-mediated signaling pathway (GO:0060333) | 2.18317213 |
| 114 | leukocyte aggregation (GO:0070486) | 2.18174116 |
| 115 | regulation of regulated secretory pathway (GO:1903305) | 2.18108775 |
| 116 | endothelium development (GO:0003158) | 2.17175024 |
| 117 | monocyte differentiation (GO:0030224) | 2.16116213 |
| 118 | ruffle organization (GO:0031529) | 2.15516683 |
| 119 | apoptotic cell clearance (GO:0043277) | 2.15297407 |
| 120 | oligosaccharide catabolic process (GO:0009313) | 2.15069228 |
| 121 | positive regulation of interleukin-1 beta secretion (GO:0050718) | 2.15039092 |
| 122 | leukocyte cell-cell adhesion (GO:0007159) | 2.13632683 |
| 123 | cortical actin cytoskeleton organization (GO:0030866) | 2.13485818 |
| 124 | chondroitin sulfate catabolic process (GO:0030207) | 2.13481642 |
| 125 | pinocytosis (GO:0006907) | 2.13407772 |
| 126 | regulation of extracellular matrix disassembly (GO:0010715) | 2.13333772 |
| 127 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 2.13322471 |
| 128 | regulation of type 2 immune response (GO:0002828) | 2.13241633 |
| 129 | negative regulation of interleukin-12 production (GO:0032695) | 2.11991935 |
| 130 | adenosine receptor signaling pathway (GO:0001973) | 2.11917943 |
| 131 | response to laminar fluid shear stress (GO:0034616) | 2.11881958 |
| 132 | positive regulation of membrane protein ectodomain proteolysis (GO:0051044) | 2.09369578 |
| 133 | glycolipid catabolic process (GO:0019377) | 2.08255777 |
| 134 | peptide catabolic process (GO:0043171) | 2.06859124 |
| 135 | antigen processing and presentation of endogenous antigen (GO:0019883) | 2.06600246 |
| 136 | fibril organization (GO:0097435) | 2.05771576 |
| 137 | positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557) | 2.04573750 |
| 138 | hydrogen peroxide biosynthetic process (GO:0050665) | 2.04280941 |
| 139 | virion attachment to host cell (GO:0019062) | 2.02906068 |
| 140 | adhesion of symbiont to host cell (GO:0044650) | 2.02906068 |
| 141 | amino sugar catabolic process (GO:0046348) | 2.02871240 |
| 142 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 2.02489232 |
| 143 | regulation of beta-amyloid formation (GO:1902003) | 2.00379606 |
| 144 | negative regulation of cytokine production involved in immune response (GO:0002719) | 2.00365277 |
| 145 | regulation of nitric-oxide synthase biosynthetic process (GO:0051769) | 1.99359350 |
| 146 | regulation of germinal center formation (GO:0002634) | 1.99209617 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 3.76522339 |
| 2 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 3.68614182 |
| 3 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 3.26658918 |
| 4 | * SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.15587413 |
| 5 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.99332813 |
| 6 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.96093902 |
| 7 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.88109011 |
| 8 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.85947307 |
| 9 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.78407606 |
| 10 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 2.73087682 |
| 11 | * NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.47137689 |
| 12 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.24757922 |
| 13 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 2.01467653 |
| 14 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.99173066 |
| 15 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.96416847 |
| 16 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.89628997 |
| 17 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.84098029 |
| 18 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.84042125 |
| 19 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.83578895 |
| 20 | * MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.79310223 |
| 21 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.76815708 |
| 22 | SPI1_23127762_ChIP-Seq_K562_Human | 1.73366026 |
| 23 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.61879899 |
| 24 | * PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.53345908 |
| 25 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.51969297 |
| 26 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.51857484 |
| 27 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.51550649 |
| 28 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.50369163 |
| 29 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.45610199 |
| 30 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.45467438 |
| 31 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.43281671 |
| 32 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.39633798 |
| 33 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.39127404 |
| 34 | * VDR_24763502_ChIP-Seq_THP-1_Human | 1.37700452 |
| 35 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.35013241 |
| 36 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.34950266 |
| 37 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.34281790 |
| 38 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.33577816 |
| 39 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.33154642 |
| 40 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.32754058 |
| 41 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.31474818 |
| 42 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.31329586 |
| 43 | * TCF7_22412390_ChIP-Seq_EML_Mouse | 1.29484381 |
| 44 | GATA1_22025678_ChIP-Seq_K562_Human | 1.24615181 |
| 45 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.24317297 |
| 46 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.21698654 |
| 47 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.21531983 |
| 48 | * PU_27001747_Chip-Seq_BMDM_Mouse | 1.19984294 |
| 49 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 1.19379749 |
| 50 | * SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.18382553 |
| 51 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.18049655 |
| 52 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.16967791 |
| 53 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 1.15426450 |
| 54 | TP53_16413492_ChIP-PET_HCT116_Human | 1.14783492 |
| 55 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 1.14713089 |
| 56 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 1.14713089 |
| 57 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.13921102 |
| 58 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.12622955 |
| 59 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.11596479 |
| 60 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.11373942 |
| 61 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.11062929 |
| 62 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.10861803 |
| 63 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.08591681 |
| 64 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.08379440 |
| 65 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 1.08149074 |
| 66 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.06296848 |
| 67 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 1.06105333 |
| 68 | * TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.04509055 |
| 69 | * CJUN_26792858_Chip-Seq_BT549_Human | 1.02896894 |
| 70 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.01928537 |
| 71 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.00118638 |
| 72 | * MTF2_20144788_ChIP-Seq_MESCs_Mouse | 0.99995424 |
| 73 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.99538961 |
| 74 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 0.99340750 |
| 75 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 0.98928381 |
| 76 | * TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.98903759 |
| 77 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 0.98839939 |
| 78 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.98724105 |
| 79 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.98724105 |
| 80 | KDM2B_26808549_Chip-Seq_K562_Human | 0.98004502 |
| 81 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 0.97138646 |
| 82 | * JARID2_20064375_ChIP-Seq_MESCs_Mouse | 0.96750376 |
| 83 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.96686471 |
| 84 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.96499850 |
| 85 | * PPARG_20176806_ChIP-Seq_3T3-L1_Mouse | 0.96134442 |
| 86 | * TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.95985651 |
| 87 | TP53_18474530_ChIP-ChIP_U2OS_Human | 0.95895539 |
| 88 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.95892413 |
| 89 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.95615465 |
| 90 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 0.95339098 |
| 91 | RXR_22108803_ChIP-Seq_LS180_Human | 0.95131257 |
| 92 | * RNF2_18974828_ChIP-Seq_MESCs_Mouse | 0.94961596 |
| 93 | * EZH2_18974828_ChIP-Seq_MESCs_Mouse | 0.94961596 |
| 94 | CLOCK_20551151_ChIP-Seq_293T_Human | 0.93962249 |
| 95 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.93254463 |
| 96 | MYB_26560356_Chip-Seq_TH2_Human | 0.92739539 |
| 97 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.90852684 |
| 98 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 0.90472447 |
| 99 | * SOX2_20726797_ChIP-Seq_SW620_Human | 0.89502499 |
| 100 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.89259750 |
| 101 | GATA2_19941826_ChIP-Seq_K562_Human | 0.88146319 |
| 102 | GATA1_19941826_ChIP-Seq_K562_Human | 0.87997969 |
| 103 | * TP63_23658742_ChIP-Seq_EP156T_Human | 0.87768042 |
| 104 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.86343453 |
| 105 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 0.86307221 |
| 106 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.86163502 |
| 107 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 0.85850225 |
| 108 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 0.85798872 |
| 109 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.85781009 |
| 110 | MAF_26560356_Chip-Seq_TH1_Human | 0.85404060 |
| 111 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.85228117 |
| 112 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.85055354 |
| 113 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.84641672 |
| 114 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.84608531 |
| 115 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 0.84079544 |
| 116 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.83868543 |
| 117 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 0.83458076 |
| 118 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.83380868 |
| 119 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.83073739 |
| 120 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.81276268 |
| 121 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.78830802 |
| 122 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.77582515 |
| 123 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 0.77089706 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003303_peritoneal_inflammation | 4.23076751 |
| 2 | MP0000569_abnormal_digit_pigmentation | 3.99363150 |
| 3 | MP0001835_abnormal_antigen_presentation | 3.34383674 |
| 4 | MP0006082_CNS_inflammation | 2.83260126 |
| 5 | MP0003436_decreased_susceptibility_to | 2.80396818 |
| 6 | MP0005058_abnormal_lysosome_morphology | 2.78080117 |
| 7 | MP0003172_abnormal_lysosome_physiology | 2.69074842 |
| 8 | MP0002419_abnormal_innate_immunity | 2.67901423 |
| 9 | MP0003191_abnormal_cellular_cholesterol | 2.52514271 |
| 10 | MP0002148_abnormal_hypersensitivity_rea | 2.43067737 |
| 11 | MP0004510_myositis | 2.41110758 |
| 12 | MP0005000_abnormal_immune_tolerance | 2.35070207 |
| 13 | MP0002452_abnormal_antigen_presenting | 2.21666997 |
| 14 | MP0002254_reproductive_system_inflammat | 2.16975917 |
| 15 | MP0003300_gastrointestinal_ulcer | 2.16538378 |
| 16 | MP0001790_abnormal_immune_system | 2.04698014 |
| 17 | MP0005387_immune_system_phenotype | 2.04698014 |
| 18 | MP0001533_abnormal_skeleton_physiology | 2.02260336 |
| 19 | MP0008004_abnormal_stomach_pH | 2.02182582 |
| 20 | MP0009278_abnormal_bone_marrow | 2.01992483 |
| 21 | MP0005464_abnormal_platelet_physiology | 2.01799850 |
| 22 | MP0001800_abnormal_humoral_immune | 2.00047528 |
| 23 | MP0005671_abnormal_response_to | 1.95798820 |
| 24 | MP0005076_abnormal_cell_differentiation | 1.95010460 |
| 25 | MP0002723_abnormal_immune_serum | 1.88007750 |
| 26 | MP0005025_abnormal_response_to | 1.81165948 |
| 27 | MP0003075_altered_response_to | 1.80665439 |
| 28 | MP0003690_abnormal_glial_cell | 1.80569271 |
| 29 | MP0010368_abnormal_lymphatic_system | 1.78370449 |
| 30 | MP0001819_abnormal_immune_cell | 1.75453301 |
| 31 | MP0003828_pulmonary_edema | 1.74427349 |
| 32 | MP0002420_abnormal_adaptive_immunity | 1.73086072 |
| 33 | MP0003724_increased_susceptibility_to | 1.72688211 |
| 34 | MP0009785_altered_susceptibility_to | 1.68808905 |
| 35 | MP0001851_eye_inflammation | 1.68537747 |
| 36 | MP0002998_abnormal_bone_remodeling | 1.68471724 |
| 37 | MP0003183_abnormal_peptide_metabolism | 1.58374745 |
| 38 | MP0000685_abnormal_immune_system | 1.57334606 |
| 39 | MP0001542_abnormal_bone_strength | 1.56344439 |
| 40 | MP0003045_fibrosis | 1.52441868 |
| 41 | MP0004947_skin_inflammation | 1.49459185 |
| 42 | MP0001853_heart_inflammation | 1.48930025 |
| 43 | MP0005167_abnormal_blood-brain_barrier | 1.47075015 |
| 44 | MP0000604_amyloidosis | 1.45138809 |
| 45 | MP0002006_tumorigenesis | 1.43705041 |
| 46 | MP0005503_abnormal_tendon_morphology | 1.42637142 |
| 47 | MP0002166_altered_tumor_susceptibility | 1.42134219 |
| 48 | MP0000343_altered_response_to | 1.41779523 |
| 49 | MP0003448_altered_tumor_morphology | 1.40059035 |
| 50 | MP0010234_abnormal_vibrissa_follicle | 1.36431259 |
| 51 | MP0005166_decreased_susceptibility_to | 1.34626483 |
| 52 | MP0005174_abnormal_tail_pigmentation | 1.32269677 |
| 53 | MP0002405_respiratory_system_inflammati | 1.32235953 |
| 54 | MP0004859_abnormal_synaptic_plasticity | 1.31907445 |
| 55 | MP0003566_abnormal_cell_adhesion | 1.29613057 |
| 56 | MP0000767_abnormal_smooth_muscle | 1.29091712 |
| 57 | MP0001845_abnormal_inflammatory_respons | 1.27719008 |
| 58 | MP0005409_darkened_coat_color | 1.22500297 |
| 59 | MP0005595_abnormal_vascular_smooth | 1.21592552 |
| 60 | MP0005165_increased_susceptibility_to | 1.19879336 |
| 61 | MP0000716_abnormal_immune_system | 1.14981581 |
| 62 | MP0003705_abnormal_hypodermis_morpholog | 1.14326975 |
| 63 | MP0005390_skeleton_phenotype | 1.12042948 |
| 64 | MP0002332_abnormal_exercise_endurance | 1.10263967 |
| 65 | MP0000465_gastrointestinal_hemorrhage | 1.10131284 |
| 66 | MP0003329_amyloid_beta_deposits | 1.09665515 |
| 67 | MP0004484_altered_response_of | 1.08041144 |
| 68 | MP0010352_gastrointestinal_tract_polyps | 1.07475160 |
| 69 | MP0005397_hematopoietic_system_phenotyp | 1.06390184 |
| 70 | MP0001545_abnormal_hematopoietic_system | 1.06390184 |
| 71 | MP0005388_respiratory_system_phenotype | 1.05010570 |
| 72 | MP0002133_abnormal_respiratory_system | 1.05010570 |
| 73 | MP0003091_abnormal_cell_migration | 1.03467696 |
| 74 | MP0010155_abnormal_intestine_physiology | 1.02538701 |
| 75 | MP0008438_abnormal_cutaneous_collagen | 1.02252972 |
| 76 | MP0002398_abnormal_bone_marrow | 1.01454983 |
| 77 | MP0009764_decreased_sensitivity_to | 1.00741170 |
| 78 | MP0005310_abnormal_salivary_gland | 0.99303948 |
| 79 | MP0004272_abnormal_basement_membrane | 0.99245829 |
| 80 | MP0004130_abnormal_muscle_cell | 0.98165924 |
| 81 | MP0002928_abnormal_bile_duct | 0.97252809 |
| 82 | MP0003453_abnormal_keratinocyte_physiol | 0.95427781 |
| 83 | MP0005023_abnormal_wound_healing | 0.95083341 |
| 84 | MP0004858_abnormal_nervous_system | 0.95079408 |
| 85 | MP0000013_abnormal_adipose_tissue | 0.94727603 |
| 86 | MP0008469_abnormal_protein_level | 0.93225842 |
| 87 | MP0009840_abnormal_foam_cell | 0.92267195 |
| 88 | MP0002877_abnormal_melanocyte_morpholog | 0.90712836 |
| 89 | MP0000858_altered_metastatic_potential | 0.89116149 |
| 90 | MP0005275_abnormal_skin_tensile | 0.86748452 |
| 91 | MP0002933_joint_inflammation | 0.86606470 |
| 92 | MP0005257_abnormal_intraocular_pressure | 0.84842524 |
| 93 | MP0003279_aneurysm | 0.84505572 |
| 94 | MP0004883_abnormal_blood_vessel | 0.84333912 |
| 95 | MP0000689_abnormal_spleen_morphology | 0.83965761 |
| 96 | MP0006054_spinal_hemorrhage | 0.83631429 |
| 97 | MP0002168_other_aberrant_phenotype | 0.83039982 |
| 98 | MP0002090_abnormal_vision | 0.80707660 |
| 99 | MP0005164_abnormal_response_to | 0.80440330 |
| 100 | MP0002429_abnormal_blood_cell | 0.80313452 |
| 101 | MP0001879_abnormal_lymphatic_vessel | 0.79318064 |
| 102 | MP0005248_abnormal_Harderian_gland | 0.78442293 |
| 103 | MP0002971_abnormal_brown_adipose | 0.78420492 |
| 104 | MP0000249_abnormal_blood_vessel | 0.78346438 |
| 105 | MP0008961_abnormal_basal_metabolism | 0.77454051 |
| 106 | MP0004808_abnormal_hematopoietic_stem | 0.76001059 |
| 107 | MP0004084_abnormal_cardiac_muscle | 0.74906668 |
| 108 | MP0003795_abnormal_bone_structure | 0.74760353 |
| 109 | MP0002396_abnormal_hematopoietic_system | 0.74634260 |
| 110 | MP0003634_abnormal_glial_cell | 0.74623934 |
| 111 | MP0001958_emphysema | 0.72945617 |
| 112 | MP0004036_abnormal_muscle_relaxation | 0.72439801 |
| 113 | MP0002295_abnormal_pulmonary_circulatio | 0.72326853 |
| 114 | MP0002722_abnormal_immune_system | 0.71916653 |
| 115 | MP0009115_abnormal_fat_cell | 0.71686339 |
| 116 | MP0009384_cardiac_valve_regurgitation | 0.69766066 |
| 117 | MP0001873_stomach_inflammation | 0.69343475 |
| 118 | MP0001915_intracranial_hemorrhage | 0.69229931 |
| 119 | MP0000733_abnormal_muscle_development | 0.67000240 |
| 120 | MP0003633_abnormal_nervous_system | 0.66581043 |
| 121 | MP0010307_abnormal_tumor_latency | 0.66284664 |
| 122 | MP0000920_abnormal_myelination | 0.66257102 |
| 123 | MP0003879_abnormal_hair_cell | 0.66105946 |
| 124 | MP0004185_abnormal_adipocyte_glucose | 0.64169935 |
| 125 | MP0005367_renal/urinary_system_phenotyp | 0.63051980 |
| 126 | MP0000516_abnormal_urinary_system | 0.63051980 |
| 127 | MP0002896_abnormal_bone_mineralization | 0.62399546 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Recurrent abscess formation (HP:0002722) | 5.23808799 |
| 2 | Systemic lupus erythematosus (HP:0002725) | 5.06294816 |
| 3 | Recurrent bacterial skin infections (HP:0005406) | 5.06147524 |
| 4 | Eczematoid dermatitis (HP:0000976) | 4.51699289 |
| 5 | Increased cerebral lipofuscin (HP:0011813) | 4.37219550 |
| 6 | Disinhibition (HP:0000734) | 4.04039329 |
| 7 | Arterial tortuosity (HP:0005116) | 3.97115577 |
| 8 | Glomerulonephritis (HP:0000099) | 3.83772383 |
| 9 | Hematochezia (HP:0002573) | 3.78233467 |
| 10 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 3.77657935 |
| 11 | Mutism (HP:0002300) | 3.66354323 |
| 12 | Abnormality of glycolipid metabolism (HP:0010969) | 3.64484038 |
| 13 | Abnormality of liposaccharide metabolism (HP:0010968) | 3.64484038 |
| 14 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 3.64484038 |
| 15 | Recurrent gram-negative bacterial infections (HP:0005420) | 3.49891498 |
| 16 | Vascular tortuosity (HP:0004948) | 3.46687715 |
| 17 | Cerebral aneurysm (HP:0004944) | 3.34810267 |
| 18 | Dysostosis multiplex (HP:0000943) | 3.07470735 |
| 19 | Mediastinal lymphadenopathy (HP:0100721) | 3.01027475 |
| 20 | Recurrent skin infections (HP:0001581) | 2.88407093 |
| 21 | Abnormality of macrophages (HP:0004311) | 2.84167639 |
| 22 | Inappropriate behavior (HP:0000719) | 2.73075935 |
| 23 | Colitis (HP:0002583) | 2.71351564 |
| 24 | Gingivitis (HP:0000230) | 2.70423741 |
| 25 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 2.69717082 |
| 26 | Cellulitis (HP:0100658) | 2.68128842 |
| 27 | Aortic aneurysm (HP:0004942) | 2.62493149 |
| 28 | Neurofibrillary tangles (HP:0002185) | 2.62407765 |
| 29 | Peritonitis (HP:0002586) | 2.53611877 |
| 30 | Loss of speech (HP:0002371) | 2.53431061 |
| 31 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 2.51263472 |
| 32 | Abnormality of the nasal mucosa (HP:0000433) | 2.51116225 |
| 33 | Mucopolysacchariduria (HP:0008155) | 2.50510261 |
| 34 | Urinary glycosaminoglycan excretion (HP:0003541) | 2.50510261 |
| 35 | Stomatitis (HP:0010280) | 2.49753097 |
| 36 | Axonal loss (HP:0003447) | 2.48780508 |
| 37 | Recurrent fungal infections (HP:0002841) | 2.46449497 |
| 38 | Papilledema (HP:0001085) | 2.46096406 |
| 39 | Thick nail (HP:0001805) | 2.42887664 |
| 40 | Urethral obstruction (HP:0000796) | 2.41525634 |
| 41 | Asymmetric septal hypertrophy (HP:0001670) | 2.40887637 |
| 42 | Absent frontal sinuses (HP:0002688) | 2.39453756 |
| 43 | Spondylolisthesis (HP:0003302) | 2.38429094 |
| 44 | Vacuolated lymphocytes (HP:0001922) | 2.37894706 |
| 45 | Complement deficiency (HP:0004431) | 2.37889243 |
| 46 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 2.36015744 |
| 47 | Abnormality of polysaccharide metabolism (HP:0011012) | 2.36015744 |
| 48 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 2.36015744 |
| 49 | Interstitial pulmonary disease (HP:0006530) | 2.35761321 |
| 50 | Obstructive lung disease (HP:0006536) | 2.32820409 |
| 51 | Chronic obstructive pulmonary disease (HP:0006510) | 2.32820409 |
| 52 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.32388133 |
| 53 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 2.32361981 |
| 54 | Neuronal loss in central nervous system (HP:0002529) | 2.30987311 |
| 55 | Mitral valve prolapse (HP:0001634) | 2.29584929 |
| 56 | Protrusio acetabuli (HP:0003179) | 2.29339593 |
| 57 | Myositis (HP:0100614) | 2.27049591 |
| 58 | Hemoptysis (HP:0002105) | 2.24444994 |
| 59 | Nuclear cataract (HP:0100018) | 2.21099894 |
| 60 | Striae distensae (HP:0001065) | 2.20750167 |
| 61 | Periodontitis (HP:0000704) | 2.20676944 |
| 62 | Disproportionate tall stature (HP:0001519) | 2.18516420 |
| 63 | Spinal cord lesions (HP:0100561) | 2.18139857 |
| 64 | Syringomyelia (HP:0003396) | 2.18139857 |
| 65 | Dilatation of the ascending aorta (HP:0005111) | 2.18103865 |
| 66 | Apathy (HP:0000741) | 2.17547772 |
| 67 | Recurrent viral infections (HP:0004429) | 2.13243578 |
| 68 | Nephritis (HP:0000123) | 2.13139049 |
| 69 | Conjunctival telangiectasia (HP:0000524) | 2.12040001 |
| 70 | Aortic dissection (HP:0002647) | 2.08987992 |
| 71 | Inflammation of the large intestine (HP:0002037) | 2.06449699 |
| 72 | Spontaneous hematomas (HP:0007420) | 2.04904490 |
| 73 | Abnormality of complement system (HP:0005339) | 2.04738855 |
| 74 | Diminished motivation (HP:0000745) | 2.02912317 |
| 75 | Mitral stenosis (HP:0001718) | 2.02570769 |
| 76 | Retinal atrophy (HP:0001105) | 2.02083148 |
| 77 | Pulmonary infiltrates (HP:0002113) | 2.01401678 |
| 78 | Osteomyelitis (HP:0002754) | 1.99084635 |
| 79 | Orchitis (HP:0100796) | 1.97472303 |
| 80 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 1.97246563 |
| 81 | Osteolytic defects of the hand bones (HP:0009699) | 1.97246563 |
| 82 | Epiphyseal dysplasia (HP:0002656) | 1.96798470 |
| 83 | Amyloidosis (HP:0011034) | 1.96260644 |
| 84 | Aneurysm (HP:0002617) | 1.95462575 |
| 85 | Keratoconjunctivitis sicca (HP:0001097) | 1.95106896 |
| 86 | Thin bony cortex (HP:0002753) | 1.93971565 |
| 87 | Recurrent cutaneous fungal infections (HP:0011370) | 1.93372423 |
| 88 | Chronic mucocutaneous candidiasis (HP:0002728) | 1.93372423 |
| 89 | Gastrointestinal infarctions (HP:0005244) | 1.92394887 |
| 90 | Polycythemia (HP:0001901) | 1.91731185 |
| 91 | Overgrowth (HP:0001548) | 1.90855173 |
| 92 | Gastrointestinal inflammation (HP:0004386) | 1.87905302 |
| 93 | Prostate neoplasm (HP:0100787) | 1.86666016 |
| 94 | Myocardial infarction (HP:0001658) | 1.85551092 |
| 95 | Agnosia (HP:0010524) | 1.85453791 |
| 96 | Esophageal varix (HP:0002040) | 1.84763625 |
| 97 | Premature rupture of membranes (HP:0001788) | 1.81882864 |
| 98 | Cerebral inclusion bodies (HP:0100314) | 1.81449169 |
| 99 | Autoimmune thrombocytopenia (HP:0001973) | 1.80868221 |
| 100 | Muscle fiber splitting (HP:0003555) | 1.80631901 |
| 101 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 1.80067835 |
| 102 | Bicuspid aortic valve (HP:0001647) | 1.79837709 |
| 103 | Transitional cell carcinoma of the bladder (HP:0006740) | 1.77675040 |
| 104 | Pathologic fracture (HP:0002756) | 1.76976014 |
| 105 | Vertebral compression fractures (HP:0002953) | 1.76909512 |
| 106 | Malnutrition (HP:0004395) | 1.75460102 |
| 107 | Keratoconjunctivitis (HP:0001096) | 1.75326814 |
| 108 | Narrow palate (HP:0000189) | 1.74368816 |
| 109 | Pulmonary artery stenosis (HP:0004415) | 1.74088178 |
| 110 | Bone pain (HP:0002653) | 1.74081995 |
| 111 | Mucosal telangiectasiae (HP:0100579) | 1.73606060 |
| 112 | Pulmonary hypertension (HP:0002092) | 1.72735977 |
| 113 | Arterial thrombosis (HP:0004420) | 1.72588521 |
| 114 | Purpura (HP:0000979) | 1.72011757 |
| 115 | Pustule (HP:0200039) | 1.71766172 |
| 116 | Basal ganglia calcification (HP:0002135) | 1.71336406 |
| 117 | Abnormality of the frontal sinuses (HP:0002687) | 1.71126581 |
| 118 | Bladder neoplasm (HP:0009725) | 1.71083158 |
| 119 | Bladder carcinoma (HP:0002862) | 1.71083158 |
| 120 | Vasculitis (HP:0002633) | 1.70389408 |
| 121 | Increased variability in muscle fiber diameter (HP:0003557) | 1.70013584 |
| 122 | Recurrent pneumonia (HP:0006532) | 1.69126244 |
| 123 | Abnormality of the periventricular white matter (HP:0002518) | 1.69057736 |
| 124 | Nasal polyposis (HP:0100582) | 1.68913893 |
| 125 | Optic neuritis (HP:0100653) | 1.68462072 |
| 126 | Retrobulbar optic neuritis (HP:0100654) | 1.68462072 |
| 127 | Gingival bleeding (HP:0000225) | 1.68396115 |
| 128 | Aplasia/Hypoplasia of the frontal sinuses (HP:0009119) | 1.67892375 |
| 129 | Absent/shortened dynein arms (HP:0200106) | 1.66616181 |
| 130 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.66616181 |
| 131 | Meningitis (HP:0001287) | 1.66409687 |
| 132 | Uterine leiomyosarcoma (HP:0002891) | 1.66393935 |
| 133 | Leiomyosarcoma (HP:0100243) | 1.66393935 |
| 134 | Pulmonary embolism (HP:0002204) | 1.65892350 |
| 135 | Increased CSF protein (HP:0002922) | 1.64970730 |
| 136 | Abnormality of binocular vision (HP:0011514) | 1.64823678 |
| 137 | Diplopia (HP:0000651) | 1.64823678 |
| 138 | Action tremor (HP:0002345) | 1.64727018 |
| 139 | Vertigo (HP:0002321) | 1.64232768 |
| 140 | Upper motor neuron abnormality (HP:0002127) | 1.63674393 |
| 141 | Subacute progressive viral hepatitis (HP:0006572) | 1.63392485 |
| 142 | Progressive neurologic deterioration (HP:0002344) | 1.61853061 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TGFBR2 | 5.30939920 |
| 2 | RIPK4 | 3.56714891 |
| 3 | MAP3K14 | 3.04516881 |
| 4 | BLK | 2.43810190 |
| 5 | CSF1R | 2.40987191 |
| 6 | TIE1 | 2.30426351 |
| 7 | MAPK15 | 2.24392579 |
| 8 | GRK7 | 2.20812462 |
| 9 | CAMK1G | 2.05544593 |
| 10 | TYK2 | 2.03051110 |
| 11 | TBK1 | 2.00349742 |
| 12 | PRPF4B | 1.98030302 |
| 13 | IRAK4 | 1.93064671 |
| 14 | CAMK1D | 1.84955160 |
| 15 | MAP3K10 | 1.69171453 |
| 16 | JAK1 | 1.61301337 |
| 17 | SIK2 | 1.61236253 |
| 18 | RIPK1 | 1.57221172 |
| 19 | FES | 1.56520395 |
| 20 | MAP4K1 | 1.54984089 |
| 21 | MAP3K13 | 1.43368974 |
| 22 | IRAK3 | 1.42137623 |
| 23 | MAP3K9 | 1.41395347 |
| 24 | DDR2 | 1.35169120 |
| 25 | HCK | 1.34569498 |
| 26 | EPHB1 | 1.29882051 |
| 27 | KIT | 1.26014434 |
| 28 | CDC42BPA | 1.24346012 |
| 29 | PTK6 | 1.23736529 |
| 30 | ERN1 | 1.19910166 |
| 31 | CLK1 | 1.18272043 |
| 32 | IKBKB | 1.17887010 |
| 33 | MAP3K1 | 1.16868700 |
| 34 | CAMKK2 | 1.14112883 |
| 35 | DMPK | 1.13802782 |
| 36 | CSK | 1.13192403 |
| 37 | STK10 | 1.12170300 |
| 38 | SYK | 1.11997685 |
| 39 | YES1 | 1.10408335 |
| 40 | SCYL2 | 1.10273367 |
| 41 | CAMKK1 | 1.09757417 |
| 42 | FER | 1.05588856 |
| 43 | JAK2 | 1.05274599 |
| 44 | TRPM7 | 1.03480635 |
| 45 | IRAK1 | 1.02769128 |
| 46 | FGFR3 | 1.02486805 |
| 47 | FGR | 1.02442087 |
| 48 | CHUK | 0.99830674 |
| 49 | ITK | 0.99462404 |
| 50 | IKBKE | 0.98930745 |
| 51 | PAK4 | 0.95477671 |
| 52 | NLK | 0.95431980 |
| 53 | MATK | 0.93371950 |
| 54 | ERBB3 | 0.93225826 |
| 55 | SGK2 | 0.93118759 |
| 56 | CDK6 | 0.92585821 |
| 57 | BMPR2 | 0.90531925 |
| 58 | TAOK1 | 0.89447325 |
| 59 | MARK2 | 0.88273021 |
| 60 | TRIB3 | 0.87586100 |
| 61 | LYN | 0.87336458 |
| 62 | BTK | 0.83059452 |
| 63 | MAPK12 | 0.82665677 |
| 64 | ZAP70 | 0.82275606 |
| 65 | EPHB2 | 0.82166558 |
| 66 | LCK | 0.81479606 |
| 67 | MOS | 0.80354720 |
| 68 | PIK3CG | 0.78073526 |
| 69 | MARK1 | 0.77316279 |
| 70 | EGFR | 0.76446312 |
| 71 | GRK5 | 0.75638627 |
| 72 | FGFR4 | 0.75058437 |
| 73 | MARK3 | 0.74090130 |
| 74 | NEK9 | 0.72670098 |
| 75 | MYLK | 0.71124944 |
| 76 | PLK2 | 0.69428632 |
| 77 | TAOK3 | 0.69124813 |
| 78 | RET | 0.69095049 |
| 79 | JAK3 | 0.67243040 |
| 80 | ABL1 | 0.66476644 |
| 81 | PDGFRB | 0.66351008 |
| 82 | FYN | 0.66181940 |
| 83 | IRAK2 | 0.66065029 |
| 84 | PDK1 | 0.64247698 |
| 85 | MAP3K2 | 0.62775915 |
| 86 | STK24 | 0.62264723 |
| 87 | GSK3A | 0.57730578 |
| 88 | SGK3 | 0.57674299 |
| 89 | MAP3K6 | 0.57408054 |
| 90 | EPHA3 | 0.57038369 |
| 91 | KSR2 | 0.56593378 |
| 92 | PKN2 | 0.55784555 |
| 93 | PTK2B | 0.54317803 |
| 94 | MAP2K3 | 0.53888782 |
| 95 | LATS2 | 0.53677772 |
| 96 | PRKAA2 | 0.53180053 |
| 97 | MINK1 | 0.51004616 |
| 98 | TTN | 0.50658770 |
| 99 | TEC | 0.50596758 |
| 100 | MAP3K11 | 0.50527396 |
| 101 | PRKD2 | 0.50283237 |
| 102 | IGF1R | 0.50120467 |
| 103 | CAMK4 | 0.49913144 |
| 104 | ALK | 0.49543743 |
| 105 | ROCK2 | 0.49122643 |
| 106 | DAPK2 | 0.48813162 |
| 107 | OBSCN | 0.48507744 |
| 108 | RPS6KA2 | 0.48444560 |
| 109 | PRKCH | 0.47893985 |
| 110 | NTRK3 | 0.47159243 |
| 111 | PRKD1 | 0.46569536 |
| 112 | STK11 | 0.46279321 |
| 113 | PAK2 | 0.45771256 |
| 114 | MAP3K7 | 0.45007464 |
| 115 | SGK494 | 0.44477284 |
| 116 | SGK223 | 0.44477284 |
| 117 | MAP3K3 | 0.44137149 |
| 118 | PDGFRA | 0.43574047 |
| 119 | KSR1 | 0.43486584 |
| 120 | MAPKAPK2 | 0.43028196 |
| 121 | NTRK1 | 0.42829283 |
| 122 | PDPK1 | 0.42613508 |
| 123 | CDK12 | 0.42010506 |
| 124 | TXK | 0.41853121 |
| 125 | INSR | 0.41823813 |
| 126 | WNK1 | 0.41730327 |
| 127 | EIF2AK2 | 0.41639339 |
| 128 | ERBB2 | 0.41069923 |
| 129 | HIPK2 | 0.40756296 |
| 130 | TGFBR1 | 0.40741085 |
| 131 | SRC | 0.40517827 |
| 132 | MAPK7 | 0.40334741 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.45625060 |
| 2 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.41734364 |
| 3 | Leishmaniasis_Homo sapiens_hsa05140 | 2.33572763 |
| 4 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 2.05128710 |
| 5 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.92987214 |
| 6 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.88388924 |
| 7 | Pertussis_Homo sapiens_hsa05133 | 1.80463862 |
| 8 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.71293104 |
| 9 | Tuberculosis_Homo sapiens_hsa05152 | 1.68980325 |
| 10 | Lysosome_Homo sapiens_hsa04142 | 1.61488510 |
| 11 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.54523919 |
| 12 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.53019446 |
| 13 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.43410813 |
| 14 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.42916899 |
| 15 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.39708265 |
| 16 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.38028041 |
| 17 | Other glycan degradation_Homo sapiens_hsa00511 | 1.34263357 |
| 18 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.32630021 |
| 19 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.32120776 |
| 20 | Allograft rejection_Homo sapiens_hsa05330 | 1.30482839 |
| 21 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.27680366 |
| 22 | Asthma_Homo sapiens_hsa05310 | 1.26899384 |
| 23 | Legionellosis_Homo sapiens_hsa05134 | 1.24924270 |
| 24 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.22128391 |
| 25 | Malaria_Homo sapiens_hsa05144 | 1.20598051 |
| 26 | Salmonella infection_Homo sapiens_hsa05132 | 1.19465582 |
| 27 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.19130500 |
| 28 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.17202743 |
| 29 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 1.16648422 |
| 30 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.15554444 |
| 31 | Phagosome_Homo sapiens_hsa04145 | 1.14393423 |
| 32 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.13054602 |
| 33 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.12521390 |
| 34 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.11604316 |
| 35 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.09848598 |
| 36 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.06737276 |
| 37 | Influenza A_Homo sapiens_hsa05164 | 1.04891514 |
| 38 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 1.04812234 |
| 39 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 1.03968510 |
| 40 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.03042917 |
| 41 | Platelet activation_Homo sapiens_hsa04611 | 1.02955301 |
| 42 | Measles_Homo sapiens_hsa05162 | 1.02595418 |
| 43 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.02315484 |
| 44 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.00356790 |
| 45 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.00149986 |
| 46 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.98322862 |
| 47 | Shigellosis_Homo sapiens_hsa05131 | 0.94082781 |
| 48 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.93919208 |
| 49 | Hepatitis B_Homo sapiens_hsa05161 | 0.93785298 |
| 50 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.93471090 |
| 51 | Amoebiasis_Homo sapiens_hsa05146 | 0.92798548 |
| 52 | Colorectal cancer_Homo sapiens_hsa05210 | 0.92213415 |
| 53 | Viral myocarditis_Homo sapiens_hsa05416 | 0.90505783 |
| 54 | Glioma_Homo sapiens_hsa05214 | 0.90167421 |
| 55 | Prion diseases_Homo sapiens_hsa05020 | 0.89862561 |
| 56 | Apoptosis_Homo sapiens_hsa04210 | 0.88741323 |
| 57 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.87523577 |
| 58 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.86440054 |
| 59 | Renin secretion_Homo sapiens_hsa04924 | 0.85457901 |
| 60 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.85168999 |
| 61 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.84773793 |
| 62 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.82930636 |
| 63 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.81514662 |
| 64 | Endocytosis_Homo sapiens_hsa04144 | 0.81473635 |
| 65 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.80679958 |
| 66 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.80469717 |
| 67 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.78758155 |
| 68 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.78362773 |
| 69 | Adherens junction_Homo sapiens_hsa04520 | 0.78110198 |
| 70 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.78088315 |
| 71 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.78056607 |
| 72 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.75225622 |
| 73 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.75157632 |
| 74 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.74571752 |
| 75 | Focal adhesion_Homo sapiens_hsa04510 | 0.73028313 |
| 76 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.72321102 |
| 77 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.71917353 |
| 78 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.70985904 |
| 79 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.69835724 |
| 80 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.69709116 |
| 81 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.68920573 |
| 82 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.68319363 |
| 83 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.67877215 |
| 84 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.67753849 |
| 85 | Long-term potentiation_Homo sapiens_hsa04720 | 0.67471936 |
| 86 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.67274663 |
| 87 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.66560298 |
| 88 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.65725941 |
| 89 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.65053303 |
| 90 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.64913625 |
| 91 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.64693972 |
| 92 | Salivary secretion_Homo sapiens_hsa04970 | 0.64261108 |
| 93 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.63583758 |
| 94 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.62939968 |
| 95 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.62746817 |
| 96 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.62705899 |
| 97 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.62372911 |
| 98 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.62078882 |
| 99 | Hepatitis C_Homo sapiens_hsa05160 | 0.61927599 |
| 100 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.61816564 |
| 101 | Olfactory transduction_Homo sapiens_hsa04740 | 0.61471335 |
| 102 | Long-term depression_Homo sapiens_hsa04730 | 0.61034325 |
| 103 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.60847162 |
| 104 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.59649178 |
| 105 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.59382644 |
| 106 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.59065506 |
| 107 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.58500271 |
| 108 | Morphine addiction_Homo sapiens_hsa05032 | 0.58407921 |
| 109 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.58095910 |
| 110 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.57888692 |
| 111 | Circadian entrainment_Homo sapiens_hsa04713 | 0.57790882 |
| 112 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.57342055 |
| 113 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.56830025 |
| 114 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.55679040 |
| 115 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.55401690 |
| 116 | Gap junction_Homo sapiens_hsa04540 | 0.54677837 |
| 117 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.53748629 |
| 118 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.51414742 |

