KCTD14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of male gonad development (GO:2000020)9.84295271
2regulation of male gonad development (GO:2000018)9.51704811
3sex determination (GO:0007530)8.68052996
4androgen biosynthetic process (GO:0006702)7.93679450
5establishment of integrated proviral latency (GO:0075713)6.58531135
6estrogen biosynthetic process (GO:0006703)6.01406994
7establishment of viral latency (GO:0019043)5.63801387
8regulation of gonadotropin secretion (GO:0032276)5.50840092
9regulation of female gonad development (GO:2000194)5.49598693
10proteasome assembly (GO:0043248)5.18465413
11Leydig cell differentiation (GO:0033327)5.12480058
12ribosome assembly (GO:0042255)4.97639577
13negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.97530579
14sex differentiation (GO:0007548)4.89276413
15male sex determination (GO:0030238)4.77251600
16regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.73402564
17cellular response to follicle-stimulating hormone stimulus (GO:0071372)4.67912784
18negative regulation of ligase activity (GO:0051352)4.51522544
19negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.51522544
20positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.49745086
21anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.43304341
22androgen metabolic process (GO:0008209)4.41589373
23cellular response to gonadotropin stimulus (GO:0071371)4.27412889
24regulation of cellular amino acid metabolic process (GO:0006521)4.23586151
25mitotic metaphase plate congression (GO:0007080)4.22286118
26positive regulation of natural killer cell differentiation (GO:0032825)4.16335704
27anatomical structure regression (GO:0060033)4.06635628
28IMP biosynthetic process (GO:0006188)4.03852863
29negative regulation of macrophage differentiation (GO:0045650)3.98150329
30metaphase plate congression (GO:0051310)3.93959510
31regulation of dendritic cell antigen processing and presentation (GO:0002604)3.93917931
32oocyte development (GO:0048599)3.93653758
33chromatin remodeling at centromere (GO:0031055)3.88270742
34CENP-A containing nucleosome assembly (GO:0034080)3.86350961
35positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.81044355
36adrenal gland development (GO:0030325)3.78322754
37cellular response to antibiotic (GO:0071236)3.77357257
38DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.77193957
39signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.74350955
40signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.74350955
41signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.74350955
42purine nucleobase biosynthetic process (GO:0009113)3.73196772
43signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.73009988
44intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.73009988
45positive regulation of ligase activity (GO:0051351)3.62923188
46signal transduction involved in DNA integrity checkpoint (GO:0072401)3.62049297
47signal transduction involved in DNA damage checkpoint (GO:0072422)3.62049297
48IMP metabolic process (GO:0046040)3.61936408
49regulation of ubiquitin-protein transferase activity (GO:0051438)3.61024147
50establishment of protein localization to mitochondrial membrane (GO:0090151)3.58573697
51regulation of interferon-gamma biosynthetic process (GO:0045072)3.57420478
52signal transduction involved in cell cycle checkpoint (GO:0072395)3.54808586
53DNA strand elongation involved in DNA replication (GO:0006271)3.54052900
54protein localization to kinetochore (GO:0034501)3.53743438
55chaperone-mediated protein transport (GO:0072321)3.52788572
56glomerular basement membrane development (GO:0032836)3.51491509
57regulation of mitochondrial translation (GO:0070129)3.50271220
58regulation of ligase activity (GO:0051340)3.46548211
59positive regulation of antigen processing and presentation (GO:0002579)3.45164868
60cullin deneddylation (GO:0010388)3.45016199
61negative regulation of mitotic sister chromatid separation (GO:2000816)3.44076098
62negative regulation of sister chromatid segregation (GO:0033046)3.44076098
63negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.44076098
64negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.44076098
65negative regulation of mitotic sister chromatid segregation (GO:0033048)3.44076098
66spindle checkpoint (GO:0031577)3.43850965
67protein maturation by protein folding (GO:0022417)3.43677528
68rRNA modification (GO:0000154)3.43516417
69glomerulus development (GO:0032835)3.43268781
70L-serine metabolic process (GO:0006563)3.40997306
71negative regulation of chromosome segregation (GO:0051985)3.38094809
72mitotic spindle checkpoint (GO:0071174)3.36105942
73DNA replication checkpoint (GO:0000076)3.35938174
74nucleotide-sugar biosynthetic process (GO:0009226)3.35159426
75DNA strand elongation (GO:0022616)3.34636867
76telomere maintenance via semi-conservative replication (GO:0032201)3.34260715
77natural killer cell differentiation (GO:0001779)3.33413465
78mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.31812076
79cellular response to interferon-alpha (GO:0035457)3.29757596
80regulation of helicase activity (GO:0051095)3.29451303
81histone exchange (GO:0043486)3.28426996
82female gonad development (GO:0008585)3.28387067
83nucleobase biosynthetic process (GO:0046112)3.27227707
84ovulation cycle (GO:0042698)3.24477808
85hormone biosynthetic process (GO:0042446)3.23969380
86DNA damage response, detection of DNA damage (GO:0042769)3.23683020
87heterochromatin organization (GO:0070828)3.23528677
88regulation of natural killer cell differentiation (GO:0032823)3.23202779
89urogenital system development (GO:0001655)3.21858873
90protein deneddylation (GO:0000338)3.21695298
91negative regulation of protein ubiquitination (GO:0031397)3.20160975
92regulation of meiosis I (GO:0060631)3.18254773
93response to follicle-stimulating hormone (GO:0032354)3.15564219
94regulation of cellular amine metabolic process (GO:0033238)3.13967191
95establishment of chromosome localization (GO:0051303)3.12097567
96mitotic spindle assembly checkpoint (GO:0007094)3.11163648
97atrioventricular valve morphogenesis (GO:0003181)3.10705185
98spliceosomal snRNP assembly (GO:0000387)3.10443350
99positive regulation of reproductive process (GO:2000243)3.10415500
100transcription elongation from RNA polymerase III promoter (GO:0006385)3.07831763
101termination of RNA polymerase III transcription (GO:0006386)3.07831763
102regulation of antigen processing and presentation (GO:0002577)3.04229295
103hemoglobin metabolic process (GO:0020027)3.04152923
104multicellular organismal aging (GO:0010259)3.03706981
105rRNA methylation (GO:0031167)3.02634092
106spindle assembly checkpoint (GO:0071173)3.02062904
107negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.01449198
108DNA replication-independent nucleosome assembly (GO:0006336)2.99294995
109DNA replication-independent nucleosome organization (GO:0034724)2.99294995
110response to X-ray (GO:0010165)2.97989624
111negative regulation of mitosis (GO:0045839)2.96977445
112regulation of mitotic metaphase/anaphase transition (GO:0030071)2.96951999
113regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.96951999
114antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.96859271
115DNA double-strand break processing (GO:0000729)2.96337307
116tRNA aminoacylation for protein translation (GO:0006418)2.95537907
117dendritic cell chemotaxis (GO:0002407)2.95232628
118estrogen metabolic process (GO:0008210)2.95214659
119regulation of spindle organization (GO:0090224)2.95106371
120cellular response to toxic substance (GO:0097237)2.93250016
121G1/S transition of mitotic cell cycle (GO:0000082)2.92307941
122cell cycle G1/S phase transition (GO:0044843)2.92307941
123DNA catabolic process, exonucleolytic (GO:0000738)2.91522360
124regulation of chromosome segregation (GO:0051983)2.89972991
125AMP metabolic process (GO:0046033)2.89397608
126cell differentiation involved in metanephros development (GO:0072202)2.88396244
127tRNA aminoacylation (GO:0043039)2.88082994
128amino acid activation (GO:0043038)2.88082994
129regulation of sister chromatid segregation (GO:0033045)2.86735788
130regulation of mitotic sister chromatid separation (GO:0010965)2.86735788
131regulation of mitotic sister chromatid segregation (GO:0033047)2.86735788
132protein targeting to mitochondrion (GO:0006626)2.86070676
133mitotic sister chromatid segregation (GO:0000070)2.83270530
134DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.82382482
135protein complex localization (GO:0031503)2.82346778
136ribosomal large subunit biogenesis (GO:0042273)2.81942094
137mesonephros development (GO:0001823)2.79710020
138regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.79575294
139positive regulation of cellular amide metabolic process (GO:0034250)2.78522459
140ventricular cardiac muscle cell development (GO:0055015)2.78086981
141regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.77677223
142regulation of mitotic spindle checkpoint (GO:1903504)2.77677223
143formation of translation preinitiation complex (GO:0001731)2.77410579
144response to interferon-alpha (GO:0035455)2.77345431
145telomere maintenance via recombination (GO:0000722)2.74462914
146ketone biosynthetic process (GO:0042181)2.74146899
147glucocorticoid biosynthetic process (GO:0006704)2.73168723
148ovulation cycle process (GO:0022602)2.72117806
149poly(A)+ mRNA export from nucleus (GO:0016973)2.66693912
150positive regulation of meiosis (GO:0045836)2.66256699
151regulation of activation of Janus kinase activity (GO:0010533)2.64780735
152Sertoli cell development (GO:0060009)2.64131161
153embryonic digestive tract morphogenesis (GO:0048557)2.63673352
154seminiferous tubule development (GO:0072520)2.63474422
155male gonad development (GO:0008584)2.63251315
156response to gonadotropin (GO:0034698)2.60755368
157histone H3-K36 demethylation (GO:0070544)2.60262634
158male genitalia development (GO:0030539)2.59426250
159astrocyte development (GO:0014002)2.58719556
160DNA integration (GO:0015074)2.58609200
161regulation of timing of cell differentiation (GO:0048505)2.57952767
162detection of bacterium (GO:0016045)2.56930473
163regulation of T-helper 1 cell differentiation (GO:0045625)2.55548433
164cornea development in camera-type eye (GO:0061303)2.55515104
165cellular response to exogenous dsRNA (GO:0071360)2.54674743
166positive regulation of meiotic cell cycle (GO:0051446)2.54290136
167protein heterotrimerization (GO:0070208)2.50973559
168negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.47871264
169nephron tubule formation (GO:0072079)2.47676586
170detection of other organism (GO:0098543)2.47416346
171daunorubicin metabolic process (GO:0044597)2.46949107
172polyketide metabolic process (GO:0030638)2.46949107
173doxorubicin metabolic process (GO:0044598)2.46949107
174negative regulation of B cell activation (GO:0050869)2.45726306
175superoxide anion generation (GO:0042554)2.44966556
176regulation of skeletal muscle contraction (GO:0014819)2.41457215
177synapsis (GO:0007129)2.40961804
178regulation of macrophage differentiation (GO:0045649)2.40602891
179mesenchymal cell differentiation involved in renal system development (GO:2001012)2.39363260
180mesenchymal cell differentiation involved in kidney development (GO:0072161)2.39363260
181regulation of B cell differentiation (GO:0045577)2.38541112
182microglial cell activation (GO:0001774)2.38304315
183natural killer cell activation (GO:0030101)2.37639574
184dendritic cell migration (GO:0036336)2.37439927
185negative regulation of reproductive process (GO:2000242)2.36688687
186ribosomal small subunit assembly (GO:0000028)2.35457201
187positive regulation of interleukin-17 production (GO:0032740)2.35332292
188negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.34156081
189T-helper 1 type immune response (GO:0042088)2.33836498
190regulation of neutrophil migration (GO:1902622)2.33527596
191regulation of neutrophil chemotaxis (GO:0090022)2.33527596
192piRNA metabolic process (GO:0034587)2.32810518
193type I interferon signaling pathway (GO:0060337)2.32778239
194cellular response to type I interferon (GO:0071357)2.32778239
195maintenance of protein location in nucleus (GO:0051457)2.32752144
196positive regulation of natural killer cell activation (GO:0032816)2.32593797
197ovarian follicle development (GO:0001541)2.31036405
198positive regulation of defense response to virus by host (GO:0002230)2.30396888
199gonad development (GO:0008406)2.28839827
200gonadal mesoderm development (GO:0007506)17.8818741

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.99298708
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.57128998
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.75576240
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.72053868
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.42159585
6STAT6_21828071_ChIP-Seq_BEAS2B_Human3.41053024
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.31917232
8IGF1R_20145208_ChIP-Seq_DFB_Human3.29716754
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.27017171
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.22830573
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.22616214
12E2F4_17652178_ChIP-ChIP_JURKAT_Human3.17423330
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.15128186
14FOXM1_23109430_ChIP-Seq_U2OS_Human3.07199833
15IKZF1_21737484_ChIP-ChIP_HCT116_Human3.06263173
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.93932067
17AR_21909140_ChIP-Seq_LNCAP_Human2.92822900
18CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.88260822
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.83217578
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.81019318
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70597886
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.66153790
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.65360788
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.63651527
25MYC_18358816_ChIP-ChIP_MESCs_Mouse2.60649332
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.58112762
27POU5F1_16153702_ChIP-ChIP_HESCs_Human2.53990734
28CBX2_27304074_Chip-Seq_ESCs_Mouse2.53640866
29ETS1_20019798_ChIP-Seq_JURKAT_Human2.53180435
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.43496707
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.42514997
32E2F1_18555785_ChIP-Seq_MESCs_Mouse2.38469328
33NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35886907
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.29991964
35BP1_19119308_ChIP-ChIP_Hs578T_Human2.25081571
36ELK1_19687146_ChIP-ChIP_HELA_Human2.21762546
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.19249562
38TP63_19390658_ChIP-ChIP_HaCaT_Human2.18734697
39JARID2_20064375_ChIP-Seq_MESCs_Mouse2.18069509
40PCGF2_27294783_Chip-Seq_ESCs_Mouse2.08839148
41PCGF2_27294783_Chip-Seq_NPCs_Mouse2.06597116
42THAP11_20581084_ChIP-Seq_MESCs_Mouse2.01756106
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99714371
44POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.96398996
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.95735587
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94370454
47DCP1A_22483619_ChIP-Seq_HELA_Human1.92670709
48PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.91533033
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.91422738
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.88823321
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.87505753
52SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.86665489
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86010700
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84835175
55STAT4_19710469_ChIP-ChIP_TH1__Mouse1.79661728
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.77950279
57SCL_19346495_ChIP-Seq_HPC-7_Human1.77621963
58HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.76847060
59RNF2_27304074_Chip-Seq_ESCs_Mouse1.76100370
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.75685546
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.74404594
62RNF2_27304074_Chip-Seq_NSC_Mouse1.74250582
63VDR_23849224_ChIP-Seq_CD4+_Human1.74058293
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73766685
65GABP_19822575_ChIP-Seq_HepG2_Human1.72393998
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.71628386
67IRF8_27001747_Chip-Seq_BMDM_Mouse1.71059364
68MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70481099
69DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.70002567
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69158043
71FOXP3_21729870_ChIP-Seq_TREG_Human1.68168564
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.68159197
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.65628769
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.64704745
75SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.64593650
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.63649267
77EZH2_18974828_ChIP-Seq_MESCs_Mouse1.62886245
78RNF2_18974828_ChIP-Seq_MESCs_Mouse1.62886245
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.62776433
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.61169146
81KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.60326163
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.60296706
83E2F1_21310950_ChIP-Seq_MCF-7_Human1.60246310
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.59782251
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.59033811
86XRN2_22483619_ChIP-Seq_HELA_Human1.58266491
87NANOG_16153702_ChIP-ChIP_HESCs_Human1.56336056
88TTF2_22483619_ChIP-Seq_HELA_Human1.56053813
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.56043533
90MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.55633405
91EZH2_27294783_Chip-Seq_NPCs_Mouse1.54880270
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53845859
93PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.53842508
94EZH2_27304074_Chip-Seq_ESCs_Mouse1.52012080
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50545402
96POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49272521
97YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49132330
98ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47514535
99SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.45694066
100HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45378300
101ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45235166
102KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.39393298
103KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.39393298
104CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.38645750
105ZFX_18555785_Chip-Seq_ESCs_Mouse1.37923000
106STAT3_18555785_Chip-Seq_ESCs_Mouse1.37524103
107RUNX1_27457419_Chip-Seq_LIVER_Mouse1.37396493
108SOX17_20123909_ChIP-Seq_XEN_Mouse1.37285643
109JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37239396
110NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.36621029
111EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.36420241
112TCF3_18692474_ChIP-Seq_MEFs_Mouse1.35355281
113STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.33554810
114SUZ12_18555785_Chip-Seq_ESCs_Mouse1.33112416
115TP53_16413492_ChIP-PET_HCT116_Human1.32215503
116ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.31891476
117SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.31791382
118RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30950834
119YY1_21170310_ChIP-Seq_MESCs_Mouse1.29235628
120E2F1_18555785_Chip-Seq_ESCs_Mouse1.27932992
121NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.27832197
122SALL1_21062744_ChIP-ChIP_HESCs_Human1.26652484
123STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25767527
124POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25480251
125NMYC_18555785_Chip-Seq_ESCs_Mouse1.25236919
126SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25225418
127OCT4_18555785_Chip-Seq_ESCs_Mouse1.25171112
128GBX2_23144817_ChIP-Seq_PC3_Human1.23143372
129P300_18555785_Chip-Seq_ESCs_Mouse1.21588023
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18969627
131P53_22387025_ChIP-Seq_ESCs_Mouse1.18940155
132ELK1_22589737_ChIP-Seq_MCF10A_Human1.18767824
133PU1_27457419_Chip-Seq_LIVER_Mouse1.18454198
134CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.18297426
135VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18064447
136SOX2_18555785_Chip-Seq_ESCs_Mouse1.16721921
137NANOG_18555785_Chip-Seq_ESCs_Mouse1.15927511
138LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15614207
139CTCF_18555785_Chip-Seq_ESCs_Mouse1.15002777
140ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14682039
141SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13766153
142ESRRB_18555785_Chip-Seq_ESCs_Mouse1.12832894
143CMYC_18555785_Chip-Seq_ESCs_Mouse1.11944454
144SOX2_16153702_ChIP-ChIP_HESCs_Human1.11675439
145MYC_18940864_ChIP-ChIP_HL60_Human1.10220828
146KLF4_18555785_Chip-Seq_ESCs_Mouse1.09956552
147TAL1_26923725_Chip-Seq_HPCs_Mouse1.09683960
148ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.09210447
149CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09191052
150STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08823100
151TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08606337
152CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08233563
153STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.06618700
154E2F7_22180533_ChIP-Seq_HELA_Human1.06585210
155TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06515082
156PIAS1_25552417_ChIP-Seq_VCAP_Human1.05332037
157TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04131106
158POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04131106
159SMAD1_18555785_Chip-Seq_ESCs_Mouse1.03440715
160MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02718027
161OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01350355
162MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01250352
163KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00947417
164TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00375750
165POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00047016
166TP53_18474530_ChIP-ChIP_U2OS_Human0.99855003
167EZH2_27294783_Chip-Seq_ESCs_Mouse0.98688842
168ER_23166858_ChIP-Seq_MCF-7_Human0.98647045
169ESR1_21235772_ChIP-Seq_MCF-7_Human0.97823947
170CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97542357
171SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96729077
172TP63_17297297_ChIP-ChIP_HaCaT_Human0.96363277
173NOTCH1_21737748_ChIP-Seq_TLL_Human0.95496256
174SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94962938
175PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93203501
176E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92201351
177VDR_24787735_ChIP-Seq_THP-1_Human0.91661687
178FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.90850061
179KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90706174
180VDR_22108803_ChIP-Seq_LS180_Human0.90286227
181DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89327438
182EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89023101
183EOMES_21245162_ChIP-Seq_HESCs_Human0.88222486
184ELF5_23300383_ChIP-Seq_T47D_Human0.87784116
185TFEB_21752829_ChIP-Seq_HELA_Human0.87067728
186ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.86689662
187FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.83680641
188NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.83454272
189NANOG_18692474_ChIP-Seq_MEFs_Mouse0.82637202
190SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.81019750
191HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80615351
192NANOG_21062744_ChIP-ChIP_HESCs_Human0.80006432
193CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.77972753
194OCT4_18692474_ChIP-Seq_MEFs_Mouse0.77503433
195KDM5A_27292631_Chip-Seq_BREAST_Human0.76857885
196SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.76387138

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence6.27677411
2MP0003693_abnormal_embryo_hatching4.53451335
3MP0004957_abnormal_blastocyst_morpholog3.90234439
4MP0003806_abnormal_nucleotide_metabolis3.47800742
5MP0005377_hearing/vestibular/ear_phenot3.45354478
6MP0003878_abnormal_ear_physiology3.45354478
7MP0010094_abnormal_chromosome_stability3.26669674
8MP0009379_abnormal_foot_pigmentation3.15976826
9MP0008058_abnormal_DNA_repair3.12138718
10MP0005171_absent_coat_pigmentation3.00190022
11MP0003111_abnormal_nucleus_morphology2.99059720
12MP0008932_abnormal_embryonic_tissue2.87821906
13MP0003123_paternal_imprinting2.86778567
14MP0003718_maternal_effect2.76483036
15MP0003077_abnormal_cell_cycle2.73333963
16MP0008007_abnormal_cellular_replicative2.65876518
17MP0004147_increased_porphyrin_level2.63729360
18MP0009697_abnormal_copulation2.58907079
19MP0009384_cardiac_valve_regurgitation2.57375524
20MP0010352_gastrointestinal_tract_polyps2.54310944
21MP0005647_abnormal_sex_gland2.53006710
22MP0003315_abnormal_perineum_morphology2.32023303
23MP0001835_abnormal_antigen_presentation2.27099544
24MP0005671_abnormal_response_to2.17669454
25MP0009278_abnormal_bone_marrow2.13789175
26MP0001873_stomach_inflammation2.10471150
27MP0000685_abnormal_immune_system2.04315820
28MP0010030_abnormal_orbit_morphology2.01309570
29MP0002102_abnormal_ear_morphology2.01188389
30MP0003136_yellow_coat_color2.00826231
31MP0002148_abnormal_hypersensitivity_rea1.98400394
32MP0000566_synostosis1.97872857
33MP0001188_hyperpigmentation1.96958638
34MP0003786_premature_aging1.92014814
35MP0001730_embryonic_growth_arrest1.81541054
36MP0009672_abnormal_birth_weight1.79203909
37MP0003890_abnormal_embryonic-extraembry1.76986589
38MP0002009_preneoplasia1.73423055
39MP0005389_reproductive_system_phenotype1.72529741
40MP0001666_abnormal_nutrient_absorption1.71333161
41MP0001293_anophthalmia1.69728505
42MP0002163_abnormal_gland_morphology1.67520389
43MP0003950_abnormal_plasma_membrane1.63532619
44MP0002160_abnormal_reproductive_system1.60972641
45MP0001958_emphysema1.60495707
46MP0000350_abnormal_cell_proliferation1.60415324
47MP0002210_abnormal_sex_determination1.56387840
48MP0003195_calcinosis1.56284516
49MP0003119_abnormal_digestive_system1.54688194
50MP0001346_abnormal_lacrimal_gland1.49714859
51MP0003566_abnormal_cell_adhesion1.49381671
52MP0003941_abnormal_skin_development1.49054124
53MP0002796_impaired_skin_barrier1.47730379
54MP0001919_abnormal_reproductive_system1.46584469
55MP0008877_abnormal_DNA_methylation1.43106629
56MP0005379_endocrine/exocrine_gland_phen1.42467414
57MP0001853_heart_inflammation1.41594635
58MP0005257_abnormal_intraocular_pressure1.41476876
59MP0003937_abnormal_limbs/digits/tail_de1.40015023
60MP0003186_abnormal_redox_activity1.39429809
61MP0001790_abnormal_immune_system1.37364456
62MP0005387_immune_system_phenotype1.37364456
63MP0000613_abnormal_salivary_gland1.35954643
64MP0002132_abnormal_respiratory_system1.34026899
65MP0001485_abnormal_pinna_reflex1.33193789
66MP0003763_abnormal_thymus_physiology1.31947930
67MP0001697_abnormal_embryo_size1.31436830
68MP0002085_abnormal_embryonic_tissue1.30005515
69MP0002084_abnormal_developmental_patter1.29061641
70MP0005380_embryogenesis_phenotype1.28615270
71MP0001672_abnormal_embryogenesis/_devel1.28615270
72MP0005174_abnormal_tail_pigmentation1.28424450
73MP0005310_abnormal_salivary_gland1.28414230
74MP0006036_abnormal_mitochondrial_physio1.28005136
75MP0006292_abnormal_olfactory_placode1.26792598
76MP0002938_white_spotting1.26060710
77MP0008789_abnormal_olfactory_epithelium1.25809057
78MP0005645_abnormal_hypothalamus_physiol1.25349847
79MP0000631_abnormal_neuroendocrine_gland1.25050781
80MP0002080_prenatal_lethality1.23730137
81MP0000470_abnormal_stomach_morphology1.23387723
82MP0004272_abnormal_basement_membrane1.22697567
83MP0000372_irregular_coat_pigmentation1.22012631
84MP0006035_abnormal_mitochondrial_morpho1.21356065
85MP0002452_abnormal_antigen_presenting1.21083345
86MP0003567_abnormal_fetal_cardiomyocyte1.21075664
87MP0000015_abnormal_ear_pigmentation1.20193052
88MP0001661_extended_life_span1.19496982
89MP0003045_fibrosis1.19468551
90MP0001119_abnormal_female_reproductive1.18875256
91MP0001145_abnormal_male_reproductive1.17984740
92MP0003936_abnormal_reproductive_system1.17155007
93MP0000762_abnormal_tongue_morphology1.14364904
94MP0001800_abnormal_humoral_immune1.13848657
95MP0004019_abnormal_vitamin_homeostasis1.13592693
96MP0009785_altered_susceptibility_to1.13066608
97MP0002233_abnormal_nose_morphology1.12248791
98MP0000537_abnormal_urethra_morphology1.10615686
99MP0010234_abnormal_vibrissa_follicle1.10179785
100MP0001819_abnormal_immune_cell1.09650440
101MP0000569_abnormal_digit_pigmentation1.09554896
102MP0005365_abnormal_bile_salt1.09173489
103MP0002420_abnormal_adaptive_immunity1.08832676
104MP0005000_abnormal_immune_tolerance1.08762364
105MP0003121_genomic_imprinting1.07509349
106MP0002419_abnormal_innate_immunity1.06927274
107MP0003984_embryonic_growth_retardation1.06708777
108MP0005670_abnormal_white_adipose1.05896229
109MP0002088_abnormal_embryonic_growth/wei1.05140972
110MP0000681_abnormal_thyroid_gland1.04882838
111MP0008057_abnormal_DNA_replication1.04775073
112MP0005025_abnormal_response_to1.04474762
113MP0004742_abnormal_vestibular_system1.04426014
114MP0002111_abnormal_tail_morphology1.04180808
115MP0005408_hypopigmentation1.03842586
116MP0000579_abnormal_nail_morphology1.03292487
117MP0005395_other_phenotype1.02108417
118MP0009333_abnormal_splenocyte_physiolog1.00951332
119MP0009780_abnormal_chondrocyte_physiolo1.00918518
120MP0000383_abnormal_hair_follicle1.00544981
121MP0002254_reproductive_system_inflammat0.99428177
122MP0001929_abnormal_gametogenesis0.99139611
123MP0005501_abnormal_skin_physiology0.98540932
124MP0005409_darkened_coat_color0.98247132
125MP0008875_abnormal_xenobiotic_pharmacok0.97826467
126MP0005360_urolithiasis0.96231515
127MP0002697_abnormal_eye_size0.95986129
128MP0000653_abnormal_sex_gland0.95878316
129MP0001881_abnormal_mammary_gland0.95562647
130MP0004197_abnormal_fetal_growth/weight/0.94979980
131MP0005367_renal/urinary_system_phenotyp0.94841273
132MP0000516_abnormal_urinary_system0.94841273
133MP0005332_abnormal_amino_acid0.94808692
134MP0000639_abnormal_adrenal_gland0.94394779
135MP0002723_abnormal_immune_serum0.89485836
136MP0002086_abnormal_extraembryonic_tissu0.88568608
137MP0004264_abnormal_extraembryonic_tissu0.88538062
138MP0001286_abnormal_eye_development0.88155543
139MP0001529_abnormal_vocalization0.87881969
140MP0001664_abnormal_digestion0.87768046
141MP0003866_abnormal_defecation0.87232183
142MP0009703_decreased_birth_body0.86718254
143MP0010155_abnormal_intestine_physiology0.86389224
144MP0000358_abnormal_cell_content/0.85374557
145MP0001663_abnormal_digestive_system0.85216276
146MP0000313_abnormal_cell_death0.85183157
147MP0003879_abnormal_hair_cell0.84837087
148MP0005499_abnormal_olfactory_system0.83617776
149MP0005394_taste/olfaction_phenotype0.83617776
150MP0002095_abnormal_skin_pigmentation0.83545586
151MP0000049_abnormal_middle_ear0.82135686
152MP0001299_abnormal_eye_distance/0.81616854
153MP0001545_abnormal_hematopoietic_system0.80464795
154MP0005397_hematopoietic_system_phenotyp0.80464795
155MP0005248_abnormal_Harderian_gland0.79368099
156MP0005085_abnormal_gallbladder_physiolo0.79136960
157MP0002396_abnormal_hematopoietic_system0.78220735
158MP0002060_abnormal_skin_morphology0.77655702
159MP0003828_pulmonary_edema0.77155224
160MP0005381_digestive/alimentary_phenotyp0.76221386
161MP0005503_abnormal_tendon_morphology0.75986588
162MP0000490_abnormal_crypts_of0.75705850
163MP0002876_abnormal_thyroid_physiology0.75555915
164MP0001849_ear_inflammation0.75329223
165MP0002405_respiratory_system_inflammati0.74644730
166MP0010307_abnormal_tumor_latency0.74265462
167MP0002277_abnormal_respiratory_mucosa0.73942743
168MP0001764_abnormal_homeostasis0.73351841
169MP0003698_abnormal_male_reproductive0.72177764
170MP0000647_abnormal_sebaceous_gland0.71435695
171MP0002098_abnormal_vibrissa_morphology0.71285422
172MP0003724_increased_susceptibility_to0.71039441
173MP0003300_gastrointestinal_ulcer0.70091638
174MP0004133_heterotaxia0.69379218
175MP0005330_cardiomyopathy0.68932035
176MP0002090_abnormal_vision0.67569256
177MP0002398_abnormal_bone_marrow0.67139167
178MP0002168_other_aberrant_phenotype0.66977929
179MP0000627_abnormal_mammary_gland0.66571990
180MP0003122_maternal_imprinting0.66317819
181MP0000751_myopathy0.66197666
182MP0003868_abnormal_feces_composition0.62806067
183MP0005384_cellular_phenotype0.61959891

Predicted human phenotypes

RankGene SetZ-score
1Gonadal dysgenesis (HP:0000133)8.82996338
2Abnormal sex determination (HP:0012244)6.93027550
3Sex reversal (HP:0012245)6.93027550
4Male pseudohermaphroditism (HP:0000037)6.43938541
5Gonadotropin excess (HP:0000837)5.85256619
6Testicular neoplasm (HP:0010788)5.16032114
7Male infertility (HP:0003251)4.93241061
8Abnormality of male internal genitalia (HP:0000022)4.37927038
9Azoospermia (HP:0000027)4.10068055
10Hypoplastic left heart (HP:0004383)4.09800694
11Hypoplasia of the uterus (HP:0000013)3.85237670
12Aplasia/hypoplasia of the uterus (HP:0008684)3.60729107
13Reduced antithrombin III activity (HP:0001976)3.35028955
14Abnormality of the labia minora (HP:0012880)3.34703748
15Increased hepatocellular lipid droplets (HP:0006565)3.34452688
16Increased serum pyruvate (HP:0003542)3.32478052
17Abnormality of methionine metabolism (HP:0010901)3.31093014
18Abnormal spermatogenesis (HP:0008669)3.23240939
19Hypoplastic heart (HP:0001961)3.12763007
20Abnormality of glycolysis (HP:0004366)3.11547587
21Acute encephalopathy (HP:0006846)3.10770933
22Germ cell neoplasia (HP:0100728)3.10441719
23Hypoglycemic seizures (HP:0002173)3.08461367
24Acute necrotizing encephalopathy (HP:0006965)3.07873882
25Abnormality of serum amino acid levels (HP:0003112)2.98994968
26Lipid accumulation in hepatocytes (HP:0006561)2.98881166
27Type I transferrin isoform profile (HP:0003642)2.94833596
28Abnormality of aspartate family amino acid metabolism (HP:0010899)2.84483941
29Onycholysis (HP:0001806)2.82372397
30Methylmalonic acidemia (HP:0002912)2.81612502
31Colon cancer (HP:0003003)2.80895281
32Pulmonary fibrosis (HP:0002206)2.76590738
33Abnormal mitochondria in muscle tissue (HP:0008316)2.73925915
34Hyperglycinemia (HP:0002154)2.68857072
35Methylmalonic aciduria (HP:0012120)2.68465915
36Follicular hyperkeratosis (HP:0007502)2.66712866
37Symptomatic seizures (HP:0011145)2.66099938
38Mitochondrial inheritance (HP:0001427)2.63312113
39Aplasia/Hypoplasia of the spleen (HP:0010451)2.63168864
40Chromosomal breakage induced by crosslinking agents (HP:0003221)2.63035060
41Hypoglycemic coma (HP:0001325)2.62811749
42Hyperinsulinemic hypoglycemia (HP:0000825)2.61108616
43Increased CSF lactate (HP:0002490)2.60836011
44Rough bone trabeculation (HP:0100670)2.56373093
45Progressive macrocephaly (HP:0004481)2.54567898
46Pulmonary artery stenosis (HP:0004415)2.52575334
47Abnormal protein glycosylation (HP:0012346)2.52022173
48Abnormal glycosylation (HP:0012345)2.52022173
49Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.52022173
50Abnormal protein N-linked glycosylation (HP:0012347)2.52022173
51Sparse eyelashes (HP:0000653)2.51110550
52Spastic diplegia (HP:0001264)2.45295682
53Multiple enchondromatosis (HP:0005701)2.43604184
54Hepatocellular necrosis (HP:0001404)2.42251561
55Dry hair (HP:0011359)2.41243167
56Cerebral edema (HP:0002181)2.39796589
57Birth length less than 3rd percentile (HP:0003561)2.39079735
58Asplenia (HP:0001746)2.38647739
59Chromsome breakage (HP:0040012)2.38529447
60Agammaglobulinemia (HP:0004432)2.37943153
61Aplasia/Hypoplasia of the sacrum (HP:0008517)2.35859122
62Ankle contracture (HP:0006466)2.34557079
63Intrahepatic cholestasis (HP:0001406)2.33804829
64Prominent metopic ridge (HP:0005487)2.31382479
65Abnormality of the preputium (HP:0100587)2.31326436
66Renal Fanconi syndrome (HP:0001994)2.30689807
67Anomalous pulmonary venous return (HP:0010772)2.29169037
68Abnormality of the axillary hair (HP:0100134)2.28556543
69Abnormality of secondary sexual hair (HP:0009888)2.28556543
70Megaloblastic anemia (HP:0001889)2.26589802
71Elevated erythrocyte sedimentation rate (HP:0003565)2.25573142
72Infertility (HP:0000789)2.24495350
73Microglossia (HP:0000171)2.24338302
74Meckel diverticulum (HP:0002245)2.23271264
7511 pairs of ribs (HP:0000878)2.22403825
76Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.22121331
77Decreased activity of mitochondrial respiratory chain (HP:0008972)2.22121331
78Aplasia cutis congenita (HP:0001057)2.21958860
79Selective tooth agenesis (HP:0001592)2.21576311
80Pancreatic islet-cell hyperplasia (HP:0004510)2.20124153
81Reticulocytopenia (HP:0001896)2.18806508
82Hepatic necrosis (HP:0002605)2.18507755
83Hypoplastic female external genitalia (HP:0012815)2.17962206
84Abnormality of glycine metabolism (HP:0010895)2.17833142
85Abnormality of serine family amino acid metabolism (HP:0010894)2.17833142
86Postnatal microcephaly (HP:0005484)2.17479014
87Hypobetalipoproteinemia (HP:0003563)2.17434217
88Facial cleft (HP:0002006)2.16721940
89Gastrointestinal infarctions (HP:0005244)2.16316789
90True hermaphroditism (HP:0010459)2.14957987
91Recurrent lower respiratory tract infections (HP:0002783)2.14042883
92Abnormality of the pulmonary veins (HP:0011718)2.12995388
93Neoplasm of the adrenal gland (HP:0100631)2.12207779
94Mediastinal lymphadenopathy (HP:0100721)2.12186525
95Increased serum lactate (HP:0002151)2.11572668
96Short middle phalanx of the 5th finger (HP:0004220)2.11289951
97Prolonged partial thromboplastin time (HP:0003645)2.11051390
98Abnormality of chromosome stability (HP:0003220)2.10698163
99Abnormal trabecular bone morphology (HP:0100671)2.09579295
100Stenosis of the external auditory canal (HP:0000402)2.09296410
101Transposition of the great arteries (HP:0001669)2.07762021
102Abnormal connection of the cardiac segments (HP:0011545)2.07762021
103Abnormal ventriculo-arterial connection (HP:0011563)2.07762021
104Chronic bronchitis (HP:0004469)2.06343008
105Right ventricular cardiomyopathy (HP:0011663)2.05878086
106Abnormality of the vitamin B12 metabolism (HP:0004341)2.05544378
107Nausea (HP:0002018)2.05422229
108Median cleft lip (HP:0000161)2.05389302
109Hyperpituitarism (HP:0010514)2.05166338
110Abnormality of the ileum (HP:0001549)2.03222566
111Rectal prolapse (HP:0002035)2.02904466
112Oral leukoplakia (HP:0002745)2.02114227
113Secondary amenorrhea (HP:0000869)2.01644235
114Mesangial abnormality (HP:0001966)2.00553902
115Nephroblastoma (Wilms tumor) (HP:0002667)1.98974933
116Palpitations (HP:0001962)1.98436081
117Recurrent pneumonia (HP:0006532)1.97122945
118Abnormality of vitamin B metabolism (HP:0004340)1.95705796
119Ependymoma (HP:0002888)1.94818115
120Retrobulbar optic neuritis (HP:0100654)1.94468903
121Optic neuritis (HP:0100653)1.94468903
122Vascular calcification (HP:0004934)1.94039461
123Duplicated collecting system (HP:0000081)1.94013246
124Female pseudohermaphroditism (HP:0010458)1.93340675
125Ectopic kidney (HP:0000086)1.92526793
126Exercise intolerance (HP:0003546)1.91192305
127Adrenal hypoplasia (HP:0000835)1.91127727
128Abnormality of sulfur amino acid metabolism (HP:0004339)1.90978490
129Lethargy (HP:0001254)1.90212798
130Primary adrenal insufficiency (HP:0008207)1.89484180
131Exertional dyspnea (HP:0002875)1.89071420
132Lactic acidosis (HP:0003128)1.88706741
133Fragile skin (HP:0001030)1.87637477
134Gastrointestinal stroma tumor (HP:0100723)1.86490408
135Conical tooth (HP:0000698)1.86321064
136Hypoplastic pelvis (HP:0008839)1.85899713
137Small intestinal stenosis (HP:0012848)1.85626887
138Duodenal stenosis (HP:0100867)1.85626887
139Primary amenorrhea (HP:0000786)1.84668470
140Shoulder girdle muscle weakness (HP:0003547)1.84118855
141Increased intramyocellular lipid droplets (HP:0012240)1.83224131
142Cerebral hypomyelination (HP:0006808)1.82841774
143Abnormality of the labia (HP:0000058)1.81721031
144Abnormality of the metopic suture (HP:0005556)1.80888691
145Recurrent sinusitis (HP:0011108)1.80560841
146Biliary tract neoplasm (HP:0100574)1.77583874
147Embryonal renal neoplasm (HP:0011794)1.77057054
148Prostate neoplasm (HP:0100787)1.76933338
149Gout (HP:0001997)1.76927673
150Abnormality of incisor morphology (HP:0011063)1.76747587
151Abnormality of aromatic amino acid family metabolism (HP:0004338)1.76363527
152Labial hypoplasia (HP:0000066)1.75714555
153Abnormality of endocrine pancreas physiology (HP:0012093)1.75623569
154Abnormality of the pancreatic islet cells (HP:0006476)1.75623569
155Abnormality of the renal collecting system (HP:0004742)1.75454024
156Rhabdomyosarcoma (HP:0002859)1.74416470
157Hyperglycinuria (HP:0003108)1.74127451
158Orchitis (HP:0100796)1.72298706
159Abnormal lung lobation (HP:0002101)1.71821534
160Premature ovarian failure (HP:0008209)1.71382132
161Abnormal number of erythroid precursors (HP:0012131)1.71374342
162Recurrent abscess formation (HP:0002722)1.70153982
163Stage 5 chronic kidney disease (HP:0003774)1.69164750
164Myositis (HP:0100614)1.68884115
165Chronic mucocutaneous candidiasis (HP:0002728)1.67354047
166Recurrent cutaneous fungal infections (HP:0011370)1.67354047
167Meningitis (HP:0001287)1.67057680
168Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.65302900
169Midline defect of the nose (HP:0004122)1.63315130
170Tongue fasciculations (HP:0001308)1.62369695
171IgM deficiency (HP:0002850)1.61699612
172Basal ganglia calcification (HP:0002135)1.60578408
173Porencephaly (HP:0002132)1.58201849
174Recurrent bronchitis (HP:0002837)1.57414120
175Abnormality of molar (HP:0011077)1.56606939
176Abnormality of molar morphology (HP:0011070)1.56606939
177Bifid tongue (HP:0010297)1.56152398
178Craniofacial hyperostosis (HP:0004493)1.55018596
179Abnormality of cells of the erythroid lineage (HP:0012130)1.54826726
180Nasolacrimal duct obstruction (HP:0000579)1.54447345
181Hypergonadotropic hypogonadism (HP:0000815)1.54256875
182Premature loss of primary teeth (HP:0006323)1.53220739
183Aortic valve stenosis (HP:0001650)1.52360559
184Duplication of thumb phalanx (HP:0009942)1.51496714
185Stomach cancer (HP:0012126)1.50864145
186Abnormal delayed hypersensitivity skin test (HP:0002963)1.50677278
187Petechiae (HP:0000967)1.50496023
188Abnormality of the phalanges of the 5th finger (HP:0004213)1.50466644
189Dynein arm defect of respiratory motile cilia (HP:0012255)1.50315055
190Absent/shortened dynein arms (HP:0200106)1.50315055
191Abnormality of the parietal bone (HP:0002696)1.50207428

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.02559554
2VRK23.79398600
3TSSK63.62067005
4MST43.45335045
5IRAK33.19377462
6TTK2.98571125
7IRAK42.96680812
8MST1R2.86518949
9MAP3K142.80642817
10CASK2.67315621
11NEK12.63774112
12TNK22.63734532
13CDC72.62780465
14MUSK2.55358282
15ACVR1B2.50775689
16CDK72.47798844
17PBK2.47046225
18PLK32.43372350
19EPHA22.34344948
20MKNK12.31487274
21GRK12.28380934
22MKNK22.13908135
23TRIM282.10899491
24EIF2AK12.02314871
25NME11.94169592
26JAK31.88104533
27TNIK1.87157878
28EIF2AK31.82642200
29BLK1.78497786
30TAF11.75168254
31WNK31.73923407
32IKBKE1.66362013
33NLK1.63995898
34BMPR1B1.60386537
35CHUK1.60159393
36PLK11.59691562
37STK161.59399957
38MAP4K11.56093008
39LMTK21.55949473
40BTK1.55317813
41MAP3K121.51404718
42BRSK21.49659399
43PAK41.49535557
44IKBKB1.48244247
45PLK41.46704419
46CLK11.44650697
47CDK41.43093111
48STK38L1.42843083
49TESK11.40297174
50EPHB11.38697956
51LIMK11.38076005
52BMPR21.34131230
53ERBB41.33854700
54STK41.33461196
55YES11.33424533
56CDK91.32874602
57TYRO31.32797784
58STK391.31200743
59MET1.30706386
60STK241.28728659
61TESK21.24775305
62PTK61.23645304
63CDK81.22863089
64PIK3CG1.17390213
65WNK41.16351785
66MAP2K21.13961546
67WEE11.12746476
68TXK1.12389186
69BRSK11.11479847
70MATK1.10018723
71MYLK1.09605511
72KIT1.06381958
73EPHB21.05687592
74NME21.03187002
75CDK190.99092358
76CDK30.98360620
77STK100.96576570
78CDK120.95974313
79TYK20.95371796
80TBK10.94010875
81STK30.93964929
82BRD40.93625459
83TEC0.92961546
84AURKB0.92932986
85BCR0.92462243
86ADRBK20.89842603
87PDK20.89094414
88DYRK30.86607279
89IRAK10.86356493
90LATS10.85039744
91DAPK10.84824942
92TLK10.81837856
93PASK0.79446395
94EPHA30.78444286
95FGFR10.78186214
96EIF2AK20.77724662
97GRK70.74672933
98ALK0.74024705
99TRIB30.74003835
100BCKDK0.72631882
101MAP3K130.71952301
102NEK60.67904781
103NUAK10.67332542
104CSNK1A1L0.66010383
105LYN0.64178200
106MAPK30.63611667
107WNK10.63515687
108CHEK20.63251700
109NEK20.62749441
110SYK0.61381135
111OXSR10.61275309
112AURKA0.61066297
113PRKCQ0.60999778
114SRPK10.60879619
115DYRK20.60698125
116SIK30.60391493
117VRK10.57466517
118PIM10.56979290
119PAK10.56088179
120ZAK0.56000591
121CDC42BPA0.55636854
122MAPKAPK50.55374140
123ABL20.54852627
124CSNK1G30.54733501
125ERBB30.54111751
126CSNK1G10.54003275
127MAP3K80.53685193
128PTK20.52754332
129BRAF0.52454800
130ERBB20.48170955
131PRKCE0.48068701
132RPS6KA40.46777245
133CSNK2A10.46578372
134CSNK2A20.46328778
135RPS6KA50.46102491
136ABL10.45483601
137TRPM70.45361856
138MELK0.44712932
139ATM0.44382916
140LATS20.42676868
141CSNK1G20.42606409
142PLK20.42189701
143MAP2K70.41984033
144CHEK10.41088060
145MAPKAPK20.40408102
146CSNK1A10.40381088
147PRKCI0.40131448
148MAPK130.39023910
149ATR0.38660130
150HCK0.38450718
151CSK0.38077526
152LCK0.34980775
153BMX0.34951773
154FES0.34619550
155NEK90.33351890
156CSNK1E0.32858247
157TIE10.32825782
158AKT10.32105208
159KDR0.29622169
160MAP3K50.28899204
161ARAF0.28143682
162FLT30.26682021
163CDK10.24184795
164SMG10.23868741
165MAP3K20.22449028
166CCNB10.21252490
167TGFBR10.19171246
168MINK10.18726333

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.18987937
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.82315403
3Ovarian steroidogenesis_Homo sapiens_hsa049132.71575705
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.47660040
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.37085557
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.18143124
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.11260822
8Vitamin B6 metabolism_Homo sapiens_hsa007502.06980031
9Steroid hormone biosynthesis_Homo sapiens_hsa001402.05523552
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.99796424
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.92691933
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.91449992
13Cysteine and methionine metabolism_Homo sapiens_hsa002701.86212088
14Pyruvate metabolism_Homo sapiens_hsa006201.82595271
15Allograft rejection_Homo sapiens_hsa053301.76518129
16Autoimmune thyroid disease_Homo sapiens_hsa053201.75345423
17Oxidative phosphorylation_Homo sapiens_hsa001901.75200099
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.73296135
19Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.71445315
20RNA transport_Homo sapiens_hsa030131.71334747
21Steroid biosynthesis_Homo sapiens_hsa001001.69968862
22Ribosome_Homo sapiens_hsa030101.66992471
23Propanoate metabolism_Homo sapiens_hsa006401.63564707
24Biosynthesis of amino acids_Homo sapiens_hsa012301.63004990
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.62842442
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.62090231
27ECM-receptor interaction_Homo sapiens_hsa045121.62076063
28One carbon pool by folate_Homo sapiens_hsa006701.61789263
29Parkinsons disease_Homo sapiens_hsa050121.59569153
30Protein digestion and absorption_Homo sapiens_hsa049741.56025540
31Arachidonic acid metabolism_Homo sapiens_hsa005901.55499937
32Nucleotide excision repair_Homo sapiens_hsa034201.54455859
33Graft-versus-host disease_Homo sapiens_hsa053321.53923275
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.53799725
35Fatty acid biosynthesis_Homo sapiens_hsa000611.52947681
36Primary immunodeficiency_Homo sapiens_hsa053401.51421693
37Protein export_Homo sapiens_hsa030601.48462778
38Hedgehog signaling pathway_Homo sapiens_hsa043401.43887342
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.43845032
40Toll-like receptor signaling pathway_Homo sapiens_hsa046201.43012540
41Measles_Homo sapiens_hsa051621.42343060
42Herpes simplex infection_Homo sapiens_hsa051681.41745402
43Carbon metabolism_Homo sapiens_hsa012001.40888617
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39802489
45Leishmaniasis_Homo sapiens_hsa051401.37458000
46Huntingtons disease_Homo sapiens_hsa050161.36646581
47Cell cycle_Homo sapiens_hsa041101.33564252
48Folate biosynthesis_Homo sapiens_hsa007901.33215586
49Toxoplasmosis_Homo sapiens_hsa051451.32623724
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30464360
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.24774021
52Asthma_Homo sapiens_hsa053101.24671987
53Vitamin digestion and absorption_Homo sapiens_hsa049771.24265629
54Homologous recombination_Homo sapiens_hsa034401.23735933
55Fanconi anemia pathway_Homo sapiens_hsa034601.23531870
56Small cell lung cancer_Homo sapiens_hsa052221.23274393
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.23167292
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22161571
59Non-homologous end-joining_Homo sapiens_hsa034501.22005277
60Fatty acid elongation_Homo sapiens_hsa000621.21948109
61NOD-like receptor signaling pathway_Homo sapiens_hsa046211.20539784
62Pentose and glucuronate interconversions_Homo sapiens_hsa000401.19875067
63Influenza A_Homo sapiens_hsa051641.17399990
64Ether lipid metabolism_Homo sapiens_hsa005651.16676680
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15941614
66DNA replication_Homo sapiens_hsa030301.15310026
67Hematopoietic cell lineage_Homo sapiens_hsa046401.13654291
68Galactose metabolism_Homo sapiens_hsa000521.12138736
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10661455
70Linoleic acid metabolism_Homo sapiens_hsa005911.08500491
71Selenocompound metabolism_Homo sapiens_hsa004501.07198339
72Basal cell carcinoma_Homo sapiens_hsa052171.03059588
73Antigen processing and presentation_Homo sapiens_hsa046121.02550196
74TGF-beta signaling pathway_Homo sapiens_hsa043501.02405203
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01203537
76Alzheimers disease_Homo sapiens_hsa050100.99489270
77Caffeine metabolism_Homo sapiens_hsa002320.98133624
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97214905
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97064398
80Prolactin signaling pathway_Homo sapiens_hsa049170.96156211
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95852606
82Sulfur metabolism_Homo sapiens_hsa009200.95029978
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94543234
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93503514
85Mismatch repair_Homo sapiens_hsa034300.92444109
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91867841
87RNA polymerase_Homo sapiens_hsa030200.90850949
88Notch signaling pathway_Homo sapiens_hsa043300.88905504
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88235313
90Fat digestion and absorption_Homo sapiens_hsa049750.88219295
91B cell receptor signaling pathway_Homo sapiens_hsa046620.88170743
92Basal transcription factors_Homo sapiens_hsa030220.87812395
93Sphingolipid metabolism_Homo sapiens_hsa006000.86954776
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.86534995
95Pertussis_Homo sapiens_hsa051330.86344434
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.86131551
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85379106
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84755460
99Base excision repair_Homo sapiens_hsa034100.83617494
100Mineral absorption_Homo sapiens_hsa049780.82737840
101Legionellosis_Homo sapiens_hsa051340.82292344
102Malaria_Homo sapiens_hsa051440.81377134
103Pancreatic secretion_Homo sapiens_hsa049720.81313644
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78677741
105Metabolic pathways_Homo sapiens_hsa011000.77687187
106Arginine and proline metabolism_Homo sapiens_hsa003300.77372362
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77230380
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76400471
109Fatty acid degradation_Homo sapiens_hsa000710.74888701
110TNF signaling pathway_Homo sapiens_hsa046680.73100330
111Osteoclast differentiation_Homo sapiens_hsa043800.72485847
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72351306
113N-Glycan biosynthesis_Homo sapiens_hsa005100.71436958
114Retinol metabolism_Homo sapiens_hsa008300.70697836
115Chemokine signaling pathway_Homo sapiens_hsa040620.70647020
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70463678
117Peroxisome_Homo sapiens_hsa041460.70323490
118Starch and sucrose metabolism_Homo sapiens_hsa005000.69635715
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69366912
120Glutathione metabolism_Homo sapiens_hsa004800.69239981
121Sulfur relay system_Homo sapiens_hsa041220.68534866
122Arginine biosynthesis_Homo sapiens_hsa002200.68020117
123Histidine metabolism_Homo sapiens_hsa003400.67515669
124beta-Alanine metabolism_Homo sapiens_hsa004100.67461636
125African trypanosomiasis_Homo sapiens_hsa051430.66438268
126Primary bile acid biosynthesis_Homo sapiens_hsa001200.66334543
127Apoptosis_Homo sapiens_hsa042100.65237898
128Pentose phosphate pathway_Homo sapiens_hsa000300.64881278
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64332715
130Viral myocarditis_Homo sapiens_hsa054160.63822380
131Hepatitis B_Homo sapiens_hsa051610.63388093
132p53 signaling pathway_Homo sapiens_hsa041150.62753255
133Prostate cancer_Homo sapiens_hsa052150.61685525
134Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61344414
135Cyanoamino acid metabolism_Homo sapiens_hsa004600.61311027
136Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60992173
137Fructose and mannose metabolism_Homo sapiens_hsa000510.60232738
138Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60012554
139mRNA surveillance pathway_Homo sapiens_hsa030150.59897545
140Pathways in cancer_Homo sapiens_hsa052000.56770299
141Chemical carcinogenesis_Homo sapiens_hsa052040.56595598
142Amoebiasis_Homo sapiens_hsa051460.55634742
143Fatty acid metabolism_Homo sapiens_hsa012120.55343426
144Tuberculosis_Homo sapiens_hsa051520.55219069
145Hepatitis C_Homo sapiens_hsa051600.55108084
146Oocyte meiosis_Homo sapiens_hsa041140.54495886
147RNA degradation_Homo sapiens_hsa030180.53847072
148Salmonella infection_Homo sapiens_hsa051320.53616254
149Type I diabetes mellitus_Homo sapiens_hsa049400.53223167
150Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53164816
151HTLV-I infection_Homo sapiens_hsa051660.53005121
152Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52449123
153Pyrimidine metabolism_Homo sapiens_hsa002400.52398135
154Phenylalanine metabolism_Homo sapiens_hsa003600.52023100
155Tryptophan metabolism_Homo sapiens_hsa003800.51903206
156Butanoate metabolism_Homo sapiens_hsa006500.51109100
157Tyrosine metabolism_Homo sapiens_hsa003500.49699725
158Spliceosome_Homo sapiens_hsa030400.48407862
159Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48344677
160Other glycan degradation_Homo sapiens_hsa005110.47725330
161Leukocyte transendothelial migration_Homo sapiens_hsa046700.46766874
162Platelet activation_Homo sapiens_hsa046110.46081134
163Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45798002
164Axon guidance_Homo sapiens_hsa043600.45552947
165Pancreatic cancer_Homo sapiens_hsa052120.43082322
166Focal adhesion_Homo sapiens_hsa045100.41719454
167Tight junction_Homo sapiens_hsa045300.40987155
168Purine metabolism_Homo sapiens_hsa002300.40473417
169Hippo signaling pathway_Homo sapiens_hsa043900.37553837
170Adherens junction_Homo sapiens_hsa045200.36602430
171Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33841440
172Maturity onset diabetes of the young_Homo sapiens_hsa049500.32311308
173Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30115038
174Thyroid cancer_Homo sapiens_hsa052160.26760980

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