KCTD15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1planar cell polarity pathway involved in neural tube closure (GO:0090179)5.67450737
2regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)5.30419088
3desmosome organization (GO:0002934)5.29253021
4paraxial mesoderm development (GO:0048339)4.50389322
5lateral sprouting from an epithelium (GO:0060601)4.35068517
6G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.24923054
7hemidesmosome assembly (GO:0031581)4.18713781
8outer ear morphogenesis (GO:0042473)4.07202346
9cochlea morphogenesis (GO:0090103)3.87912537
10non-canonical Wnt signaling pathway (GO:0035567)3.77481936
11polarized epithelial cell differentiation (GO:0030859)3.65274416
12proximal/distal pattern formation (GO:0009954)3.63649356
13establishment of skin barrier (GO:0061436)3.59308317
14positive regulation of gastrulation (GO:2000543)3.59167908
15Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.55620305
16regulation of water loss via skin (GO:0033561)3.54885897
17negative regulation of catenin import into nucleus (GO:0035414)3.54832283
18hippo signaling (GO:0035329)3.51805686
19establishment of planar polarity (GO:0001736)3.49488701
20establishment of tissue polarity (GO:0007164)3.49488701
21regulation of establishment of planar polarity (GO:0090175)3.42289320
22negative regulation of axon extension involved in axon guidance (GO:0048843)3.39078499
23lung-associated mesenchyme development (GO:0060484)3.29822325
24keratinization (GO:0031424)3.24853819
25DNA unwinding involved in DNA replication (GO:0006268)3.24549477
26notochord development (GO:0030903)3.24168774
27collecting duct development (GO:0072044)3.21236832
28negative regulation of chondrocyte differentiation (GO:0032331)3.19263520
29mesenchymal to epithelial transition (GO:0060231)3.18493138
30regulation of heart morphogenesis (GO:2000826)3.18489370
31eyelid development in camera-type eye (GO:0061029)3.17692534
32bone trabecula formation (GO:0060346)3.15348144
33regulation of catenin import into nucleus (GO:0035412)3.14105856
34middle ear morphogenesis (GO:0042474)3.12139936
35body morphogenesis (GO:0010171)3.09915224
36mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.08014133
37neuron projection extension involved in neuron projection guidance (GO:1902284)3.04525874
38axon extension involved in axon guidance (GO:0048846)3.04525874
39plasma membrane repair (GO:0001778)3.03117855
40embryonic cranial skeleton morphogenesis (GO:0048701)2.96941187
41convergent extension (GO:0060026)2.94279235
42embryonic skeletal joint morphogenesis (GO:0060272)2.93973391
43regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.93114244
44protein heterotrimerization (GO:0070208)2.92996107
45regulation of hippo signaling (GO:0035330)2.92236473
46nucleosome disassembly (GO:0006337)2.91348260
47protein-DNA complex disassembly (GO:0032986)2.91348260
48mesenchyme morphogenesis (GO:0072132)2.89344949
49negative regulation of cell fate specification (GO:0009996)2.88088834
50regulation of axon extension involved in axon guidance (GO:0048841)2.87770884
51negative regulation of axon guidance (GO:1902668)2.86504735
52gastrulation with mouth forming second (GO:0001702)2.86275495
53ectoderm development (GO:0007398)2.85516152
54skin morphogenesis (GO:0043589)2.85059428
55pattern specification involved in kidney development (GO:0061004)2.84127375
56negative regulation of cartilage development (GO:0061037)2.83513794
57organ induction (GO:0001759)2.82781487
58basement membrane organization (GO:0071711)2.82437022
59cell migration in hindbrain (GO:0021535)2.82383619
60endocardial cushion morphogenesis (GO:0003203)2.81820718
61embryonic body morphogenesis (GO:0010172)2.81230339
62molting cycle (GO:0042303)2.80644271
63hair cycle (GO:0042633)2.80644271
64midgut development (GO:0007494)2.80520747
65hindlimb morphogenesis (GO:0035137)2.79720165
66ephrin receptor signaling pathway (GO:0048013)2.78271954
67negative regulation of embryonic development (GO:0045992)2.76614660
68semaphorin-plexin signaling pathway (GO:0071526)2.74629059
69regulation of mammary gland epithelial cell proliferation (GO:0033599)2.74542988
70embryonic camera-type eye development (GO:0031076)2.73629328
71heart valve formation (GO:0003188)2.73063619
72protein complex localization (GO:0031503)2.72643106
73regulation of translational fidelity (GO:0006450)2.72341934
74adherens junction assembly (GO:0034333)2.72184604
75regulation of secondary heart field cardioblast proliferation (GO:0003266)2.69832611
76regulation of cardioblast proliferation (GO:0003264)2.69832611
77craniofacial suture morphogenesis (GO:0097094)2.68512426
78branching involved in salivary gland morphogenesis (GO:0060445)2.67092539
79mesenchyme development (GO:0060485)2.67030887
80pyrimidine nucleobase catabolic process (GO:0006208)2.65251100
81dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.63981965
82cell surface receptor signaling pathway involved in heart development (GO:0061311)2.63962893
83keratinocyte differentiation (GO:0030216)2.63166062
84keratinocyte proliferation (GO:0043616)2.62418148
85embryonic eye morphogenesis (GO:0048048)2.61279695
86regulation of transforming growth factor beta2 production (GO:0032909)2.60743122
87cellular protein complex localization (GO:0034629)2.60380865
88regulation of axon guidance (GO:1902667)2.59788756
89eye morphogenesis (GO:0048592)2.59267307
90embryonic hindlimb morphogenesis (GO:0035116)2.59215815
91negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.58023864
92epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.57988179
93chondrocyte proliferation (GO:0035988)2.57889574
94atrioventricular valve morphogenesis (GO:0003181)2.57847648
95regulation of cardioblast differentiation (GO:0051890)2.57042626
96peptidyl-arginine omega-N-methylation (GO:0035247)2.56840240
97camera-type eye morphogenesis (GO:0048593)2.56596771
98multicellular organismal water homeostasis (GO:0050891)2.56414039
99lymph vessel development (GO:0001945)2.55042667
100dorsal/ventral axis specification (GO:0009950)2.54995780
101segment specification (GO:0007379)2.54938834
102metanephric mesenchyme development (GO:0072075)2.54452687
103positive regulation of catenin import into nucleus (GO:0035413)2.53180068
104regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.52701410
105neural tube development (GO:0021915)2.52473170
106kidney mesenchyme development (GO:0072074)2.51757093
107regulation of cell fate specification (GO:0042659)2.50066407
108positive regulation of embryonic development (GO:0040019)2.49744567
109head development (GO:0060322)2.49573701
110maternal placenta development (GO:0001893)2.49484153
111collagen fibril organization (GO:0030199)2.48926387
112L-serine metabolic process (GO:0006563)2.47374597
113establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.47283063
114epithelial cell-cell adhesion (GO:0090136)2.45962355
115forelimb morphogenesis (GO:0035136)2.45394667
116embryonic forelimb morphogenesis (GO:0035115)2.45371530
117layer formation in cerebral cortex (GO:0021819)2.45360212
118proline biosynthetic process (GO:0006561)2.45217213
119regulation of gastrulation (GO:0010470)2.44513918
120embryonic camera-type eye morphogenesis (GO:0048596)2.44257299
121heterochromatin organization (GO:0070828)2.44071833
122morphogenesis of an epithelial sheet (GO:0002011)2.43515990
123regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.43214173
124positive regulation of fatty acid beta-oxidation (GO:0032000)2.43093006
125aorta morphogenesis (GO:0035909)2.42621831
126establishment of apical/basal cell polarity (GO:0035089)2.42097973
127regulation of mesenchymal cell apoptotic process (GO:2001053)2.41562447
128face development (GO:0060324)2.41261372
129establishment or maintenance of monopolar cell polarity (GO:0061339)2.40743889
130peptidyl-arginine methylation (GO:0018216)2.40233536
131peptidyl-arginine N-methylation (GO:0035246)2.40233536
132gap junction assembly (GO:0016264)2.39513282
133apical protein localization (GO:0045176)2.34267026
134cell-cell junction maintenance (GO:0045217)2.30869864
135mitotic chromosome condensation (GO:0007076)2.30376468
136asymmetric protein localization (GO:0008105)2.29639634
137histone arginine methylation (GO:0034969)2.28403682
138focal adhesion assembly (GO:0048041)2.28195148
139cell-substrate adherens junction assembly (GO:0007045)2.28195148
140establishment of monopolar cell polarity (GO:0061162)2.27899177
141cell migration involved in sprouting angiogenesis (GO:0002042)2.25968191
142positive regulation of cell cycle G2/M phase transition (GO:1902751)2.24383394
143positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.24383394
144cytoskeletal anchoring at plasma membrane (GO:0007016)2.23446733
145ventricular trabecula myocardium morphogenesis (GO:0003222)2.22633907
146regulation of NFAT protein import into nucleus (GO:0051532)2.22210785
147cell-substrate junction assembly (GO:0007044)2.21932653
148prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.20850918
149protein retention in ER lumen (GO:0006621)2.20155406
150ectodermal placode formation (GO:0060788)2.18048736
151pre-miRNA processing (GO:0031054)2.14606455
152myelination in peripheral nervous system (GO:0022011)2.13943443
153peripheral nervous system axon ensheathment (GO:0032292)2.13943443
154neuron cell-cell adhesion (GO:0007158)2.13448301
155atrial septum morphogenesis (GO:0060413)2.12228309
156vascular endothelial growth factor signaling pathway (GO:0038084)2.10712752

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.92338404
2E2F7_22180533_ChIP-Seq_HELA_Human4.12526324
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.61747079
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.59673945
5ZNF263_19887448_ChIP-Seq_K562_Human2.45888156
6TP53_20018659_ChIP-ChIP_R1E_Mouse2.37540321
7ZFP281_18757296_ChIP-ChIP_E14_Mouse2.25609353
8ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.20919020
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.17757980
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.15634449
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.13955458
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.09022873
13* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.07281713
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.98687009
15EED_16625203_ChIP-ChIP_MESCs_Mouse1.96442792
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.93975891
17ERG_21242973_ChIP-ChIP_JURKAT_Human1.92135507
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.91622895
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.88214626
20EZH2_18974828_ChIP-Seq_MESCs_Mouse1.87838272
21RNF2_18974828_ChIP-Seq_MESCs_Mouse1.87838272
22CLOCK_20551151_ChIP-Seq_293T_Human1.82833926
23SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.82021097
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.80477484
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77015042
26PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.72763574
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.67728137
28RING1B_27294783_Chip-Seq_NPCs_Mouse1.66288947
29ZFP281_27345836_Chip-Seq_ESCs_Mouse1.59638002
30SOX9_24532713_ChIP-Seq_HFSC_Mouse1.59337577
31HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.55072689
32* RNF2_27304074_Chip-Seq_ESCs_Mouse1.54616085
33* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.54362664
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54235799
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.54129294
36ISL1_27105846_Chip-Seq_CPCs_Mouse1.53011184
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.52275483
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.51188740
39CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.50802034
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.50387474
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48723456
42* EZH2_27294783_Chip-Seq_ESCs_Mouse1.46095181
43RING1B_27294783_Chip-Seq_ESCs_Mouse1.45916507
44UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.45483609
45* KDM2B_26808549_Chip-Seq_K562_Human1.45124589
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44692361
47TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.43653240
48* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42360776
49* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42331522
50AR_21909140_ChIP-Seq_LNCAP_Human1.39677029
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38538953
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36434598
53XRN2_22483619_ChIP-Seq_HELA_Human1.35349260
54* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34092488
55EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.34049594
56TCF3_18692474_ChIP-Seq_MEFs_Mouse1.33481580
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.33450758
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.33183962
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.33148650
60ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.32511078
61P300_27058665_Chip-Seq_ZR-75-30cells_Human1.30446583
62RACK7_27058665_Chip-Seq_MCF-7_Human1.29906449
63FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.29402053
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29276407
65* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.29263813
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28882480
67SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.28545102
68PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27973512
69CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27878173
70OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.27361774
71CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27124477
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27086501
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23513028
74LXR_22292898_ChIP-Seq_THP-1_Human1.22363776
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21982303
76* CTCF_27219007_Chip-Seq_Bcells_Human1.20738099
77MYC_22102868_ChIP-Seq_BL_Human1.20285454
78DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19063039
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18585142
80SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.17504946
81* CREB1_26743006_Chip-Seq_LNCaP_Human1.17164268
82RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17079920
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15879754
84SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.14680119
85CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14513253
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13520868
87NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13336558
88SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.12035210
89WT1_19549856_ChIP-ChIP_CCG9911_Human1.11335411
90CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11165147
91KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10936023
92NANOG_21062744_ChIP-ChIP_HESCs_Human1.10581139
93MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.10373939
94E2F1_21310950_ChIP-Seq_MCF-7_Human1.10301653
95* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08379116
96* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.08189940
97ATF3_27146783_Chip-Seq_COLON_Human1.06268984
98P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05883127
99DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05569275
100ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05544296
101FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.04224373
102KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.03755138
103KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.03755138
104KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.03755138
105* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03147855
106KDM2B_26808549_Chip-Seq_JURKAT_Human1.02276185
107POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02048932
108* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01894429
109MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01176714
110* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00972279
111KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00897774
112RUNX1_27514584_Chip-Seq_MCF-7_Human1.00766070
113KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00257784
114* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.00219155
115MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00009821
116UBF1/2_26484160_Chip-Seq_HMECs_Human0.99972485
117KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99000250
118TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98048213
119TCF3_18692474_ChIP-Seq_MESCs_Mouse0.97519937
120* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.97212196
121* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96251804
122POU5F1_16518401_ChIP-PET_MESCs_Mouse0.96056392
123POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95636519
124BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95496898
125* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94686233
126TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.93542808
127EZH2_22144423_ChIP-Seq_EOC_Human0.93251598
128NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92808979
129ELK3_25401928_ChIP-Seq_HUVEC_Human0.92593259
130KDM2B_26808549_Chip-Seq_DND41_Human0.92293032
131ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91555754
132WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88999655

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.03936696
2MP0003705_abnormal_hypodermis_morpholog3.47652862
3MP0003941_abnormal_skin_development3.15642023
4MP0009053_abnormal_anal_canal3.00216690
5MP0005275_abnormal_skin_tensile2.84528847
6MP0000537_abnormal_urethra_morphology2.76660712
7MP0002796_impaired_skin_barrier2.62898140
8MP0000579_abnormal_nail_morphology2.20221741
9MP0002249_abnormal_larynx_morphology2.16882060
10MP0000762_abnormal_tongue_morphology2.12543444
11MP0003136_yellow_coat_color2.11980150
12MP0003385_abnormal_body_wall2.06071241
13MP0000566_synostosis1.99905101
14MP0009250_abnormal_appendicular_skeleto1.99859406
15MP0009379_abnormal_foot_pigmentation1.98064605
16MP0000049_abnormal_middle_ear1.96092635
17MP0003942_abnormal_urinary_system1.93821300
18MP0005409_darkened_coat_color1.87557484
19MP0005171_absent_coat_pigmentation1.87212222
20MP0002282_abnormal_trachea_morphology1.84533485
21MP0003755_abnormal_palate_morphology1.83117537
22MP0002234_abnormal_pharynx_morphology1.81367444
23MP0005503_abnormal_tendon_morphology1.79677739
24MP0000534_abnormal_ureter_morphology1.77999336
25MP0008789_abnormal_olfactory_epithelium1.74067408
26MP0002060_abnormal_skin_morphology1.64710693
27MP0005501_abnormal_skin_physiology1.64559335
28MP0004145_abnormal_muscle_electrophysio1.60104959
29MP0008438_abnormal_cutaneous_collagen1.59913618
30MP0002653_abnormal_ependyma_morphology1.59773030
31MP0000467_abnormal_esophagus_morphology1.58463472
32MP0000428_abnormal_craniofacial_morphol1.57577427
33MP0003119_abnormal_digestive_system1.57151425
34MP0003937_abnormal_limbs/digits/tail_de1.56784034
35MP0001346_abnormal_lacrimal_gland1.53419167
36MP0000733_abnormal_muscle_development1.53290313
37MP0005248_abnormal_Harderian_gland1.52388698
38MP0002233_abnormal_nose_morphology1.51484288
39MP0010234_abnormal_vibrissa_follicle1.48684671
40MP0000647_abnormal_sebaceous_gland1.46708521
41MP0005257_abnormal_intraocular_pressure1.45287705
42MP0002932_abnormal_joint_morphology1.45241266
43MP0005187_abnormal_penis_morphology1.42743358
44MP0004233_abnormal_muscle_weight1.39712524
45MP0003890_abnormal_embryonic-extraembry1.38138184
46MP0000383_abnormal_hair_follicle1.35815102
47MP0004185_abnormal_adipocyte_glucose1.35356109
48MP0005508_abnormal_skeleton_morphology1.34858437
49MP0002254_reproductive_system_inflammat1.34127596
50MP0002098_abnormal_vibrissa_morphology1.33736305
51MP0005076_abnormal_cell_differentiation1.33435462
52MP0001849_ear_inflammation1.32967085
53MP0004272_abnormal_basement_membrane1.32791141
54MP0000516_abnormal_urinary_system1.31591974
55MP0005367_renal/urinary_system_phenotyp1.31591974
56MP0000678_abnormal_parathyroid_gland1.31358188
57MP0002116_abnormal_craniofacial_bone1.29236402
58MP0000751_myopathy1.28003204
59MP0003123_paternal_imprinting1.26381016
60MP0003935_abnormal_craniofacial_develop1.25012008
61MP0010368_abnormal_lymphatic_system1.24573740
62MP0001299_abnormal_eye_distance/1.23952968
63MP0003115_abnormal_respiratory_system1.23243185
64MP0003283_abnormal_digestive_organ1.21735582
65MP0008932_abnormal_embryonic_tissue1.20185456
66MP0004858_abnormal_nervous_system1.20104543
67MP0002108_abnormal_muscle_morphology1.20007391
68MP0001340_abnormal_eyelid_morphology1.19179827
69MP0000377_abnormal_hair_follicle1.19094576
70MP0002085_abnormal_embryonic_tissue1.15866102
71MP0002697_abnormal_eye_size1.15359958
72MP0005623_abnormal_meninges_morphology1.14973308
73MP0005499_abnormal_olfactory_system1.14832831
74MP0005394_taste/olfaction_phenotype1.14832831
75MP0002111_abnormal_tail_morphology1.13982692
76MP0001216_abnormal_epidermal_layer1.13601604
77MP0010771_integument_phenotype1.10562697
78MP0003938_abnormal_ear_development1.10463193
79MP0003122_maternal_imprinting1.10110739
80MP0003315_abnormal_perineum_morphology1.10099349
81MP0010678_abnormal_skin_adnexa1.09582611
82MP0010352_gastrointestinal_tract_polyps1.09034847
83MP0000759_abnormal_skeletal_muscle1.08616732
84MP0000427_abnormal_hair_cycle1.07955806
85MP0003111_abnormal_nucleus_morphology1.06747346
86MP0004885_abnormal_endolymph1.05056110
87MP0002896_abnormal_bone_mineralization1.04335355
88MP0002177_abnormal_outer_ear1.02252767
89MP0002109_abnormal_limb_morphology1.01656230
90MP0003011_delayed_dark_adaptation1.01392943
91MP0000432_abnormal_head_morphology1.00379044
92MP0000778_abnormal_nervous_system0.98122227
93MP0000750_abnormal_muscle_regeneration0.97558490
94MP0001286_abnormal_eye_development0.97451753
95MP0004957_abnormal_blastocyst_morpholog0.97329407
96MP0002114_abnormal_axial_skeleton0.96207243
97MP0009384_cardiac_valve_regurgitation0.94682218
98MP0000163_abnormal_cartilage_morphology0.94407279
99MP0002092_abnormal_eye_morphology0.94200656
100MP0004197_abnormal_fetal_growth/weight/0.93887316
101MP0003861_abnormal_nervous_system0.92802109
102MP0005380_embryogenesis_phenotype0.92733633
103MP0001672_abnormal_embryogenesis/_devel0.92733633
104MP0004859_abnormal_synaptic_plasticity0.92648310
105MP0001730_embryonic_growth_arrest0.90956838
106MP0003077_abnormal_cell_cycle0.90492189
107MP0006138_congestive_heart_failure0.90472220
108MP0001188_hyperpigmentation0.90189796
109MP0003566_abnormal_cell_adhesion0.89705400
110MP0002009_preneoplasia0.88833275
111MP0001879_abnormal_lymphatic_vessel0.88392111
112MP0002938_white_spotting0.88035470
113MP0000462_abnormal_digestive_system0.87860417
114MP0001293_anophthalmia0.87305890
115MP0004381_abnormal_hair_follicle0.86555642
116MP0003453_abnormal_keratinocyte_physiol0.86416110
117MP0004133_heterotaxia0.86199396
118MP0003984_embryonic_growth_retardation0.85573707
119MP0002089_abnormal_postnatal_growth/wei0.84651410
120MP0002081_perinatal_lethality0.84085833
121MP0001348_abnormal_lacrimal_gland0.84004027
122MP0002084_abnormal_developmental_patter0.82716878
123MP0002877_abnormal_melanocyte_morpholog0.82420805
124MP0009672_abnormal_birth_weight0.82390660
125MP0002088_abnormal_embryonic_growth/wei0.81602698
126MP0000350_abnormal_cell_proliferation0.80420192

Predicted human phenotypes

RankGene SetZ-score
1Type 1 muscle fiber predominance (HP:0003803)3.59806849
2Shallow orbits (HP:0000586)3.35246120
3Fragile nails (HP:0001808)3.26998520
4Protrusio acetabuli (HP:0003179)3.22093882
5Short 4th metacarpal (HP:0010044)3.16526147
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.16526147
7Premature rupture of membranes (HP:0001788)3.02744969
8Ulnar bowing (HP:0003031)2.99733397
9Muscle fiber inclusion bodies (HP:0100299)2.91873291
10Increased connective tissue (HP:0009025)2.86730398
11Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.84951444
12Calcaneovalgus deformity (HP:0001848)2.84591002
13Hypotrichosis (HP:0001006)2.84335643
14Atrophic scars (HP:0001075)2.83615971
15Hyperacusis (HP:0010780)2.82078185
16Morphological abnormality of the middle ear (HP:0008609)2.75472454
17Round ear (HP:0100830)2.72125187
18Deformed tarsal bones (HP:0008119)2.71635868
19Abnormality of the 4th metacarpal (HP:0010012)2.69153050
20Natal tooth (HP:0000695)2.66815801
21Myopathic facies (HP:0002058)2.57500340
22Nemaline bodies (HP:0003798)2.54929266
23Abnormality of the phalanges of the hallux (HP:0010057)2.53432096
24Neonatal short-limb short stature (HP:0008921)2.51533461
25High anterior hairline (HP:0009890)2.49367718
26Advanced eruption of teeth (HP:0006288)2.47024714
27Abnormality of the distal phalanx of the thumb (HP:0009617)2.45925989
28Exercise-induced myalgia (HP:0003738)2.44321025
29Partial duplication of the phalanx of hand (HP:0009999)2.44040457
30Absent phalangeal crease (HP:0006109)2.43832836
31Bronchomalacia (HP:0002780)2.42239316
32Milia (HP:0001056)2.41968384
33Down-sloping shoulders (HP:0200021)2.41278676
34Distal arthrogryposis (HP:0005684)2.39492028
35Shoulder girdle muscle weakness (HP:0003547)2.38629563
36Renal duplication (HP:0000075)2.36384794
37Partial duplication of thumb phalanx (HP:0009944)2.36115430
38Woolly hair (HP:0002224)2.33885803
39Concave nail (HP:0001598)2.32007269
40Right ventricular cardiomyopathy (HP:0011663)2.30838252
41Pelvic girdle muscle weakness (HP:0003749)2.28482554
42Coronal craniosynostosis (HP:0004440)2.26408646
43Abnormality of the aortic arch (HP:0012303)2.22851961
44Lip pit (HP:0100267)2.22497594
45Hepatoblastoma (HP:0002884)2.20919583
46Thin ribs (HP:0000883)2.20071609
47Vertebral arch anomaly (HP:0008438)2.12937911
48Hyporeflexia of lower limbs (HP:0002600)2.10563818
49Fragile skin (HP:0001030)2.10011330
50Abnormality of the calcaneus (HP:0008364)2.08859243
51Turricephaly (HP:0000262)2.08645500
52Hypoplastic labia majora (HP:0000059)2.08374527
53Cerebral aneurysm (HP:0004944)2.05723921
54Pili torti (HP:0003777)2.04826090
55Increased variability in muscle fiber diameter (HP:0003557)2.04658409
56Missing ribs (HP:0000921)2.03984419
57Septate vagina (HP:0001153)2.03340728
58Abnormality of the hip-girdle musculature (HP:0001445)2.02911291
59Abnormality of the musculature of the pelvis (HP:0001469)2.02911291
60Spinal rigidity (HP:0003306)2.02873647
61Cutaneous finger syndactyly (HP:0010554)2.02719553
62Broad face (HP:0000283)2.01595781
63Abnormal finger flexion creases (HP:0006143)2.01544396
64Morphological abnormality of the inner ear (HP:0011390)2.00690014
65Ankle contracture (HP:0006466)2.00512983
66Plantar hyperkeratosis (HP:0007556)2.00312596
67Selective tooth agenesis (HP:0001592)1.99859266
68Asymmetry of the thorax (HP:0001555)1.97368371
69Wide anterior fontanel (HP:0000260)1.96262093
70Broad metatarsal (HP:0001783)1.95245978
71Anophthalmia (HP:0000528)1.93863600
72Achilles tendon contracture (HP:0001771)1.93454457
73Overriding aorta (HP:0002623)1.91043043
74Difficulty climbing stairs (HP:0003551)1.90843996
75Abnormality of nail color (HP:0100643)1.90822219
76Increased nuchal translucency (HP:0010880)1.90456103
77Abnormality of skeletal muscle fiber size (HP:0012084)1.90390825
78Scapular winging (HP:0003691)1.89563329
79Abnormality of the labia majora (HP:0012881)1.89371513
80Arnold-Chiari malformation (HP:0002308)1.89249231
81Disproportionate tall stature (HP:0001519)1.88142745
82Aplasia involving bones of the extremities (HP:0009825)1.87101124
83Aplasia involving bones of the upper limbs (HP:0009823)1.87101124
84Aplasia of the phalanges of the hand (HP:0009802)1.87101124
85Esophageal atresia (HP:0002032)1.87040563
86Difficulty running (HP:0009046)1.85263995
87Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.85198833
88Mildly elevated creatine phosphokinase (HP:0008180)1.84752116
89Broad distal phalanx of finger (HP:0009836)1.84732157
90Ulnar deviation of the wrist (HP:0003049)1.83854295
91Germ cell neoplasia (HP:0100728)1.83467912
92Bladder diverticulum (HP:0000015)1.83454115
93Abnormal number of incisors (HP:0011064)1.83432073
94Exercise-induced muscle cramps (HP:0003710)1.83355525
95Mitral regurgitation (HP:0001653)1.82809341
9611 pairs of ribs (HP:0000878)1.82533874
97Deviation of the hallux (HP:0010051)1.82322797
98Abnormality of the Achilles tendon (HP:0005109)1.81090765
99Pterygium (HP:0001059)1.79792122
100Skull defect (HP:0001362)1.78992139
101Abnormality of the salivary glands (HP:0010286)1.78377503
102Cutaneous syndactyly (HP:0012725)1.78232642
103Wrist flexion contracture (HP:0001239)1.77208413
104Tarsal synostosis (HP:0008368)1.77122562
105Elfin facies (HP:0004428)1.75462193
106Vitreoretinal degeneration (HP:0000655)1.74087291
107Duplication of thumb phalanx (HP:0009942)1.73615056
108Insomnia (HP:0100785)1.73224168
109Abnormality of dentin (HP:0010299)1.72779634
110Choanal stenosis (HP:0000452)1.72256250
111Ulnar deviation of finger (HP:0009465)1.70659961
112Genu recurvatum (HP:0002816)1.70595826
113Hallux valgus (HP:0001822)1.69717526
114Patellar dislocation (HP:0002999)1.69569079
115Broad toe (HP:0001837)1.69254567
116Chorioretinal atrophy (HP:0000533)1.69101970
117Microglossia (HP:0000171)1.68860371
118Megalencephaly (HP:0001355)1.68596606
119Absent eyelashes (HP:0000561)1.68019660
120Atresia of the external auditory canal (HP:0000413)1.67953771
121Bowel diverticulosis (HP:0005222)1.67302005
122Abnormality of the lacrimal duct (HP:0011481)1.67118860
123Abnormality of the parietal bone (HP:0002696)1.66856003
124Mesomelia (HP:0003027)1.65754168
125Limb-girdle muscle weakness (HP:0003325)1.65414226
126Short palpebral fissure (HP:0012745)1.64456012
127Synostosis involving bones of the feet (HP:0009140)1.64232939
128Synostosis involving bones of the lower limbs (HP:0009138)1.64232939
129Muscle fiber splitting (HP:0003555)1.63994231
130Broad phalanges of the hand (HP:0009768)1.63157869
131Nasolacrimal duct obstruction (HP:0000579)1.62341562
132Mitral valve prolapse (HP:0001634)1.62317745
133Broad thumb (HP:0011304)1.61838619
134Buphthalmos (HP:0000557)1.61804749
135Obstructive sleep apnea (HP:0002870)1.61533587
136Back pain (HP:0003418)1.61518686
137Overgrowth (HP:0001548)1.60692504
138Adducted thumb (HP:0001181)1.60484081
139Abnormality of the distal phalanges of the toes (HP:0010182)1.60439130
140Broad finger (HP:0001500)1.60408644
141Abnormality of the shoulder girdle musculature (HP:0001435)1.59849407
142Midline defect of the nose (HP:0004122)1.59804287
143Deviation of the thumb (HP:0009603)1.59427803
144Abnormality of the nasolacrimal system (HP:0000614)1.59411063
145Broad long bones (HP:0005622)1.59338002
146Abnormality of cochlea (HP:0000375)1.59188996
147Laryngomalacia (HP:0001601)1.56856647
148Renovascular hypertension (HP:0100817)1.55681670
149Proximal placement of thumb (HP:0009623)1.53996375
150Biconcave vertebral bodies (HP:0004586)1.53410420
151Broad phalanx (HP:0006009)1.52113406
152Hypopigmentation of the fundus (HP:0007894)1.50253661
153Midface retrusion (HP:0011800)1.50095446
154Pointed chin (HP:0000307)1.49821852
155Tracheal stenosis (HP:0002777)1.49544810
156Preaxial foot polydactyly (HP:0001841)1.49411320
157Bowing of the arm (HP:0006488)1.49261154
158Bowed forearm bones (HP:0003956)1.49261154
159Renal dysplasia (HP:0000110)1.47105372
160Glossoptosis (HP:0000162)1.45910904

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB23.95825512
2TRIB33.88077078
3LATS23.12320120
4LATS12.90417205
5TTN2.75049265
6DDR22.60415830
7SMG12.48968488
8PDGFRA2.27609420
9ERBB32.26901731
10MAP3K102.09007951
11PHKG12.08645943
12PHKG22.08645943
13MST1R2.04513210
14PKN21.99590225
15MARK11.98398240
16NTRK11.90304852
17CDC71.72151620
18NME11.70940002
19EEF2K1.66856783
20SIK11.63559174
21KSR11.60317051
22FER1.52703777
23OBSCN1.46909852
24DYRK1B1.46468805
25MET1.46328040
26PTK61.42724944
27PNCK1.42303776
28STK38L1.40084788
29CAMK1G1.30739606
30EPHA21.29423601
31ICK1.23260962
32ILK1.21257943
33FGFR21.21151494
34PIK3CG1.20767997
35ERN11.19315754
36RPS6KB21.18466063
37MTOR1.17575664
38DYRK31.14995226
39DYRK21.13663547
40NEK11.13026424
41FGFR11.12624186
42RIPK11.07326040
43ERBB21.06804170
44CDK71.05906689
45EPHA31.04272175
46WEE11.03478112
47CAMK1D1.03031130
48MAPKAPK30.99267291
49DMPK0.99096943
50PAK20.98111208
51PAK60.97855868
52CDK80.97834536
53PTK20.95567703
54MKNK10.94662655
55TYRO30.94404234
56MAP3K30.94072778
57PRKCI0.90005668
58PRKD30.89945084
59NME20.87459565
60TAOK20.85901403
61NTRK20.85187429
62LIMK10.84117815
63MAP3K20.83508301
64CHEK20.82371611
65PAK30.81536654
66IRAK30.80525353
67BMX0.78153629
68LMTK20.76182234
69RPS6KL10.76127989
70RPS6KC10.76127989
71MARK20.74904956
72TIE10.71397269
73CASK0.70000091
74TAOK10.68432682
75BUB10.67529808
76LRRK20.67196154
77SRPK10.67095472
78CDC42BPA0.66987814
79MAP3K60.65500213
80UHMK10.65029023
81CDK60.64662125
82TLK10.64086536
83RPS6KA10.61940933
84PAK40.61309302
85MAP2K20.60980417
86TAF10.60871999
87ATR0.59765379
88MAP2K10.59548681
89ROCK10.59431603
90AKT20.59257612
91RPS6KA20.59128642
92MINK10.58031258
93BCR0.57906712
94RPS6KA60.56589704
95BRD40.56564480
96EPHA40.55403602
97CHEK10.53790416
98MKNK20.53614275
99AURKA0.51740942
100CSNK1E0.51692353
101BRSK10.51564731
102PBK0.51549842
103CDK10.50892525
104CDK20.50610262
105IRAK20.50337121
106MAP2K40.48560405
107AURKB0.48126130
108VRK20.47841604
109CDK11A0.46662446
110CDK150.46448274
111GSK3A0.46334143
112MAP3K70.45207602
113STK30.44777491
114PLK40.44772027
115PRPF4B0.44246720
116MAPK150.43299701
117CDK180.42643970
118KDR0.42589372
119CDK120.42565133
120ERBB40.42343729
121RET0.42236803
122KSR20.42177836
123CSNK1D0.41875676
124FGFR40.40653668
125PRKCZ0.39655251
126PRKD20.38801997
127CSNK1G10.38320325
128* MAPK90.37411598
129RPS6KA40.37391244
130NEK20.37022296
131* GSK3B0.36831275
132BCKDK0.35328020
133ADRBK10.35076611
134PDGFRB0.34886463
135TESK10.34828737
136STK380.34656199
137MAPK130.34488022
138TGFBR10.34144591
139MAPK120.33100675
140TTK0.32490823
141MAPK80.30938610
142CSNK1A1L0.29024221
143MAPK110.28738565
144SIK20.28605970
145MAPKAPK20.27965184

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052174.24207891
2Hedgehog signaling pathway_Homo sapiens_hsa043403.27989764
3Hippo signaling pathway_Homo sapiens_hsa043902.94741338
4Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.51353656
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.25211684
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.13682608
7Axon guidance_Homo sapiens_hsa043602.09769587
8Melanogenesis_Homo sapiens_hsa049162.08545785
9Wnt signaling pathway_Homo sapiens_hsa043101.91436498
10Bladder cancer_Homo sapiens_hsa052191.87779359
11DNA replication_Homo sapiens_hsa030301.83095094
12ECM-receptor interaction_Homo sapiens_hsa045121.81567247
13Tight junction_Homo sapiens_hsa045301.77470991
14Adherens junction_Homo sapiens_hsa045201.77199742
15Proteoglycans in cancer_Homo sapiens_hsa052051.76587338
16Notch signaling pathway_Homo sapiens_hsa043301.59621028
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.59008147
18TGF-beta signaling pathway_Homo sapiens_hsa043501.57618849
19MicroRNAs in cancer_Homo sapiens_hsa052061.50294513
20Endometrial cancer_Homo sapiens_hsa052131.44197562
21Focal adhesion_Homo sapiens_hsa045101.43729548
22Phototransduction_Homo sapiens_hsa047441.38929941
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.30169821
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28022034
25Dilated cardiomyopathy_Homo sapiens_hsa054141.25841057
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24763990
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.20790474
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.20080802
29Insulin signaling pathway_Homo sapiens_hsa049101.17431429
30mTOR signaling pathway_Homo sapiens_hsa041501.15505634
31Melanoma_Homo sapiens_hsa052181.13929743
32Glucagon signaling pathway_Homo sapiens_hsa049221.12571640
33AMPK signaling pathway_Homo sapiens_hsa041521.12229047
34Glioma_Homo sapiens_hsa052141.06156000
35Base excision repair_Homo sapiens_hsa034101.05783319
36Insulin resistance_Homo sapiens_hsa049311.03117862
37Gap junction_Homo sapiens_hsa045401.02291929
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02064362
39Lysine degradation_Homo sapiens_hsa003101.01744012
40GnRH signaling pathway_Homo sapiens_hsa049121.01498979
41Thyroid cancer_Homo sapiens_hsa052161.00942986
42Protein digestion and absorption_Homo sapiens_hsa049740.99667566
43Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98331662
44Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.97994816
45Renal cell carcinoma_Homo sapiens_hsa052110.96345769
46Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94701195
47Chronic myeloid leukemia_Homo sapiens_hsa052200.94414186
48Estrogen signaling pathway_Homo sapiens_hsa049150.93530873
49Pathways in cancer_Homo sapiens_hsa052000.91020071
50Vitamin B6 metabolism_Homo sapiens_hsa007500.90000637
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89363710
52Pancreatic cancer_Homo sapiens_hsa052120.89240124
53VEGF signaling pathway_Homo sapiens_hsa043700.88044117
54Inositol phosphate metabolism_Homo sapiens_hsa005620.84146621
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83053860
56mRNA surveillance pathway_Homo sapiens_hsa030150.82647080
57Mismatch repair_Homo sapiens_hsa034300.82272773
58Amoebiasis_Homo sapiens_hsa051460.82259105
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.81968633
60Oxytocin signaling pathway_Homo sapiens_hsa049210.81726263
61HTLV-I infection_Homo sapiens_hsa051660.81302461
62Small cell lung cancer_Homo sapiens_hsa052220.77874745
63Prostate cancer_Homo sapiens_hsa052150.75547313
64ErbB signaling pathway_Homo sapiens_hsa040120.75375314
65Prion diseases_Homo sapiens_hsa050200.75098419
66Colorectal cancer_Homo sapiens_hsa052100.74789149
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74480795
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70646532
69Rap1 signaling pathway_Homo sapiens_hsa040150.70329391
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70090836
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69696748
72Non-small cell lung cancer_Homo sapiens_hsa052230.69132221
73PI3K-Akt signaling pathway_Homo sapiens_hsa041510.68005382
74Phenylalanine metabolism_Homo sapiens_hsa003600.67982485
75PPAR signaling pathway_Homo sapiens_hsa033200.67727132
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66949899
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64364472
78Butanoate metabolism_Homo sapiens_hsa006500.64344516
79Fanconi anemia pathway_Homo sapiens_hsa034600.63921357
80Tyrosine metabolism_Homo sapiens_hsa003500.63541322
81Circadian rhythm_Homo sapiens_hsa047100.63217472
82Long-term potentiation_Homo sapiens_hsa047200.61558265
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61086224
84Nucleotide excision repair_Homo sapiens_hsa034200.60974790
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60069158
86Sulfur relay system_Homo sapiens_hsa041220.59189908
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58787859
88Fatty acid biosynthesis_Homo sapiens_hsa000610.58441471
89Fatty acid degradation_Homo sapiens_hsa000710.58074346
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56617750
91Fatty acid metabolism_Homo sapiens_hsa012120.56230734
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56097112
93One carbon pool by folate_Homo sapiens_hsa006700.55870078
94Acute myeloid leukemia_Homo sapiens_hsa052210.54187747
95FoxO signaling pathway_Homo sapiens_hsa040680.52343842
96Oocyte meiosis_Homo sapiens_hsa041140.52167780
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51799861
98Pentose phosphate pathway_Homo sapiens_hsa000300.50843671
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.50742711
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50008610
101Biosynthesis of amino acids_Homo sapiens_hsa012300.49385153
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48772747
103Ras signaling pathway_Homo sapiens_hsa040140.47985033
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46858950
105Long-term depression_Homo sapiens_hsa047300.46626257
106p53 signaling pathway_Homo sapiens_hsa041150.46196095
107Choline metabolism in cancer_Homo sapiens_hsa052310.45884826
108Glutamatergic synapse_Homo sapiens_hsa047240.45705290
109Cholinergic synapse_Homo sapiens_hsa047250.45609113
110Arginine biosynthesis_Homo sapiens_hsa002200.45546526
111Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44413944
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44055030
113Cocaine addiction_Homo sapiens_hsa050300.43939518
114Spliceosome_Homo sapiens_hsa030400.43852225
115RNA transport_Homo sapiens_hsa030130.43837565
116Primary bile acid biosynthesis_Homo sapiens_hsa001200.43675443
117Ribosome_Homo sapiens_hsa030100.43518546
118MAPK signaling pathway_Homo sapiens_hsa040100.43207729
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43174868
120Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42934590
121Cell cycle_Homo sapiens_hsa041100.42913204
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42713950
123cAMP signaling pathway_Homo sapiens_hsa040240.42565050
124Thyroid hormone synthesis_Homo sapiens_hsa049180.42235580
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.41847047
126Nitrogen metabolism_Homo sapiens_hsa009100.41382443

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