KCTD16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.44868965
2synaptic vesicle exocytosis (GO:0016079)5.24711469
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.20925878
4glutamate secretion (GO:0014047)5.20686853
5vocalization behavior (GO:0071625)5.11243148
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.06816289
7protein localization to synapse (GO:0035418)5.05745062
8sodium ion export (GO:0071436)5.01875812
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.01224029
10neuron cell-cell adhesion (GO:0007158)5.01024858
11neurotransmitter-gated ion channel clustering (GO:0072578)4.96510766
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.80475808
13regulation of glutamate receptor signaling pathway (GO:1900449)4.74240290
14regulation of synaptic vesicle exocytosis (GO:2000300)4.60585991
15neuronal action potential propagation (GO:0019227)4.48578991
16L-amino acid import (GO:0043092)4.37924722
17negative regulation of dendrite morphogenesis (GO:0050774)4.27072411
18positive regulation of synapse maturation (GO:0090129)4.22538023
19synaptic vesicle maturation (GO:0016188)4.18787515
20layer formation in cerebral cortex (GO:0021819)4.18466867
21presynaptic membrane assembly (GO:0097105)4.12383258
22cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.10082776
23regulation of synaptic vesicle transport (GO:1902803)4.07627714
24locomotory exploration behavior (GO:0035641)4.06682259
25neuron-neuron synaptic transmission (GO:0007270)4.01775234
26negative regulation of synaptic transmission, GABAergic (GO:0032229)3.98002550
27positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.94718840
28ionotropic glutamate receptor signaling pathway (GO:0035235)3.93445636
29dendritic spine morphogenesis (GO:0060997)3.87699243
30presynaptic membrane organization (GO:0097090)3.86844552
31synaptic transmission, glutamatergic (GO:0035249)3.85028393
32neurotransmitter secretion (GO:0007269)3.81430138
33membrane depolarization during action potential (GO:0086010)3.75597325
34calcium ion-dependent exocytosis (GO:0017156)3.72353006
35glutamate receptor signaling pathway (GO:0007215)3.69120151
36regulation of excitatory postsynaptic membrane potential (GO:0060079)3.68243862
37negative regulation of dendrite development (GO:2000171)3.66877860
38amino acid import (GO:0043090)3.63817180
39regulation of synaptic transmission, glutamatergic (GO:0051966)3.63582738
40postsynaptic membrane organization (GO:0001941)3.63080706
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.62988244
42urinary tract smooth muscle contraction (GO:0014848)3.60973561
43regulation of neuronal synaptic plasticity (GO:0048168)3.60934392
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.60472929
45regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.59542237
46gamma-aminobutyric acid signaling pathway (GO:0007214)3.59468778
47neuronal ion channel clustering (GO:0045161)3.59249203
48cell communication by electrical coupling (GO:0010644)3.59039376
49cellular sodium ion homeostasis (GO:0006883)3.56911256
50proline transport (GO:0015824)3.55616558
51long-term synaptic potentiation (GO:0060291)3.54566224
52regulation of postsynaptic membrane potential (GO:0060078)3.52796721
53transmission of nerve impulse (GO:0019226)3.52316080
54cerebellar Purkinje cell differentiation (GO:0021702)3.51896825
55potassium ion homeostasis (GO:0055075)3.50662094
56serotonin metabolic process (GO:0042428)3.48673545
57regulation of long-term neuronal synaptic plasticity (GO:0048169)3.48297051
58gamma-aminobutyric acid transport (GO:0015812)3.41912547
59negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.41180229
60long-term memory (GO:0007616)3.40817958
61positive regulation of membrane potential (GO:0045838)3.40743409
62auditory behavior (GO:0031223)3.40451886
63regulation of synaptic plasticity (GO:0048167)3.39726169
64regulation of synapse maturation (GO:0090128)3.39035101
65exploration behavior (GO:0035640)3.38573968
66regulation of voltage-gated calcium channel activity (GO:1901385)3.38217542
67positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.38193207
68positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.37978548
69response to histamine (GO:0034776)3.37438611
70regulation of neurotransmitter levels (GO:0001505)3.36866107
71ATP hydrolysis coupled proton transport (GO:0015991)3.33727456
72energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.33727456
73membrane depolarization (GO:0051899)3.32773544
74behavioral fear response (GO:0001662)3.30542122
75behavioral defense response (GO:0002209)3.30542122
76C4-dicarboxylate transport (GO:0015740)3.30221137
77regulation of neurotransmitter secretion (GO:0046928)3.29931678
78pyrimidine nucleobase catabolic process (GO:0006208)3.29454252
79neuronal action potential (GO:0019228)3.28164159
80potassium ion import (GO:0010107)3.25877798
81synaptic vesicle endocytosis (GO:0048488)3.24882710
82acrosome reaction (GO:0007340)3.22603311
83activation of protein kinase A activity (GO:0034199)3.17383123
84detection of calcium ion (GO:0005513)3.15874588
85behavioral response to cocaine (GO:0048148)3.13944897
86neuron recognition (GO:0008038)3.13169847
87adult walking behavior (GO:0007628)3.12607403
88fear response (GO:0042596)3.12292797
89cerebellar granule cell differentiation (GO:0021707)3.12223327
90neuromuscular process (GO:0050905)3.11216378
91neuromuscular synaptic transmission (GO:0007274)3.11181347
92transferrin transport (GO:0033572)3.09861105
93positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.09830971
94primary amino compound metabolic process (GO:1901160)3.08986430
95positive regulation of dendritic spine morphogenesis (GO:0061003)3.08392827
96positive regulation of neurotransmitter secretion (GO:0001956)3.07948796
97regulation of glutamate secretion (GO:0014048)3.07830558
98regulation of synapse structural plasticity (GO:0051823)3.07676975
99negative regulation of cytosolic calcium ion concentration (GO:0051481)3.07577532
100regulation of dendritic spine development (GO:0060998)3.06914679
101neurotransmitter transport (GO:0006836)3.06525680
102cell migration in hindbrain (GO:0021535)3.05065037
103regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.04545267
104synaptic transmission (GO:0007268)3.03298400
105positive regulation of synaptic transmission, GABAergic (GO:0032230)3.02551420
106neuromuscular process controlling balance (GO:0050885)3.02492002
107cell communication involved in cardiac conduction (GO:0086065)3.01860760
108positive regulation of dendritic spine development (GO:0060999)3.00665391
109establishment of mitochondrion localization (GO:0051654)3.00533140
110acidic amino acid transport (GO:0015800)2.99659224
111central nervous system myelination (GO:0022010)2.96672942
112axon ensheathment in central nervous system (GO:0032291)2.96672942
113positive regulation of potassium ion transmembrane transport (GO:1901381)2.95913347
114regulation of protein kinase A signaling (GO:0010738)2.92643469
115G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.91950475
116regulation of neurotransmitter transport (GO:0051588)2.91267152
117learning (GO:0007612)2.91109250
118cellular potassium ion homeostasis (GO:0030007)2.90464411
119positive regulation of synaptic transmission (GO:0050806)2.90213632
120positive regulation of muscle hypertrophy (GO:0014742)2.90192730
121positive regulation of cardiac muscle hypertrophy (GO:0010613)2.90192730
122G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.88773867
123innervation (GO:0060384)2.88352839
124axonal fasciculation (GO:0007413)2.87980562
125trivalent inorganic cation transport (GO:0072512)2.87106835
126ferric iron transport (GO:0015682)2.87106835
127positive regulation of neurotransmitter transport (GO:0051590)2.86936418
128regulation of synaptic transmission (GO:0050804)2.86814430
129regulation of vesicle fusion (GO:0031338)2.85468446
130regulation of synaptic transmission, GABAergic (GO:0032228)2.84370322
131response to auditory stimulus (GO:0010996)2.84359762
132synapse assembly (GO:0007416)2.82949062
133regulation of dendritic spine morphogenesis (GO:0061001)2.82120671
134startle response (GO:0001964)2.81459817
135positive regulation of synapse assembly (GO:0051965)2.80329836
136mechanosensory behavior (GO:0007638)2.80239938

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.28675295
2* GBX2_23144817_ChIP-Seq_PC3_Human4.23490847
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.93869731
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69360624
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.68987974
6REST_21632747_ChIP-Seq_MESCs_Mouse2.58216914
7TAF15_26573619_Chip-Seq_HEK293_Human2.56510288
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.48827719
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.39730681
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.33991072
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.29868629
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.29509787
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.29509787
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.28927834
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27172020
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24392869
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23681862
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18324447
19* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11438672
20VDR_22108803_ChIP-Seq_LS180_Human2.10467182
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.09925191
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.06188103
23* RARB_27405468_Chip-Seq_BRAIN_Mouse2.03788662
24* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02317463
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.00658116
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99993893
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.92812893
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.91533088
29* SMAD4_21799915_ChIP-Seq_A2780_Human1.89246833
30DROSHA_22980978_ChIP-Seq_HELA_Human1.86262377
31* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85482450
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81554316
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79188746
34* P300_19829295_ChIP-Seq_ESCs_Human1.78973824
35* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70436507
36* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69350571
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65680873
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62815824
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60614801
40* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.58065208
41* CBX2_27304074_Chip-Seq_ESCs_Mouse1.55312849
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52963294
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.50815083
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49477164
45AR_25329375_ChIP-Seq_VCAP_Human1.46646477
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46638296
47RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.43745249
48* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43476029
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42371136
50RNF2_27304074_Chip-Seq_NSC_Mouse1.40827763
51ZNF274_21170338_ChIP-Seq_K562_Hela1.39880990
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.39712230
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37934282
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35322906
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.35197202
56FUS_26573619_Chip-Seq_HEK293_Human1.32290103
57STAT3_23295773_ChIP-Seq_U87_Human1.29593659
58TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.29219173
59* SOX2_21211035_ChIP-Seq_LN229_Gbm1.27287706
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25998269
61AHR_22903824_ChIP-Seq_MCF-7_Human1.25665550
62* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24236207
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23959531
64* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23659494
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23276867
66ARNT_22903824_ChIP-Seq_MCF-7_Human1.22079466
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21704346
68* TCF4_23295773_ChIP-Seq_U87_Human1.19378039
69KDM2B_26808549_Chip-Seq_REH_Human1.18495876
70MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14933801
71WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12449005
72IGF1R_20145208_ChIP-Seq_DFB_Human1.11524298
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11182911
74RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10959873
75ER_23166858_ChIP-Seq_MCF-7_Human1.10177208
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.10116244
77JUN_21703547_ChIP-Seq_K562_Human1.10014534
78LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09060679
79AR_21572438_ChIP-Seq_LNCaP_Human1.09036691
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08862988
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06841649
82RUNX2_22187159_ChIP-Seq_PCA_Human1.06780949
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.06067314
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06049960
85AR_19668381_ChIP-Seq_PC3_Human1.05691601
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05666456
87RING1B_27294783_Chip-Seq_NPCs_Mouse1.04911867
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04804690
89GATA1_26923725_Chip-Seq_HPCs_Mouse1.04458507
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04240779
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04240779
92EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02629557
93P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02304080
94BCAT_22108803_ChIP-Seq_LS180_Human1.01049012
95YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99990262
96SOX9_26525672_Chip-Seq_HEART_Mouse0.99261447
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99094682
98SMAD3_21741376_ChIP-Seq_ESCs_Human0.99022378
99* RING1B_27294783_Chip-Seq_ESCs_Mouse0.97907294
100CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97675315
101ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97155319
102ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96929057
103TP53_16413492_ChIP-PET_HCT116_Human0.96661902
104FLI1_27457419_Chip-Seq_LIVER_Mouse0.96415364
105KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96126715
106CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95569556
107ERG_21242973_ChIP-ChIP_JURKAT_Human0.94173939
108IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93681166
109CBP_20019798_ChIP-Seq_JUKART_Human0.93681166
110FLI1_21867929_ChIP-Seq_TH2_Mouse0.93186930
111NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92905499
112STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92470591
113* TP53_18474530_ChIP-ChIP_U2OS_Human0.91030044

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.38256704
2MP0003880_abnormal_central_pattern4.85536167
3MP0001968_abnormal_touch/_nociception4.15243598
4MP0002735_abnormal_chemical_nociception4.03772421
5MP0003635_abnormal_synaptic_transmissio3.72719269
6MP0002736_abnormal_nociception_after3.62727275
7MP0004270_analgesia3.55709486
8MP0009745_abnormal_behavioral_response3.28978810
9MP0009046_muscle_twitch3.27599461
10MP0002822_catalepsy3.24310957
11MP0002063_abnormal_learning/memory/cond3.09751774
12MP0002064_seizures3.07035922
13MP0002734_abnormal_mechanical_nocicepti2.87739854
14MP0002572_abnormal_emotion/affect_behav2.74768578
15MP0002272_abnormal_nervous_system2.69602258
16MP0001984_abnormal_olfaction2.48215021
17MP0002733_abnormal_thermal_nociception2.30513640
18MP0006276_abnormal_autonomic_nervous2.30396253
19MP0001486_abnormal_startle_reflex2.22636357
20MP0001970_abnormal_pain_threshold2.21575469
21MP0002067_abnormal_sensory_capabilities2.16918554
22MP0005410_abnormal_fertilization2.13074721
23MP0001501_abnormal_sleep_pattern2.03994056
24MP0002184_abnormal_innervation1.96203434
25MP0003879_abnormal_hair_cell1.92665933
26MP0004858_abnormal_nervous_system1.89846157
27MP0001440_abnormal_grooming_behavior1.89836960
28MP0005423_abnormal_somatic_nervous1.76528426
29MP0005646_abnormal_pituitary_gland1.74625945
30MP0001986_abnormal_taste_sensitivity1.67339577
31MP0002557_abnormal_social/conspecific_i1.66030548
32MP0009780_abnormal_chondrocyte_physiolo1.65676153
33MP0004811_abnormal_neuron_physiology1.63543127
34MP0000778_abnormal_nervous_system1.58063209
35MP0004924_abnormal_behavior1.55163871
36MP0005386_behavior/neurological_phenoty1.55163871
37MP0003329_amyloid_beta_deposits1.52354467
38MP0003787_abnormal_imprinting1.51545208
39MP0008569_lethality_at_weaning1.50647295
40MP0002837_dystrophic_cardiac_calcinosis1.45565548
41MP0001529_abnormal_vocalization1.44734482
42MP0000955_abnormal_spinal_cord1.33922735
43MP0002882_abnormal_neuron_morphology1.33174757
44MP0002066_abnormal_motor_capabilities/c1.24847240
45MP0002638_abnormal_pupillary_reflex1.24493977
46MP0001188_hyperpigmentation1.23894043
47MP0010386_abnormal_urinary_bladder1.23166915
48MP0002876_abnormal_thyroid_physiology1.20894756
49MP0001905_abnormal_dopamine_level1.20409699
50MP0005645_abnormal_hypothalamus_physiol1.16636602
51MP0003690_abnormal_glial_cell1.15053101
52MP0001502_abnormal_circadian_rhythm1.11259765
53MP0003633_abnormal_nervous_system1.10406381
54MP0002909_abnormal_adrenal_gland1.10145262
55MP0004142_abnormal_muscle_tone1.05205153
56MP0005394_taste/olfaction_phenotype1.01579061
57MP0005499_abnormal_olfactory_system1.01579061
58MP0003122_maternal_imprinting1.00054382
59MP0001963_abnormal_hearing_physiology0.99734109
60MP0001348_abnormal_lacrimal_gland0.97274484
61MP0000920_abnormal_myelination0.96603785
62MP0004085_abnormal_heartbeat0.96576072
63MP0002229_neurodegeneration0.95758226
64MP0000751_myopathy0.94998290
65MP0003698_abnormal_male_reproductive0.94473745
66MP0003631_nervous_system_phenotype0.93240623
67MP0002653_abnormal_ependyma_morphology0.93010788
68MP0008872_abnormal_physiological_respon0.92942172
69MP0004742_abnormal_vestibular_system0.91710059
70MP0004147_increased_porphyrin_level0.90494350
71MP0005551_abnormal_eye_electrophysiolog0.89324241
72MP0002152_abnormal_brain_morphology0.89300943
73MP0004885_abnormal_endolymph0.83600351
74MP0008874_decreased_physiological_sensi0.82627771
75MP0002752_abnormal_somatic_nervous0.81696146
76MP0008877_abnormal_DNA_methylation0.80683698
77MP0002069_abnormal_eating/drinking_beha0.78724746
78MP0004133_heterotaxia0.77723676
79MP0003183_abnormal_peptide_metabolism0.74831688
80MP0005187_abnormal_penis_morphology0.72556452
81MP0002751_abnormal_autonomic_nervous0.71489420
82MP0004215_abnormal_myocardial_fiber0.71422907
83MP0004484_altered_response_of0.70941772
84MP0003121_genomic_imprinting0.70429552
85MP0005409_darkened_coat_color0.69648609
86MP0004145_abnormal_muscle_electrophysio0.69144291
87MP0005171_absent_coat_pigmentation0.68416456
88MP0004233_abnormal_muscle_weight0.68171781
89MP0001299_abnormal_eye_distance/0.68119123
90MP0001664_abnormal_digestion0.66955990
91MP0000604_amyloidosis0.66374614
92MP0005623_abnormal_meninges_morphology0.65455295
93MP0000569_abnormal_digit_pigmentation0.65443855
94MP0008260_abnormal_autophagy0.65201054
95MP0003646_muscle_fatigue0.64906163
96MP0001485_abnormal_pinna_reflex0.64867903
97MP0005535_abnormal_body_temperature0.64419299
98MP0004036_abnormal_muscle_relaxation0.64370630
99MP0004130_abnormal_muscle_cell0.63308565
100MP0003861_abnormal_nervous_system0.61323690
101MP0000026_abnormal_inner_ear0.60825798
102MP0003634_abnormal_glial_cell0.60488064
103MP0002082_postnatal_lethality0.57967596
104MP0010770_preweaning_lethality0.57967596
105MP0000013_abnormal_adipose_tissue0.57951241
106MP0000631_abnormal_neuroendocrine_gland0.57880563
107MP0010769_abnormal_survival0.56887857
108MP0008789_abnormal_olfactory_epithelium0.55626181
109MP0003283_abnormal_digestive_organ0.54151104
110MP0010768_mortality/aging0.53658390
111MP0002160_abnormal_reproductive_system0.53446654
112MP0004043_abnormal_pH_regulation0.53060185
113MP0000534_abnormal_ureter_morphology0.52259114
114MP0002090_abnormal_vision0.51771583
115MP0001943_abnormal_respiration0.51223543
116MP0003632_abnormal_nervous_system0.50467744
117MP0001177_atelectasis0.49642360
118MP0003137_abnormal_impulse_conducting0.48462898
119MP0002081_perinatal_lethality0.48164275
120MP0005253_abnormal_eye_physiology0.48004673
121MP0002161_abnormal_fertility/fecundity0.46999445
122MP0001929_abnormal_gametogenesis0.45415201

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.23309665
2Atonic seizures (HP:0010819)6.09474021
3Myokymia (HP:0002411)6.04145572
4Focal seizures (HP:0007359)5.76190000
5Epileptic encephalopathy (HP:0200134)5.63100222
6Febrile seizures (HP:0002373)5.46972425
7Hyperventilation (HP:0002883)5.38386765
8Absence seizures (HP:0002121)4.74327934
9Dialeptic seizures (HP:0011146)4.38921477
10Visual hallucinations (HP:0002367)4.05138603
11Progressive cerebellar ataxia (HP:0002073)3.85405186
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.78128634
13Absent/shortened dynein arms (HP:0200106)3.78128634
14Diplopia (HP:0000651)3.72794351
15Abnormality of binocular vision (HP:0011514)3.72794351
16Generalized tonic-clonic seizures (HP:0002069)3.71983663
17Broad-based gait (HP:0002136)3.33164785
18Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.25286293
19Gaze-evoked nystagmus (HP:0000640)3.23888193
20Genetic anticipation (HP:0003743)3.14289704
21Impaired vibration sensation in the lower limbs (HP:0002166)3.11954218
22Hemiparesis (HP:0001269)3.10466825
23Truncal ataxia (HP:0002078)3.08681102
24Gait imbalance (HP:0002141)2.99638999
25Inability to walk (HP:0002540)2.98973821
26Mutism (HP:0002300)2.89348080
27Amblyopia (HP:0000646)2.88320795
28Poor eye contact (HP:0000817)2.83321636
29Medial flaring of the eyebrow (HP:0010747)2.79943563
30Amyotrophic lateral sclerosis (HP:0007354)2.79179825
31Termporal pattern (HP:0011008)2.76567722
32Insidious onset (HP:0003587)2.76567722
33Action tremor (HP:0002345)2.76428440
34Dysdiadochokinesis (HP:0002075)2.76391083
35Congenital primary aphakia (HP:0007707)2.76075275
36Abnormal respiratory epithelium morphology (HP:0012253)2.75928928
37Abnormal respiratory motile cilium morphology (HP:0005938)2.75928928
38Hemiplegia (HP:0002301)2.73298606
39Abnormal respiratory motile cilium physiology (HP:0012261)2.71810495
40Pheochromocytoma (HP:0002666)2.67996292
41Progressive inability to walk (HP:0002505)2.65669923
42Epileptiform EEG discharges (HP:0011182)2.64682910
43Nephrogenic diabetes insipidus (HP:0009806)2.63107280
44Papilledema (HP:0001085)2.61896143
45Abnormal eating behavior (HP:0100738)2.60070644
46Ankle clonus (HP:0011448)2.57169295
47Abnormal ciliary motility (HP:0012262)2.56213620
48Impaired social interactions (HP:0000735)2.53121648
49Abnormal social behavior (HP:0012433)2.53121648
50Urinary bladder sphincter dysfunction (HP:0002839)2.50185083
51Dysmetric saccades (HP:0000641)2.47536418
52Neurofibrillary tangles (HP:0002185)2.46236372
53Abnormal hair whorl (HP:0010721)2.42995399
54Hypothermia (HP:0002045)2.42777728
55Protruding tongue (HP:0010808)2.42396635
56Scanning speech (HP:0002168)2.38567690
57EEG with generalized epileptiform discharges (HP:0011198)2.37785579
58Neuroendocrine neoplasm (HP:0100634)2.37049785
59Excessive salivation (HP:0003781)2.34509329
60Drooling (HP:0002307)2.34509329
61Depression (HP:0000716)2.33516997
62Genital tract atresia (HP:0001827)2.33378531
63Dysmetria (HP:0001310)2.29796552
64Absent speech (HP:0001344)2.27929547
65Impaired smooth pursuit (HP:0007772)2.26296155
66Vaginal atresia (HP:0000148)2.24295195
67Urinary urgency (HP:0000012)2.23683279
68Polyphagia (HP:0002591)2.23618309
69Specific learning disability (HP:0001328)2.22698016
70Intention tremor (HP:0002080)2.22649255
71Abnormality of pain sensation (HP:0010832)2.22596300
72Impaired pain sensation (HP:0007328)2.22596300
73Postural tremor (HP:0002174)2.20974414
74Impaired vibratory sensation (HP:0002495)2.20618161
75Abnormality of the lower motor neuron (HP:0002366)2.18328406
76Poor coordination (HP:0002370)2.12192958
77Sensory axonal neuropathy (HP:0003390)2.12046313
78Hypsarrhythmia (HP:0002521)2.11598745
79Spastic gait (HP:0002064)2.09696612
80Abnormality of the corticospinal tract (HP:0002492)2.08889514
81Blue irides (HP:0000635)2.07646924
82Anxiety (HP:0000739)2.06714800
83Rhinitis (HP:0012384)2.06634734
84Fetal akinesia sequence (HP:0001989)2.06046078
85Bradycardia (HP:0001662)2.05764546
86Supranuclear gaze palsy (HP:0000605)2.03862126
87Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.03508821
88Sleep apnea (HP:0010535)2.00610700
89Clonus (HP:0002169)1.97462479
90Morphological abnormality of the pyramidal tract (HP:0002062)1.97072437
91Gait ataxia (HP:0002066)1.95141068
92Torticollis (HP:0000473)1.93667567
93Status epilepticus (HP:0002133)1.91971185
94Poor suck (HP:0002033)1.91895788
95Akinesia (HP:0002304)1.91782514
96Lower limb muscle weakness (HP:0007340)1.91478235
97Ulnar claw (HP:0001178)1.90404076
98Limb dystonia (HP:0002451)1.90039048
99Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.89802647
100Degeneration of the lateral corticospinal tracts (HP:0002314)1.89802647
101Focal dystonia (HP:0004373)1.89409216
102Spastic tetraplegia (HP:0002510)1.86818606
103Cerebral inclusion bodies (HP:0100314)1.86752038
104Acute necrotizing encephalopathy (HP:0006965)1.86165916
105Craniofacial dystonia (HP:0012179)1.85820861
106Chronic hepatic failure (HP:0100626)1.85031349
107Abnormality of the labia minora (HP:0012880)1.84596941
108Abnormality of ocular smooth pursuit (HP:0000617)1.84117984
109Infertility (HP:0000789)1.83622698
110Failure to thrive in infancy (HP:0001531)1.82950139
111Stereotypic behavior (HP:0000733)1.82516639
112Cholecystitis (HP:0001082)1.81540664
113Abnormal gallbladder physiology (HP:0012438)1.81540664
114Neuronal loss in central nervous system (HP:0002529)1.80328417
115Abnormality of midbrain morphology (HP:0002418)1.79907625
116Molar tooth sign on MRI (HP:0002419)1.79907625
117Bradykinesia (HP:0002067)1.77820960
118Hypoplasia of the brainstem (HP:0002365)1.77803793
119Aplasia/Hypoplasia of the brainstem (HP:0007362)1.77803793
120Megalencephaly (HP:0001355)1.76443999
121Obstructive sleep apnea (HP:0002870)1.76026859
122Generalized myoclonic seizures (HP:0002123)1.75631623
123Progressive macrocephaly (HP:0004481)1.75477950
124Abnormality of salivation (HP:0100755)1.75302733
125Agitation (HP:0000713)1.75265267
126Nephronophthisis (HP:0000090)1.74911169
127Hyperthyroidism (HP:0000836)1.74570795
128Incomplete penetrance (HP:0003829)1.73949603
129Postural instability (HP:0002172)1.73076697
130Split foot (HP:0001839)1.72544690
131Syncope (HP:0001279)1.71770985
132Esotropia (HP:0000565)1.71512737
133Delusions (HP:0000746)1.71426814
134Prolonged QT interval (HP:0001657)1.69271482
135Hypoplasia of the corpus callosum (HP:0002079)1.65549629

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.16097377
2NTRK33.95955309
3EPHA43.73692441
4MAP3K93.11533584
5MAP2K73.05831955
6MAP3K43.02626766
7DAPK22.90977939
8MINK12.40346548
9DAPK12.13373122
10AKT32.02636481
11MAP3K121.99588409
12PLK21.98920152
13CCNB11.97129871
14PRPF4B1.94641975
15MARK11.76481250
16RIPK41.76449460
17MAP2K41.74331932
18NTRK21.73970991
19SIK31.72901746
20ARAF1.72374000
21PAK61.72065520
22PDK31.63491889
23PDK41.63491889
24TNIK1.55353433
25NTRK11.52111734
26CDK191.47098057
27GRK51.47003317
28PTK2B1.41855980
29SGK4941.39460046
30SGK2231.39460046
31KSR21.37610013
32FRK1.36640556
33KSR11.31750558
34SGK21.31490170
35CDK51.31335565
36PRKD31.30387510
37MAPK131.28055197
38PRKCG1.25814237
39CAMKK21.23890694
40CAMKK11.10682532
41BRAF1.06508558
42CAMK2A1.02018496
43CDK180.90831356
44PHKG20.90792438
45PHKG10.90792438
46CAMK2B0.87797098
47OXSR10.87348283
48CDK140.85513961
49PDK20.84855816
50FER0.82695681
51FES0.82389131
52SGK30.82034399
53CDK150.79306852
54BMPR20.78624630
55PNCK0.78043336
56PKN10.77054147
57STK380.76350208
58BCR0.76027296
59TYRO30.74884060
60PRKCE0.74404380
61CSNK1A1L0.73188766
62DYRK20.71968306
63CAMK10.70609064
64MAP3K130.69672977
65CDK11A0.67141796
66MUSK0.66931159
67LIMK10.64756134
68NME10.64252146
69TESK10.63190490
70PDK10.62399833
71CAMK2D0.61128423
72LMTK20.59464358
73TSSK60.58592451
74ADRBK20.58146032
75RPS6KA30.57542077
76CSNK1G30.57352506
77UHMK10.56908025
78MAP2K10.55437830
79TNK20.54593821
80SIK20.52111077
81DAPK30.50783882
82MARK20.49241020
83DYRK1A0.49228390
84RAF10.47965428
85LATS20.47960133
86MAP3K20.47941595
87MAPK100.47699625
88PDPK10.47667234
89CDK30.47363973
90SGK10.47139596
91INSRR0.46170983
92PRKCH0.45675362
93WNK30.44791427
94CSNK1D0.43908028
95ADRBK10.43196024
96PRKG10.42415639
97RPS6KA20.41503824
98MAPK70.40812793
99PINK10.39985854
100FYN0.39791905
101CAMK2G0.39375954
102PRKCA0.39372078
103RET0.38561825
104CSNK1G10.38268045
105CDK80.38163580
106PRKCZ0.37037942
107MAPK120.36871607
108FGR0.36633545
109PRKACA0.36547653
110WNK40.34134007
111MAP3K10.33740616
112WNK10.33245400
113PAK30.32876018
114NEK10.32232478
115CSNK1A10.32114167
116TAOK10.31734612
117STK390.31634643
118PRKCB0.31453878
119CAMK40.31177755
120STK110.31100135
121MAPKAPK50.30910220
122CSNK1G20.30858779
123EPHB20.29112029
124ERBB20.28207071
125PRKACB0.28068040
126CSNK1E0.27688591

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.91930528
2Nicotine addiction_Homo sapiens_hsa050333.71032641
3Olfactory transduction_Homo sapiens_hsa047403.09928336
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.82264651
5Collecting duct acid secretion_Homo sapiens_hsa049662.75711525
6Circadian entrainment_Homo sapiens_hsa047132.70266451
7Long-term potentiation_Homo sapiens_hsa047202.57923556
8GABAergic synapse_Homo sapiens_hsa047272.56537306
9Morphine addiction_Homo sapiens_hsa050322.55631750
10Amphetamine addiction_Homo sapiens_hsa050312.32921759
11Glutamatergic synapse_Homo sapiens_hsa047242.32697690
12Taste transduction_Homo sapiens_hsa047422.22135313
13Salivary secretion_Homo sapiens_hsa049702.17236563
14Dopaminergic synapse_Homo sapiens_hsa047282.14045260
15Insulin secretion_Homo sapiens_hsa049112.12363029
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.12055721
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.77882633
18Cholinergic synapse_Homo sapiens_hsa047251.75523701
19Serotonergic synapse_Homo sapiens_hsa047261.73375784
20Vibrio cholerae infection_Homo sapiens_hsa051101.61794757
21Renin secretion_Homo sapiens_hsa049241.61278935
22Calcium signaling pathway_Homo sapiens_hsa040201.60577283
23Gastric acid secretion_Homo sapiens_hsa049711.58715047
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53951165
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53781213
26Long-term depression_Homo sapiens_hsa047301.50456568
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49779184
28Oxytocin signaling pathway_Homo sapiens_hsa049211.48536543
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35918543
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34546720
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.32015295
32Oxidative phosphorylation_Homo sapiens_hsa001901.26239615
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24412595
34Cardiac muscle contraction_Homo sapiens_hsa042601.23797766
35Cocaine addiction_Homo sapiens_hsa050301.21572478
36Phototransduction_Homo sapiens_hsa047441.17928972
37Gap junction_Homo sapiens_hsa045401.15338559
38GnRH signaling pathway_Homo sapiens_hsa049121.13502168
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10540822
40cAMP signaling pathway_Homo sapiens_hsa040241.08523447
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05832673
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03228646
43Estrogen signaling pathway_Homo sapiens_hsa049151.02472658
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96849493
45Axon guidance_Homo sapiens_hsa043600.94836622
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94276736
47Alzheimers disease_Homo sapiens_hsa050100.91050803
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.90806015
49ErbB signaling pathway_Homo sapiens_hsa040120.90150907
50Glioma_Homo sapiens_hsa052140.89959753
51Melanogenesis_Homo sapiens_hsa049160.87767720
52Oocyte meiosis_Homo sapiens_hsa041140.86795804
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78963881
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78701491
55Pancreatic secretion_Homo sapiens_hsa049720.77377630
56Type II diabetes mellitus_Homo sapiens_hsa049300.77309052
57Parkinsons disease_Homo sapiens_hsa050120.76118609
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75792828
59Glucagon signaling pathway_Homo sapiens_hsa049220.72938087
60Thyroid hormone synthesis_Homo sapiens_hsa049180.69398268
61Pyruvate metabolism_Homo sapiens_hsa006200.68351549
62Vitamin B6 metabolism_Homo sapiens_hsa007500.68064807
63Rheumatoid arthritis_Homo sapiens_hsa053230.67477717
64MAPK signaling pathway_Homo sapiens_hsa040100.60934973
65Dilated cardiomyopathy_Homo sapiens_hsa054140.59749981
66Huntingtons disease_Homo sapiens_hsa050160.58932579
67Alcoholism_Homo sapiens_hsa050340.57420426
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56275444
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.54732761
70Type I diabetes mellitus_Homo sapiens_hsa049400.51980785
71Ras signaling pathway_Homo sapiens_hsa040140.51379250
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50736149
73Choline metabolism in cancer_Homo sapiens_hsa052310.50360070
74Regulation of autophagy_Homo sapiens_hsa041400.50055581
75Phagosome_Homo sapiens_hsa041450.49761987
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48335835
77Rap1 signaling pathway_Homo sapiens_hsa040150.46297382
78Dorso-ventral axis formation_Homo sapiens_hsa043200.45854748
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43178605
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.42384911
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42373378
82Prion diseases_Homo sapiens_hsa050200.39631096
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36944215
84VEGF signaling pathway_Homo sapiens_hsa043700.36883060
85Circadian rhythm_Homo sapiens_hsa047100.35726059
86Hippo signaling pathway_Homo sapiens_hsa043900.35285754
87Insulin signaling pathway_Homo sapiens_hsa049100.34087576
88Inositol phosphate metabolism_Homo sapiens_hsa005620.34073975
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.33508297
90Mineral absorption_Homo sapiens_hsa049780.33478493
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33380647
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.33222002
93Melanoma_Homo sapiens_hsa052180.33089368
94Bile secretion_Homo sapiens_hsa049760.32424260
95Butanoate metabolism_Homo sapiens_hsa006500.32231662
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30594650
97Selenocompound metabolism_Homo sapiens_hsa004500.28584503
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28492264
99Fatty acid biosynthesis_Homo sapiens_hsa000610.28226612
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27931111
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27900127
102Protein digestion and absorption_Homo sapiens_hsa049740.27272567
103Ovarian steroidogenesis_Homo sapiens_hsa049130.27035793
104Endometrial cancer_Homo sapiens_hsa052130.26862551
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26566431
106Endocytosis_Homo sapiens_hsa041440.26484360
107Glycerolipid metabolism_Homo sapiens_hsa005610.26318366
108Wnt signaling pathway_Homo sapiens_hsa043100.25545197
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25453708
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25328232
111African trypanosomiasis_Homo sapiens_hsa051430.24539560
112Tight junction_Homo sapiens_hsa045300.23506938
113mTOR signaling pathway_Homo sapiens_hsa041500.22736956
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22632472
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22488560
116Nitrogen metabolism_Homo sapiens_hsa009100.21478344
117Ether lipid metabolism_Homo sapiens_hsa005650.20670393
118beta-Alanine metabolism_Homo sapiens_hsa004100.20496463
119Histidine metabolism_Homo sapiens_hsa003400.19457380

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