ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	L-phenylalanine catabolic process (GO:0006559)	4.02342365
2	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	4.02342365
3	L-phenylalanine metabolic process (GO:0006558)	3.70652480
4	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.70652480
5	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.64563358
6	fatty acid homeostasis (GO:0055089)	3.63304045
7	phosphatidylethanolamine metabolic process (GO:0046337)	3.40337777
8	negative regulation of cholesterol transport (GO:0032375)	3.34980414
9	negative regulation of sterol transport (GO:0032372)	3.34980414
10	drug catabolic process (GO:0042737)	3.29235152
11	bile acid biosynthetic process (GO:0006699)	3.25902561
12	carnitine shuttle (GO:0006853)	3.23047037
13	alpha-linolenic acid metabolic process (GO:0036109)	3.20749632
14	ncRNA 3-end processing (GO:0043628)	3.14099529
15	fatty acid transmembrane transport (GO:1902001)	3.13691802
16	aromatic amino acid family catabolic process (GO:0009074)	3.05631598
17	positive regulation of glycolytic process (GO:0045821)	3.02794547
18	regulation of G0 to G1 transition (GO:0070316)	2.98467443
19	protein carboxylation (GO:0018214)	2.94230409
20	peptidyl-glutamic acid carboxylation (GO:0017187)	2.94230409
21	glyoxylate metabolic process (GO:0046487)	2.90636420
22	negative regulation of cAMP-mediated signaling (GO:0043951)	2.81456288
23	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.79739222
24	sulfur amino acid catabolic process (GO:0000098)	2.78665720
25	negative regulation of heart rate (GO:0010459)	2.76897789
26	bile acid metabolic process (GO:0008206)	2.73140346
27	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.72103057
28	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.71593847
29	negative regulation of T-helper cell differentiation (GO:0045623)	2.70813214
30	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.70813214
31	regulation of cholesterol biosynthetic process (GO:0045540)	2.68633826
32	glycine transport (GO:0015816)	2.67957418
33	synaptic vesicle maturation (GO:0016188)	2.64830536
34	regulation of energy homeostasis (GO:2000505)	2.62188624
35	glutamate secretion (GO:0014047)	2.61960249
36	inositol phosphate dephosphorylation (GO:0046855)	2.61011958
37	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.61011958
38	flavonoid metabolic process (GO:0009812)	2.60990178
39	gamma-aminobutyric acid transport (GO:0015812)	2.58128621
40	complement activation, alternative pathway (GO:0006957)	2.57618518
41	synaptic vesicle exocytosis (GO:0016079)	2.56422702
42	regulation of T-helper 2 cell differentiation (GO:0045628)	2.56113930
43	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	2.55529251
44	response to muscle activity (GO:0014850)	2.53164763
45	inositol phosphate catabolic process (GO:0071545)	2.53001127
46	cellular ketone body metabolic process (GO:0046950)	2.52583709
47	negative regulation of lipid catabolic process (GO:0050995)	2.51293403
48	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	2.51248767
49	detection of molecule of bacterial origin (GO:0032490)	2.51086994
50	high-density lipoprotein particle remodeling (GO:0034375)	2.49518823
51	negative regulation of cell killing (GO:0031342)	2.46123966
52	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	2.46123966
53	cysteine metabolic process (GO:0006534)	2.45952583
54	negative regulation of lipase activity (GO:0060192)	2.45794056
55	glutamate metabolic process (GO:0006536)	2.44259578
56	regulation of interferon-beta biosynthetic process (GO:0045357)	2.43550213
57	multicellular organism reproduction (GO:0032504)	2.43387151
58	omega-hydroxylase P450 pathway (GO:0097267)	2.42677820
59	regulation of synapse structural plasticity (GO:0051823)	2.42011308
60	exogenous drug catabolic process (GO:0042738)	2.41443562
61	positive regulation by symbiont of host defense response (GO:0052509)	2.40909039
62	modulation by symbiont of host defense response (GO:0052031)	2.40909039
63	modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00	2.40909039
64	modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0	2.40909039
65	positive regulation by organism of defense response of other organism involved in symbiotic interact	2.40909039
66	modulation by symbiont of host immune response (GO:0052553)	2.40909039
67	postsynaptic membrane organization (GO:0001941)	2.39572223
68	carnitine transmembrane transport (GO:1902603)	2.39163691
69	synaptic vesicle docking involved in exocytosis (GO:0016081)	2.37037193
70	drug metabolic process (GO:0017144)	2.36767434
71	regulation of triglyceride biosynthetic process (GO:0010866)	2.35599455
72	negative regulation of interleukin-1 production (GO:0032692)	2.34324919
73	tryptophan catabolic process (GO:0006569)	2.32274583
74	indole-containing compound catabolic process (GO:0042436)	2.32274583
75	indolalkylamine catabolic process (GO:0046218)	2.32274583
76	coenzyme catabolic process (GO:0009109)	2.31765252
77	intracellular lipid transport (GO:0032365)	2.31466566
78	positive regulation of triglyceride biosynthetic process (GO:0010867)	2.30890463
79	regulation of cholesterol esterification (GO:0010872)	2.30791382
80	fatty-acyl-CoA biosynthetic process (GO:0046949)	2.30220819
81	regulation of protein activation cascade (GO:2000257)	2.30082993
82	negative regulation of appetite (GO:0032099)	2.29519979
83	negative regulation of response to food (GO:0032096)	2.29519979
84	fatty acid elongation (GO:0030497)	2.28557864
85	plasma lipoprotein particle clearance (GO:0034381)	2.28407532
86	neurotransmitter secretion (GO:0007269)	2.28364390
87	glycosylceramide metabolic process (GO:0006677)	2.28116251
88	kynurenine metabolic process (GO:0070189)	2.27863151
89	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	2.27794343
90	fibrinolysis (GO:0042730)	2.27790974
91	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.27470836
92	reverse cholesterol transport (GO:0043691)	2.27341884
93	urea cycle (GO:0000050)	2.27138804
94	urea metabolic process (GO:0019627)	2.27138804
95	regulation of triglyceride metabolic process (GO:0090207)	2.26362667
96	tryptophan metabolic process (GO:0006568)	2.26348506
97	cholesterol efflux (GO:0033344)	2.25961466
98	L-amino acid import (GO:0043092)	2.25775084
99	amino-acid betaine transport (GO:0015838)	2.25423762
100	carnitine transport (GO:0015879)	2.25423762
101	vocalization behavior (GO:0071625)	2.25258950
102	purine nucleotide transport (GO:0015865)	2.25257436
103	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.25105778
104	positive regulation of humoral immune response (GO:0002922)	2.25030159
105	very long-chain fatty acid metabolic process (GO:0000038)	2.24720044
106	response to dietary excess (GO:0002021)	2.24470205
107	cellular glucuronidation (GO:0052695)	2.24430248
108	dicarboxylic acid biosynthetic process (GO:0043650)	2.24346211
109	regulation of synaptic vesicle exocytosis (GO:2000300)	2.23452119
110	melanin biosynthetic process (GO:0042438)	2.23114473
111	phosphatidylglycerol biosynthetic process (GO:0006655)	2.22544288
112	protein-lipid complex remodeling (GO:0034368)	2.22505750
113	macromolecular complex remodeling (GO:0034367)	2.22505750
114	plasma lipoprotein particle remodeling (GO:0034369)	2.22505750
115	protein import into peroxisome matrix (GO:0016558)	2.22304579
116	microglial cell activation (GO:0001774)	2.21636362
117	macroautophagy (GO:0016236)	2.21375913
118	cofactor catabolic process (GO:0051187)	2.21249922
119	short-chain fatty acid metabolic process (GO:0046459)	2.21091534
120	positive regulation of triglyceride metabolic process (GO:0090208)	2.20586129
121	macrophage activation involved in immune response (GO:0002281)	2.20190971
122	xenobiotic catabolic process (GO:0042178)	2.20021322
123	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	2.19907460
124	regulation of fibrinolysis (GO:0051917)	2.19899922
125	phospholipid homeostasis (GO:0055091)	2.19724117
126	relaxation of smooth muscle (GO:0044557)	2.19658895
127	regulation of complement activation (GO:0030449)	2.19319185
128	type I interferon signaling pathway (GO:0060337)	2.19114199
129	cellular response to type I interferon (GO:0071357)	2.19114199
130	negative regulation of interleukin-1 beta production (GO:0032691)	2.18205132
131	uronic acid metabolic process (GO:0006063)	2.18186790
132	glucuronate metabolic process (GO:0019585)	2.18186790
133	cellular modified amino acid catabolic process (GO:0042219)	2.18034388
134	low-density lipoprotein particle remodeling (GO:0034374)	2.17607667
135	negative regulation of Rho protein signal transduction (GO:0035024)	2.17588293
136	response to type I interferon (GO:0034340)	2.17566080
137	pyrimidine-containing compound salvage (GO:0008655)	2.16926042
138	pyrimidine nucleoside salvage (GO:0043097)	2.16926042
139	regulation of triglyceride catabolic process (GO:0010896)	2.16892618
140	neutrophil mediated immunity (GO:0002446)	2.16665547
141	phosphatidylcholine biosynthetic process (GO:0006656)	2.16336823
142	regulation of cytokine secretion involved in immune response (GO:0002739)	2.15858923
143	negative regulation of fibrinolysis (GO:0051918)	2.15665891
144	positive regulation of macrophage derived foam cell differentiation (GO:0010744)	2.15562452
145	cholesterol homeostasis (GO:0042632)	2.14106140
146	pyrimidine nucleobase catabolic process (GO:0006208)	2.13315503
147	phospholipid efflux (GO:0033700)	2.13013862
148	nitrogen cycle metabolic process (GO:0071941)	2.12972844
149	thioester biosynthetic process (GO:0035384)	2.12899933
150	acyl-CoA biosynthetic process (GO:0071616)	2.12899933
151	ketone body metabolic process (GO:1902224)	2.12276865
152	polyol catabolic process (GO:0046174)	2.11785540
153	fatty-acyl-CoA metabolic process (GO:0035337)	2.11254066
154	sterol homeostasis (GO:0055092)	2.10769388
155	acylglycerol homeostasis (GO:0055090)	2.10607495
156	triglyceride homeostasis (GO:0070328)	2.10607495
157	succinate metabolic process (GO:0006105)	2.10600914
158	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.10570768
159	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	2.10461002
160	cellular extravasation (GO:0045123)	2.09205771
161	acute inflammatory response (GO:0002526)	2.09010062
162	NADH metabolic process (GO:0006734)	2.08219539
163	pyrimidine dimer repair (GO:0006290)	2.07833067
164	negative regulation of Ras GTPase activity (GO:0034261)	2.07440102
165	regulation of sensory perception of pain (GO:0051930)	2.05240506
166	regulation of sensory perception (GO:0051931)	2.05240506
167	regulation of acrosome reaction (GO:0060046)	2.05140758
168	negative regulation of protein activation cascade (GO:2000258)	2.04701931
169	negative regulation of smooth muscle contraction (GO:0045986)	2.04101113
170	positive regulation of coagulation (GO:0050820)	2.03112548
171	positive regulation of hemostasis (GO:1900048)	2.02402172
172	positive regulation of blood coagulation (GO:0030194)	2.02402172
173	primary alcohol catabolic process (GO:0034310)	2.01294026
174	regulation of interleukin-12 biosynthetic process (GO:0045075)	2.00907573
175	membrane tubulation (GO:0097320)	2.00578702
176	activated T cell proliferation (GO:0050798)	1.99914025

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	4.14084335
2	RXR_22158963_ChIP-Seq_LIVER_Mouse	3.01074070
3	* LXR_22158963_ChIP-Seq_LIVER_Mouse	2.77100845
4	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	2.56207359
5	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.53188304
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.50612256
7	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.47170369
8	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.95936403
9	EZH2_22144423_ChIP-Seq_EOC_Human	1.91228165
10	AR_21572438_ChIP-Seq_LNCaP_Human	1.85691170
11	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.82634952
12	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.80317458
13	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.73568721
14	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.73093653
15	* MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.70509819
16	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.67919369
17	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.65848965
18	DROSHA_22980978_ChIP-Seq_HELA_Human	1.62450883
19	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.61549334
20	IGF1R_20145208_ChIP-Seq_DFB_Human	1.59461395
21	BCAT_22108803_ChIP-Seq_LS180_Human	1.55582241
22	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.54156004
23	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.48430484
24	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.45038273
25	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.45038273
26	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.44643358
27	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.44128162
28	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.37429360
29	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.36972355
30	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.36408882
31	REST_21632747_ChIP-Seq_MESCs_Mouse	1.34948428
32	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.34693954
33	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.34642707
34	VDR_24787735_ChIP-Seq_THP-1_Human	1.34495994
35	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.33895589
36	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.31917497
37	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.31026680
38	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.29449178
39	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.28341880
40	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28272982
41	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.27713050
42	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.27394279
43	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.25645667
44	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.23193082
45	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.23193082
46	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.22570186
47	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.22065740
48	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.20829888
49	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.19669569
50	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.18455453
51	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.17778433
52	ER_23166858_ChIP-Seq_MCF-7_Human	1.15805803
53	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.14562596
54	GATA1_22025678_ChIP-Seq_K562_Human	1.14036383
55	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.13824459
56	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.13507846
57	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.13292406
58	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.12782795
59	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.11829048
60	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.10947008
61	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.09646252
62	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.09171014
63	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.09064391
64	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.08159115
65	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.06547265
66	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.06513123
67	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.05994195
68	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.05812866
69	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.04210972
70	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.03870955
71	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.03136622
72	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.02117957
73	BCL6_27268052_Chip-Seq_Bcells_Human	1.02028857
74	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.01203113
75	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.00666858
76	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.00634611
77	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.99790667
78	CJUN_26792858_Chip-Seq_BT549_Human	0.99104891
79	ZNF274_21170338_ChIP-Seq_K562_Hela	0.98863924
80	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.96794550
81	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.96431005
82	RXR_22108803_ChIP-Seq_LS180_Human	0.95967491
83	RAC3_21632823_ChIP-Seq_H3396_Human	0.95478766
84	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.95103695
85	SMAD4_21799915_ChIP-Seq_A2780_Human	0.94733283
86	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.93547089
87	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.93521174
88	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.93198641
89	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.93042795
90	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.92728865
91	ERA_21632823_ChIP-Seq_H3396_Human	0.92345848
92	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.91413695
93	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.89834108
94	IRF8_27001747_Chip-Seq_BMDM_Mouse	0.89636544
95	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.89454488
96	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.89158755
97	AR_25329375_ChIP-Seq_VCAP_Human	0.88921647
98	SOX2_20726797_ChIP-Seq_SW620_Human	0.88822191
99	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.88624839
100	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.88428222
101	AHR_22903824_ChIP-Seq_MCF-7_Human	0.88181800
102	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.87666730
103	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.87493087
104	TAF15_26573619_Chip-Seq_HEK293_Human	0.86812000
105	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.86671037
106	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.86021858
107	SPI1_23127762_ChIP-Seq_K562_Human	0.85982165
108	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.85518656
109	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.83512429
110	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	0.82928430
111	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.82916423
112	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.82822085
113	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.82589125
114	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.82321287
115	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.82251617
116	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.82169431
117	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.81949056
118	TP53_16413492_ChIP-PET_HCT116_Human	0.81902125
119	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.81608002
120	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.81100717
121	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.80074620
122	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.79580060
123	* NANOG_20526341_ChIP-Seq_ESCs_Human	0.79497498
124	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.79205268
125	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.78991109
126	* MECOM_23826213_ChIP-Seq_KASUMI_Mouse	0.78990753
127	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.78082356
128	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	0.77776297
129	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.77756474
130	HTT_18923047_ChIP-ChIP_STHdh_Human	0.77639486
131	STAT3_23295773_ChIP-Seq_U87_Human	0.77121000
132	GATA1_19941826_ChIP-Seq_K562_Human	0.76557708
133	TRIM28_21343339_ChIP-Seq_HEK293_Human	0.76519821
134	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.76201273
135	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.75884842
136	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.75834791
137	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.75821810
138	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.75614547
139	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.75351262
140	BCOR_27268052_Chip-Seq_Bcells_Human	0.75100293
141	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.73831226
142	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.73645465
143	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.73276978
144	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.72368534
145	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.72362371
146	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.72272336

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	4.59455871
2	MP0005085_abnormal_gallbladder_physiolo	3.46953122
3	MP0005360_urolithiasis	3.42763814
4	MP0005365_abnormal_bile_salt	3.24417868
5	MP0005058_abnormal_lysosome_morphology	2.82670109
6	MP0004859_abnormal_synaptic_plasticity	2.76324309
7	MP0003724_increased_susceptibility_to	2.61856788
8	MP0000015_abnormal_ear_pigmentation	2.53274220
9	MP0002909_abnormal_adrenal_gland	2.50173063
10	MP0008875_abnormal_xenobiotic_pharmacok	2.43508483
11	MP0010368_abnormal_lymphatic_system	2.38680349
12	MP0009840_abnormal_foam_cell	2.38261077
13	MP0003690_abnormal_glial_cell	2.29489103
14	MP0004130_abnormal_muscle_cell	2.28797068
15	MP0003191_abnormal_cellular_cholesterol	2.22836161
16	MP0004270_analgesia	2.15797748
17	MP0010329_abnormal_lipoprotein_level	2.08529827
18	MP0009780_abnormal_chondrocyte_physiolo	2.02555803
19	MP0003329_amyloid_beta_deposits	2.02086431
20	MP0003195_calcinosis	1.99640917
21	MP0009764_decreased_sensitivity_to	1.97095585
22	MP0002090_abnormal_vision	1.93983293
23	MP0003075_altered_response_to	1.93904951
24	MP0003252_abnormal_bile_duct	1.91399658
25	MP0005083_abnormal_biliary_tract	1.87906548
26	MP0000604_amyloidosis	1.87536307
27	MP0003635_abnormal_synaptic_transmissio	1.82922649
28	MP0001666_abnormal_nutrient_absorption	1.81824484
29	MP0005451_abnormal_body_composition	1.80499105
30	MP0002064_seizures	1.74470769
31	MP0004043_abnormal_pH_regulation	1.73179033
32	MP0002118_abnormal_lipid_homeostasis	1.72371294
33	MP0009785_altered_susceptibility_to	1.61418525
34	MP0001727_abnormal_embryo_implantation	1.58821825
35	MP0003172_abnormal_lysosome_physiology	1.58323502
36	MP0003880_abnormal_central_pattern	1.57661544
37	MP0005332_abnormal_amino_acid	1.57312227
38	MP0001533_abnormal_skeleton_physiology	1.56440089
39	MP0003436_decreased_susceptibility_to	1.55941198
40	MP0000372_irregular_coat_pigmentation	1.55092538
41	MP0009745_abnormal_behavioral_response	1.49790084
42	MP0010386_abnormal_urinary_bladder	1.48610393
43	MP0001501_abnormal_sleep_pattern	1.46561197
44	MP0000920_abnormal_myelination	1.45951788
45	MP0001764_abnormal_homeostasis	1.43630470
46	MP0002419_abnormal_innate_immunity	1.40813933
47	MP0005174_abnormal_tail_pigmentation	1.39431497
48	MP0001873_stomach_inflammation	1.38723530
49	MP0009046_muscle_twitch	1.36910541
50	MP0002063_abnormal_learning/memory/cond	1.36698063
51	MP0003633_abnormal_nervous_system	1.36633054
52	MP0001851_eye_inflammation	1.34726086
53	MP0002837_dystrophic_cardiac_calcinosis	1.32713468
54	MP0001486_abnormal_startle_reflex	1.30627966
55	MP0004858_abnormal_nervous_system	1.30396801
56	MP0001986_abnormal_taste_sensitivity	1.28571662
57	MP0005535_abnormal_body_temperature	1.28558014
58	MP0002734_abnormal_mechanical_nocicepti	1.27336922
59	MP0001968_abnormal_touch/_nociception	1.25034544
60	MP0000609_abnormal_liver_physiology	1.23400236
61	MP0003868_abnormal_feces_composition	1.22324171
62	MP0002272_abnormal_nervous_system	1.21967168
63	MP0005584_abnormal_enzyme/coenzyme_acti	1.21047426
64	MP0002572_abnormal_emotion/affect_behav	1.20468250
65	MP0000343_altered_response_to	1.19549946
66	MP0002736_abnormal_nociception_after	1.17716927
67	MP0002822_catalepsy	1.16771301
68	MP0000371_diluted_coat_color	1.15335535
69	MP0003879_abnormal_hair_cell	1.14982419
70	MP0004883_abnormal_blood_vessel	1.12770901
71	MP0003631_nervous_system_phenotype	1.10801837
72	MP0003183_abnormal_peptide_metabolism	1.10488562
73	MP0005167_abnormal_blood-brain_barrier	1.09482968
74	MP0006082_CNS_inflammation	1.09373768
75	MP0005646_abnormal_pituitary_gland	1.09072673
76	MP0002876_abnormal_thyroid_physiology	1.09044638
77	MP0003806_abnormal_nucleotide_metabolis	1.09035017
78	MP0009643_abnormal_urine_homeostasis	1.07675721
79	MP0002078_abnormal_glucose_homeostasis	1.04061968
80	MP0002168_other_aberrant_phenotype	1.02379049
81	MP0005551_abnormal_eye_electrophysiolog	1.02137706
82	MP0008260_abnormal_autophagy	1.01392043
83	MP0008874_decreased_physiological_sensi	1.00199895
84	MP0002933_joint_inflammation	0.99329142
85	MP0002229_neurodegeneration	0.98988806
86	MP0003646_muscle_fatigue	0.98582976
87	MP0002693_abnormal_pancreas_physiology	0.97058377
88	MP0005166_decreased_susceptibility_to	0.96163317
89	MP0002148_abnormal_hypersensitivity_rea	0.95919630
90	MP0004019_abnormal_vitamin_homeostasis	0.95339821
91	MP0003632_abnormal_nervous_system	0.95255750
92	MP0000013_abnormal_adipose_tissue	0.94220195
93	MP0003300_gastrointestinal_ulcer	0.92650004
94	MP0004885_abnormal_endolymph	0.91373542
95	MP0005386_behavior/neurological_phenoty	0.91263387
96	MP0004924_abnormal_behavior	0.91263387
97	MP0003634_abnormal_glial_cell	0.91120801
98	MP0005025_abnormal_response_to	0.90827652
99	MP0005075_abnormal_melanosome_morpholog	0.90621084
100	MP0005390_skeleton_phenotype	0.90553808
101	MP0004484_altered_response_of	0.89534678
102	MP0005319_abnormal_enzyme/_coenzyme	0.88650893
103	MP0002998_abnormal_bone_remodeling	0.87989626
104	MP0005448_abnormal_energy_balance	0.87289997
105	MP0002067_abnormal_sensory_capabilities	0.85493062
106	MP0004036_abnormal_muscle_relaxation	0.85475319
107	MP0001970_abnormal_pain_threshold	0.85162362
108	MP0005595_abnormal_vascular_smooth	0.84750159
109	MP0005409_darkened_coat_color	0.84549139
110	MP0005387_immune_system_phenotype	0.84483155
111	MP0001790_abnormal_immune_system	0.84483155
112	MP0002295_abnormal_pulmonary_circulatio	0.84436571
113	MP0002138_abnormal_hepatobiliary_system	0.84021123
114	MP0005171_absent_coat_pigmentation	0.83783407
115	MP0006276_abnormal_autonomic_nervous	0.83295399
116	MP0002733_abnormal_thermal_nociception	0.82055220
117	MP0000569_abnormal_digit_pigmentation	0.80937654
118	MP0004510_myositis	0.80854326
119	MP0005334_abnormal_fat_pad	0.80464167
120	MP0008438_abnormal_cutaneous_collagen	0.80296586
121	MP0003303_peritoneal_inflammation	0.80217746
122	MP0004185_abnormal_adipocyte_glucose	0.79808992
123	MP0001905_abnormal_dopamine_level	0.79228727
124	MP0003136_yellow_coat_color	0.78393680
125	MP0001502_abnormal_circadian_rhythm	0.77272196
126	MP0003045_fibrosis	0.77090313
127	MP0001440_abnormal_grooming_behavior	0.77029398
128	MP0001800_abnormal_humoral_immune	0.76219975
129	MP0004142_abnormal_muscle_tone	0.76101705
130	MP0008569_lethality_at_weaning	0.75781302
131	MP0009765_abnormal_xenobiotic_induced	0.74566857
132	MP0000230_abnormal_systemic_arterial	0.74233679
133	MP0009115_abnormal_fat_cell	0.74220141
134	MP0003656_abnormal_erythrocyte_physiolo	0.73924197
135	MP0008469_abnormal_protein_level	0.73718742
136	MP0001765_abnormal_ion_homeostasis	0.73468476
137	MP0005464_abnormal_platelet_physiology	0.73136795
138	MP0003953_abnormal_hormone_level	0.72326046
139	MP0004742_abnormal_vestibular_system	0.71948064
140	MP0002066_abnormal_motor_capabilities/c	0.71698604
141	MP0002735_abnormal_chemical_nociception	0.70805180
142	MP0005164_abnormal_response_to	0.70697158
143	MP0005410_abnormal_fertilization	0.70169813
144	MP0001915_intracranial_hemorrhage	0.69300606
145	MP0002723_abnormal_immune_serum	0.67897960
146	MP0000685_abnormal_immune_system	0.65938465
147	MP0005647_abnormal_sex_gland	0.65732341
148	MP0005376_homeostasis/metabolism_phenot	0.65699222
149	MP0005000_abnormal_immune_tolerance	0.65636353
150	MP0000767_abnormal_smooth_muscle	0.65433143

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Striae distensae (HP:0001065)	6.03067146
2	Metaphyseal cupping (HP:0003021)	4.66992879
3	Abnormality of aromatic amino acid family metabolism (HP:0004338)	4.57779559
4	Cupped ribs (HP:0000887)	4.49949122
5	Abnormality of macular pigmentation (HP:0008002)	4.19260799
6	Constricted visual fields (HP:0001133)	4.15709862
7	Round ear (HP:0100830)	4.01257401
8	Cone-rod dystrophy (HP:0000548)	3.99438233
9	Toxemia of pregnancy (HP:0100603)	3.87372812
10	Ovoid vertebral bodies (HP:0003300)	3.86390288
11	Deep venous thrombosis (HP:0002625)	3.81258436
12	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.78564115
13	Complement deficiency (HP:0004431)	3.73368702
14	Neurofibrillary tangles (HP:0002185)	3.59751703
15	Intrahepatic cholestasis (HP:0001406)	3.59422709
16	Increased cerebral lipofuscin (HP:0011813)	3.57498160
17	Focal motor seizures (HP:0011153)	3.54920822
18	Increased neuronal autofluorescent lipopigment (HP:0002074)	3.31443075
19	Attenuation of retinal blood vessels (HP:0007843)	3.29924357
20	Supranuclear gaze palsy (HP:0000605)	3.28855863
21	Prolonged partial thromboplastin time (HP:0003645)	3.10145957
22	Visual hallucinations (HP:0002367)	3.06433849
23	Tibial bowing (HP:0002982)	3.00820807
24	Systemic lupus erythematosus (HP:0002725)	2.99107776
25	Cerebral inclusion bodies (HP:0100314)	2.97604477
26	Axonal loss (HP:0003447)	2.95811152
27	Dysostosis multiplex (HP:0000943)	2.89527422
28	Hyperventilation (HP:0002883)	2.88899295
29	Orchitis (HP:0100796)	2.77825202
30	Myokymia (HP:0002411)	2.76517067
31	Gingival bleeding (HP:0000225)	2.76004909
32	Xanthomatosis (HP:0000991)	2.74803231
33	Glomerulonephritis (HP:0000099)	2.73100308
34	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.64263417
35	Generalized tonic-clonic seizures (HP:0002069)	2.63911384
36	Ocular albinism (HP:0001107)	2.60495165
37	Coxa vara (HP:0002812)	2.57264513
38	Epidermoid cyst (HP:0200040)	2.54402665
39	Action tremor (HP:0002345)	2.53489214
40	Sensorimotor neuropathy (HP:0007141)	2.51741504
41	Ketosis (HP:0001946)	2.49822442
42	Abnormality of the common coagulation pathway (HP:0010990)	2.47742128
43	Myositis (HP:0100614)	2.47187739
44	Hematochezia (HP:0002573)	2.47118457
45	Cerebral hemorrhage (HP:0001342)	2.45252364
46	Epileptic encephalopathy (HP:0200134)	2.45230445
47	Decreased muscle mass (HP:0003199)	2.44059663
48	Abnormality of complement system (HP:0005339)	2.43739174
49	Large earlobe (HP:0009748)	2.43552643
50	Focal seizures (HP:0007359)	2.43296383
51	Abnormal gallbladder morphology (HP:0012437)	2.41619089
52	Hyperlipoproteinemia (HP:0010980)	2.40985458
53	Conjugated hyperbilirubinemia (HP:0002908)	2.40505071
54	Hypoglycemic coma (HP:0001325)	2.39344018
55	Albinism (HP:0001022)	2.39099645
56	Urinary glycosaminoglycan excretion (HP:0003541)	2.38404680
57	Mucopolysacchariduria (HP:0008155)	2.38404680
58	Femoral bowing (HP:0002980)	2.38043297
59	Vacuolated lymphocytes (HP:0001922)	2.36990909
60	Hypochromic microcytic anemia (HP:0004840)	2.36128036
61	Oligodontia (HP:0000677)	2.34858640
62	Congenital stationary night blindness (HP:0007642)	2.31964530
63	Retrobulbar optic neuritis (HP:0100654)	2.31016084
64	Optic neuritis (HP:0100653)	2.31016084
65	Joint hemorrhage (HP:0005261)	2.30597261
66	Pheochromocytoma (HP:0002666)	2.30017264
67	Amyloidosis (HP:0011034)	2.29851210
68	Cholelithiasis (HP:0001081)	2.29447084
69	Colitis (HP:0002583)	2.28540581
70	Progressive neurologic deterioration (HP:0002344)	2.28488700
71	Peritonitis (HP:0002586)	2.27837270
72	Generalized hypopigmentation (HP:0007513)	2.27552580
73	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.25477324
74	Recurrent gram-negative bacterial infections (HP:0005420)	2.25255159
75	Widely spaced teeth (HP:0000687)	2.23729897
76	Iris hypopigmentation (HP:0007730)	2.20906174
77	Hypoglycemic seizures (HP:0002173)	2.19320707
78	Abnormality of polysaccharide metabolism (HP:0011012)	2.18147837
79	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.18147837
80	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.18147837
81	Mesangial abnormality (HP:0001966)	2.18146890
82	Stomatitis (HP:0010280)	2.17828166
83	Status epilepticus (HP:0002133)	2.17199361
84	Congenital sensorineural hearing impairment (HP:0008527)	2.15143175
85	Spastic tetraparesis (HP:0001285)	2.15053121
86	Hypobetalipoproteinemia (HP:0003563)	2.14476565
87	Hyperammonemia (HP:0001987)	2.13727168
88	Inability to walk (HP:0002540)	2.12974309
89	Cholecystitis (HP:0001082)	2.11270846
90	Abnormal gallbladder physiology (HP:0012438)	2.11270846
91	Lack of skin elasticity (HP:0100679)	2.11202140
92	Generalized myoclonic seizures (HP:0002123)	2.11178537
93	Spontaneous abortion (HP:0005268)	2.10227700
94	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.08825958
95	Abnormality of the intrinsic pathway (HP:0010989)	2.08052990
96	Retinal atrophy (HP:0001105)	2.07797927
97	Fat malabsorption (HP:0002630)	2.05553139
98	Delayed CNS myelination (HP:0002188)	2.05534948
99	Absence seizures (HP:0002121)	2.05273865
100	Volvulus (HP:0002580)	2.04084062
101	Abnormality of macrophages (HP:0004311)	2.01643714
102	Skin nodule (HP:0200036)	2.01563409
103	Irritability (HP:0000737)	2.00852079
104	Metabolic alkalosis (HP:0200114)	2.00531111
105	Abnormality of methionine metabolism (HP:0010901)	2.00339547
106	Mutism (HP:0002300)	2.00102556
107	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.99467023
108	Ulnar claw (HP:0001178)	1.99040176
109	Generalized aminoaciduria (HP:0002909)	1.98663022
110	Ketoacidosis (HP:0001993)	1.97336310
111	Dialeptic seizures (HP:0011146)	1.96547160
112	Large for gestational age (HP:0001520)	1.96200908
113	Hypochromic anemia (HP:0001931)	1.95957877
114	Abnormality of glycolipid metabolism (HP:0010969)	1.95659553
115	Abnormality of liposaccharide metabolism (HP:0010968)	1.95659553
116	Abnormality of glycosphingolipid metabolism (HP:0004343)	1.95659553
117	Hypoalphalipoproteinemia (HP:0003233)	1.95231526
118	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.95105329
119	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.94738236
120	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	1.94263190
121	Prominent supraorbital ridges (HP:0000336)	1.92689079
122	Neuronal loss in central nervous system (HP:0002529)	1.91654200
123	Hyperinsulinemic hypoglycemia (HP:0000825)	1.90653994
124	Neuroendocrine neoplasm (HP:0100634)	1.89601308
125	J-shaped sella turcica (HP:0002680)	1.89562708
126	Intention tremor (HP:0002080)	1.88326861
127	Vascular calcification (HP:0004934)	1.87865116
128	Hypolipoproteinemia (HP:0010981)	1.86942159
129	Decreased circulating renin level (HP:0003351)	1.86807036
130	Abnormality of fatty-acid metabolism (HP:0004359)	1.85567313
131	Mitral stenosis (HP:0001718)	1.85554874
132	Postural instability (HP:0002172)	1.85226206
133	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.83938848
134	Spastic paraparesis (HP:0002313)	1.83096814
135	Hyperbilirubinemia (HP:0002904)	1.82788405
136	Broad nasal tip (HP:0000455)	1.82606483
137	Abnormality of the gallbladder (HP:0005264)	1.82233297
138	Dysdiadochokinesis (HP:0002075)	1.81319610
139	Atonic seizures (HP:0010819)	1.81110754
140	Brushfield spots (HP:0001088)	1.80831719
141	Symptomatic seizures (HP:0011145)	1.80569811
142	Intellectual disability, progressive (HP:0006887)	1.78847222
143	Alkalosis (HP:0001948)	1.78767739
144	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.77011121
145	Dicarboxylic aciduria (HP:0003215)	1.77011121
146	Absent speech (HP:0001344)	1.76374956
147	Pulmonary embolism (HP:0002204)	1.73442995
148	Dysmetria (HP:0001310)	1.73036783
149	Nephritis (HP:0000123)	1.73021705
150	Choroideremia (HP:0001139)	1.71511026
151	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.70949700
152	Lymphedema (HP:0001004)	1.70432785
153	Prolonged neonatal jaundice (HP:0006579)	1.69013828
154	Disproportionate short-trunk short stature (HP:0003521)	1.68959982
155	Recurrent abscess formation (HP:0002722)	1.68848423
156	Generalized hypopigmentation of hair (HP:0011358)	1.68767156
157	Acne (HP:0001061)	1.66741415
158	Progressive inability to walk (HP:0002505)	1.64094865
159	Photophobia (HP:0000613)	1.62591693
160	Recurrent bacterial skin infections (HP:0005406)	1.61559137
161	Elevated erythrocyte sedimentation rate (HP:0003565)	1.59990503
162	Hypoplastic ischia (HP:0003175)	1.59594742
163	Intellectual disability, severe (HP:0010864)	1.57760004
164	Amelogenesis imperfecta (HP:0000705)	1.57486611
165	Progressive visual loss (HP:0000529)	1.56561085
166	Hemiplegia (HP:0002301)	1.56148381
167	Freckling (HP:0001480)	1.56098074

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS1	3.14481068
2	SIK2	3.14207796
3	ZAK	3.02572646
4	CAMKK2	2.82292378
5	ARAF	2.76089705
6	MAP3K9	2.72598224
7	CAMK1D	2.56358494
8	MAP3K7	2.37519022
9	RIPK4	2.36323633
10	CAMKK1	2.24661098
11	KSR2	2.21489338
12	NTRK1	2.12131535
13	CAMK1G	1.93606754
14	ERN1	1.86679418
15	TNK2	1.83632037
16	SCYL2	1.77450685
17	MST4	1.75989359
18	NTRK3	1.71293952
19	PAK6	1.68344494
20	BCKDK	1.66760777
21	STK11	1.62707882
22	PRKD3	1.59771334
23	LMTK2	1.51829968
24	STK38	1.49809583
25	DAPK2	1.44980309
26	TEC	1.42061488
27	MAP3K3	1.36732750
28	ADRBK1	1.34595192
29	EPHB1	1.33166057
30	MET	1.32263217
31	IKBKB	1.29457404
32	CSK	1.27811703
33	MAP3K13	1.26594773
34	PINK1	1.26200146
35	OXSR1	1.23606205
36	MAP4K1	1.23223677
37	JAK1	1.22955143
38	MAP2K3	1.22901057
39	ZAP70	1.22107739
40	INSRR	1.21610333
41	MST1R	1.20265216
42	MAP3K4	1.19827863
43	MAPK13	1.19821825
44	EPHB2	1.17061839
45	ACVR1B	1.16998717
46	TAOK3	1.15952547
47	PRKAA2	1.15819613
48	MAP3K2	1.14186757
49	PDK2	1.11947890
50	PRKCH	1.09984639
51	EPHA4	1.09319978
52	NUAK1	1.08742271
53	EPHA3	1.07574327
54	MAPKAPK5	1.07521260
55	SIK3	1.06468710
56	PTK6	1.04416749
57	FRK	1.02708370
58	PDPK1	1.01962676
59	KSR1	1.01377251
60	MAP3K10	1.00349170
61	MAP2K4	0.99139803
62	IRAK4	0.97576088
63	FES	0.97511629
64	TYK2	0.97310654
65	FGFR2	0.96810551
66	MARK3	0.96042443
67	CDK19	0.95220832
68	MAP2K7	0.94994031
69	TRIB3	0.94522379
70	JAK2	0.93801508
71	MUSK	0.93176302
72	FGFR4	0.92447449
73	CDK5	0.90455639
74	TBK1	0.89727762
75	TGFBR2	0.88140956
76	GRK1	0.88030679
77	PRPF4B	0.87946947
78	IKBKE	0.86703913
79	CASK	0.86595114
80	PAK3	0.85787826
81	SYK	0.85149157
82	TESK2	0.85086129
83	SGK223	0.84361121
84	SGK494	0.84361121
85	RAF1	0.83342343
86	NTRK2	0.82297821
87	PDK1	0.81553401
88	CSF1R	0.81088852
89	MAP3K11	0.79855784
90	PRKG2	0.79227184
91	STK39	0.78885437
92	TXK	0.78343572
93	MAP3K6	0.78310356
94	MAPK12	0.77502123
95	TAOK1	0.77292498
96	GRK6	0.76140588
97	MINK1	0.75877729
98	MAP2K6	0.75805949
99	ERBB4	0.74534502
100	MARK1	0.74329001
101	TESK1	0.72889023
102	CAMK4	0.71841904
103	RET	0.71127430
104	PTK2B	0.70999971
105	SIK1	0.70899819
106	JAK3	0.69547757
107	MAP2K1	0.68389946
108	PRKD2	0.68358863
109	CAMK2G	0.65631511
110	ADRBK2	0.64622391
111	PRKAA1	0.64343453
112	PRKACG	0.63681779
113	RPS6KA2	0.62379698
114	MAP3K1	0.61997064
115	LIMK1	0.61778803
116	MAP4K2	0.61752011
117	TYRO3	0.61102268
118	DYRK1B	0.60951655
119	ABL2	0.60287722
120	FGR	0.56756882
121	PRKCZ	0.56707795
122	MYLK	0.56285674
123	BLK	0.56165043
124	BRAF	0.56022411
125	CAMK2A	0.56020714
126	SGK3	0.55829226
127	MARK2	0.55068584
128	PRKD1	0.54760840
129	KIT	0.52838821
130	MOS	0.51998037
131	FER	0.50864934
132	CAMK2B	0.49942138
133	HCK	0.49331627
134	CAMK1	0.49177210
135	GRK5	0.49026333
136	NEK2	0.48127783
137	PHKG1	0.47753906
138	PHKG2	0.47753906
139	CHUK	0.47426174
140	RPS6KB1	0.46884777
141	HIPK2	0.46703174
142	PRKCE	0.46416146
143	DYRK2	0.45478275
144	PRKCG	0.44944878
145	FYN	0.44861714
146	AKT3	0.44757958
147	WNK3	0.43345026
148	CDC42BPA	0.43251424
149	DAPK3	0.43154461
150	PDGFRB	0.42762122
151	IRAK1	0.42687384
152	MAPKAPK3	0.42452266
153	WNK1	0.41435754
154	TAOK2	0.40506102
155	CSNK1G2	0.40271545
156	SGK1	0.36487136
157	PKN1	0.36325448
158	PRKCQ	0.35544784

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nitrogen metabolism_Homo sapiens_hsa00910	3.11496052
2	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.04268111
3	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.14860135
4	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.10964255
5	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.95796849
6	Butanoate metabolism_Homo sapiens_hsa00650	1.88386265
7	Arginine biosynthesis_Homo sapiens_hsa00220	1.87952682
8	Sulfur metabolism_Homo sapiens_hsa00920	1.72765502
9	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.67980532
10	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.64605443
11	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.63962726
12	Tryptophan metabolism_Homo sapiens_hsa00380	1.60319760
13	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.51122851
14	Complement and coagulation cascades_Homo sapiens_hsa04610	1.50537007
15	Propanoate metabolism_Homo sapiens_hsa00640	1.47419652
16	Fatty acid degradation_Homo sapiens_hsa00071	1.46617930
17	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.44253964
18	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.42653585
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.40637407
20	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.35324429
21	PPAR signaling pathway_Homo sapiens_hsa03320	1.33874871
22	Histidine metabolism_Homo sapiens_hsa00340	1.32357212
23	Fatty acid elongation_Homo sapiens_hsa00062	1.31190244
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.30479048
25	Fatty acid metabolism_Homo sapiens_hsa01212	1.29946992
26	Osteoclast differentiation_Homo sapiens_hsa04380	1.29605461
27	Bile secretion_Homo sapiens_hsa04976	1.20845417
28	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.19101469
29	Peroxisome_Homo sapiens_hsa04146	1.16953449
30	Collecting duct acid secretion_Homo sapiens_hsa04966	1.15769046
31	Lysosome_Homo sapiens_hsa04142	1.15438912
32	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.14108138
33	Phototransduction_Homo sapiens_hsa04744	1.12239256
34	Fat digestion and absorption_Homo sapiens_hsa04975	1.11121823
35	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.04511316
36	GABAergic synapse_Homo sapiens_hsa04727	1.03762979
37	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.03160300
38	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.02076382
39	Insulin secretion_Homo sapiens_hsa04911	0.99555703
40	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.98674791
41	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.97998332
42	ABC transporters_Homo sapiens_hsa02010	0.95157693
43	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.93355773
44	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.92946247
45	Pyruvate metabolism_Homo sapiens_hsa00620	0.92051080
46	beta-Alanine metabolism_Homo sapiens_hsa00410	0.91331682
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.90032288
48	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.88981128
49	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.88671628
50	Steroid biosynthesis_Homo sapiens_hsa00100	0.87624848
51	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.87566664
52	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.86952510
53	Ether lipid metabolism_Homo sapiens_hsa00565	0.86697722
54	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.86599641
55	Caffeine metabolism_Homo sapiens_hsa00232	0.83981811
56	Linoleic acid metabolism_Homo sapiens_hsa00591	0.83961261
57	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.83872841
58	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.83757620
59	Pertussis_Homo sapiens_hsa05133	0.82363244
60	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.81756245
61	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.80491274
62	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.77995933
63	Phenylalanine metabolism_Homo sapiens_hsa00360	0.76524953
64	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.76435683
65	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.76392726
66	Malaria_Homo sapiens_hsa05144	0.76379099
67	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.75696636
68	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.75511060
69	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.75324888
70	Prion diseases_Homo sapiens_hsa05020	0.73759250
71	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.73049683
72	Glutamatergic synapse_Homo sapiens_hsa04724	0.72974465
73	Morphine addiction_Homo sapiens_hsa05032	0.72625267
74	Vibrio cholerae infection_Homo sapiens_hsa05110	0.72056679
75	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.71053379
76	Retinol metabolism_Homo sapiens_hsa00830	0.70393161
77	Cocaine addiction_Homo sapiens_hsa05030	0.70181657
78	Glycerolipid metabolism_Homo sapiens_hsa00561	0.69403394
79	African trypanosomiasis_Homo sapiens_hsa05143	0.68536654
80	Circadian entrainment_Homo sapiens_hsa04713	0.68443996
81	Salivary secretion_Homo sapiens_hsa04970	0.67411974
82	Nicotine addiction_Homo sapiens_hsa05033	0.66908056
83	Long-term potentiation_Homo sapiens_hsa04720	0.66395712
84	TNF signaling pathway_Homo sapiens_hsa04668	0.65198337
85	Pancreatic secretion_Homo sapiens_hsa04972	0.63541552
86	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.63370256
87	FoxO signaling pathway_Homo sapiens_hsa04068	0.63283115
88	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.62817172
89	Olfactory transduction_Homo sapiens_hsa04740	0.61930114
90	Type II diabetes mellitus_Homo sapiens_hsa04930	0.61903807
91	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.61515147
92	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.61093007
93	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.60919605
94	Renin secretion_Homo sapiens_hsa04924	0.60464885
95	Regulation of autophagy_Homo sapiens_hsa04140	0.60014159
96	Cholinergic synapse_Homo sapiens_hsa04725	0.58834027
97	Amphetamine addiction_Homo sapiens_hsa05031	0.58675700
98	Taste transduction_Homo sapiens_hsa04742	0.58660745
99	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.56996936
100	Sphingolipid metabolism_Homo sapiens_hsa00600	0.56966526
101	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.55173262
102	Gastric acid secretion_Homo sapiens_hsa04971	0.54758460
103	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.53519201
104	Glucagon signaling pathway_Homo sapiens_hsa04922	0.53263343
105	Carbon metabolism_Homo sapiens_hsa01200	0.52552043
106	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.52348248
107	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.52118385
108	Other glycan degradation_Homo sapiens_hsa00511	0.51968036
109	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.51180292
110	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.50626933
111	Dopaminergic synapse_Homo sapiens_hsa04728	0.50589900
112	Hepatitis C_Homo sapiens_hsa05160	0.50408501
113	Tuberculosis_Homo sapiens_hsa05152	0.49665920
114	Rheumatoid arthritis_Homo sapiens_hsa05323	0.49552931
115	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.49393760
116	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.49112268
117	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.48325442
118	Tyrosine metabolism_Homo sapiens_hsa00350	0.47854480
119	Measles_Homo sapiens_hsa05162	0.46940118
120	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.46016985
121	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.43850497
122	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.43017943
123	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.42505233
124	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.42347715
125	Insulin resistance_Homo sapiens_hsa04931	0.41784158
126	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.41585451
127	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.40609549
128	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.40462155
129	Phagosome_Homo sapiens_hsa04145	0.40438336
130	Axon guidance_Homo sapiens_hsa04360	0.39742870
131	Amoebiasis_Homo sapiens_hsa05146	0.39633804
132	Shigellosis_Homo sapiens_hsa05131	0.39534883
133	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.39053195
134	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.38745803
135	Mineral absorption_Homo sapiens_hsa04978	0.38310033
136	Prolactin signaling pathway_Homo sapiens_hsa04917	0.37720971
137	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.37702117
138	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.37580637
139	Arginine and proline metabolism_Homo sapiens_hsa00330	0.37386762
140	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.36490286
141	Calcium signaling pathway_Homo sapiens_hsa04020	0.35810452
142	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.35689349
143	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.35675430
144	Platelet activation_Homo sapiens_hsa04611	0.35248807
145	Circadian rhythm_Homo sapiens_hsa04710	0.34720617

KCTD21

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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