

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | axon ensheathment in central nervous system (GO:0032291) | 7.92663437 |
| 2 | central nervous system myelination (GO:0022010) | 7.92663437 |
| 3 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 6.40339593 |
| 4 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800) | 5.29086903 |
| 5 | presynaptic membrane assembly (GO:0097105) | 5.26201849 |
| 6 | presynaptic membrane organization (GO:0097090) | 5.14287155 |
| 7 | fatty acid elongation (GO:0030497) | 5.03861633 |
| 8 | neuron cell-cell adhesion (GO:0007158) | 5.00197217 |
| 9 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 4.76264715 |
| 10 | long-chain fatty acid biosynthetic process (GO:0042759) | 4.71688009 |
| 11 | L-amino acid import (GO:0043092) | 4.60771805 |
| 12 | negative regulation of neurotransmitter transport (GO:0051589) | 4.58511746 |
| 13 | nucleobase catabolic process (GO:0046113) | 4.55207694 |
| 14 | myelination (GO:0042552) | 4.52825136 |
| 15 | ensheathment of neurons (GO:0007272) | 4.48365806 |
| 16 | axon ensheathment (GO:0008366) | 4.48365806 |
| 17 | positive regulation of neurotransmitter secretion (GO:0001956) | 4.45576999 |
| 18 | cellular potassium ion homeostasis (GO:0030007) | 4.40702394 |
| 19 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.30525739 |
| 20 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 4.14048922 |
| 21 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.03962345 |
| 22 | regulation of clathrin-mediated endocytosis (GO:2000369) | 4.01573235 |
| 23 | positive regulation of neurotransmitter transport (GO:0051590) | 3.98788353 |
| 24 | negative regulation of neurotransmitter secretion (GO:0046929) | 3.93270259 |
| 25 | glutamate receptor signaling pathway (GO:0007215) | 3.92603240 |
| 26 | negative regulation of protein localization to cell surface (GO:2000009) | 3.84178288 |
| 27 | neuron recognition (GO:0008038) | 3.81768878 |
| 28 | neuronal action potential propagation (GO:0019227) | 3.81413331 |
| 29 | neurotransmitter secretion (GO:0007269) | 3.77050265 |
| 30 | regulation of transforming growth factor beta1 production (GO:0032908) | 3.75245991 |
| 31 | sodium ion export (GO:0071436) | 3.73882368 |
| 32 | mesenchymal-epithelial cell signaling (GO:0060638) | 3.73481579 |
| 33 | amino acid import (GO:0043090) | 3.71933765 |
| 34 | oligodendrocyte differentiation (GO:0048709) | 3.63946181 |
| 35 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 3.62216724 |
| 36 | transmission of nerve impulse (GO:0019226) | 3.60546212 |
| 37 | atrial cardiac muscle cell action potential (GO:0086014) | 3.58667901 |
| 38 | vocalization behavior (GO:0071625) | 3.58189483 |
| 39 | protein localization to synapse (GO:0035418) | 3.57932179 |
| 40 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.57584823 |
| 41 | synaptic transmission, glutamatergic (GO:0035249) | 3.55843342 |
| 42 | establishment of mitochondrion localization (GO:0051654) | 3.55754735 |
| 43 | response to methylmercury (GO:0051597) | 3.52805087 |
| 44 | ADP metabolic process (GO:0046031) | 3.51669085 |
| 45 | locomotory exploration behavior (GO:0035641) | 3.50572372 |
| 46 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.50496972 |
| 47 | postsynaptic membrane organization (GO:0001941) | 3.47449289 |
| 48 | cerebellar granule cell differentiation (GO:0021707) | 3.47111552 |
| 49 | apical protein localization (GO:0045176) | 3.42112552 |
| 50 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.41131594 |
| 51 | synaptic vesicle exocytosis (GO:0016079) | 3.40947542 |
| 52 | regulation of collateral sprouting (GO:0048670) | 3.40032117 |
| 53 | neuron-neuron synaptic transmission (GO:0007270) | 3.39905265 |
| 54 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.39374780 |
| 55 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.37839379 |
| 56 | dendritic spine morphogenesis (GO:0060997) | 3.36987167 |
| 57 | negative regulation of peptidyl-threonine phosphorylation (GO:0010801) | 3.36947334 |
| 58 | keratinization (GO:0031424) | 3.35508223 |
| 59 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.33676220 |
| 60 | cerebellar Purkinje cell layer development (GO:0021680) | 3.33273636 |
| 61 | potassium ion homeostasis (GO:0055075) | 3.32040283 |
| 62 | axonal fasciculation (GO:0007413) | 3.31512619 |
| 63 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.29884868 |
| 64 | potassium ion import (GO:0010107) | 3.29664799 |
| 65 | cerebral cortex radially oriented cell migration (GO:0021799) | 3.28997196 |
| 66 | glycerophospholipid catabolic process (GO:0046475) | 3.28238450 |
| 67 | regulation of synaptic vesicle exocytosis (GO:2000300) | 3.24844418 |
| 68 | regulation of synapse structural plasticity (GO:0051823) | 3.24820657 |
| 69 | cornea development in camera-type eye (GO:0061303) | 3.24693929 |
| 70 | glutamate secretion (GO:0014047) | 3.21891065 |
| 71 | regulation of neurotransmitter secretion (GO:0046928) | 3.21621134 |
| 72 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.20519336 |
| 73 | long-term synaptic potentiation (GO:0060291) | 3.15631669 |
| 74 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.15166318 |
| 75 | negative regulation of dendrite morphogenesis (GO:0050774) | 3.14364884 |
| 76 | neurotransmitter uptake (GO:0001504) | 3.13481044 |
| 77 | dendrite morphogenesis (GO:0048813) | 3.11579990 |
| 78 | peptidyl-tyrosine autophosphorylation (GO:0038083) | 3.11270237 |
| 79 | cell communication by electrical coupling (GO:0010644) | 3.09712675 |
| 80 | synaptic vesicle maturation (GO:0016188) | 3.09521533 |
| 81 | adult walking behavior (GO:0007628) | 3.08426499 |
| 82 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.06897732 |
| 83 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.06440910 |
| 84 | neurotransmitter transport (GO:0006836) | 3.04432171 |
| 85 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 3.04275741 |
| 86 | cell communication involved in cardiac conduction (GO:0086065) | 3.02652043 |
| 87 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.01239922 |
| 88 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.01185300 |
| 89 | regulation of glutamate secretion (GO:0014048) | 3.00858356 |
| 90 | exploration behavior (GO:0035640) | 3.00598268 |
| 91 | gamma-aminobutyric acid transport (GO:0015812) | 3.00418684 |
| 92 | regulation of dendritic spine development (GO:0060998) | 3.00281827 |
| 93 | response to lead ion (GO:0010288) | 2.99560142 |
| 94 | positive regulation of membrane potential (GO:0045838) | 2.99173474 |
| 95 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 2.97566664 |
| 96 | regulation of postsynaptic membrane potential (GO:0060078) | 2.95287461 |
| 97 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 2.95099505 |
| 98 | negative regulation of axonogenesis (GO:0050771) | 2.93822288 |
| 99 | detection of calcium ion (GO:0005513) | 2.91949330 |
| 100 | asymmetric protein localization (GO:0008105) | 2.91301288 |
| 101 | membrane assembly (GO:0071709) | 2.89491907 |
| 102 | regulation of neurotransmitter transport (GO:0051588) | 2.88929359 |
| 103 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.88843878 |
| 104 | dendrite development (GO:0016358) | 2.88000416 |
| 105 | positive regulation of synapse assembly (GO:0051965) | 2.86999312 |
| 106 | cellular response to epinephrine stimulus (GO:0071872) | 2.86173386 |
| 107 | substantia nigra development (GO:0021762) | 2.86067701 |
| 108 | regulation of synaptic plasticity (GO:0048167) | 2.85951863 |
| 109 | dendritic spine organization (GO:0097061) | 2.85416011 |
| 110 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.84908680 |
| 111 | long-term memory (GO:0007616) | 2.84793212 |
| 112 | response to redox state (GO:0051775) | 2.84007317 |
| 113 | regulation of synaptic vesicle transport (GO:1902803) | 2.83938728 |
| 114 | myelin maintenance (GO:0043217) | 2.82216772 |
| 115 | righting reflex (GO:0060013) | 2.82126811 |
| 116 | protein localization to cilium (GO:0061512) | 2.81050705 |
| 117 | positive regulation of oligodendrocyte differentiation (GO:0048714) | 2.80826927 |
| 118 | response to histamine (GO:0034776) | 2.80037824 |
| 119 | regulation of axon regeneration (GO:0048679) | 2.79242884 |
| 120 | regulation of neuron projection regeneration (GO:0070570) | 2.79242884 |
| 121 | layer formation in cerebral cortex (GO:0021819) | 2.77707781 |
| 122 | eye photoreceptor cell differentiation (GO:0001754) | 2.77207524 |
| 123 | photoreceptor cell differentiation (GO:0046530) | 2.77207524 |
| 124 | regulation of respiratory system process (GO:0044065) | 2.75119249 |
| 125 | mechanosensory behavior (GO:0007638) | 2.75004579 |
| 126 | negative regulation of synaptic transmission (GO:0050805) | 2.74600400 |
| 127 | regulation of neurotransmitter levels (GO:0001505) | 2.73356394 |
| 128 | neuronal ion channel clustering (GO:0045161) | 2.73142205 |
| 129 | behavioral response to cocaine (GO:0048148) | 2.70476236 |
| 130 | auditory behavior (GO:0031223) | 2.70375632 |
| 131 | regulation of dopamine secretion (GO:0014059) | 2.69941332 |
| 132 | positive regulation of dendritic spine development (GO:0060999) | 2.69675695 |
| 133 | response to gravity (GO:0009629) | 2.69417424 |
| 134 | limb bud formation (GO:0060174) | 2.68499866 |
| 135 | positive regulation of epidermal growth factor-activated receptor activity (GO:0045741) | 2.68498579 |
| 136 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.67203571 |
| 137 | response to epinephrine (GO:0071871) | 2.66692538 |
| 138 | neuron remodeling (GO:0016322) | 2.65656224 |
| 139 | negative regulation of amino acid transport (GO:0051956) | 2.65388495 |
| 140 | neurofilament cytoskeleton organization (GO:0060052) | 2.65376706 |
| 141 | startle response (GO:0001964) | 2.61159285 |
| 142 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.60186314 |
| 143 | nerve growth factor signaling pathway (GO:0038180) | 2.56766528 |
| 144 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 2.56584635 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 4.70765950 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.94374242 |
| 3 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 2.95890826 |
| 4 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.89590167 |
| 5 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.86408796 |
| 6 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.81622001 |
| 7 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.49230779 |
| 8 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.45462861 |
| 9 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.45217630 |
| 10 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.41958253 |
| 11 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.41958253 |
| 12 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 2.36751125 |
| 13 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.36067560 |
| 14 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.33161329 |
| 15 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.31403474 |
| 16 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.23776854 |
| 17 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.21147408 |
| 18 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.17978591 |
| 19 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.10835528 |
| 20 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.08168957 |
| 21 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.06477003 |
| 22 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 2.05140795 |
| 23 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 2.04479096 |
| 24 | AR_21572438_ChIP-Seq_LNCaP_Human | 2.00619874 |
| 25 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.99835137 |
| 26 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.88753229 |
| 27 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.86218742 |
| 28 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.84510264 |
| 29 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.82133469 |
| 30 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.78975275 |
| 31 | P300_19829295_ChIP-Seq_ESCs_Human | 1.77492245 |
| 32 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.73820963 |
| 33 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.72579709 |
| 34 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.71694132 |
| 35 | VDR_22108803_ChIP-Seq_LS180_Human | 1.70537055 |
| 36 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.68296111 |
| 37 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.66861477 |
| 38 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.66687914 |
| 39 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.66112884 |
| 40 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.62865602 |
| 41 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.61729610 |
| 42 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.60846934 |
| 43 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.60798682 |
| 44 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.57152580 |
| 45 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.54397326 |
| 46 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.50893987 |
| 47 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.49910126 |
| 48 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.47618733 |
| 49 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.45761175 |
| 50 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.45739178 |
| 51 | * ER_23166858_ChIP-Seq_MCF-7_Human | 1.44852485 |
| 52 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.42919612 |
| 53 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.41251255 |
| 54 | * FUS_26573619_Chip-Seq_HEK293_Human | 1.40667194 |
| 55 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.36343349 |
| 56 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.33392693 |
| 57 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.31635210 |
| 58 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.28797390 |
| 59 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.25494007 |
| 60 | * PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.25358843 |
| 61 | STAT3_23295773_ChIP-Seq_U87_Human | 1.23680402 |
| 62 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.23518370 |
| 63 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.22323335 |
| 64 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.22181845 |
| 65 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.21353910 |
| 66 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.20639592 |
| 67 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.20508365 |
| 68 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.18785330 |
| 69 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.18365919 |
| 70 | AR_25329375_ChIP-Seq_VCAP_Human | 1.17652784 |
| 71 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.17126621 |
| 72 | TP53_16413492_ChIP-PET_HCT116_Human | 1.16396789 |
| 73 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.15358151 |
| 74 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 1.14902358 |
| 75 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.13560120 |
| 76 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.13514340 |
| 77 | * ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.12809028 |
| 78 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.11253079 |
| 79 | TCF4_23295773_ChIP-Seq_U87_Human | 1.11100236 |
| 80 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.10775135 |
| 81 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.10158424 |
| 82 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.09909147 |
| 83 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.09871666 |
| 84 | EWS_26573619_Chip-Seq_HEK293_Human | 1.08772979 |
| 85 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.08564769 |
| 86 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.08385257 |
| 87 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.07745012 |
| 88 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.07427363 |
| 89 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.07009979 |
| 90 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.06609158 |
| 91 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.05142013 |
| 92 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.04464878 |
| 93 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.04379043 |
| 94 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.03527897 |
| 95 | * BRD4_25478319_ChIP-Seq_HGPS_Human | 1.03396369 |
| 96 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.03276405 |
| 97 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.02973207 |
| 98 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.02561470 |
| 99 | SOX9_26525672_Chip-Seq_HEART_Mouse | 1.02071888 |
| 100 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.01659239 |
| 101 | JUN_21703547_ChIP-Seq_K562_Human | 1.01190240 |
| 102 | * MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.00809992 |
| 103 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 0.99580768 |
| 104 | * TAL1_26923725_Chip-Seq_HPCs_Mouse | 0.99322580 |
| 105 | * CJUN_26792858_Chip-Seq_BT549_Human | 0.99147944 |
| 106 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.97752166 |
| 107 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.97752166 |
| 108 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.96957570 |
| 109 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.96903854 |
| 110 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.96883190 |
| 111 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.96478828 |
| 112 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.96478828 |
| 113 | P300_18555785_Chip-Seq_ESCs_Mouse | 0.95804288 |
| 114 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 0.94453488 |
| 115 | KDM2B_26808549_Chip-Seq_REH_Human | 0.93962707 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003880_abnormal_central_pattern | 5.99337013 |
| 2 | MP0004859_abnormal_synaptic_plasticity | 4.89988334 |
| 3 | MP0004270_analgesia | 3.43521665 |
| 4 | MP0003635_abnormal_synaptic_transmissio | 3.29318952 |
| 5 | MP0000920_abnormal_myelination | 3.22375582 |
| 6 | MP0002064_seizures | 2.97145683 |
| 7 | MP0009745_abnormal_behavioral_response | 2.90417093 |
| 8 | MP0002272_abnormal_nervous_system | 2.74626217 |
| 9 | MP0005423_abnormal_somatic_nervous | 2.66870485 |
| 10 | MP0002063_abnormal_learning/memory/cond | 2.62403331 |
| 11 | MP0001486_abnormal_startle_reflex | 2.61627522 |
| 12 | MP0009046_muscle_twitch | 2.46385516 |
| 13 | MP0002572_abnormal_emotion/affect_behav | 2.42987512 |
| 14 | MP0000778_abnormal_nervous_system | 2.41348118 |
| 15 | MP0001529_abnormal_vocalization | 2.34616249 |
| 16 | MP0001440_abnormal_grooming_behavior | 2.21860868 |
| 17 | MP0001905_abnormal_dopamine_level | 2.12537174 |
| 18 | MP0003136_yellow_coat_color | 2.12388473 |
| 19 | MP0004742_abnormal_vestibular_system | 2.11740991 |
| 20 | MP0001968_abnormal_touch/_nociception | 2.09159996 |
| 21 | MP0004885_abnormal_endolymph | 2.05556921 |
| 22 | MP0002734_abnormal_mechanical_nocicepti | 2.03311061 |
| 23 | MP0003329_amyloid_beta_deposits | 2.01666308 |
| 24 | MP0004142_abnormal_muscle_tone | 1.99221481 |
| 25 | MP0002735_abnormal_chemical_nociception | 1.95764884 |
| 26 | MP0001501_abnormal_sleep_pattern | 1.91397882 |
| 27 | MP0005171_absent_coat_pigmentation | 1.90332545 |
| 28 | MP0003690_abnormal_glial_cell | 1.85424610 |
| 29 | MP0002736_abnormal_nociception_after | 1.84546304 |
| 30 | MP0000569_abnormal_digit_pigmentation | 1.75315601 |
| 31 | MP0002067_abnormal_sensory_capabilities | 1.72161408 |
| 32 | MP0005409_darkened_coat_color | 1.70409821 |
| 33 | MP0001970_abnormal_pain_threshold | 1.63434027 |
| 34 | MP0003634_abnormal_glial_cell | 1.61736219 |
| 35 | MP0001485_abnormal_pinna_reflex | 1.55745772 |
| 36 | MP0000955_abnormal_spinal_cord | 1.51871678 |
| 37 | MP0002184_abnormal_innervation | 1.49083365 |
| 38 | MP0002882_abnormal_neuron_morphology | 1.48779405 |
| 39 | MP0002733_abnormal_thermal_nociception | 1.44367180 |
| 40 | MP0005386_behavior/neurological_phenoty | 1.43498992 |
| 41 | MP0004924_abnormal_behavior | 1.43498992 |
| 42 | MP0001348_abnormal_lacrimal_gland | 1.42869726 |
| 43 | MP0005645_abnormal_hypothalamus_physiol | 1.42034867 |
| 44 | MP0008569_lethality_at_weaning | 1.42025825 |
| 45 | MP0008877_abnormal_DNA_methylation | 1.41349035 |
| 46 | MP0000579_abnormal_nail_morphology | 1.38728374 |
| 47 | MP0001188_hyperpigmentation | 1.38471642 |
| 48 | MP0002066_abnormal_motor_capabilities/c | 1.37598242 |
| 49 | MP0002557_abnormal_social/conspecific_i | 1.37014492 |
| 50 | MP0002229_neurodegeneration | 1.34728387 |
| 51 | MP0010678_abnormal_skin_adnexa | 1.30109375 |
| 52 | MP0010386_abnormal_urinary_bladder | 1.29164522 |
| 53 | MP0001346_abnormal_lacrimal_gland | 1.28239171 |
| 54 | MP0003632_abnormal_nervous_system | 1.28193827 |
| 55 | MP0001963_abnormal_hearing_physiology | 1.27764753 |
| 56 | MP0005551_abnormal_eye_electrophysiolog | 1.25725476 |
| 57 | MP0002877_abnormal_melanocyte_morpholog | 1.25548064 |
| 58 | MP0003631_nervous_system_phenotype | 1.25000987 |
| 59 | MP0006276_abnormal_autonomic_nervous | 1.24603216 |
| 60 | MP0002653_abnormal_ependyma_morphology | 1.24229316 |
| 61 | MP0009384_cardiac_valve_regurgitation | 1.20382040 |
| 62 | MP0003633_abnormal_nervous_system | 1.19633916 |
| 63 | MP0004147_increased_porphyrin_level | 1.19401839 |
| 64 | MP0004145_abnormal_muscle_electrophysio | 1.17988593 |
| 65 | MP0000013_abnormal_adipose_tissue | 1.15727471 |
| 66 | MP0005410_abnormal_fertilization | 1.12914368 |
| 67 | MP0001502_abnormal_circadian_rhythm | 1.12619934 |
| 68 | MP0005646_abnormal_pituitary_gland | 1.10460735 |
| 69 | MP0002752_abnormal_somatic_nervous | 1.09350795 |
| 70 | MP0002796_impaired_skin_barrier | 1.09092257 |
| 71 | MP0004811_abnormal_neuron_physiology | 1.07692141 |
| 72 | MP0004043_abnormal_pH_regulation | 1.06277445 |
| 73 | MP0005248_abnormal_Harderian_gland | 1.03258370 |
| 74 | MP0000383_abnormal_hair_follicle | 1.03177834 |
| 75 | MP0002152_abnormal_brain_morphology | 1.01926801 |
| 76 | MP0003938_abnormal_ear_development | 1.01142981 |
| 77 | MP0004381_abnormal_hair_follicle | 1.00923911 |
| 78 | MP0002822_catalepsy | 1.00477462 |
| 79 | MP0005623_abnormal_meninges_morphology | 1.00088223 |
| 80 | MP0002909_abnormal_adrenal_gland | 0.97554613 |
| 81 | MP0005499_abnormal_olfactory_system | 0.95410789 |
| 82 | MP0005394_taste/olfaction_phenotype | 0.95410789 |
| 83 | MP0003787_abnormal_imprinting | 0.95346935 |
| 84 | MP0000026_abnormal_inner_ear | 0.94511901 |
| 85 | MP0003950_abnormal_plasma_membrane | 0.93184297 |
| 86 | MP0009697_abnormal_copulation | 0.91740325 |
| 87 | MP0005379_endocrine/exocrine_gland_phen | 0.91362844 |
| 88 | MP0005167_abnormal_blood-brain_barrier | 0.89009525 |
| 89 | MP0000566_synostosis | 0.88828545 |
| 90 | MP0000427_abnormal_hair_cycle | 0.87335880 |
| 91 | MP0002332_abnormal_exercise_endurance | 0.86182918 |
| 92 | MP0001984_abnormal_olfaction | 0.85663295 |
| 93 | MP0001299_abnormal_eye_distance/ | 0.85497199 |
| 94 | MP0000604_amyloidosis | 0.83987277 |
| 95 | MP0009780_abnormal_chondrocyte_physiolo | 0.83129019 |
| 96 | MP0003890_abnormal_embryonic-extraembry | 0.82442923 |
| 97 | MP0001177_atelectasis | 0.81558296 |
| 98 | MP0000631_abnormal_neuroendocrine_gland | 0.77834471 |
| 99 | MP0004134_abnormal_chest_morphology | 0.76836213 |
| 100 | MP0005275_abnormal_skin_tensile | 0.76536458 |
| 101 | MP0006072_abnormal_retinal_apoptosis | 0.76022085 |
| 102 | MP0004858_abnormal_nervous_system | 0.75812396 |
| 103 | MP0002638_abnormal_pupillary_reflex | 0.75183759 |
| 104 | MP0008789_abnormal_olfactory_epithelium | 0.75026357 |
| 105 | MP0005195_abnormal_posterior_eye | 0.72752009 |
| 106 | MP0000462_abnormal_digestive_system | 0.71630123 |
| 107 | MP0002069_abnormal_eating/drinking_beha | 0.68665110 |
| 108 | MP0003091_abnormal_cell_migration | 0.68124163 |
| 109 | MP0003075_altered_response_to | 0.67871103 |
| 110 | MP0005501_abnormal_skin_physiology | 0.66620343 |
| 111 | MP0000516_abnormal_urinary_system | 0.66414285 |
| 112 | MP0005367_renal/urinary_system_phenotyp | 0.66414285 |
| 113 | MP0000762_abnormal_tongue_morphology | 0.66130681 |
| 114 | MP0010771_integument_phenotype | 0.63252356 |
| 115 | MP0001986_abnormal_taste_sensitivity | 0.63181427 |
| 116 | MP0001664_abnormal_digestion | 0.62704731 |
| 117 | MP0002876_abnormal_thyroid_physiology | 0.60623228 |
| 118 | MP0003879_abnormal_hair_cell | 0.59974846 |
| 119 | MP0003861_abnormal_nervous_system | 0.59623317 |
| 120 | MP0002090_abnormal_vision | 0.58560859 |
| 121 | MP0001943_abnormal_respiration | 0.58153322 |
| 122 | MP0000015_abnormal_ear_pigmentation | 0.57747377 |
| 123 | MP0002102_abnormal_ear_morphology | 0.55999434 |
| 124 | MP0001851_eye_inflammation | 0.54985491 |
| 125 | MP0008874_decreased_physiological_sensi | 0.54899635 |
| 126 | MP0009379_abnormal_foot_pigmentation | 0.54832935 |
| 127 | MP0004085_abnormal_heartbeat | 0.54471091 |
| 128 | MP0000639_abnormal_adrenal_gland | 0.53994218 |
| 129 | MP0005253_abnormal_eye_physiology | 0.52597723 |
| 130 | MP0000647_abnormal_sebaceous_gland | 0.52325429 |
| 131 | MP0005187_abnormal_penis_morphology | 0.51810698 |
| 132 | MP0000467_abnormal_esophagus_morphology | 0.51048644 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 5.51940055 |
| 2 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 5.51940055 |
| 3 | Focal motor seizures (HP:0011153) | 5.21870357 |
| 4 | Neurofibrillary tangles (HP:0002185) | 4.76556166 |
| 5 | Myokymia (HP:0002411) | 4.62801647 |
| 6 | Dysmetric saccades (HP:0000641) | 4.38386522 |
| 7 | Abnormality of the corticospinal tract (HP:0002492) | 4.35710576 |
| 8 | Cerebral inclusion bodies (HP:0100314) | 3.88188034 |
| 9 | Sensory axonal neuropathy (HP:0003390) | 3.79238970 |
| 10 | Dysmetria (HP:0001310) | 3.72811316 |
| 11 | Epileptic encephalopathy (HP:0200134) | 3.64947984 |
| 12 | Spastic gait (HP:0002064) | 3.64723995 |
| 13 | Parakeratosis (HP:0001036) | 3.61506907 |
| 14 | Supranuclear gaze palsy (HP:0000605) | 3.56712503 |
| 15 | Ankle clonus (HP:0011448) | 3.48396689 |
| 16 | Focal seizures (HP:0007359) | 3.43692920 |
| 17 | Postural tremor (HP:0002174) | 3.38002464 |
| 18 | Atonic seizures (HP:0010819) | 3.25351081 |
| 19 | Peripheral hypomyelination (HP:0007182) | 3.18133529 |
| 20 | Sensorimotor neuropathy (HP:0007141) | 3.16877185 |
| 21 | Impaired smooth pursuit (HP:0007772) | 3.13401412 |
| 22 | Insidious onset (HP:0003587) | 3.12560684 |
| 23 | Termporal pattern (HP:0011008) | 3.12560684 |
| 24 | Hyperventilation (HP:0002883) | 3.07769507 |
| 25 | Thickened helices (HP:0000391) | 3.06195782 |
| 26 | Broad-based gait (HP:0002136) | 3.04406429 |
| 27 | Retinal dysplasia (HP:0007973) | 3.01962587 |
| 28 | Difficulty running (HP:0009046) | 2.96591312 |
| 29 | Abnormality of saccadic eye movements (HP:0000570) | 2.92964342 |
| 30 | Intention tremor (HP:0002080) | 2.86930219 |
| 31 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.81765658 |
| 32 | Dyskinesia (HP:0100660) | 2.78311385 |
| 33 | Alacrima (HP:0000522) | 2.72448459 |
| 34 | Onion bulb formation (HP:0003383) | 2.71767424 |
| 35 | Scanning speech (HP:0002168) | 2.69999622 |
| 36 | Abnormal eating behavior (HP:0100738) | 2.67598649 |
| 37 | Postural instability (HP:0002172) | 2.63788220 |
| 38 | Impaired vibratory sensation (HP:0002495) | 2.62241091 |
| 39 | Neuronal loss in central nervous system (HP:0002529) | 2.61612071 |
| 40 | Increased circulating renin level (HP:0000848) | 2.61222220 |
| 41 | Drooling (HP:0002307) | 2.58733353 |
| 42 | Excessive salivation (HP:0003781) | 2.58733353 |
| 43 | Torticollis (HP:0000473) | 2.56380787 |
| 44 | Absent speech (HP:0001344) | 2.55468724 |
| 45 | Congenital sensorineural hearing impairment (HP:0008527) | 2.54050794 |
| 46 | Dialeptic seizures (HP:0011146) | 2.52989262 |
| 47 | Limb ataxia (HP:0002070) | 2.52515367 |
| 48 | Aplasia involving bones of the upper limbs (HP:0009823) | 2.47902299 |
| 49 | Aplasia of the phalanges of the hand (HP:0009802) | 2.47902299 |
| 50 | Aplasia involving bones of the extremities (HP:0009825) | 2.47902299 |
| 51 | Lower limb muscle weakness (HP:0007340) | 2.45957510 |
| 52 | Hypoplasia of the iris (HP:0007676) | 2.43459606 |
| 53 | Anteriorly placed anus (HP:0001545) | 2.42980401 |
| 54 | Cheilitis (HP:0100825) | 2.42150522 |
| 55 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.42126625 |
| 56 | Depression (HP:0000716) | 2.39875637 |
| 57 | Aqueductal stenosis (HP:0002410) | 2.38763987 |
| 58 | Action tremor (HP:0002345) | 2.38012722 |
| 59 | Dysdiadochokinesis (HP:0002075) | 2.36821594 |
| 60 | Progressive cerebellar ataxia (HP:0002073) | 2.34447029 |
| 61 | Clumsiness (HP:0002312) | 2.31869482 |
| 62 | Akinesia (HP:0002304) | 2.30818753 |
| 63 | Visual hallucinations (HP:0002367) | 2.28275963 |
| 64 | Pelvic girdle muscle weakness (HP:0003749) | 2.27997715 |
| 65 | Gaze-evoked nystagmus (HP:0000640) | 2.27883209 |
| 66 | Absence seizures (HP:0002121) | 2.26042081 |
| 67 | Abnormal auditory evoked potentials (HP:0006958) | 2.25521207 |
| 68 | Shoulder girdle muscle weakness (HP:0003547) | 2.24283330 |
| 69 | Split foot (HP:0001839) | 2.23248127 |
| 70 | Rigidity (HP:0002063) | 2.20315533 |
| 71 | Medial flaring of the eyebrow (HP:0010747) | 2.18491833 |
| 72 | Decreased lacrimation (HP:0000633) | 2.18299220 |
| 73 | Congenital malformation of the right heart (HP:0011723) | 2.18226665 |
| 74 | Double outlet right ventricle (HP:0001719) | 2.18226665 |
| 75 | Gait imbalance (HP:0002141) | 2.16721414 |
| 76 | Gait ataxia (HP:0002066) | 2.15286430 |
| 77 | Morphological abnormality of the pyramidal tract (HP:0002062) | 2.15153186 |
| 78 | Leukodystrophy (HP:0002415) | 2.14291553 |
| 79 | Decreased muscle mass (HP:0003199) | 2.13646787 |
| 80 | Slow saccadic eye movements (HP:0000514) | 2.13335721 |
| 81 | Truncal ataxia (HP:0002078) | 2.12575887 |
| 82 | Generalized tonic-clonic seizures (HP:0002069) | 2.10069254 |
| 83 | Vaginal atresia (HP:0000148) | 2.09538774 |
| 84 | Partial agenesis of the corpus callosum (HP:0001338) | 2.09315828 |
| 85 | Abnormality of nail color (HP:0100643) | 2.09047165 |
| 86 | Hemiparesis (HP:0001269) | 2.07720046 |
| 87 | Generalized myoclonic seizures (HP:0002123) | 2.07579879 |
| 88 | Urinary urgency (HP:0000012) | 2.06712716 |
| 89 | Abnormality of salivation (HP:0100755) | 2.06612602 |
| 90 | Abnormality of the hip-girdle musculature (HP:0001445) | 2.06402054 |
| 91 | Abnormality of the musculature of the pelvis (HP:0001469) | 2.06402054 |
| 92 | Type II lissencephaly (HP:0007260) | 2.04528699 |
| 93 | Megalencephaly (HP:0001355) | 2.02040305 |
| 94 | Poor eye contact (HP:0000817) | 2.00975914 |
| 95 | Genital tract atresia (HP:0001827) | 2.00936568 |
| 96 | Polyphagia (HP:0002591) | 2.00317925 |
| 97 | Epileptiform EEG discharges (HP:0011182) | 2.00213523 |
| 98 | Febrile seizures (HP:0002373) | 1.98908672 |
| 99 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.97646167 |
| 100 | Absent/shortened dynein arms (HP:0200106) | 1.97646167 |
| 101 | Impaired vibration sensation in the lower limbs (HP:0002166) | 1.97460767 |
| 102 | Heterochromia iridis (HP:0001100) | 1.97036606 |
| 103 | Amblyopia (HP:0000646) | 1.95937663 |
| 104 | Choreoathetosis (HP:0001266) | 1.94886629 |
| 105 | Choroideremia (HP:0001139) | 1.93605777 |
| 106 | Pheochromocytoma (HP:0002666) | 1.91793591 |
| 107 | Hyporeflexia of lower limbs (HP:0002600) | 1.91000594 |
| 108 | Congenital ichthyosiform erythroderma (HP:0007431) | 1.89606535 |
| 109 | Bradykinesia (HP:0002067) | 1.86964727 |
| 110 | Diplopia (HP:0000651) | 1.86421650 |
| 111 | Abnormality of binocular vision (HP:0011514) | 1.86421650 |
| 112 | Rapidly progressive (HP:0003678) | 1.85438455 |
| 113 | Oligodactyly (hands) (HP:0001180) | 1.85311131 |
| 114 | Bowel incontinence (HP:0002607) | 1.84899983 |
| 115 | Urinary bladder sphincter dysfunction (HP:0002839) | 1.84106404 |
| 116 | Metabolic alkalosis (HP:0200114) | 1.84016493 |
| 117 | Congenital primary aphakia (HP:0007707) | 1.83230110 |
| 118 | Mutism (HP:0002300) | 1.82820542 |
| 119 | Calf muscle hypertrophy (HP:0008981) | 1.82791453 |
| 120 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 1.81989726 |
| 121 | Widely spaced teeth (HP:0000687) | 1.81899308 |
| 122 | Difficulty climbing stairs (HP:0003551) | 1.81606215 |
| 123 | Cupped ear (HP:0000378) | 1.81544974 |
| 124 | Anxiety (HP:0000739) | 1.80771156 |
| 125 | Mitral stenosis (HP:0001718) | 1.79793496 |
| 126 | Tetraparesis (HP:0002273) | 1.79687157 |
| 127 | EEG with generalized epileptiform discharges (HP:0011198) | 1.78901907 |
| 128 | Conical tooth (HP:0000698) | 1.77792997 |
| 129 | Morphological abnormality of the inner ear (HP:0011390) | 1.76816863 |
| 130 | Cerebral hypomyelination (HP:0006808) | 1.76742008 |
| 131 | Autoamputation (HP:0001218) | 1.76629927 |
| 132 | Abnormal large intestine physiology (HP:0012700) | 1.76574964 |
| 133 | Blue irides (HP:0000635) | 1.76212104 |
| 134 | Abnormality of the antihelix (HP:0009738) | 1.75544556 |
| 135 | Nephrogenic diabetes insipidus (HP:0009806) | 1.75122377 |
| 136 | Increased serum pyruvate (HP:0003542) | 1.74397206 |
| 137 | Abnormality of glycolysis (HP:0004366) | 1.74397206 |
| 138 | Mixed hearing impairment (HP:0000410) | 1.73904909 |
| 139 | Acute necrotizing encephalopathy (HP:0006965) | 1.73652353 |
| 140 | Partial duplication of thumb phalanx (HP:0009944) | 1.73006633 |
| 141 | Absent septum pellucidum (HP:0001331) | 1.72439627 |
| 142 | White forelock (HP:0002211) | 1.71903759 |
| 143 | Limb dystonia (HP:0002451) | 1.71647312 |
| 144 | Focal dystonia (HP:0004373) | 1.71308597 |
| 145 | Diminished movement (HP:0002374) | 1.70866736 |
| 146 | Renal Fanconi syndrome (HP:0001994) | 1.70498411 |
| 147 | Clonus (HP:0002169) | 1.69263791 |
| 148 | Papilledema (HP:0001085) | 1.68158946 |
| 149 | Delusions (HP:0000746) | 1.67879056 |
| 150 | Gastroesophageal reflux (HP:0002020) | 1.67631180 |
| 151 | Synostosis involving the elbow (HP:0003938) | 1.65541314 |
| 152 | Humeroradial synostosis (HP:0003041) | 1.65541314 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHA4 | 3.83139904 |
| 2 | STK39 | 3.54694883 |
| 3 | CASK | 3.46693345 |
| 4 | NTRK3 | 3.44723572 |
| 5 | OXSR1 | 3.05647871 |
| 6 | SIK2 | 2.51970365 |
| 7 | TNIK | 2.50146365 |
| 8 | MAP3K9 | 2.21815867 |
| 9 | CDK19 | 2.18153536 |
| 10 | BCR | 2.10855923 |
| 11 | MARK1 | 2.00157978 |
| 12 | ARAF | 1.92465048 |
| 13 | PRPF4B | 1.86080247 |
| 14 | PNCK | 1.79127474 |
| 15 | FES | 1.76609154 |
| 16 | PKN1 | 1.70536709 |
| 17 | EPHB1 | 1.70301064 |
| 18 | MAP3K13 | 1.68305861 |
| 19 | TRPM7 | 1.65224219 |
| 20 | CAMK2B | 1.64444161 |
| 21 | MUSK | 1.61985007 |
| 22 | FGR | 1.54431082 |
| 23 | LATS2 | 1.52816642 |
| 24 | NTRK2 | 1.50421188 |
| 25 | MAPKAPK5 | 1.47104623 |
| 26 | DAPK2 | 1.42457366 |
| 27 | NEK6 | 1.40387607 |
| 28 | KSR2 | 1.36091714 |
| 29 | TYRO3 | 1.35861769 |
| 30 | WNK4 | 1.34919561 |
| 31 | UHMK1 | 1.33432473 |
| 32 | PLK2 | 1.32177247 |
| 33 | PTK2B | 1.31962516 |
| 34 | PAK6 | 1.28821932 |
| 35 | MINK1 | 1.26698735 |
| 36 | CAMK2A | 1.26121281 |
| 37 | CDK5 | 1.22889908 |
| 38 | PTK2 | 1.22322868 |
| 39 | SGK223 | 1.20769360 |
| 40 | SGK494 | 1.20769360 |
| 41 | PBK | 1.17824369 |
| 42 | FGFR2 | 1.17374916 |
| 43 | EPHA2 | 1.14381496 |
| 44 | CAMK2D | 1.14276873 |
| 45 | MAPK13 | 1.13130962 |
| 46 | PINK1 | 1.10853881 |
| 47 | NTRK1 | 1.06730441 |
| 48 | GRK7 | 1.04924213 |
| 49 | CAMKK2 | 1.04473458 |
| 50 | MAP3K12 | 1.03638369 |
| 51 | MAP3K4 | 1.02655285 |
| 52 | SGK2 | 1.01821449 |
| 53 | ROCK2 | 0.99081665 |
| 54 | MAP2K7 | 0.97767504 |
| 55 | CSNK1G2 | 0.96570863 |
| 56 | TNK2 | 0.96328976 |
| 57 | MARK2 | 0.94109008 |
| 58 | EIF2AK3 | 0.92118953 |
| 59 | PAK3 | 0.88615885 |
| 60 | CSNK1G3 | 0.87624319 |
| 61 | NME1 | 0.87199265 |
| 62 | ABL2 | 0.86923197 |
| 63 | MET | 0.86512980 |
| 64 | SGK3 | 0.85250004 |
| 65 | RIPK4 | 0.85160545 |
| 66 | GRK5 | 0.84430443 |
| 67 | CAMK2G | 0.83668245 |
| 68 | CSNK1A1L | 0.82626588 |
| 69 | CDK14 | 0.80964659 |
| 70 | LIMK1 | 0.80402146 |
| 71 | KSR1 | 0.80187521 |
| 72 | TAOK1 | 0.80172414 |
| 73 | BMPR2 | 0.79361150 |
| 74 | WNK1 | 0.79321206 |
| 75 | PRKCE | 0.78457165 |
| 76 | CDK18 | 0.76996257 |
| 77 | CDK15 | 0.76298878 |
| 78 | MST4 | 0.75882169 |
| 79 | CSNK1G1 | 0.75196186 |
| 80 | RAF1 | 0.73248593 |
| 81 | CAMKK1 | 0.73087882 |
| 82 | DYRK1A | 0.72904171 |
| 83 | PRKCQ | 0.68710529 |
| 84 | RPS6KA4 | 0.68504488 |
| 85 | DAPK3 | 0.68269590 |
| 86 | PHKG1 | 0.68116366 |
| 87 | PHKG2 | 0.68116366 |
| 88 | CDK11A | 0.67943390 |
| 89 | CLK1 | 0.67840887 |
| 90 | MAPK10 | 0.67287422 |
| 91 | FRK | 0.66175796 |
| 92 | PRKCG | 0.65319362 |
| 93 | STK38 | 0.65261583 |
| 94 | ADRBK1 | 0.63678128 |
| 95 | MAP3K2 | 0.62336868 |
| 96 | BRAF | 0.62171198 |
| 97 | CAMK1 | 0.59502106 |
| 98 | SGK1 | 0.59110853 |
| 99 | PRKD3 | 0.58105562 |
| 100 | MAP2K4 | 0.57873090 |
| 101 | DYRK2 | 0.56956227 |
| 102 | ADRBK2 | 0.56699630 |
| 103 | MAP3K1 | 0.56414813 |
| 104 | PIK3CA | 0.55936371 |
| 105 | FYN | 0.53154628 |
| 106 | MAPK15 | 0.52682107 |
| 107 | BMPR1B | 0.52559277 |
| 108 | DAPK1 | 0.51793290 |
| 109 | FER | 0.48270942 |
| 110 | CAMK1G | 0.48188782 |
| 111 | PDPK1 | 0.47744043 |
| 112 | MARK3 | 0.47587123 |
| 113 | PRKG1 | 0.47391402 |
| 114 | RPS6KA3 | 0.47341323 |
| 115 | MAPK7 | 0.46176507 |
| 116 | ICK | 0.46173908 |
| 117 | MOS | 0.45866598 |
| 118 | PRKCZ | 0.44996575 |
| 119 | STK11 | 0.43025779 |
| 120 | PDGFRB | 0.42166752 |
| 121 | FGFR1 | 0.42052485 |
| 122 | CAMK4 | 0.41405573 |
| 123 | AKT3 | 0.39900037 |
| 124 | DMPK | 0.39727387 |
| 125 | MYLK | 0.38358345 |
| 126 | TESK1 | 0.37900109 |
| 127 | PRKACA | 0.37486352 |
| 128 | PRKCA | 0.37323620 |
| 129 | MAPK12 | 0.36859937 |
| 130 | DDR2 | 0.36165387 |
| 131 | CSNK1A1 | 0.35511070 |
| 132 | MST1R | 0.34288846 |
| 133 | CDK3 | 0.34081287 |
| 134 | ROCK1 | 0.32868907 |
| 135 | LMTK2 | 0.32295204 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 3.48480502 |
| 2 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.78409961 |
| 3 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.61921967 |
| 4 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.58261091 |
| 5 | GABAergic synapse_Homo sapiens_hsa04727 | 2.36385058 |
| 6 | Circadian entrainment_Homo sapiens_hsa04713 | 2.33715871 |
| 7 | Fatty acid elongation_Homo sapiens_hsa00062 | 2.30572110 |
| 8 | Morphine addiction_Homo sapiens_hsa05032 | 2.17805302 |
| 9 | Long-term potentiation_Homo sapiens_hsa04720 | 2.11525315 |
| 10 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.03924011 |
| 11 | Serotonergic synapse_Homo sapiens_hsa04726 | 2.02653891 |
| 12 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.97993157 |
| 13 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.97672687 |
| 14 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.93508022 |
| 15 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.91569846 |
| 16 | Long-term depression_Homo sapiens_hsa04730 | 1.91479894 |
| 17 | Salivary secretion_Homo sapiens_hsa04970 | 1.87337802 |
| 18 | Axon guidance_Homo sapiens_hsa04360 | 1.86814272 |
| 19 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.85906089 |
| 20 | Olfactory transduction_Homo sapiens_hsa04740 | 1.81277719 |
| 21 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.79942595 |
| 22 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.71536898 |
| 23 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.70717690 |
| 24 | Taste transduction_Homo sapiens_hsa04742 | 1.63563436 |
| 25 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.51675778 |
| 26 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.45989606 |
| 27 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.43829738 |
| 28 | Cocaine addiction_Homo sapiens_hsa05030 | 1.41728780 |
| 29 | Renin secretion_Homo sapiens_hsa04924 | 1.41546965 |
| 30 | Alzheimers disease_Homo sapiens_hsa05010 | 1.41024941 |
| 31 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.33960821 |
| 32 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.26455023 |
| 33 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.26193551 |
| 34 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 1.25528478 |
| 35 | Insulin secretion_Homo sapiens_hsa04911 | 1.24416452 |
| 36 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.19868330 |
| 37 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.15914691 |
| 38 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.14262113 |
| 39 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.12941227 |
| 40 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.12031957 |
| 41 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 1.11716392 |
| 42 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 1.11378353 |
| 43 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.11280394 |
| 44 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.10725038 |
| 45 | Phototransduction_Homo sapiens_hsa04744 | 1.10561601 |
| 46 | Parkinsons disease_Homo sapiens_hsa05012 | 1.09515019 |
| 47 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.07150796 |
| 48 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.06842508 |
| 49 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.06838382 |
| 50 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.04566323 |
| 51 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.03662098 |
| 52 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.03479293 |
| 53 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.98573992 |
| 54 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.96550057 |
| 55 | Gap junction_Homo sapiens_hsa04540 | 0.95598110 |
| 56 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.91250903 |
| 57 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.89498684 |
| 58 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.87413177 |
| 59 | Melanoma_Homo sapiens_hsa05218 | 0.84461549 |
| 60 | Melanogenesis_Homo sapiens_hsa04916 | 0.83408731 |
| 61 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.82100459 |
| 62 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.81598802 |
| 63 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.79747295 |
| 64 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.78598356 |
| 65 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.78388678 |
| 66 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.78058842 |
| 67 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.77548227 |
| 68 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.77144085 |
| 69 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.76536452 |
| 70 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.75701181 |
| 71 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.74869839 |
| 72 | Huntingtons disease_Homo sapiens_hsa05016 | 0.71897174 |
| 73 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.71050593 |
| 74 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.70619722 |
| 75 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.70569811 |
| 76 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.70334143 |
| 77 | Salmonella infection_Homo sapiens_hsa05132 | 0.69729424 |
| 78 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.68882678 |
| 79 | Histidine metabolism_Homo sapiens_hsa00340 | 0.66510385 |
| 80 | Prion diseases_Homo sapiens_hsa05020 | 0.66158057 |
| 81 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.65803254 |
| 82 | Protein export_Homo sapiens_hsa03060 | 0.65602870 |
| 83 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.65137735 |
| 84 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.62567907 |
| 85 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.60927269 |
| 86 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.60244330 |
| 87 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.59973743 |
| 88 | Amoebiasis_Homo sapiens_hsa05146 | 0.59295044 |
| 89 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.56838459 |
| 90 | Adherens junction_Homo sapiens_hsa04520 | 0.56043897 |
| 91 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.55710560 |
| 92 | Glioma_Homo sapiens_hsa05214 | 0.54991608 |
| 93 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.53794668 |
| 94 | Lysosome_Homo sapiens_hsa04142 | 0.53721205 |
| 95 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.53520418 |
| 96 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.52900082 |
| 97 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.51304122 |
| 98 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.50772750 |
| 99 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.50693523 |
| 100 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.47531565 |
| 101 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.45154726 |
| 102 | Tight junction_Homo sapiens_hsa04530 | 0.44988393 |
| 103 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.44933412 |
| 104 | Endocytosis_Homo sapiens_hsa04144 | 0.44094320 |
| 105 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.43746630 |
| 106 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.43307554 |
| 107 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.42830276 |
| 108 | Alcoholism_Homo sapiens_hsa05034 | 0.42343917 |
| 109 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.41196163 |
| 110 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.40423454 |
| 111 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.40225561 |
| 112 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.39831936 |
| 113 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.38644999 |
| 114 | Circadian rhythm_Homo sapiens_hsa04710 | 0.37767451 |
| 115 | Bile secretion_Homo sapiens_hsa04976 | 0.37447618 |
| 116 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.36494878 |
| 117 | Mineral absorption_Homo sapiens_hsa04978 | 0.36184071 |
| 118 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.35171047 |
| 119 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.35065305 |
| 120 | Phagosome_Homo sapiens_hsa04145 | 0.34643580 |
| 121 | Bladder cancer_Homo sapiens_hsa05219 | 0.33805178 |
| 122 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.33349339 |
| 123 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.33146290 |
| 124 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.32949754 |
| 125 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.31402488 |
| 126 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.30416976 |

