KCTD5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.09428426
2Golgi transport vesicle coating (GO:0048200)5.09428426
3DNA unwinding involved in DNA replication (GO:0006268)4.36204541
4paraxial mesoderm development (GO:0048339)4.07984212
5protein localization to endosome (GO:0036010)4.06065889
6DNA replication-dependent nucleosome assembly (GO:0006335)3.97070095
7DNA replication-dependent nucleosome organization (GO:0034723)3.97070095
8regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.89577427
9protein localization to kinetochore (GO:0034501)3.87922570
10regulation of posttranscriptional gene silencing (GO:0060147)3.61292034
11regulation of gene silencing by miRNA (GO:0060964)3.61292034
12regulation of gene silencing by RNA (GO:0060966)3.61292034
13nuclear pore organization (GO:0006999)3.52892645
14mitotic nuclear envelope disassembly (GO:0007077)3.50823821
15peptidyl-arginine omega-N-methylation (GO:0035247)3.49988375
16pinocytosis (GO:0006907)3.44420247
17regulation of early endosome to late endosome transport (GO:2000641)3.44029544
18mitotic metaphase plate congression (GO:0007080)3.43803931
19formation of translation preinitiation complex (GO:0001731)3.43390637
20ribosome assembly (GO:0042255)3.37884310
21nuclear envelope disassembly (GO:0051081)3.37058412
22membrane disassembly (GO:0030397)3.37058412
23retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.30215088
24DNA replication initiation (GO:0006270)3.28621551
25heterochromatin organization (GO:0070828)3.25352385
26maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.23963282
27nuclear pore complex assembly (GO:0051292)3.22919960
28protein retention in ER lumen (GO:0006621)3.22413395
29positive regulation of Cdc42 GTPase activity (GO:0043089)3.20701497
30negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.19991563
31protein localization to chromosome, centromeric region (GO:0071459)3.16867452
32DNA strand elongation involved in DNA replication (GO:0006271)3.15903964
33regulation of hippo signaling (GO:0035330)3.13821143
34peptidyl-arginine methylation (GO:0018216)3.12650052
35peptidyl-arginine N-methylation (GO:0035246)3.12650052
36regulation of mammary gland epithelial cell proliferation (GO:0033599)3.11734542
37polarized epithelial cell differentiation (GO:0030859)3.11258848
38folic acid-containing compound biosynthetic process (GO:0009396)3.08474863
39maturation of SSU-rRNA (GO:0030490)3.05658184
40histone arginine methylation (GO:0034969)3.05534812
41barbed-end actin filament capping (GO:0051016)3.04181680
42negative regulation of chromosome segregation (GO:0051985)3.03260640
43NIK/NF-kappaB signaling (GO:0038061)2.99724057
44negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.98734790
45negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.97513571
46mitotic spindle assembly checkpoint (GO:0007094)2.97429806
47negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.97326256
48negative regulation of sister chromatid segregation (GO:0033046)2.97326256
49negative regulation of mitotic sister chromatid separation (GO:2000816)2.97326256
50negative regulation of mitotic sister chromatid segregation (GO:0033048)2.97326256
51regulation of sister chromatid cohesion (GO:0007063)2.96459841
52stress fiber assembly (GO:0043149)2.95624095
53pentose-phosphate shunt (GO:0006098)2.94758857
54DNA strand elongation (GO:0022616)2.94326308
55regulation of chromosome segregation (GO:0051983)2.93375595
56nucleobase biosynthetic process (GO:0046112)2.92949310
57mitotic spindle checkpoint (GO:0071174)2.92671710
58modulation by symbiont of host cellular process (GO:0044068)2.91395255
59regulation of spindle organization (GO:0090224)2.88667719
60spindle assembly checkpoint (GO:0071173)2.87825637
61proline biosynthetic process (GO:0006561)2.86914007
62skin morphogenesis (GO:0043589)2.86412265
63positive regulation of chromosome segregation (GO:0051984)2.85769779
64embryonic process involved in female pregnancy (GO:0060136)2.85266722
65response to peptidoglycan (GO:0032494)2.84468494
663-UTR-mediated mRNA stabilization (GO:0070935)2.84164140
67pre-miRNA processing (GO:0031054)2.83429659
68spindle checkpoint (GO:0031577)2.81747645
69activation of Rac GTPase activity (GO:0032863)2.79093272
70nuclear envelope organization (GO:0006998)2.78222166
71cellular protein complex localization (GO:0034629)2.77977847
72mitochondrial fusion (GO:0008053)2.77403220
73positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.77039946
74mitotic chromosome condensation (GO:0007076)2.76931695
75adherens junction assembly (GO:0034333)2.76043189
76mitotic sister chromatid segregation (GO:0000070)2.75761839
77lung-associated mesenchyme development (GO:0060484)2.75133618
78positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.75077370
79negative regulation of erythrocyte differentiation (GO:0045647)2.74911488
80cell-substrate adherens junction assembly (GO:0007045)2.74708627
81focal adhesion assembly (GO:0048041)2.74708627
82regulation of translational fidelity (GO:0006450)2.73891018
83translational initiation (GO:0006413)2.73406522
84spliceosomal snRNP assembly (GO:0000387)2.73195673
85sister chromatid segregation (GO:0000819)2.73057710
86apoptotic process involved in morphogenesis (GO:0060561)2.72562116
87regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.69702505
88regulation of mitotic metaphase/anaphase transition (GO:0030071)2.68911983
89metaphase plate congression (GO:0051310)2.68898261
90ribosome biogenesis (GO:0042254)2.68751931
91modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.68736876
92positive regulation by organism of defense response of other organism involved in symbiotic interact2.68736876
93modulation by symbiont of host immune response (GO:0052553)2.68736876
94positive regulation by symbiont of host defense response (GO:0052509)2.68736876
95modulation by symbiont of host defense response (GO:0052031)2.68736876
96modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.68736876
97purine nucleobase biosynthetic process (GO:0009113)2.67697566
98epithelial cell differentiation involved in prostate gland development (GO:0060742)2.67278676
99negative regulation of RNA splicing (GO:0033119)2.67194196
100glucose 6-phosphate metabolic process (GO:0051156)2.66978472
101DNA replication checkpoint (GO:0000076)2.66700254
102regulation of NFAT protein import into nucleus (GO:0051532)2.66157293
103protein complex localization (GO:0031503)2.65871405
104positive regulation of SMAD protein import into nucleus (GO:0060391)2.65849290
105chaperone mediated protein folding requiring cofactor (GO:0051085)2.64493115
106regulation of SMAD protein import into nucleus (GO:0060390)2.63882223
107hippo signaling (GO:0035329)2.63695215
108modulation by virus of host process (GO:0019054)2.63222647
109regulation of protein heterodimerization activity (GO:0043497)2.63203373
110regulation of mitotic spindle organization (GO:0060236)2.63053884
111positive regulation of nuclease activity (GO:0032075)2.62213845
112chaperone-mediated protein complex assembly (GO:0051131)2.61968518
113nuclear envelope reassembly (GO:0031468)2.61684484
114mitotic nuclear envelope reassembly (GO:0007084)2.61684484
115protein localization to chromosome (GO:0034502)2.61665508
116negative regulation of cell size (GO:0045792)2.61463392
117regulation of telomere maintenance via telomerase (GO:0032210)2.61291130
118activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.60864777
119mitotic G1 DNA damage checkpoint (GO:0031571)2.60298321
120viral transcription (GO:0019083)2.59460654
121positive regulation of keratinocyte differentiation (GO:0045618)2.58642378
122translational termination (GO:0006415)2.58360973
123chromatin assembly or disassembly (GO:0006333)2.55728575
124regulation of mitotic sister chromatid separation (GO:0010965)2.55582857
125regulation of mitotic sister chromatid segregation (GO:0033047)2.55582857
126regulation of sister chromatid segregation (GO:0033045)2.55582857
127regulation of superoxide anion generation (GO:0032928)2.55387289
128NADPH regeneration (GO:0006740)2.54671349
129peptidyl-lysine dimethylation (GO:0018027)2.54589639
130spliceosomal tri-snRNP complex assembly (GO:0000244)2.54163125
131cell-substrate junction assembly (GO:0007044)2.53573179
132maternal placenta development (GO:0001893)2.53416563
133regulation of translational termination (GO:0006449)2.53347544
134establishment of apical/basal cell polarity (GO:0035089)2.52280812
135regulation of centrosome cycle (GO:0046605)2.52154881
136negative regulation of mRNA processing (GO:0050686)2.51976172
137response to laminar fluid shear stress (GO:0034616)2.51353549
138anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.51205135
139IMP biosynthetic process (GO:0006188)2.48903058
140GDP-mannose metabolic process (GO:0019673)2.48815311
141endoplasmic reticulum unfolded protein response (GO:0030968)2.48313622
142regulation of type I interferon-mediated signaling pathway (GO:0060338)2.47464160
143regulation of glucose import in response to insulin stimulus (GO:2001273)2.47231200
144ribosomal large subunit biogenesis (GO:0042273)2.47190325
145regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.46042019
146translational elongation (GO:0006414)2.45348525
147DNA duplex unwinding (GO:0032508)2.45079552
148nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.44529254
149lipopolysaccharide-mediated signaling pathway (GO:0031663)2.43816963
150chromatin assembly (GO:0031497)2.43423499
151establishment of chromosome localization (GO:0051303)2.43344353
152DNA replication-independent nucleosome organization (GO:0034724)2.43327908
153DNA replication-independent nucleosome assembly (GO:0006336)2.43327908
154protein maturation by protein folding (GO:0022417)2.43095075
155DNA geometric change (GO:0032392)2.42961429
156regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.42330596
157ribonucleoprotein complex biogenesis (GO:0022613)2.42074860
158negative regulation of histone methylation (GO:0031061)2.41344014
159regulation of nuclease activity (GO:0032069)2.41331677
160histone H2A monoubiquitination (GO:0035518)2.41127423
161RNA stabilization (GO:0043489)2.41011871
162mRNA stabilization (GO:0048255)2.41011871
163negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.40966177
164cellular response to arsenic-containing substance (GO:0071243)2.40688728
165mRNA splicing, via spliceosome (GO:0000398)2.40143102
166glucose catabolic process (GO:0006007)2.38711683
167glycosphingolipid catabolic process (GO:0046479)2.37819347
168activation of MAPKKK activity (GO:0000185)2.36479378
169epithelial cell-cell adhesion (GO:0090136)2.36256978
170negative regulation of viral release from host cell (GO:1902187)2.35519142
171ER-nucleus signaling pathway (GO:0006984)2.35267897
172response to muramyl dipeptide (GO:0032495)2.34295512
173positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.34044349
174regulation of monocyte differentiation (GO:0045655)2.33639153
175modulation by virus of host morphology or physiology (GO:0019048)2.33136190
176cellular response to virus (GO:0098586)2.29686011
177regulation of defense response to virus by virus (GO:0050690)2.27914543
178hemidesmosome assembly (GO:0031581)2.27330317
179branching involved in mammary gland duct morphogenesis (GO:0060444)2.25436909
180cellular response to unfolded protein (GO:0034620)2.25178548
181regulation of nucleobase-containing compound transport (GO:0032239)2.24504307
182regulation of leukocyte degranulation (GO:0043300)2.23351261
183intracellular estrogen receptor signaling pathway (GO:0030520)2.22506259
184negative regulation of myeloid cell apoptotic process (GO:0033033)2.22091088
185regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.22011281
186trophectodermal cell differentiation (GO:0001829)2.20676432
187regulation of RNA export from nucleus (GO:0046831)2.19861436
188regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.19058222
189positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.19058222
190embryo implantation (GO:0007566)2.18061910
191endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.17706730
192vesicle coating (GO:0006901)2.15303529

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.93170230
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.27409450
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.95033208
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.30934277
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.03626453
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.89411994
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.75769268
8VDR_21846776_ChIP-Seq_THP-1_Human2.69122509
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.67703915
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.65848753
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.52828933
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.48523864
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.47069680
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.45506193
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.40426450
16XRN2_22483619_ChIP-Seq_HELA_Human2.35116611
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33333588
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.26102463
19AR_21909140_ChIP-Seq_LNCAP_Human2.21320576
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.13871400
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.02945205
22ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.02834005
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.02499154
24LXR_22292898_ChIP-Seq_THP-1_Human1.99897772
25* ETS1_20019798_ChIP-Seq_JURKAT_Human1.98317575
26NANOG_18555785_ChIP-Seq_MESCs_Mouse1.90642425
27KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.89144033
28* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.85567595
29TCF3_18692474_ChIP-Seq_MEFs_Mouse1.85152890
30RACK7_27058665_Chip-Seq_MCF-7_Human1.82219886
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.76429117
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75543744
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75469462
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.74712478
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73881370
36TCF7_22412390_ChIP-Seq_EML_Mouse1.72544249
37* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70827541
38* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.67648256
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.67338529
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.66951397
41* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.65978868
42MYC_22102868_ChIP-Seq_BL_Human1.64992876
43KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.62863257
44CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.62189786
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.61444420
46KLF4_18555785_ChIP-Seq_MESCs_Mouse1.61209534
47* TTF2_22483619_ChIP-Seq_HELA_Human1.58785802
48NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58004028
49SOX2_18555785_ChIP-Seq_MESCs_Mouse1.56828649
50VDR_24763502_ChIP-Seq_THP-1_Human1.55599226
51KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.55407086
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54630853
53TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.54472263
54KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.54367966
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.53935485
56* GABP_19822575_ChIP-Seq_HepG2_Human1.53745828
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.53343768
58KDM2B_26808549_Chip-Seq_DND41_Human1.50621928
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.48836646
60ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.48544461
61* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47815837
62* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.46568066
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46401261
64DCP1A_22483619_ChIP-Seq_HELA_Human1.42704031
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.42507883
66SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.41826261
67SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.40014259
68BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39063872
69CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.38149335
70ZNF263_19887448_ChIP-Seq_K562_Human1.36674937
71KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36307772
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36115640
73NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35949204
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.35447791
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.35447791
76KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.35447791
77* MAF_26560356_Chip-Seq_TH1_Human1.33684792
78TCF3_18692474_ChIP-Seq_MESCs_Mouse1.32667532
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.32482430
80HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31335827
81* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.29407402
82MYB_21317192_ChIP-Seq_ERMYB_Mouse1.28441408
83OCT4_18692474_ChIP-Seq_MEFs_Mouse1.28258278
84MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.27999216
85NANOG_21062744_ChIP-ChIP_HESCs_Human1.27261010
86SRY_22984422_ChIP-ChIP_TESTIS_Rat1.26831782
87SOX2_18692474_ChIP-Seq_MEFs_Mouse1.26674239
88* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26512978
89ATF3_27146783_Chip-Seq_COLON_Human1.26397948
90TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25964281
91* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25859709
92RUNX1_22412390_ChIP-Seq_EML_Mouse1.25214111
93* VDR_23849224_ChIP-Seq_CD4+_Human1.24719188
94P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24690227
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.24644219
96TET1_21451524_ChIP-Seq_MESCs_Mouse1.24079791
97CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23691448
98NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.23680947
99NCOR1_26117541_ChIP-Seq_K562_Human1.23358571
100RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22817040
101NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.22126794
102UTX_26944678_Chip-Seq_JUKART_Human1.21417109
103TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21145585
104SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21047471
105SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19467523
106TP63_19390658_ChIP-ChIP_HaCaT_Human1.19293798
107SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17911696
108KDM5A_27292631_Chip-Seq_BREAST_Human1.17420387
109EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.16830180
110CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16695706
111UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16652022
112* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15998100
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15735624
114STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15601651
115BP1_19119308_ChIP-ChIP_Hs578T_Human1.15058380
116ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15018616
117SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14077449
118GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13855879
119ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13727010
120ELK3_25401928_ChIP-Seq_HUVEC_Human1.13624200
121TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12637849
122SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12407903
123KDM2B_26808549_Chip-Seq_K562_Human1.12217875
124RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12200854
125MAF_26560356_Chip-Seq_TH2_Human1.11737859
126TFEB_21752829_ChIP-Seq_HELA_Human1.11644445
127TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11033296
128SALL1_21062744_ChIP-ChIP_HESCs_Human1.10959512
129PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10262230
130STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10218316
131NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08609366
132TRIM28_21343339_ChIP-Seq_HEK293_Human1.07794125
133NANOG_18692474_ChIP-Seq_MEFs_Mouse1.07656549
134* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.07160272
135E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06969832
136CLOCK_20551151_ChIP-Seq_293T_Human1.06858019
137TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06262530
138PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06067384
139* P68_20966046_ChIP-Seq_HELA_Human1.05252670
140SA1_27219007_Chip-Seq_ERYTHROID_Human1.04062411
141ELK1_22589737_ChIP-Seq_MCF10A_Human1.04060865
142SPI1_23547873_ChIP-Seq_NB4_Human1.03140552
143ESR2_21235772_ChIP-Seq_MCF-7_Human1.02520209
144* FOXP3_21729870_ChIP-Seq_TREG_Human1.02349993
145UBF1/2_26484160_Chip-Seq_HMECs_Human1.00761005
146SOX2_18692474_ChIP-Seq_MESCs_Mouse1.00229787
147CHD1_26751641_Chip-Seq_LNCaP_Human0.99989995
148KDM2B_26808549_Chip-Seq_JURKAT_Human0.99900152
149ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99159042
150TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98994819
151E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98531343
152NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.98500462
153NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98104461
154SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97763423
155* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.97285684
156* CIITA_25753668_ChIP-Seq_RAJI_Human0.97273151

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.47395497
2MP0002653_abnormal_ependyma_morphology3.45438174
3MP0003693_abnormal_embryo_hatching3.29234640
4MP0010030_abnormal_orbit_morphology3.14684024
5MP0004957_abnormal_blastocyst_morpholog3.13914986
6MP0003705_abnormal_hypodermis_morpholog2.95614083
7MP0010352_gastrointestinal_tract_polyps2.93748874
8MP0003111_abnormal_nucleus_morphology2.86104371
9MP0009840_abnormal_foam_cell2.73539407
10MP0005058_abnormal_lysosome_morphology2.71334673
11MP0002877_abnormal_melanocyte_morpholog2.69582575
12MP0000537_abnormal_urethra_morphology2.62159157
13MP0008260_abnormal_autophagy2.61168137
14MP0003077_abnormal_cell_cycle2.42765810
15MP0010094_abnormal_chromosome_stability2.32735350
16MP0005623_abnormal_meninges_morphology2.23589494
17MP0003303_peritoneal_inflammation2.23331040
18MP0008932_abnormal_embryonic_tissue2.22996491
19MP0001730_embryonic_growth_arrest2.17037488
20MP0008438_abnormal_cutaneous_collagen2.12570419
21MP0003191_abnormal_cellular_cholesterol2.05543563
22MP0003300_gastrointestinal_ulcer2.02896803
23MP0003453_abnormal_keratinocyte_physiol1.99987301
24MP0003436_decreased_susceptibility_to1.98567778
25MP0000350_abnormal_cell_proliferation1.91884907
26MP0008007_abnormal_cellular_replicative1.87887461
27MP0002085_abnormal_embryonic_tissue1.83515291
28MP0003123_paternal_imprinting1.83056437
29MP0002084_abnormal_developmental_patter1.80128606
30MP0003119_abnormal_digestive_system1.75890172
31MP0004947_skin_inflammation1.72426636
32MP0001849_ear_inflammation1.69514741
33MP0005076_abnormal_cell_differentiation1.67965517
34MP0004185_abnormal_adipocyte_glucose1.67665963
35MP0010234_abnormal_vibrissa_follicle1.67512605
36MP0003941_abnormal_skin_development1.63784226
37MP0001697_abnormal_embryo_size1.63760598
38MP0009333_abnormal_splenocyte_physiolog1.61013422
39MP0006054_spinal_hemorrhage1.60862778
40MP0000733_abnormal_muscle_development1.59296066
41MP0009053_abnormal_anal_canal1.57081216
42MP0001672_abnormal_embryogenesis/_devel1.56469417
43MP0005380_embryogenesis_phenotype1.56469417
44MP0003566_abnormal_cell_adhesion1.53982639
45MP0000428_abnormal_craniofacial_morphol1.53425265
46MP0004197_abnormal_fetal_growth/weight/1.52441362
47MP0000462_abnormal_digestive_system1.50608246
48MP0003937_abnormal_limbs/digits/tail_de1.50470449
49MP0005275_abnormal_skin_tensile1.49732775
50MP0003315_abnormal_perineum_morphology1.46117793
51MP0002080_prenatal_lethality1.42571768
52MP0003984_embryonic_growth_retardation1.37492603
53MP0004264_abnormal_extraembryonic_tissu1.37201083
54MP0002088_abnormal_embryonic_growth/wei1.36157065
55MP0001293_anophthalmia1.35370401
56MP0002282_abnormal_trachea_morphology1.34880863
57MP0002086_abnormal_extraembryonic_tissu1.33725677
58MP0010307_abnormal_tumor_latency1.33390510
59MP0000678_abnormal_parathyroid_gland1.31646606
60MP0003385_abnormal_body_wall1.30358810
61MP0002111_abnormal_tail_morphology1.28806331
62MP0004808_abnormal_hematopoietic_stem1.28435856
63MP0005023_abnormal_wound_healing1.27860990
64MP0001216_abnormal_epidermal_layer1.27533184
65MP0008058_abnormal_DNA_repair1.26821922
66MP0000490_abnormal_crypts_of1.23924537
67MP0003283_abnormal_digestive_organ1.21770077
68MP0005409_darkened_coat_color1.21268036
69MP0003861_abnormal_nervous_system1.19753652
70MP0002060_abnormal_skin_morphology1.19619821
71MP0002419_abnormal_innate_immunity1.19090238
72MP0003942_abnormal_urinary_system1.18468534
73MP0003448_altered_tumor_morphology1.18080671
74MP0003221_abnormal_cardiomyocyte_apopto1.17565920
75MP0004272_abnormal_basement_membrane1.15765514
76MP0002932_abnormal_joint_morphology1.14095898
77MP0003172_abnormal_lysosome_physiology1.11986004
78MP0009384_cardiac_valve_regurgitation1.11806861
79MP0005000_abnormal_immune_tolerance1.11475482
80MP0003567_abnormal_fetal_cardiomyocyte1.11361888
81MP0004133_heterotaxia1.11149095
82MP0005025_abnormal_response_to1.10446259
83MP0005621_abnormal_cell_physiology1.10197815
84MP0003755_abnormal_palate_morphology1.09916914
85MP0002396_abnormal_hematopoietic_system1.09453596
86MP0003115_abnormal_respiratory_system1.08153515
87MP0000049_abnormal_middle_ear1.08065806
88MP0000432_abnormal_head_morphology1.06926029
89MP0003718_maternal_effect1.06728083
90MP0001727_abnormal_embryo_implantation1.06459554
91MP0005397_hematopoietic_system_phenotyp1.06349899
92MP0001545_abnormal_hematopoietic_system1.06349899
93MP0003329_amyloid_beta_deposits1.05599773
94MP0003091_abnormal_cell_migration1.05353667
95MP0000685_abnormal_immune_system1.05200259
96MP0002092_abnormal_eye_morphology1.04552404
97MP0008057_abnormal_DNA_replication1.04477663
98MP0000534_abnormal_ureter_morphology1.02838343
99MP0002697_abnormal_eye_size1.02545686
100MP0003279_aneurysm1.01733923
101MP0002998_abnormal_bone_remodeling1.00920938
102MP0002751_abnormal_autonomic_nervous1.00895809
103MP0002452_abnormal_antigen_presenting1.00702915
104MP0005508_abnormal_skeleton_morphology1.00304140
105MP0003890_abnormal_embryonic-extraembry0.99574792
106MP0003878_abnormal_ear_physiology0.99347571
107MP0005377_hearing/vestibular/ear_phenot0.99347571
108MP0004233_abnormal_muscle_weight0.99065280
109MP0005501_abnormal_skin_physiology0.98758087
110MP0005464_abnormal_platelet_physiology0.98535025
111MP0003935_abnormal_craniofacial_develop0.96885903
112MP0003828_pulmonary_edema0.96309743
113MP0000343_altered_response_to0.96149088
114MP0005257_abnormal_intraocular_pressure0.95896177
115MP0002116_abnormal_craniofacial_bone0.95735819
116MP0009250_abnormal_appendicular_skeleto0.95480769
117MP0002148_abnormal_hypersensitivity_rea0.95369745
118MP0001853_heart_inflammation0.95294582
119MP0001299_abnormal_eye_distance/0.94678514
120MP0003763_abnormal_thymus_physiology0.93439555
121MP0004858_abnormal_nervous_system0.92816149
122MP0003121_genomic_imprinting0.92387629
123MP0001915_intracranial_hemorrhage0.91898865
124MP0002398_abnormal_bone_marrow0.91631244
125MP0009785_altered_susceptibility_to0.90324196
126MP0002420_abnormal_adaptive_immunity0.89901804
127MP0001819_abnormal_immune_cell0.89680480
128MP0009931_abnormal_skin_appearance0.89596144
129MP0000313_abnormal_cell_death0.89166898
130MP0001835_abnormal_antigen_presentation0.89054671
131MP0002114_abnormal_axial_skeleton0.87734433
132MP0002723_abnormal_immune_serum0.87135931
133MP0003786_premature_aging0.87075231
134MP0010155_abnormal_intestine_physiology0.86911563
135MP0000477_abnormal_intestine_morphology0.86848089
136MP0000750_abnormal_muscle_regeneration0.86684550
137MP0002089_abnormal_postnatal_growth/wei0.85484830
138MP0001958_emphysema0.85466981
139MP0005384_cellular_phenotype0.84297126
140MP0005666_abnormal_adipose_tissue0.84144324
141MP0008789_abnormal_olfactory_epithelium0.83222705
142MP0001286_abnormal_eye_development0.82932009
143MP0002233_abnormal_nose_morphology0.82777884
144MP0000377_abnormal_hair_follicle0.82704712
145MP0002429_abnormal_blood_cell0.82545552
146MP0002098_abnormal_vibrissa_morphology0.82355882
147MP0000604_amyloidosis0.81609845
148MP0003075_altered_response_to0.81452016
149MP0002796_impaired_skin_barrier0.81021305
150MP0009278_abnormal_bone_marrow0.80857571
151MP0001533_abnormal_skeleton_physiology0.80717972
152MP0002722_abnormal_immune_system0.79939748
153MP0003938_abnormal_ear_development0.79085675
154MP0000716_abnormal_immune_system0.78964484
155MP0002210_abnormal_sex_determination0.78691746
156MP0000747_muscle_weakness0.76084117
157MP0000858_altered_metastatic_potential0.75810497
158MP0002019_abnormal_tumor_incidence0.75521807
159MP0000467_abnormal_esophagus_morphology0.75467320
160MP0002925_abnormal_cardiovascular_devel0.74540004

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)3.85579563
2Protrusio acetabuli (HP:0003179)3.66025311
3Selective tooth agenesis (HP:0001592)3.50051300
4Breast hypoplasia (HP:0003187)3.27153649
5Vertebral compression fractures (HP:0002953)3.14865258
6Hyperacusis (HP:0010780)3.09213911
7Shallow orbits (HP:0000586)3.06484484
8Achilles tendon contracture (HP:0001771)2.85724528
9Abnormality of liposaccharide metabolism (HP:0010968)2.84588798
10Abnormality of glycosphingolipid metabolism (HP:0004343)2.84588798
11Abnormality of glycolipid metabolism (HP:0010969)2.84588798
12Distal lower limb amyotrophy (HP:0008944)2.67423470
13Ependymoma (HP:0002888)2.64851993
14Cellulitis (HP:0100658)2.62436296
15Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.62287109
16Short 4th metacarpal (HP:0010044)2.62287109
17Colon cancer (HP:0003003)2.61168653
18Trismus (HP:0000211)2.60098048
19Long palpebral fissure (HP:0000637)2.49861126
20Genu recurvatum (HP:0002816)2.48637515
21Abnormality of the Achilles tendon (HP:0005109)2.46959045
22Birth length less than 3rd percentile (HP:0003561)2.41595690
23Patellar aplasia (HP:0006443)2.40984753
24Abnormality of macrophages (HP:0004311)2.40645968
25Ankle contracture (HP:0006466)2.40549295
26Abnormality of the anterior horn cell (HP:0006802)2.39427613
27Degeneration of anterior horn cells (HP:0002398)2.39427613
28Distal lower limb muscle weakness (HP:0009053)2.39388229
29Aplasia/hypoplasia of the humerus (HP:0006507)2.38608162
30Eczematoid dermatitis (HP:0000976)2.37645731
31Aplasia/Hypoplasia of the patella (HP:0006498)2.33927960
32Abnormality of the calcaneus (HP:0008364)2.33428303
33Astrocytoma (HP:0009592)2.33351024
34Abnormality of the astrocytes (HP:0100707)2.33351024
35Centrally nucleated skeletal muscle fibers (HP:0003687)2.32321623
36Flat acetabular roof (HP:0003180)2.32017180
37Wrist flexion contracture (HP:0001239)2.30419313
38Fibular aplasia (HP:0002990)2.30142419
39Cholecystitis (HP:0001082)2.29195616
40Abnormal gallbladder physiology (HP:0012438)2.29195616
41Thin bony cortex (HP:0002753)2.26565221
42Progressive muscle weakness (HP:0003323)2.24712691
43Abdominal situs inversus (HP:0003363)2.24472873
44Abnormality of abdominal situs (HP:0011620)2.24472873
45Ragged-red muscle fibers (HP:0003200)2.22898853
46Short humerus (HP:0005792)2.20281886
47Increased connective tissue (HP:0009025)2.19926230
48Shoulder girdle muscle weakness (HP:0003547)2.18582038
49Rib fusion (HP:0000902)2.17452550
50Pelvic girdle muscle weakness (HP:0003749)2.16455032
51Insomnia (HP:0100785)2.15968356
52Carpal bone hypoplasia (HP:0001498)2.15562312
53Neoplasm of the pancreas (HP:0002894)2.14723216
54Abnormality of the distal phalanges of the toes (HP:0010182)2.13598747
55Abnormality of dentin (HP:0010299)2.12581521
56Calcaneovalgus deformity (HP:0001848)2.11014452
57Loss of speech (HP:0002371)2.10335059
58Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.09994624
59Absent forearm bone (HP:0003953)2.09808655
60Aplasia involving forearm bones (HP:0009822)2.09808655
61Increased cerebral lipofuscin (HP:0011813)2.09503526
62Facial hemangioma (HP:0000329)2.09207724
63Absent radius (HP:0003974)2.07116074
64Abnormality of the 4th metacarpal (HP:0010012)2.06801471
65Axonal loss (HP:0003447)2.06634819
66Deviation of the thumb (HP:0009603)2.06202078
67Fatigue (HP:0012378)2.05134112
68Short nail (HP:0001799)2.03108376
69Atrophic scars (HP:0001075)2.03089665
70Pterygium (HP:0001059)2.02831364
71Bladder diverticulum (HP:0000015)2.02643251
72Proximal placement of thumb (HP:0009623)2.02472263
73Soft skin (HP:0000977)2.02355278
74Missing ribs (HP:0000921)2.00850568
75Medulloblastoma (HP:0002885)1.98894707
76Hyperparathyroidism (HP:0000843)1.98343927
77Atrophy/Degeneration involving motor neurons (HP:0007373)1.97133029
78Dilatation of the ascending aorta (HP:0005111)1.96950601
79Cerebral hypomyelination (HP:0006808)1.94050637
80High anterior hairline (HP:0009890)1.92905698
81Abnormality of the labia minora (HP:0012880)1.92863497
82Bone pain (HP:0002653)1.92592651
83Rough bone trabeculation (HP:0100670)1.91980066
84Abnormality of nail color (HP:0100643)1.90773039
85Recurrent abscess formation (HP:0002722)1.90678265
86Neuronal loss in central nervous system (HP:0002529)1.89830199
87Segmental peripheral demyelination/remyelination (HP:0003481)1.89820608
88Renal duplication (HP:0000075)1.88940182
89Deformed tarsal bones (HP:0008119)1.88764699
90Disproportionate tall stature (HP:0001519)1.88359665
91Hypertensive crisis (HP:0100735)1.88351380
92Upper motor neuron abnormality (HP:0002127)1.88180748
93Bowel diverticulosis (HP:0005222)1.87956599
94Fused cervical vertebrae (HP:0002949)1.87300223
95Slender long bone (HP:0003100)1.86946678
96Cerebral aneurysm (HP:0004944)1.86404570
97Myopathic facies (HP:0002058)1.86338798
98Tongue fasciculations (HP:0001308)1.86305564
99Broad face (HP:0000283)1.85908226
100Abnormality of the hip-girdle musculature (HP:0001445)1.85838411
101Abnormality of the musculature of the pelvis (HP:0001469)1.85838411
102Cerebral inclusion bodies (HP:0100314)1.85836408
103Fragile skin (HP:0001030)1.85690541
104Muscle fibrillation (HP:0010546)1.84933852
105Esophageal atresia (HP:0002032)1.82023281
106Glioma (HP:0009733)1.81907217
107Breech presentation (HP:0001623)1.81874448
108Difficulty climbing stairs (HP:0003551)1.81845800
109Atresia of the external auditory canal (HP:0000413)1.81583011
110Malignant gastrointestinal tract tumors (HP:0006749)1.81385635
111Gastrointestinal carcinoma (HP:0002672)1.81385635
112Aortic dissection (HP:0002647)1.81135960
113Abnormality of the thoracic spine (HP:0100711)1.80190683
114Diminished motivation (HP:0000745)1.78172551
115Biliary tract neoplasm (HP:0100574)1.77949427
116Abnormality of the umbilical cord (HP:0010881)1.77730718
117Dysostosis multiplex (HP:0000943)1.77327422
118Recurrent bacterial skin infections (HP:0005406)1.77270358
119Hand muscle atrophy (HP:0009130)1.77112325
120Apathy (HP:0000741)1.76783091
121Overlapping toe (HP:0001845)1.76403548
122Abnormal trabecular bone morphology (HP:0100671)1.75634255
123Progressive external ophthalmoplegia (HP:0000590)1.74387031
124Neurofibrillary tangles (HP:0002185)1.74015631
125Osteolytic defects of the phalanges of the hand (HP:0009771)1.73778640
126Osteolytic defects of the hand bones (HP:0009699)1.73778640
127Increased nuchal translucency (HP:0010880)1.73745181
128Syringomyelia (HP:0003396)1.72271071
129Spinal cord lesions (HP:0100561)1.72271071
130Myocardial infarction (HP:0001658)1.71385168
131Short phalanx of the thumb (HP:0009660)1.70834162
132Upper limb amyotrophy (HP:0009129)1.70625974
133Distal upper limb amyotrophy (HP:0007149)1.70625974
134Generalized amyotrophy (HP:0003700)1.70481218
135Micronodular cirrhosis (HP:0001413)1.70246422
136Overriding aorta (HP:0002623)1.70045106
137Abnormality of skeletal muscle fiber size (HP:0012084)1.69957486
138Increased density of long bones (HP:0006392)1.69843111
139Glossoptosis (HP:0000162)1.69582390
140Elbow flexion contracture (HP:0002987)1.68740519
141Back pain (HP:0003418)1.68314236
142Abnormality of the distal phalanx of the thumb (HP:0009617)1.68300773
143Blue sclerae (HP:0000592)1.67717987
144Increased variability in muscle fiber diameter (HP:0003557)1.66428209
145Asymmetry of the thorax (HP:0001555)1.66095488
146Spinal rigidity (HP:0003306)1.65449283
147Angiofibromas (HP:0010615)1.64920957
148Adenoma sebaceum (HP:0009720)1.64920957
149Interstitial pulmonary disease (HP:0006530)1.64726613
150Megalocornea (HP:0000485)1.63308183
151Hemivertebrae (HP:0002937)1.62169921
152Abnormality of the proximal phalanges of the hand (HP:0009834)1.62137089
153Multiple enchondromatosis (HP:0005701)1.61671346
154Coronal craniosynostosis (HP:0004440)1.61307388
155Recurrent viral infections (HP:0004429)1.60906743
156Microvesicular hepatic steatosis (HP:0001414)1.60054413
157Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.59971948
158Thoracic kyphosis (HP:0002942)1.59757243
159Aplasia/Hypoplasia of the sternum (HP:0006714)1.57928838
160Increased IgE level (HP:0003212)1.57815234
161Deviation of the hallux (HP:0010051)1.57795749
162Lower limb amyotrophy (HP:0007210)1.57719796
163Hemorrhage of the eye (HP:0011885)1.57702542
164Gingivitis (HP:0000230)1.57365161
165Ulnar bowing (HP:0003031)1.57308799
166Obstructive lung disease (HP:0006536)1.57283901
167Chronic obstructive pulmonary disease (HP:0006510)1.57283901
168Reticulocytosis (HP:0001923)1.57047575
169Ankyloglossia (HP:0010296)1.56839499
170Neoplasm of the oral cavity (HP:0100649)1.56808200
171Vertebral fusion (HP:0002948)1.56696933
172Abnormal umbilical cord blood vessels (HP:0011403)1.56617052
173Single umbilical artery (HP:0001195)1.56617052
174Abnormality of the fetal cardiovascular system (HP:0010948)1.56617052
175Patellar dislocation (HP:0002999)1.56568742
176Malnutrition (HP:0004395)1.56384197
177Deep venous thrombosis (HP:0002625)1.56275604
178Nail dystrophy (HP:0008404)1.55774444
179Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.55592372
180Short 1st metacarpal (HP:0010034)1.55592372
181Abnormality of the 1st metacarpal (HP:0010009)1.55250889
182Oligodactyly (HP:0012165)1.55166916
183Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.54571760
184Abnormal number of incisors (HP:0011064)1.54320501
185Rhabdomyosarcoma (HP:0002859)1.54183798

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA23.77765084
2BUB13.70967552
3IRAK33.63286125
4TESK23.00020249
5SMG12.96267288
6PRPF4B2.89522383
7ERN12.84943122
8CDC72.63320200
9WEE12.61084525
10TESK12.45513899
11LATS22.44469660
12LIMK12.44133682
13NEK22.28411935
14NEK12.09210979
15ARAF2.06535319
16EEF2K2.04616424
17TRIB31.95707562
18RPS6KB21.92554255
19TTK1.91435135
20SIK11.87566720
21PAK41.84337502
22MAP3K101.78988342
23EPHB21.67587637
24EIF2AK11.67513810
25MAP3K81.67442143
26DYRK31.58768929
27STK101.57752539
28CDK121.55560521
29MAP2K31.55237528
30SCYL21.54351151
31MAP3K131.53328592
32MST1R1.50222603
33RIPK11.49547217
34DDR21.47801304
35RPS6KA41.41940044
36DYRK21.40339428
37PLK11.36895723
38AURKA1.36265284
39ACVR1B1.35216403
40EPHB11.33282462
41PIM21.25654274
42SRPK11.24976781
43CDK71.24218300
44TYRO31.21044957
45LRRK21.18569669
46MAP3K31.18566224
47PKN21.17688071
48IRAK41.16707381
49PDGFRA1.16520639
50TBK11.15398016
51PASK1.14528026
52AURKB1.13398024
53LATS11.13378953
54BRAF1.11018477
55TTN1.10519776
56KSR11.09619862
57MAP3K141.09151475
58FGFR41.08380457
59PAK11.07694779
60TAOK11.07439040
61NME21.06962006
62CHEK21.05823065
63MET1.04396189
64TLK11.03686757
65PAK21.02922070
66KSR21.01226219
67MAP3K10.99826550
68MAPKAPK30.99630061
69PTK60.97787721
70MAP4K10.96019753
71TSSK60.94342769
72MKNK10.91589343
73STK30.91279246
74PRKCI0.90045514
75MOS0.88512173
76MARK10.88127397
77PTK20.87246201
78ILK0.86089150
79FGFR10.85902402
80STK38L0.85891027
81CHEK10.83969323
82TYK20.83647888
83ATR0.83542030
84ICK0.82089177
85RAF10.81801676
86MAP2K20.81618398
87BRSK20.81467687
88LMTK20.79272761
89CDK140.79129742
90SIK30.77426100
91IRAK20.76967452
92CLK10.76948548
93CDK40.76668201
94PLK30.76546600
95TGFBR10.75546737
96RIPK40.75066011
97BRSK10.74557047
98MTOR0.74434135
99PLK40.73071469
100ALK0.71830244
101CDK150.70370068
102CDK60.69558255
103PRKD20.69434699
104CDC42BPA0.68208423
105CDK11A0.67742897
106CDK180.66941885
107MAP3K90.65273706
108EIF2AK30.64766809
109NEK90.63932307
110PDPK10.63690800
111ZAP700.62169279
112RPS6KA20.60827469
113CDK20.60327831
114ERBB30.59100989
115CDK90.59049079
116BMX0.57986961
117CSK0.57604008
118PBK0.57377840
119MAPK110.56750899
120BRD40.56210724
121PAK30.55197900
122JAK30.54813423
123MELK0.53754907
124AKT20.50767321
125CSF1R0.49898586
126CSNK1G30.49804963
127PRKG20.49753436
128FER0.49558963
129ERBB20.48847747
130ERBB40.48120507
131BCR0.47447676
132DYRK1B0.47358188
133MAP3K110.46974986
134CDK10.45924377
135RPS6KC10.45172241
136RPS6KL10.45172241
137MST40.45136382
138ABL20.44004831
139MAP2K10.43957607
140CSNK1A1L0.43928117
141BLK0.43403714
142ROCK20.41953073
143CSNK1E0.41676070
144TAOK20.41597540
145KDR0.40547328
146TGFBR20.40524266
147MAPKAPK20.39952952
148PAK60.39830721
149FGR0.38077318
150NTRK10.37922103
151CDK80.36593608
152MAP3K50.35661627

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.16744987
2RNA transport_Homo sapiens_hsa030132.88351118
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.86465900
4Spliceosome_Homo sapiens_hsa030402.83548370
5Cell cycle_Homo sapiens_hsa041102.79846140
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.70252826
7Mismatch repair_Homo sapiens_hsa034302.61738512
8Proteasome_Homo sapiens_hsa030502.32154088
9Ribosome_Homo sapiens_hsa030102.15676314
10Base excision repair_Homo sapiens_hsa034102.06806585
11p53 signaling pathway_Homo sapiens_hsa041152.04038538
12Other glycan degradation_Homo sapiens_hsa005112.03657190
13Acute myeloid leukemia_Homo sapiens_hsa052211.98595507
14Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.97237441
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.97131921
16RNA polymerase_Homo sapiens_hsa030201.96872064
17Hippo signaling pathway_Homo sapiens_hsa043901.94494187
18Nucleotide excision repair_Homo sapiens_hsa034201.92848873
19mRNA surveillance pathway_Homo sapiens_hsa030151.88176891
20Basal cell carcinoma_Homo sapiens_hsa052171.73242577
21B cell receptor signaling pathway_Homo sapiens_hsa046621.67477813
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.64873420
23Bladder cancer_Homo sapiens_hsa052191.59695131
24Homologous recombination_Homo sapiens_hsa034401.56015601
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.50874300
26Hedgehog signaling pathway_Homo sapiens_hsa043401.50838579
27Fructose and mannose metabolism_Homo sapiens_hsa000511.47357589
28One carbon pool by folate_Homo sapiens_hsa006701.45868181
29Basal transcription factors_Homo sapiens_hsa030221.45393470
30MicroRNAs in cancer_Homo sapiens_hsa052061.45110022
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.44883674
32Oocyte meiosis_Homo sapiens_hsa041141.41342457
33Osteoclast differentiation_Homo sapiens_hsa043801.37689145
34Pyrimidine metabolism_Homo sapiens_hsa002401.37578165
35Shigellosis_Homo sapiens_hsa051311.36646795
36Tight junction_Homo sapiens_hsa045301.36090272
37Small cell lung cancer_Homo sapiens_hsa052221.35705874
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.33363247
39Leishmaniasis_Homo sapiens_hsa051401.32055129
40Influenza A_Homo sapiens_hsa051641.31963553
41Adherens junction_Homo sapiens_hsa045201.31798873
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.30017963
43Lysosome_Homo sapiens_hsa041421.29102553
44Prion diseases_Homo sapiens_hsa050201.28388252
45Viral carcinogenesis_Homo sapiens_hsa052031.24793460
46TGF-beta signaling pathway_Homo sapiens_hsa043501.24292744
47Hepatitis C_Homo sapiens_hsa051601.23008677
48RNA degradation_Homo sapiens_hsa030181.18899606
49Galactose metabolism_Homo sapiens_hsa000521.18141343
50Epstein-Barr virus infection_Homo sapiens_hsa051691.16331288
51Colorectal cancer_Homo sapiens_hsa052101.14071243
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.10242843
53TNF signaling pathway_Homo sapiens_hsa046681.09875496
54Toxoplasmosis_Homo sapiens_hsa051451.09833305
55Proteoglycans in cancer_Homo sapiens_hsa052051.08815100
56Chronic myeloid leukemia_Homo sapiens_hsa052201.08559366
57Vibrio cholerae infection_Homo sapiens_hsa051101.07700727
58NF-kappa B signaling pathway_Homo sapiens_hsa040641.06506350
59Tuberculosis_Homo sapiens_hsa051521.06209814
60HTLV-I infection_Homo sapiens_hsa051661.05271271
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01916346
62Fanconi anemia pathway_Homo sapiens_hsa034600.99273657
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98167793
64Renin-angiotensin system_Homo sapiens_hsa046140.95285966
65Thyroid cancer_Homo sapiens_hsa052160.95127893
66Measles_Homo sapiens_hsa051620.94747635
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92722167
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92381653
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91498790
70Notch signaling pathway_Homo sapiens_hsa043300.91327515
71ErbB signaling pathway_Homo sapiens_hsa040120.86912210
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86817751
73ECM-receptor interaction_Homo sapiens_hsa045120.84349342
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83432989
75Systemic lupus erythematosus_Homo sapiens_hsa053220.83210560
76Wnt signaling pathway_Homo sapiens_hsa043100.83080677
77Phagosome_Homo sapiens_hsa041450.82888447
78Focal adhesion_Homo sapiens_hsa045100.82050473
79Prolactin signaling pathway_Homo sapiens_hsa049170.80878089
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.79947170
81Renal cell carcinoma_Homo sapiens_hsa052110.79520898
82Insulin signaling pathway_Homo sapiens_hsa049100.78525309
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76379429
84Endometrial cancer_Homo sapiens_hsa052130.76232585
85Pathways in cancer_Homo sapiens_hsa052000.76130750
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75217752
87Apoptosis_Homo sapiens_hsa042100.74584006
88Viral myocarditis_Homo sapiens_hsa054160.72977125
89Axon guidance_Homo sapiens_hsa043600.72177724
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.72168484
91Melanoma_Homo sapiens_hsa052180.70943345
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70744655
93Non-homologous end-joining_Homo sapiens_hsa034500.67384385
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67238394
95Pancreatic cancer_Homo sapiens_hsa052120.66994161
96mTOR signaling pathway_Homo sapiens_hsa041500.66324590
97T cell receptor signaling pathway_Homo sapiens_hsa046600.64950793
98Pertussis_Homo sapiens_hsa051330.64360264
99Carbon metabolism_Homo sapiens_hsa012000.64143763
100VEGF signaling pathway_Homo sapiens_hsa043700.63835677
101Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62843145
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62158209
103Pentose phosphate pathway_Homo sapiens_hsa000300.61139931
104Alcoholism_Homo sapiens_hsa050340.60003578
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58775235
106Malaria_Homo sapiens_hsa051440.57750221
107Antigen processing and presentation_Homo sapiens_hsa046120.57401389
108Endocytosis_Homo sapiens_hsa041440.57052127
109Purine metabolism_Homo sapiens_hsa002300.56700203
110Prostate cancer_Homo sapiens_hsa052150.55469135
111Chemokine signaling pathway_Homo sapiens_hsa040620.54607572
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.54280896
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53916973
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53278127
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.53244099
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53214446
117Salmonella infection_Homo sapiens_hsa051320.53193998
118Inositol phosphate metabolism_Homo sapiens_hsa005620.52790124
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51849594
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51365424
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49909628
122HIF-1 signaling pathway_Homo sapiens_hsa040660.49569734
123N-Glycan biosynthesis_Homo sapiens_hsa005100.49405549
124Glioma_Homo sapiens_hsa052140.49044055
125Gap junction_Homo sapiens_hsa045400.48918364
126AMPK signaling pathway_Homo sapiens_hsa041520.48239013
127Biosynthesis of amino acids_Homo sapiens_hsa012300.48119010
128NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47154884
129Melanogenesis_Homo sapiens_hsa049160.44226024
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43544950
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42738220
132Mineral absorption_Homo sapiens_hsa049780.42489452
133Herpes simplex infection_Homo sapiens_hsa051680.40864226
134Amoebiasis_Homo sapiens_hsa051460.40591277
135Hepatitis B_Homo sapiens_hsa051610.40219786
136Non-small cell lung cancer_Homo sapiens_hsa052230.39914878
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.39379880
138Rap1 signaling pathway_Homo sapiens_hsa040150.39154886
139Sulfur relay system_Homo sapiens_hsa041220.36185684
140Legionellosis_Homo sapiens_hsa051340.34673481
141Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33746855
142Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33344478
143Glutathione metabolism_Homo sapiens_hsa004800.31952350

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