KCTD6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glutamate secretion (GO:0014047)5.51958888
2synaptic vesicle exocytosis (GO:0016079)5.51699127
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.44926250
4neuronal action potential propagation (GO:0019227)5.40750107
5vocalization behavior (GO:0071625)5.36761024
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.28141407
7locomotory exploration behavior (GO:0035641)4.93744019
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.88201745
9regulation of synaptic vesicle exocytosis (GO:2000300)4.82524118
10positive regulation of synapse maturation (GO:0090129)4.80722534
11neurotransmitter secretion (GO:0007269)4.70715663
12regulation of glutamate receptor signaling pathway (GO:1900449)4.65806515
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.64767249
14neurotransmitter-gated ion channel clustering (GO:0072578)4.50321687
15synaptic vesicle maturation (GO:0016188)4.50241355
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.47952763
17regulation of synaptic vesicle transport (GO:1902803)4.44946613
18neuron cell-cell adhesion (GO:0007158)4.44070252
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.37945952
20protein localization to synapse (GO:0035418)4.35565124
21synaptic vesicle docking involved in exocytosis (GO:0016081)4.35243278
22proline transport (GO:0015824)4.24722702
23glutamate receptor signaling pathway (GO:0007215)4.12736393
24synaptic transmission, glutamatergic (GO:0035249)4.11386673
25negative regulation of synaptic transmission, GABAergic (GO:0032229)4.05752975
26gamma-aminobutyric acid transport (GO:0015812)4.03515030
27regulation of neuronal synaptic plasticity (GO:0048168)4.03351192
28exploration behavior (GO:0035640)4.01143509
29neuron-neuron synaptic transmission (GO:0007270)3.98397324
30regulation of long-term neuronal synaptic plasticity (GO:0048169)3.93905951
31water-soluble vitamin biosynthetic process (GO:0042364)3.91532523
32gamma-aminobutyric acid signaling pathway (GO:0007214)3.88989299
33protein localization to cilium (GO:0061512)3.87377402
34regulation of excitatory postsynaptic membrane potential (GO:0060079)3.75715755
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.73794931
36respiratory chain complex IV assembly (GO:0008535)3.71279373
37neurotransmitter transport (GO:0006836)3.70975470
38long-term memory (GO:0007616)3.70379422
39regulation of synapse maturation (GO:0090128)3.70296508
40response to pheromone (GO:0019236)3.63424315
41negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.61501468
42cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.58049965
43DNA double-strand break processing (GO:0000729)3.58035270
44regulation of postsynaptic membrane potential (GO:0060078)3.57172883
45synaptic vesicle endocytosis (GO:0048488)3.56774415
46protein complex biogenesis (GO:0070271)3.55183759
47cell migration in hindbrain (GO:0021535)3.53942183
48cytochrome complex assembly (GO:0017004)3.53924746
49regulation of synaptic plasticity (GO:0048167)3.53716766
50negative regulation of dendrite morphogenesis (GO:0050774)3.52049286
51long-term synaptic potentiation (GO:0060291)3.51603495
52regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.50796313
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.49532766
54regulation of neurotransmitter levels (GO:0001505)3.49105638
55response to histamine (GO:0034776)3.47450687
56cell communication by electrical coupling (GO:0010644)3.46731419
57neuron recognition (GO:0008038)3.41805548
58positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.39595727
59negative regulation of transcription regulatory region DNA binding (GO:2000678)3.39295004
60transmission of nerve impulse (GO:0019226)3.36263530
61innervation (GO:0060384)3.35651879
62serotonin receptor signaling pathway (GO:0007210)3.33910692
63regulation of neurotransmitter secretion (GO:0046928)3.33475799
64layer formation in cerebral cortex (GO:0021819)3.33240798
65serotonin metabolic process (GO:0042428)3.32545665
66positive regulation of membrane potential (GO:0045838)3.28556973
67mitochondrial respiratory chain complex assembly (GO:0033108)3.26784324
68behavioral response to nicotine (GO:0035095)3.25615290
69signal complex assembly (GO:0007172)3.25408985
70regulation of synaptic transmission, glutamatergic (GO:0051966)3.23417037
71pyrimidine nucleobase catabolic process (GO:0006208)3.22772838
72cornea development in camera-type eye (GO:0061303)3.21578022
73regulation of synapse structural plasticity (GO:0051823)3.21322723
74G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.18299773
75G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.18115448
76regulation of vesicle fusion (GO:0031338)3.15120136
77replication fork processing (GO:0031297)3.13556528
78neural tube formation (GO:0001841)3.13200044
79establishment of protein localization to mitochondrial membrane (GO:0090151)3.12860100
80negative regulation of DNA-dependent DNA replication (GO:2000104)3.12450967
81regulation of neurotransmitter transport (GO:0051588)3.09344205
82detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.08613349
83striatum development (GO:0021756)3.08190446
84nonmotile primary cilium assembly (GO:0035058)3.07260403
85transferrin transport (GO:0033572)3.06574422
86presynaptic membrane assembly (GO:0097105)3.05030999
87behavioral defense response (GO:0002209)3.04941460
88behavioral fear response (GO:0001662)3.04941460
89cellular potassium ion homeostasis (GO:0030007)3.04471633
90synaptic vesicle transport (GO:0048489)3.03086078
91establishment of synaptic vesicle localization (GO:0097480)3.03086078
92platelet dense granule organization (GO:0060155)3.02985344
93intraciliary transport (GO:0042073)3.02686248
94cerebellar Purkinje cell differentiation (GO:0021702)3.00458410
95primary amino compound metabolic process (GO:1901160)3.00375776
96synaptic transmission (GO:0007268)2.99830209
97membrane depolarization (GO:0051899)2.99509829
98negative regulation of dendrite development (GO:2000171)2.99151962
99energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.99016627
100ATP hydrolysis coupled proton transport (GO:0015991)2.99016627
101neuromuscular process controlling balance (GO:0050885)2.99014001
102synapse assembly (GO:0007416)2.98774908
103behavioral response to cocaine (GO:0048148)2.97777120
104positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.97675400
105inositol phosphate catabolic process (GO:0071545)2.97599527
106cullin deneddylation (GO:0010388)2.97084317
107NADH dehydrogenase complex assembly (GO:0010257)2.96927785
108mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.96927785
109mitochondrial respiratory chain complex I assembly (GO:0032981)2.96927785
110protein-cofactor linkage (GO:0018065)2.96305831
111regulation of synaptic transmission (GO:0050804)2.95570440
112neuromuscular process (GO:0050905)2.93585122
113regulation of dendritic spine morphogenesis (GO:0061001)2.92854090
114learning (GO:0007612)2.92712914
115C4-dicarboxylate transport (GO:0015740)2.92507198
116reciprocal DNA recombination (GO:0035825)2.92163655
117reciprocal meiotic recombination (GO:0007131)2.92163655
118somite development (GO:0061053)2.91955234
119auditory behavior (GO:0031223)2.90207635
120membrane depolarization during action potential (GO:0086010)2.85943626
121mannosylation (GO:0097502)2.85904983
122response to auditory stimulus (GO:0010996)2.85283493
123preassembly of GPI anchor in ER membrane (GO:0016254)2.85025970
124axonal fasciculation (GO:0007413)2.84769455
125recombinational repair (GO:0000725)2.84114939
126chromatin remodeling at centromere (GO:0031055)2.83428552
127positive regulation of dendritic spine morphogenesis (GO:0061003)2.83149748
128calcium-mediated signaling using intracellular calcium source (GO:0035584)2.82966068
129neuromuscular synaptic transmission (GO:0007274)2.82590004
130regulation of cilium movement (GO:0003352)2.81621055
131ferric iron transport (GO:0015682)2.81470683
132trivalent inorganic cation transport (GO:0072512)2.81470683
133neuromuscular process controlling posture (GO:0050884)2.80756563
134limb bud formation (GO:0060174)2.80750784
135fear response (GO:0042596)2.80587866
136double-strand break repair via homologous recombination (GO:0000724)2.80121813
137nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.79359295
138cerebellar granule cell differentiation (GO:0021707)2.79109646
139mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.78745038
140exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.77416761
141protein K6-linked ubiquitination (GO:0085020)2.77314064
142epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.76794620
143mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.75779194
144energy coupled proton transport, down electrochemical gradient (GO:0015985)2.74158159
145ATP synthesis coupled proton transport (GO:0015986)2.74158159
146retinal cone cell development (GO:0046549)2.73730257
147lactate metabolic process (GO:0006089)2.69608256
148nucleobase catabolic process (GO:0046113)2.69128388
149RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.68727732
150regulation of glucokinase activity (GO:0033131)2.68409094
151regulation of hexokinase activity (GO:1903299)2.68409094
152protein neddylation (GO:0045116)2.68229640
153epithelial cilium movement (GO:0003351)2.68177884
154cilium morphogenesis (GO:0060271)2.67902937
155presynaptic membrane organization (GO:0097090)2.67227594
156centriole replication (GO:0007099)2.65958332
157regulation of timing of cell differentiation (GO:0048505)2.65934690
158protein polyglutamylation (GO:0018095)2.64126387
159GPI anchor metabolic process (GO:0006505)2.63981519
160fucose catabolic process (GO:0019317)2.63124157
161L-fucose metabolic process (GO:0042354)2.63124157
162L-fucose catabolic process (GO:0042355)2.63124157
163CENP-A containing nucleosome assembly (GO:0034080)2.62288178
164tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.61933490
165RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.61933490
166regulation of meiosis I (GO:0060631)2.61139237
167protein deneddylation (GO:0000338)2.60938166
168axoneme assembly (GO:0035082)2.58170179
169ubiquinone biosynthetic process (GO:0006744)2.57970765
170detection of light stimulus involved in sensory perception (GO:0050962)2.57184929
171detection of light stimulus involved in visual perception (GO:0050908)2.57184929
172synapsis (GO:0007129)2.56350961
173cilium organization (GO:0044782)2.54854741
174ubiquinone metabolic process (GO:0006743)2.52858685
175adaptation of signaling pathway (GO:0023058)2.52608936
176behavioral response to ethanol (GO:0048149)2.52260302
177somatic hypermutation of immunoglobulin genes (GO:0016446)2.51477026
178somatic diversification of immune receptors via somatic mutation (GO:0002566)2.51477026
179cilium assembly (GO:0042384)2.51276856
180termination of RNA polymerase III transcription (GO:0006386)2.50364197
181transcription elongation from RNA polymerase III promoter (GO:0006385)2.50364197
182regulation of nuclear cell cycle DNA replication (GO:0033262)2.46520735
183regulation of collateral sprouting (GO:0048670)2.46149422
184inner ear receptor stereocilium organization (GO:0060122)2.45333712
185piRNA metabolic process (GO:0034587)2.43899493
186neuron fate determination (GO:0048664)2.43830369
187photoreceptor cell maintenance (GO:0045494)2.43563663
188regulation of development, heterochronic (GO:0040034)2.43172512
189proteasome assembly (GO:0043248)2.43139887
190phosphorylated carbohydrate dephosphorylation (GO:0046838)2.42302755
191inositol phosphate dephosphorylation (GO:0046855)2.42302755
192positive regulation of mitochondrial fission (GO:0090141)2.42148439
193maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.39926057
194histone exchange (GO:0043486)2.38692212
195S-adenosylmethionine metabolic process (GO:0046500)2.37926814
196negative regulation of telomere maintenance (GO:0032205)2.37646013
197photoreceptor cell development (GO:0042461)2.34058824

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.26574927
2GBX2_23144817_ChIP-Seq_PC3_Human3.79790173
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95322078
4VDR_22108803_ChIP-Seq_LS180_Human2.81529095
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.75259678
6REST_21632747_ChIP-Seq_MESCs_Mouse2.75126363
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.75075345
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.74094372
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.63298194
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.56858364
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.43818600
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.43384676
13TAF15_26573619_Chip-Seq_HEK293_Human2.41601455
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.39385949
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37550106
16EWS_26573619_Chip-Seq_HEK293_Human2.35983393
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.35844226
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.33374745
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.33183505
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.30886426
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.29358673
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25855962
23EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25855962
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.23094495
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.22263011
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17653506
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.16693312
28CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15179806
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.14633390
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.13110328
31MTF2_20144788_ChIP-Seq_MESCs_Mouse2.12859973
32RNF2_27304074_Chip-Seq_ESCs_Mouse2.01825469
33ERG_21242973_ChIP-ChIP_JURKAT_Human2.01594068
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98938269
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.94360564
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90701062
37SMAD4_21799915_ChIP-Seq_A2780_Human1.89850530
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.88773054
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81738917
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.80432921
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79212248
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.78666186
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.78393727
44ELK1_19687146_ChIP-ChIP_HELA_Human1.76438480
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.75591982
46DROSHA_22980978_ChIP-Seq_HELA_Human1.75539840
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75377240
48P300_19829295_ChIP-Seq_ESCs_Human1.71362748
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.64531391
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.60386968
51MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.60369866
52AR_21572438_ChIP-Seq_LNCaP_Human1.58686310
53SUZ12_27294783_Chip-Seq_ESCs_Mouse1.56573715
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56501531
55ER_23166858_ChIP-Seq_MCF-7_Human1.55592726
56MYC_18940864_ChIP-ChIP_HL60_Human1.54714569
57RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.54199082
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51562039
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51099873
60IRF1_19129219_ChIP-ChIP_H3396_Human1.50624960
61AR_25329375_ChIP-Seq_VCAP_Human1.50424589
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.49605514
63* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49007723
64VDR_23849224_ChIP-Seq_CD4+_Human1.45542019
65FUS_26573619_Chip-Seq_HEK293_Human1.44038477
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43543373
67SOX2_21211035_ChIP-Seq_LN229_Gbm1.42328933
68CBP_20019798_ChIP-Seq_JUKART_Human1.42285039
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42285039
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41880449
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.38705365
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38155976
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37378149
74* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36134649
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35095330
76TP53_22573176_ChIP-Seq_HFKS_Human1.34382707
77BCAT_22108803_ChIP-Seq_LS180_Human1.34329973
78SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.33574391
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33514667
80SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.33309906
81STAT3_23295773_ChIP-Seq_U87_Human1.32988428
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.31138845
83* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.30432980
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.30278581
85* SOX2_19829295_ChIP-Seq_ESCs_Human1.30144694
86* NANOG_19829295_ChIP-Seq_ESCs_Human1.30144694
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29102066
88E2F4_17652178_ChIP-ChIP_JURKAT_Human1.28582743
89RNF2_27304074_Chip-Seq_NSC_Mouse1.28438294
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26408514
91KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25947575
92AR_19668381_ChIP-Seq_PC3_Human1.25100484
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24228631
94BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24070098
95CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23947925
96NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.23869549
97RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23601410
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23199830
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22879657
100RXR_22108803_ChIP-Seq_LS180_Human1.22312703
101* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21822720
102NANOG_18555785_Chip-Seq_ESCs_Mouse1.21208763
103NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.19930685
104TCF4_22108803_ChIP-Seq_LS180_Human1.19549821
105ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18880154
106SMAD3_21741376_ChIP-Seq_EPCs_Human1.18552722
107PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17914914
108RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17424309
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17324379
110PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17060508
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16899419
112YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16145780
113TCF4_23295773_ChIP-Seq_U87_Human1.15555001
114ETS1_20019798_ChIP-Seq_JURKAT_Human1.15221233
115FOXP3_21729870_ChIP-Seq_TREG_Human1.14188769
116POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14043564
117AHR_22903824_ChIP-Seq_MCF-7_Human1.13642327
118SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12798285
119ARNT_22903824_ChIP-Seq_MCF-7_Human1.12473785
120ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11672864
121SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.10652303
122EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10627077
123NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10124679
124PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09915741
125SMAD_19615063_ChIP-ChIP_OVARY_Human1.09313650
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09047225
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09047225
128CRX_20693478_ChIP-Seq_RETINA_Mouse1.08862695
129KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08546872
130FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08487409
131NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08399189
132TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07889289
133FOXA1_25329375_ChIP-Seq_VCAP_Human1.07749023
134FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07749023
135RING1B_27294783_Chip-Seq_NPCs_Mouse1.07581781
136STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07521656
137SMAD4_21741376_ChIP-Seq_EPCs_Human1.07140051
138P53_22387025_ChIP-Seq_ESCs_Mouse1.04955522
139CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04790722
140JUN_21703547_ChIP-Seq_K562_Human1.04705434
141TP53_16413492_ChIP-PET_HCT116_Human1.04139664
142CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03637519
143IGF1R_20145208_ChIP-Seq_DFB_Human1.03065499
144RUNX2_22187159_ChIP-Seq_PCA_Human1.02661435
145CBX2_27304074_Chip-Seq_ESCs_Mouse1.02405973
146PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02309765
147* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01826903
148RING1B_27294783_Chip-Seq_ESCs_Mouse1.01085812
149JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.01054102
150TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00893525
151FLI1_21867929_ChIP-Seq_TH2_Mouse1.00593468
152SRF_21415370_ChIP-Seq_HL-1_Mouse1.00333315
153FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99993373
154ZNF274_21170338_ChIP-Seq_K562_Hela0.99980799
155ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99135430
156TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99007009
157PRDM14_20953172_ChIP-Seq_ESCs_Human0.98471543
158* NCOR_22424771_ChIP-Seq_293T_Human0.98178826
159TP53_18474530_ChIP-ChIP_U2OS_Human0.97892449
160WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95404181

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.99988833
2MP0003880_abnormal_central_pattern4.72541082
3MP0003635_abnormal_synaptic_transmissio3.88079307
4MP0004270_analgesia3.32493784
5MP0002063_abnormal_learning/memory/cond3.21511178
6MP0009745_abnormal_behavioral_response3.20681192
7MP0008877_abnormal_DNA_methylation3.14567907
8MP0009046_muscle_twitch3.03780767
9MP0002735_abnormal_chemical_nociception2.96674496
10MP0002064_seizures2.93958174
11MP0001968_abnormal_touch/_nociception2.82771516
12MP0002572_abnormal_emotion/affect_behav2.78654104
13MP0001501_abnormal_sleep_pattern2.76984378
14MP0002938_white_spotting2.39974169
15MP0002734_abnormal_mechanical_nocicepti2.39862270
16MP0002272_abnormal_nervous_system2.38824269
17MP0002102_abnormal_ear_morphology2.35048865
18MP0004858_abnormal_nervous_system2.28247814
19MP0003329_amyloid_beta_deposits2.27877532
20MP0001486_abnormal_startle_reflex2.27043901
21MP0002736_abnormal_nociception_after2.25118553
22MP0002163_abnormal_gland_morphology2.23531654
23MP0003183_abnormal_peptide_metabolism2.22322107
24MP0003195_calcinosis2.18277223
25MP0002733_abnormal_thermal_nociception2.15262247
26MP0006072_abnormal_retinal_apoptosis2.14962425
27MP0002822_catalepsy2.07950202
28MP0002067_abnormal_sensory_capabilities1.94347293
29MP0002184_abnormal_innervation1.94220840
30MP0001440_abnormal_grooming_behavior1.93710462
31MP0001970_abnormal_pain_threshold1.91699977
32MP0000372_irregular_coat_pigmentation1.88608127
33MP0000778_abnormal_nervous_system1.83357212
34MP0002909_abnormal_adrenal_gland1.82186828
35MP0005253_abnormal_eye_physiology1.81535730
36MP0008789_abnormal_olfactory_epithelium1.79696119
37MP0005379_endocrine/exocrine_gland_phen1.78596790
38MP0000566_synostosis1.75790616
39MP0003121_genomic_imprinting1.75504049
40MP0004133_heterotaxia1.74024274
41MP0008058_abnormal_DNA_repair1.70836975
42MP0000569_abnormal_digit_pigmentation1.70574030
43MP0005646_abnormal_pituitary_gland1.69894342
44MP0005423_abnormal_somatic_nervous1.68194600
45MP0006276_abnormal_autonomic_nervous1.64438163
46MP0001188_hyperpigmentation1.63042003
47MP0002557_abnormal_social/conspecific_i1.57963138
48MP0009780_abnormal_chondrocyte_physiolo1.57596712
49MP0004924_abnormal_behavior1.57203298
50MP0005386_behavior/neurological_phenoty1.57203298
51MP0000631_abnormal_neuroendocrine_gland1.56318488
52MP0003879_abnormal_hair_cell1.56085403
53MP0001905_abnormal_dopamine_level1.53852926
54MP0003011_delayed_dark_adaptation1.53411953
55MP0004147_increased_porphyrin_level1.51503552
56MP0002234_abnormal_pharynx_morphology1.49839576
57MP0003787_abnormal_imprinting1.46688260
58MP0004811_abnormal_neuron_physiology1.46107958
59MP0010386_abnormal_urinary_bladder1.43815325
60MP0000955_abnormal_spinal_cord1.43001386
61MP0003283_abnormal_digestive_organ1.42462963
62MP0001984_abnormal_olfaction1.40539414
63MP0001293_anophthalmia1.39915702
64MP0008569_lethality_at_weaning1.35625002
65MP0003718_maternal_effect1.35313178
66MP0005084_abnormal_gallbladder_morpholo1.35005124
67MP0003890_abnormal_embryonic-extraembry1.33538464
68MP0002066_abnormal_motor_capabilities/c1.32420312
69MP0002882_abnormal_neuron_morphology1.31049075
70MP0003937_abnormal_limbs/digits/tail_de1.29322408
71MP0005075_abnormal_melanosome_morpholog1.28886331
72MP0000427_abnormal_hair_cycle1.28153621
73MP0005367_renal/urinary_system_phenotyp1.27904800
74MP0000516_abnormal_urinary_system1.27904800
75MP0003136_yellow_coat_color1.25874631
76MP0000647_abnormal_sebaceous_gland1.24066979
77MP0010094_abnormal_chromosome_stability1.19764283
78MP0004885_abnormal_endolymph1.17177774
79MP0003631_nervous_system_phenotype1.13039084
80MP0003633_abnormal_nervous_system1.12868777
81MP0002876_abnormal_thyroid_physiology1.12432279
82MP0000604_amyloidosis1.11885347
83MP0001502_abnormal_circadian_rhythm1.10680349
84MP0002229_neurodegeneration1.08887734
85MP0009697_abnormal_copulation1.06706707
86MP0003123_paternal_imprinting1.06662603
87MP0010234_abnormal_vibrissa_follicle1.06507561
88MP0003632_abnormal_nervous_system1.05299822
89MP0001324_abnormal_eye_pigmentation1.05045978
90MP0002332_abnormal_exercise_endurance1.04147711
91MP0001963_abnormal_hearing_physiology1.02449079
92MP0005391_vision/eye_phenotype1.02201342
93MP0008875_abnormal_xenobiotic_pharmacok1.02199871
94MP0002653_abnormal_ependyma_morphology1.01712105
95MP0002152_abnormal_brain_morphology1.01079141
96MP0008995_early_reproductive_senescence1.00328984
97MP0002160_abnormal_reproductive_system1.00224575
98MP0001986_abnormal_taste_sensitivity1.00035238
99MP0001485_abnormal_pinna_reflex0.99493005
100MP0005645_abnormal_hypothalamus_physiol0.99011103
101MP0006035_abnormal_mitochondrial_morpho0.98024034
102MP0005535_abnormal_body_temperature0.98022934
103MP0003646_muscle_fatigue0.97848430
104MP0004742_abnormal_vestibular_system0.97213020
105MP0005195_abnormal_posterior_eye0.97043183
106MP0004142_abnormal_muscle_tone0.96397804
107MP0002095_abnormal_skin_pigmentation0.95870887
108MP0000653_abnormal_sex_gland0.94907000
109MP0002210_abnormal_sex_determination0.94215998
110MP0000538_abnormal_urinary_bladder0.92887435
111MP0005389_reproductive_system_phenotype0.92577327
112MP0001929_abnormal_gametogenesis0.92076011
113MP0005174_abnormal_tail_pigmentation0.91853189
114MP0002837_dystrophic_cardiac_calcinosis0.91606554
115MP0002233_abnormal_nose_morphology0.91252098
116MP0006036_abnormal_mitochondrial_physio0.90500092
117MP0002069_abnormal_eating/drinking_beha0.89350253
118MP0000678_abnormal_parathyroid_gland0.87423704
119MP0003698_abnormal_male_reproductive0.86475980
120MP0001145_abnormal_male_reproductive0.81200488
121MP0002282_abnormal_trachea_morphology0.80024910
122MP0006292_abnormal_olfactory_placode0.79012702
123MP0005499_abnormal_olfactory_system0.77777664
124MP0005394_taste/olfaction_phenotype0.77777664
125MP0008872_abnormal_physiological_respon0.77437109
126MP0004484_altered_response_of0.77324011
127MP0004085_abnormal_heartbeat0.76652580
128MP0008874_decreased_physiological_sensi0.76317079
129MP0002752_abnormal_somatic_nervous0.75610408
130MP0001529_abnormal_vocalization0.73747772
131MP0002638_abnormal_pupillary_reflex0.70909323
132MP0003122_maternal_imprinting0.70174900
133MP0005551_abnormal_eye_electrophysiolog0.68097613
134MP0000751_myopathy0.65840809
135MP0001664_abnormal_digestion0.64300647
136MP0004215_abnormal_myocardial_fiber0.63814491
137MP0005377_hearing/vestibular/ear_phenot0.63270038
138MP0003878_abnormal_ear_physiology0.63270038
139MP0001177_atelectasis0.62346302
140MP0004145_abnormal_muscle_electrophysio0.62134583
141MP0005187_abnormal_penis_morphology0.61709502
142MP0003172_abnormal_lysosome_physiology0.60622735
143MP0003861_abnormal_nervous_system0.57577177
144MP0003634_abnormal_glial_cell0.57271793
145MP0003137_abnormal_impulse_conducting0.56750382
146MP0003119_abnormal_digestive_system0.56363862
147MP0004510_myositis0.54954553
148MP0002751_abnormal_autonomic_nervous0.53964688
149MP0000026_abnormal_inner_ear0.53890695
150MP0002082_postnatal_lethality0.53814189
151MP0010770_preweaning_lethality0.53814189
152MP0008961_abnormal_basal_metabolism0.52907064

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.67269788
2Visual hallucinations (HP:0002367)5.09652006
3Epileptic encephalopathy (HP:0200134)5.04509257
4Focal seizures (HP:0007359)5.00263125
5Febrile seizures (HP:0002373)4.80354275
6Hyperventilation (HP:0002883)4.77772913
7Myokymia (HP:0002411)4.76087291
8Atonic seizures (HP:0010819)4.70469074
9J-shaped sella turcica (HP:0002680)3.93300528
10Absence seizures (HP:0002121)3.88070290
11Dialeptic seizures (HP:0011146)3.80875876
12Abnormality of liposaccharide metabolism (HP:0010968)3.78596014
13Abnormality of glycosphingolipid metabolism (HP:0004343)3.78596014
14Abnormality of glycolipid metabolism (HP:0010969)3.78596014
15Pancreatic cysts (HP:0001737)3.73910670
16Pancreatic fibrosis (HP:0100732)3.64819479
17Generalized tonic-clonic seizures (HP:0002069)3.61332209
18Amblyopia (HP:0000646)3.52997537
19True hermaphroditism (HP:0010459)3.50176856
20Progressive cerebellar ataxia (HP:0002073)3.43146883
21Diastasis recti (HP:0001540)3.26251064
22Vertebral arch anomaly (HP:0008438)3.21073242
23Molar tooth sign on MRI (HP:0002419)3.19372749
24Abnormality of midbrain morphology (HP:0002418)3.19372749
25Broad alveolar ridges (HP:0000187)3.19299089
26Cerebral inclusion bodies (HP:0100314)3.09775224
27Abnormality of the labia minora (HP:0012880)3.09145905
28Nephronophthisis (HP:0000090)3.05217355
29Abnormality of the lower motor neuron (HP:0002366)2.95056099
30Action tremor (HP:0002345)2.94932096
31Medial flaring of the eyebrow (HP:0010747)2.94446143
32Carpal bone hypoplasia (HP:0001498)2.89814879
33Congenital stationary night blindness (HP:0007642)2.86935852
34Broad-based gait (HP:0002136)2.73931044
35Drooling (HP:0002307)2.73911194
36Excessive salivation (HP:0003781)2.73911194
37Neurofibrillary tangles (HP:0002185)2.72217045
38Pheochromocytoma (HP:0002666)2.72083175
39Supranuclear gaze palsy (HP:0000605)2.70251708
40Aplasia/Hypoplasia of the tibia (HP:0005772)2.68894460
41Chronic hepatic failure (HP:0100626)2.65914756
42Dysdiadochokinesis (HP:0002075)2.62434436
43Status epilepticus (HP:0002133)2.62136441
44Colon cancer (HP:0003003)2.61973829
45Limb dystonia (HP:0002451)2.60172774
46Poor eye contact (HP:0000817)2.58830012
47Acute necrotizing encephalopathy (HP:0006965)2.56770996
48Short tibia (HP:0005736)2.56757262
49Abnormality of the renal medulla (HP:0100957)2.55990868
50Postural instability (HP:0002172)2.54674438
51Epileptiform EEG discharges (HP:0011182)2.52863552
52Congenital primary aphakia (HP:0007707)2.51923891
53Impaired vibration sensation in the lower limbs (HP:0002166)2.50198893
54Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.49585997
55Impaired social interactions (HP:0000735)2.49212247
56Abnormal social behavior (HP:0012433)2.49212247
57Gaze-evoked nystagmus (HP:0000640)2.47524729
58Bradykinesia (HP:0002067)2.46353644
59Methylmalonic acidemia (HP:0002912)2.45477261
60Mitochondrial inheritance (HP:0001427)2.44079035
61Progressive macrocephaly (HP:0004481)2.41623621
62Methylmalonic aciduria (HP:0012120)2.41269665
63Absent speech (HP:0001344)2.40426608
64Increased CSF lactate (HP:0002490)2.39808521
65Intestinal atresia (HP:0011100)2.39791049
66Urinary bladder sphincter dysfunction (HP:0002839)2.36706082
67Abnormality of the renal cortex (HP:0011035)2.36672827
68Genital tract atresia (HP:0001827)2.35727530
69Aplasia/Hypoplasia of the tongue (HP:0010295)2.35567540
70Acute encephalopathy (HP:0006846)2.34689908
71Lipid accumulation in hepatocytes (HP:0006561)2.32200365
72Increased hepatocellular lipid droplets (HP:0006565)2.32074716
73EEG with generalized epileptiform discharges (HP:0011198)2.31939106
74Ankle clonus (HP:0011448)2.31852980
75Truncal ataxia (HP:0002078)2.28962054
76Nephrogenic diabetes insipidus (HP:0009806)2.28075480
77Impaired smooth pursuit (HP:0007772)2.26265682
78Hyperglycinemia (HP:0002154)2.25551752
79Neuroendocrine neoplasm (HP:0100634)2.24133289
80Vaginal atresia (HP:0000148)2.23564504
81Sclerocornea (HP:0000647)2.21987378
82Hypsarrhythmia (HP:0002521)2.21656279
83Dysmetria (HP:0001310)2.20938275
843-Methylglutaconic aciduria (HP:0003535)2.18886643
85Palpebral edema (HP:0100540)2.17831784
86Aplasia/Hypoplasia of the uvula (HP:0010293)2.16178074
87Thoracolumbar scoliosis (HP:0002944)2.16145302
88Cystic liver disease (HP:0006706)2.14918658
89Hemiparesis (HP:0001269)2.14177553
90Hepatocellular necrosis (HP:0001404)2.13928313
91Abnormal biliary tract physiology (HP:0012439)2.12037472
92Bile duct proliferation (HP:0001408)2.12037472
93Meckel diverticulum (HP:0002245)2.11871108
94Abnormality of the ileum (HP:0001549)2.11078187
95Abnormal mitochondria in muscle tissue (HP:0008316)2.11073738
96Flat acetabular roof (HP:0003180)2.09489312
97Abnormality of binocular vision (HP:0011514)2.09400092
98Diplopia (HP:0000651)2.09400092
99Anencephaly (HP:0002323)2.09101180
100Depression (HP:0000716)2.08818166
101Polydipsia (HP:0001959)2.08034380
102Abnormal drinking behavior (HP:0030082)2.08034380
103Dysostosis multiplex (HP:0000943)2.06950395
104Hypothermia (HP:0002045)2.06821063
105Genetic anticipation (HP:0003743)2.06642888
106Specific learning disability (HP:0001328)2.06612517
107Postaxial foot polydactyly (HP:0001830)2.06007609
108Progressive inability to walk (HP:0002505)2.05479077
109Type II lissencephaly (HP:0007260)2.04725674
110Severe global developmental delay (HP:0011344)2.04216864
111Fetal akinesia sequence (HP:0001989)2.03512684
112Flared iliac wings (HP:0002869)2.03391417
113Volvulus (HP:0002580)2.02941820
114Hepatic necrosis (HP:0002605)2.00571776
115Pendular nystagmus (HP:0012043)1.99702884
116Protruding tongue (HP:0010808)1.99044837
117Postaxial hand polydactyly (HP:0001162)1.98008880
118Anxiety (HP:0000739)1.97461848
119Urinary glycosaminoglycan excretion (HP:0003541)1.95771571
120Mucopolysacchariduria (HP:0008155)1.95771571
121Optic nerve hypoplasia (HP:0000609)1.94136896
122Abnormality of mucopolysaccharide metabolism (HP:0011020)1.93842427
123Abnormality of polysaccharide metabolism (HP:0011012)1.93842427
124Abnormality of glycosaminoglycan metabolism (HP:0004371)1.93842427
125Generalized myoclonic seizures (HP:0002123)1.93394282
126Male pseudohermaphroditism (HP:0000037)1.92901348
127Annular pancreas (HP:0001734)1.92842352
128Impaired vibratory sensation (HP:0002495)1.92133275
129Gastroesophageal reflux (HP:0002020)1.91636961
130Abnormal eating behavior (HP:0100738)1.90736932
131Deformed sella turcica (HP:0002681)1.89638508
132Papillary thyroid carcinoma (HP:0002895)1.89628486
133Inability to walk (HP:0002540)1.89347397
134Abnormal rod and cone electroretinograms (HP:0008323)1.88613898
135Abolished electroretinogram (ERG) (HP:0000550)1.88089886
136Thyroid carcinoma (HP:0002890)1.87967600
137Abnormality of chromosome stability (HP:0003220)1.87496218
138Mutism (HP:0002300)1.87110519
139Tubular atrophy (HP:0000092)1.87044913
140Abnormality of ocular smooth pursuit (HP:0000617)1.86524125
141Gait ataxia (HP:0002066)1.85973888
142Dysmetric saccades (HP:0000641)1.85464819
143Thyroiditis (HP:0100646)1.83350095
144Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82299377
145Congenital hepatic fibrosis (HP:0002612)1.81431701
146Abnormality of salivation (HP:0100755)1.81008405
147Insidious onset (HP:0003587)1.80602778
148Termporal pattern (HP:0011008)1.80602778
149Failure to thrive in infancy (HP:0001531)1.80401792
150Preaxial hand polydactyly (HP:0001177)1.79711565
151Global brain atrophy (HP:0002283)1.79563253
152Hyperinsulinemic hypoglycemia (HP:0000825)1.78578823
153Hypoplasia of the odontoid process (HP:0003311)1.78531631
154Gait imbalance (HP:0002141)1.75838966
155Attenuation of retinal blood vessels (HP:0007843)1.75576558
156Aplasia/Hypoplasia of the spleen (HP:0010451)1.75222171
157Clumsiness (HP:0002312)1.75210254
158Delusions (HP:0000746)1.74103599
159Hypoglycemic seizures (HP:0002173)1.74078447
160Abnormality of the corticospinal tract (HP:0002492)1.73613619
161Inappropriate behavior (HP:0000719)1.72426605
162Supernumerary spleens (HP:0009799)1.72187828
163Lower limb muscle weakness (HP:0007340)1.72067293
164Abnormality of secondary sexual hair (HP:0009888)1.70747373
165Abnormality of the axillary hair (HP:0100134)1.70747373
166Dysautonomia (HP:0002459)1.70529142
167Occipital encephalocele (HP:0002085)1.69702915
168Decreased central vision (HP:0007663)1.69622088
169Gastrointestinal atresia (HP:0002589)1.68702772
170Increased serum lactate (HP:0002151)1.68402921
171Lissencephaly (HP:0001339)1.67937790
172Aplasia/Hypoplasia of the hallux (HP:0008362)1.67836223
173Sloping forehead (HP:0000340)1.67536665
174Polyuria (HP:0000103)1.66578692
175Lactic acidosis (HP:0003128)1.66359623
176Renal Fanconi syndrome (HP:0001994)1.66191508
177Chromsome breakage (HP:0040012)1.66073100
178Septo-optic dysplasia (HP:0100842)1.65423368
179Asplenia (HP:0001746)1.64086807
180Triphalangeal thumb (HP:0001199)1.62663098
181Hypoplasia of the fovea (HP:0007750)1.62528193
182Aplasia/Hypoplasia of the fovea (HP:0008060)1.62528193
183Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.62173432
184Abnormality of alanine metabolism (HP:0010916)1.62173432
185Hyperalaninemia (HP:0003348)1.62173432
186Hypoplasia of the pons (HP:0012110)1.61627724
187Astigmatism (HP:0000483)1.61303207
188Chromosomal breakage induced by crosslinking agents (HP:0003221)1.61113901
189Decreased activity of mitochondrial respiratory chain (HP:0008972)1.60621822
190Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.60621822

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.43389496
2FRK3.91511639
3EPHA43.86985100
4WNK33.71101574
5CASK3.56296286
6MAP3K93.11212117
7MAP4K23.05356135
8PNCK2.89750245
9MAP2K72.88021592
10MAP3K42.74377555
11MAP3K122.58159554
12MINK12.47180009
13NTRK12.46949612
14RIPK42.44869137
15TRIM282.13127303
16PLK22.11162149
17GRK52.04609390
18ZAK2.04359762
19DAPK22.02869117
20DAPK12.01257093
21TNIK1.99704650
22NUAK11.98252117
23LATS21.98116450
24KSR21.94326618
25MAP2K41.92345459
26GRK11.79897848
27WNK41.79425194
28STK391.78851340
29ADRBK21.78581626
30AKT31.76581665
31MKNK21.68540726
32MUSK1.59418573
33NME11.51687073
34EIF2AK31.50608858
35SIK21.49185810
36MARK11.44798029
37PAK61.42484990
38DYRK21.42070405
39PLK41.41105237
40NTRK21.39827518
41KSR11.39429012
42ARAF1.39223130
43CAMKK11.37744792
44PRKCG1.37402510
45OXSR11.37147678
46SGK21.36306118
47BCR1.35669652
48PTK2B1.33948223
49FGR1.30651998
50WEE11.29757085
51ERBB31.29184824
52PRKD31.27774790
53MST41.24431928
54CSNK1G11.23992633
55BMPR21.20761729
56SIK31.19851302
57ACVR1B1.18130712
58SRPK11.17720239
59CSNK1G31.16794904
60CDK51.15674363
61STK381.14963959
62BRSK21.14759944
63FGFR21.14721057
64VRK11.12715605
65DYRK31.11489674
66BUB11.10962230
67CCNB11.06540811
68PAK31.06456608
69MKNK11.04905959
70VRK21.00524772
71RET1.00477203
72SGK4940.99593857
73SGK2230.99593857
74EIF2AK10.98851464
75CAMK2A0.96116862
76MAPK130.95867953
77BCKDK0.95786677
78NEK10.94370700
79TLK10.91842405
80CSNK1A1L0.91180097
81CDK190.89862708
82CAMK1G0.88537259
83PLK10.83528782
84STK160.80645867
85STK240.79812015
86MAP3K20.77669493
87PRPF4B0.76970974
88PINK10.76566887
89CAMK2D0.76318872
90CDC70.74669381
91RAF10.74051190
92SGK10.72042395
93PDK30.70082661
94PDK40.70082661
95SGK30.69678567
96STK38L0.68521214
97DYRK1A0.68387143
98PRKCE0.68158143
99TTK0.66126921
100TXK0.63139498
101PHKG10.62505036
102PHKG20.62505036
103BMPR1B0.62110807
104STK30.62051854
105CAMK2B0.61736767
106MAP2K10.61037790
107FER0.59974909
108TSSK60.58523770
109TIE10.57452431
110PDK20.57349162
111GRK70.56997312
112MAP3K130.56757302
113CSNK1G20.56634812
114BRAF0.56233319
115TYRO30.55956504
116PRKCZ0.55707190
117ADRBK10.55270143
118ATR0.55012797
119TGFBR10.53251240
120CAMKK20.53111126
121MAPK100.53002737
122CDK140.52973117
123GRK60.52898690
124PDPK10.52705012
125CDK30.52256971
126PRKCH0.52048072
127CSNK1A10.51983678
128MAP3K10.51306027
129CDK180.49316769
130YES10.49087290
131TAF10.47845109
132FES0.46870651
133RPS6KB10.46862483
134BRSK10.45843481
135PDK10.45440337
136ERBB40.44876059
137PKN10.44306957
138NLK0.44170038
139CDK150.43412589
140ATM0.43361219
141PRKCI0.43346575
142TAOK20.43109389
143BMX0.40927381
144ALK0.40250574
145MATK0.40222952
146EIF2AK20.40185962
147CSNK1D0.39654799
148MAPKAPK30.38802503
149CSNK1E0.38180751
150TAOK30.38066935
151MAP3K50.37421582
152CAMK10.37330677
153INSRR0.37131714
154CSNK2A10.35756260
155FLT30.35514222
156CDK11A0.35505774
157RPS6KA30.35324441
158RPS6KA50.34999866
159MAPK120.34778419
160CDK80.34633826
161OBSCN0.33760846
162EPHB20.32871608
163PLK30.31954364
164PRKACA0.31872414
165ROCK20.31652814
166CAMK2G0.30747433

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.99543408
2Synaptic vesicle cycle_Homo sapiens_hsa047213.98592481
3Protein export_Homo sapiens_hsa030603.06240682
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.03304103
5Long-term potentiation_Homo sapiens_hsa047202.90395576
6Collecting duct acid secretion_Homo sapiens_hsa049662.78677736
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.65807008
8GABAergic synapse_Homo sapiens_hsa047272.63096396
9Amphetamine addiction_Homo sapiens_hsa050312.50823198
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.47352821
11Taste transduction_Homo sapiens_hsa047422.46893838
12Circadian entrainment_Homo sapiens_hsa047132.42306301
13Glutamatergic synapse_Homo sapiens_hsa047242.37411254
14Propanoate metabolism_Homo sapiens_hsa006402.34399962
15Homologous recombination_Homo sapiens_hsa034402.33587397
16Fanconi anemia pathway_Homo sapiens_hsa034602.32629114
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.32563164
18Dopaminergic synapse_Homo sapiens_hsa047282.18193541
19Proteasome_Homo sapiens_hsa030502.18116874
20Olfactory transduction_Homo sapiens_hsa047402.11971547
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.10873216
22RNA polymerase_Homo sapiens_hsa030202.10728318
23Morphine addiction_Homo sapiens_hsa050322.07492583
24Steroid biosynthesis_Homo sapiens_hsa001001.99360760
25Insulin secretion_Homo sapiens_hsa049111.94865815
26Serotonergic synapse_Homo sapiens_hsa047261.93468528
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.92869182
28Salivary secretion_Homo sapiens_hsa049701.92321237
29Basal transcription factors_Homo sapiens_hsa030221.90673896
30Long-term depression_Homo sapiens_hsa047301.85517096
31Mismatch repair_Homo sapiens_hsa034301.82498212
32Non-homologous end-joining_Homo sapiens_hsa034501.76555198
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71145336
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69675608
35Selenocompound metabolism_Homo sapiens_hsa004501.68469637
36RNA degradation_Homo sapiens_hsa030181.66640328
37Cholinergic synapse_Homo sapiens_hsa047251.65336595
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.64841748
39Fatty acid elongation_Homo sapiens_hsa000621.57948381
40Calcium signaling pathway_Homo sapiens_hsa040201.55981146
41Gastric acid secretion_Homo sapiens_hsa049711.50589847
42Cocaine addiction_Homo sapiens_hsa050301.43095251
43Renin secretion_Homo sapiens_hsa049241.40185479
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39839983
45Oxytocin signaling pathway_Homo sapiens_hsa049211.37778299
46GnRH signaling pathway_Homo sapiens_hsa049121.37760067
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35056332
48Vibrio cholerae infection_Homo sapiens_hsa051101.31308347
49Linoleic acid metabolism_Homo sapiens_hsa005911.30844034
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.30573766
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.26869883
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25666852
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.23218330
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.21879173
55One carbon pool by folate_Homo sapiens_hsa006701.21704624
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21126232
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16242691
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15336107
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14130514
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13178133
61Caffeine metabolism_Homo sapiens_hsa002321.12210015
62Primary bile acid biosynthesis_Homo sapiens_hsa001201.11923216
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.10903029
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10203440
65Oxidative phosphorylation_Homo sapiens_hsa001901.09323191
66Tryptophan metabolism_Homo sapiens_hsa003801.09069751
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07896303
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07602865
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06878572
70Ether lipid metabolism_Homo sapiens_hsa005651.04131492
71Gap junction_Homo sapiens_hsa045401.04001100
72Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01436749
73Peroxisome_Homo sapiens_hsa041461.00452748
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99237557
75Fatty acid metabolism_Homo sapiens_hsa012120.98869902
76Melanogenesis_Homo sapiens_hsa049160.96816106
77Pyrimidine metabolism_Homo sapiens_hsa002400.96793135
78cAMP signaling pathway_Homo sapiens_hsa040240.96290996
79Oocyte meiosis_Homo sapiens_hsa041140.96162384
80Cardiac muscle contraction_Homo sapiens_hsa042600.95169205
81Dorso-ventral axis formation_Homo sapiens_hsa043200.94214325
82Nucleotide excision repair_Homo sapiens_hsa034200.93779489
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93772752
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.93211658
85Purine metabolism_Homo sapiens_hsa002300.92115435
86ErbB signaling pathway_Homo sapiens_hsa040120.90869711
87Estrogen signaling pathway_Homo sapiens_hsa049150.89072760
88Circadian rhythm_Homo sapiens_hsa047100.88106417
89Type II diabetes mellitus_Homo sapiens_hsa049300.87146996
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84289944
91RNA transport_Homo sapiens_hsa030130.84272045
92DNA replication_Homo sapiens_hsa030300.83184754
93Base excision repair_Homo sapiens_hsa034100.82302485
94Butanoate metabolism_Homo sapiens_hsa006500.81221218
95Alzheimers disease_Homo sapiens_hsa050100.80138690
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80019797
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79571626
98Glucagon signaling pathway_Homo sapiens_hsa049220.79529090
99Vitamin B6 metabolism_Homo sapiens_hsa007500.78754143
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77857071
101Glioma_Homo sapiens_hsa052140.77626270
102Metabolic pathways_Homo sapiens_hsa011000.77168572
103Chemical carcinogenesis_Homo sapiens_hsa052040.76773163
104Choline metabolism in cancer_Homo sapiens_hsa052310.74397166
105Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74203608
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.73925260
107Pancreatic secretion_Homo sapiens_hsa049720.73000944
108Ribosome_Homo sapiens_hsa030100.71401831
109Hedgehog signaling pathway_Homo sapiens_hsa043400.69895605
110Axon guidance_Homo sapiens_hsa043600.68166399
111Glutathione metabolism_Homo sapiens_hsa004800.67687816
112beta-Alanine metabolism_Homo sapiens_hsa004100.67685881
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67418306
114Retinol metabolism_Homo sapiens_hsa008300.67327891
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.64321106
116Pyruvate metabolism_Homo sapiens_hsa006200.61483120
117MAPK signaling pathway_Homo sapiens_hsa040100.61006767
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.59816191
119Fatty acid degradation_Homo sapiens_hsa000710.59329954
120Fatty acid biosynthesis_Homo sapiens_hsa000610.59267510
121Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59032863
122Parkinsons disease_Homo sapiens_hsa050120.59016501
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58184860
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57392740
125Basal cell carcinoma_Homo sapiens_hsa052170.55097743
126African trypanosomiasis_Homo sapiens_hsa051430.54923617
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54775249
128Spliceosome_Homo sapiens_hsa030400.53812150
129Type I diabetes mellitus_Homo sapiens_hsa049400.50916850
130Fructose and mannose metabolism_Homo sapiens_hsa000510.50915352
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50878669
132Folate biosynthesis_Homo sapiens_hsa007900.50752628
133Arachidonic acid metabolism_Homo sapiens_hsa005900.47838342
134Rheumatoid arthritis_Homo sapiens_hsa053230.47310455
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.45694207
136mTOR signaling pathway_Homo sapiens_hsa041500.45626352
137Insulin signaling pathway_Homo sapiens_hsa049100.44668363
138Bile secretion_Homo sapiens_hsa049760.43864851
139TGF-beta signaling pathway_Homo sapiens_hsa043500.43858693
140Inositol phosphate metabolism_Homo sapiens_hsa005620.43548906
141Thyroid hormone synthesis_Homo sapiens_hsa049180.42880459
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42539193
143Nitrogen metabolism_Homo sapiens_hsa009100.42367050
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41519403
145Ras signaling pathway_Homo sapiens_hsa040140.39067935
146Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37950557
147Rap1 signaling pathway_Homo sapiens_hsa040150.36229363
148Cell cycle_Homo sapiens_hsa041100.35927254
149Arginine and proline metabolism_Homo sapiens_hsa003300.35836171
150Huntingtons disease_Homo sapiens_hsa050160.35583369
151p53 signaling pathway_Homo sapiens_hsa041150.35557875
152Glycerolipid metabolism_Homo sapiens_hsa005610.35500673
153Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34514548
154Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34123468
155Prion diseases_Homo sapiens_hsa050200.33697125
156Regulation of autophagy_Homo sapiens_hsa041400.33565691
157VEGF signaling pathway_Homo sapiens_hsa043700.33271269
158Arginine biosynthesis_Homo sapiens_hsa002200.32001582
159Wnt signaling pathway_Homo sapiens_hsa043100.30975896
160Melanoma_Homo sapiens_hsa052180.30492272
161Cysteine and methionine metabolism_Homo sapiens_hsa002700.30188453
162Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29866640
163Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29838476
164Phototransduction_Homo sapiens_hsa047440.29017645
165Endometrial cancer_Homo sapiens_hsa052130.28158731
166Glycerophospholipid metabolism_Homo sapiens_hsa005640.28103937
167Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26876898
168Central carbon metabolism in cancer_Homo sapiens_hsa052300.26557118

Most similar genes based on co-expression Upload to Enrichr

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