KCTD7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the potassium channel tetramerization domain-containing protein family. Family members are identified on a structural basis and contain an amino-terminal domain similar to the T1 domain present in the voltage-gated potassium channel. Mutations in this gene have been associated with progressive myoclonic epilepsy-3. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.14711032
2cell wall macromolecule catabolic process (GO:0016998)9.06691529
3cell wall macromolecule metabolic process (GO:0044036)9.06691529
4fusion of sperm to egg plasma membrane (GO:0007342)8.89332437
5piRNA metabolic process (GO:0034587)7.22043102
6multicellular organism reproduction (GO:0032504)7.07332467
7acrosome assembly (GO:0001675)7.05535596
8axonemal dynein complex assembly (GO:0070286)6.89192730
9acrosome reaction (GO:0007340)6.88379259
10plasma membrane fusion (GO:0045026)6.82164503
11motile cilium assembly (GO:0044458)6.39579328
12axon ensheathment in central nervous system (GO:0032291)5.94244820
13central nervous system myelination (GO:0022010)5.94244820
14reproduction (GO:0000003)5.72648698
15sperm-egg recognition (GO:0035036)5.56079476
16nucleobase catabolic process (GO:0046113)5.52537755
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.45718984
18epithelial cilium movement (GO:0003351)5.23103023
19cell-cell recognition (GO:0009988)4.89590138
20microtubule depolymerization (GO:0007019)4.76250979
21male meiosis (GO:0007140)4.72511419
22sperm motility (GO:0030317)4.70432103
23calcium ion-dependent exocytosis (GO:0017156)4.69724528
24DNA methylation involved in gamete generation (GO:0043046)4.50150380
25cilium movement (GO:0003341)4.45344816
26negative regulation of inclusion body assembly (GO:0090084)4.37014303
27cell migration in hindbrain (GO:0021535)4.35970548
28postsynaptic membrane organization (GO:0001941)4.22626341
29binding of sperm to zona pellucida (GO:0007339)4.16073401
30spermatid development (GO:0007286)4.14033817
31single fertilization (GO:0007338)4.11579353
32synaptic vesicle exocytosis (GO:0016079)4.09324697
33sperm capacitation (GO:0048240)4.05787601
34axonal fasciculation (GO:0007413)4.02799020
35spermatid nucleus differentiation (GO:0007289)4.01574167
36establishment of mitochondrion localization (GO:0051654)4.01097012
37microtubule polymerization or depolymerization (GO:0031109)3.92910354
38neuron recognition (GO:0008038)3.91648997
39layer formation in cerebral cortex (GO:0021819)3.87005445
40ionotropic glutamate receptor signaling pathway (GO:0035235)3.83510915
41neuron cell-cell adhesion (GO:0007158)3.76583266
42regulation of synapse structural plasticity (GO:0051823)3.76325967
43protein K11-linked deubiquitination (GO:0035871)3.75037700
44protein localization to cilium (GO:0061512)3.73364288
45fatty acid elongation (GO:0030497)3.72894353
46regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.57798619
47regulation of synaptic vesicle transport (GO:1902803)3.57051386
48long-chain fatty acid biosynthetic process (GO:0042759)3.56690900
49cilium morphogenesis (GO:0060271)3.52698630
50negative regulation of neurotransmitter transport (GO:0051589)3.48748338
51vocalization behavior (GO:0071625)3.47054463
52neurofilament cytoskeleton organization (GO:0060052)3.46964617
53negative regulation of neurotransmitter secretion (GO:0046929)3.45913095
54neurotransmitter-gated ion channel clustering (GO:0072578)3.42893076
55nonmotile primary cilium assembly (GO:0035058)3.37901878
56negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.33250934
57cell recognition (GO:0008037)3.27835186
58synaptonemal complex organization (GO:0070193)3.27626167
59fertilization (GO:0009566)3.27452888
60glutamate secretion (GO:0014047)3.24713148
61regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.23385830
62presynaptic membrane organization (GO:0097090)3.20823241
63gamma-aminobutyric acid transport (GO:0015812)3.18581904
64neuronal ion channel clustering (GO:0045161)3.18412099
65meiotic cell cycle (GO:0051321)3.17588376
66response to methylmercury (GO:0051597)3.16981308
67synaptic transmission, glutamatergic (GO:0035249)3.16731133
68macroautophagy (GO:0016236)3.13559233
69dendrite morphogenesis (GO:0048813)3.11256439
70axon extension (GO:0048675)3.10635252
71myelination (GO:0042552)3.08487824
72ensheathment of neurons (GO:0007272)3.08413292
73axon ensheathment (GO:0008366)3.08413292
74synapse assembly (GO:0007416)3.06264479
75activated T cell proliferation (GO:0050798)3.05716499
76establishment of nucleus localization (GO:0040023)3.05354889
77mitochondrion transport along microtubule (GO:0047497)3.03792801
78establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.03792801
79negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.03688893
80negative regulation of cell killing (GO:0031342)3.03688893
81ER overload response (GO:0006983)3.02960962
82locomotory exploration behavior (GO:0035641)3.02330228
83positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.01626868
84regulation of cilium movement (GO:0003352)3.01124412
85microtubule severing (GO:0051013)3.00939135
86synaptic vesicle docking involved in exocytosis (GO:0016081)3.00778244
87organelle transport along microtubule (GO:0072384)2.99897419
88regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.99878946
89regulation of response to osmotic stress (GO:0047484)2.97568061
90negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.96306483
91negative regulation of translation, ncRNA-mediated (GO:0040033)2.96306483
92regulation of translation, ncRNA-mediated (GO:0045974)2.96306483
93meiotic nuclear division (GO:0007126)2.95390706
94synaptonemal complex assembly (GO:0007130)2.93208621
95exploration behavior (GO:0035640)2.90778684
96glutamate receptor signaling pathway (GO:0007215)2.89867419
97regulation of ARF protein signal transduction (GO:0032012)2.89446475
98adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.89156726
99membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.88425356
100regulation of glutamate receptor signaling pathway (GO:1900449)2.87520738
101dendritic spine morphogenesis (GO:0060997)2.84212172
102protein polyglutamylation (GO:0018095)2.83961790
103neuronal action potential propagation (GO:0019227)2.83134816
104presynaptic membrane assembly (GO:0097105)2.82920800
105neurotransmitter secretion (GO:0007269)2.82103788
106regulation of inclusion body assembly (GO:0090083)2.81586438
107myelin maintenance (GO:0043217)2.81027935
108glycosphingolipid biosynthetic process (GO:0006688)2.80531514
109clathrin coat assembly (GO:0048268)2.78865780
110positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.78253319
111cerebellar Purkinje cell differentiation (GO:0021702)2.78066701
112ventricular system development (GO:0021591)2.77658564
113regulation of glycogen (starch) synthase activity (GO:2000465)2.77584802
114photoreceptor cell differentiation (GO:0046530)2.77365353
115eye photoreceptor cell differentiation (GO:0001754)2.77365353
116cerebellar granule cell differentiation (GO:0021707)2.75490421
117neuron projection extension (GO:1990138)2.75220961
118adult walking behavior (GO:0007628)2.75216825
119negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.75129779
120protein palmitoylation (GO:0018345)2.73602863
121positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.73402151
122mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.73402151
123regulation of synaptic vesicle exocytosis (GO:2000300)2.72744990
124polyol catabolic process (GO:0046174)2.72247460
125axoneme assembly (GO:0035082)2.71680646
126response to auditory stimulus (GO:0010996)2.71562674
127spermatogenesis (GO:0007283)2.68935936
128positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.68751238
129positive regulation of synapse assembly (GO:0051965)2.68689003
130male gamete generation (GO:0048232)2.67812042
131centriole replication (GO:0007099)2.67295231
132auditory behavior (GO:0031223)2.66190464
133pyrimidine nucleobase catabolic process (GO:0006208)2.66002799
134positive regulation of oligodendrocyte differentiation (GO:0048714)2.65396727
135synaptic vesicle maturation (GO:0016188)2.65135294
136neuron remodeling (GO:0016322)2.64316371
137cellular response to monoamine stimulus (GO:0071868)2.63919743
138cellular response to catecholamine stimulus (GO:0071870)2.63919743
139response to redox state (GO:0051775)2.63263135
140ganglioside metabolic process (GO:0001573)2.63212418
141central nervous system projection neuron axonogenesis (GO:0021952)2.62909265
142positive regulation of macroautophagy (GO:0016239)2.62592578
143regulation of short-term neuronal synaptic plasticity (GO:0048172)2.62460092
144nerve growth factor signaling pathway (GO:0038180)2.62427677
145negative regulation of execution phase of apoptosis (GO:1900118)2.62252640
146response to dietary excess (GO:0002021)2.62090031
147long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.61037830
148regulation of NFAT protein import into nucleus (GO:0051532)2.59098862
149microtubule-based movement (GO:0007018)2.58184648
150regulation of synaptic transmission, glutamatergic (GO:0051966)2.58090056
151negative regulation of axonogenesis (GO:0050771)2.55877099
152negative regulation of organelle assembly (GO:1902116)2.55371723
153glycerol metabolic process (GO:0006071)2.53559875
154transmission of nerve impulse (GO:0019226)2.53391349
155protein localization to synapse (GO:0035418)2.53040450
156neuron-neuron synaptic transmission (GO:0007270)2.52282117
157male meiosis I (GO:0007141)2.51661972
158positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.51165774
159cellular process involved in reproduction in multicellular organism (GO:0022412)2.51046317
160positive regulation of axon extension (GO:0045773)2.49690511
161regulation of autophagic vacuole assembly (GO:2000785)2.49547139
162oligodendrocyte differentiation (GO:0048709)2.49079922
163negative regulation of synaptic transmission, GABAergic (GO:0032229)2.49024659
164negative regulation of mast cell activation (GO:0033004)2.48524241
165cholesterol biosynthetic process (GO:0006695)2.48410278
166positive regulation of synapse maturation (GO:0090129)2.47674908
167gamete generation (GO:0007276)2.47316545
168regulation of neurotransmitter secretion (GO:0046928)2.47033842
169regulation of axon extension (GO:0030516)2.46199826
170glycerophospholipid catabolic process (GO:0046475)2.45333813
171long-term memory (GO:0007616)2.45276549
172regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.42899183
173regulation of axonogenesis (GO:0050770)2.42604772
174response to nerve growth factor (GO:1990089)2.42457308
175cellular response to nerve growth factor stimulus (GO:1990090)2.42457308
176regulation of extent of cell growth (GO:0061387)2.39871150
177neuromuscular process controlling balance (GO:0050885)2.38952270
178positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.38087719
179acidic amino acid transport (GO:0015800)2.36668949
180calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.35942837
181regulation of respiratory system process (GO:0044065)2.33097505
182cerebral cortex radially oriented cell migration (GO:0021799)2.32184876
183positive regulation of mitochondrial fission (GO:0090141)2.32070281
184negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.31068973

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.04061169
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.67760214
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.88830028
4EZH2_22144423_ChIP-Seq_EOC_Human3.66442089
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.93268734
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38504768
7GBX2_23144817_ChIP-Seq_PC3_Human2.35689256
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.20570669
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.15864702
10DROSHA_22980978_ChIP-Seq_HELA_Human2.15435684
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.10558936
12IKZF1_21737484_ChIP-ChIP_HCT116_Human2.04441547
13REST_21632747_ChIP-Seq_MESCs_Mouse2.02142782
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97919143
15CBX2_27304074_Chip-Seq_ESCs_Mouse1.93218471
16IGF1R_20145208_ChIP-Seq_DFB_Human1.80836180
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80326692
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78102364
19AR_21572438_ChIP-Seq_LNCaP_Human1.74468108
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.72243910
21TAF15_26573619_Chip-Seq_HEK293_Human1.71821071
22* KDM2B_26808549_Chip-Seq_K562_Human1.71139514
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.70732394
24ZFP281_18757296_ChIP-ChIP_E14_Mouse1.69212752
25SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.69203271
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.68912476
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.68912476
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.67841995
29ELK4_26923725_Chip-Seq_MESODERM_Mouse1.66753138
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.65408867
31DNAJC2_21179169_ChIP-ChIP_NT2_Human1.63484740
32EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.63206245
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.62415477
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60836581
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.59037371
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57741825
37KDM2B_26808549_Chip-Seq_DND41_Human1.53734884
38ZNF274_21170338_ChIP-Seq_K562_Hela1.53287878
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.53111944
40TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.50486900
41VDR_22108803_ChIP-Seq_LS180_Human1.49907600
42RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.48389037
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44965287
44CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.44885999
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.44269289
46TAL1_26923725_Chip-Seq_HPCs_Mouse1.44058365
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42960530
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42960530
49OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.42452392
50TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42345143
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.40913902
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40745357
53SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.40535959
54* KDM2B_26808549_Chip-Seq_REH_Human1.39961798
55SMAD4_21799915_ChIP-Seq_A2780_Human1.39751693
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38640968
57SUZ12_18555785_Chip-Seq_ESCs_Mouse1.38077427
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37895507
59* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.37679169
60CMYC_18555785_Chip-Seq_ESCs_Mouse1.37217755
61KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.37133254
62MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.36872839
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.36824008
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36523081
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.35785326
66EZH2_27294783_Chip-Seq_ESCs_Mouse1.35721987
67ER_23166858_ChIP-Seq_MCF-7_Human1.33743539
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32938361
69SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32159074
70TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.31844026
71P300_18555785_Chip-Seq_ESCs_Mouse1.30596329
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30317301
73RNF2_27304074_Chip-Seq_ESCs_Mouse1.30300830
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29107595
75STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28710008
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.27880786
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25962186
78STAT3_18555785_Chip-Seq_ESCs_Mouse1.25630169
79* KDM2B_26808549_Chip-Seq_JURKAT_Human1.24880189
80EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.24384383
81SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.24291658
82ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23938127
83CRX_20693478_ChIP-Seq_RETINA_Mouse1.23847197
84P53_22387025_ChIP-Seq_ESCs_Mouse1.23549027
85CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21700476
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20733162
87GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19484197
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19090931
89FLI1_27457419_Chip-Seq_LIVER_Mouse1.18667946
90RNF2_27304074_Chip-Seq_NSC_Mouse1.18070122
91STAT3_23295773_ChIP-Seq_U87_Human1.18008977
92TCF4_23295773_ChIP-Seq_U87_Human1.17600259
93RARB_27405468_Chip-Seq_BRAIN_Mouse1.17428300
94RUNX1_27457419_Chip-Seq_LIVER_Mouse1.17378002
95SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17103924
96BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16741923
97TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16236408
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.15900887
99* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15106022
100OCT4_18555785_Chip-Seq_ESCs_Mouse1.15031110
101SOX2_18555785_Chip-Seq_ESCs_Mouse1.14330485
102SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13644600
103OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13203976
104GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13118308
105RING1B_27294783_Chip-Seq_ESCs_Mouse1.12078685
106PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11865415
107SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11836470
108KAP1_22055183_ChIP-Seq_ESCs_Mouse1.11238951
109TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10657058
110KLF4_18555785_Chip-Seq_ESCs_Mouse1.10241312
111* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09936755
112ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09397018
113KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.08923363
114P300_19829295_ChIP-Seq_ESCs_Human1.08791883
115SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08506366
116EZH2_27294783_Chip-Seq_NPCs_Mouse1.08441436
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08187983
118JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08117933
119NFE2_27457419_Chip-Seq_LIVER_Mouse1.07959905
120WT1_19549856_ChIP-ChIP_CCG9911_Human1.07576335
121VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07379995
122RUNX2_22187159_ChIP-Seq_PCA_Human1.06697765
123SMAD1_18555785_Chip-Seq_ESCs_Mouse1.06519336
124P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05938258
125SMAD3_21741376_ChIP-Seq_EPCs_Human1.05559427
126GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.05502940
127GF1B_26923725_Chip-Seq_HPCs_Mouse1.04791885
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03950215
129PU1_27457419_Chip-Seq_LIVER_Mouse1.03741029
130WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03364107
131* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03277683
132UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02619861
133ESRRB_18555785_Chip-Seq_ESCs_Mouse1.02522339
134SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.02246960
135ERG_21242973_ChIP-ChIP_JURKAT_Human1.01843486
136* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.01769232
137AR_19668381_ChIP-Seq_PC3_Human1.01540111
138CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00661351
139CTCF_18555785_Chip-Seq_ESCs_Mouse1.00307709
140GATA1_19941827_ChIP-Seq_MEL_Mouse0.98408890
141HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97918515
142SPI1_23127762_ChIP-Seq_K562_Human0.95556751
143TET1_21490601_ChIP-Seq_MESCs_Mouse0.92401595
144PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.90203225
145NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90136416
146RUNX_20019798_ChIP-Seq_JUKART_Human0.89323977
147MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.87624873
148LXR_22292898_ChIP-Seq_THP-1_Human0.87389438
149NR3C1_23031785_ChIP-Seq_PC12_Mouse0.86426604
150OCT4_19829295_ChIP-Seq_ESCs_Human0.85923879
151GATA1_26923725_Chip-Seq_HPCs_Mouse0.84975796
152CTCF_27219007_Chip-Seq_Bcells_Human0.82779106
153* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.80546428
154* SOX2_21211035_ChIP-Seq_LN229_Gbm0.79572412
155YAP1_20516196_ChIP-Seq_MESCs_Mouse0.77929366
156KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.76346966
157TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.74119319
158DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.73856813
159TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.73280027
160LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72680559
161E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.72625621
162SMC4_20622854_ChIP-Seq_HELA_Human0.72336606

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.20923868
2MP0005409_darkened_coat_color3.57079806
3MP0009046_muscle_twitch3.44062496
4MP0004270_analgesia3.20373317
5MP0002653_abnormal_ependyma_morphology3.02962366
6MP0003122_maternal_imprinting2.83269314
7MP0003880_abnormal_central_pattern2.80063872
8MP0000920_abnormal_myelination2.77829133
9MP0003698_abnormal_male_reproductive2.66787794
10MP0005423_abnormal_somatic_nervous2.61230000
11MP0004859_abnormal_synaptic_plasticity2.38797681
12MP0003635_abnormal_synaptic_transmissio2.37187349
13MP0001929_abnormal_gametogenesis2.32674299
14MP0002064_seizures2.28937434
15MP0000569_abnormal_digit_pigmentation2.19003338
16MP0001529_abnormal_vocalization2.13772159
17MP0002734_abnormal_mechanical_nocicepti2.08475649
18MP0003329_amyloid_beta_deposits2.07617774
19MP0002272_abnormal_nervous_system2.06032210
20MP0004043_abnormal_pH_regulation2.04816873
21MP0003172_abnormal_lysosome_physiology1.99434751
22MP0003787_abnormal_imprinting1.90878673
23MP0000015_abnormal_ear_pigmentation1.87861627
24MP0001486_abnormal_startle_reflex1.85460671
25MP0001984_abnormal_olfaction1.85412335
26MP0009745_abnormal_behavioral_response1.84624556
27MP0000778_abnormal_nervous_system1.84233000
28MP0000955_abnormal_spinal_cord1.80429750
29MP0001905_abnormal_dopamine_level1.78948989
30MP0002063_abnormal_learning/memory/cond1.77543558
31MP0004142_abnormal_muscle_tone1.74900832
32MP0002572_abnormal_emotion/affect_behav1.73442329
33MP0001968_abnormal_touch/_nociception1.72781985
34MP0002733_abnormal_thermal_nociception1.67069196
35MP0008569_lethality_at_weaning1.61711338
36MP0002229_neurodegeneration1.58197861
37MP0005551_abnormal_eye_electrophysiolog1.56563840
38MP0003121_genomic_imprinting1.56214755
39MP0004811_abnormal_neuron_physiology1.56113302
40MP0002102_abnormal_ear_morphology1.55833941
41MP0002735_abnormal_chemical_nociception1.55816505
42MP0003634_abnormal_glial_cell1.55426740
43MP0003632_abnormal_nervous_system1.54662320
44MP0002184_abnormal_innervation1.52602689
45MP0002909_abnormal_adrenal_gland1.51699699
46MP0004742_abnormal_vestibular_system1.51347783
47MP0008877_abnormal_DNA_methylation1.49602530
48MP0003690_abnormal_glial_cell1.49053963
49MP0002067_abnormal_sensory_capabilities1.49043014
50MP0002210_abnormal_sex_determination1.45456856
51MP0001970_abnormal_pain_threshold1.44324551
52MP0002882_abnormal_neuron_morphology1.41610953
53MP0003136_yellow_coat_color1.41397729
54MP0003631_nervous_system_phenotype1.39737852
55MP0006276_abnormal_autonomic_nervous1.38961388
56MP0001145_abnormal_male_reproductive1.36528717
57MP0002161_abnormal_fertility/fecundity1.34512196
58MP0005386_behavior/neurological_phenoty1.33165052
59MP0004924_abnormal_behavior1.33165052
60MP0002557_abnormal_social/conspecific_i1.30558167
61MP0004858_abnormal_nervous_system1.29236483
62MP0008260_abnormal_autophagy1.28747355
63MP0000747_muscle_weakness1.26263103
64MP0005645_abnormal_hypothalamus_physiol1.25744082
65MP0002638_abnormal_pupillary_reflex1.24593542
66MP0000653_abnormal_sex_gland1.22937030
67MP0002066_abnormal_motor_capabilities/c1.22546551
68MP0005535_abnormal_body_temperature1.22500386
69MP0004885_abnormal_endolymph1.19737837
70MP0005058_abnormal_lysosome_morphology1.18610273
71MP0001299_abnormal_eye_distance/1.17290441
72MP0002752_abnormal_somatic_nervous1.15376626
73MP0002736_abnormal_nociception_after1.15039184
74MP0001661_extended_life_span1.14744287
75MP0003633_abnormal_nervous_system1.14131143
76MP0001440_abnormal_grooming_behavior1.12619581
77MP0003950_abnormal_plasma_membrane1.12598693
78MP0001502_abnormal_circadian_rhythm1.11505825
79MP0003221_abnormal_cardiomyocyte_apopto1.08445213
80MP0003303_peritoneal_inflammation1.08162034
81MP0003724_increased_susceptibility_to1.07853444
82MP0005174_abnormal_tail_pigmentation1.06828245
83MP0005623_abnormal_meninges_morphology1.03773392
84MP0000604_amyloidosis1.03279740
85MP0002152_abnormal_brain_morphology1.03241380
86MP0001986_abnormal_taste_sensitivity1.02679259
87MP0000631_abnormal_neuroendocrine_gland1.01615486
88MP0009780_abnormal_chondrocyte_physiolo1.00756790
89MP0005171_absent_coat_pigmentation0.99772739
90MP0005646_abnormal_pituitary_gland0.98348018
91MP0004130_abnormal_muscle_cell0.95483277
92MP0001963_abnormal_hearing_physiology0.95442996
93MP0003656_abnormal_erythrocyte_physiolo0.94052856
94MP0005379_endocrine/exocrine_gland_phen0.93953640
95MP0001188_hyperpigmentation0.90236593
96MP0003436_decreased_susceptibility_to0.88469107
97MP0005167_abnormal_blood-brain_barrier0.87764128
98MP0003195_calcinosis0.86574802
99MP0002822_catalepsy0.85254630
100MP0001485_abnormal_pinna_reflex0.84587334
101MP0001958_emphysema0.83746434
102MP0000026_abnormal_inner_ear0.80545581
103MP0003861_abnormal_nervous_system0.77480656
104MP0005253_abnormal_eye_physiology0.77369294
105MP0000372_irregular_coat_pigmentation0.77041927
106MP0004147_increased_porphyrin_level0.76983446
107MP0005195_abnormal_posterior_eye0.76193797
108MP0008874_decreased_physiological_sensi0.76190489
109MP0002069_abnormal_eating/drinking_beha0.75905390
110MP0000462_abnormal_digestive_system0.74458117
111MP0003890_abnormal_embryonic-extraembry0.72648017
112MP0002928_abnormal_bile_duct0.70307772
113MP0003879_abnormal_hair_cell0.67952381
114MP0008789_abnormal_olfactory_epithelium0.66686322
115MP0004381_abnormal_hair_follicle0.66681127
116MP0005394_taste/olfaction_phenotype0.65879018
117MP0005499_abnormal_olfactory_system0.65879018
118MP0003183_abnormal_peptide_metabolism0.65628755
119MP0000647_abnormal_sebaceous_gland0.65541538
120MP0003300_gastrointestinal_ulcer0.65443400
121MP0002751_abnormal_autonomic_nervous0.65209311
122MP0005671_abnormal_response_to0.64541297
123MP0005257_abnormal_intraocular_pressure0.64205358
124MP0001943_abnormal_respiration0.64078710
125MP0000343_altered_response_to0.62932604
126MP0002419_abnormal_innate_immunity0.61015153
127MP0001324_abnormal_eye_pigmentation0.56254912
128MP0001501_abnormal_sleep_pattern0.55502036
129MP0003948_abnormal_gas_homeostasis0.54682084
130MP0006082_CNS_inflammation0.54636960

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.91319770
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.22713974
3Absent/shortened dynein arms (HP:0200106)7.22713974
4Abnormal respiratory motile cilium physiology (HP:0012261)5.79869282
5Abnormal respiratory motile cilium morphology (HP:0005938)5.72492589
6Abnormal respiratory epithelium morphology (HP:0012253)5.72492589
7Sensory axonal neuropathy (HP:0003390)5.63374032
8Rhinitis (HP:0012384)5.05652219
9Overriding aorta (HP:0002623)4.83778073
10Abnormal ciliary motility (HP:0012262)4.64408160
11Insomnia (HP:0100785)4.60925317
12Toxemia of pregnancy (HP:0100603)4.55257253
13Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.28545467
14Degeneration of the lateral corticospinal tracts (HP:0002314)4.28545467
15Chronic bronchitis (HP:0004469)4.19104550
16Hyperacusis (HP:0010780)4.13614964
17Renovascular hypertension (HP:0100817)4.06179586
18Elfin facies (HP:0004428)3.99532505
19Flat cornea (HP:0007720)3.75364440
20Polyphagia (HP:0002591)3.71715278
21Gait imbalance (HP:0002141)3.65497929
22Cortical dysplasia (HP:0002539)3.53814339
23Neurofibrillary tangles (HP:0002185)3.52108061
24Abnormality of the corticospinal tract (HP:0002492)3.48355451
25Medial flaring of the eyebrow (HP:0010747)3.48334261
26Congenital primary aphakia (HP:0007707)3.33440125
27Amyotrophic lateral sclerosis (HP:0007354)3.26084709
28Retinal dysplasia (HP:0007973)3.25639510
29Excessive salivation (HP:0003781)3.25297382
30Drooling (HP:0002307)3.21150058
31Ankle clonus (HP:0011448)3.15685115
32Nephrogenic diabetes insipidus (HP:0009806)3.12548868
33Morphological abnormality of the pyramidal tract (HP:0002062)3.12211111
34Renal duplication (HP:0000075)3.07928497
35Chronic otitis media (HP:0000389)2.99745026
36Polygenic inheritance (HP:0010982)2.96163488
37Abnormal eating behavior (HP:0100738)2.93510414
38Supranuclear gaze palsy (HP:0000605)2.93309205
39Slow saccadic eye movements (HP:0000514)2.84393231
40Abnormality of the diencephalon (HP:0010662)2.83869023
41Focal motor seizures (HP:0011153)2.81431369
42Abnormality of the lower motor neuron (HP:0002366)2.79719980
43Mutism (HP:0002300)2.79020659
44Failure to thrive in infancy (HP:0001531)2.77996368
45Vaginal atresia (HP:0000148)2.74327009
46Genital tract atresia (HP:0001827)2.74172401
47Hyporeflexia of lower limbs (HP:0002600)2.68759976
48Chronic sinusitis (HP:0011109)2.68477838
49Cerebral inclusion bodies (HP:0100314)2.68034606
50Hypoplasia of the brainstem (HP:0002365)2.66922390
51Aplasia/Hypoplasia of the brainstem (HP:0007362)2.66922390
52Pheochromocytoma (HP:0002666)2.65761182
53Nasal polyposis (HP:0100582)2.65243298
54Diplopia (HP:0000651)2.63906177
55Abnormality of binocular vision (HP:0011514)2.63906177
56Neuronal loss in central nervous system (HP:0002529)2.59212631
57Hemiplegia (HP:0002301)2.56265689
58Spastic gait (HP:0002064)2.56085819
59Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.54211637
60Poor coordination (HP:0002370)2.52317094
61Papilledema (HP:0001085)2.49910224
62Infertility (HP:0000789)2.48606669
63Hepatoblastoma (HP:0002884)2.45867835
64Agitation (HP:0000713)2.43216620
65Abnormal hair whorl (HP:0010721)2.41887826
66Ulnar claw (HP:0001178)2.40420388
67Parakeratosis (HP:0001036)2.39734241
68Termporal pattern (HP:0011008)2.36479095
69Insidious onset (HP:0003587)2.36479095
70Bronchiectasis (HP:0002110)2.33795462
71Curly hair (HP:0002212)2.33298202
72Neuroendocrine neoplasm (HP:0100634)2.32746560
73Atonic seizures (HP:0010819)2.31706516
74Apathy (HP:0000741)2.30785565
75Abnormality of glycolipid metabolism (HP:0010969)2.28917074
76Abnormality of liposaccharide metabolism (HP:0010968)2.28917074
77Abnormality of glycosphingolipid metabolism (HP:0004343)2.28917074
78Urinary urgency (HP:0000012)2.27104402
79Nephronophthisis (HP:0000090)2.26257648
80Decreased motor nerve conduction velocity (HP:0003431)2.22860731
81* Hypoplasia of the corpus callosum (HP:0002079)2.21522976
82Spastic paraplegia (HP:0001258)2.19783360
83Hammertoe (HP:0001765)2.19152407
84Spastic tetraplegia (HP:0002510)2.18213893
85Retinal atrophy (HP:0001105)2.16961708
86Absent speech (HP:0001344)2.16809294
87Hand muscle atrophy (HP:0009130)2.16724716
88Diminished motivation (HP:0000745)2.14056652
89Type II lissencephaly (HP:0007260)2.13618608
90Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.12935402
91Increased nuchal translucency (HP:0010880)2.11587859
92Inappropriate behavior (HP:0000719)2.11045762
93Paraplegia (HP:0010550)2.09972365
94Abnormality of midbrain morphology (HP:0002418)2.07327468
95Molar tooth sign on MRI (HP:0002419)2.07327468
96Clonus (HP:0002169)2.07080309
97Abnormality of the motor neurons (HP:0002450)2.06816010
98Abnormal neuron morphology (HP:0012757)2.06816010
99Abnormality of saccadic eye movements (HP:0000570)2.06756142
100Aplasia/Hypoplasia of the lens (HP:0008063)2.06329651
101Megalencephaly (HP:0001355)2.05916097
102Pointed chin (HP:0000307)2.05806592
103Myokymia (HP:0002411)2.05675721
104Pachygyria (HP:0001302)2.04459986
105Sleep apnea (HP:0010535)2.04054898
106Bladder diverticulum (HP:0000015)2.01594580
107Epileptiform EEG discharges (HP:0011182)2.00187264
108Peripheral hypomyelination (HP:0007182)1.99441481
109Cerebral hemorrhage (HP:0001342)1.99068742
110Bowel diverticulosis (HP:0005222)1.98036396
111Urinary bladder sphincter dysfunction (HP:0002839)1.97509256
112Rapidly progressive (HP:0003678)1.97243008
113Cerebral hypomyelination (HP:0006808)1.97205232
114Hypsarrhythmia (HP:0002521)1.94639526
115Atrophy/Degeneration involving motor neurons (HP:0007373)1.94525605
116Lower limb muscle weakness (HP:0007340)1.94332259
117Steppage gait (HP:0003376)1.94135984
118Hyperventilation (HP:0002883)1.94015820
119Clumsiness (HP:0002312)1.93886306
120* Truncal ataxia (HP:0002078)1.93034877
121Disinhibition (HP:0000734)1.93018039
122Abnormality of the nasal mucosa (HP:0000433)1.92894730
123Tongue fasciculations (HP:0001308)1.91994332
124EEG with generalized epileptiform discharges (HP:0011198)1.91519393
125Progressive cerebellar ataxia (HP:0002073)1.91309784
126Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.90932546
127Eczematoid dermatitis (HP:0000976)1.90368389
128Specific learning disability (HP:0001328)1.90241488
129Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.89750249
130Anosmia (HP:0000458)1.89101241
131Hypoventilation (HP:0002791)1.87336139
132Generalized tonic-clonic seizures (HP:0002069)1.86726573
133Impaired vibration sensation in the lower limbs (HP:0002166)1.86556112
134Megalocornea (HP:0000485)1.86156790
135Abnormality of salivation (HP:0100755)1.84655843
136Genetic anticipation (HP:0003743)1.84390568
137Onion bulb formation (HP:0003383)1.84335911
138Dysmetria (HP:0001310)1.83729958
139Broad-based gait (HP:0002136)1.83623776
140Hypothermia (HP:0002045)1.83279269
141Abnormality of the labia minora (HP:0012880)1.81649182
142Intention tremor (HP:0002080)1.81393628
143Hypercalcemia (HP:0003072)1.80101245
144Bronchitis (HP:0012387)1.80026797
145Hemiparesis (HP:0001269)1.78135067
146Postural instability (HP:0002172)1.77285784
147Heterotopia (HP:0002282)1.76033122
148Gaze-evoked nystagmus (HP:0000640)1.75465536
149Neoplasm of the heart (HP:0100544)1.75170633
150Impaired smooth pursuit (HP:0007772)1.74789808
151Action tremor (HP:0002345)1.74499624
152* Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.71985119
153Limb ataxia (HP:0002070)1.71446772
154Distal sensory impairment (HP:0002936)1.70862427
155Limb dystonia (HP:0002451)1.68842047
156Muscle fibrillation (HP:0010546)1.68746962
157Epileptic encephalopathy (HP:0200134)1.67291555
158Febrile seizures (HP:0002373)1.67077269
159Focal seizures (HP:0007359)1.66053087
160Lissencephaly (HP:0001339)1.62393744
161Delusions (HP:0000746)1.61749707
162Gait ataxia (HP:0002066)1.61084005

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK34.61350567
2PDK44.61350567
3STK393.98686373
4SIK23.20995036
5MAP3K92.85986624
6PDK22.76006080
7PRPF4B2.65055503
8MARK12.57331765
9YES12.57322448
10PKN12.49132432
11CASK2.34703364
12OXSR12.28967445
13WNK42.07732801
14EPHA32.07277201
15CAMKK22.03484248
16TYRO32.00123050
17NTRK11.89094908
18BMPR1B1.79037130
19CAMKK11.68247606
20UHMK11.65081772
21PNCK1.62677532
22NTRK21.62089236
23MAPKAPK51.61125347
24MAP2K71.59176744
25KSR11.56748592
26SGK4941.47941738
27SGK2231.47941738
28DYRK21.42869926
29MINK11.42187298
30TESK21.40350689
31BLK1.37407387
32RIPK41.36645588
33MAPK131.33241266
34MAP3K61.29745852
35EPHB11.27115983
36GRK11.24171260
37CDK191.23766845
38TESK11.20098390
39PAK61.18426757
40AKT31.17530340
41PDGFRB1.16335443
42KSR21.14650410
43PHKG21.11988358
44PHKG11.11988358
45MAPK151.11220131
46MARK21.05599853
47MAP3K41.00747572
48SCYL20.98216325
49TNIK0.95422650
50CAMK1D0.94047317
51NTRK30.93903642
52SIK30.93366209
53BCR0.91997976
54CSNK1G20.89910482
55CDK50.89766491
56MAP4K20.89578877
57FGR0.89479200
58PRKD30.89159028
59CAMK2B0.89075656
60LIMK10.87977148
61CSNK1G30.86581488
62NEK60.85453365
63RET0.83706234
64ICK0.82901857
65GRK50.82403929
66WNK10.82386279
67FGFR20.81855767
68MAP3K110.80952856
69MAP2K40.80592320
70GRK70.78989128
71CSNK1A1L0.76727045
72PRKCZ0.75861253
73IRAK10.75021066
74CAMK1G0.74576383
75ADRBK20.74032736
76MAPK120.73345416
77BCKDK0.73187936
78PAK30.72888760
79TRIB30.71850779
80EPHA40.70149923
81CDC42BPA0.68980883
82CAMK2D0.67642627
83JAK20.67287488
84CAMK2A0.66632724
85PRKCH0.65960830
86PRKG10.65787372
87ROCK20.65757524
88DDR20.65695501
89MAP4K10.64465140
90LMTK20.64224190
91CSK0.62446821
92PLK20.62115217
93CDK140.60088018
94TNK20.58506869
95PDGFRA0.57262024
96SYK0.57062215
97PINK10.56530685
98PRKCE0.56273477
99CSNK1G10.55392644
100HCK0.55354452
101CAMK40.55284486
102PDK10.55001849
103DAPK30.54439828
104CAMK2G0.49154697
105CAMK10.48848743
106CDK180.48174157
107PRKCG0.48151714
108CDK150.48008617
109MAPK100.47539215
110MAP3K100.47193674
111DYRK1B0.46700525
112HIPK20.46654573
113JAK10.45769008
114SGK20.45182185
115PRKCQ0.44805045
116BRD40.44618597
117FYN0.43844382
118RIPK10.43374959
119CLK10.43347303
120TYK20.42910597
121GSK3A0.42801537
122DAPK20.41837799
123MAPK70.41752533
124PTK2B0.41661299
125VRK10.41572986
126IRAK20.40984149
127MAP3K20.40685155
128SGK30.39982450
129STK110.38055401
130ZAP700.37984732
131PDPK10.37951506
132DYRK1A0.37739911
133FES0.37527483
134STK380.37486230
135SGK10.37125744
136EGFR0.35604196
137MUSK0.35173186
138CDK11A0.35098358
139RPS6KA20.35036230
140TRPM70.34594154
141BRAF0.34516927
142MET0.33613877

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.11202753
2Steroid biosynthesis_Homo sapiens_hsa001003.04878161
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.90918349
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.55608306
5Fatty acid elongation_Homo sapiens_hsa000622.47668754
6Ether lipid metabolism_Homo sapiens_hsa005652.32742380
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.20605678
8Synaptic vesicle cycle_Homo sapiens_hsa047212.04525319
9SNARE interactions in vesicular transport_Homo sapiens_hsa041302.02942165
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87012343
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.84049668
12Linoleic acid metabolism_Homo sapiens_hsa005911.80008344
13Pentose phosphate pathway_Homo sapiens_hsa000301.79930993
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.75948884
15Glutamatergic synapse_Homo sapiens_hsa047241.65088735
16GABAergic synapse_Homo sapiens_hsa047271.64639979
17Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.64353740
18Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.62959741
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.56277547
20Dopaminergic synapse_Homo sapiens_hsa047281.53113522
21Taste transduction_Homo sapiens_hsa047421.52309194
22Morphine addiction_Homo sapiens_hsa050321.50950834
23Circadian entrainment_Homo sapiens_hsa047131.50106186
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.47147657
25Phototransduction_Homo sapiens_hsa047441.47132509
26Serotonergic synapse_Homo sapiens_hsa047261.46620845
27Dorso-ventral axis formation_Homo sapiens_hsa043201.46408594
28Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.45896465
29Olfactory transduction_Homo sapiens_hsa047401.44330449
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39936456
31Neurotrophin signaling pathway_Homo sapiens_hsa047221.39179635
32Gastric acid secretion_Homo sapiens_hsa049711.35958157
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.32554281
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.32313096
35Amphetamine addiction_Homo sapiens_hsa050311.32123033
36Insulin secretion_Homo sapiens_hsa049111.31833999
37Sulfur metabolism_Homo sapiens_hsa009201.28686890
38Osteoclast differentiation_Homo sapiens_hsa043801.25211049
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22777913
40Axon guidance_Homo sapiens_hsa043601.20019586
41Nicotine addiction_Homo sapiens_hsa050331.19683351
42Cocaine addiction_Homo sapiens_hsa050301.19347227
43Protein export_Homo sapiens_hsa030601.18017345
44Chemokine signaling pathway_Homo sapiens_hsa040621.13508174
45Sphingolipid metabolism_Homo sapiens_hsa006001.12006230
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11924964
47Alcoholism_Homo sapiens_hsa050341.11050653
48Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.10921649
49Long-term depression_Homo sapiens_hsa047301.10462119
50GnRH signaling pathway_Homo sapiens_hsa049121.10191617
51VEGF signaling pathway_Homo sapiens_hsa043701.07814662
52Long-term potentiation_Homo sapiens_hsa047201.07416804
53ErbB signaling pathway_Homo sapiens_hsa040121.07175648
54Fatty acid biosynthesis_Homo sapiens_hsa000611.05711161
55B cell receptor signaling pathway_Homo sapiens_hsa046621.04992360
56Colorectal cancer_Homo sapiens_hsa052101.04945252
57Lysosome_Homo sapiens_hsa041421.03764528
58Collecting duct acid secretion_Homo sapiens_hsa049661.02735695
59Renin secretion_Homo sapiens_hsa049241.01724263
60Pyruvate metabolism_Homo sapiens_hsa006201.00815426
61Endometrial cancer_Homo sapiens_hsa052130.98821844
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98288459
63Rap1 signaling pathway_Homo sapiens_hsa040150.98220542
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98204613
65Choline metabolism in cancer_Homo sapiens_hsa052310.97302038
66Notch signaling pathway_Homo sapiens_hsa043300.97293477
67Huntingtons disease_Homo sapiens_hsa050160.96957380
68Salmonella infection_Homo sapiens_hsa051320.95633765
69Oxidative phosphorylation_Homo sapiens_hsa001900.95468841
70Prolactin signaling pathway_Homo sapiens_hsa049170.94388837
71N-Glycan biosynthesis_Homo sapiens_hsa005100.93136847
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92904351
73Alzheimers disease_Homo sapiens_hsa050100.92109758
74Cholinergic synapse_Homo sapiens_hsa047250.91785352
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90147520
76Vibrio cholerae infection_Homo sapiens_hsa051100.87731254
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87650714
78Tuberculosis_Homo sapiens_hsa051520.86911282
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.86723502
80T cell receptor signaling pathway_Homo sapiens_hsa046600.86433300
81MAPK signaling pathway_Homo sapiens_hsa040100.85774000
82Non-small cell lung cancer_Homo sapiens_hsa052230.83945172
83Propanoate metabolism_Homo sapiens_hsa006400.81318592
84Butanoate metabolism_Homo sapiens_hsa006500.80455007
85Salivary secretion_Homo sapiens_hsa049700.80251074
86Inositol phosphate metabolism_Homo sapiens_hsa005620.80210790
87Glioma_Homo sapiens_hsa052140.79786443
88mTOR signaling pathway_Homo sapiens_hsa041500.79361593
89Renal cell carcinoma_Homo sapiens_hsa052110.79130683
90Cardiac muscle contraction_Homo sapiens_hsa042600.78796483
91Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78591561
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.78044768
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77351548
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76635012
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76121419
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75346244
97Other glycan degradation_Homo sapiens_hsa005110.74966937
98Endocytosis_Homo sapiens_hsa041440.74376789
99Fatty acid metabolism_Homo sapiens_hsa012120.72748330
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.72370776
101Glycerolipid metabolism_Homo sapiens_hsa005610.70706867
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.68910513
103Oocyte meiosis_Homo sapiens_hsa041140.68491140
104Parkinsons disease_Homo sapiens_hsa050120.68047897
105Acute myeloid leukemia_Homo sapiens_hsa052210.66260110
106ABC transporters_Homo sapiens_hsa020100.65435692
107Insulin signaling pathway_Homo sapiens_hsa049100.65346988
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.63836750
109Pancreatic cancer_Homo sapiens_hsa052120.63307636
110Shigellosis_Homo sapiens_hsa051310.63274571
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63109902
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62617098
113Melanogenesis_Homo sapiens_hsa049160.61045962
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60679287
115Systemic lupus erythematosus_Homo sapiens_hsa053220.60415874
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.59337072
117AMPK signaling pathway_Homo sapiens_hsa041520.59242170
118Estrogen signaling pathway_Homo sapiens_hsa049150.56863052
119Chronic myeloid leukemia_Homo sapiens_hsa052200.56661520
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55006921
121HIF-1 signaling pathway_Homo sapiens_hsa040660.54547436
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54276260
123Basal transcription factors_Homo sapiens_hsa030220.54250448
124Renin-angiotensin system_Homo sapiens_hsa046140.53787499
125Leishmaniasis_Homo sapiens_hsa051400.53767346
126Ras signaling pathway_Homo sapiens_hsa040140.53626150
127Prion diseases_Homo sapiens_hsa050200.51735794
128FoxO signaling pathway_Homo sapiens_hsa040680.51441116
129Gap junction_Homo sapiens_hsa045400.50994706
130Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50656785
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50308091
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50036048
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49554987
134Calcium signaling pathway_Homo sapiens_hsa040200.49177946
135Regulation of autophagy_Homo sapiens_hsa041400.48044196
136Platelet activation_Homo sapiens_hsa046110.47468300
137Oxytocin signaling pathway_Homo sapiens_hsa049210.47183621
138cAMP signaling pathway_Homo sapiens_hsa040240.45683787
139Phagosome_Homo sapiens_hsa041450.45292009
140Histidine metabolism_Homo sapiens_hsa003400.43269655
141Ovarian steroidogenesis_Homo sapiens_hsa049130.43187304
142Type II diabetes mellitus_Homo sapiens_hsa049300.41869005
143Glucagon signaling pathway_Homo sapiens_hsa049220.41383972
144Pancreatic secretion_Homo sapiens_hsa049720.38968573
145Thyroid hormone synthesis_Homo sapiens_hsa049180.37766783
146Cysteine and methionine metabolism_Homo sapiens_hsa002700.36433545
147Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35737556

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