KCTD9P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of RIG-I signaling pathway (GO:0039535)5.76242882
2regulation of necroptotic process (GO:0060544)5.71642465
3regulation of female gonad development (GO:2000194)5.66504620
4regulation of protein polyubiquitination (GO:1902914)5.55734480
5NIK/NF-kappaB signaling (GO:0038061)5.39073088
6necroptotic process (GO:0070266)4.92614934
7regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.83117802
8regulation of hypersensitivity (GO:0002883)4.75504291
9interkinetic nuclear migration (GO:0022027)4.66667227
10negative regulation of necroptotic process (GO:0060546)4.62092697
11programmed necrotic cell death (GO:0097300)4.40633235
12necrotic cell death (GO:0070265)4.30736024
13negative regulation of peptidyl-serine phosphorylation (GO:0033137)4.26012585
14positive regulation of granulocyte differentiation (GO:0030854)4.16963840
15centriole replication (GO:0007099)4.09608673
16phagocytosis, engulfment (GO:0006911)4.09024627
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.01046982
18regulation of necrotic cell death (GO:0010939)3.96079607
19fat-soluble vitamin biosynthetic process (GO:0042362)3.89398378
20negative regulation of interleukin-17 production (GO:0032700)3.88336283
21purine deoxyribonucleotide metabolic process (GO:0009151)3.83603616
22neutrophil activation involved in immune response (GO:0002283)3.83564209
23purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.83231749
24negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.77459808
25negative regulation of necrotic cell death (GO:0060547)3.74550219
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.70004629
27chemokine-mediated signaling pathway (GO:0070098)3.68361658
28positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.67336122
29positive regulation of mast cell degranulation (GO:0043306)3.61250881
30positive regulation of mast cell activation involved in immune response (GO:0033008)3.61250881
31regulation of B cell receptor signaling pathway (GO:0050855)3.60951664
32proteasome assembly (GO:0043248)3.56799071
33positive regulation of mast cell activation (GO:0033005)3.56178701
34regulation of interleukin-17 production (GO:0032660)3.52268995
35negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.47910935
36negative regulation of T-helper cell differentiation (GO:0045623)3.47910935
37purine deoxyribonucleotide catabolic process (GO:0009155)3.47679765
38protein localization to Golgi apparatus (GO:0034067)3.45263325
39positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.43018979
40regulation of mast cell activation (GO:0033003)3.35086662
41negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.33442169
42regulation of T-helper 1 cell differentiation (GO:0045625)3.27649046
43mast cell activation (GO:0045576)3.24861140
44mature B cell differentiation involved in immune response (GO:0002313)3.21109303
45negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.20672301
46positive regulation of immunoglobulin mediated immune response (GO:0002891)3.18988948
47positive regulation of B cell mediated immunity (GO:0002714)3.18988948
48positive regulation of alpha-beta T cell proliferation (GO:0046641)3.18939780
49immunoglobulin mediated immune response (GO:0016064)3.18869160
50ribosomal small subunit assembly (GO:0000028)3.18602479
51I-kappaB phosphorylation (GO:0007252)3.18282949
52positive regulation of isotype switching (GO:0045830)3.17820602
53regulation of mast cell activation involved in immune response (GO:0033006)3.16264585
54detection of other organism (GO:0098543)3.14762277
55microglial cell activation (GO:0001774)3.13389724
56regulation of mast cell degranulation (GO:0043304)3.13091738
57protein localization to peroxisome (GO:0072662)3.12812866
58protein targeting to peroxisome (GO:0006625)3.12812866
59establishment of protein localization to peroxisome (GO:0072663)3.12812866
60detection of bacterium (GO:0016045)3.10355577
61regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.09326976
62peroxisome fission (GO:0016559)3.08504475
63response to pheromone (GO:0019236)3.06284555
64positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.03834111
65deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.02089418
66purinergic nucleotide receptor signaling pathway (GO:0035590)3.00878646
67adenosine metabolic process (GO:0046085)3.00045569
68detection of molecule of bacterial origin (GO:0032490)2.99469660
69purine nucleotide salvage (GO:0032261)2.98775118
70response to xenobiotic stimulus (GO:0009410)2.98566897
71membrane invagination (GO:0010324)2.98555224
72purine-containing compound salvage (GO:0043101)2.96227185
73detection of external biotic stimulus (GO:0098581)2.94930628
74regulation of T-helper 2 cell differentiation (GO:0045628)2.94401714
75poly(A)+ mRNA export from nucleus (GO:0016973)2.92244190
76positive regulation of interleukin-17 production (GO:0032740)2.84001180
77B cell mediated immunity (GO:0019724)2.83673221
78hepatocyte apoptotic process (GO:0097284)2.82731261
79positive regulation of DNA recombination (GO:0045911)2.82330490
80regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.81589595
81mast cell activation involved in immune response (GO:0002279)2.78234511
82mast cell degranulation (GO:0043303)2.78234511
83parental behavior (GO:0060746)2.77509763
84peroxisomal transport (GO:0043574)2.77437500
85regulation of myeloid leukocyte mediated immunity (GO:0002886)2.76646712
86tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.75216352
87RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.75216352
88positive regulation of T cell cytokine production (GO:0002726)2.74435382
89mucosal-associated lymphoid tissue development (GO:0048537)2.73520235
90Peyers patch development (GO:0048541)2.73520235
91SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)2.71261187
92negative regulation of mast cell activation (GO:0033004)2.70298156
93positive regulation of interleukin-1 beta production (GO:0032731)2.69888747
94negative regulation of neurotransmitter secretion (GO:0046929)2.68970053
95hepatocyte differentiation (GO:0070365)2.66216924
96mature B cell differentiation (GO:0002335)2.63744202
97monoamine transport (GO:0015844)2.62604850
98intracellular protein transmembrane import (GO:0044743)2.62162204
99regulation of immunoglobulin mediated immune response (GO:0002889)2.61487997
100regulation of B cell mediated immunity (GO:0002712)2.60102651

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ELF1_17652178_ChIP-ChIP_JURKAT_Human5.38001143
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.37016243
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.74529183
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.59533651
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.26193157
6IGF1R_20145208_ChIP-Seq_DFB_Human3.12818655
7SCL_19346495_ChIP-Seq_HPC-7_Human3.06787962
8RUNX_20019798_ChIP-Seq_JUKART_Human2.57989793
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.52937369
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.49830972
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.48756254
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.30271053
13GATA3_27048872_Chip-Seq_THYMUS_Human2.24056559
14SPI1_23547873_ChIP-Seq_NB4_Human2.18673850
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.03384361
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.98525165
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.97993019
18PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97414733
19MYB_26560356_Chip-Seq_TH2_Human1.93236675
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.88643920
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80328367
22VDR_24787735_ChIP-Seq_THP-1_Human1.74924469
23GBX2_23144817_ChIP-Seq_PC3_Human1.74512180
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.72294991
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.71065744
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70441445
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68685802
28CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.63745786
29FOXA1_21572438_ChIP-Seq_LNCaP_Human1.62415582
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.60249560
31SALL4_22934838_ChIP-ChIP_CD34+_Human1.59135428
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.57439831
33SPI1_23127762_ChIP-Seq_K562_Human1.56826040
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55765628
35VDR_24763502_ChIP-Seq_THP-1_Human1.55534556
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.54368082
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52563906
38FUS_26573619_Chip-Seq_HEK293_Human1.51540793
39EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.47836863
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.44053702
41RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.42437878
42VDR_23849224_ChIP-Seq_CD4+_Human1.40754538
43TAF15_26573619_Chip-Seq_HEK293_Human1.36870529
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35833292
45GATA3_26560356_Chip-Seq_TH2_Human1.34199069
46FOXP3_21729870_ChIP-Seq_TREG_Human1.33772049
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.33106231
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.32663800
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29788642
50GATA3_26560356_Chip-Seq_TH1_Human1.29401296
51GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.28645735
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24685520
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22369478
54AR_25329375_ChIP-Seq_VCAP_Human1.21979553
55PRDM14_20953172_ChIP-Seq_ESCs_Human1.21296411
56TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.21013741
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20376132
58MYB_26560356_Chip-Seq_TH1_Human1.19804589
59PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17641334
60GATA1_22025678_ChIP-Seq_K562_Human1.17525813
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17324927
62ELK1_19687146_ChIP-ChIP_HELA_Human1.16913522
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.16834659
64MYB_21317192_ChIP-Seq_ERMYB_Mouse1.16642022
65VDR_22108803_ChIP-Seq_LS180_Human1.14661162
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14567901
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13339392
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12410935
69EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10762480
70STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08730652
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08697843
72GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07430630
73PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07282366
74BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06051629
75E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05244734
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03572715
77RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02327591
78SMRT_27268052_Chip-Seq_Bcells_Human1.01443542
79TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.99977603
80TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99833194
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98321807
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98186273
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96318431
84HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94297968
85GATA1_19941826_ChIP-Seq_K562_Human0.93445280
86ERG_20517297_ChIP-Seq_VCAP_Human0.92156970
87CIITA_25753668_ChIP-Seq_RAJI_Human0.91096456
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90564481
89FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90266444
90NMYC_18555785_Chip-Seq_ESCs_Mouse0.90133640
91RUNX1_27457419_Chip-Seq_LIVER_Mouse0.89154582
92EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.89068447
93STAT3_18555785_Chip-Seq_ESCs_Mouse0.88946776
94AR_20517297_ChIP-Seq_VCAP_Human0.88786993
95GATA1_19941827_ChIP-Seq_MEL86_Mouse0.88785092
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88622694
97KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88527033
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88210212
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87812751
100CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87648307

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.53990861
2MP0001835_abnormal_antigen_presentation3.85469066
3MP0006292_abnormal_olfactory_placode3.62221619
4MP0003806_abnormal_nucleotide_metabolis3.28401148
5MP0003724_increased_susceptibility_to3.09938649
6MP0004147_increased_porphyrin_level2.60233190
7MP0003787_abnormal_imprinting2.28899642
8MP0009785_altered_susceptibility_to2.28284361
9MP0010155_abnormal_intestine_physiology2.24710468
10MP0005075_abnormal_melanosome_morpholog2.21938189
11MP0001188_hyperpigmentation2.21901590
12MP0001545_abnormal_hematopoietic_system2.19717292
13MP0005397_hematopoietic_system_phenotyp2.19717292
14MP0008260_abnormal_autophagy2.09805018
15MP0003646_muscle_fatigue2.00912313
16MP0002396_abnormal_hematopoietic_system2.00430322
17MP0009697_abnormal_copulation1.98651228
18MP0008877_abnormal_DNA_methylation1.92204383
19MP0005671_abnormal_response_to1.92180187
20MP0003866_abnormal_defecation1.91913115
21MP0002148_abnormal_hypersensitivity_rea1.87493959
22MP0001800_abnormal_humoral_immune1.83637078
23MP0001764_abnormal_homeostasis1.75695436
24MP0002419_abnormal_innate_immunity1.74206471
25MP0005025_abnormal_response_to1.70482769
26MP0002723_abnormal_immune_serum1.66392149
27MP0009764_decreased_sensitivity_to1.62937088
28MP0002420_abnormal_adaptive_immunity1.62607701
29MP0002452_abnormal_antigen_presenting1.59912655
30MP0002398_abnormal_bone_marrow1.59438359
31MP0003183_abnormal_peptide_metabolism1.59051378
32MP0001819_abnormal_immune_cell1.58648762
33MP0005410_abnormal_fertilization1.57299406
34MP0008057_abnormal_DNA_replication1.52856242
35MP0005000_abnormal_immune_tolerance1.44496737
36MP0001790_abnormal_immune_system1.44225597
37MP0005387_immune_system_phenotype1.44225597
38MP0005464_abnormal_platelet_physiology1.43106229
39MP0000716_abnormal_immune_system1.42030165
40MP0005084_abnormal_gallbladder_morpholo1.41719845
41MP0002166_altered_tumor_susceptibility1.39852920
42MP0002722_abnormal_immune_system1.39761850
43MP0004883_abnormal_blood_vessel1.38305647
44MP0003436_decreased_susceptibility_to1.37055426
45MP0000703_abnormal_thymus_morphology1.36579194
46MP0005174_abnormal_tail_pigmentation1.35248309
47MP0000689_abnormal_spleen_morphology1.34884736
48MP0006036_abnormal_mitochondrial_physio1.34854896
49MP0003656_abnormal_erythrocyte_physiolo1.31857476
50MP0004142_abnormal_muscle_tone1.30239158
51MP0004130_abnormal_muscle_cell1.29901719
52MP0003448_altered_tumor_morphology1.29246241
53MP0002132_abnormal_respiratory_system1.26243666
54MP0000685_abnormal_immune_system1.25536050
55MP0000858_altered_metastatic_potential1.24109211
56MP0003763_abnormal_thymus_physiology1.23525157
57MP0005376_homeostasis/metabolism_phenot1.21773348
58MP0005266_abnormal_metabolism1.20900154
59MP0003878_abnormal_ear_physiology1.20796598
60MP0005377_hearing/vestibular/ear_phenot1.20796598
61MP0001845_abnormal_inflammatory_respons1.20617070
62MP0002429_abnormal_blood_cell1.18961676
63MP0002837_dystrophic_cardiac_calcinosis1.17703182
64MP0000465_gastrointestinal_hemorrhage1.14323028
65MP0009333_abnormal_splenocyte_physiolog1.13298266
66MP0000681_abnormal_thyroid_gland1.09563587
67MP0001986_abnormal_taste_sensitivity1.08230247
68MP0003172_abnormal_lysosome_physiology1.07804756
69MP0002006_tumorigenesis1.06122121
70MP0001191_abnormal_skin_condition1.05010531
71MP0005360_urolithiasis1.04606471
72MP0004084_abnormal_cardiac_muscle1.01878667
73MP0006082_CNS_inflammation0.99099829
74MP0001177_atelectasis0.98391291
75MP0005164_abnormal_response_to0.96079150
76MP0004381_abnormal_hair_follicle0.94396943
77MP0002876_abnormal_thyroid_physiology0.93786914
78MP0002332_abnormal_exercise_endurance0.93448541
79MP0004145_abnormal_muscle_electrophysio0.92076643
80MP0005166_decreased_susceptibility_to0.91949944
81MP0001664_abnormal_digestion0.91001082
82MP0008469_abnormal_protein_level0.90919304
83MP0004043_abnormal_pH_regulation0.89166822
84MP0000249_abnormal_blood_vessel0.88787798
85MP0005535_abnormal_body_temperature0.86252248
86MP0004808_abnormal_hematopoietic_stem0.84645542
87MP0002405_respiratory_system_inflammati0.84205847
88MP0000516_abnormal_urinary_system0.82103038
89MP0005367_renal/urinary_system_phenotyp0.82103038
90MP0009278_abnormal_bone_marrow0.81640446
91MP0002019_abnormal_tumor_incidence0.80970739
92MP0005645_abnormal_hypothalamus_physiol0.80468667
93MP0002127_abnormal_cardiovascular_syste0.76077326
94MP0003300_gastrointestinal_ulcer0.75188474
95MP0009763_increased_sensitivity_to0.73756690
96MP0001853_heart_inflammation0.69860066
97MP0004036_abnormal_muscle_relaxation0.68808736
98MP0001756_abnormal_urination0.66197781
99MP0005448_abnormal_energy_balance0.64484193
100MP0002234_abnormal_pharynx_morphology0.63720184

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the phalanges of the 2nd finger (HP:0009541)4.15078487
2Metaphyseal dysplasia (HP:0100255)4.14335776
3Enlarged epiphyses (HP:0010580)4.01648033
4Thrombocytosis (HP:0001894)3.94496625
5Papilledema (HP:0001085)3.89876243
6Limb hypertonia (HP:0002509)3.57964191
7Brushfield spots (HP:0001088)3.39127978
8Neonatal respiratory distress (HP:0002643)3.38733897
9Partial agenesis of the corpus callosum (HP:0001338)3.34094663
10Global brain atrophy (HP:0002283)3.33602257
11Progressive microcephaly (HP:0000253)3.30851436
12Short tibia (HP:0005736)3.27258226
13Autoimmune hemolytic anemia (HP:0001890)3.19081720
14Aplasia/Hypoplasia of the tibia (HP:0005772)3.12230728
15Acute hepatic failure (HP:0006554)3.06441989
16Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.05548012
17Abnormal delayed hypersensitivity skin test (HP:0002963)2.95735834
18Abnormality of B cell number (HP:0010975)2.92761505
19Syringomyelia (HP:0003396)2.92209808
20Spinal cord lesions (HP:0100561)2.92209808
21Severe global developmental delay (HP:0011344)2.87501074
22Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.75780469
23Recurrent cutaneous fungal infections (HP:0011370)2.74394925
24Chronic mucocutaneous candidiasis (HP:0002728)2.74394925
25Thin bony cortex (HP:0002753)2.73007652
26Gingival bleeding (HP:0000225)2.72986673
27Abnormality of the costochondral junction (HP:0000919)2.71922856
28Fibular aplasia (HP:0002990)2.68732982
29Elevated erythrocyte sedimentation rate (HP:0003565)2.63442653
30Abnormality of lateral ventricle (HP:0030047)2.63236322
31Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.61929091
32Abnormality of T cell number (HP:0011839)2.61448214
33T lymphocytopenia (HP:0005403)2.51040914
34Alveolar cell carcinoma (HP:0006519)2.49275521
35Autoimmune thrombocytopenia (HP:0001973)2.49004391
36Neoplasm of the tracheobronchial system (HP:0100552)2.45965665
37Female pseudohermaphroditism (HP:0010458)2.41382891
38B lymphocytopenia (HP:0010976)2.40625953
39Abnormality of the phalanges of the 5th finger (HP:0004213)2.39529691
40Conjunctival telangiectasia (HP:0000524)2.37371861
41Degeneration of anterior horn cells (HP:0002398)2.35232942
42Abnormality of the anterior horn cell (HP:0006802)2.35232942
43Deep philtrum (HP:0002002)2.31508844
44Papillary thyroid carcinoma (HP:0002895)2.31164470
45Recurrent fungal infections (HP:0002841)2.29420857
46Abnormality of the 2nd finger (HP:0004100)2.28902086
47Glossoptosis (HP:0000162)2.27889701
48Spontaneous abortion (HP:0005268)2.26826833
49Abnormality of the heme biosynthetic pathway (HP:0010472)2.26009816
50Obstructive lung disease (HP:0006536)2.25016270
51Chronic obstructive pulmonary disease (HP:0006510)2.25016270
52Peritonitis (HP:0002586)2.24263698
53Abnormality of the prostate (HP:0008775)2.23175691
54Abnormal epiphyseal ossification (HP:0010656)2.22722507
55Recurrent viral infections (HP:0004429)2.18467376
56Short middle phalanx of the 5th finger (HP:0004220)2.17856420
57Abnormality of the vasculature of the conjunctiva (HP:0008054)2.17424451
58Reticulocytopenia (HP:0001896)2.16617143
59Epistaxis (HP:0000421)2.15849919
60Ankyloglossia (HP:0010296)2.15055226
61Metaphyseal irregularity (HP:0003025)2.11982591
62Optic neuritis (HP:0100653)2.11243056
63Retrobulbar optic neuritis (HP:0100654)2.11243056
64Tinnitus (HP:0000360)2.09626852
65Reduced antithrombin III activity (HP:0001976)2.08375540
66Delayed epiphyseal ossification (HP:0002663)2.08266479
67Urticaria (HP:0001025)2.06001565
68Hyperglycinemia (HP:0002154)2.05219055
69Porencephaly (HP:0002132)2.02928048
70Abnormality of dental color (HP:0011073)1.99900332
71Death in infancy (HP:0001522)1.99870528
72Abnormality of the periventricular white matter (HP:0002518)1.98217877
73Epiphyseal stippling (HP:0010655)1.97699103
74Submucous cleft hard palate (HP:0000176)1.97160532
75Keratoconjunctivitis (HP:0001096)1.95820700
76Keratoconjunctivitis sicca (HP:0001097)1.91769559
77Abnormality of T cells (HP:0002843)1.90448333
78Acute myeloid leukemia (HP:0004808)1.90027579
79Acute lymphatic leukemia (HP:0006721)1.88633367
80Thyroid carcinoma (HP:0002890)1.88612112
81Vasculitis (HP:0002633)1.88533592
82Inflammation of the large intestine (HP:0002037)1.87917281
83Thickened calvaria (HP:0002684)1.86590019
84Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.86270331
85Beaking of vertebral bodies (HP:0004568)1.86021561
86Recurrent skin infections (HP:0001581)1.84743119
87Recurrent bacterial skin infections (HP:0005406)1.84677404
88Polyneuropathy (HP:0001271)1.83824832
89Leukocytosis (HP:0001974)1.82278776
90Thickened nuchal skin fold (HP:0000474)1.82266064
91Spondylolisthesis (HP:0003302)1.81853692
92Myositis (HP:0100614)1.81658142
93Recurrent abscess formation (HP:0002722)1.80833105
94Lip pit (HP:0100267)1.80683986
95Central scotoma (HP:0000603)1.80476131
96Hypoplastic iliac wings (HP:0002866)1.78900800
97Gastrointestinal infarctions (HP:0005244)1.78492836
98Median cleft lip (HP:0000161)1.77540409
99Primary adrenal insufficiency (HP:0008207)1.76032635
100Aplastic anemia (HP:0001915)1.75707709

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.13368625
2AKT34.11761406
3RIPK43.76870948
4CDC73.65740605
5MAP3K123.53058052
6CDK192.92532169
7FLT32.48595874
8KIT2.42306362
9FES2.36529454
10BMPR22.32134289
11MAP3K22.16600790
12PIK3CG2.13387384
13TEC2.09492631
14TAOK32.02377133
15CSF1R1.98095020
16GRK61.96752851
17CLK11.72241446
18JAK31.69225515
19ADRBK21.68624377
20PASK1.61057070
21BLK1.56932929
22MAP3K71.46674821
23MYLK1.44540707
24SYK1.32661553
25TLK11.24270905
26TNIK1.23812270
27NLK1.18719856
28PDK21.15897879
29MAP2K31.13539475
30MATK1.07610937
31TRPM71.06211729
32PRKD31.05608078
33STK241.05323276
34OXSR11.04616157
35HCK1.04210797
36TNK21.02153230
37DYRK1B1.01956946
38ZAK0.97546837
39IKBKE0.97292044
40SRPK10.95767347
41JAK10.94245967
42LCK0.92983803
43BRAF0.91645990
44LYN0.90280427
45JAK20.89370543
46BTK0.89121811
47SGK20.88299528
48ICK0.87392784
49MAP4K10.86878305
50PTK2B0.84502812
51MAP3K130.83219119
52IKBKB0.75605288
53FGR0.73758105
54CSK0.73411474
55ITK0.73057929
56FRK0.69618405
57RPS6KA50.69098648
58ADRBK10.68963639
59ERBB20.66878003
60MAP3K10.62370723
61PRKCQ0.60221751
62MAP4K20.56794896
63TYK20.52345608
64PRKG10.51912645
65DAPK30.51804837
66CAMK10.49658505
67PIM10.47591387
68IRAK10.46901651
69STK40.45596653
70PBK0.45571231
71GRK50.44935664
72SCYL20.44515585
73PTK60.43854435
74MAP3K110.43439282
75GRK70.42863740
76PRKAA20.41842353
77SGK30.40959884
78IGF1R0.40753964
79IRAK40.39778879
80DAPK10.39035607
81SGK10.39002664
82OBSCN0.37261711
83MAP2K20.36964021
84PKN10.36261596
85ILK0.35849680
86ZAP700.34809028
87ABL10.33965341
88TGFBR20.33644311
89CSNK2A20.32052986
90AURKB0.31115125
91INSRR0.30539084
92CDK60.30248381
93EIF2AK30.29667044
94MAP2K40.29559785
95EGFR0.28394169
96PAK10.27684939
97MARK30.26853577
98PRKACA0.25838001
99PRKCD0.25693234
100PRKCB0.25687617

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046726.01006560
2Asthma_Homo sapiens_hsa053104.70755340
3Allograft rejection_Homo sapiens_hsa053303.18759075
4Autoimmune thyroid disease_Homo sapiens_hsa053203.13368469
5Graft-versus-host disease_Homo sapiens_hsa053323.09057838
6Leishmaniasis_Homo sapiens_hsa051402.85244355
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.77771243
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.59056757
9Type I diabetes mellitus_Homo sapiens_hsa049402.50303723
10Staphylococcus aureus infection_Homo sapiens_hsa051502.47609323
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.32601625
12Antigen processing and presentation_Homo sapiens_hsa046122.01301345
13Sulfur metabolism_Homo sapiens_hsa009201.87276963
14Hematopoietic cell lineage_Homo sapiens_hsa046401.83643190
15Sphingolipid metabolism_Homo sapiens_hsa006001.80629495
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.76894270
17Systemic lupus erythematosus_Homo sapiens_hsa053221.70849396
18Ribosome_Homo sapiens_hsa030101.67668118
19Viral myocarditis_Homo sapiens_hsa054161.38911553
20Rheumatoid arthritis_Homo sapiens_hsa053231.36554219
21Toxoplasmosis_Homo sapiens_hsa051451.36069682
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.34247838
23Tuberculosis_Homo sapiens_hsa051521.28815756
24Chemokine signaling pathway_Homo sapiens_hsa040621.23836139
25Olfactory transduction_Homo sapiens_hsa047401.19630802
26Platelet activation_Homo sapiens_hsa046111.14536945
27African trypanosomiasis_Homo sapiens_hsa051431.10978142
28Homologous recombination_Homo sapiens_hsa034401.06466525
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.03476046
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02540069
31Herpes simplex infection_Homo sapiens_hsa051681.00229242
32Maturity onset diabetes of the young_Homo sapiens_hsa049500.97696753
33Influenza A_Homo sapiens_hsa051640.97151536
34Morphine addiction_Homo sapiens_hsa050320.96417651
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91626058
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91427990
37Primary immunodeficiency_Homo sapiens_hsa053400.91016972
38Inositol phosphate metabolism_Homo sapiens_hsa005620.90039069
39Malaria_Homo sapiens_hsa051440.89861279
40Parkinsons disease_Homo sapiens_hsa050120.88072165
41Sphingolipid signaling pathway_Homo sapiens_hsa040710.85418526
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83819064
43Oxidative phosphorylation_Homo sapiens_hsa001900.83383242
44Alcoholism_Homo sapiens_hsa050340.81399908
45Regulation of autophagy_Homo sapiens_hsa041400.80604492
46Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77147469
47Legionellosis_Homo sapiens_hsa051340.75821046
48Thyroid cancer_Homo sapiens_hsa052160.75658955
49TNF signaling pathway_Homo sapiens_hsa046680.64761776
50Osteoclast differentiation_Homo sapiens_hsa043800.62186167
51Protein export_Homo sapiens_hsa030600.62160282
52Phototransduction_Homo sapiens_hsa047440.61861483
53Salmonella infection_Homo sapiens_hsa051320.57780291
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57743657
55Huntingtons disease_Homo sapiens_hsa050160.57663628
56RNA polymerase_Homo sapiens_hsa030200.57616508
57Jak-STAT signaling pathway_Homo sapiens_hsa046300.57113298
58Measles_Homo sapiens_hsa051620.56964770
59Glycerolipid metabolism_Homo sapiens_hsa005610.55608561
60Circadian entrainment_Homo sapiens_hsa047130.55046155
61Cholinergic synapse_Homo sapiens_hsa047250.53549795
62Nucleotide excision repair_Homo sapiens_hsa034200.52957366
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52386111
64GABAergic synapse_Homo sapiens_hsa047270.52230698
65Toll-like receptor signaling pathway_Homo sapiens_hsa046200.51655512
66Phagosome_Homo sapiens_hsa041450.49884176
67Butanoate metabolism_Homo sapiens_hsa006500.49383770
68Base excision repair_Homo sapiens_hsa034100.48530857
69Basal transcription factors_Homo sapiens_hsa030220.48284672
70Tryptophan metabolism_Homo sapiens_hsa003800.47803791
71Serotonergic synapse_Homo sapiens_hsa047260.46219506
72Alzheimers disease_Homo sapiens_hsa050100.46096701
73Pyrimidine metabolism_Homo sapiens_hsa002400.45678592
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45160901
75B cell receptor signaling pathway_Homo sapiens_hsa046620.44091023
76Proteasome_Homo sapiens_hsa030500.42146456
77Long-term potentiation_Homo sapiens_hsa047200.40694902
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39243879
79Calcium signaling pathway_Homo sapiens_hsa040200.39122781
80Non-small cell lung cancer_Homo sapiens_hsa052230.37478021
81Steroid biosynthesis_Homo sapiens_hsa001000.36691541
82Fatty acid biosynthesis_Homo sapiens_hsa000610.35557742
83T cell receptor signaling pathway_Homo sapiens_hsa046600.35460390
84Renin secretion_Homo sapiens_hsa049240.32937650
85Non-homologous end-joining_Homo sapiens_hsa034500.31124546
86Purine metabolism_Homo sapiens_hsa002300.30890969
87Shigellosis_Homo sapiens_hsa051310.30518782
88Salivary secretion_Homo sapiens_hsa049700.26499206
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25432760
90Arachidonic acid metabolism_Homo sapiens_hsa005900.24384894
91Dopaminergic synapse_Homo sapiens_hsa047280.24339731
92Amphetamine addiction_Homo sapiens_hsa050310.23260325
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.22533692
94Bladder cancer_Homo sapiens_hsa052190.22292158
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22191028
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21580043
97Pertussis_Homo sapiens_hsa051330.21280705
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.19154640
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.18416495
100DNA replication_Homo sapiens_hsa030300.16962568

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