ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	maturation of SSU-rRNA (GO:0030490)	8.09631193
2	viral transcription (GO:0019083)	7.99858617
3	translational termination (GO:0006415)	7.52118216
4	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	7.02549370
5	cotranslational protein targeting to membrane (GO:0006613)	6.88701178
6	protein targeting to ER (GO:0045047)	6.82418974
7	ribosomal small subunit biogenesis (GO:0042274)	6.64096159
8	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.55837663
9	ribosomal small subunit assembly (GO:0000028)	6.49563918
10	protein localization to endoplasmic reticulum (GO:0070972)	6.38466690
11	translational elongation (GO:0006414)	6.28120490
12	cellular protein complex disassembly (GO:0043624)	5.76969121
13	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.61757628
14	viral life cycle (GO:0019058)	5.60815896
15	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.54408120
16	translational initiation (GO:0006413)	5.33776724
17	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.24884623
18	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.11613127
19	ATP synthesis coupled proton transport (GO:0015986)	5.11613127
20	protein neddylation (GO:0045116)	5.07312196
21	protein complex disassembly (GO:0043241)	4.85424962
22	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.78034971
23	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.78034971
24	NADH dehydrogenase complex assembly (GO:0010257)	4.78034971
25	respiratory electron transport chain (GO:0022904)	4.75786054
26	protein targeting to membrane (GO:0006612)	4.73237228
27	electron transport chain (GO:0022900)	4.63328028
28	macromolecular complex disassembly (GO:0032984)	4.50297361
29	translation (GO:0006412)	4.42029795
30	positive regulation of gastrulation (GO:2000543)	4.32015627
31	xenobiotic catabolic process (GO:0042178)	4.20719390
32	chaperone-mediated protein transport (GO:0072321)	4.18750922
33	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.98302833
34	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.97546403
35	cell proliferation in forebrain (GO:0021846)	3.91379990
36	mitochondrial respiratory chain complex assembly (GO:0033108)	3.91229159
37	protein complex biogenesis (GO:0070271)	3.84925166
38	artery smooth muscle contraction (GO:0014824)	3.84766525
39	mRNA catabolic process (GO:0006402)	3.79799394
40	sulfation (GO:0051923)	3.67347124
41	DNA damage response, detection of DNA damage (GO:0042769)	3.63776212
42	rRNA modification (GO:0000154)	3.55424451
43	RNA catabolic process (GO:0006401)	3.49278060
44	hydrogen ion transmembrane transport (GO:1902600)	3.41977655
45	purine deoxyribonucleotide catabolic process (GO:0009155)	3.32199865
46	ATP biosynthetic process (GO:0006754)	3.32083253
47	ribosomal large subunit biogenesis (GO:0042273)	3.31686052
48	spliceosomal snRNP assembly (GO:0000387)	3.26721474
49	negative regulation of axon extension involved in axon guidance (GO:0048843)	3.26024710
50	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.25378887
51	tonic smooth muscle contraction (GO:0014820)	3.24055073
52	water-soluble vitamin biosynthetic process (GO:0042364)	3.18802530
53	establishment of protein localization to membrane (GO:0090150)	3.17121827
54	spliceosomal complex assembly (GO:0000245)	3.16672614
55	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.15727257
56	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	3.12427418
57	GMP metabolic process (GO:0046037)	3.11699619
58	protein targeting (GO:0006605)	3.11454693
59	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.08970351
60	spinal cord association neuron differentiation (GO:0021527)	3.08789285
61	protein-cofactor linkage (GO:0018065)	3.05144620
62	aldehyde catabolic process (GO:0046185)	3.04962524
63	establishment of protein localization to organelle (GO:0072594)	3.00733605
64	sequestering of actin monomers (GO:0042989)	3.00699850
65	adenosine metabolic process (GO:0046085)	2.97517899
66	cellular component biogenesis (GO:0044085)	2.94016693
67	tongue development (GO:0043586)	2.92968985
68	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.91757514
69	nucleoside diphosphate catabolic process (GO:0009134)	2.90846883
70	proton transport (GO:0015992)	2.88256501
71	positive regulation of T cell apoptotic process (GO:0070234)	2.88187946
72	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.82283005
73	regulation of mitotic spindle checkpoint (GO:1903504)	2.82283005
74	ribonucleoprotein complex biogenesis (GO:0022613)	2.80005158
75	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.79622442
76	hydrogen transport (GO:0006818)	2.77939787
77	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.75891941
78	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.75891941
79	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.75891941
80	7-methylguanosine mRNA capping (GO:0006370)	2.73712645
81	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.73448475
82	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.73164740
83	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.73164740
84	hepatocyte differentiation (GO:0070365)	2.72394911
85	rRNA processing (GO:0006364)	2.71550707
86	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.70894737
87	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.70894737
88	deoxyribonucleotide catabolic process (GO:0009264)	2.69875201
89	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.69328802
90	L-serine metabolic process (GO:0006563)	2.68509161
91	7-methylguanosine RNA capping (GO:0009452)	2.67824919
92	RNA capping (GO:0036260)	2.67824919
93	negative regulation of axon guidance (GO:1902668)	2.67310790
94	negative regulation of ligase activity (GO:0051352)	2.67125660
95	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.67125660
96	response to redox state (GO:0051775)	2.62569150
97	replicative senescence (GO:0090399)	2.58193885
98	rRNA metabolic process (GO:0016072)	2.57849098
99	regulation of cardioblast differentiation (GO:0051890)	2.57631743
100	positive regulation of fatty acid oxidation (GO:0046321)	2.56824054

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	8.65858632
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.75150453
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.93639303
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	4.90675776
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.34947061
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.91066785
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.75795880
8	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.99213225
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.92587243
10	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.86147635
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.84875377
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.82333056
13	ELK1_19687146_ChIP-ChIP_HELA_Human	2.80737219
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.69333238
15	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.63901041
16	MYC_18940864_ChIP-ChIP_HL60_Human	2.50636574
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.30335687
18	TTF2_22483619_ChIP-Seq_HELA_Human	2.17100409
19	EZH2_22144423_ChIP-Seq_EOC_Human	2.14174108
20	ZNF274_21170338_ChIP-Seq_K562_Hela	1.98485556
21	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.92073948
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.91401978
23	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.84165375
24	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.83907504
25	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.80497175
26	VDR_22108803_ChIP-Seq_LS180_Human	1.78778678
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.76527765
28	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.75819167
29	DCP1A_22483619_ChIP-Seq_HELA_Human	1.75754977
30	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.74685886
31	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.73890917
32	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.69944271
33	IRF1_19129219_ChIP-ChIP_H3396_Human	1.69319684
34	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.68670718
35	EWS_26573619_Chip-Seq_HEK293_Human	1.67758737
36	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.67404474
37	XRN2_22483619_ChIP-Seq_HELA_Human	1.58623741
38	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.52857980
39	FUS_26573619_Chip-Seq_HEK293_Human	1.50657359
40	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.50240303
41	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.49231141
42	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.47225319
43	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.44559291
44	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.42312303
45	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.41630242
46	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.38835766
47	TAF15_26573619_Chip-Seq_HEK293_Human	1.34532362
48	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.33948084
49	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.33868742
50	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.32489669
51	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.29504161
52	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.28165364
53	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.24625425
54	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.20293840
55	GABP_19822575_ChIP-Seq_HepG2_Human	1.18557955
56	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.17905215
57	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.14886729
58	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.12180589
59	TP53_22573176_ChIP-Seq_HFKS_Human	1.08939012
60	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.08102951
61	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.07696535
62	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.05816592
63	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.05051558
64	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.01276474
65	ERG_20517297_ChIP-Seq_VCAP_Human	1.01141166
66	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.97886402
67	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.95697771
68	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.94754224
69	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.93119556
70	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.92476518
71	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.92326315
72	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.92326315
73	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.91826884
74	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.90838534
75	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.90259346
76	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.90074864
77	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.90020649
78	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.87805645
79	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.84216288
80	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.83153858
81	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.82196872
82	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.81774357
83	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.81096132
84	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.79146043
85	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.77619887
86	CBP_20019798_ChIP-Seq_JUKART_Human	0.77091665
87	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.77091665
88	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.76902718
89	AR_20517297_ChIP-Seq_VCAP_Human	0.76146296
90	P300_19829295_ChIP-Seq_ESCs_Human	0.75937702
91	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.74536695
92	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.73336155
93	BCAT_22108803_ChIP-Seq_LS180_Human	0.72617223
94	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.72032201
95	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.71040236
96	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.70574375
97	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.69838261
98	FOXM1_23109430_ChIP-Seq_U2OS_Human	0.68569252
99	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.66682268
100	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.65934310

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.16788457
2	MP0002938_white_spotting	3.45305994
3	MP0006072_abnormal_retinal_apoptosis	2.99322270
4	MP0004145_abnormal_muscle_electrophysio	2.87772692
5	MP0002653_abnormal_ependyma_morphology	2.71646027
6	MP0010030_abnormal_orbit_morphology	2.62347277
7	MP0001485_abnormal_pinna_reflex	2.58413994
8	MP0006292_abnormal_olfactory_placode	2.52530394
9	MP0008875_abnormal_xenobiotic_pharmacok	2.52334722
10	MP0000566_synostosis	2.24525524
11	MP0002277_abnormal_respiratory_mucosa	2.15034502
12	MP0003786_premature_aging	2.07961623
13	MP0003806_abnormal_nucleotide_metabolis	2.06870508
14	MP0003186_abnormal_redox_activity	1.97748873
15	MP0001293_anophthalmia	1.96604941
16	MP0001346_abnormal_lacrimal_gland	1.95983530
17	MP0005253_abnormal_eye_physiology	1.93318520
18	MP0002282_abnormal_trachea_morphology	1.91010231
19	MP0001835_abnormal_antigen_presentation	1.88688957
20	MP0005671_abnormal_response_to	1.78371310
21	MP0003941_abnormal_skin_development	1.67637592
22	MP0004142_abnormal_muscle_tone	1.67347118
23	MP0000049_abnormal_middle_ear	1.64201517
24	MP0000631_abnormal_neuroendocrine_gland	1.53837179
25	MP0008872_abnormal_physiological_respon	1.48849724
26	MP0005332_abnormal_amino_acid	1.43569787
27	MP0009250_abnormal_appendicular_skeleto	1.43198052
28	MP0003937_abnormal_limbs/digits/tail_de	1.40756816
29	MP0005645_abnormal_hypothalamus_physiol	1.38550166
30	MP0008007_abnormal_cellular_replicative	1.36832221
31	MP0002876_abnormal_thyroid_physiology	1.32500159
32	MP0004133_heterotaxia	1.32161347
33	MP0004885_abnormal_endolymph	1.31054528
34	MP0003567_abnormal_fetal_cardiomyocyte	1.30592451
35	MP0005503_abnormal_tendon_morphology	1.30576800
36	MP0000026_abnormal_inner_ear	1.24606795
37	MP0004742_abnormal_vestibular_system	1.21585426
38	MP0002132_abnormal_respiratory_system	1.20997543
39	MP0002163_abnormal_gland_morphology	1.19725103
40	MP0002089_abnormal_postnatal_growth/wei	1.18454951
41	MP0000685_abnormal_immune_system	1.17090309
42	MP0001727_abnormal_embryo_implantation	1.14767827
43	MP0005391_vision/eye_phenotype	1.13673528
44	MP0003252_abnormal_bile_duct	1.13371191
45	MP0005367_renal/urinary_system_phenotyp	1.12348471
46	MP0000516_abnormal_urinary_system	1.12348471
47	MP0003646_muscle_fatigue	1.11853689
48	MP0004957_abnormal_blastocyst_morpholog	1.10968290
49	MP0001905_abnormal_dopamine_level	1.10686247
50	MP0010094_abnormal_chromosome_stability	1.10266185
51	MP0009785_altered_susceptibility_to	1.09838365
52	MP0008058_abnormal_DNA_repair	1.09760897
53	MP0001529_abnormal_vocalization	1.08705042
54	MP0001756_abnormal_urination	1.05310228
55	MP0001984_abnormal_olfaction	1.04858973
56	MP0009764_decreased_sensitivity_to	1.04844938
57	MP0003718_maternal_effect	1.04559729
58	MP0003938_abnormal_ear_development	1.01733408
59	MP0001963_abnormal_hearing_physiology	1.00940713
60	MP0002837_dystrophic_cardiac_calcinosis	0.99354808
61	MP0002102_abnormal_ear_morphology	0.95665446
62	MP0001986_abnormal_taste_sensitivity	0.93376182
63	MP0005551_abnormal_eye_electrophysiolog	0.93206873
64	MP0003011_delayed_dark_adaptation	0.92870900
65	MP0002095_abnormal_skin_pigmentation	0.92009301
66	MP0002138_abnormal_hepatobiliary_system	0.90840637
67	MP0000613_abnormal_salivary_gland	0.90734463
68	MP0003283_abnormal_digestive_organ	0.90306861
69	MP0002090_abnormal_vision	0.89190846
70	MP0002234_abnormal_pharynx_morphology	0.88931958
71	MP0005408_hypopigmentation	0.87488898
72	MP0005389_reproductive_system_phenotype	0.87366341
73	MP0003880_abnormal_central_pattern	0.86874149
74	MP0003195_calcinosis	0.85915776
75	MP0000163_abnormal_cartilage_morphology	0.85482639
76	MP0002160_abnormal_reproductive_system	0.85393050
77	MP0001486_abnormal_startle_reflex	0.85191063
78	MP0005075_abnormal_melanosome_morpholog	0.84595800
79	MP0001881_abnormal_mammary_gland	0.82957890
80	MP0008877_abnormal_DNA_methylation	0.82386025
81	MP0005379_endocrine/exocrine_gland_phen	0.80350557
82	MP0008057_abnormal_DNA_replication	0.80272912
83	MP0001299_abnormal_eye_distance/	0.80174903
84	MP0000647_abnormal_sebaceous_gland	0.79534497
85	MP0000372_irregular_coat_pigmentation	0.77491666
86	MP0003077_abnormal_cell_cycle	0.77478831
87	MP0004134_abnormal_chest_morphology	0.77408271
88	MP0002006_tumorigenesis	0.76180906
89	MP0000537_abnormal_urethra_morphology	0.75924084
90	MP0002272_abnormal_nervous_system	0.75825453
91	MP0008789_abnormal_olfactory_epithelium	0.75732418
92	MP0003121_genomic_imprinting	0.73853828
93	MP0000569_abnormal_digit_pigmentation	0.73838625
94	MP0001145_abnormal_male_reproductive	0.73777780
95	MP0005266_abnormal_metabolism	0.71258775
96	MP0002697_abnormal_eye_size	0.71176039
97	MP0009765_abnormal_xenobiotic_induced	0.70460355
98	MP0000358_abnormal_cell_content/	0.70148885
99	MP0008995_early_reproductive_senescence	0.69124133
100	MP0003136_yellow_coat_color	0.68723468

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.99684166
2	Hepatocellular necrosis (HP:0001404)	5.36591644
3	Hepatic necrosis (HP:0002605)	5.34863979
4	Pancreatic fibrosis (HP:0100732)	4.84479856
5	Acute necrotizing encephalopathy (HP:0006965)	4.83768182
6	Pancreatic cysts (HP:0001737)	4.49401638
7	Mitochondrial inheritance (HP:0001427)	4.42528619
8	True hermaphroditism (HP:0010459)	4.24513648
9	Acute encephalopathy (HP:0006846)	4.19544586
10	Abnormal mitochondria in muscle tissue (HP:0008316)	4.07119729
11	Abnormality of midbrain morphology (HP:0002418)	3.97019118
12	Molar tooth sign on MRI (HP:0002419)	3.97019118
13	Progressive macrocephaly (HP:0004481)	3.80204850
14	Sclerocornea (HP:0000647)	3.75023164
15	Macrocytic anemia (HP:0001972)	3.54563498
16	Abnormal number of erythroid precursors (HP:0012131)	3.51169296
17	Abnormality of cells of the erythroid lineage (HP:0012130)	3.49949863
18	Congenital, generalized hypertrichosis (HP:0004540)	3.46773850
19	Increased CSF lactate (HP:0002490)	3.41455372
20	Cerebral edema (HP:0002181)	3.08766794
21	Cystic liver disease (HP:0006706)	3.07995984
22	Pallor (HP:0000980)	2.98807921
23	Cheilitis (HP:0100825)	2.98796483
24	Septo-optic dysplasia (HP:0100842)	2.95019420
25	Generalized aminoaciduria (HP:0002909)	2.85893745
26	Occipital encephalocele (HP:0002085)	2.84861869
27	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.82962910
28	Congenital hepatic fibrosis (HP:0002612)	2.79368060
29	Carpal bone hypoplasia (HP:0001498)	2.69718760
30	Concave nail (HP:0001598)	2.67395136
31	Woolly hair (HP:0002224)	2.60766771
32	Anencephaly (HP:0002323)	2.58927123
33	Abnormality of DNA repair (HP:0003254)	2.54836339
34	IgG deficiency (HP:0004315)	2.53001651
35	Methylmalonic acidemia (HP:0002912)	2.45506891
36	Hyperventilation (HP:0002883)	2.44460355
37	Humeroradial synostosis (HP:0003041)	2.41532873
38	Synostosis involving the elbow (HP:0003938)	2.41532873
39	Coronal craniosynostosis (HP:0004440)	2.39060570
40	CNS demyelination (HP:0007305)	2.37530809
41	Abolished electroretinogram (ERG) (HP:0000550)	2.36289346
42	Hyperglycinemia (HP:0002154)	2.36254604
43	Stenosis of the external auditory canal (HP:0000402)	2.32352195
44	Respiratory failure (HP:0002878)	2.29774562
45	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.28849000
46	Depressed nasal ridge (HP:0000457)	2.28448186
47	Confusion (HP:0001289)	2.25423480
48	Bile duct proliferation (HP:0001408)	2.24861551
49	Abnormal biliary tract physiology (HP:0012439)	2.24861551
50	Tachypnea (HP:0002789)	2.24452558
51	Hypoplastic pelvis (HP:0008839)	2.24290114
52	Chronic hepatic failure (HP:0100626)	2.22296563
53	Nephronophthisis (HP:0000090)	2.17594592
54	Hypoglycemic coma (HP:0001325)	2.17022127
55	Male pseudohermaphroditism (HP:0000037)	2.16875839
56	Furrowed tongue (HP:0000221)	2.14003793
57	3-Methylglutaconic aciduria (HP:0003535)	2.12951273
58	Absent septum pellucidum (HP:0001331)	2.11750762
59	Lipid accumulation in hepatocytes (HP:0006561)	2.10169038
60	Lactic acidosis (HP:0003128)	2.08496103
61	Intellectual disability, moderate (HP:0002342)	2.08441013
62	Increased hepatocellular lipid droplets (HP:0006565)	2.06662053
63	Abnormal hemoglobin (HP:0011902)	2.03574938
64	Retinal dysplasia (HP:0007973)	2.02445501
65	Porencephaly (HP:0002132)	2.00239242
66	Ulnar deviation of the wrist (HP:0003049)	1.97654011
67	Bilateral microphthalmos (HP:0007633)	1.97153778
68	Emotional lability (HP:0000712)	1.96284576
69	Oral leukoplakia (HP:0002745)	1.96217793
70	Partial duplication of the phalanx of hand (HP:0009999)	1.95560693
71	Lethargy (HP:0001254)	1.94383934
72	Microvesicular hepatic steatosis (HP:0001414)	1.94087014
73	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.94064940
74	Preaxial hand polydactyly (HP:0001177)	1.93488944
75	Abnormality of the renal collecting system (HP:0004742)	1.91835433
76	Leukodystrophy (HP:0002415)	1.91356673
77	Postaxial foot polydactyly (HP:0001830)	1.90580591
78	Nasolacrimal duct obstruction (HP:0000579)	1.89894796
79	Partial duplication of thumb phalanx (HP:0009944)	1.88741457
80	Abnormality of the renal cortex (HP:0011035)	1.88250504
81	Optic disc pallor (HP:0000543)	1.87959805
82	Renal cortical cysts (HP:0000803)	1.86551751
83	Duplicated collecting system (HP:0000081)	1.85532736
84	Tubular atrophy (HP:0000092)	1.84013671
85	Decreased subcutaneous fat (HP:0001002)	1.79856316
86	Facial cleft (HP:0002006)	1.78870724
87	Bifid tongue (HP:0010297)	1.77353827
88	Abnormal lung lobation (HP:0002101)	1.76686123
89	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.76443512
90	Methylmalonic aciduria (HP:0012120)	1.75521107
91	Dry hair (HP:0011359)	1.74683254
92	Irregular epiphyses (HP:0010582)	1.73552997
93	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.73388078
94	Dicarboxylic aciduria (HP:0003215)	1.73388078
95	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.70960761
96	Exercise intolerance (HP:0003546)	1.70610340
97	Sloping forehead (HP:0000340)	1.70609020
98	Abnormality of the renal medulla (HP:0100957)	1.69611993
99	Abnormality of renal resorption (HP:0011038)	1.69568996
100	Increased serum lactate (HP:0002151)	1.68795704

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	6.27889504
2	ZAK	3.83203615
3	TLK1	3.56072931
4	VRK1	3.22214177
5	MAP3K12	3.02479720
6	NME1	2.78176763
7	BMPR2	2.60418078
8	TAF1	2.56197974
9	MYLK	2.38181267
10	NEK1	2.18279996
11	NUAK1	2.14766946
12	DAPK3	2.13620084
13	STK16	2.05480639
14	SRPK1	2.03279528
15	BUB1	1.99242806
16	ERBB3	1.94701814
17	FLT3	1.86589207
18	TNIK	1.84359180
19	EPHA4	1.79473840
20	CDK19	1.77190019
21	TRIM28	1.54332300
22	STK39	1.52850218
23	GRK1	1.48776039
24	LATS1	1.42688448
25	PASK	1.42466814
26	NME2	1.26442376
27	STK38L	1.21945204
28	MAP4K2	1.17727909
29	CSF1R	1.13513687
30	TTK	1.08700571
31	PAK4	1.07836859
32	PAK6	1.07400130
33	DYRK2	0.99358389
34	ILK	0.95880288
35	BCKDK	0.95851040
36	WNK4	0.88992099
37	ADRBK2	0.86813213
38	AURKA	0.85834658
39	MOS	0.85818744
40	SMG1	0.82541729
41	PRKD2	0.81766730
42	STK24	0.79816329
43	MST4	0.78772816
44	CCNB1	0.78714215
45	AURKB	0.75978796
46	WNK3	0.75583324
47	CDC7	0.74989907
48	PLK3	0.74831579
49	ROCK1	0.73546885
50	STK3	0.72585493
51	EPHB2	0.70789395
52	WEE1	0.70377210
53	ATR	0.70033681
54	PAK3	0.69904919
55	PLK4	0.68159809
56	CSNK1G3	0.64625003
57	CDK7	0.63390169
58	GRK5	0.63170413
59	NEK9	0.61732020
60	CSNK1G1	0.59158738
61	CHEK2	0.58374048
62	ADRBK1	0.58138144
63	GRK7	0.55822985
64	TXK	0.55130023
65	RPS6KA5	0.54866181
66	MAP3K4	0.53931476
67	DAPK1	0.53358155
68	CSNK1A1L	0.53090285
69	PLK1	0.51869357
70	ROCK2	0.51747067
71	TGFBR1	0.51570047
72	OBSCN	0.50015912
73	LIMK1	0.49520658
74	CDK12	0.47700233
75	CDK3	0.47647841
76	CSNK2A2	0.44786766
77	IGF1R	0.44658357
78	TRPM7	0.44091498
79	CSNK2A1	0.42107569
80	TIE1	0.41331789
81	INSRR	0.41169131
82	CSNK1A1	0.40758206
83	BMPR1B	0.38092855
84	IKBKB	0.37887063
85	PRKCE	0.36914923
86	CAMK2D	0.36856545
87	NLK	0.35117683
88	MAP3K8	0.34681091
89	CDK11A	0.33984504
90	MAPKAPK5	0.33755043
91	NEK2	0.33489037
92	KIT	0.31800013
93	MAP4K1	0.30479918
94	PAK1	0.29523919
95	PINK1	0.28888571
96	FRK	0.28401516
97	FGFR2	0.28350077
98	EIF2AK2	0.26680251
99	PRKG1	0.26461730
100	PRKACA	0.26313686

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.87667835
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.72416697
3	Parkinsons disease_Homo sapiens_hsa05012	3.78240317
4	Proteasome_Homo sapiens_hsa03050	3.66682519
5	Protein export_Homo sapiens_hsa03060	3.06459419
6	Systemic lupus erythematosus_Homo sapiens_hsa05322	3.01917046
7	Huntingtons disease_Homo sapiens_hsa05016	2.81217583
8	Alzheimers disease_Homo sapiens_hsa05010	2.79760225
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.69477253
10	Cardiac muscle contraction_Homo sapiens_hsa04260	2.51191519
11	Sulfur metabolism_Homo sapiens_hsa00920	2.22639160
12	Asthma_Homo sapiens_hsa05310	2.15457681
13	DNA replication_Homo sapiens_hsa03030	2.03089184
14	Homologous recombination_Homo sapiens_hsa03440	2.02659749
15	Base excision repair_Homo sapiens_hsa03410	1.95705657
16	RNA polymerase_Homo sapiens_hsa03020	1.76942688
17	Nucleotide excision repair_Homo sapiens_hsa03420	1.66426003
18	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.65510898
19	RNA degradation_Homo sapiens_hsa03018	1.58133866
20	Alcoholism_Homo sapiens_hsa05034	1.52058205
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.51742820
22	Non-homologous end-joining_Homo sapiens_hsa03450	1.44040766
23	Spliceosome_Homo sapiens_hsa03040	1.38737041
24	Allograft rejection_Homo sapiens_hsa05330	1.38260999
25	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.37529096
26	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.20512177
27	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.20420712
28	Basal cell carcinoma_Homo sapiens_hsa05217	1.14053052
29	Basal transcription factors_Homo sapiens_hsa03022	1.12616615
30	RNA transport_Homo sapiens_hsa03013	1.09537872
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.07287472
32	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.03862185
33	Graft-versus-host disease_Homo sapiens_hsa05332	1.02715591
34	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.01599119
35	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.99795810
36	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.98226883
37	Glutathione metabolism_Homo sapiens_hsa00480	0.96214584
38	Mismatch repair_Homo sapiens_hsa03430	0.95434347
39	Chemical carcinogenesis_Homo sapiens_hsa05204	0.95314785
40	Type I diabetes mellitus_Homo sapiens_hsa04940	0.92643143
41	Purine metabolism_Homo sapiens_hsa00230	0.89954005
42	Nitrogen metabolism_Homo sapiens_hsa00910	0.82480857
43	Tryptophan metabolism_Homo sapiens_hsa00380	0.81382239
44	Propanoate metabolism_Homo sapiens_hsa00640	0.81018767
45	Primary immunodeficiency_Homo sapiens_hsa05340	0.78642070
46	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.76824041
47	Selenocompound metabolism_Homo sapiens_hsa00450	0.74565705
48	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.72708456
49	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.69274071
50	Pyrimidine metabolism_Homo sapiens_hsa00240	0.69024336
51	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.67384467
52	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.67361843
53	Fanconi anemia pathway_Homo sapiens_hsa03460	0.65047221
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.63948996
55	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.63324047
56	One carbon pool by folate_Homo sapiens_hsa00670	0.62954678
57	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.62677499
58	Rheumatoid arthritis_Homo sapiens_hsa05323	0.61941422
59	Metabolic pathways_Homo sapiens_hsa01100	0.58707898
60	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.58397785
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.57923156
62	Antigen processing and presentation_Homo sapiens_hsa04612	0.49511867
63	Collecting duct acid secretion_Homo sapiens_hsa04966	0.48016964
64	Circadian rhythm_Homo sapiens_hsa04710	0.46349293
65	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.45981483
66	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.45373801
67	p53 signaling pathway_Homo sapiens_hsa04115	0.44218177
68	Viral myocarditis_Homo sapiens_hsa05416	0.43882350
69	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.43469864
70	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.41377633
71	Regulation of autophagy_Homo sapiens_hsa04140	0.41225742
72	Sulfur relay system_Homo sapiens_hsa04122	0.40735976
73	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.38855012
74	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.38594590
75	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.37204447
76	beta-Alanine metabolism_Homo sapiens_hsa00410	0.36206439
77	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.35910485
78	Retinol metabolism_Homo sapiens_hsa00830	0.34758626
79	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.34398752
80	Viral carcinogenesis_Homo sapiens_hsa05203	0.32491427
81	Hippo signaling pathway_Homo sapiens_hsa04390	0.32262960
82	Linoleic acid metabolism_Homo sapiens_hsa00591	0.31502600
83	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.31332613
84	Peroxisome_Homo sapiens_hsa04146	0.28056170
85	Cell cycle_Homo sapiens_hsa04110	0.26795747
86	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.26776062
87	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.26119410
88	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.25813851
89	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.25468611
90	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.24900871
91	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.24691142
92	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.24264749
93	Tyrosine metabolism_Homo sapiens_hsa00350	0.24100243
94	Carbon metabolism_Homo sapiens_hsa01200	0.20216823
95	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.20070025
96	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.19993086
97	Fat digestion and absorption_Homo sapiens_hsa04975	0.19746341
98	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.19107061
99	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.17362961
100	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.16791013

KCTD9P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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