ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	platelet dense granule organization (GO:0060155)	5.23317456
2	regulation of secondary heart field cardioblast proliferation (GO:0003266)	5.02072412
3	regulation of cardioblast proliferation (GO:0003264)	5.02072412
4	intestinal epithelial cell development (GO:0060576)	5.01255934
5	response to pheromone (GO:0019236)	4.83356822
6	nephron epithelium morphogenesis (GO:0072088)	4.74340540
7	nephron tubule morphogenesis (GO:0072078)	4.74340540
8	cellular response to nicotine (GO:0071316)	4.60814278
9	energy homeostasis (GO:0097009)	4.54090106
10	cellular ketone body metabolic process (GO:0046950)	4.52675924
11	negative regulation of cytosolic calcium ion concentration (GO:0051481)	4.50768582
12	regulation of cardioblast differentiation (GO:0051890)	4.22819647
13	ketone body metabolic process (GO:1902224)	4.08422333
14	cardiac ventricle formation (GO:0003211)	4.04795342
15	establishment of protein localization to Golgi (GO:0072600)	3.99926954
16	protein targeting to Golgi (GO:0000042)	3.98826975
17	retina layer formation (GO:0010842)	3.95823245
18	water-soluble vitamin biosynthetic process (GO:0042364)	3.91675415
19	pericardium development (GO:0060039)	3.83876658
20	cardiac chamber formation (GO:0003207)	3.81551713
21	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.63157251
22	renal tubule morphogenesis (GO:0061333)	3.52774856
23	regulation of skeletal muscle contraction (GO:0014819)	3.52682875
24	atrial septum morphogenesis (GO:0060413)	3.51479715
25	regulation of glucokinase activity (GO:0033131)	3.40855854
26	regulation of hexokinase activity (GO:1903299)	3.40855854
27	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.32662319
28	endocardial cushion development (GO:0003197)	3.24437429
29	basement membrane organization (GO:0071711)	3.20978835
30	nephron tubule formation (GO:0072079)	3.19957096
31	endocrine pancreas development (GO:0031018)	3.16035824
32	endosome to pigment granule transport (GO:0043485)	3.14668852
33	endosome to melanosome transport (GO:0035646)	3.14668852
34	intra-Golgi vesicle-mediated transport (GO:0006891)	3.14020030
35	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.12100540
36	inositol phosphate dephosphorylation (GO:0046855)	3.12100540
37	keratan sulfate catabolic process (GO:0042340)	3.11352276
38	negative regulation of telomere maintenance (GO:0032205)	3.11069354
39	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.10717770
40	photoreceptor cell maintenance (GO:0045494)	3.08946730
41	potassium ion import (GO:0010107)	3.06032715
42	macroautophagy (GO:0016236)	3.02876251
43	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.01776317
44	regulation of neurotransmitter uptake (GO:0051580)	3.00113180
45	negative regulation of metanephros development (GO:0072217)	2.99570807
46	inositol phosphate catabolic process (GO:0071545)	2.98958287
47	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	2.97313319
48	protein localization to Golgi apparatus (GO:0034067)	2.96771364
49	acrosome reaction (GO:0007340)	2.96064405
50	detection of light stimulus involved in sensory perception (GO:0050962)	2.93195978
51	detection of light stimulus involved in visual perception (GO:0050908)	2.93195978
52	kidney morphogenesis (GO:0060993)	2.90244336
53	response to ischemia (GO:0002931)	2.89982337
54	regulation of execution phase of apoptosis (GO:1900117)	2.86947364
55	retinal cone cell development (GO:0046549)	2.81813660
56	pancreas development (GO:0031016)	2.79927562
57	rRNA catabolic process (GO:0016075)	2.76663263
58	organ formation (GO:0048645)	2.74456010
59	negative regulation of cAMP-mediated signaling (GO:0043951)	2.73634473
60	cell migration involved in heart development (GO:0060973)	2.71240676
61	regulation of cell proliferation involved in kidney development (GO:1901722)	2.70715155
62	single strand break repair (GO:0000012)	2.70344653
63	positive regulation of meiotic cell cycle (GO:0051446)	2.70119160
64	hindbrain development (GO:0030902)	2.69683598
65	atrioventricular valve morphogenesis (GO:0003181)	2.67993127
66	nitric oxide biosynthetic process (GO:0006809)	2.67006218
67	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	2.66236583
68	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.65053806
69	deoxyribonucleoside diphosphate metabolic process (GO:0009186)	2.64174511
70	pyrimidine dimer repair (GO:0006290)	2.63345630
71	homocysteine metabolic process (GO:0050667)	2.60480363
72	nitric oxide mediated signal transduction (GO:0007263)	2.56983637
73	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.56096517
74	bone mineralization (GO:0030282)	2.56069054
75	regulation of heart rate by cardiac conduction (GO:0086091)	2.54241754
76	relaxation of cardiac muscle (GO:0055119)	2.52912764
77	auditory receptor cell differentiation (GO:0042491)	2.50639422
78	polyol catabolic process (GO:0046174)	2.50387196
79	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.49730337
80	cellular response to alkaloid (GO:0071312)	2.48751388
81	regulation of cell proliferation involved in heart morphogenesis (GO:2000136)	2.46619986
82	peptidyl-histidine modification (GO:0018202)	2.46301703
83	protein deneddylation (GO:0000338)	2.44617887
84	regulation of action potential (GO:0098900)	2.44331221
85	protein import into peroxisome matrix (GO:0016558)	2.42495941
86	inner ear receptor stereocilium organization (GO:0060122)	2.40127054
87	protein neddylation (GO:0045116)	2.38998378
88	telomere maintenance via telomerase (GO:0007004)	2.38877356
89	collagen fibril organization (GO:0030199)	2.35274916
90	negative regulation of JUN kinase activity (GO:0043508)	2.34432869
91	secretory granule organization (GO:0033363)	2.34243300
92	basic amino acid transport (GO:0015802)	2.33904947
93	negative regulation of hormone biosynthetic process (GO:0032353)	2.33848462
94	cardiac conduction (GO:0061337)	2.33555706
95	protein targeting to lysosome (GO:0006622)	2.33353507
96	establishment of protein localization to vacuole (GO:0072666)	2.33353507
97	protein targeting to vacuole (GO:0006623)	2.33353507
98	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.32496653
99	anterograde synaptic vesicle transport (GO:0048490)	2.32469880
100	keratinocyte development (GO:0003334)	2.31203601

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.36391015
2	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.74735602
3	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.69295458
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.58871376
5	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.52688057
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.46203157
7	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.43829243
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.26973791
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.25685668
10	VDR_22108803_ChIP-Seq_LS180_Human	2.17992548
11	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.05424250
12	GBX2_23144817_ChIP-Seq_PC3_Human	1.97196952
13	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.86292086
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.82823347
15	P300_19829295_ChIP-Seq_ESCs_Human	1.80197707
16	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.79026835
17	CBP_20019798_ChIP-Seq_JUKART_Human	1.76356374
18	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.76356374
19	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.76340991
20	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.70614755
21	EWS_26573619_Chip-Seq_HEK293_Human	1.70553447
22	SMAD4_21799915_ChIP-Seq_A2780_Human	1.67062430
23	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.65357510
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.65222992
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.64647758
26	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.62699635
27	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.62484673
28	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.62084331
29	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.61585006
30	AR_25329375_ChIP-Seq_VCAP_Human	1.60793171
31	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.60738033
32	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.59307621
33	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.50396859
34	STAT3_23295773_ChIP-Seq_U87_Human	1.47774032
35	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.47664231
36	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.46661903
37	ER_23166858_ChIP-Seq_MCF-7_Human	1.44787878
38	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.43970733
39	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.43747553
40	FUS_26573619_Chip-Seq_HEK293_Human	1.43130121
41	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.42214397
42	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.39370178
43	BCAT_22108803_ChIP-Seq_LS180_Human	1.39143212
44	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38323016
45	IGF1R_20145208_ChIP-Seq_DFB_Human	1.38064852
46	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.37398209
47	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.37249362
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35570757
49	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.35358538
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.33116939
51	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.32569841
52	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.32569841
53	RNF2_27304074_Chip-Seq_NSC_Mouse	1.32315640
54	TCF4_23295773_ChIP-Seq_U87_Human	1.32240231
55	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.31952514
56	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.31154478
57	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.30518276
58	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.27308117
59	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.26736856
60	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.26627668
61	TCF4_22108803_ChIP-Seq_LS180_Human	1.26402734
62	TP53_18474530_ChIP-ChIP_U2OS_Human	1.25877822
63	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.25797491
64	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.25621327
65	AR_20517297_ChIP-Seq_VCAP_Human	1.25012173
66	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.24592248
67	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24441057
68	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.24314973
69	CDX2_22108803_ChIP-Seq_LS180_Human	1.24129756
70	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.23491630
71	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.23078421
72	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.20730056
73	HTT_18923047_ChIP-ChIP_STHdh_Human	1.19616195
74	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.19070725
75	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.17701156
76	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.17350266
77	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.16902866
78	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16604435
79	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16604435
80	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.16407190
81	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.15908284
82	TAF15_26573619_Chip-Seq_HEK293_Human	1.12123567
83	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10638815
84	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.09656044
85	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09645124
86	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.09214606
87	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.08760687
88	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.08662054
89	P53_22387025_ChIP-Seq_ESCs_Mouse	1.08411117
90	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.08314420
91	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.07624164
92	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.07214316
93	NFYB_21822215_ChIP-Seq_K562_Human	1.06872553
94	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.06503427
95	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.05164832
96	TBL1_22424771_ChIP-Seq_293T_Human	1.02236589
97	TP53_22573176_ChIP-Seq_HFKS_Human	0.99975635
98	RUNX2_22187159_ChIP-Seq_PCA_Human	0.99707677
99	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.99215617
100	PHF8_20622853_ChIP-Seq_HELA_Human	0.98499733

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003283_abnormal_digestive_organ	5.34935846
2	MP0002138_abnormal_hepatobiliary_system	5.17464085
3	MP0009780_abnormal_chondrocyte_physiolo	4.72259840
4	MP0005503_abnormal_tendon_morphology	4.36336145
5	MP0002139_abnormal_hepatobiliary_system	3.16607432
6	MP0005275_abnormal_skin_tensile	3.08032398
7	MP0002254_reproductive_system_inflammat	3.00785096
8	MP0006072_abnormal_retinal_apoptosis	2.58164547
9	MP0005257_abnormal_intraocular_pressure	2.41566506
10	MP0005084_abnormal_gallbladder_morpholo	2.37719721
11	MP0003137_abnormal_impulse_conducting	2.20680382
12	MP0005253_abnormal_eye_physiology	2.18637193
13	MP0000372_irregular_coat_pigmentation	2.01970247
14	MP0002102_abnormal_ear_morphology	2.00323933
15	MP0004134_abnormal_chest_morphology	1.95702018
16	MP0003195_calcinosis	1.94551091
17	MP0001529_abnormal_vocalization	1.90948417
18	MP0000383_abnormal_hair_follicle	1.89525383
19	MP0010678_abnormal_skin_adnexa	1.77796033
20	MP0002876_abnormal_thyroid_physiology	1.77016958
21	MP0004215_abnormal_myocardial_fiber	1.74640625
22	MP0002837_dystrophic_cardiac_calcinosis	1.68607770
23	MP0005646_abnormal_pituitary_gland	1.66817330
24	MP0000462_abnormal_digestive_system	1.64783003
25	MP0005248_abnormal_Harderian_gland	1.59018205
26	MP0005377_hearing/vestibular/ear_phenot	1.56347839
27	MP0003878_abnormal_ear_physiology	1.56347839
28	MP0005551_abnormal_eye_electrophysiolog	1.54613143
29	MP0002938_white_spotting	1.48216477
30	MP0000427_abnormal_hair_cycle	1.47078367
31	MP0002693_abnormal_pancreas_physiology	1.46241970
32	MP0003279_aneurysm	1.45918006
33	MP0004043_abnormal_pH_regulation	1.42482785
34	MP0001944_abnormal_pancreas_morphology	1.40965507
35	MP0008877_abnormal_DNA_methylation	1.40140226
36	MP0009046_muscle_twitch	1.38490088
37	MP0005075_abnormal_melanosome_morpholog	1.38137095
38	MP0002909_abnormal_adrenal_gland	1.38072747
39	MP0002653_abnormal_ependyma_morphology	1.31800487
40	MP0010234_abnormal_vibrissa_follicle	1.29576617
41	MP0005174_abnormal_tail_pigmentation	1.24025797
42	MP0004085_abnormal_heartbeat	1.23783174
43	MP0006036_abnormal_mitochondrial_physio	1.23192802
44	MP0009250_abnormal_appendicular_skeleto	1.22761031
45	MP0002108_abnormal_muscle_morphology	1.22043342
46	MP0003868_abnormal_feces_composition	1.20747776
47	MP0005367_renal/urinary_system_phenotyp	1.17628596
48	MP0000516_abnormal_urinary_system	1.17628596
49	MP0002295_abnormal_pulmonary_circulatio	1.16670143
50	MP0003122_maternal_imprinting	1.16329480
51	MP0001324_abnormal_eye_pigmentation	1.15115146
52	MP0005508_abnormal_skeleton_morphology	1.13622943
53	MP0003787_abnormal_imprinting	1.12773729
54	MP0006054_spinal_hemorrhage	1.12261709
55	MP0000003_abnormal_adipose_tissue	1.09781029
56	MP0002751_abnormal_autonomic_nervous	1.07972784
57	MP0000613_abnormal_salivary_gland	1.07943316
58	MP0005332_abnormal_amino_acid	1.06688289
59	MP0004883_abnormal_blood_vessel	1.00905994
60	MP0010030_abnormal_orbit_morphology	0.99968847
61	MP0003937_abnormal_limbs/digits/tail_de	0.98840063
62	MP0004270_analgesia	0.98698635
63	MP0000013_abnormal_adipose_tissue	0.98465711
64	MP0005365_abnormal_bile_salt	0.96576676
65	MP0001502_abnormal_circadian_rhythm	0.92958679
66	MP0004484_altered_response_of	0.91010087
67	MP0003786_premature_aging	0.89726898
68	MP0002078_abnormal_glucose_homeostasis	0.87448456
69	MP0001984_abnormal_olfaction	0.86017416
70	MP0005379_endocrine/exocrine_gland_phen	0.85459516
71	MP0008995_early_reproductive_senescence	0.84965016
72	MP0010329_abnormal_lipoprotein_level	0.84901968
73	MP0008438_abnormal_cutaneous_collagen	0.84445163
74	MP0001501_abnormal_sleep_pattern	0.84410096
75	MP0002272_abnormal_nervous_system	0.84223039
76	MP0001485_abnormal_pinna_reflex	0.82859717
77	MP0003119_abnormal_digestive_system	0.81539561
78	MP0004742_abnormal_vestibular_system	0.80602534
79	MP0000639_abnormal_adrenal_gland	0.80447110
80	MP0003567_abnormal_fetal_cardiomyocyte	0.80279030
81	MP0010386_abnormal_urinary_bladder	0.79765556
82	MP0002928_abnormal_bile_duct	0.78676598
83	MP0000647_abnormal_sebaceous_gland	0.78275938
84	MP0005330_cardiomyopathy	0.76876122
85	MP0002557_abnormal_social/conspecific_i	0.74705349
86	MP0005448_abnormal_energy_balance	0.72824541
87	MP0003953_abnormal_hormone_level	0.71282024
88	MP0002090_abnormal_vision	0.71178087
89	MP0001270_distended_abdomen	0.70922258
90	MP0001286_abnormal_eye_development	0.68966559
91	MP0001188_hyperpigmentation	0.65136234
92	MP0005187_abnormal_penis_morphology	0.63911174
93	MP0000631_abnormal_neuroendocrine_gland	0.63678979
94	MP0004145_abnormal_muscle_electrophysio	0.63295268
95	MP0005391_vision/eye_phenotype	0.61068713
96	MP0004381_abnormal_hair_follicle	0.61000946
97	MP0008872_abnormal_physiological_respon	0.60146535
98	MP0005408_hypopigmentation	0.59510892
99	MP0000749_muscle_degeneration	0.59313741
100	MP0002282_abnormal_trachea_morphology	0.59011527

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic islet-cell hyperplasia (HP:0004510)	7.21615287
2	Hyperinsulinemic hypoglycemia (HP:0000825)	6.47030128
3	Pigmentary retinal degeneration (HP:0001146)	6.35253404
4	Large for gestational age (HP:0001520)	6.21176112
5	Ketoacidosis (HP:0001993)	5.55605387
6	Hypoplasia of the uterus (HP:0000013)	5.29236402
7	Hyperglycemia (HP:0003074)	4.79111749
8	Abnormality of the pancreatic islet cells (HP:0006476)	4.75615018
9	Abnormality of endocrine pancreas physiology (HP:0012093)	4.75615018
10	Aplasia/hypoplasia of the uterus (HP:0008684)	4.65216931
11	Insulin-resistant diabetes mellitus (HP:0000831)	4.50472436
12	Prominent metopic ridge (HP:0005487)	3.97734727
13	Intestinal atresia (HP:0011100)	3.97598123
14	Abnormality of the metopic suture (HP:0005556)	3.87918407
15	Choroideremia (HP:0001139)	3.60407526
16	Hypoplastic ischia (HP:0003175)	3.55121989
17	Metaphyseal dysplasia (HP:0100255)	3.53558611
18	Ketosis (HP:0001946)	3.37057535
19	Double outlet right ventricle (HP:0001719)	3.22446497
20	Congenital malformation of the right heart (HP:0011723)	3.22446497
21	Abnormal pancreas size (HP:0012094)	3.16122182
22	Abnormality of midbrain morphology (HP:0002418)	3.15758609
23	Molar tooth sign on MRI (HP:0002419)	3.15758609
24	Abnormality of lateral ventricle (HP:0030047)	3.14992045
25	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	3.12643651
26	Absent frontal sinuses (HP:0002688)	3.10943727
27	Late onset (HP:0003584)	3.10563172
28	Disproportionate short-trunk short stature (HP:0003521)	3.08538054
29	Abnormality of the ischium (HP:0003174)	2.97251654
30	Hypoplastic pelvis (HP:0008839)	2.89547925
31	Abnormality of the frontal sinuses (HP:0002687)	2.87168034
32	Irregular vertebral endplates (HP:0003301)	2.86060919
33	Hypoglycemic coma (HP:0001325)	2.85764702
34	Hypoglycemic seizures (HP:0002173)	2.59425288
35	Hypothermia (HP:0002045)	2.58845446
36	Abnormality of the vitreous humor (HP:0004327)	2.45456486
37	Glucose intolerance (HP:0000833)	2.44221906
38	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	2.39348286
39	Aplasia of the musculature (HP:0100854)	2.38184504
40	Methylmalonic acidemia (HP:0002912)	2.34095298
41	Hypoplastic left heart (HP:0004383)	2.33242741
42	Hypsarrhythmia (HP:0002521)	2.30482105
43	Oligodactyly (hands) (HP:0001180)	2.30124893
44	Chronic bronchitis (HP:0004469)	2.29913337
45	Adrenal hypoplasia (HP:0000835)	2.27497765
46	Insulin resistance (HP:0000855)	2.27280113
47	Spondylolisthesis (HP:0003302)	2.25645298
48	Anteriorly placed anus (HP:0001545)	2.25267578
49	Hypoplasia of the fovea (HP:0007750)	2.25258871
50	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.25258871
51	Radial bowing (HP:0002986)	2.22948406
52	EEG with generalized epileptiform discharges (HP:0011198)	2.21133065
53	Vacuolated lymphocytes (HP:0001922)	2.18670517
54	Albinism (HP:0001022)	2.15402350
55	Thyroiditis (HP:0100646)	2.11877035
56	Epileptiform EEG discharges (HP:0011182)	2.11049311
57	Abnormality of the fovea (HP:0000493)	2.09521164
58	Metabolic alkalosis (HP:0200114)	2.08290890
59	Exercise-induced muscle cramps (HP:0003710)	2.05375179
60	Fibular hypoplasia (HP:0003038)	2.01352769
61	Irregular epiphyses (HP:0010582)	1.97257890
62	Neuroendocrine neoplasm (HP:0100634)	1.93154298
63	Abnormality of the vertebral endplates (HP:0005106)	1.93023775
64	Abnormality of the renal cortex (HP:0011035)	1.92146624
65	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.91920417
66	Palpitations (HP:0001962)	1.91098701
67	Pancreatic cysts (HP:0001737)	1.90887192
68	Short chin (HP:0000331)	1.87990512
69	Sparse lateral eyebrow (HP:0005338)	1.79952823
70	Hyperventilation (HP:0002883)	1.79050503
71	Hypoplastic heart (HP:0001961)	1.75340707
72	Renal hypoplasia (HP:0000089)	1.74284569
73	Ulnar claw (HP:0001178)	1.69589266
74	Abnormality of vitamin B metabolism (HP:0004340)	1.69425258
75	Methylmalonic aciduria (HP:0012120)	1.64935073
76	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.64190005
77	Protuberant abdomen (HP:0001538)	1.64104833
78	Medial flaring of the eyebrow (HP:0010747)	1.63657109
79	Vitreoretinal degeneration (HP:0000655)	1.62965002
80	Gastrointestinal atresia (HP:0002589)	1.61647191
81	Symptomatic seizures (HP:0011145)	1.60740395
82	Patent foramen ovale (HP:0001655)	1.60128841
83	Pancreatic fibrosis (HP:0100732)	1.59769656
84	True hermaphroditism (HP:0010459)	1.59456734
85	Thickened calvaria (HP:0002684)	1.58693971
86	Congenital stationary night blindness (HP:0007642)	1.58550077
87	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.58123939
88	Increased circulating renin level (HP:0000848)	1.57889342
89	Short tibia (HP:0005736)	1.57348316
90	Abnormality of abdominal situs (HP:0011620)	1.57329586
91	Abdominal situs inversus (HP:0003363)	1.57329586
92	Abnormality of chloride homeostasis (HP:0011422)	1.56527362
93	Abnormal glucose tolerance (HP:0001952)	1.55952006
94	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.55928205
95	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	1.54655040
96	Abnormality of proline metabolism (HP:0010907)	1.53832389
97	Hydroxyprolinuria (HP:0003080)	1.53832389
98	Furrowed tongue (HP:0000221)	1.53509186
99	Glycosuria (HP:0003076)	1.53361130
100	Abnormality of urine glucose concentration (HP:0011016)	1.53361130

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PRKD3	6.80669741
2	PKN2	4.81123069
3	FRK	4.50621597
4	MST4	3.86448245
5	FLT3	3.38116116
6	TRPM7	2.79691911
7	MAP4K2	2.64828886
8	EPHA3	2.45378445
9	TAF1	2.39948464
10	FGFR2	1.98162897
11	PINK1	1.83186436
12	MAP3K4	1.78887268
13	NUAK1	1.72760224
14	TNIK	1.68556034
15	MAP3K7	1.66303555
16	ADRBK2	1.58399734
17	CASK	1.53056746
18	MAPKAPK3	1.50381893
19	TYK2	1.39849874
20	AKT3	1.37230063
21	DYRK3	1.35550991
22	OBSCN	1.32350845
23	WNK3	1.31118094
24	DAPK2	1.17575966
25	MAP2K7	1.17236530
26	BMPR1B	1.16348080
27	ERBB4	1.05239098
28	GRK1	1.04402560
29	SIK3	1.02912575
30	DMPK	0.99977770
31	PRKCE	0.98980514
32	SGK2	0.98930061
33	PTK2B	0.96234183
34	FGFR3	0.92530288
35	BCR	0.92479785
36	CAMK2D	0.90383475
37	PHKG2	0.87532761
38	PHKG1	0.87532761
39	LIMK1	0.87167105
40	IRAK4	0.85958727
41	MAPK13	0.85020940
42	EPHB1	0.82564427
43	STK10	0.81836156
44	RPS6KB2	0.78366367
45	TNK2	0.78328576
46	JAK1	0.72765884
47	GRK7	0.71883553
48	TRIM28	0.71662441
49	FER	0.67714491
50	CSNK1G2	0.67433631
51	STK16	0.67353905
52	PLK2	0.66648040
53	PAK3	0.66052577
54	CSNK1G1	0.65843475
55	ADRBK1	0.63995856
56	SGK3	0.62638811
57	RPS6KA4	0.62456969
58	FGFR1	0.61945726
59	PRKAA2	0.61939449
60	ERBB3	0.59677059
61	RET	0.59548940
62	NLK	0.56545100
63	EPHA2	0.56140967
64	MAP3K12	0.55937958
65	STK38L	0.54773486
66	MAP2K6	0.54217937
67	CSNK1A1L	0.54181782
68	IKBKE	0.52300132
69	EEF2K	0.50562246
70	PNCK	0.50101088
71	BCKDK	0.50076041
72	ACVR1B	0.49553145
73	ROCK1	0.43622895
74	MAP3K6	0.42425178
75	TLK1	0.41203641
76	INSRR	0.40716443
77	CSNK1G3	0.39124024
78	SGK223	0.38992090
79	SGK494	0.38992090
80	PRKD2	0.38768244
81	HIPK2	0.36390780
82	ZAK	0.36049719
83	PDK1	0.34868023
84	CDK8	0.34569790
85	MAP2K4	0.33680342
86	PRKCI	0.33525396
87	MAPKAPK5	0.32979231
88	OXSR1	0.32194837
89	SIK1	0.31671833
90	PRKCG	0.30596249
91	IRAK1	0.29905415
92	PRKACA	0.26508132
93	LATS1	0.26055287
94	PRKAA1	0.25987280
95	MYLK	0.25980824
96	GRK5	0.24992878
97	PRKG1	0.23019894
98	PRKD1	0.22233848
99	ILK	0.21916299
100	MARK3	0.20126176

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	4.57389269
2	Circadian rhythm_Homo sapiens_hsa04710	3.92429042
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.30582873
4	Insulin secretion_Homo sapiens_hsa04911	2.91981851
5	Collecting duct acid secretion_Homo sapiens_hsa04966	2.76245142
6	Butanoate metabolism_Homo sapiens_hsa00650	2.33396589
7	Propanoate metabolism_Homo sapiens_hsa00640	2.13130467
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.12838532
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.06541881
10	Phototransduction_Homo sapiens_hsa04744	2.05643103
11	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.04756356
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.04739925
13	Protein export_Homo sapiens_hsa03060	2.00822269
14	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.89387353
15	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.69652039
16	Type II diabetes mellitus_Homo sapiens_hsa04930	1.63953506
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.63673145
18	Regulation of autophagy_Homo sapiens_hsa04140	1.62210926
19	Peroxisome_Homo sapiens_hsa04146	1.47440562
20	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.46151467
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.35285799
22	Renin secretion_Homo sapiens_hsa04924	1.33742955
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.27918717
24	Glucagon signaling pathway_Homo sapiens_hsa04922	1.24671771
25	Sulfur metabolism_Homo sapiens_hsa00920	1.19509441
26	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.18368874
27	Circadian entrainment_Homo sapiens_hsa04713	1.14452585
28	Fatty acid elongation_Homo sapiens_hsa00062	1.00316463
29	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.98791396
30	Oxidative phosphorylation_Homo sapiens_hsa00190	0.97673496
31	beta-Alanine metabolism_Homo sapiens_hsa00410	0.97120240
32	Type I diabetes mellitus_Homo sapiens_hsa04940	0.95749056
33	Nitrogen metabolism_Homo sapiens_hsa00910	0.95654535
34	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.93246073
35	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.90590040
36	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.89005476
37	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.88741567
38	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.88560632
39	Taste transduction_Homo sapiens_hsa04742	0.88112840
40	Tryptophan metabolism_Homo sapiens_hsa00380	0.88081738
41	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.86942289
42	Arginine and proline metabolism_Homo sapiens_hsa00330	0.86272423
43	Fatty acid metabolism_Homo sapiens_hsa01212	0.86190255
44	Amphetamine addiction_Homo sapiens_hsa05031	0.84614969
45	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.82334726
46	Mineral absorption_Homo sapiens_hsa04978	0.82006331
47	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.80717004
48	ABC transporters_Homo sapiens_hsa02010	0.80249205
49	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.77078553
50	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.77066395
51	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.76423430
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.75502750
53	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.72989292
54	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.72002013
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.70815671
56	Fatty acid degradation_Homo sapiens_hsa00071	0.69391804
57	Selenocompound metabolism_Homo sapiens_hsa00450	0.69248127
58	Salivary secretion_Homo sapiens_hsa04970	0.68323911
59	Protein digestion and absorption_Homo sapiens_hsa04974	0.67757466
60	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.64246779
61	Long-term depression_Homo sapiens_hsa04730	0.63523931
62	RNA degradation_Homo sapiens_hsa03018	0.61807387
63	RNA polymerase_Homo sapiens_hsa03020	0.61540368
64	Dopaminergic synapse_Homo sapiens_hsa04728	0.61422676
65	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.60726618
66	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.60440673
67	Serotonergic synapse_Homo sapiens_hsa04726	0.59497899
68	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.58096818
69	Folate biosynthesis_Homo sapiens_hsa00790	0.57915088
70	Fat digestion and absorption_Homo sapiens_hsa04975	0.57493311
71	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.57433061
72	Cardiac muscle contraction_Homo sapiens_hsa04260	0.57236513
73	cAMP signaling pathway_Homo sapiens_hsa04024	0.56794706
74	Caffeine metabolism_Homo sapiens_hsa00232	0.56473218
75	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.54334751
76	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.54176705
77	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.54162815
78	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.52043681
79	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.51827124
80	Insulin resistance_Homo sapiens_hsa04931	0.49085156
81	Vibrio cholerae infection_Homo sapiens_hsa05110	0.48530048
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.47009354
83	Non-homologous end-joining_Homo sapiens_hsa03450	0.46725770
84	Glutathione metabolism_Homo sapiens_hsa00480	0.46077669
85	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.45919997
86	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.45300162
87	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.45184494
88	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.44736546
89	Complement and coagulation cascades_Homo sapiens_hsa04610	0.44083498
90	Parkinsons disease_Homo sapiens_hsa05012	0.42934083
91	Metabolic pathways_Homo sapiens_hsa01100	0.42523991
92	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.42326610
93	Legionellosis_Homo sapiens_hsa05134	0.40855241
94	Bile secretion_Homo sapiens_hsa04976	0.40529402
95	Other glycan degradation_Homo sapiens_hsa00511	0.39169903
96	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.38422816
97	One carbon pool by folate_Homo sapiens_hsa00670	0.37962396
98	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.37366456
99	Sphingolipid metabolism_Homo sapiens_hsa00600	0.37326070
100	Retinol metabolism_Homo sapiens_hsa00830	0.36640882

KCTD9P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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