KDELC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein product localized to the lumen of the endoplasmic reticulum. As a member of the endoplasmic reticulum protein family the encoded protein contains a Lys-Asp-Glu-Leu or KDEL motif located at the extreme C-terminus which prevents all endoplasmic reticulum resident proteins from being secreted. Proteins carrying this motif are bound by a receptor in the Golgi apparatus so that the receptor-ligand complex returns to the endoplasmic reticulum. A processed non-transcribed pseudogene located in an intron of a sodium transporter gene on chromosome 5 has been defined for this gene. This gene has multiple transcript variants which are predicted to encode distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.05539069
2DNA unwinding involved in DNA replication (GO:0006268)4.63574698
3DNA strand elongation involved in DNA replication (GO:0006271)4.37867310
4L-serine metabolic process (GO:0006563)4.33919066
5DNA strand elongation (GO:0022616)4.27569970
6DNA replication initiation (GO:0006270)4.20353709
7IMP biosynthetic process (GO:0006188)4.17235252
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.16718108
9regulation of plasminogen activation (GO:0010755)4.11229763
10telomere maintenance via semi-conservative replication (GO:0032201)4.08825391
11CENP-A containing nucleosome assembly (GO:0034080)4.04923076
12homocysteine metabolic process (GO:0050667)3.92523690
13chromatin remodeling at centromere (GO:0031055)3.87560144
14viral transcription (GO:0019083)3.86161326
15IMP metabolic process (GO:0046040)3.85940294
16translational termination (GO:0006415)3.79343673
17nucleobase biosynthetic process (GO:0046112)3.70042064
18maturation of SSU-rRNA (GO:0030490)3.59337018
19telomere maintenance via recombination (GO:0000722)3.57605519
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.57541847
21cotranslational protein targeting to membrane (GO:0006613)3.49434641
22protein localization to chromosome, centromeric region (GO:0071459)3.48879441
23DNA replication-independent nucleosome organization (GO:0034724)3.48099631
24DNA replication-independent nucleosome assembly (GO:0006336)3.48099631
25protein targeting to ER (GO:0045047)3.46260688
26translational elongation (GO:0006414)3.45963861
27mitotic recombination (GO:0006312)3.44199109
28serine family amino acid biosynthetic process (GO:0009070)3.44072490
29ribosomal small subunit biogenesis (GO:0042274)3.43356737
30formation of translation preinitiation complex (GO:0001731)3.39210685
31kinetochore organization (GO:0051383)3.33386225
32deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.33135429
33DNA replication-dependent nucleosome assembly (GO:0006335)3.29176459
34DNA replication-dependent nucleosome organization (GO:0034723)3.29176459
35establishment of protein localization to endoplasmic reticulum (GO:0072599)3.27390600
36protein localization to endoplasmic reticulum (GO:0070972)3.22547646
37telomere maintenance via telomere lengthening (GO:0010833)3.18353312
38mitotic nuclear envelope disassembly (GO:0007077)3.18311974
39folic acid-containing compound biosynthetic process (GO:0009396)3.17221459
40nucleotide-excision repair, DNA gap filling (GO:0006297)3.14786283
41protein localization to kinetochore (GO:0034501)3.14432181
42purine nucleobase biosynthetic process (GO:0009113)3.12114983
43nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.10576255
44translational initiation (GO:0006413)3.06794937
45viral life cycle (GO:0019058)3.01203901
46DNA replication checkpoint (GO:0000076)2.99710483
47histone exchange (GO:0043486)2.98191931
48establishment of integrated proviral latency (GO:0075713)2.97416067
49nuclear pore complex assembly (GO:0051292)2.97265437
50regulation of spindle organization (GO:0090224)2.96833630
51RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.96227636
52tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.96227636
53proteasome assembly (GO:0043248)2.95771280
54DNA ligation (GO:0006266)2.95018866
55spliceosomal snRNP assembly (GO:0000387)2.94640606
56ribosomal large subunit biogenesis (GO:0042273)2.91621325
57cellular protein complex disassembly (GO:0043624)2.88718051
58nuclear envelope disassembly (GO:0051081)2.88105824
59membrane disassembly (GO:0030397)2.88105824
60DNA damage response, detection of DNA damage (GO:0042769)2.85177804
61kinetochore assembly (GO:0051382)2.78813830
62translesion synthesis (GO:0019985)2.78411662
63mitochondrial RNA metabolic process (GO:0000959)2.78255728
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.77770701
65negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.76709601
66ribonucleoprotein complex biogenesis (GO:0022613)2.76211533
67DNA deamination (GO:0045006)2.75873801
68regulation of mitochondrial translation (GO:0070129)2.74550653
69heterochromatin organization (GO:0070828)2.73938264
70ribosome biogenesis (GO:0042254)2.73868609
71negative regulation of chondrocyte differentiation (GO:0032331)2.71610244
72mismatch repair (GO:0006298)2.71012605
73mitotic chromosome condensation (GO:0007076)2.70376749
744-hydroxyproline metabolic process (GO:0019471)2.68270156
75negative regulation of RNA splicing (GO:0033119)2.67783794
76mitotic sister chromatid segregation (GO:0000070)2.67376738
77ATP-dependent chromatin remodeling (GO:0043044)2.66646626
78postreplication repair (GO:0006301)2.66229930
79regulation of mitotic spindle organization (GO:0060236)2.65952006
80nuclear-transcribed mRNA catabolic process (GO:0000956)2.65644816
81translation (GO:0006412)2.64807133
82sister chromatid segregation (GO:0000819)2.63757841
83protein complex disassembly (GO:0043241)2.63512868
84paraxial mesoderm development (GO:0048339)2.62757082
85ventricular cardiac muscle cell development (GO:0055015)2.62049344
86maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.61948584
87viral mRNA export from host cell nucleus (GO:0046784)2.61208400
88meiotic chromosome segregation (GO:0045132)2.60969925
89mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.59055562
90tetrahydrofolate metabolic process (GO:0046653)2.58819741
91rRNA processing (GO:0006364)2.58427136
92negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.57821186
93cysteine metabolic process (GO:0006534)2.57779278
94RNA splicing, via transesterification reactions (GO:0000375)2.57192353
95pseudouridine synthesis (GO:0001522)2.56893123
96RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.56309442
97mRNA splicing, via spliceosome (GO:0000398)2.56309442
98DNA duplex unwinding (GO:0032508)2.56120894
99DNA topological change (GO:0006265)2.55654847
100pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.55422982
101G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.54526743
102spliceosomal complex assembly (GO:0000245)2.53905040
103G1/S transition of mitotic cell cycle (GO:0000082)2.53861867
104cell cycle G1/S phase transition (GO:0044843)2.53861867
105mRNA catabolic process (GO:0006402)2.53742384
106regulation of translational fidelity (GO:0006450)2.53313140
107DNA geometric change (GO:0032392)2.53051957
108spindle assembly checkpoint (GO:0071173)2.52833413
109epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.52777535
110pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.52234279
111chromosome condensation (GO:0030261)2.52187192
112protein complex localization (GO:0031503)2.52173207
113pteridine-containing compound biosynthetic process (GO:0042559)2.52166036
114mitotic metaphase plate congression (GO:0007080)2.52127223
115chromatin assembly or disassembly (GO:0006333)2.51188728
1163-UTR-mediated mRNA stabilization (GO:0070935)2.51099144
117peptidyl-histidine modification (GO:0018202)2.50818306
118mitotic spindle assembly checkpoint (GO:0007094)2.50431886
119negative regulation of mitotic sister chromatid separation (GO:2000816)2.49840803
120negative regulation of mitotic sister chromatid segregation (GO:0033048)2.49840803
121negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.49840803
122negative regulation of sister chromatid segregation (GO:0033046)2.49840803
123telomere organization (GO:0032200)2.49496539
124cellular protein complex localization (GO:0034629)2.49351722
125peptidyl-arginine omega-N-methylation (GO:0035247)2.49189215
126establishment of viral latency (GO:0019043)2.48430853
127telomere maintenance (GO:0000723)2.48007530
128metaphase plate congression (GO:0051310)2.47855887
129rRNA modification (GO:0000154)2.47638593
130anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.47024690
131nuclear pore organization (GO:0006999)2.46712299
132purine-containing compound salvage (GO:0043101)2.46698917
133outer ear morphogenesis (GO:0042473)2.46495658
134regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.46244520
135negative regulation of chromosome segregation (GO:0051985)2.46047700
136protein retention in ER lumen (GO:0006621)2.43196162
137ribosome assembly (GO:0042255)2.42688723
138chaperone-mediated protein transport (GO:0072321)2.40982030
139notochord development (GO:0030903)2.40031549
140spindle checkpoint (GO:0031577)2.39235952
141sulfur amino acid catabolic process (GO:0000098)2.35711254
142base-excision repair (GO:0006284)2.35597339
143folic acid-containing compound metabolic process (GO:0006760)2.34647584
144regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.34382201
145rRNA methylation (GO:0031167)2.33301337
146Golgi transport vesicle coating (GO:0048200)2.32524131
147COPI coating of Golgi vesicle (GO:0048205)2.32524131
148histone arginine methylation (GO:0034969)2.30407809
149non-recombinational repair (GO:0000726)2.28913357
150double-strand break repair via nonhomologous end joining (GO:0006303)2.28913357
151mitotic spindle checkpoint (GO:0071174)2.28867538
152glycine metabolic process (GO:0006544)2.28001481
153pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.24982966
154bone trabecula formation (GO:0060346)2.24938108
155serine family amino acid catabolic process (GO:0009071)2.24659370
156peptidyl-proline hydroxylation (GO:0019511)2.23940534
157response to BMP (GO:0071772)2.23336213
158cellular response to BMP stimulus (GO:0071773)2.23336213

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.07495469
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.45343530
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.71923512
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.54773944
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.32253482
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.29786201
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.27610970
8RBPJ_22232070_ChIP-Seq_NCS_Mouse3.14939922
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.98311437
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.88550126
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.84964261
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82797019
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.77730330
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.69371561
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.65768839
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.49540317
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.47133245
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.43996344
19XRN2_22483619_ChIP-Seq_HELA_Human2.42474707
20AR_21909140_ChIP-Seq_LNCAP_Human2.40208429
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.36743223
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.27318095
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.22378062
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.22158688
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.17509541
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.07380673
27E2F1_21310950_ChIP-Seq_MCF-7_Human2.05450165
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.05283095
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.03545764
30ELK1_19687146_ChIP-ChIP_HELA_Human1.98110644
31VDR_23849224_ChIP-Seq_CD4+_Human1.94225552
32DCP1A_22483619_ChIP-Seq_HELA_Human1.91860569
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88833975
34* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87451614
35FOXP3_21729870_ChIP-Seq_TREG_Human1.85840809
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.84055896
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.83521398
38TTF2_22483619_ChIP-Seq_HELA_Human1.81250424
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.74788373
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74549707
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.71229611
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.71009162
43NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.67411426
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67129000
45GABP_19822575_ChIP-Seq_HepG2_Human1.64030345
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63254086
47* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.62768772
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.62741384
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62323119
50ESR1_15608294_ChIP-ChIP_MCF-7_Human1.61827258
51ZNF263_19887448_ChIP-Seq_K562_Human1.58821329
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.56706707
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.56336903
54* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.56148455
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52479302
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.51943980
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.45692900
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44742816
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35537729
60KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.34576982
61* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34309444
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31899239
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30827372
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29396961
65* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28978287
66TRIM28_21343339_ChIP-Seq_HEK293_Human1.26116542
67CIITA_25753668_ChIP-Seq_RAJI_Human1.25834050
68MYC_22102868_ChIP-Seq_BL_Human1.25121084
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.22805341
70TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.21304991
71SCL_19346495_ChIP-Seq_HPC-7_Human1.19342225
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.18943641
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.17063275
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.16335462
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15519313
76* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13439908
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.12550213
78CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12503718
79WT1_19549856_ChIP-ChIP_CCG9911_Human1.09322007
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09132581
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08495753
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08036953
83ELK1_22589737_ChIP-Seq_MCF10A_Human1.07799788
84VDR_21846776_ChIP-Seq_THP-1_Human1.06712699
85KDM5A_27292631_Chip-Seq_BREAST_Human1.06262710
86* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05895105
87TFEB_21752829_ChIP-Seq_HELA_Human1.05466442
88* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05285418
89PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05039719
90HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04749854
91CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03745874
92TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03536305
93NANOG_16153702_ChIP-ChIP_HESCs_Human1.00044824
94SOX2_18692474_ChIP-Seq_MEFs_Mouse0.99656261
95SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99191238
96CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98888420
97NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98224769
98HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97479545
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97377894
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97256547
101FUS_26573619_Chip-Seq_HEK293_Human0.97071555
102SPI1_23547873_ChIP-Seq_NB4_Human0.95728207
103MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95726504
104YY1_21170310_ChIP-Seq_MESCs_Mouse0.94062578
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92630533
106* SOX17_20123909_ChIP-Seq_XEN_Mouse0.92507104
107KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92065577
108TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91392227
109MYC_18940864_ChIP-ChIP_HL60_Human0.91188475
110PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89850228
111CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87902364
112NANOG_21062744_ChIP-ChIP_HESCs_Human0.87901431
113TCF3_18692474_ChIP-Seq_MEFs_Mouse0.83268082
114SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82212485
115STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81472367
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.81000465
117DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80589095
118SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79900600
119CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.79621003
120GATA4_21415370_ChIP-Seq_HL-1_Mouse0.77578133
121ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.77290436
122TP63_17297297_ChIP-ChIP_HaCaT_Human0.77076699
123* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.76931356
124CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.76810662
125EWS_26573619_Chip-Seq_HEK293_Human0.76615209
126TBX5_21415370_ChIP-Seq_HL-1_Mouse0.76553943
127SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.75866959
128NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.74593374

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.19543051
2MP0006054_spinal_hemorrhage2.96069605
3MP0008438_abnormal_cutaneous_collagen2.87618676
4MP0010030_abnormal_orbit_morphology2.66217325
5MP0003693_abnormal_embryo_hatching2.63399242
6MP0010094_abnormal_chromosome_stability2.57100053
7MP0003077_abnormal_cell_cycle2.54560911
8MP0004957_abnormal_blastocyst_morpholog2.51105489
9MP0008007_abnormal_cellular_replicative2.49053854
10MP0003123_paternal_imprinting2.48056460
11MP0008057_abnormal_DNA_replication2.40569715
12MP0005503_abnormal_tendon_morphology2.33328275
13MP0008058_abnormal_DNA_repair2.32503588
14MP0003111_abnormal_nucleus_morphology2.18585391
15MP0008932_abnormal_embryonic_tissue2.10535419
16MP0009384_cardiac_valve_regurgitation1.96444357
17MP0004808_abnormal_hematopoietic_stem1.91450348
18MP0002697_abnormal_eye_size1.88278611
19MP0000537_abnormal_urethra_morphology1.86702798
20MP0003942_abnormal_urinary_system1.74344729
21MP0006292_abnormal_olfactory_placode1.73653850
22MP0009053_abnormal_anal_canal1.70367043
23MP0002938_white_spotting1.62978388
24MP0001293_anophthalmia1.58953355
25MP0000350_abnormal_cell_proliferation1.58774536
26MP0000049_abnormal_middle_ear1.57317707
27MP0004272_abnormal_basement_membrane1.55410020
28MP0003279_aneurysm1.55031219
29MP0001661_extended_life_span1.54911186
30MP0003890_abnormal_embryonic-extraembry1.53495187
31MP0002282_abnormal_trachea_morphology1.51407881
32MP0003567_abnormal_fetal_cardiomyocyte1.50495354
33MP0009379_abnormal_foot_pigmentation1.49171092
34MP0005023_abnormal_wound_healing1.45217605
35MP0003122_maternal_imprinting1.44459321
36MP0003121_genomic_imprinting1.43332416
37MP0005360_urolithiasis1.43303748
38MP0010368_abnormal_lymphatic_system1.42554791
39MP0001286_abnormal_eye_development1.41806137
40MP0002233_abnormal_nose_morphology1.39537090
41MP0009250_abnormal_appendicular_skeleto1.38734272
42MP0003385_abnormal_body_wall1.37827162
43MP0004197_abnormal_fetal_growth/weight/1.35962843
44MP0009697_abnormal_copulation1.33620745
45MP0004084_abnormal_cardiac_muscle1.32006894
46MP0001730_embryonic_growth_arrest1.31881027
47MP0001697_abnormal_embryo_size1.31851717
48MP0004133_heterotaxia1.31517000
49MP0005171_absent_coat_pigmentation1.31229222
50MP0003937_abnormal_limbs/digits/tail_de1.28733491
51MP0000762_abnormal_tongue_morphology1.26780977
52MP0003186_abnormal_redox_activity1.26256627
53MP0005508_abnormal_skeleton_morphology1.24613506
54MP0000490_abnormal_crypts_of1.24460573
55MP0003718_maternal_effect1.24172252
56MP0001915_intracranial_hemorrhage1.23406664
57MP0002932_abnormal_joint_morphology1.23231132
58MP0004147_increased_porphyrin_level1.21970377
59MP0002111_abnormal_tail_morphology1.20464850
60MP0005275_abnormal_skin_tensile1.20149697
61MP0003315_abnormal_perineum_morphology1.18738241
62MP0001299_abnormal_eye_distance/1.17914681
63MP0003984_embryonic_growth_retardation1.17560267
64MP0003943_abnormal_hepatobiliary_system1.16683085
65MP0001672_abnormal_embryogenesis/_devel1.16422865
66MP0005380_embryogenesis_phenotype1.16422865
67MP0002234_abnormal_pharynx_morphology1.16184170
68MP0003786_premature_aging1.15179571
69MP0002085_abnormal_embryonic_tissue1.14731727
70MP0002088_abnormal_embryonic_growth/wei1.14682483
71MP0009672_abnormal_birth_weight1.14268294
72MP0003828_pulmonary_edema1.12476703
73MP0002084_abnormal_developmental_patter1.10634386
74MP0000428_abnormal_craniofacial_morphol1.10403816
75MP0003119_abnormal_digestive_system1.10389456
76MP0002249_abnormal_larynx_morphology1.08913076
77MP0004858_abnormal_nervous_system1.08066972
78MP0005257_abnormal_intraocular_pressure1.07422192
79MP0005197_abnormal_uvea_morphology1.06505978
80MP0005623_abnormal_meninges_morphology1.04879304
81MP0002080_prenatal_lethality1.04195072
82MP0003566_abnormal_cell_adhesion1.00792646
83MP0010352_gastrointestinal_tract_polyps1.00552745
84MP0000534_abnormal_ureter_morphology1.00204813
85MP0000163_abnormal_cartilage_morphology1.00021169
86MP0002086_abnormal_extraembryonic_tissu0.98791826
87MP0003115_abnormal_respiratory_system0.96377119
88MP0008789_abnormal_olfactory_epithelium0.95859294
89MP0010307_abnormal_tumor_latency0.94283943
90MP0002089_abnormal_postnatal_growth/wei0.93074719
91MP0000749_muscle_degeneration0.92183839
92MP0000013_abnormal_adipose_tissue0.92092205
93MP0002092_abnormal_eye_morphology0.90952906
94MP0004134_abnormal_chest_morphology0.90827252
95MP0002160_abnormal_reproductive_system0.90310529
96MP0003705_abnormal_hypodermis_morpholog0.90147288
97MP0000313_abnormal_cell_death0.89416966
98MP0002109_abnormal_limb_morphology0.87437813
99MP0000733_abnormal_muscle_development0.86708552
100MP0001879_abnormal_lymphatic_vessel0.84767223
101MP0002113_abnormal_skeleton_development0.83804022
102MP0003935_abnormal_craniofacial_develop0.83402545
103MP0001340_abnormal_eyelid_morphology0.82923962
104MP0003755_abnormal_palate_morphology0.81724485
105MP0009703_decreased_birth_body0.81360279
106MP0003861_abnormal_nervous_system0.80151506
107MP0005220_abnormal_exocrine_pancreas0.79818786
108MP0005187_abnormal_penis_morphology0.78952684
109MP0000465_gastrointestinal_hemorrhage0.78911372
110MP0002115_abnormal_skeleton_extremities0.78153976
111MP0005367_renal/urinary_system_phenotyp0.77927102
112MP0000516_abnormal_urinary_system0.77927102
113MP0001545_abnormal_hematopoietic_system0.77885742
114MP0005397_hematopoietic_system_phenotyp0.77885742
115MP0002877_abnormal_melanocyte_morpholog0.76120469
116MP0005646_abnormal_pituitary_gland0.75724103
117MP0003941_abnormal_skin_development0.75242651
118MP0000767_abnormal_smooth_muscle0.75196735
119MP0000432_abnormal_head_morphology0.75067375
120MP0008995_early_reproductive_senescence0.74891473
121MP0002019_abnormal_tumor_incidence0.74372844
122MP0002128_abnormal_blood_circulation0.74311988
123MP0001243_abnormal_dermal_layer0.74179288
124MP0003136_yellow_coat_color0.74039144
125MP0003806_abnormal_nucleotide_metabolis0.73865195
126MP0002925_abnormal_cardiovascular_devel0.73459036
127MP0002060_abnormal_skin_morphology0.73195434
128MP0004233_abnormal_muscle_weight0.73180898
129MP0002177_abnormal_outer_ear0.72727539
130MP0002114_abnormal_axial_skeleton0.72574806
131MP0002116_abnormal_craniofacial_bone0.72281102
132MP0002108_abnormal_muscle_morphology0.71985855
133MP0001614_abnormal_blood_vessel0.71923866
134MP0006072_abnormal_retinal_apoptosis0.71914143
135MP0000566_synostosis0.71264556
136MP0005391_vision/eye_phenotype0.71196320

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.01158122
2Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.68539712
3Abnormality of alanine metabolism (HP:0010916)3.68539712
4Hyperalaninemia (HP:0003348)3.68539712
5Reticulocytopenia (HP:0001896)3.56908041
6Aplastic anemia (HP:0001915)3.48781383
7Colon cancer (HP:0003003)3.19532577
8Degeneration of anterior horn cells (HP:0002398)3.08023991
9Abnormality of the anterior horn cell (HP:0006802)3.08023991
10Epiphyseal dysplasia (HP:0002656)3.04889182
11Abnormality of cells of the erythroid lineage (HP:0012130)2.98814867
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.98072838
13Short 4th metacarpal (HP:0010044)2.98072838
14Abnormal number of erythroid precursors (HP:0012131)2.97982706
15Small epiphyses (HP:0010585)2.85325735
16Premature rupture of membranes (HP:0001788)2.83830109
17Selective tooth agenesis (HP:0001592)2.83670854
18Hyperglycinemia (HP:0002154)2.77857592
19Irregular epiphyses (HP:0010582)2.72296323
20Birth length less than 3rd percentile (HP:0003561)2.68098939
21Mild short stature (HP:0003502)2.64867484
22Biconcave vertebral bodies (HP:0004586)2.53824594
23Ankle contracture (HP:0006466)2.49828735
24Thrombocytosis (HP:0001894)2.44332461
25Abnormality of serum amino acid levels (HP:0003112)2.42547865
26Coronal craniosynostosis (HP:0004440)2.40621189
27Soft skin (HP:0000977)2.36686988
28Increased serum pyruvate (HP:0003542)2.36333209
29Chromsome breakage (HP:0040012)2.36251910
30Carpal bone hypoplasia (HP:0001498)2.34310560
31Mesangial abnormality (HP:0001966)2.29427803
32Medulloblastoma (HP:0002885)2.24432299
33Type I transferrin isoform profile (HP:0003642)2.23390584
34Neonatal short-limb short stature (HP:0008921)2.18772412
3511 pairs of ribs (HP:0000878)2.13921499
36Abnormality of dentin (HP:0010299)2.12573659
37Slender long bone (HP:0003100)2.09910312
38Syringomyelia (HP:0003396)2.07318139
39Spinal cord lesions (HP:0100561)2.07318139
40Aortic aneurysm (HP:0004942)2.07159190
41Abnormality of glycolysis (HP:0004366)2.04080100
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.03669718
43Abnormality of the 4th metacarpal (HP:0010012)2.02855665
44Short middle phalanx of the 5th finger (HP:0004220)2.02736327
45Cervical subluxation (HP:0003308)2.02281040
46Duplication of thumb phalanx (HP:0009942)2.01050674
47Glossoptosis (HP:0000162)1.98426130
48Abnormality of the calcaneus (HP:0008364)1.97719110
49Microvesicular hepatic steatosis (HP:0001414)1.97167790
50Abnormality of methionine metabolism (HP:0010901)1.96955717
51Aplasia/Hypoplasia of the sacrum (HP:0008517)1.96942187
52Abnormal lung lobation (HP:0002101)1.96473527
53Aortic dissection (HP:0002647)1.94306742
54Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.93096733
55Pallor (HP:0000980)1.93079826
56Deviation of the thumb (HP:0009603)1.91829571
57Hypoplasia of the capital femoral epiphysis (HP:0003090)1.90560936
58Partial duplication of the phalanx of hand (HP:0009999)1.90096720
59Abnormality of chromosome stability (HP:0003220)1.89015728
60Delayed cranial suture closure (HP:0000270)1.88689886
61Blue sclerae (HP:0000592)1.87143871
62Bladder diverticulum (HP:0000015)1.86054432
63Stenosis of the external auditory canal (HP:0000402)1.86037031
64Nephroblastoma (Wilms tumor) (HP:0002667)1.85910632
65Abnormality of the acetabulum (HP:0003170)1.85370304
66Short 5th finger (HP:0009237)1.84702882
67Shallow orbits (HP:0000586)1.84023740
68Proximal placement of thumb (HP:0009623)1.83987851
69Abnormal number of incisors (HP:0011064)1.83838067
70Embryonal renal neoplasm (HP:0011794)1.83520972
71Cortical dysplasia (HP:0002539)1.83376071
72Vertebral compression fractures (HP:0002953)1.82452676
73Overlapping toe (HP:0001845)1.82075592
74Atresia of the external auditory canal (HP:0000413)1.81200089
75Hypoplastic left heart (HP:0004383)1.81097494
76Supernumerary spleens (HP:0009799)1.80778431
77Horseshoe kidney (HP:0000085)1.79501992
78Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.79298043
79Aplasia/Hypoplasia of the uvula (HP:0010293)1.78787295
80Meckel diverticulum (HP:0002245)1.78119861
81Oral leukoplakia (HP:0002745)1.77098997
82Wormian bones (HP:0002645)1.76757597
83Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.76585704
84Absent epiphyses (HP:0010577)1.76585704
85Broad metatarsal (HP:0001783)1.76163451
86Abnormality of the ileum (HP:0001549)1.76139290
87Short tibia (HP:0005736)1.75963041
88Reduced antithrombin III activity (HP:0001976)1.75927564
89Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.75705919
90Abnormal protein N-linked glycosylation (HP:0012347)1.75705919
91Abnormal protein glycosylation (HP:0012346)1.75705919
92Abnormal glycosylation (HP:0012345)1.75705919
93Calcaneovalgus deformity (HP:0001848)1.74800147
94Patellar aplasia (HP:0006443)1.74739118
95Patchy hypopigmentation of hair (HP:0011365)1.74706610
96Mesomelia (HP:0003027)1.74053040
97Ectopia lentis (HP:0001083)1.73251961
98Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.72891080
99Delayed closure of the anterior fontanelle (HP:0001476)1.72009364
100Abnormality of the phalanges of the 2nd finger (HP:0009541)1.71895269
101Hypoplasia of the pons (HP:0012110)1.71560137
102Flat capital femoral epiphysis (HP:0003370)1.71177099
103Renal duplication (HP:0000075)1.70629221
104Thin ribs (HP:0000883)1.70365811
105Agnosia (HP:0010524)1.70270228
106Abnormal delivery (HP:0001787)1.70218209
107Spinal muscular atrophy (HP:0007269)1.69987211
108Delayed epiphyseal ossification (HP:0002663)1.69866820
109Abnormality of the pons (HP:0007361)1.69309708
110Abnormalities of placenta or umbilical cord (HP:0001194)1.68969665
111Myelodysplasia (HP:0002863)1.68581767
112Maternal diabetes (HP:0009800)1.68404875
113Neoplasm of the pancreas (HP:0002894)1.67652410
114Broad long bones (HP:0005622)1.66635423
115Abnormality of carpal bone ossification (HP:0006257)1.66439950
116Abnormality of sulfur amino acid metabolism (HP:0004339)1.64736548
117White forelock (HP:0002211)1.64466191
118Abnormality of the fetal cardiovascular system (HP:0010948)1.64390590
119Abnormal umbilical cord blood vessels (HP:0011403)1.64390590
120Single umbilical artery (HP:0001195)1.64390590
121Macrocytic anemia (HP:0001972)1.64318751
122Carpal synostosis (HP:0009702)1.63283753
123Congenital, generalized hypertrichosis (HP:0004540)1.63035514
124Breech presentation (HP:0001623)1.62338147
125Partial duplication of thumb phalanx (HP:0009944)1.61856701
126Platyspondyly (HP:0000926)1.61616381
127Spastic diplegia (HP:0001264)1.61038602
128Mitral valve prolapse (HP:0001634)1.60600037
129Aplasia/Hypoplasia of the patella (HP:0006498)1.60523171
130Premature graying of hair (HP:0002216)1.59991333
131Abnormality of the phalanges of the hallux (HP:0010057)1.59863874
132Bifid tongue (HP:0010297)1.59252175
133Abnormality of the umbilical cord (HP:0010881)1.59130692
134Decreased skull ossification (HP:0004331)1.59065744
135Broad thumb (HP:0011304)1.57652015
136Fragile skin (HP:0001030)1.57544903
137Diastasis recti (HP:0001540)1.57520089
138Deformed tarsal bones (HP:0008119)1.57353335
139Flat acetabular roof (HP:0003180)1.57298173
140Atrophic scars (HP:0001075)1.57282756
141Ectopic anus (HP:0004397)1.56930701
142Back pain (HP:0003418)1.56401255
143Myelomeningocele (HP:0002475)1.56192781
144Triphalangeal thumb (HP:0001199)1.56040321
145Chorioretinal atrophy (HP:0000533)1.55125356
146Abnormality of the carotid arteries (HP:0005344)1.54611379
147Arteriovenous malformation (HP:0100026)1.47831696
148Disproportionate tall stature (HP:0001519)1.46892771
149Protruding ear (HP:0000411)1.46669672
150Hypoplastic pelvis (HP:0008839)1.46595944
151Progressive muscle weakness (HP:0003323)1.46344392
152Abnormality of DNA repair (HP:0003254)1.45966984
153Abnormal ossification of hand bones (HP:0005921)1.45103204
154Missing ribs (HP:0000921)1.44636108
155Hyperextensible skin (HP:0000974)1.42961955

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.36638378
2EIF2AK33.30209380
3WEE13.20729209
4CDC73.03327777
5MKNK12.84052319
6SIK32.66492510
7VRK22.33627958
8EIF2AK12.28848241
9TGFBR12.23799490
10SRPK12.08787260
11NME22.06525338
12TSSK62.06467004
13BRSK22.01537710
14STK161.88316801
15PASK1.85916320
16VRK11.83899532
17PAK41.76796565
18TAF11.71483970
19PDK21.65202052
20RPS6KB21.60649164
21PIM21.57938022
22CDK71.56788636
23EPHB21.56487169
24TTK1.51108887
25MAP2K31.50538428
26PKN21.47472097
27CDK91.47043318
28RPS6KA41.44946938
29NEK91.39685311
30ATR1.38350481
31DYRK31.38330480
32CDK81.36429556
33ACVR1B1.35956416
34BCR1.35249160
35FLT31.34489297
36PLK11.29635408
37PDGFRA1.25353851
38MKNK21.23073933
39AURKB1.22808573
40NEK11.21755574
41ERBB41.17731746
42LATS21.16775636
43ERN11.15529496
44LATS11.13818122
45SCYL21.09583863
46DYRK21.08670427
47STK101.07289846
48LRRK21.05004706
49NEK21.04773991
50PAK21.04156441
51TRIM281.03828098
52BTK1.02123268
53MAP3K81.01883578
54KSR11.01490755
55TGFBR21.01426787
56STK41.00386817
57TLK11.00063349
58TIE10.99921687
59PLK40.99440316
60EIF2AK20.99435690
61PLK30.98073716
62CHEK20.97880699
63TESK20.92993732
64BRAF0.92622275
65EEF2K0.90519151
66CLK10.89986650
67KDR0.86207479
68SIK10.83957606
69PTK20.83708781
70KIT0.81495510
71CDK40.80637341
72DDR20.80021352
73TEC0.79554917
74ERBB30.76451789
75PLK20.76231257
76CSNK1G10.73050514
77BRSK10.72641890
78PBK0.72126556
79MATK0.70588085
80TNIK0.70078073
81BRD40.69611332
82MAP3K100.69356408
83ZAK0.67831143
84DYRK1B0.67444316
85MET0.67134502
86CDK120.66364394
87CCNB10.65282918
88MAPKAPK50.65192512
89LIMK10.64946098
90CSNK1G30.63960078
91CHEK10.63306816
92STK30.62985317
93MYLK0.62917789
94ILK0.62812704
95MAP3K40.61166445
96BCKDK0.60182933
97STK38L0.59922471
98TTN0.59424285
99TRPM70.59265151
100NUAK10.58757419
101PNCK0.58472739
102ERBB20.55882253
103PAK10.54557096
104NME10.54513721
105NTRK10.53161587
106CSF1R0.52292952
107AURKA0.52145577
108ATM0.50972075
109AKT30.50669341
110PIM10.50637958
111CDK190.50074151
112CSNK1A1L0.49392441
113STK240.48802140
114CDK20.48110689
115CDK11A0.47550665
116CSNK2A10.46821416
117CDK60.45619859
118MAPKAPK30.45240162
119SMG10.45168432
120CSNK1E0.45036663
121MAP2K70.44713765
122CDK180.44474575
123CDK150.44371225
124LMTK20.44271754
125TESK10.43730770
126FGFR10.42849432
127ICK0.42812548
128MAP3K30.42581529
129CDK140.40626263
130CSNK1G20.39982218
131AKT20.39703440
132RPS6KA50.38318750
133MAP3K60.38165569
134CSNK2A20.37977399
135MAPKAPK20.37506914
136CDK10.36679770
137PRKDC0.36186245
138CHUK0.34725545

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.74396576
2Mismatch repair_Homo sapiens_hsa034303.60478635
3Ribosome_Homo sapiens_hsa030103.57716942
4Spliceosome_Homo sapiens_hsa030403.05794186
5Base excision repair_Homo sapiens_hsa034102.97191806
6RNA polymerase_Homo sapiens_hsa030202.69708664
7Cell cycle_Homo sapiens_hsa041102.63502104
8One carbon pool by folate_Homo sapiens_hsa006702.62753388
9Proteasome_Homo sapiens_hsa030502.60055103
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.59515160
11Nucleotide excision repair_Homo sapiens_hsa034202.54756366
12Homologous recombination_Homo sapiens_hsa034402.46703663
13RNA transport_Homo sapiens_hsa030132.41405482
14Pyrimidine metabolism_Homo sapiens_hsa002402.30997865
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.19070886
16Non-homologous end-joining_Homo sapiens_hsa034502.02733673
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.97310737
18Protein export_Homo sapiens_hsa030601.95388891
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.86464451
20Steroid biosynthesis_Homo sapiens_hsa001001.77951500
21RNA degradation_Homo sapiens_hsa030181.72376859
22Basal transcription factors_Homo sapiens_hsa030221.69328188
23Sulfur relay system_Homo sapiens_hsa041221.66850305
24Fanconi anemia pathway_Homo sapiens_hsa034601.65585140
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.61476491
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.55463472
27Pyruvate metabolism_Homo sapiens_hsa006201.46303722
28N-Glycan biosynthesis_Homo sapiens_hsa005101.34266700
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29782281
30mRNA surveillance pathway_Homo sapiens_hsa030151.26987188
31Arginine biosynthesis_Homo sapiens_hsa002201.26037005
32Propanoate metabolism_Homo sapiens_hsa006401.25829377
33p53 signaling pathway_Homo sapiens_hsa041151.24218290
34Purine metabolism_Homo sapiens_hsa002301.24145562
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.19899905
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17770405
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16700609
38Basal cell carcinoma_Homo sapiens_hsa052171.16168808
39ECM-receptor interaction_Homo sapiens_hsa045121.14197477
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12237342
41Systemic lupus erythematosus_Homo sapiens_hsa053221.04257895
42Galactose metabolism_Homo sapiens_hsa000521.02507534
43MicroRNAs in cancer_Homo sapiens_hsa052061.01227492
44Sulfur metabolism_Homo sapiens_hsa009201.00848398
45Arginine and proline metabolism_Homo sapiens_hsa003300.99304117
46Epstein-Barr virus infection_Homo sapiens_hsa051690.94026470
47Small cell lung cancer_Homo sapiens_hsa052220.91848659
48TGF-beta signaling pathway_Homo sapiens_hsa043500.89983761
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89392340
50Glutathione metabolism_Homo sapiens_hsa004800.88228327
51Parkinsons disease_Homo sapiens_hsa050120.87744811
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87106859
53HTLV-I infection_Homo sapiens_hsa051660.85145105
54Herpes simplex infection_Homo sapiens_hsa051680.84654499
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.84276349
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83072302
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82823433
58Oxidative phosphorylation_Homo sapiens_hsa001900.82010711
59Viral carcinogenesis_Homo sapiens_hsa052030.81547116
60Thyroid cancer_Homo sapiens_hsa052160.78959986
61Fatty acid metabolism_Homo sapiens_hsa012120.78849108
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78809706
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76249514
64Chronic myeloid leukemia_Homo sapiens_hsa052200.74826008
65Hippo signaling pathway_Homo sapiens_hsa043900.74528405
66Legionellosis_Homo sapiens_hsa051340.71610416
67Notch signaling pathway_Homo sapiens_hsa043300.71114625
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70469952
69Shigellosis_Homo sapiens_hsa051310.69995962
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69190166
71Folate biosynthesis_Homo sapiens_hsa007900.68448158
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67634222
73Focal adhesion_Homo sapiens_hsa045100.66494446
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66173133
75Peroxisome_Homo sapiens_hsa041460.64799064
76Butanoate metabolism_Homo sapiens_hsa006500.64335846
77Antigen processing and presentation_Homo sapiens_hsa046120.63449913
78PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63404159
79Biosynthesis of amino acids_Homo sapiens_hsa012300.62205555
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.60349980
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.60245603
82Bladder cancer_Homo sapiens_hsa052190.59199255
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58484214
84Proteoglycans in cancer_Homo sapiens_hsa052050.57479874
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56842910
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.56820753
87Malaria_Homo sapiens_hsa051440.56647375
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56443687
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.54935341
90Vitamin digestion and absorption_Homo sapiens_hsa049770.53919081
91Hedgehog signaling pathway_Homo sapiens_hsa043400.51878095
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51766077
93Pathways in cancer_Homo sapiens_hsa052000.50136472
94Complement and coagulation cascades_Homo sapiens_hsa046100.50015030
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49552404
96Selenocompound metabolism_Homo sapiens_hsa004500.46428697
97Fatty acid elongation_Homo sapiens_hsa000620.46192560
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45688283
99Arachidonic acid metabolism_Homo sapiens_hsa005900.45385913
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.44756182
101Viral myocarditis_Homo sapiens_hsa054160.44505587
102Hepatitis B_Homo sapiens_hsa051610.44273108
103Oocyte meiosis_Homo sapiens_hsa041140.44162142
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43018021
105Platelet activation_Homo sapiens_hsa046110.42689370
106Vitamin B6 metabolism_Homo sapiens_hsa007500.41601463
107Apoptosis_Homo sapiens_hsa042100.41281669
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40734320
109Alzheimers disease_Homo sapiens_hsa050100.39959917
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38887257
111Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37801968
112Primary bile acid biosynthesis_Homo sapiens_hsa001200.37402042
113Retinol metabolism_Homo sapiens_hsa008300.36453652
114Colorectal cancer_Homo sapiens_hsa052100.35203221
115Melanoma_Homo sapiens_hsa052180.34088160
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.32851329
117Carbon metabolism_Homo sapiens_hsa012000.32399947
1182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.29741920
119Wnt signaling pathway_Homo sapiens_hsa043100.29346890
120Hematopoietic cell lineage_Homo sapiens_hsa046400.28761633
121Adherens junction_Homo sapiens_hsa045200.28680342
122Other glycan degradation_Homo sapiens_hsa005110.28545519
123Lysine degradation_Homo sapiens_hsa003100.27530737
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.27111298
125Prostate cancer_Homo sapiens_hsa052150.27056397
126Pentose phosphate pathway_Homo sapiens_hsa000300.27022904
127Alcoholism_Homo sapiens_hsa050340.26978155
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26919009
129HIF-1 signaling pathway_Homo sapiens_hsa040660.26363940
130Protein digestion and absorption_Homo sapiens_hsa049740.25732748
131Measles_Homo sapiens_hsa051620.25536805
132Huntingtons disease_Homo sapiens_hsa050160.25446486
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.25358047
134Metabolic pathways_Homo sapiens_hsa011000.24374842

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