ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of lipid storage (GO:0010888)	7.32199969
2	positive regulation of glomerulus development (GO:0090193)	6.92649512
3	regulation of transforming growth factor beta1 production (GO:0032908)	6.91509915
4	regulation of memory T cell differentiation (GO:0043380)	6.64283927
5	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	6.40430875
6	pantothenate metabolic process (GO:0015939)	5.68383915
7	regulation of MHC class I biosynthetic process (GO:0045343)	5.42959468
8	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	5.36478591
9	regulation of cell proliferation involved in kidney development (GO:1901722)	5.33381208
10	cytoplasmic mRNA processing body assembly (GO:0033962)	5.29031877
11	transepithelial transport (GO:0070633)	5.22439674
12	chronic inflammatory response (GO:0002544)	5.19122814
13	acute inflammatory response (GO:0002526)	5.00234270
14	positive regulation of transforming growth factor beta production (GO:0071636)	4.95672084
15	acute-phase response (GO:0006953)	4.69270338
16	positive regulation of T cell differentiation in thymus (GO:0033089)	4.64194873
17	regulation of macrophage derived foam cell differentiation (GO:0010743)	4.60956319
18	regulation of glomerulus development (GO:0090192)	4.55177326
19	regulation of establishment of cell polarity (GO:2000114)	4.49207169
20	regulation of cellular extravasation (GO:0002691)	4.35522333
21	protein K11-linked deubiquitination (GO:0035871)	4.26353144
22	sex differentiation (GO:0007548)	4.23591327
23	kynurenine metabolic process (GO:0070189)	4.13487428
24	acrosome assembly (GO:0001675)	4.10226794
25	negative regulation of multicellular organism growth (GO:0040015)	4.06728826
26	indole-containing compound catabolic process (GO:0042436)	3.85843220
27	indolalkylamine catabolic process (GO:0046218)	3.85843220
28	tryptophan catabolic process (GO:0006569)	3.85843220
29	protein autoprocessing (GO:0016540)	3.84759382
30	regulation of establishment or maintenance of cell polarity (GO:0032878)	3.79767315
31	seminiferous tubule development (GO:0072520)	3.72460885
32	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.67652863
33	L-phenylalanine metabolic process (GO:0006558)	3.67652863
34	aromatic amino acid family catabolic process (GO:0009074)	3.66875646
35	somite rostral/caudal axis specification (GO:0032525)	3.66006904
36	tryptophan metabolic process (GO:0006568)	3.64088544
37	cobalamin metabolic process (GO:0009235)	3.62560782
38	regulation of transforming growth factor beta production (GO:0071634)	3.59972874
39	androgen biosynthetic process (GO:0006702)	3.56427651
40	regulation of lipid storage (GO:0010883)	3.56152400
41	cerebellar Purkinje cell differentiation (GO:0021702)	3.55087191
42	regulation of interleukin-13 production (GO:0032656)	3.52538456
43	cellular response to calcium ion (GO:0071277)	3.48876200
44	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.47863988
45	defense response to Gram-positive bacterium (GO:0050830)	3.46330240
46	L-phenylalanine catabolic process (GO:0006559)	3.45537125
47	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.45537125
48	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.43235755
49	regulation of interleukin-5 production (GO:0032674)	3.39793352
50	tyrosine metabolic process (GO:0006570)	3.36053727
51	cholesterol catabolic process (GO:0006707)	3.32899484
52	sterol catabolic process (GO:0016127)	3.32899484
53	thyroid hormone generation (GO:0006590)	3.28857589
54	lipid particle organization (GO:0034389)	3.28796570
55	lactate metabolic process (GO:0006089)	3.20754009
56	complement activation, classical pathway (GO:0006958)	3.20039008
57	L-fucose catabolic process (GO:0042355)	3.18317089
58	fucose catabolic process (GO:0019317)	3.18317089
59	L-fucose metabolic process (GO:0042354)	3.18317089
60	regulation of inflammatory response to antigenic stimulus (GO:0002861)	3.17989091
61	temperature homeostasis (GO:0001659)	3.15016540
62	thyroid hormone metabolic process (GO:0042403)	3.11805230
63	cellular biogenic amine catabolic process (GO:0042402)	3.11356688
64	amine catabolic process (GO:0009310)	3.11356688
65	regulation of acyl-CoA biosynthetic process (GO:0050812)	3.11235905
66	removal of superoxide radicals (GO:0019430)	3.11203410
67	cellular response to superoxide (GO:0071451)	3.11203410
68	cellular response to oxygen radical (GO:0071450)	3.11203410
69	epithelial structure maintenance (GO:0010669)	3.09217856
70	maintenance of gastrointestinal epithelium (GO:0030277)	3.09151522
71	water-soluble vitamin biosynthetic process (GO:0042364)	3.01951072
72	response to interferon-beta (GO:0035456)	2.94346410
73	sperm capacitation (GO:0048240)	2.94069793
74	positive regulation of vasculogenesis (GO:2001214)	2.91814313
75	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.90264725
76	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)	2.89595826
77	regulation of transforming growth factor beta2 production (GO:0032909)	2.88659130
78	nucleoside diphosphate catabolic process (GO:0009134)	2.86417821
79	regulation of interleukin-8 production (GO:0032677)	2.84010617
80	positive regulation of male gonad development (GO:2000020)	2.83611651
81	aromatic amino acid family metabolic process (GO:0009072)	2.82959443
82	regulation of metalloenzyme activity (GO:0048552)	2.82632090
83	androgen metabolic process (GO:0008209)	2.74019741
84	negative regulation of type 2 immune response (GO:0002829)	2.73869516
85	regulation of vasculogenesis (GO:2001212)	2.70768675
86	positive regulation of dendrite development (GO:1900006)	2.69967691
87	ADP metabolic process (GO:0046031)	2.69850454
88	regulation of cofactor metabolic process (GO:0051193)	2.67489015
89	regulation of coenzyme metabolic process (GO:0051196)	2.67489015
90	regulation of male gonad development (GO:2000018)	2.67019044
91	centrosome duplication (GO:0051298)	2.65679292
92	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	2.64587782
93	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	2.64587782
94	regulation of natural killer cell differentiation (GO:0032823)	2.63666996
95	indolalkylamine metabolic process (GO:0006586)	2.61576300
96	complement activation (GO:0006956)	2.58036130
97	opsonization (GO:0008228)	13.9249415
98	response to lead ion (GO:0010288)	11.3902132
99	regulation of interleukin-8 secretion (GO:2000482)	10.5152166
100	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	10.2696152

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.04215663
2	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.78609832
3	VDR_22108803_ChIP-Seq_LS180_Human	2.78160846
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.73188410
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.67802217
6	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.44677553
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.42288422
8	SUZ12_27294783_Chip-Seq_NPCs_Mouse	2.40398762
9	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.34291514
10	AR_21572438_ChIP-Seq_LNCaP_Human	2.33276575
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.30519055
12	NFE2_27457419_Chip-Seq_LIVER_Mouse	2.21782902
13	EZH2_27294783_Chip-Seq_NPCs_Mouse	2.20043347
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.19468898
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.15799634
16	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	2.13118250
17	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.09219346
18	TAF15_26573619_Chip-Seq_HEK293_Human	2.08850817
19	FUS_26573619_Chip-Seq_HEK293_Human	1.97633228
20	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.89857692
21	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.89290653
22	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.86243113
23	P300_19829295_ChIP-Seq_ESCs_Human	1.83231703
24	TP53_16413492_ChIP-PET_HCT116_Human	1.80429368
25	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.79669068
26	BCAT_22108803_ChIP-Seq_LS180_Human	1.76862999
27	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.74659940
28	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.72313358
29	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.70869552
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.70313840
31	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.70233517
32	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.66456180
33	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.65520907
34	P53_22387025_ChIP-Seq_ESCs_Mouse	1.64208461
35	ER_23166858_ChIP-Seq_MCF-7_Human	1.62643555
36	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.57860780
37	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.56814306
38	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.56515917
39	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.55163023
40	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.54751022
41	ZNF274_21170338_ChIP-Seq_K562_Hela	1.52006627
42	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.51592123
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.51095101
44	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.50716021
45	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.49378797
46	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.49149404
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.45875784
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.45875784
49	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.44294323
50	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.43604453
51	P300_18555785_Chip-Seq_ESCs_Mouse	1.43392531
52	TCF4_22108803_ChIP-Seq_LS180_Human	1.42775466
53	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.42669344
54	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.42396770
55	SMAD1_18555785_Chip-Seq_ESCs_Mouse	1.41872236
56	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.41392186
57	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.41308855
58	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.41036133
59	EWS_26573619_Chip-Seq_HEK293_Human	1.40873974
60	CJUN_26792858_Chip-Seq_BT549_Human	1.40774584
61	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.39245394
62	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.34095671
63	ESRRB_18555785_Chip-Seq_ESCs_Mouse	1.32735473
64	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.32546350
65	STAT3_23295773_ChIP-Seq_U87_Human	1.32221128
66	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.31966780
67	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.31743811
68	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.31736083
69	AR_25329375_ChIP-Seq_VCAP_Human	1.31122434
70	CDX2_22108803_ChIP-Seq_LS180_Human	1.29373865
71	PHF8_20622853_ChIP-Seq_HELA_Human	1.29282480
72	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.27660292
73	TBL1_22424771_ChIP-Seq_293T_Human	1.27483436
74	ZFX_18555785_Chip-Seq_ESCs_Mouse	1.26442777
75	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.26011355
76	GATA4_25053715_ChIP-Seq_YYC3_Human	1.25597855
77	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.25159226
78	SOX2_19829295_ChIP-Seq_ESCs_Human	1.24694656
79	NANOG_19829295_ChIP-Seq_ESCs_Human	1.24694656
80	ELK1_19687146_ChIP-ChIP_HELA_Human	1.24190106
81	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.22856452
82	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.22454827
83	IGF1R_20145208_ChIP-Seq_DFB_Human	1.22420178
84	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.21624214
85	NFYA_21822215_ChIP-Seq_K562_Human	1.21512339
86	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.21139219
87	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	1.21090119
88	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.20734801
89	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.19069002
90	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.19041823
91	NFYB_21822215_ChIP-Seq_K562_Human	1.18152396
92	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.17880427
93	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.17646656
94	SMAD4_21799915_ChIP-Seq_A2780_Human	1.16591829
95	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.16166887
96	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.15950100
97	ETV1_20927104_ChIP-Seq_GIST48_Human	1.15753791
98	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.14237325
99	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.14237325
100	SOX2_20726797_ChIP-Seq_SW620_Human	1.13794922

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	5.78082257
2	MP0002138_abnormal_hepatobiliary_system	5.52580038
3	MP0010386_abnormal_urinary_bladder	4.92267336
4	MP0003252_abnormal_bile_duct	4.88618936
5	MP0004043_abnormal_pH_regulation	3.49447206
6	MP0003950_abnormal_plasma_membrane	3.37395253
7	MP0003300_gastrointestinal_ulcer	3.26792289
8	MP0001873_stomach_inflammation	3.12288586
9	MP0002928_abnormal_bile_duct	3.11415853
10	MP0002163_abnormal_gland_morphology	2.91036999
11	MP0005171_absent_coat_pigmentation	2.79147878
12	MP0002876_abnormal_thyroid_physiology	2.68055670
13	MP0002277_abnormal_respiratory_mucosa	2.60393067
14	MP0005085_abnormal_gallbladder_physiolo	2.48497137
15	MP0005084_abnormal_gallbladder_morpholo	2.45386857
16	MP0005365_abnormal_bile_salt	2.32513123
17	MP0006054_spinal_hemorrhage	2.15147145
18	MP0002638_abnormal_pupillary_reflex	2.09371042
19	MP0000569_abnormal_digit_pigmentation	1.91864515
20	MP0009697_abnormal_copulation	1.81946774
21	MP0000613_abnormal_salivary_gland	1.75964711
22	MP0002736_abnormal_nociception_after	1.58114073
23	MP0005379_endocrine/exocrine_gland_phen	1.57761681
24	MP0003646_muscle_fatigue	1.51026921
25	MP0003943_abnormal_hepatobiliary_system	1.49950305
26	MP0004147_increased_porphyrin_level	1.47369145
27	MP0000372_irregular_coat_pigmentation	1.46715260
28	MP0002139_abnormal_hepatobiliary_system	1.46707929
29	MP0001666_abnormal_nutrient_absorption	1.44885826
30	MP0002132_abnormal_respiratory_system	1.44249942
31	MP0005410_abnormal_fertilization	1.41869821
32	MP0005408_hypopigmentation	1.41706906
33	MP0001986_abnormal_taste_sensitivity	1.41463842
34	MP0005253_abnormal_eye_physiology	1.37567562
35	MP0006035_abnormal_mitochondrial_morpho	1.36537685
36	MP0005220_abnormal_exocrine_pancreas	1.34148627
37	MP0004233_abnormal_muscle_weight	1.31208755
38	MP0005670_abnormal_white_adipose	1.28028030
39	MP0001485_abnormal_pinna_reflex	1.25560353
40	MP0008961_abnormal_basal_metabolism	1.24591985
41	MP0003718_maternal_effect	1.23801803
42	MP0003011_delayed_dark_adaptation	1.22641104
43	MP0005174_abnormal_tail_pigmentation	1.20027368
44	MP0000371_diluted_coat_color	1.18404696
45	MP0003186_abnormal_redox_activity	1.16618446
46	MP0005551_abnormal_eye_electrophysiolog	1.12420149
47	MP0000427_abnormal_hair_cycle	1.06298251
48	MP0003890_abnormal_embryonic-extraembry	1.05743500
49	MP0001664_abnormal_digestion	1.04865509
50	MP0010234_abnormal_vibrissa_follicle	0.99392254
51	MP0003136_yellow_coat_color	0.97013588
52	MP0001663_abnormal_digestive_system	0.96324613
53	MP0000538_abnormal_urinary_bladder	0.94696747
54	MP0001486_abnormal_startle_reflex	0.94385072
55	MP0006072_abnormal_retinal_apoptosis	0.93845496
56	MP0005310_abnormal_salivary_gland	0.93749491
57	MP0008872_abnormal_physiological_respon	0.89059859
58	MP0004264_abnormal_extraembryonic_tissu	0.88896355
59	MP0001756_abnormal_urination	0.86300310
60	MP0006036_abnormal_mitochondrial_physio	0.86203088
61	MP0002127_abnormal_cardiovascular_syste	0.86143039
62	MP0001324_abnormal_eye_pigmentation	0.83666446
63	MP0010678_abnormal_skin_adnexa	0.83406543
64	MP0005330_cardiomyopathy	0.82233438
65	MP0001501_abnormal_sleep_pattern	0.77508917
66	MP0005332_abnormal_amino_acid	0.77289460
67	MP0005395_other_phenotype	0.73659070
68	MP0004215_abnormal_myocardial_fiber	0.70386161
69	MP0000383_abnormal_hair_follicle	0.68687326
70	MP0009764_decreased_sensitivity_to	0.67159150
71	MP0003868_abnormal_feces_composition	0.66674725
72	MP0002095_abnormal_skin_pigmentation	0.65363785
73	MP0001177_atelectasis	0.63767342
74	MP0009643_abnormal_urine_homeostasis	0.61360857
75	MP0002972_abnormal_cardiac_muscle	0.60403120
76	MP0005595_abnormal_vascular_smooth	0.59966248
77	MP0005636_abnormal_mineral_homeostasis	0.59797306
78	MP0002282_abnormal_trachea_morphology	0.58693843
79	MP0003724_increased_susceptibility_to	0.58047941
80	MP0005647_abnormal_sex_gland	0.56399567
81	MP0001270_distended_abdomen	0.56372340
82	MP0001968_abnormal_touch/_nociception	0.55609696
83	MP0004085_abnormal_heartbeat	0.54691865
84	MP0002089_abnormal_postnatal_growth/wei	0.51311489
85	MP0005360_urolithiasis	0.51190313
86	MP0001879_abnormal_lymphatic_vessel	0.50943552
87	MP0005646_abnormal_pituitary_gland	0.49660395
88	MP0006138_congestive_heart_failure	0.48644330
89	MP0009785_altered_susceptibility_to	0.48103425
90	MP0002233_abnormal_nose_morphology	0.47847048
91	MP0005167_abnormal_blood-brain_barrier	0.47261167
92	MP0008875_abnormal_xenobiotic_pharmacok	0.45789382
93	MP0004484_altered_response_of	0.45639791
94	MP0003936_abnormal_reproductive_system	0.45566388
95	MP0002837_dystrophic_cardiac_calcinosis	0.44776695
96	MP0005083_abnormal_biliary_tract	0.43779418
97	MP0005381_digestive/alimentary_phenotyp	0.43741359
98	MP0002168_other_aberrant_phenotype	0.42919354
99	MP0002166_altered_tumor_susceptibility	0.41926734
100	MP0005319_abnormal_enzyme/_coenzyme	0.40455527

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Prostate neoplasm (HP:0100787)	5.62984747
2	Genetic anticipation (HP:0003743)	5.57993925
3	Action tremor (HP:0002345)	5.27234166
4	Rectal prolapse (HP:0002035)	4.98383417
5	Ileus (HP:0002595)	4.62918083
6	Dysmetric saccades (HP:0000641)	3.97193973
7	Pendular nystagmus (HP:0012043)	3.95957702
8	Gaze-evoked nystagmus (HP:0000640)	3.77600826
9	Abnormality of macular pigmentation (HP:0008002)	3.75303957
10	Abnormality of the prostate (HP:0008775)	3.64066077
11	Progressive cerebellar ataxia (HP:0002073)	3.55559388
12	Exocrine pancreatic insufficiency (HP:0001738)	3.41272789
13	Abnormality of the hepatic vasculature (HP:0006707)	3.37948639
14	Abnormality of male internal genitalia (HP:0000022)	3.34120697
15	Azoospermia (HP:0000027)	3.27973483
16	Male infertility (HP:0003251)	3.17699714
17	Medial flaring of the eyebrow (HP:0010747)	3.16517588
18	Severe visual impairment (HP:0001141)	3.12654578
19	Progressive inability to walk (HP:0002505)	3.07170037
20	Abnormal biliary tract morphology (HP:0012440)	3.06921243
21	Inability to walk (HP:0002540)	2.95196853
22	Abnormal spermatogenesis (HP:0008669)	2.86948228
23	Urinary bladder sphincter dysfunction (HP:0002839)	2.79580344
24	Absence seizures (HP:0002121)	2.79085222
25	Large for gestational age (HP:0001520)	2.76238595
26	Spinal muscular atrophy (HP:0007269)	2.75105450
27	Postnatal microcephaly (HP:0005484)	2.74690957
28	Congenital, generalized hypertrichosis (HP:0004540)	2.71981740
29	Stomach cancer (HP:0012126)	2.71750022
30	Impaired proprioception (HP:0010831)	2.68660561
31	Albinism (HP:0001022)	2.67841809
32	Abnormality of the renal cortex (HP:0011035)	2.67265323
33	Neonatal short-limb short stature (HP:0008921)	2.62431342
34	Abnormal pancreas size (HP:0012094)	2.57961913
35	Vascular calcification (HP:0004934)	2.50736098
36	Dysdiadochokinesis (HP:0002075)	2.49285445
37	Back pain (HP:0003418)	2.47990604
38	Degeneration of anterior horn cells (HP:0002398)	2.45574388
39	Abnormality of the anterior horn cell (HP:0006802)	2.45574388
40	Hypochromic microcytic anemia (HP:0004840)	2.44475310
41	Renal cortical cysts (HP:0000803)	2.43542520
42	Pancreatic cysts (HP:0001737)	2.41566634
43	Hyperventilation (HP:0002883)	2.39706482
44	Impaired vibratory sensation (HP:0002495)	2.38997073
45	Postural tremor (HP:0002174)	2.32338096
46	Decreased muscle mass (HP:0003199)	2.28410779
47	Follicular hyperkeratosis (HP:0007502)	2.27751796
48	Abnormality of the right ventricle (HP:0001707)	2.27119239
49	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.26057817
50	True hermaphroditism (HP:0010459)	2.25513357
51	Abnormality of chloride homeostasis (HP:0011422)	2.24170105
52	Abnormality of the renal medulla (HP:0100957)	2.18931023
53	Abnormality of the nasal septum (HP:0000419)	2.17605503
54	11 pairs of ribs (HP:0000878)	2.17580166
55	Congenital primary aphakia (HP:0007707)	2.13446242
56	Dialeptic seizures (HP:0011146)	2.11946273
57	Male pseudohermaphroditism (HP:0000037)	2.11165550
58	Aplasia/hypoplasia of the uterus (HP:0008684)	2.10791753
59	Cardiovascular calcification (HP:0011915)	2.10738221
60	Poor head control (HP:0002421)	2.08529113
61	Posterior subcapsular cataract (HP:0007787)	2.07159312
62	Sex reversal (HP:0012245)	2.06170390
63	Abnormal sex determination (HP:0012244)	2.06170390
64	Macular degeneration (HP:0000608)	2.05259895
65	Gait imbalance (HP:0002141)	2.04513185
66	Chorioretinal atrophy (HP:0000533)	2.03808540
67	Poor eye contact (HP:0000817)	2.01992605
68	Febrile seizures (HP:0002373)	2.01974618
69	Goiter (HP:0000853)	2.00203971
70	Congenital sensorineural hearing impairment (HP:0008527)	1.93808080
71	Decreased central vision (HP:0007663)	1.92717965
72	Severe Myopia (HP:0011003)	1.91626526
73	Glucose intolerance (HP:0000833)	1.90397753
74	Hypoplasia of the uterus (HP:0000013)	1.89776503
75	Steatorrhea (HP:0002570)	1.88188707
76	Duplicated collecting system (HP:0000081)	1.85637489
77	Hypobetalipoproteinemia (HP:0003563)	1.84748761
78	Infertility (HP:0000789)	1.83350325
79	Retinitis pigmentosa (HP:0000510)	1.81813834
80	Hip dysplasia (HP:0001385)	1.81104436
81	Abnormality of methionine metabolism (HP:0010901)	1.80282510
82	Hypoproteinemia (HP:0003075)	1.79605646
83	Renal tubular acidosis (HP:0001947)	1.79092820
84	Fair hair (HP:0002286)	1.78322860
85	Hypoplasia of the fovea (HP:0007750)	1.77816992
86	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.77816992
87	Chronic diarrhea (HP:0002028)	1.74230319
88	Hypoplastic iliac wings (HP:0002866)	1.74124617
89	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.73345213
90	Slow saccadic eye movements (HP:0000514)	1.73031746
91	Abnormality of proline metabolism (HP:0010907)	1.71481365
92	Hydroxyprolinuria (HP:0003080)	1.71481365
93	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.71027153
94	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.71027153
95	Small hand (HP:0200055)	1.70933123
96	Nephrogenic diabetes insipidus (HP:0009806)	1.70795450
97	Tubulointerstitial nephritis (HP:0001970)	1.70465664
98	Thyroiditis (HP:0100646)	1.68548822
99	Acute necrotizing encephalopathy (HP:0006965)	1.68178170
100	Biliary tract neoplasm (HP:0100574)	1.67683727

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LMTK2	8.61129459
2	OXSR1	4.63798018
3	FRK	3.65515527
4	ZAK	3.37385580
5	STK39	3.19994001
6	BRSK2	2.70611670
7	PBK	2.64155147
8	ERBB4	2.63239987
9	MST4	2.57792971
10	CDK19	2.48118519
11	PDK2	2.23316140
12	PRKG2	2.07950565
13	GRK1	1.93338190
14	INSRR	1.85424061
15	MAP3K7	1.80937255
16	EIF2AK1	1.80735446
17	BMPR1B	1.78171375
18	WEE1	1.73887559
19	EIF2AK3	1.69490359
20	ACVR1B	1.57289438
21	STK38L	1.43633192
22	MAP3K14	1.22088719
23	PKN2	1.20476974
24	VRK2	1.09485107
25	PIK3CA	1.04747675
26	FLT3	1.03834622
27	BRSK1	1.03099213
28	MKNK2	1.00496705
29	TIE1	0.99056475
30	DYRK3	0.98992328
31	TRIM28	0.96670301
32	FER	0.96321424
33	TNIK	0.95317613
34	NLK	0.89208382
35	FGFR1	0.86055126
36	MAP3K13	0.85485774
37	MAP3K2	0.81240483
38	VRK1	0.80065704
39	BCKDK	0.77194835
40	BCR	0.72995681
41	PAK3	0.72214665
42	MELK	0.69324806
43	PASK	0.69148170
44	PRKAA2	0.68726131
45	PLK3	0.67844078
46	TSSK6	0.63604899
47	NME1	0.62990226
48	STK3	0.59261918
49	TGFBR2	0.59247866
50	TTK	0.57929364
51	PRKCQ	0.55963216
52	ROCK1	0.55754728
53	ERBB3	0.53893527
54	CASK	0.49011821
55	ADRBK2	0.48969380
56	TEC	0.48106947
57	ERBB2	0.45047009
58	AKT3	0.43744736
59	TAF1	0.43469847
60	NTRK2	0.43306408
61	RPS6KB2	0.41505502
62	CHUK	0.39415148
63	PRKCE	0.39003588
64	TAOK3	0.38934937
65	MAP3K12	0.38931968
66	IKBKB	0.38807295
67	PRKAA1	0.38721990
68	NEK1	0.36512619
69	MKNK1	0.31789775
70	WNK3	0.31339884
71	STK10	0.30995356
72	MAP2K6	0.27032127
73	TLK1	0.26876773
74	PNCK	0.26063779
75	EIF2AK2	0.25932686
76	PTK2B	0.25608874
77	TGFBR1	0.25291637
78	TNK2	0.25228883
79	STK11	0.24535242
80	CDK8	0.24508600
81	PRKG1	0.23682458
82	EPHA2	0.23636902
83	NEK9	0.22735595
84	TRPM7	0.21875322
85	AKT2	0.21311523
86	PLK1	0.21274117
87	SIK3	0.20977842
88	CHEK1	0.20745470
89	IGF1R	0.19982667
90	STK4	0.19395713
91	MARK3	0.19138808
92	ABL1	0.18928841
93	OBSCN	0.18061389
94	NUAK1	0.17696343
95	MAP2K2	0.16872037
96	PIK3CG	0.16211550
97	PDK1	0.16119163
98	CAMKK2	0.15775566
99	EPHB2	0.15634580
100	BMPR2	0.14958832

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	4.05657738
2	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.54292168
3	Vitamin B6 metabolism_Homo sapiens_hsa00750	3.09585143
4	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.70016791
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.66023549
6	Butanoate metabolism_Homo sapiens_hsa00650	2.60718917
7	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.34487324
8	Sulfur metabolism_Homo sapiens_hsa00920	2.30610912
9	Glutathione metabolism_Homo sapiens_hsa00480	2.26305360
10	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.16173151
11	Propanoate metabolism_Homo sapiens_hsa00640	2.15377436
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.12739300
13	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.10982432
14	Thyroid hormone synthesis_Homo sapiens_hsa04918	2.00493249
15	Pancreatic secretion_Homo sapiens_hsa04972	1.98783491
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.90075175
17	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.89483323
18	Caffeine metabolism_Homo sapiens_hsa00232	1.83592465
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.82158436
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.68359221
21	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.54191756
22	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.52871804
23	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.52516144
24	Non-homologous end-joining_Homo sapiens_hsa03450	1.52391675
25	Proteasome_Homo sapiens_hsa03050	1.46582451
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.46060320
27	Retinol metabolism_Homo sapiens_hsa00830	1.43156712
28	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.41595182
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.39539680
30	Tight junction_Homo sapiens_hsa04530	1.38997557
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.35937625
32	Mineral absorption_Homo sapiens_hsa04978	1.34173754
33	Protein export_Homo sapiens_hsa03060	1.30506637
34	Bile secretion_Homo sapiens_hsa04976	1.30310729
35	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.30084923
36	RNA polymerase_Homo sapiens_hsa03020	1.26767907
37	Chemical carcinogenesis_Homo sapiens_hsa05204	1.24792828
38	Circadian rhythm_Homo sapiens_hsa04710	1.24082134
39	RNA degradation_Homo sapiens_hsa03018	1.20353380
40	Homologous recombination_Homo sapiens_hsa03440	1.19156941
41	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.18752046
42	ABC transporters_Homo sapiens_hsa02010	1.16535294
43	Phototransduction_Homo sapiens_hsa04744	1.16381560
44	Leukocyte transendothelial migration_Homo sapiens_hsa04670	1.14280831
45	Olfactory transduction_Homo sapiens_hsa04740	1.10477358
46	Basal transcription factors_Homo sapiens_hsa03022	1.00907443
47	African trypanosomiasis_Homo sapiens_hsa05143	0.94973964
48	One carbon pool by folate_Homo sapiens_hsa00670	0.92189096
49	Pyruvate metabolism_Homo sapiens_hsa00620	0.91601271
50	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.89123220
51	Fat digestion and absorption_Homo sapiens_hsa04975	0.87374604
52	Hepatitis C_Homo sapiens_hsa05160	0.86212274
53	Sphingolipid metabolism_Homo sapiens_hsa00600	0.85627844
54	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.84339145
55	Parkinsons disease_Homo sapiens_hsa05012	0.79552219
56	Oxidative phosphorylation_Homo sapiens_hsa00190	0.77074417
57	TNF signaling pathway_Homo sapiens_hsa04668	0.73066764
58	Nitrogen metabolism_Homo sapiens_hsa00910	0.71930218
59	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.68534056
60	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.65254493
61	Complement and coagulation cascades_Homo sapiens_hsa04610	0.65026040
62	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.64268910
63	Peroxisome_Homo sapiens_hsa04146	0.64132147
64	Glycerolipid metabolism_Homo sapiens_hsa00561	0.64056793
65	Gastric acid secretion_Homo sapiens_hsa04971	0.64024983
66	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.62034917
67	Fanconi anemia pathway_Homo sapiens_hsa03460	0.54903611
68	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.54785264
69	Fatty acid degradation_Homo sapiens_hsa00071	0.53053096
70	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.52588291
71	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.50836194
72	Histidine metabolism_Homo sapiens_hsa00340	0.48905931
73	Huntingtons disease_Homo sapiens_hsa05016	0.47698344
74	Legionellosis_Homo sapiens_hsa05134	0.47249009
75	Protein digestion and absorption_Homo sapiens_hsa04974	0.46800286
76	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.46705655
77	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.46296813
78	Steroid biosynthesis_Homo sapiens_hsa00100	0.46026518
79	Regulation of autophagy_Homo sapiens_hsa04140	0.45151943
80	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.44330690
81	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.44052566
82	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.43080115
83	Malaria_Homo sapiens_hsa05144	0.41825860
84	Arginine and proline metabolism_Homo sapiens_hsa00330	0.38763813
85	Salivary secretion_Homo sapiens_hsa04970	0.37117178
86	beta-Alanine metabolism_Homo sapiens_hsa00410	0.36916992
87	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.36605571
88	Vibrio cholerae infection_Homo sapiens_hsa05110	0.36119343
89	Lysine degradation_Homo sapiens_hsa00310	0.34285257
90	Metabolic pathways_Homo sapiens_hsa01100	0.34146516
91	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.33412614
92	Purine metabolism_Homo sapiens_hsa00230	0.33160715
93	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.31566476
94	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.28732306
95	Fatty acid metabolism_Homo sapiens_hsa01212	0.28394857
96	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.27613795
97	Adherens junction_Homo sapiens_hsa04520	0.27098988
98	Mismatch repair_Homo sapiens_hsa03430	0.25639968
99	Alzheimers disease_Homo sapiens_hsa05010	0.25459807
100	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.23153135

KDELC1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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