KDELR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.15111825
2Golgi transport vesicle coating (GO:0048200)5.15111825
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.57898358
4L-phenylalanine metabolic process (GO:0006558)4.57898358
5planar cell polarity pathway involved in neural tube closure (GO:0090179)4.48917636
6L-phenylalanine catabolic process (GO:0006559)4.34855737
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.34855737
8sulfur amino acid catabolic process (GO:0000098)4.26943660
9lysine metabolic process (GO:0006553)4.25814819
10lysine catabolic process (GO:0006554)4.25814819
114-hydroxyproline metabolic process (GO:0019471)4.23859720
12alpha-linolenic acid metabolic process (GO:0036109)4.16320787
13regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.13766705
14protein maturation by protein folding (GO:0022417)4.12549805
15cysteine metabolic process (GO:0006534)4.10484367
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.93394299
17glyoxylate metabolic process (GO:0046487)3.92289896
18negative regulation of fibrinolysis (GO:0051918)3.88463059
19protein carboxylation (GO:0018214)3.84518084
20peptidyl-glutamic acid carboxylation (GO:0017187)3.84518084
21valine metabolic process (GO:0006573)3.82887672
22basement membrane organization (GO:0071711)3.82498944
23* maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.77594794
24regulation of cholesterol homeostasis (GO:2000188)3.72730714
25intestinal cholesterol absorption (GO:0030299)3.70562909
26proline biosynthetic process (GO:0006561)3.64757427
27activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.60030873
28* protein retention in ER lumen (GO:0006621)3.57997180
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.57562144
30aromatic amino acid family catabolic process (GO:0009074)3.54877189
312-oxoglutarate metabolic process (GO:0006103)3.51511135
32COPII vesicle coating (GO:0048208)3.50783811
33positive regulation of nuclease activity (GO:0032075)3.46738467
34regulation of fatty acid beta-oxidation (GO:0031998)3.44631206
35skin morphogenesis (GO:0043589)3.43116866
36cellular modified amino acid catabolic process (GO:0042219)3.42321040
37positive regulation of fatty acid beta-oxidation (GO:0032000)3.42079193
38endothelial cell chemotaxis (GO:0035767)3.40722399
39tricarboxylic acid metabolic process (GO:0072350)3.40446948
40kynurenine metabolic process (GO:0070189)3.39406648
41homocysteine metabolic process (GO:0050667)3.36129859
42regulation of triglyceride catabolic process (GO:0010896)3.31557402
43heterochromatin organization (GO:0070828)3.30788144
44regulation of early endosome to late endosome transport (GO:2000641)3.30536901
45convergent extension (GO:0060026)3.29312314
46desmosome organization (GO:0002934)3.26420021
47regulation of mammary gland epithelial cell proliferation (GO:0033599)3.26191319
48cochlea morphogenesis (GO:0090103)3.26039471
49regulation of fibrinolysis (GO:0051917)3.24276962
50high-density lipoprotein particle remodeling (GO:0034375)3.24148579
51complement activation, alternative pathway (GO:0006957)3.23944882
52fatty acid beta-oxidation (GO:0006635)3.23479246
53positive regulation of triglyceride metabolic process (GO:0090208)3.23475071
54regulation of protein activation cascade (GO:2000257)3.22518153
55urea cycle (GO:0000050)3.21666864
56urea metabolic process (GO:0019627)3.21666864
57amino-acid betaine metabolic process (GO:0006577)3.19445813
58negative regulation of sterol transport (GO:0032372)3.16452464
59negative regulation of cholesterol transport (GO:0032375)3.16452464
60endoplasmic reticulum unfolded protein response (GO:0030968)3.14845414
61plasma lipoprotein particle clearance (GO:0034381)3.14026806
62negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.13724265
63bile acid biosynthetic process (GO:0006699)3.13324891
64positive regulation of triglyceride biosynthetic process (GO:0010867)3.13105163
65protein hydroxylation (GO:0018126)3.11354346
66regulation of complement activation (GO:0030449)3.10677674
67regulation of nuclease activity (GO:0032069)3.09949033
68Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.09524756
69low-density lipoprotein particle clearance (GO:0034383)3.07583612
70fatty acid oxidation (GO:0019395)3.04851903
71establishment of apical/basal cell polarity (GO:0035089)3.04805073
72exocrine pancreas development (GO:0031017)3.00807884
73cellular response to unfolded protein (GO:0034620)3.00652809
74aspartate family amino acid catabolic process (GO:0009068)3.00590339
75reverse cholesterol transport (GO:0043691)3.00147315
76positive regulation of fatty acid oxidation (GO:0046321)2.99582055
77intestinal absorption (GO:0050892)2.99516558
78adherens junction assembly (GO:0034333)2.96701160
79lipid oxidation (GO:0034440)2.96630293
80nitrogen cycle metabolic process (GO:0071941)2.96472669
81ethanol oxidation (GO:0006069)2.94851022
82maternal placenta development (GO:0001893)2.94361687
83regulation of establishment of planar polarity (GO:0090175)2.94189097
84serine family amino acid catabolic process (GO:0009071)2.92584147
85epithelial cell-cell adhesion (GO:0090136)2.92118991
86ER-nucleus signaling pathway (GO:0006984)2.91974346
87oxaloacetate metabolic process (GO:0006107)2.91407652
88fatty acid catabolic process (GO:0009062)2.90890888
89GDP-mannose metabolic process (GO:0019673)2.90798461
90regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.89952838
91epoxygenase P450 pathway (GO:0019373)2.89919647
92retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.89802793
93indole-containing compound catabolic process (GO:0042436)2.89683843
94indolalkylamine catabolic process (GO:0046218)2.89683843
95tryptophan catabolic process (GO:0006569)2.89683843
96hemidesmosome assembly (GO:0031581)2.89464926
97apoptotic cell clearance (GO:0043277)2.88556840
98regulation of fatty acid oxidation (GO:0046320)2.87505623
99regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.87409083
100triglyceride homeostasis (GO:0070328)2.87140593
101acylglycerol homeostasis (GO:0055090)2.87140593
102cell-cell junction maintenance (GO:0045217)2.87139232
103positive regulation of lipid catabolic process (GO:0050996)2.84775480
104regulation of plasminogen activation (GO:0010755)2.84173740
105glucose 6-phosphate metabolic process (GO:0051156)2.83396383
106pentose-phosphate shunt (GO:0006098)2.83018774
107cellular response to topologically incorrect protein (GO:0035967)2.82118792
108short-chain fatty acid metabolic process (GO:0046459)2.82028866
109paraxial mesoderm development (GO:0048339)2.81249365
110adhesion of symbiont to host (GO:0044406)2.79279412
111positive regulation of fatty acid biosynthetic process (GO:0045723)2.78493049
112cell-substrate junction assembly (GO:0007044)2.77851397
113proline metabolic process (GO:0006560)2.77013128
114tryptophan metabolic process (GO:0006568)2.76858101
115monocarboxylic acid catabolic process (GO:0072329)2.76709017
116transcytosis (GO:0045056)2.75837434
117endodermal cell differentiation (GO:0035987)2.74727449
118focal adhesion assembly (GO:0048041)2.74091623
119cell-substrate adherens junction assembly (GO:0007045)2.74091623
120branched-chain amino acid metabolic process (GO:0009081)2.73952869
121cellular amino acid catabolic process (GO:0009063)2.73223837
122alpha-amino acid catabolic process (GO:1901606)2.73191409
123negative regulation of chondrocyte differentiation (GO:0032331)2.73017995
124acetyl-CoA metabolic process (GO:0006084)2.72936376
125bile acid metabolic process (GO:0008206)2.72277355
126peptidyl-proline hydroxylation (GO:0019511)2.71993224
127lipoprotein metabolic process (GO:0042157)2.71938342
128positive regulation of triglyceride lipase activity (GO:0061365)2.70819931
129positive regulation of lipoprotein lipase activity (GO:0051006)2.70819931
130glycine metabolic process (GO:0006544)2.70311907
131macromolecular complex remodeling (GO:0034367)2.70302203
132plasma lipoprotein particle remodeling (GO:0034369)2.70302203
133endothelial cell morphogenesis (GO:0001886)2.69877854
134barbed-end actin filament capping (GO:0051016)2.68217466
135regulation of apoptotic process involved in morphogenesis (GO:1902337)2.62345153
136chondrocyte proliferation (GO:0035988)2.61172065
137G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.60702223
138semaphorin-plexin signaling pathway (GO:0071526)2.59606091
139collagen fibril organization (GO:0030199)2.57830347
140cell adhesion mediated by integrin (GO:0033627)2.57434996
141glucose catabolic process (GO:0006007)2.57228786
142embryonic skeletal joint morphogenesis (GO:0060272)2.55478634
143apoptotic process involved in morphogenesis (GO:0060561)2.55069505
144protein heterotrimerization (GO:0070208)2.49381324
145dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.48819361
146atrioventricular valve morphogenesis (GO:0003181)2.46203259
147negative regulation of cell size (GO:0045792)2.46120623
148regulation of extracellular matrix disassembly (GO:0010715)2.45544880
149endocardial cushion development (GO:0003197)2.44726851
150gap junction assembly (GO:0016264)2.44473537
151non-canonical Wnt signaling pathway (GO:0035567)2.43908621
152muscle cell migration (GO:0014812)2.42007939
153adhesion of symbiont to host cell (GO:0044650)2.41975036
154virion attachment to host cell (GO:0019062)2.41975036
155blood vessel endothelial cell migration (GO:0043534)2.40837965
156regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.39531455
157mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.39371630
158tooth mineralization (GO:0034505)2.38729675
159vesicle coating (GO:0006901)2.36906421
160positive regulation of blood vessel endothelial cell migration (GO:0043536)2.36176340
161branching involved in mammary gland duct morphogenesis (GO:0060444)2.34931161
162embryo implantation (GO:0007566)2.34823703
163regulation of glucose import in response to insulin stimulus (GO:2001273)2.32234636
164nucleotide-sugar biosynthetic process (GO:0009226)2.31740495
165regulation of cardioblast differentiation (GO:0051890)2.31680604
166NADPH regeneration (GO:0006740)2.31316273
167branching involved in salivary gland morphogenesis (GO:0060445)2.31117333
168vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.30446005
169retina vasculature morphogenesis in camera-type eye (GO:0061299)2.30328016
170neural tube development (GO:0021915)2.27881151
171notochord development (GO:0030903)2.26658541
172regulation of cholesterol biosynthetic process (GO:0045540)2.26547092
173cytoskeletal anchoring at plasma membrane (GO:0007016)2.25416147
174establishment or maintenance of monopolar cell polarity (GO:0061339)2.24619819
175establishment of monopolar cell polarity (GO:0061162)2.24619819
176ribosomal small subunit biogenesis (GO:0042274)2.24449203

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.54281280
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.01773230
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.66538636
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.32150487
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.58562895
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.91838471
7CLOCK_20551151_ChIP-Seq_293T_Human2.83432183
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.83030945
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.64183360
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.48562499
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.30470560
12* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.25470038
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.19765329
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.18301178
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.16088776
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.13399349
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.89647464
18LXR_22292898_ChIP-Seq_THP-1_Human1.88024822
19ZNF263_19887448_ChIP-Seq_K562_Human1.87503922
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.78629762
21TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75198436
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.73548878
23* ELK3_25401928_ChIP-Seq_HUVEC_Human1.73349777
24TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73111119
25CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.70890528
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.68368863
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.67524267
28RACK7_27058665_Chip-Seq_MCF-7_Human1.67102372
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.65695226
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65251386
31DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.64997371
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.63748545
33HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.62684007
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.60253967
35MYC_22102868_ChIP-Seq_BL_Human1.60123159
36ATF3_27146783_Chip-Seq_COLON_Human1.54867660
37SOX2_27498859_Chip-Seq_STOMACH_Mouse1.54756390
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.54193558
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52182636
40KDM2B_26808549_Chip-Seq_K562_Human1.51452005
41SRY_22984422_ChIP-ChIP_TESTIS_Rat1.50434919
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.50028735
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.48582291
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.47433260
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47379741
46RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.45206150
47TP53_22127205_ChIP-Seq_IMR90_Human1.39654857
48KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39149067
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38180873
50CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.37968359
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.34571371
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.34560825
53VDR_21846776_ChIP-Seq_THP-1_Human1.32866525
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.32050114
55EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31194756
56SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.29318005
57XRN2_22483619_ChIP-Seq_HELA_Human1.29257399
58* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28361494
59GATA1_22025678_ChIP-Seq_K562_Human1.28086048
60SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28047959
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28039158
62TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.27432483
63FOXM1_23109430_ChIP-Seq_U2OS_Human1.25705042
64AR_21909140_ChIP-Seq_LNCAP_Human1.23641390
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23478987
66ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.20394502
67TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18357711
68GATA6_25053715_ChIP-Seq_YYC3_Human1.18351388
69TBX20_22328084_ChIP-Seq_HEART_Mouse1.18336273
70TBX20_22080862_ChIP-Seq_HEART_Mouse1.18336273
71HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17944972
72P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17084665
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17045321
74GATA4_25053715_ChIP-Seq_YYC3_Human1.16258560
75* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16116884
76CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16055335
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15839300
78TP53_20018659_ChIP-ChIP_R1E_Mouse1.15478089
79NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15043515
80TCF7_22412390_ChIP-Seq_EML_Mouse1.14980684
81SMC4_20622854_ChIP-Seq_HELA_Human1.14274609
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.13595144
83KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13583741
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13345585
85CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13237648
86NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12653326
87UBF1/2_26484160_Chip-Seq_HMECs_Human1.12372813
88* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12064032
89PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11452516
90KDM2B_26808549_Chip-Seq_DND41_Human1.09460780
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09007385
92SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.08708904
93RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08486071
94KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08257092
95FOXO3_23340844_ChIP-Seq_DLD1_Human1.06806169
96CTCF_27219007_Chip-Seq_Bcells_Human1.06632484
97STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.06384128
98FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.06368727
99E2F7_22180533_ChIP-Seq_HELA_Human1.06246948
100BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04521178
101OCT4_18692474_ChIP-Seq_MEFs_Mouse1.04235945
102FOXA2_19822575_ChIP-Seq_HepG2_Human1.04136348
103NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03101995
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02622019
105E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01967615
106CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01638740
107UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01406969
108ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00898686
109* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99869751
110RARA_24833708_ChIP-Seq_LIVER_Mouse0.99853580
111* CREB1_26743006_Chip-Seq_LNCaP_Human0.99253713
112MYC_19030024_ChIP-ChIP_MESCs_Mouse0.98691183
113* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98625804
114KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97401740
115NANOG_21062744_ChIP-ChIP_HESCs_Human0.97099378
116THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95626417
117NCOR1_26117541_ChIP-Seq_K562_Human0.93416717
118POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93235352
119P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91258122
120P68_20966046_ChIP-Seq_HELA_Human0.90682100
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90349513
122PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90256461
123* CTCF_21964334_Chip-Seq_Bcells_Human0.87887079
124SOX2_20726797_ChIP-Seq_SW620_Human0.87122107
125MAF_26560356_Chip-Seq_TH1_Human0.87046092
126CDX2_20551321_ChIP-Seq_CACO-2_Human0.86936308
127ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86622240
128ZFP281_18757296_ChIP-ChIP_E14_Mouse0.86306108
129ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.86183053
130GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86136045
131RUNX1_27514584_Chip-Seq_MCF-7_Human0.85029416
132ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84792534
133TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84722933
134SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.84537166
135KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.84221977
136SA1_27219007_Chip-Seq_ERYTHROID_Human0.84103746
137HNF4A_19822575_ChIP-Seq_HepG2_Human0.82706069
138SALL4_18804426_ChIP-ChIP_XEN_Mouse0.81789594
139TET1_21451524_ChIP-Seq_MESCs_Mouse0.81659789
140GATA1_19941826_ChIP-Seq_K562_Human0.81526254
141NFIB_24661679_ChIP-Seq_LUNG_Mouse0.81371130
142ELF1_20517297_ChIP-Seq_JURKAT_Human0.80256605
143BCOR_27268052_Chip-Seq_Bcells_Human0.79744538
144FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.79696401
145UTX_26944678_Chip-Seq_JUKART_Human0.79410954

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.54753614
2MP0005360_urolithiasis4.31409156
3MP0005365_abnormal_bile_salt3.72969803
4MP0003705_abnormal_hypodermis_morpholog3.64508778
5MP0005085_abnormal_gallbladder_physiolo3.32229850
6MP0010030_abnormal_orbit_morphology3.16864173
7MP0008438_abnormal_cutaneous_collagen3.12483691
8MP0009840_abnormal_foam_cell2.91310073
9MP0004858_abnormal_nervous_system2.72067124
10MP0003252_abnormal_bile_duct2.60147675
11MP0005083_abnormal_biliary_tract2.56195502
12MP0001666_abnormal_nutrient_absorption2.47205922
13MP0008875_abnormal_xenobiotic_pharmacok2.40667352
14MP0003806_abnormal_nucleotide_metabolis2.29189980
15MP0000678_abnormal_parathyroid_gland2.24365290
16MP0010329_abnormal_lipoprotein_level2.16118620
17MP0005623_abnormal_meninges_morphology2.01027192
18MP0002249_abnormal_larynx_morphology1.96581116
19MP0005275_abnormal_skin_tensile1.94952640
20MP0003300_gastrointestinal_ulcer1.93366046
21MP0003191_abnormal_cellular_cholesterol1.90721208
22MP0005451_abnormal_body_composition1.89276286
23MP0003195_calcinosis1.86071818
24MP0003942_abnormal_urinary_system1.84983454
25MP0006054_spinal_hemorrhage1.81699418
26MP0005332_abnormal_amino_acid1.79606449
27MP0000566_synostosis1.78278381
28MP0000537_abnormal_urethra_morphology1.69018909
29MP0005220_abnormal_exocrine_pancreas1.65268692
30MP0000534_abnormal_ureter_morphology1.62187870
31MP0003566_abnormal_cell_adhesion1.57374411
32MP0009643_abnormal_urine_homeostasis1.57273528
33MP0002837_dystrophic_cardiac_calcinosis1.56492701
34MP0005409_darkened_coat_color1.56164910
35MP0000609_abnormal_liver_physiology1.55238821
36MP0003941_abnormal_skin_development1.54016854
37MP0002877_abnormal_melanocyte_morpholog1.51777481
38MP0004233_abnormal_muscle_weight1.50594082
39MP0002138_abnormal_hepatobiliary_system1.47461575
40MP0010352_gastrointestinal_tract_polyps1.44798196
41MP0000762_abnormal_tongue_morphology1.44556638
42MP0005319_abnormal_enzyme/_coenzyme1.44204170
43MP0002118_abnormal_lipid_homeostasis1.43161146
44MP0010368_abnormal_lymphatic_system1.42210054
45MP0003385_abnormal_body_wall1.40527998
46MP0003279_aneurysm1.35125911
47MP0005508_abnormal_skeleton_morphology1.34427792
48MP0010234_abnormal_vibrissa_follicle1.33958659
49MP0004272_abnormal_basement_membrane1.30889549
50MP0002697_abnormal_eye_size1.30314848
51MP0009384_cardiac_valve_regurgitation1.30067377
52MP0004264_abnormal_extraembryonic_tissu1.29254658
53MP0005058_abnormal_lysosome_morphology1.27539333
54MP0003283_abnormal_digestive_organ1.24161542
55MP0000049_abnormal_middle_ear1.22823317
56MP0002796_impaired_skin_barrier1.20312332
57MP0003115_abnormal_respiratory_system1.20098826
58MP0005023_abnormal_wound_healing1.19643518
59MP0004130_abnormal_muscle_cell1.18984160
60MP0005501_abnormal_skin_physiology1.18961463
61MP0003123_paternal_imprinting1.17957604
62MP0004019_abnormal_vitamin_homeostasis1.14803181
63MP0000428_abnormal_craniofacial_morphol1.11310041
64MP0005503_abnormal_tendon_morphology1.11157297
65MP0000462_abnormal_digestive_system1.09721403
66MP0005666_abnormal_adipose_tissue1.09447425
67MP0004185_abnormal_adipocyte_glucose1.08420537
68MP0005670_abnormal_white_adipose1.08215047
69MP0009250_abnormal_appendicular_skeleto1.08149533
70MP0003868_abnormal_feces_composition1.08095256
71MP0008932_abnormal_embryonic_tissue1.07753281
72MP0003315_abnormal_perineum_morphology1.07679521
73MP0009672_abnormal_birth_weight1.06140099
74MP0000598_abnormal_liver_morphology1.05456626
75MP0001756_abnormal_urination1.05184341
76MP0003091_abnormal_cell_migration1.04611494
77MP0002896_abnormal_bone_mineralization1.04418664
78MP0000681_abnormal_thyroid_gland1.02762858
79MP0001958_emphysema1.01804971
80MP0001730_embryonic_growth_arrest0.99865649
81MP0002932_abnormal_joint_morphology0.99749197
82MP0001944_abnormal_pancreas_morphology0.99182579
83MP0009053_abnormal_anal_canal0.97740362
84MP0004084_abnormal_cardiac_muscle0.97454184
85MP0001348_abnormal_lacrimal_gland0.95832297
86MP0005375_adipose_tissue_phenotype0.95392855
87MP0002060_abnormal_skin_morphology0.92319483
88MP0002116_abnormal_craniofacial_bone0.91746597
89MP0000013_abnormal_adipose_tissue0.91674994
90MP0003453_abnormal_keratinocyte_physiol0.91492192
91MP0003186_abnormal_redox_activity0.91199194
92MP0005584_abnormal_enzyme/coenzyme_acti0.91165074
93MP0002085_abnormal_embryonic_tissue0.91080156
94MP0001299_abnormal_eye_distance/0.90441019
95MP0002078_abnormal_glucose_homeostasis0.90225965
96MP0005197_abnormal_uvea_morphology0.89576908
97MP0000467_abnormal_esophagus_morphology0.89459103
98MP0002092_abnormal_eye_morphology0.88949438
99MP0003755_abnormal_palate_morphology0.88548159
100MP0000003_abnormal_adipose_tissue0.88174893
101MP0000432_abnormal_head_morphology0.86693297
102MP0001915_intracranial_hemorrhage0.85651267
103MP0002111_abnormal_tail_morphology0.85267546
104MP0005330_cardiomyopathy0.84394003
105MP0000750_abnormal_muscle_regeneration0.84186218
106MP0009379_abnormal_foot_pigmentation0.83228194
107MP0005636_abnormal_mineral_homeostasis0.83012406
108MP0002269_muscular_atrophy0.82978772
109MP0000163_abnormal_cartilage_morphology0.81873882
110MP0005084_abnormal_gallbladder_morpholo0.81734632
111MP0008260_abnormal_autophagy0.81491659
112MP0008961_abnormal_basal_metabolism0.81329151
113MP0001849_ear_inflammation0.80639031
114MP0003935_abnormal_craniofacial_develop0.78805956
115MP0004087_abnormal_muscle_fiber0.78769114
116MP0005076_abnormal_cell_differentiation0.78343957
117MP0002114_abnormal_axial_skeleton0.77580659
118MP0003656_abnormal_erythrocyte_physiolo0.77431876
119MP0003937_abnormal_limbs/digits/tail_de0.77273645
120MP0003984_embryonic_growth_retardation0.76784656
121MP0001614_abnormal_blood_vessel0.76558606
122MP0004043_abnormal_pH_regulation0.75928846
123MP0010630_abnormal_cardiac_muscle0.75689596
124MP0001672_abnormal_embryogenesis/_devel0.75505783
125MP0005380_embryogenesis_phenotype0.75505783
126MP0004957_abnormal_blastocyst_morpholog0.74894590
127MP0000858_altered_metastatic_potential0.74129384
128MP0005257_abnormal_intraocular_pressure0.72744810
129MP0002080_prenatal_lethality0.72733919
130MP0002295_abnormal_pulmonary_circulatio0.71947200
131MP0001661_extended_life_span0.71239753
132MP0002938_white_spotting0.71204399
133MP0002108_abnormal_muscle_morphology0.71157986
134MP0002113_abnormal_skeleton_development0.70843997
135MP0002086_abnormal_extraembryonic_tissu0.70465702
136MP0002971_abnormal_brown_adipose0.70425147
137MP0002136_abnormal_kidney_physiology0.68840379
138MP0005334_abnormal_fat_pad0.68091974
139MP0002909_abnormal_adrenal_gland0.66865846
140MP0009642_abnormal_blood_homeostasis0.66827017
141MP0009780_abnormal_chondrocyte_physiolo0.66462730
142MP0002168_other_aberrant_phenotype0.66360892
143MP0001765_abnormal_ion_homeostasis0.65853584
144MP0006036_abnormal_mitochondrial_physio0.65101307
145MP0002693_abnormal_pancreas_physiology0.64556417
146MP0001243_abnormal_dermal_layer0.64430348
147MP0001533_abnormal_skeleton_physiology0.64010881
148MP0003959_abnormal_lean_body0.60624757
149MP0000747_muscle_weakness0.60368624
150MP0008775_abnormal_heart_ventricle0.59669863
151MP0000767_abnormal_smooth_muscle0.59508213
152MP0000751_myopathy0.59495189
153MP0000343_altered_response_to0.59401420
154MP0002254_reproductive_system_inflammat0.59392676
155MP0008469_abnormal_protein_level0.59053959
156MP0002135_abnormal_kidney_morphology0.58899138
157MP0005385_cardiovascular_system_phenoty0.58225121
158MP0001544_abnormal_cardiovascular_syste0.58225121
159MP0006138_congestive_heart_failure0.57927588
160MP0000733_abnormal_muscle_development0.57174369
161MP0002089_abnormal_postnatal_growth/wei0.56868332
162MP0003436_decreased_susceptibility_to0.56484045

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.31811883
2Protrusio acetabuli (HP:0003179)4.12531005
3Hypoglycemic coma (HP:0001325)4.07214997
4Abnormality of aromatic amino acid family metabolism (HP:0004338)3.98667381
5Xanthomatosis (HP:0000991)3.86606023
6Ketosis (HP:0001946)3.49740813
7Abnormality of monocarboxylic acid metabolism (HP:0010996)3.49048282
8Intrahepatic cholestasis (HP:0001406)3.47228844
9Ketoacidosis (HP:0001993)3.42860794
10Premature rupture of membranes (HP:0001788)3.17578113
11Abnormality of the intrinsic pathway (HP:0010989)3.10847578
12Abnormality of dentin (HP:0010299)3.02321176
13Abnormality of the common coagulation pathway (HP:0010990)3.00714972
14Hyperammonemia (HP:0001987)2.94090439
15Abnormality of glutamine family amino acid metabolism (HP:0010902)2.88780976
16Right ventricular cardiomyopathy (HP:0011663)2.88598489
17Complement deficiency (HP:0004431)2.88400408
18Bladder diverticulum (HP:0000015)2.87070575
19Hyperacusis (HP:0010780)2.82001414
20Late onset (HP:0003584)2.79635378
21Peritonitis (HP:0002586)2.77219437
22Hypobetalipoproteinemia (HP:0003563)2.76846334
23Hypoglycemic seizures (HP:0002173)2.74599177
24Hyperglycinuria (HP:0003108)2.68612488
25Hyperinsulinemic hypoglycemia (HP:0000825)2.65731829
26Ulnar bowing (HP:0003031)2.64312717
27Cerebral aneurysm (HP:0004944)2.63040935
28Gout (HP:0001997)2.62229065
29Abnormality of fatty-acid metabolism (HP:0004359)2.61672093
30Achilles tendon contracture (HP:0001771)2.59901205
31Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.54018554
32Disproportionate tall stature (HP:0001519)2.53447046
33Hyperlipoproteinemia (HP:0010980)2.52586010
34Abnormal cartilage morphology (HP:0002763)2.52556951
35Spinal rigidity (HP:0003306)2.52087507
36Biconcave vertebral bodies (HP:0004586)2.46331308
37Hypolipoproteinemia (HP:0010981)2.45819301
38Hypoalphalipoproteinemia (HP:0003233)2.45781848
39Neonatal short-limb short stature (HP:0008921)2.42813117
40Abnormality of glycine metabolism (HP:0010895)2.42436508
41Abnormality of serine family amino acid metabolism (HP:0010894)2.42436508
42Abnormality of the acetabulum (HP:0003170)2.39504173
43Abnormality of purine metabolism (HP:0004352)2.38663318
44Myoglobinuria (HP:0002913)2.36253075
45Vascular tortuosity (HP:0004948)2.34477150
46Cervical subluxation (HP:0003308)2.34260583
47Soft skin (HP:0000977)2.33212841
48Wormian bones (HP:0002645)2.32290880
49Mucopolysacchariduria (HP:0008155)2.31574323
50Urinary glycosaminoglycan excretion (HP:0003541)2.31574323
51Aneurysm (HP:0002617)2.30499109
52Ankle contracture (HP:0006466)2.28485024
53Renal duplication (HP:0000075)2.27472025
54Natal tooth (HP:0000695)2.27376409
55Generalized aminoaciduria (HP:0002909)2.26525329
56Skin nodule (HP:0200036)2.26362393
57Hyperglycemia (HP:0003074)2.25375121
58Myocardial infarction (HP:0001658)2.25209342
59Fat malabsorption (HP:0002630)2.24166207
60Asymmetric septal hypertrophy (HP:0001670)2.24091980
61Broad metatarsal (HP:0001783)2.23950486
62Abnormality of complement system (HP:0005339)2.23472728
63Abnormality of sulfur amino acid metabolism (HP:0004339)2.23164614
64Short nail (HP:0001799)2.23134204
65Polycythemia (HP:0001901)2.22989871
66Prolonged partial thromboplastin time (HP:0003645)2.21206700
67Back pain (HP:0003418)2.20437973
68Aortic aneurysm (HP:0004942)2.19828391
69Arterial tortuosity (HP:0005116)2.19528466
70Hydroxyprolinuria (HP:0003080)2.19498503
71Abnormality of proline metabolism (HP:0010907)2.19498503
72Abnormality of carpal bone ossification (HP:0006257)2.18484942
73Lymphangioma (HP:0100764)2.18355824
74Aortic dissection (HP:0002647)2.17927120
75Hyperglycinemia (HP:0002154)2.17247084
76Genu recurvatum (HP:0002816)2.17233329
77Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.14855456
78Shallow orbits (HP:0000586)2.13770457
79Mildly elevated creatine phosphokinase (HP:0008180)2.12587694
80Abnormal delivery (HP:0001787)2.11101270
81Long palpebral fissure (HP:0000637)2.10530992
82Abnormality of mucopolysaccharide metabolism (HP:0011020)2.06439417
83Abnormality of polysaccharide metabolism (HP:0011012)2.06439417
84Abnormality of glycosaminoglycan metabolism (HP:0004371)2.06439417
85Dysostosis multiplex (HP:0000943)2.04846376
86Hyperextensible skin (HP:0000974)2.03857047
87Abnormal ossification of hand bones (HP:0005921)2.02552715
88Epidermoid cyst (HP:0200040)2.02417869
89Trismus (HP:0000211)2.02370834
90Advanced eruption of teeth (HP:0006288)2.02367271
91Mitral valve prolapse (HP:0001634)2.02275924
92Premature skin wrinkling (HP:0100678)2.01739696
93Elbow flexion contracture (HP:0002987)2.01703576
94Blue sclerae (HP:0000592)2.01164428
95Asymmetry of the thorax (HP:0001555)2.00403657
96Dicarboxylic aciduria (HP:0003215)1.99635114
97Abnormality of dicarboxylic acid metabolism (HP:0010995)1.99635114
98Mitral regurgitation (HP:0001653)1.99549085
99Abnormality of the Achilles tendon (HP:0005109)1.99398526
100Abnormality of the distal phalanges of the toes (HP:0010182)1.98269765
101Thin bony cortex (HP:0002753)1.97630266
102Ectopia lentis (HP:0001083)1.96965077
103Abnormality of nucleobase metabolism (HP:0010932)1.96700097
104Hepatocellular carcinoma (HP:0001402)1.96632397
105Joint laxity (HP:0001388)1.96445031
106Multiple enchondromatosis (HP:0005701)1.95418932
107Esophageal varix (HP:0002040)1.95274139
108Spastic diplegia (HP:0001264)1.94848104
109Coxa vara (HP:0002812)1.94607105
110Symptomatic seizures (HP:0011145)1.93737796
111Atrophic scars (HP:0001075)1.92077012
112Beaking of vertebral bodies (HP:0004568)1.91577914
113Increased connective tissue (HP:0009025)1.90128543
114Malnutrition (HP:0004395)1.89924821
115Insulin resistance (HP:0000855)1.89539505
116Protuberant abdomen (HP:0001538)1.89535385
117Long toe (HP:0010511)1.89517167
118Abnormality of endocrine pancreas physiology (HP:0012093)1.89175240
119Abnormality of the pancreatic islet cells (HP:0006476)1.89175240
120Abnormality of the distal phalanx of the thumb (HP:0009617)1.87434741
121Broad face (HP:0000283)1.86454844
122Flat acetabular roof (HP:0003180)1.86267757
123Insomnia (HP:0100785)1.85896284
124Systemic lupus erythematosus (HP:0002725)1.83051993
125Coronal craniosynostosis (HP:0004440)1.82118582
126Joint hemorrhage (HP:0005261)1.81990935
127Hypercholesterolemia (HP:0003124)1.81979591
128Hand muscle atrophy (HP:0009130)1.81817512
129Hyperbilirubinemia (HP:0002904)1.81452497
130Nonimmune hydrops fetalis (HP:0001790)1.81329584
131Abdominal distention (HP:0003270)1.80934774
132Turricephaly (HP:0000262)1.80835932
133Pterygium (HP:0001059)1.80570338
134Fragile skin (HP:0001030)1.78247630
135Inguinal hernia (HP:0000023)1.77592393
136Cupped ribs (HP:0000887)1.77232510
137Arnold-Chiari malformation (HP:0002308)1.77157649
138Breech presentation (HP:0001623)1.76063823
139Abnormality of the phalanges of the hallux (HP:0010057)1.76019901
140Distal upper limb amyotrophy (HP:0007149)1.75984216
141Upper limb amyotrophy (HP:0009129)1.75984216
142Hyperparathyroidism (HP:0000843)1.75649685
143Generalized amyotrophy (HP:0003700)1.75267022
144Cardiovascular calcification (HP:0011915)1.74223363
145Follicular hyperkeratosis (HP:0007502)1.72836420
146Vertebral compression fractures (HP:0002953)1.72713008
147Congenital glaucoma (HP:0001087)1.70878795
148Abnormality of the umbilical cord (HP:0010881)1.69976197
149Venous abnormality (HP:0002624)1.68713374
150Midface retrusion (HP:0011800)1.67593801
151Bronchomalacia (HP:0002780)1.67224086
152Absent epiphyses (HP:0010577)1.65822775
153Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.65822775
154Abnormality of the aortic arch (HP:0012303)1.65051553
155J-shaped sella turcica (HP:0002680)1.64887889
156Delayed cranial suture closure (HP:0000270)1.64465626
157Flattened epiphyses (HP:0003071)1.64047029
158Nuclear cataract (HP:0100018)1.63358358
159Hypoplasia of the capital femoral epiphysis (HP:0003090)1.62537708
160Thin ribs (HP:0000883)1.62077491
161Neonatal death (HP:0003811)1.61359207
162Platyspondyly (HP:0000926)1.61244154
163Hypoventilation (HP:0002791)1.60676171
164Abnormal gallbladder physiology (HP:0012438)1.59862445
165Cholecystitis (HP:0001082)1.59862445
166Deviation of the hallux (HP:0010051)1.59449743
167Selective tooth agenesis (HP:0001592)1.59207672
168Abnormality of the thoracic spine (HP:0100711)1.59132253
169Atelectasis (HP:0100750)1.57356136
170Venous insufficiency (HP:0005293)1.57229754
171Joint stiffness (HP:0001387)1.56775541

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.26777008
2TRIB35.23646616
3PKN24.02205947
4BCKDK3.69634635
5SMG13.40144202
6SIK12.59650355
7CDK122.51775839
8IRAK32.26510530
9TTN2.13260748
10PTK62.08985025
11PDGFRA1.98065376
12FGFR41.97833767
13EEF2K1.95569617
14VRK21.94139825
15FLT31.93241318
16MAP3K101.91143592
17RIPK11.84105103
18TAOK31.81161262
19LATS11.80782719
20LRRK21.57112843
21ARAF1.56958615
22DDR21.48309543
23NTRK11.42468816
24LIMK11.38425150
25PRPF4B1.36804025
26PTK21.29190889
27SCYL21.28588420
28TGFBR21.24603605
29INSRR1.24509791
30MAPKAPK31.22841149
31EPHB11.18225526
32BRAF1.17215547
33NME21.16618683
34CDK71.12208155
35PAK41.11949799
36PIK3CG1.09780542
37MAP3K31.09152573
38MAP2K31.07760284
39LMTK21.06068981
40KDR1.04332283
41MAP2K21.02067484
42TAOK11.01781218
43EPHA30.98622405
44TESK10.98430414
45LATS20.97121060
46MAP3K110.96638894
47PRKD20.95746487
48PAK20.93842132
49MST1R0.92453932
50CDC42BPA0.92420295
51EPHB20.92004287
52EPHA20.91903287
53MET0.88954361
54TBK10.88490115
55BMX0.88163581
56NEK10.88032093
57NEK20.87735087
58ILK0.86637748
59TYK20.85969477
60MTOR0.85845831
61PASK0.85055937
62DYRK1B0.82746132
63DMPK0.81847615
64ZAP700.80448081
65FER0.79294206
66NEK90.78629198
67MAP3K20.77987320
68RPS6KA20.77338573
69MYLK0.77235195
70RET0.75825718
71MAP3K10.75793268
72TYRO30.73879329
73KSR20.73739760
74CDK60.73582845
75FRK0.73523865
76JAK20.72967547
77ERBB40.69696537
78MAP3K80.68743332
79CDK80.68626757
80MAPK110.67760234
81TGFBR10.67283077
82BRSK10.67007997
83BUB10.66763062
84MAP3K90.65032616
85MAP3K70.64396872
86TIE10.63574001
87CAMK1D0.63433532
88MAP2K10.61484033
89JAK30.61067953
90RPS6KB20.60599216
91RPS6KA40.59221676
92ICK0.59180413
93PRKG20.58325228
94CAMK1G0.57793347
95PAK30.57423271
96WNK40.57137280
97HIPK20.56677386
98MAPK150.56110260
99STK380.55817686
100STK100.55704899
101PRKD30.54404614
102MOS0.54245846
103PRKD10.53885558
104JAK10.53463226
105PDGFRB0.52427941
106TTK0.51528494
107TAF10.51053308
108TESK20.50450772
109ABL20.50393750
110CDK90.50325652
111PIM20.49178415
112RPS6KL10.48985537
113RPS6KC10.48985537
114CHEK20.48135851
115CDK11A0.48110558
116MARK20.47309003
117AURKA0.47281648
118AKT20.46508367
119STK30.45818028
120PDK30.45604272
121PDK40.45604272
122CDK150.44826347
123CDK40.42931426
124ERBB20.41277879
125PAK10.40279724
126EIF2AK10.40181852
127CDK180.39675243
128TAOK20.39221415
129DAPK30.39117748
130STK38L0.38552524
131GSK3A0.36358791
132MAPKAPK20.35872714
133FGFR10.34915833
134STK40.34707749
135MELK0.34461290
136CSK0.34248627
137PRKAA20.34101839
138NME10.34060779
139PIK3CA0.33060904
140PDPK10.32997064
141FGFR30.32592843
142CDK140.32498113

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.97500963
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.92995380
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.79248491
4Nitrogen metabolism_Homo sapiens_hsa009102.74521202
5Fatty acid degradation_Homo sapiens_hsa000712.70124918
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.54627999
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.43049781
8Tryptophan metabolism_Homo sapiens_hsa003802.38113525
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.37337196
10Arginine biosynthesis_Homo sapiens_hsa002202.29178801
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.26948568
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.10514564
13Fat digestion and absorption_Homo sapiens_hsa049751.95732047
14Propanoate metabolism_Homo sapiens_hsa006401.95282452
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.92078582
16Complement and coagulation cascades_Homo sapiens_hsa046101.82575747
17Fatty acid metabolism_Homo sapiens_hsa012121.82463764
18PPAR signaling pathway_Homo sapiens_hsa033201.77936351
19Caffeine metabolism_Homo sapiens_hsa002321.77225723
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.72590523
21Sulfur metabolism_Homo sapiens_hsa009201.71667136
22Folate biosynthesis_Homo sapiens_hsa007901.70948480
23Selenocompound metabolism_Homo sapiens_hsa004501.70833302
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.64015329
25Notch signaling pathway_Homo sapiens_hsa043301.57891839
26Starch and sucrose metabolism_Homo sapiens_hsa005001.57208460
27Butanoate metabolism_Homo sapiens_hsa006501.56906290
28Carbon metabolism_Homo sapiens_hsa012001.54689384
29Peroxisome_Homo sapiens_hsa041461.52212485
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.51980505
31Basal cell carcinoma_Homo sapiens_hsa052171.51479774
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.46009538
33Pyruvate metabolism_Homo sapiens_hsa006201.41827630
34Biosynthesis of amino acids_Homo sapiens_hsa012301.33861601
35beta-Alanine metabolism_Homo sapiens_hsa004101.29852426
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.27655618
37Bile secretion_Homo sapiens_hsa049761.27576227
38Sulfur relay system_Homo sapiens_hsa041221.23855060
39Histidine metabolism_Homo sapiens_hsa003401.23000564
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20876402
41Hippo signaling pathway_Homo sapiens_hsa043901.15896901
42Chemical carcinogenesis_Homo sapiens_hsa052041.15409106
43Protein digestion and absorption_Homo sapiens_hsa049741.13056653
44Ribosome_Homo sapiens_hsa030101.09534499
45Galactose metabolism_Homo sapiens_hsa000521.08206065
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07804207
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05924360
48Phenylalanine metabolism_Homo sapiens_hsa003601.05698742
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05667998
50* Vibrio cholerae infection_Homo sapiens_hsa051101.03669014
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03490062
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03264400
53Arginine and proline metabolism_Homo sapiens_hsa003301.03160586
54Staphylococcus aureus infection_Homo sapiens_hsa051501.02980146
55Steroid biosynthesis_Homo sapiens_hsa001001.02416176
56Cyanoamino acid metabolism_Homo sapiens_hsa004601.00878901
57Lysine degradation_Homo sapiens_hsa003101.00187503
58Insulin resistance_Homo sapiens_hsa049310.97997402
59Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97002582
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96972143
61Vitamin B6 metabolism_Homo sapiens_hsa007500.92848458
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91028751
63Hedgehog signaling pathway_Homo sapiens_hsa043400.89117508
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.88845512
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.87777667
66MicroRNAs in cancer_Homo sapiens_hsa052060.87332769
67Bladder cancer_Homo sapiens_hsa052190.83183735
68Sphingolipid metabolism_Homo sapiens_hsa006000.82791341
69Pentose phosphate pathway_Homo sapiens_hsa000300.82777796
70Base excision repair_Homo sapiens_hsa034100.81791831
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81011330
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.77907687
73Tight junction_Homo sapiens_hsa045300.77523021
74Glycerolipid metabolism_Homo sapiens_hsa005610.77019579
75DNA replication_Homo sapiens_hsa030300.76966773
76Glutathione metabolism_Homo sapiens_hsa004800.75818617
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75719261
78ABC transporters_Homo sapiens_hsa020100.75305752
79Tyrosine metabolism_Homo sapiens_hsa003500.74611828
80Pancreatic cancer_Homo sapiens_hsa052120.73708953
81Endometrial cancer_Homo sapiens_hsa052130.73190989
82Retinol metabolism_Homo sapiens_hsa008300.73186813
83N-Glycan biosynthesis_Homo sapiens_hsa005100.72517613
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70444724
85ECM-receptor interaction_Homo sapiens_hsa045120.69089063
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.68690026
87Prostate cancer_Homo sapiens_hsa052150.68259462
88Thyroid hormone synthesis_Homo sapiens_hsa049180.68027376
89Other glycan degradation_Homo sapiens_hsa005110.67526248
90Protein export_Homo sapiens_hsa030600.66922516
91Vitamin digestion and absorption_Homo sapiens_hsa049770.65438121
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65315930
93Lysosome_Homo sapiens_hsa041420.65259921
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65066353
95Melanoma_Homo sapiens_hsa052180.64822014
96VEGF signaling pathway_Homo sapiens_hsa043700.64678137
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64657983
98Non-small cell lung cancer_Homo sapiens_hsa052230.63692656
99Wnt signaling pathway_Homo sapiens_hsa043100.61964117
100Melanogenesis_Homo sapiens_hsa049160.59891493
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59470263
102Fructose and mannose metabolism_Homo sapiens_hsa000510.59115016
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57937395
104Pyrimidine metabolism_Homo sapiens_hsa002400.57870600
105Renin-angiotensin system_Homo sapiens_hsa046140.56141187
106Axon guidance_Homo sapiens_hsa043600.55901750
107Focal adhesion_Homo sapiens_hsa045100.54658802
108TGF-beta signaling pathway_Homo sapiens_hsa043500.53670300
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53284005
110Pathways in cancer_Homo sapiens_hsa052000.50864225
111AMPK signaling pathway_Homo sapiens_hsa041520.50589389
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50585624
113Glioma_Homo sapiens_hsa052140.50142006
114Acute myeloid leukemia_Homo sapiens_hsa052210.49992895
115Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48486286
116Amoebiasis_Homo sapiens_hsa051460.47069232
117Prion diseases_Homo sapiens_hsa050200.44865961
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.44288034
119ErbB signaling pathway_Homo sapiens_hsa040120.43970998
120One carbon pool by folate_Homo sapiens_hsa006700.41482699
121Insulin signaling pathway_Homo sapiens_hsa049100.38906074
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38476258
123Proteoglycans in cancer_Homo sapiens_hsa052050.37765486
124Chronic myeloid leukemia_Homo sapiens_hsa052200.36654259
125Fatty acid elongation_Homo sapiens_hsa000620.36453591
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35306147
127Adherens junction_Homo sapiens_hsa045200.35201430
128Glucagon signaling pathway_Homo sapiens_hsa049220.34955863
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33666776
130Small cell lung cancer_Homo sapiens_hsa052220.33408670
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33232917
132Pancreatic secretion_Homo sapiens_hsa049720.29496857
133Thyroid cancer_Homo sapiens_hsa052160.29019293
134Metabolic pathways_Homo sapiens_hsa011000.24522906
135Fatty acid biosynthesis_Homo sapiens_hsa000610.23472657
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22695272
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21609944
138mTOR signaling pathway_Homo sapiens_hsa041500.19569180
139AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.19351765

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