KDELR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)8.72803845
2COPI coating of Golgi vesicle (GO:0048205)8.72803845
3signal peptide processing (GO:0006465)6.68961781
4COPII vesicle coating (GO:0048208)5.82105274
5* maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.82094910
6* protein retention in ER lumen (GO:0006621)4.95880268
7retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.29157279
8cell adhesion mediated by integrin (GO:0033627)4.21527621
9sequestering of metal ion (GO:0051238)4.15031900
10protein maturation by protein folding (GO:0022417)4.00675785
11nucleotide-sugar biosynthetic process (GO:0009226)3.84956126
12keratan sulfate catabolic process (GO:0042340)3.83167452
13basement membrane organization (GO:0071711)3.74508286
14activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.70609050
15regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.60980554
16positive regulation of nuclease activity (GO:0032075)3.60908308
17desmosome organization (GO:0002934)3.56195879
18collagen fibril organization (GO:0030199)3.53871697
19exocrine pancreas development (GO:0031017)3.51971235
20protein N-linked glycosylation via asparagine (GO:0018279)3.50910836
21vesicle coating (GO:0006901)3.45111498
22peptidyl-asparagine modification (GO:0018196)3.44429797
23regulation of type B pancreatic cell apoptotic process (GO:2000674)3.43562760
24endoplasmic reticulum unfolded protein response (GO:0030968)3.40127173
25cellular response to unfolded protein (GO:0034620)3.38034488
26regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.32910905
27regulation of nuclease activity (GO:0032069)3.32475986
28endocrine pancreas development (GO:0031018)3.31891314
29GDP-mannose metabolic process (GO:0019673)3.31015161
30protein carboxylation (GO:0018214)3.28070488
31peptidyl-glutamic acid carboxylation (GO:0017187)3.28070488
32cellular response to topologically incorrect protein (GO:0035967)3.27435068
33UDP-N-acetylglucosamine metabolic process (GO:0006047)3.25727961
34peptide hormone processing (GO:0016486)3.24902513
35protein N-linked glycosylation (GO:0006487)3.24358082
36ER overload response (GO:0006983)3.20673241
37proline biosynthetic process (GO:0006561)3.19697891
38endodermal cell differentiation (GO:0035987)3.16302182
39ER-nucleus signaling pathway (GO:0006984)3.15943444
40type B pancreatic cell proliferation (GO:0044342)3.13085328
41peptide catabolic process (GO:0043171)3.08948323
42regulation of plasminogen activation (GO:0010755)3.05526181
43regulation of metalloenzyme activity (GO:0048552)3.04820970
44nucleotide-sugar metabolic process (GO:0009225)3.03305588
45hemidesmosome assembly (GO:0031581)3.01758020
46ER to Golgi vesicle-mediated transport (GO:0006888)3.01299770
47extracellular fibril organization (GO:0043206)3.00652905
48dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.95211925
49cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.94779798
50chaperone-mediated protein folding (GO:0061077)2.94582924
51peptidyl-proline hydroxylation (GO:0019511)2.90940725
52glandular epithelial cell differentiation (GO:0002067)2.87500704
53mitochondrial calcium ion transport (GO:0006851)2.85536050
54negative regulation of fibrinolysis (GO:0051918)2.82948660
55regulation of hexokinase activity (GO:1903299)2.82554243
56regulation of glucokinase activity (GO:0033131)2.82554243
57chondrocyte development (GO:0002063)2.82087451
58regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.81525331
59peptidyl-proline modification (GO:0018208)2.76487146
60protein peptidyl-prolyl isomerization (GO:0000413)2.76055273
61actin filament depolymerization (GO:0030042)2.75940960
62endothelial cell morphogenesis (GO:0001886)2.74968831
63response to endoplasmic reticulum stress (GO:0034976)2.73553236
64regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.73149262
65folic acid-containing compound biosynthetic process (GO:0009396)2.70820971
66ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.70320133
67nucleotide transmembrane transport (GO:1901679)2.70311675
68cellular response to vitamin D (GO:0071305)2.68662233
69response to unfolded protein (GO:0006986)2.68352958
70positive regulation of extracellular matrix organization (GO:1903055)2.68196961
714-hydroxyproline metabolic process (GO:0019471)2.64396722
72type B pancreatic cell development (GO:0003323)2.63873428
73proline metabolic process (GO:0006560)2.63849546
74regulation of apoptotic process involved in morphogenesis (GO:1902337)2.62533294
75response to topologically incorrect protein (GO:0035966)2.61228926
76nucleobase-containing small molecule interconversion (GO:0015949)2.61143110
772-deoxyribonucleotide biosynthetic process (GO:0009265)2.61030197
78deoxyribose phosphate biosynthetic process (GO:0046385)2.61030197
79pteridine-containing compound biosynthetic process (GO:0042559)2.60528550
80DNA deamination (GO:0045006)2.59866600
81ribosomal small subunit assembly (GO:0000028)2.59296633
82SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.57229769
83lipopolysaccharide biosynthetic process (GO:0009103)2.56784303
84negative regulation of chondrocyte differentiation (GO:0032331)2.56593011
85cullin deneddylation (GO:0010388)2.56466507
86cell-substrate junction assembly (GO:0007044)2.55847779
87collagen metabolic process (GO:0032963)2.55508301
88glandular epithelial cell development (GO:0002068)2.53940495
89muscle cell migration (GO:0014812)2.53224913
90barbed-end actin filament capping (GO:0051016)2.51817878
91protein deneddylation (GO:0000338)2.51576467
92multicellular organismal macromolecule metabolic process (GO:0044259)2.51202605
93epithelial cell-cell adhesion (GO:0090136)2.50969451
94glutamine family amino acid biosynthetic process (GO:0009084)2.50530703
95regulation of fibrinolysis (GO:0051917)2.49880511
96apoptotic cell clearance (GO:0043277)2.48821436
97cellular copper ion homeostasis (GO:0006878)2.47285644
98protein targeting to ER (GO:0045047)2.46498258
99protein localization to endosome (GO:0036010)2.45586406
100wound healing, spreading of epidermal cells (GO:0035313)2.45197774
101cellular zinc ion homeostasis (GO:0006882)2.45164917
102retina vasculature morphogenesis in camera-type eye (GO:0061299)2.44697997
103midgut development (GO:0007494)2.44425362
104chondrocyte proliferation (GO:0035988)2.44240249
105cotranslational protein targeting to membrane (GO:0006613)2.44186660
106regulation of integrin-mediated signaling pathway (GO:2001044)2.44166267
107protein hydroxylation (GO:0018126)2.43253294
108positive regulation of osteoblast proliferation (GO:0033690)2.42945942
109protein heterotrimerization (GO:0070208)2.42924157
110regulation of extracellular matrix disassembly (GO:0010715)2.41563906
111deoxyribonucleotide biosynthetic process (GO:0009263)2.40472201
112multicellular organismal metabolic process (GO:0044236)2.40163565
113extracellular matrix disassembly (GO:0022617)2.39639197
114L-serine transport (GO:0015825)2.39438852
115protein localization to endoplasmic reticulum (GO:0070972)2.38532207
116fibrinolysis (GO:0042730)2.38509085
117regulation of protein activation cascade (GO:2000257)2.37438066
118very-low-density lipoprotein particle assembly (GO:0034379)2.36693426
119sequestering of extracellular ligand from receptor (GO:0035581)2.36264625
120adhesion of symbiont to host (GO:0044406)2.35976316
121notochord development (GO:0030903)2.35954090
122antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.35222914
123chondroitin sulfate biosynthetic process (GO:0030206)2.35070654
124planar cell polarity pathway involved in neural tube closure (GO:0090179)2.33860601
125heart contraction (GO:0060047)2.33025323
126heart process (GO:0003015)2.33025323
127collagen catabolic process (GO:0030574)2.32844317
128positive regulation of endothelial cell apoptotic process (GO:2000353)2.31749376
129hyaluronan catabolic process (GO:0030214)2.31624869
130regulation of complement activation (GO:0030449)2.31446456
131membrane protein ectodomain proteolysis (GO:0006509)2.30831282
132endocardial cushion development (GO:0003197)2.28156491
133negative regulation of protein localization to plasma membrane (GO:1903077)2.28126109
134positive regulation of collagen biosynthetic process (GO:0032967)2.27515560
135NADH metabolic process (GO:0006734)2.27362516
136deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.27362142
137establishment of protein localization to endoplasmic reticulum (GO:0072599)2.27170707
138nuclear envelope reassembly (GO:0031468)2.27143316
139mitotic nuclear envelope reassembly (GO:0007084)2.27143316
140dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.27056697
141multicellular organismal catabolic process (GO:0044243)2.26845085
142regulation of interleukin-8 secretion (GO:2000482)2.26372589
143cell aggregation (GO:0098743)2.26347757
144cartilage condensation (GO:0001502)2.26347757
145protein autoprocessing (GO:0016540)2.25523327
146cell redox homeostasis (GO:0045454)2.24553531
147adherens junction assembly (GO:0034333)2.24184391
148erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.24113734
149L-phenylalanine metabolic process (GO:0006558)2.24113734
150peptidyl-histidine modification (GO:0018202)2.23259751
151regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.23154518
152cochlea morphogenesis (GO:0090103)2.22982303
153urea cycle (GO:0000050)2.22840561
154embryo implantation (GO:0007566)2.22591496
155IMP biosynthetic process (GO:0006188)2.21127881
156purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.20297319
1573-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.20297319
158negative regulation of keratinocyte proliferation (GO:0010839)2.20282332
159lipopolysaccharide metabolic process (GO:0008653)2.19904036
160fibril organization (GO:0097435)2.19341285
161skin morphogenesis (GO:0043589)2.16200328

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.24093246
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.94099037
3E2F7_22180533_ChIP-Seq_HELA_Human3.64682658
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.40307559
5ZNF263_19887448_ChIP-Seq_K562_Human3.24491055
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.23355100
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.18326448
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.00695867
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.79932207
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.66621583
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.66128212
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.57261954
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.51527428
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.49903355
15* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.45700125
16ELK1_19687146_ChIP-ChIP_HELA_Human2.39050446
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.36444646
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.32346868
19DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.28762465
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.23436009
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.18787639
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15435902
23RBPJ_22232070_ChIP-Seq_NCS_Mouse2.15237038
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.12011751
25SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.07582599
26MYC_19030024_ChIP-ChIP_MESCs_Mouse2.07140353
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.02987732
28KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.00712913
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.98170730
30DCP1A_22483619_ChIP-Seq_HELA_Human1.95867820
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.95632432
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.94431788
33CLOCK_20551151_ChIP-Seq_293T_Human1.93604908
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.93286041
35CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.90576762
36ELK1_22589737_ChIP-Seq_MCF10A_Human1.86159395
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77984000
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77768137
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.76997419
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.75694973
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.72547538
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.68948985
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67922895
44RACK7_27058665_Chip-Seq_MCF-7_Human1.67645357
45GABP_19822575_ChIP-Seq_HepG2_Human1.67400267
46VDR_23849224_ChIP-Seq_CD4+_Human1.67370147
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.65404838
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.64048948
49GATA1_22025678_ChIP-Seq_K562_Human1.63962636
50DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.62806312
51ATF3_27146783_Chip-Seq_COLON_Human1.61644910
52TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.60407987
53HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.58658333
54HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.58568934
55TFEB_21752829_ChIP-Seq_HELA_Human1.57454776
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.56446104
57TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.55308296
58CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.54444078
59NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.53132978
60KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.53075783
61ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.52765181
62HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.52484821
63ESR1_21235772_ChIP-Seq_MCF-7_Human1.50625286
64* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46205603
65EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.45998645
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.45311712
67ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.45020751
68* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44996448
69* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.44702470
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44370987
71ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.43908757
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41632513
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.41075143
74* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39808803
75FOXP3_21729870_ChIP-Seq_TREG_Human1.39539306
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38780206
77CDX2_20551321_ChIP-Seq_CACO-2_Human1.38452030
78PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.37937899
79ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36905515
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36038050
81UBF1/2_26484160_Chip-Seq_HMECs_Human1.35619964
82IRF8_22096565_ChIP-ChIP_GC-B_Human1.35039260
83SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.33998582
84XRN2_22483619_ChIP-Seq_HELA_Human1.33315005
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.33043484
86NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33008522
87ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33006167
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32878694
89PPAR_26484153_Chip-Seq_NCI-H1993_Human1.32773855
90SALL4_18804426_ChIP-ChIP_XEN_Mouse1.31712343
91HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31504144
92CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31050345
93AR_21909140_ChIP-Seq_LNCAP_Human1.30083907
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29838157
95ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.29115270
96WT1_19549856_ChIP-ChIP_CCG9911_Human1.27825885
97TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27616492
98SOX2_27498859_Chip-Seq_STOMACH_Mouse1.27596524
99SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27416251
100TTF2_22483619_ChIP-Seq_HELA_Human1.27206251
101CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27044231
102MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27019300
103NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.26820278
104CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.26565716
105MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25780911
106MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25272947
107SOX17_20123909_ChIP-Seq_XEN_Mouse1.24561990
108FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24344219
109* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23869900
110STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22340777
111* SOX2_20726797_ChIP-Seq_SW620_Human1.21434806
112TP53_22127205_ChIP-Seq_IMR90_Human1.21006982
113* RXR_22158963_ChIP-Seq_LIVER_Mouse1.18491590
114EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17883197
115UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17439855
116BRD4_25478319_ChIP-Seq_HGPS_Human1.15203723
117ESR1_20079471_ChIP-ChIP_T-47D_Human1.14687197
118E2F1_21310950_ChIP-Seq_MCF-7_Human1.13772125
119CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13447255
120CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08243075
121MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.07382512
122STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07296767
123LXR_22158963_ChIP-Seq_LIVER_Mouse1.07092449
124* GATA6_25053715_ChIP-Seq_YYC3_Human1.06895540
125GATA4_21415370_ChIP-Seq_HL-1_Mouse1.06407486
126BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05124794
127LXR_22292898_ChIP-Seq_THP-1_Human1.05046207
128PPARA_22158963_ChIP-Seq_LIVER_Mouse1.04886687
129PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04596813
130SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.03539976
131SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.03539976
132TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.02983365
133CJUN_26792858_Chip-Seq_BT549_Human1.02395744
134ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02283216
135NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01320832
136FOXM1_23109430_ChIP-Seq_U2OS_Human0.98718923
137CHD1_26751641_Chip-Seq_LNCaP_Human0.98474850
138GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97293316
139TBX5_21415370_ChIP-Seq_HL-1_Mouse0.97015618
140SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96855172
141* NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95900376
142TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95168192
143FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95129245
144TP63_19390658_ChIP-ChIP_HaCaT_Human0.95128420
145TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.94921435
146RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91368606
147THAP11_20581084_ChIP-Seq_MESCs_Mouse0.89546506
148NANOG_18555785_ChIP-Seq_MESCs_Mouse0.89343273
149NANOG_16153702_ChIP-ChIP_HESCs_Human0.87644144

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.45620594
2MP0005503_abnormal_tendon_morphology3.99771554
3MP0002877_abnormal_melanocyte_morpholog3.63338258
4MP0006054_spinal_hemorrhage3.24858371
5MP0005275_abnormal_skin_tensile2.63767294
6MP0003279_aneurysm2.32546439
7MP0005623_abnormal_meninges_morphology2.30638781
8MP0010234_abnormal_vibrissa_follicle2.16228135
9MP0005360_urolithiasis2.09768332
10MP0003195_calcinosis2.06262918
11MP0005220_abnormal_exocrine_pancreas1.99620940
12MP0004272_abnormal_basement_membrane1.92150459
13MP0009384_cardiac_valve_regurgitation1.89112143
14MP0000678_abnormal_parathyroid_gland1.87604673
15MP0005508_abnormal_skeleton_morphology1.84220245
16MP0001542_abnormal_bone_strength1.80995535
17MP0002933_joint_inflammation1.70138594
18MP0004858_abnormal_nervous_system1.69152742
19MP0000163_abnormal_cartilage_morphology1.69085423
20MP0003950_abnormal_plasma_membrane1.68859534
21MP0010368_abnormal_lymphatic_system1.63578164
22MP0003693_abnormal_embryo_hatching1.62755817
23MP0005408_hypopigmentation1.62250240
24MP0010030_abnormal_orbit_morphology1.61844298
25MP0003283_abnormal_digestive_organ1.58000884
26MP0002896_abnormal_bone_mineralization1.57716880
27MP0009250_abnormal_appendicular_skeleto1.56666499
28MP0000013_abnormal_adipose_tissue1.56652209
29MP0005058_abnormal_lysosome_morphology1.54205995
30MP0003705_abnormal_hypodermis_morpholog1.52775601
31MP0005084_abnormal_gallbladder_morpholo1.51250559
32MP0001944_abnormal_pancreas_morphology1.51107704
33MP0004233_abnormal_muscle_weight1.48205986
34MP0003191_abnormal_cellular_cholesterol1.44804300
35MP0009840_abnormal_foam_cell1.42585775
36MP0003806_abnormal_nucleotide_metabolis1.42231050
37MP0002282_abnormal_trachea_morphology1.41946474
38MP0005390_skeleton_phenotype1.40854055
39MP0002060_abnormal_skin_morphology1.39035097
40MP0003123_paternal_imprinting1.38577545
41MP0003122_maternal_imprinting1.38550797
42MP0003186_abnormal_redox_activity1.37162475
43MP0009053_abnormal_anal_canal1.37048223
44MP0010386_abnormal_urinary_bladder1.35104791
45MP0002115_abnormal_skeleton_extremities1.34075192
46MP0009780_abnormal_chondrocyte_physiolo1.33621355
47MP0003091_abnormal_cell_migration1.33619080
48MP0005023_abnormal_wound_healing1.32611119
49MP0005257_abnormal_intraocular_pressure1.32261516
50MP0000003_abnormal_adipose_tissue1.31414382
51MP0004134_abnormal_chest_morphology1.31301468
52MP0002139_abnormal_hepatobiliary_system1.30923177
53MP0002693_abnormal_pancreas_physiology1.29186986
54MP0003942_abnormal_urinary_system1.28865119
55MP0009697_abnormal_copulation1.27513849
56MP0000049_abnormal_middle_ear1.26992031
57MP0003941_abnormal_skin_development1.26199906
58MP0008007_abnormal_cellular_replicative1.25351496
59MP0000534_abnormal_ureter_morphology1.24573850
60MP0005379_endocrine/exocrine_gland_phen1.23010683
61MP0001958_emphysema1.21376229
62MP0003868_abnormal_feces_composition1.21196853
63MP0001849_ear_inflammation1.20998171
64MP0003795_abnormal_bone_structure1.20627048
65MP0001666_abnormal_nutrient_absorption1.18118750
66MP0003566_abnormal_cell_adhesion1.17928226
67MP0001879_abnormal_lymphatic_vessel1.17208660
68MP0002113_abnormal_skeleton_development1.17140481
69MP0005501_abnormal_skin_physiology1.16177896
70MP0002163_abnormal_gland_morphology1.15400671
71MP0005085_abnormal_gallbladder_physiolo1.15078076
72MP0001243_abnormal_dermal_layer1.14273784
73MP0002938_white_spotting1.12416170
74MP0002796_impaired_skin_barrier1.12277092
75MP0001533_abnormal_skeleton_physiology1.12106631
76MP0000537_abnormal_urethra_morphology1.11459572
77MP0001915_intracranial_hemorrhage1.11057110
78MP0001299_abnormal_eye_distance/1.10288428
79MP0004782_abnormal_surfactant_physiolog1.10066445
80MP0002295_abnormal_pulmonary_circulatio1.08686925
81MP0004264_abnormal_extraembryonic_tissu1.07771990
82MP0000751_myopathy1.03564535
83MP0005451_abnormal_body_composition1.03329003
84MP0000566_synostosis1.02839948
85MP0005197_abnormal_uvea_morphology1.02443409
86MP0000613_abnormal_salivary_gland1.01295632
87MP0000462_abnormal_digestive_system1.00105732
88MP0005409_darkened_coat_color0.97646902
89MP0002109_abnormal_limb_morphology0.97174137
90MP0003183_abnormal_peptide_metabolism0.97121229
91MP0003943_abnormal_hepatobiliary_system0.96272065
92MP0002009_preneoplasia0.95903489
93MP0009379_abnormal_foot_pigmentation0.95105016
94MP0000516_abnormal_urinary_system0.89400072
95MP0005367_renal/urinary_system_phenotyp0.89400072
96MP0003385_abnormal_body_wall0.89295500
97MP0000467_abnormal_esophagus_morphology0.88589220
98MP0001270_distended_abdomen0.88519928
99MP0000733_abnormal_muscle_development0.88059470
100MP0000681_abnormal_thyroid_gland0.85955226
101MP0008932_abnormal_embryonic_tissue0.85501601
102MP0000762_abnormal_tongue_morphology0.84477457
103MP0003252_abnormal_bile_duct0.83577717
104MP0010352_gastrointestinal_tract_polyps0.83245221
105MP0000767_abnormal_smooth_muscle0.81865844
106MP0004957_abnormal_blastocyst_morpholog0.81851502
107MP0002177_abnormal_outer_ear0.80626020
108MP0003453_abnormal_keratinocyte_physiol0.80031536
109MP0000372_irregular_coat_pigmentation0.78683176
110MP0001661_extended_life_span0.78681561
111MP0002160_abnormal_reproductive_system0.78152860
112MP0001216_abnormal_epidermal_layer0.77991982
113MP0001919_abnormal_reproductive_system0.77940046
114MP0002108_abnormal_muscle_morphology0.77448981
115MP0002111_abnormal_tail_morphology0.77014557
116MP0003755_abnormal_palate_morphology0.76903040
117MP0000627_abnormal_mammary_gland0.76003153
118MP0001881_abnormal_mammary_gland0.74852354
119MP0005165_increased_susceptibility_to0.74698363
120MP0010771_integument_phenotype0.73937247
121MP0004043_abnormal_pH_regulation0.73530956
122MP0003115_abnormal_respiratory_system0.73046769
123MP0005164_abnormal_response_to0.72705695
124MP0005389_reproductive_system_phenotype0.72278004
125MP0003119_abnormal_digestive_system0.72155000
126MP0002932_abnormal_joint_morphology0.72034891
127MP0002928_abnormal_bile_duct0.71960530
128MP0002697_abnormal_eye_size0.71365961
129MP0009643_abnormal_urine_homeostasis0.71082390
130MP0002116_abnormal_craniofacial_bone0.71030623
131MP0005076_abnormal_cell_differentiation0.70731750
132MP0005193_abnormal_anterior_eye0.69581765
133MP0000538_abnormal_urinary_bladder0.69139954
134MP0000858_altered_metastatic_potential0.67891403
135MP0005365_abnormal_bile_salt0.67170484
136MP0000428_abnormal_craniofacial_morphol0.67132249
137MP0000432_abnormal_head_morphology0.66768276
138MP0004197_abnormal_fetal_growth/weight/0.66705691
139MP0003786_premature_aging0.66576706
140MP0002998_abnormal_bone_remodeling0.65892504
141MP0002086_abnormal_extraembryonic_tissu0.64770035
142MP0001175_abnormal_lung_morphology0.64183402
143MP0002098_abnormal_vibrissa_morphology0.64083588
144MP0008260_abnormal_autophagy0.63642540
145MP0008875_abnormal_xenobiotic_pharmacok0.62808030
146MP0001614_abnormal_blood_vessel0.62399856
147MP0002092_abnormal_eye_morphology0.61620472
148MP0003937_abnormal_limbs/digits/tail_de0.61417324
149MP0002089_abnormal_postnatal_growth/wei0.60999571
150MP0001730_embryonic_growth_arrest0.59883239

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)4.32612411
2Irregular epiphyses (HP:0010582)4.12541023
3Protrusio acetabuli (HP:0003179)4.01951653
4Flat capital femoral epiphysis (HP:0003370)3.68305425
5Premature rupture of membranes (HP:0001788)3.61565843
6Ankle contracture (HP:0006466)3.57245669
7Cervical subluxation (HP:0003308)3.56018461
8Vascular tortuosity (HP:0004948)3.54937332
9Vitreoretinal degeneration (HP:0000655)3.44994953
10Arterial tortuosity (HP:0005116)3.42838977
11Cupped ribs (HP:0000887)3.41329621
12Hypoglycemic coma (HP:0001325)3.35533513
13Beaking of vertebral bodies (HP:0004568)3.33106959
14Abnormal tarsal ossification (HP:0008369)3.30899845
15Bladder diverticulum (HP:0000015)3.27447445
16Hypoglycemic seizures (HP:0002173)3.20457240
17Abnormal foot bone ossification (HP:0010675)3.09087426
18Type I transferrin isoform profile (HP:0003642)3.08098791
19Thoracolumbar scoliosis (HP:0002944)3.07465281
20Neonatal short-limb short stature (HP:0008921)3.05428683
21Fragile skin (HP:0001030)3.02752419
22Symptomatic seizures (HP:0011145)2.96353581
23Vertebral compression fractures (HP:0002953)2.94574595
24Abnormality of the intrinsic pathway (HP:0010989)2.89718000
25Hyperinsulinemic hypoglycemia (HP:0000825)2.86264439
26Delayed epiphyseal ossification (HP:0002663)2.82420627
27Mitral stenosis (HP:0001718)2.81328576
28Osteolytic defects of the phalanges of the hand (HP:0009771)2.73853050
29Osteolytic defects of the hand bones (HP:0009699)2.73853050
30Deep venous thrombosis (HP:0002625)2.71785283
31Platyspondyly (HP:0000926)2.70813627
32Abnormal delivery (HP:0001787)2.69699363
33Biconcave vertebral bodies (HP:0004586)2.67837145
3411 pairs of ribs (HP:0000878)2.67613887
35Soft skin (HP:0000977)2.67405998
36Abnormal protein N-linked glycosylation (HP:0012347)2.66441753
37Abnormal protein glycosylation (HP:0012346)2.66441753
38Abnormal glycosylation (HP:0012345)2.66441753
39Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.66441753
40Cardiovascular calcification (HP:0011915)2.63381863
41Hyperglycemia (HP:0003074)2.62135451
42Generalized aminoaciduria (HP:0002909)2.59038996
43Abnormal pancreas size (HP:0012094)2.58161124
44Mildly elevated creatine phosphokinase (HP:0008180)2.55992444
45Shallow orbits (HP:0000586)2.55810689
46Osteoarthritis (HP:0002758)2.54560585
47Hypoplastic ischia (HP:0003175)2.54077108
48Irregular vertebral endplates (HP:0003301)2.53717944
49Small epiphyses (HP:0010585)2.53691829
50Upper limb amyotrophy (HP:0009129)2.53301001
51Distal upper limb amyotrophy (HP:0007149)2.53301001
52Abnormality of the vertebral endplates (HP:0005106)2.53268671
53Abnormality of the ischium (HP:0003174)2.48463953
54Elbow flexion contracture (HP:0002987)2.44066913
55Abnormality of dentin (HP:0010299)2.43090661
56Genu varum (HP:0002970)2.40656657
57Degeneration of anterior horn cells (HP:0002398)2.39378171
58Abnormality of the anterior horn cell (HP:0006802)2.39378171
59Hand muscle atrophy (HP:0009130)2.38819217
60Abnormality of the distal phalanges of the toes (HP:0010182)2.38062495
61Reduced antithrombin III activity (HP:0001976)2.37529548
62Nonimmune hydrops fetalis (HP:0001790)2.34546383
63Flattened epiphyses (HP:0003071)2.34106933
64Hyperextensible skin (HP:0000974)2.32088450
65Wormian bones (HP:0002645)2.30860805
66Flat acetabular roof (HP:0003180)2.30734618
67Ulnar bowing (HP:0003031)2.30482915
68Breech presentation (HP:0001623)2.28873403
69Metaphyseal irregularity (HP:0003025)2.28341296
70Abnormality of femoral epiphyses (HP:0006499)2.24864541
71Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.24864541
72Cerebral aneurysm (HP:0004944)2.23214823
73Metaphyseal cupping (HP:0003021)2.21459491
74Dilatation of the ascending aorta (HP:0005111)2.21038083
75Abnormality of the Achilles tendon (HP:0005109)2.20429829
76Patent foramen ovale (HP:0001655)2.20156455
77Achilles tendon contracture (HP:0001771)2.19792604
78Vascular calcification (HP:0004934)2.19433770
79Protuberant abdomen (HP:0001538)2.17906797
80Blue sclerae (HP:0000592)2.15733176
81Abnormality of carpal bone ossification (HP:0006257)2.15490874
82Pancreatic islet-cell hyperplasia (HP:0004510)2.14755388
83Abnormality of the acetabulum (HP:0003170)2.13113421
84Joint stiffness (HP:0001387)2.12384457
85Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.11300631
86Coxa vara (HP:0002812)2.11144446
87Osteomalacia (HP:0002749)2.09840303
88Mild short stature (HP:0003502)2.09441657
89Broad metatarsal (HP:0001783)2.08610262
90Joint laxity (HP:0001388)2.06100120
91Mitral valve prolapse (HP:0001634)2.04737108
92Aortic dissection (HP:0002647)2.04452679
93Trismus (HP:0000211)2.03868647
94Mesomelia (HP:0003027)2.03753773
95Abnormality of the femoral head (HP:0003368)2.03602855
96Asymmetry of the thorax (HP:0001555)2.03454155
97Abnormality of the epiphysis of the femoral head (HP:0010574)2.03047740
98Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.02465174
99Vertebral hypoplasia (HP:0008417)2.02465174
100Insulin-resistant diabetes mellitus (HP:0000831)2.01782409
101Peritonitis (HP:0002586)2.01007570
102Abnormal ossification of hand bones (HP:0005921)2.00509055
103Back pain (HP:0003418)1.99945799
104Short nail (HP:0001799)1.98654080
105Abnormality of endocrine pancreas physiology (HP:0012093)1.97231435
106Abnormality of the pancreatic islet cells (HP:0006476)1.97231435
107Hepatoblastoma (HP:0002884)1.97106366
108Disproportionate short-trunk short stature (HP:0003521)1.96033176
109Abnormality of monocarboxylic acid metabolism (HP:0010996)1.95833052
110Spinal rigidity (HP:0003306)1.95740943
111Abnormality of complement system (HP:0005339)1.94525026
112Ovoid vertebral bodies (HP:0003300)1.93915525
113Genu recurvatum (HP:0002816)1.93456468
114Abnormal vertebral ossification (HP:0100569)1.93029771
115Missing ribs (HP:0000921)1.92859426
116Mitral regurgitation (HP:0001653)1.91341646
117Decreased skull ossification (HP:0004331)1.90028874
118Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.89733700
119Poor head control (HP:0002421)1.89520649
120Aortic aneurysm (HP:0004942)1.89365441
121Stillbirth (HP:0003826)1.85321126
122Follicular hyperkeratosis (HP:0007502)1.85099906
123Type 1 muscle fiber predominance (HP:0003803)1.84859511
124Renal duplication (HP:0000075)1.84574622
125Abnormality of glycolysis (HP:0004366)1.83984618
126Atrophic scars (HP:0001075)1.82396592
127Spondylolisthesis (HP:0003302)1.81823475
128Thin skin (HP:0000963)1.81692053
129Aneurysm (HP:0002617)1.81507201
130Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.81032936
131Bowel diverticulosis (HP:0005222)1.79756206
132Natal tooth (HP:0000695)1.78588982
133Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.78534021
134Absent epiphyses (HP:0010577)1.78534021
135Generalized amyotrophy (HP:0003700)1.77849814
136Right ventricular cardiomyopathy (HP:0011663)1.77552999
137Increased connective tissue (HP:0009025)1.76103874
138Increased serum pyruvate (HP:0003542)1.75908956
139Disproportionate tall stature (HP:0001519)1.75827922
140Coxa valga (HP:0002673)1.75551251
141Hyperacusis (HP:0010780)1.74991249
142Abnormality of skull ossification (HP:0002703)1.74913749
143Pterygium (HP:0001059)1.74855125
144Coronal craniosynostosis (HP:0004440)1.73183223
145Thin bony cortex (HP:0002753)1.72474436
146Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.71772643
147Micromelia (HP:0002983)1.71369527
148Arthropathy (HP:0003040)1.71356691
149Hypoplasia of the odontoid process (HP:0003311)1.71346248
150Abnormality of the proximal phalanges of the hand (HP:0009834)1.71102496
151Intrahepatic cholestasis (HP:0001406)1.70940053
152Delayed cranial suture closure (HP:0000270)1.70873698
153Metaphyseal dysplasia (HP:0100255)1.70726730
154Inguinal hernia (HP:0000023)1.70649004
155Abdominal distention (HP:0003270)1.70455669
156Abnormality of glutamine family amino acid metabolism (HP:0010902)1.69975926
157Abnormality of the umbilical cord (HP:0010881)1.69882918
158Osteopenia (HP:0000938)1.69767455
159Abnormal hand bone ossification (HP:0010660)1.69077728
160Spinal cord compression (HP:0002176)1.68681815
161Long toe (HP:0010511)1.68628283
162Microglossia (HP:0000171)1.67099920
163Aortic regurgitation (HP:0001659)1.65965639
164Protruding ear (HP:0000411)1.65823433
165Wide anterior fontanel (HP:0000260)1.65458000
166Slender build (HP:0001533)1.65084835
167Distal lower limb amyotrophy (HP:0008944)1.64179920
168Neonatal death (HP:0003811)1.63567304
169Complement deficiency (HP:0004431)1.63501654
170Venous abnormality (HP:0002624)1.62618709
171Hypobetalipoproteinemia (HP:0003563)1.61985036
172Abnormality of aromatic amino acid family metabolism (HP:0004338)1.61726462
173Reduced subcutaneous adipose tissue (HP:0003758)1.61567711

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK3.11621333
2FRK2.69536320
3EIF2AK32.61867743
4ERN12.50742455
5STK38L2.49092159
6ERBB32.44834784
7INSRR2.39306511
8PAK42.38483890
9ZAK2.34175564
10MAP3K32.32140690
11TESK12.28602844
12TRIB32.11633675
13PIM22.07202240
14MAPK152.02734521
15BRSK22.01049490
16LATS21.94542614
17AKT31.93957856
18IRAK31.91706727
19NEK11.90518373
20FLT31.88910395
21NTRK11.79480429
22NME21.75254791
23EIF2AK11.73432789
24DDR21.70851540
25LMTK21.62266392
26ICK1.59269561
27MKNK11.58950781
28MAP3K121.54547750
29BCKDK1.53629663
30NEK91.53492344
31RIPK11.53231151
32FGFR41.50834073
33MKNK21.49704804
34NUAK11.49180920
35PIK3CG1.45302057
36EPHA31.43435045
37STK241.40749653
38LIMK11.36751673
39PKN21.33973864
40ERBB41.31450038
41LATS11.28115281
42TRPM71.27161900
43RPS6KA41.27071676
44TTN1.23127604
45ARAF1.21879732
46EPHA21.19878442
47PRKG21.15866397
48NME11.14844711
49MYLK1.12653169
50BRAF1.11004855
51SRPK11.10375356
52ABL21.07660441
53VRK11.06999210
54ACVR1B1.05818058
55TGFBR11.04898741
56EIF2AK21.04716932
57STK161.04153141
58PLK41.02395869
59EPHB11.01795394
60PIK3CA0.99014461
61ILK0.96888315
62MAP3K140.94615124
63SMG10.94170012
64BMPR1B0.93656292
65BMPR20.92579929
66IRAK40.92208716
67CDK80.90471874
68NLK0.88598453
69MAP3K20.88465535
70MET0.87435557
71TEC0.87344404
72KDR0.86425451
73MOS0.85949838
74STK380.85883956
75PLK30.85757157
76BUB10.85696662
77SCYL20.84117043
78STK30.83884676
79CDK120.83830550
80HIPK20.81458424
81JAK30.79197536
82PIM10.78656435
83PRKD30.77764823
84TAOK30.76386844
85BCR0.76205900
86EEF2K0.76160592
87KSR20.72490906
88TTK0.71357019
89MTOR0.70953758
90CDK60.69358462
91NEK60.67177498
92CHUK0.65883424
93WEE10.65610079
94DMPK0.65543753
95PDGFRA0.65395419
96PTK60.65362991
97PTK20.65065992
98PDK20.60910772
99YES10.59926611
100PDGFRB0.58797358
101IRAK10.58271288
102CDK70.56247328
103BRSK10.55985105
104MAP3K80.54790465
105AURKB0.54573268
106MAPKAPK30.52083160
107CAMK2G0.51570458
108MAP2K30.50863365
109PRKD20.50830135
110PRKCI0.50425352
111AKT20.49071300
112ROCK20.48456575
113DAPK30.48183956
114RPS6KB10.47604230
115CDK140.46493630
116CAMKK20.45886624
117TESK20.45012802
118CDC42BPA0.44994362
119MAP2K20.44001653
120MAP3K110.43963159
121CDK180.43473070
122VRK20.43150784
123FER0.42798943
124MAP3K60.42069587
125CDK150.41812579
126LRRK20.41606547
127CSNK2A10.41371173
128AURKA0.41244626
129TAOK20.41138197
130EPHB20.41106703
131PLK10.41014578
132PBK0.40504238
133SIK10.39990709
134CDK90.39983850
135PAK10.39657171
136CDK11A0.38886745
137RPS6KC10.38738759
138RPS6KL10.38738759
139BMX0.38279374
140RPS6KA60.38271322
141MAPKAPK20.38222034
142IKBKB0.38211174
143FGFR10.38170779
144CAMK2D0.37645344
145PAK20.37070859
146DYRK1B0.37045358
147MUSK0.37000972
148GSK3A0.34890133
149CSNK1A1L0.34857105
150MST1R0.34646942
151TGFBR20.34619542
152RPS6KB20.33817398

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030606.13713174
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.75222938
3Sulfur metabolism_Homo sapiens_hsa009203.16442751
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.15551070
5N-Glycan biosynthesis_Homo sapiens_hsa005102.44329716
6Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.41958686
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.38962259
8Selenocompound metabolism_Homo sapiens_hsa004502.03327569
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.02313847
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.96636261
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.94312557
12Cyanoamino acid metabolism_Homo sapiens_hsa004601.88790175
13Biosynthesis of amino acids_Homo sapiens_hsa012301.87367182
14One carbon pool by folate_Homo sapiens_hsa006701.81528044
15Proteasome_Homo sapiens_hsa030501.78320574
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.77876779
17Galactose metabolism_Homo sapiens_hsa000521.77135664
18Folate biosynthesis_Homo sapiens_hsa007901.76211398
19Arginine biosynthesis_Homo sapiens_hsa002201.68177248
20DNA replication_Homo sapiens_hsa030301.55834950
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.52253488
22Other glycan degradation_Homo sapiens_hsa005111.48777306
23Protein digestion and absorption_Homo sapiens_hsa049741.46698420
24Carbon metabolism_Homo sapiens_hsa012001.43760097
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.41834610
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.39296802
27ECM-receptor interaction_Homo sapiens_hsa045121.38377190
28Fatty acid elongation_Homo sapiens_hsa000621.37878724
29Pentose phosphate pathway_Homo sapiens_hsa000301.32550959
30Pyrimidine metabolism_Homo sapiens_hsa002401.32500476
31Starch and sucrose metabolism_Homo sapiens_hsa005001.31878918
32Base excision repair_Homo sapiens_hsa034101.31216952
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.27715910
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27633456
35Mismatch repair_Homo sapiens_hsa034301.27012532
36Ribosome_Homo sapiens_hsa030101.23363703
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.19045055
38RNA polymerase_Homo sapiens_hsa030201.18777335
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.17076833
40Arachidonic acid metabolism_Homo sapiens_hsa005901.12055234
41Pyruvate metabolism_Homo sapiens_hsa006201.11307454
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10763396
43Proteoglycans in cancer_Homo sapiens_hsa052051.10178047
44Legionellosis_Homo sapiens_hsa051341.09370402
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.07503116
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07258793
47Glutathione metabolism_Homo sapiens_hsa004801.05876822
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02231822
49Cell cycle_Homo sapiens_hsa041101.01256041
50Homologous recombination_Homo sapiens_hsa034401.01132314
51Nucleotide excision repair_Homo sapiens_hsa034200.97630361
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96171855
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94710127
54p53 signaling pathway_Homo sapiens_hsa041150.94482150
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.93948588
56Vitamin B6 metabolism_Homo sapiens_hsa007500.93819127
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92072437
58Thyroid cancer_Homo sapiens_hsa052160.89663144
59Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86621358
60Amoebiasis_Homo sapiens_hsa051460.82082619
61RNA transport_Homo sapiens_hsa030130.80371946
62Sphingolipid metabolism_Homo sapiens_hsa006000.79323477
63Basal transcription factors_Homo sapiens_hsa030220.79291780
64PPAR signaling pathway_Homo sapiens_hsa033200.78383888
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77504541
66TGF-beta signaling pathway_Homo sapiens_hsa043500.77083167
67Tryptophan metabolism_Homo sapiens_hsa003800.73554473
68RNA degradation_Homo sapiens_hsa030180.70602446
69Fatty acid degradation_Homo sapiens_hsa000710.69609466
70Antigen processing and presentation_Homo sapiens_hsa046120.68963065
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.68873510
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68038150
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67393811
74Fatty acid metabolism_Homo sapiens_hsa012120.67245687
75Non-homologous end-joining_Homo sapiens_hsa034500.67114886
76Purine metabolism_Homo sapiens_hsa002300.66798947
77Lysosome_Homo sapiens_hsa041420.66489691
78Arginine and proline metabolism_Homo sapiens_hsa003300.65033765
79Bile secretion_Homo sapiens_hsa049760.64586905
80Spliceosome_Homo sapiens_hsa030400.64531904
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64234643
82* Vibrio cholerae infection_Homo sapiens_hsa051100.64023784
83Chronic myeloid leukemia_Homo sapiens_hsa052200.63878030
84Fat digestion and absorption_Homo sapiens_hsa049750.62921049
85Tight junction_Homo sapiens_hsa045300.62697447
86Peroxisome_Homo sapiens_hsa041460.61541195
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61376947
88Focal adhesion_Homo sapiens_hsa045100.60625681
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59174360
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58863429
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58792206
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.58762301
93Renin-angiotensin system_Homo sapiens_hsa046140.58218224
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56812656
95Malaria_Homo sapiens_hsa051440.56181688
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55981112
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55791990
98Fructose and mannose metabolism_Homo sapiens_hsa000510.55068355
99Pancreatic cancer_Homo sapiens_hsa052120.54592280
100Complement and coagulation cascades_Homo sapiens_hsa046100.54493511
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54360297
102Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54194636
103Chemical carcinogenesis_Homo sapiens_hsa052040.54190237
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52818577
105Bladder cancer_Homo sapiens_hsa052190.51411773
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50503960
107Prostate cancer_Homo sapiens_hsa052150.50102773
108Adherens junction_Homo sapiens_hsa045200.49629138
109Metabolic pathways_Homo sapiens_hsa011000.48570571
110Phenylalanine metabolism_Homo sapiens_hsa003600.47841030
111Mineral absorption_Homo sapiens_hsa049780.47705622
112AMPK signaling pathway_Homo sapiens_hsa041520.47531394
113Phagosome_Homo sapiens_hsa041450.47510166
114Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45694663
115Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45175061
116MicroRNAs in cancer_Homo sapiens_hsa052060.43911894
117Fanconi anemia pathway_Homo sapiens_hsa034600.43846148
118Melanoma_Homo sapiens_hsa052180.43577972
119Shigellosis_Homo sapiens_hsa051310.43273624
120Tyrosine metabolism_Homo sapiens_hsa003500.40948045
121Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40714714
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40014383
123Histidine metabolism_Homo sapiens_hsa003400.38993751
124Vitamin digestion and absorption_Homo sapiens_hsa049770.37398422
125Steroid biosynthesis_Homo sapiens_hsa001000.37348246
126Thyroid hormone synthesis_Homo sapiens_hsa049180.37017617
127Retinol metabolism_Homo sapiens_hsa008300.34013426
128Small cell lung cancer_Homo sapiens_hsa052220.32905268
129Apoptosis_Homo sapiens_hsa042100.31728229
130Prion diseases_Homo sapiens_hsa050200.29657104
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29593466
132Viral carcinogenesis_Homo sapiens_hsa052030.29442071
133Sulfur relay system_Homo sapiens_hsa041220.29338445
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28981857
135Linoleic acid metabolism_Homo sapiens_hsa005910.27735094
136Hippo signaling pathway_Homo sapiens_hsa043900.27149298
137HTLV-I infection_Homo sapiens_hsa051660.26950303
138Epstein-Barr virus infection_Homo sapiens_hsa051690.26455630
139Primary bile acid biosynthesis_Homo sapiens_hsa001200.26316503
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26215498

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