KDELR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the KDEL endoplasmic reticulum protein retention receptor family. Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)7.07450501
2protein heterotrimerization (GO:0070208)6.37187738
3peptidyl-proline hydroxylation (GO:0019511)6.02945331
4cartilage development involved in endochondral bone morphogenesis (GO:0060351)5.67848357
5COPI coating of Golgi vesicle (GO:0048205)5.64498861
6Golgi transport vesicle coating (GO:0048200)5.64498861
7chondrocyte proliferation (GO:0035988)5.61740026
8keratan sulfate catabolic process (GO:0042340)5.40629694
9bone trabecula formation (GO:0060346)5.23786918
10protein hydroxylation (GO:0018126)5.12958771
11chondrocyte development (GO:0002063)4.89279234
12endodermal cell differentiation (GO:0035987)4.77445499
13skin morphogenesis (GO:0043589)4.71758653
14collagen metabolic process (GO:0032963)4.56171487
15collagen catabolic process (GO:0030574)4.45658232
16* maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.39738256
17type B pancreatic cell proliferation (GO:0044342)4.38045524
18sequestering of extracellular ligand from receptor (GO:0035581)4.33304553
19* protein retention in ER lumen (GO:0006621)4.24967195
20multicellular organismal macromolecule metabolic process (GO:0044259)4.24591866
21multicellular organismal catabolic process (GO:0044243)4.22334593
22dermatan sulfate biosynthetic process (GO:0030208)4.15797366
23multicellular organismal metabolic process (GO:0044236)4.12209177
24extracellular matrix disassembly (GO:0022617)4.07646535
25notochord development (GO:0030903)4.02913708
26cartilage condensation (GO:0001502)4.02697345
27cell aggregation (GO:0098743)4.02697345
28regulation of plasminogen activation (GO:0010755)4.01566035
29regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.01509762
30wound healing, spreading of epidermal cells (GO:0035313)3.93313680
31cell migration involved in heart development (GO:0060973)3.90543891
32basement membrane organization (GO:0071711)3.82596598
33dermatan sulfate metabolic process (GO:0030205)3.71803456
34extracellular fibril organization (GO:0043206)3.65328463
35COPII vesicle coating (GO:0048208)3.63250759
36regulation of integrin-mediated signaling pathway (GO:2001044)3.62744297
37negative regulation of chondrocyte differentiation (GO:0032331)3.50344416
38regulation of metalloenzyme activity (GO:0048552)3.48311548
39endothelial cell morphogenesis (GO:0001886)3.47743225
40regulation of extracellular matrix disassembly (GO:0010715)3.46876747
41fibril organization (GO:0097435)3.44513623
42positive regulation of endothelial cell apoptotic process (GO:2000353)3.40872663
43nucleotide-sugar biosynthetic process (GO:0009226)3.38424734
44membrane raft organization (GO:0031579)3.38006203
45regulation of tight junction assembly (GO:2000810)3.37885960
46positive regulation of extracellular matrix organization (GO:1903055)3.36338010
47UDP-N-acetylglucosamine metabolic process (GO:0006047)3.34650981
48negative regulation of cartilage development (GO:0061037)3.33339803
49substrate-dependent cell migration (GO:0006929)3.31827886
50polarized epithelial cell differentiation (GO:0030859)3.31374878
51embryonic skeletal joint morphogenesis (GO:0060272)3.31121213
52chondroitin sulfate biosynthetic process (GO:0030206)3.30206506
53extracellular matrix organization (GO:0030198)3.28933048
54extracellular structure organization (GO:0043062)3.27841509
55regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.26705514
56kidney mesenchyme development (GO:0072074)3.24394628
57positive regulation of epithelial to mesenchymal transition (GO:0010718)3.23300859
584-hydroxyproline metabolic process (GO:0019471)3.22112666
59actin filament depolymerization (GO:0030042)3.21680254
60retina vasculature morphogenesis in camera-type eye (GO:0061299)3.20130368
61wound healing, spreading of cells (GO:0044319)3.19492595
62vesicle coating (GO:0006901)3.14176867
63negative regulation of fatty acid transport (GO:2000192)3.12450698
64positive regulation of cartilage development (GO:0061036)3.09931960
65desmosome organization (GO:0002934)3.09708411
66atrioventricular valve morphogenesis (GO:0003181)3.09216720
67cell adhesion mediated by integrin (GO:0033627)3.07817885
68regulation of SMAD protein import into nucleus (GO:0060390)3.07513180
69craniofacial suture morphogenesis (GO:0097094)3.07305423
70mesenchymal-epithelial cell signaling (GO:0060638)3.06038564
71epithelial cell-cell adhesion (GO:0090136)3.04836706
72endocardial cushion development (GO:0003197)3.04472054
73peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.04311399
74mesodermal cell differentiation (GO:0048333)3.04074683
75protein maturation by protein folding (GO:0022417)3.01133552
76cellular response to vitamin D (GO:0071305)2.97473597
77cellular response to vitamin (GO:0071295)2.97167723
78response to gravity (GO:0009629)2.94968474
79substrate adhesion-dependent cell spreading (GO:0034446)2.94282033
80regulation of cartilage development (GO:0061035)2.94110380
81paraxial mesoderm development (GO:0048339)2.92420120
82peptidyl-proline modification (GO:0018208)2.91689649
83* activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.90848479
84protein localization to cell surface (GO:0034394)2.90495078
85positive regulation of osteoblast proliferation (GO:0033690)2.89553949
86barbed-end actin filament capping (GO:0051016)2.86043017
87muscle cell migration (GO:0014812)2.85421229
88ventricular cardiac muscle cell development (GO:0055015)2.83421500
89negative regulation of stem cell proliferation (GO:2000647)2.82785078
90cartilage development (GO:0051216)2.80716052
91endochondral ossification (GO:0001958)2.80659982
92replacement ossification (GO:0036075)2.80659982
93cranial suture morphogenesis (GO:0060363)2.79993012
94* positive regulation of nuclease activity (GO:0032075)2.78299808
95apoptotic cell clearance (GO:0043277)2.78003831
96tooth mineralization (GO:0034505)2.77797655
97regulation of transforming growth factor beta2 production (GO:0032909)2.77737227
98hemidesmosome assembly (GO:0031581)2.77266839
99positive regulation of stem cell differentiation (GO:2000738)2.77247128
100peptidyl-glutamic acid carboxylation (GO:0017187)2.76713189
101protein carboxylation (GO:0018214)2.76713189
102extracellular matrix assembly (GO:0085029)2.76437953
103hippo signaling (GO:0035329)2.76185508
104outer ear morphogenesis (GO:0042473)2.75676318
105positive regulation of actin filament depolymerization (GO:0030836)2.74749164
106regulation of chondrocyte differentiation (GO:0032330)2.74619659
107extracellular regulation of signal transduction (GO:1900115)2.74065309
108extracellular negative regulation of signal transduction (GO:1900116)2.74065309
109hyaluronan catabolic process (GO:0030214)2.73597456
110establishment of apical/basal cell polarity (GO:0035089)2.73136245
111metanephric mesenchyme development (GO:0072075)2.71999409
112regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.71426713
113glomerular basement membrane development (GO:0032836)2.70925278
114retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.70296876
115lipopolysaccharide biosynthetic process (GO:0009103)2.68466158
116heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.66639431
117negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.62581834
118negative regulation of catenin import into nucleus (GO:0035414)2.62319521
119* endoplasmic reticulum unfolded protein response (GO:0030968)2.62114401
120vascular endothelial growth factor signaling pathway (GO:0038084)2.61536363
121cell-substrate junction assembly (GO:0007044)2.60307716
122regulation of gastrulation (GO:0010470)2.60089877
123response to follicle-stimulating hormone (GO:0032354)2.59820140
124response to redox state (GO:0051775)2.59493550
125positive regulation of blood vessel endothelial cell migration (GO:0043536)2.59137424
126negative regulation of smooth muscle cell migration (GO:0014912)2.58683752
127neuron projection extension involved in neuron projection guidance (GO:1902284)2.58471690
128axon extension involved in axon guidance (GO:0048846)2.58471690
129negative regulation of axon extension involved in axon guidance (GO:0048843)2.50814381
130regulation of osteoblast proliferation (GO:0033688)2.50313209
131protein N-linked glycosylation via asparagine (GO:0018279)2.50224271
132pericardium development (GO:0060039)2.49368694
133peptidyl-asparagine modification (GO:0018196)2.47292366
134virion attachment to host cell (GO:0019062)2.46690958
135adhesion of symbiont to host cell (GO:0044650)2.46690958
136cell migration involved in sprouting angiogenesis (GO:0002042)2.46243806
137regulation of apoptotic process involved in morphogenesis (GO:1902337)2.45129530

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* TRIM28_21343339_ChIP-Seq_HEK293_Human6.99415896
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.56098741
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.92913673
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.03360991
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.57207947
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.51568820
7* CLOCK_20551151_ChIP-Seq_293T_Human3.11010379
8* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse3.04117499
9HIF1A_21447827_ChIP-Seq_MCF-7_Human2.88258654
10TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.81954570
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.53149742
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.51810719
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.38162931
14WT1_19549856_ChIP-ChIP_CCG9911_Human2.33687815
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.29415349
16CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.28020215
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.24826530
18SALL4_18804426_ChIP-ChIP_XEN_Mouse2.22321960
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.21908713
20CJUN_26792858_Chip-Seq_BT549_Human2.17272719
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.10167354
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.09113773
23BRD4_25478319_ChIP-Seq_HGPS_Human2.05041449
24* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.04715012
25ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.95268163
26GATA2_21666600_ChIP-Seq_HMVEC_Human1.90919214
27SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.81179226
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.78534858
29ELK1_22589737_ChIP-Seq_MCF10A_Human1.77852975
30KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.77700544
31KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.77700544
32KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.77700544
33ATF3_27146783_Chip-Seq_COLON_Human1.75387052
34POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.75216220
35HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.74205935
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.73595156
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.70896055
38SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.70682685
39SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.70682685
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.62133841
41AR_21909140_ChIP-Seq_LNCAP_Human1.57782576
42HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.54509883
43ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.54326263
44TCF3_18692474_ChIP-Seq_MEFs_Mouse1.50922995
45NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.48964742
46TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48330938
47JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47250744
48UBF1/2_26484160_Chip-Seq_HMECs_Human1.46984453
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.46444591
50KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.46141203
51PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.44416763
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44293451
53EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.44187061
54WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.43963959
55TP53_20018659_ChIP-ChIP_R1E_Mouse1.43847656
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.43845191
57* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.43771777
58TP53_22127205_ChIP-Seq_IMR90_Human1.42709062
59ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.40250414
60ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38856553
61JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36998473
62PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36966345
63TP53_16413492_ChIP-PET_HCT116_Human1.33855418
64SOX2_20726797_ChIP-Seq_SW620_Human1.33445021
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.33259705
66UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31340120
67ZNF263_19887448_ChIP-Seq_K562_Human1.29467862
68* EOMES_21245162_ChIP-Seq_HESCs_Human1.29295050
69RXR_22158963_ChIP-Seq_LIVER_Mouse1.29220456
70SMC1_22415368_ChIP-Seq_MEFs_Mouse1.28496685
71FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.27577000
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24666137
73P300_27058665_Chip-Seq_ZR-75-30cells_Human1.23291111
74ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22853992
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22759974
76CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21223960
77PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.20622385
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20210857
79SA1_22415368_ChIP-Seq_MEFs_Mouse1.19993870
80* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.19983750
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18966207
82NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18966207
83MYC_19030024_ChIP-ChIP_MESCs_Mouse1.18632052
84RACK7_27058665_Chip-Seq_MCF-7_Human1.16708267
85EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16355609
86TP53_23651856_ChIP-Seq_MEFs_Mouse1.14325578
87SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13328360
88EP300_21415370_ChIP-Seq_HL-1_Mouse1.12590233
89SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.10844061
90SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08285840
91TFEB_21752829_ChIP-Seq_HELA_Human1.07991720
92E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06978338
93NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06238690
94SOX17_20123909_ChIP-Seq_XEN_Mouse1.05895242
95CDX2_20551321_ChIP-Seq_CACO-2_Human1.05406751
96SMC3_22415368_ChIP-Seq_MEFs_Mouse1.03884464
97GATA4_21415370_ChIP-Seq_HL-1_Mouse1.02871971
98ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99908314
99* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99632730
100KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99196116
101P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98339544
102RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98252624
103E2F7_22180533_ChIP-Seq_HELA_Human0.97408375
104* NANOG_16153702_ChIP-ChIP_HESCs_Human0.97214068
105KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94810852
106ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94460713
107FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94276290
108NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93463628
109GATA4_25053715_ChIP-Seq_YYC3_Human0.93108674
110MYC_18358816_ChIP-ChIP_MESCs_Mouse0.92879834
111ELK1_19687146_ChIP-ChIP_HELA_Human0.91933003
112ESR1_20079471_ChIP-ChIP_T-47D_Human0.91876179
113TP53_18474530_ChIP-ChIP_U2OS_Human0.91520807
114ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90864800
115SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90235419
116TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89752393
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89479762
118PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.89183426
119CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.88134100
120TBX20_22328084_ChIP-Seq_HEART_Mouse0.87287752
121TBX20_22080862_ChIP-Seq_HEART_Mouse0.87287752
122TP63_23658742_ChIP-Seq_EP156T_Human0.86053607
123GATA3_24758297_ChIP-Seq_MCF-7_Human0.85503423
124NFI_21473784_ChIP-Seq_ESCs_Mouse0.84896400
125FOXO3_23340844_ChIP-Seq_DLD1_Human0.83713796
126PPARA_22158963_ChIP-Seq_LIVER_Mouse0.83413706
127CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.83328576
128CSB_26484114_Chip-Seq_FIBROBLAST_Human0.83199125
129Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82185585
130PIAS1_25552417_ChIP-Seq_VCAP_Human0.80784012
131DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.78845715
132PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.77877722

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.53627489
2MP0005503_abnormal_tendon_morphology5.92743878
3MP0005275_abnormal_skin_tensile4.90228471
4MP0003705_abnormal_hypodermis_morpholog3.63771467
5MP0003279_aneurysm3.40341872
6MP0004272_abnormal_basement_membrane3.31245002
7MP0003950_abnormal_plasma_membrane3.19889900
8MP0009384_cardiac_valve_regurgitation2.75505467
9MP0001958_emphysema2.69784173
10MP0005623_abnormal_meninges_morphology2.68176657
11MP0005508_abnormal_skeleton_morphology2.45940030
12MP0006054_spinal_hemorrhage2.42611223
13MP0001542_abnormal_bone_strength2.40433611
14MP0009250_abnormal_appendicular_skeleto2.19862822
15MP0010030_abnormal_orbit_morphology2.05010037
16MP0005023_abnormal_wound_healing2.03117597
17MP0002282_abnormal_trachea_morphology1.95097827
18MP0003566_abnormal_cell_adhesion1.94682600
19MP0004134_abnormal_chest_morphology1.93360542
20MP0002896_abnormal_bone_mineralization1.89121009
21MP0002933_joint_inflammation1.81537915
22MP0000163_abnormal_cartilage_morphology1.80232598
23MP0002108_abnormal_muscle_morphology1.74652382
24MP0005360_urolithiasis1.70915832
25MP0002060_abnormal_skin_morphology1.70898169
26MP0003283_abnormal_digestive_organ1.68292955
27MP0005257_abnormal_intraocular_pressure1.65485357
28MP0002115_abnormal_skeleton_extremities1.58061053
29MP0005390_skeleton_phenotype1.53434033
30MP0002295_abnormal_pulmonary_circulatio1.52544641
31MP0010352_gastrointestinal_tract_polyps1.50743663
32MP0001243_abnormal_dermal_layer1.40982398
33MP0005171_absent_coat_pigmentation1.40972269
34MP0002113_abnormal_skeleton_development1.40443841
35MP0003942_abnormal_urinary_system1.38020694
36MP0003385_abnormal_body_wall1.36853976
37MP0003091_abnormal_cell_migration1.34741619
38MP0001299_abnormal_eye_distance/1.34049896
39MP0003941_abnormal_skin_development1.25250553
40MP0000762_abnormal_tongue_morphology1.22124656
41MP0003755_abnormal_palate_morphology1.19701007
42MP0009053_abnormal_anal_canal1.17629105
43MP0000767_abnormal_smooth_muscle1.16150291
44MP0002932_abnormal_joint_morphology1.14558825
45MP0000534_abnormal_ureter_morphology1.13780372
46MP0002089_abnormal_postnatal_growth/wei1.13511854
47MP0000733_abnormal_muscle_development1.13321092
48MP0003191_abnormal_cellular_cholesterol1.12353786
49MP0000049_abnormal_middle_ear1.11638135
50MP0003795_abnormal_bone_structure1.11619859
51MP0002109_abnormal_limb_morphology1.10369606
52MP0010386_abnormal_urinary_bladder1.09549579
53MP0000013_abnormal_adipose_tissue1.09455676
54MP0002877_abnormal_melanocyte_morpholog1.07157859
55MP0003115_abnormal_respiratory_system1.05174766
56MP0001661_extended_life_span1.03219401
57MP0001533_abnormal_skeleton_physiology1.03168708
58MP0005408_hypopigmentation1.02645803
59MP0000749_muscle_degeneration1.01970237
60MP0010368_abnormal_lymphatic_system1.01725195
61MP0000432_abnormal_head_morphology1.01482134
62MP0003123_paternal_imprinting1.00259013
63MP0002111_abnormal_tail_morphology0.99982518
64MP0000750_abnormal_muscle_regeneration0.99501982
65MP0005197_abnormal_uvea_morphology0.97425840
66MP0000428_abnormal_craniofacial_morphol0.96789311
67MP0002249_abnormal_larynx_morphology0.95658585
68MP0002116_abnormal_craniofacial_bone0.95616496
69MP0005084_abnormal_gallbladder_morpholo0.94204496
70MP0003937_abnormal_limbs/digits/tail_de0.93420727
71MP0002998_abnormal_bone_remodeling0.92944450
72MP0005165_increased_susceptibility_to0.91426749
73MP0004197_abnormal_fetal_growth/weight/0.88857900
74MP0005076_abnormal_cell_differentiation0.87984298
75MP0003935_abnormal_craniofacial_develop0.84985702
76MP0000003_abnormal_adipose_tissue0.84234411
77MP0005220_abnormal_exocrine_pancreas0.83627950
78MP0000751_myopathy0.83137104
79MP0003119_abnormal_digestive_system0.81929730
80MP0009697_abnormal_copulation0.81414014
81MP0002233_abnormal_nose_morphology0.81058119
82MP0000538_abnormal_urinary_bladder0.80005752
83MP0005164_abnormal_response_to0.79769329
84MP0004233_abnormal_muscle_weight0.79628528
85MP0003186_abnormal_redox_activity0.78764037
86MP0002114_abnormal_axial_skeleton0.76590923
87MP0001915_intracranial_hemorrhage0.75050187
88MP0001175_abnormal_lung_morphology0.74099357
89MP0009840_abnormal_foam_cell0.73271829
90MP0002128_abnormal_blood_circulation0.71045072
91MP0000516_abnormal_urinary_system0.70928120
92MP0005367_renal/urinary_system_phenotyp0.70928120
93MP0003252_abnormal_bile_duct0.68049255
94MP0001614_abnormal_blood_vessel0.67957499
95MP0003868_abnormal_feces_composition0.66453332
96MP0002168_other_aberrant_phenotype0.65612057
97MP0004084_abnormal_cardiac_muscle0.64798674
98MP0001879_abnormal_lymphatic_vessel0.64387072
99MP0004957_abnormal_blastocyst_morpholog0.64026197
100MP0002177_abnormal_outer_ear0.63469339
101MP0000537_abnormal_urethra_morphology0.62341369
102MP0009780_abnormal_chondrocyte_physiolo0.62075207
103MP0002254_reproductive_system_inflammat0.61551226
104MP0005595_abnormal_vascular_smooth0.60205282
105MP0000343_altered_response_to0.59382844
106MP0002925_abnormal_cardiovascular_devel0.59147704
107MP0005193_abnormal_anterior_eye0.58883660
108MP0000759_abnormal_skeletal_muscle0.58627187
109MP0002084_abnormal_developmental_patter0.57290372
110MP0003448_altered_tumor_morphology0.56099333
111MP0001270_distended_abdomen0.56049663
112MP0001348_abnormal_lacrimal_gland0.55594818
113MP0004858_abnormal_nervous_system0.55551810
114MP0010771_integument_phenotype0.55436791
115MP0005330_cardiomyopathy0.55065463
116MP0002938_white_spotting0.54720236
117MP0000747_muscle_weakness0.53477924
118MP0000462_abnormal_digestive_system0.53373394
119MP0000858_altered_metastatic_potential0.53284015
120MP0002697_abnormal_eye_size0.53215758
121MP0002085_abnormal_embryonic_tissue0.52857202
122MP0005058_abnormal_lysosome_morphology0.52462136
123MP0004883_abnormal_blood_vessel0.52002836
124MP0000467_abnormal_esophagus_morphology0.47949234
125MP0002269_muscular_atrophy0.47529099
126MP0005395_other_phenotype0.47357797

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.33136355
2Premature rupture of membranes (HP:0001788)6.77508771
3Neonatal short-limb short stature (HP:0008921)4.68064214
4Epiphyseal dysplasia (HP:0002656)4.46394414
5Cervical subluxation (HP:0003308)4.06534669
6Abnormality of dentin (HP:0010299)4.04903594
7Irregular epiphyses (HP:0010582)3.92099327
8Soft skin (HP:0000977)3.91019650
9Aortic dissection (HP:0002647)3.75893899
10Ankle contracture (HP:0006466)3.73138813
11Cupped ribs (HP:0000887)3.69145746
12Wormian bones (HP:0002645)3.61465005
13Biconcave vertebral bodies (HP:0004586)3.54151927
14Shallow orbits (HP:0000586)3.53168585
15Atrophic scars (HP:0001075)3.46336517
16Vertebral compression fractures (HP:0002953)3.42445193
17Spondylolisthesis (HP:0003302)3.40380142
18Hypoplastic ischia (HP:0003175)3.35291266
19Small epiphyses (HP:0010585)3.29704723
20Aortic aneurysm (HP:0004942)3.24585641
21Coxa vara (HP:0002812)3.15790386
22Cerebral aneurysm (HP:0004944)3.15278547
23Blue sclerae (HP:0000592)3.14778124
24Mild short stature (HP:0003502)3.09721937
25Metaphyseal cupping (HP:0003021)3.09301382
26Cardiovascular calcification (HP:0011915)3.08264895
27Vitreoretinal degeneration (HP:0000655)3.07923148
28Abnormality of the acetabulum (HP:0003170)3.04687683
29Genu recurvatum (HP:0002816)3.02310530
30Osteoarthritis (HP:0002758)3.02102622
31Bladder diverticulum (HP:0000015)2.99410908
32Follicular hyperkeratosis (HP:0007502)2.99291492
33Abnormal tarsal ossification (HP:0008369)2.99275910
34Peritonitis (HP:0002586)2.97400311
35Platyspondyly (HP:0000926)2.95664102
36Abnormality of the ischium (HP:0003174)2.92844608
37Dilatation of the ascending aorta (HP:0005111)2.92649388
38Delayed epiphyseal ossification (HP:0002663)2.89868935
39Flat capital femoral epiphysis (HP:0003370)2.84851983
40Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.82416883
41Flat acetabular roof (HP:0003180)2.82067033
42Beaking of vertebral bodies (HP:0004568)2.79082990
43Spinal rigidity (HP:0003306)2.78221917
44Osteolytic defects of the phalanges of the hand (HP:0009771)2.76978022
45Osteolytic defects of the hand bones (HP:0009699)2.76978022
46Broad metatarsal (HP:0001783)2.75297039
47Slender build (HP:0001533)2.68520310
48Mitral stenosis (HP:0001718)2.67263503
49Fragile skin (HP:0001030)2.67168260
50Type 1 muscle fiber predominance (HP:0003803)2.65995952
51Genu varum (HP:0002970)2.50861261
52Hip contracture (HP:0003273)2.50587591
53Mesomelia (HP:0003027)2.48744933
54Aortic regurgitation (HP:0001659)2.47774004
55Abnormal foot bone ossification (HP:0010675)2.46180765
56Mitral valve prolapse (HP:0001634)2.45237529
57Reduced subcutaneous adipose tissue (HP:0003758)2.42646458
58Abnormal vertebral ossification (HP:0100569)2.39741136
59Abnormal delivery (HP:0001787)2.37689133
60Redundant skin (HP:0001582)2.34938983
61Flattened epiphyses (HP:0003071)2.34554194
62Spinal cord compression (HP:0002176)2.32698644
63Breech presentation (HP:0001623)2.29965254
64Hyperextensible skin (HP:0000974)2.27471541
65Limited hip movement (HP:0008800)2.27349847
66Elbow flexion contracture (HP:0002987)2.26921963
67Thoracolumbar scoliosis (HP:0002944)2.26006135
68Abnormality of carpal bone ossification (HP:0006257)2.25404226
69Joint stiffness (HP:0001387)2.24278569
70Abnormality of the proximal phalanges of the hand (HP:0009834)2.22850146
71Coronal craniosynostosis (HP:0004440)2.22618941
72Mitral regurgitation (HP:0001653)2.21970506
73Increased connective tissue (HP:0009025)2.19551094
74Abnormality of femoral epiphyses (HP:0006499)2.18404572
75Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.18404572
76Vascular tortuosity (HP:0004948)2.17839126
77Broad long bones (HP:0005622)2.16626070
78Wrist flexion contracture (HP:0001239)2.15386636
79Vascular calcification (HP:0004934)2.14922876
80Joint laxity (HP:0001388)2.14195309
81Entropion (HP:0000621)2.12938580
82Aortic valve stenosis (HP:0001650)2.12848403
83Wide anterior fontanel (HP:0000260)2.12471941
84Ulnar bowing (HP:0003031)2.12159558
85Thin ribs (HP:0000883)2.11713933
86Delayed gross motor development (HP:0002194)2.10841787
87Microglossia (HP:0000171)2.09509161
88Abnormality of the vertebral endplates (HP:0005106)2.08558037
89Aneurysm (HP:0002617)2.08105676
90Overgrowth (HP:0001548)2.06720244
91Decreased skull ossification (HP:0004331)2.06645847
92Upper limb amyotrophy (HP:0009129)2.06187294
93Distal upper limb amyotrophy (HP:0007149)2.06187294
94Abnormality of the calcaneus (HP:0008364)2.05473870
95Irregular vertebral endplates (HP:0003301)2.04851182
96Knee flexion contracture (HP:0006380)2.03969340
97Premature skin wrinkling (HP:0100678)2.03659453
98Mildly elevated creatine phosphokinase (HP:0008180)2.03498100
99Abnormal ossification of hand bones (HP:0005921)2.03233546
100Ectopia lentis (HP:0001083)2.01517311
101Metaphyseal dysplasia (HP:0100255)2.01182947
102Limited elbow extension (HP:0001377)2.01132296
103Bell-shaped thorax (HP:0001591)2.00697089
104Inguinal hernia (HP:0000023)1.98982424
105Disproportionate tall stature (HP:0001519)1.98225629
106Generalized amyotrophy (HP:0003700)1.97914491
107Abnormality of the umbilical cord (HP:0010881)1.97601290
108Flared iliac wings (HP:0002869)1.96862153
109Femoral bowing (HP:0002980)1.96410176
110Ovoid vertebral bodies (HP:0003300)1.96240400
111Protruding ear (HP:0000411)1.96097864
112Hand muscle atrophy (HP:0009130)1.95845894
113Tibial bowing (HP:0002982)1.95759923
114Delayed closure of the anterior fontanelle (HP:0001476)1.94773853
115Radial bowing (HP:0002986)1.94060522
116Abnormality of the epiphysis of the femoral head (HP:0010574)1.92350842
117Abnormality of the 2nd finger (HP:0004100)1.92273248
118Hypoplasia of the odontoid process (HP:0003311)1.91998199
119Arterial tortuosity (HP:0005116)1.91743806
120Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.91185159
121Absent epiphyses (HP:0010577)1.91185159
122Increased variability in muscle fiber diameter (HP:0003557)1.89965985
123Delayed cranial suture closure (HP:0000270)1.88778865
124Abnormality of skull ossification (HP:0002703)1.88723634
125Thin skin (HP:0000963)1.88517087
126Bowel diverticulosis (HP:0005222)1.88132522
127Short nail (HP:0001799)1.85923658
128Broad phalanx (HP:0006009)1.85681472
129Round ear (HP:0100830)1.85640892
130Abnormality of the distal phalanges of the toes (HP:0010182)1.84706216
131Nonimmune hydrops fetalis (HP:0001790)1.83281797
132Broad ribs (HP:0000885)1.82592609
133Abnormality of the fetal cardiovascular system (HP:0010948)1.81488694
134Abnormal umbilical cord blood vessels (HP:0011403)1.81488694
135Single umbilical artery (HP:0001195)1.81488694
136Hypoplasia of the iris (HP:0007676)1.80694945
137Glucose intolerance (HP:0000833)1.77185056
138Renal duplication (HP:0000075)1.74656544
139Hypoalphalipoproteinemia (HP:0003233)1.73770420
140Natal tooth (HP:0000695)1.73002866
141Spinal cord lesions (HP:0100561)1.72551172
142Syringomyelia (HP:0003396)1.72551172
143Congenital glaucoma (HP:0001087)1.72190410
144Abnormal hand bone ossification (HP:0010660)1.70807807

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.41963931
2LATS23.61949595
3MAP3K123.28694029
4TRIB33.12592018
5TESK12.75802683
6STK38L2.67615179
7LATS12.54877179
8PDGFRA2.51746773
9EPHA22.45922921
10TTN2.43994699
11MST1R2.42595170
12ERN12.37183238
13NME22.32465350
14MAP3K32.32403541
15PIM22.28710038
16LIMK12.23162576
17PKN21.97098105
18RPS6KA41.91872499
19PBK1.91200694
20PAK21.80905349
21FER1.48964276
22MET1.48412025
23PTK21.46154322
24EPHB21.44772567
25EPHA31.44546715
26AKT31.43819157
27TESK21.40475740
28STK31.39858179
29ERBB31.34531059
30TRPM71.31124816
31SCYL21.28121894
32STK381.26025694
33ERBB41.25438719
34ZAK1.19914070
35MYLK1.17551712
36LMTK21.16097045
37BMX1.14805492
38SIK11.10599565
39PIK3CG1.09069847
40PRKG21.06161805
41PAK41.05551786
42PIK3CA1.05079269
43PAK31.04830995
44MOS1.03690201
45MUSK1.01612817
46CDK80.98696010
47NEK90.97121185
48ROCK10.96882154
49NME10.96249797
50EIF2AK10.93763671
51FGFR10.93645471
52PTK60.91229637
53LRRK20.90945128
54FLT30.90838907
55ILK0.90760174
56EIF2AK30.90465622
57MAPKAPK30.89379025
58ADRBK10.89285518
59BUB10.87557403
60PRKD20.86820195
61TGFBR20.86641387
62STK240.85312142
63MAP3K20.84897038
64TAOK20.84264757
65DMPK0.84042777
66TGFBR10.83329935
67MAP2K10.83174835
68PAK10.79492782
69MELK0.79078955
70MAP3K80.78802658
71RPS6KB20.78451415
72MTOR0.77614322
73IRAK30.77470871
74PDK20.75993182
75PLK20.75979161
76STK160.75795574
77MAP2K20.73958854
78PLK30.73174997
79PTK2B0.73163841
80FRK0.68995037
81RAF10.66680346
82PAK60.65773399
83BRSK20.64887241
84CDK70.64245435
85TAOK10.63186329
86PRKCI0.63056502
87DAPK30.62357849
88NUAK10.62311418
89BCR0.61367315
90PASK0.61221360
91PDGFRB0.60976735
92WEE10.60023845
93BRSK10.58081845
94MST40.56312347
95PRKD30.56127342
96PRKCE0.55668992
97GSK3A0.55170971
98GRK70.53531816
99CDC42BPA0.52127071
100CDK120.49637659
101RIPK10.49152644
102MAP3K110.47706614
103BCKDK0.47621472
104MAP2K30.46991836
105MAP3K60.46983112
106WNK40.45422661
107AURKB0.45412681
108ROCK20.45405573
109PRKD10.44516269
110STK390.42376717
111STK100.42063752
112CAMK2G0.41901451
113KDR0.41648762
114AURKA0.40999700
115FGFR40.39979674
116NEK10.39942021
117INSR0.39268703
118ACVR1B0.38332610
119ARAF0.37845808
120TTK0.37571847
121MKNK10.37492896
122CAMK2D0.35987721
123MAPKAPK20.35865427
124PLK10.35613918
125PIM10.35568127
126EPHB10.33881193
127CDK90.33700352
128ABL20.32397899
129NTRK10.32177985
130MAPKAPK50.31630183
131WNK10.31546899
132CDK60.31394278
133MAP3K50.31380190
134GRK50.29481384

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045125.04810321
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.20194565
3Protein digestion and absorption_Homo sapiens_hsa049743.95009479
4Focal adhesion_Homo sapiens_hsa045102.97900886
5Sulfur metabolism_Homo sapiens_hsa009202.67075549
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.61257744
7Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.37172671
8TGF-beta signaling pathway_Homo sapiens_hsa043502.29914484
9Protein export_Homo sapiens_hsa030602.10240975
10Proteoglycans in cancer_Homo sapiens_hsa052052.03529903
11Bladder cancer_Homo sapiens_hsa052192.00462896
12Hippo signaling pathway_Homo sapiens_hsa043901.96293023
13Small cell lung cancer_Homo sapiens_hsa052221.96158728
14PI3K-Akt signaling pathway_Homo sapiens_hsa041511.85775523
15p53 signaling pathway_Homo sapiens_hsa041151.83557415
16Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.77767023
17Complement and coagulation cascades_Homo sapiens_hsa046101.77172955
18Adherens junction_Homo sapiens_hsa045201.76421451
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.74839797
20Amoebiasis_Homo sapiens_hsa051461.72574884
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.65517765
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61574779
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.60955167
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.56409467
25Malaria_Homo sapiens_hsa051441.52568132
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.48588588
27Basal cell carcinoma_Homo sapiens_hsa052171.41400441
28Hedgehog signaling pathway_Homo sapiens_hsa043401.40027526
29MicroRNAs in cancer_Homo sapiens_hsa052061.39352851
30N-Glycan biosynthesis_Homo sapiens_hsa005101.38024530
31Dilated cardiomyopathy_Homo sapiens_hsa054141.34104628
32Vitamin B6 metabolism_Homo sapiens_hsa007501.30957704
33Sulfur relay system_Homo sapiens_hsa041221.28748966
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23750715
35Cell cycle_Homo sapiens_hsa041101.16088714
36Biosynthesis of amino acids_Homo sapiens_hsa012301.14624370
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11530159
38Prostate cancer_Homo sapiens_hsa052151.11373505
39Melanoma_Homo sapiens_hsa052181.10671029
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10537505
41RNA transport_Homo sapiens_hsa030131.08630703
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03601128
43Arginine biosynthesis_Homo sapiens_hsa002201.03305199
44Galactose metabolism_Homo sapiens_hsa000521.02604247
45Regulation of actin cytoskeleton_Homo sapiens_hsa048101.02146611
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.00877618
47Pentose phosphate pathway_Homo sapiens_hsa000300.99733217
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99510225
49Arginine and proline metabolism_Homo sapiens_hsa003300.97197508
50Renin-angiotensin system_Homo sapiens_hsa046140.97154430
51Proteasome_Homo sapiens_hsa030500.95637247
52Fatty acid elongation_Homo sapiens_hsa000620.95619098
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94357006
54Shigellosis_Homo sapiens_hsa051310.94130920
55Ribosome_Homo sapiens_hsa030100.93980862
56Pathways in cancer_Homo sapiens_hsa052000.93853114
57One carbon pool by folate_Homo sapiens_hsa006700.90741657
58Tight junction_Homo sapiens_hsa045300.90052349
59HTLV-I infection_Homo sapiens_hsa051660.89628313
60Chronic myeloid leukemia_Homo sapiens_hsa052200.89312226
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85965322
62Glutathione metabolism_Homo sapiens_hsa004800.85132880
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82810040
64Viral carcinogenesis_Homo sapiens_hsa052030.81402172
65HIF-1 signaling pathway_Homo sapiens_hsa040660.79702476
66Apoptosis_Homo sapiens_hsa042100.78054673
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77415559
68Arachidonic acid metabolism_Homo sapiens_hsa005900.77388355
69Wnt signaling pathway_Homo sapiens_hsa043100.76499707
70Pyruvate metabolism_Homo sapiens_hsa006200.76349532
71Carbon metabolism_Homo sapiens_hsa012000.75472511
72Other glycan degradation_Homo sapiens_hsa005110.75363073
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75033202
74Toxoplasmosis_Homo sapiens_hsa051450.73886952
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73570574
76Folate biosynthesis_Homo sapiens_hsa007900.70670017
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70554339
78Viral myocarditis_Homo sapiens_hsa054160.69882490
79Sphingolipid metabolism_Homo sapiens_hsa006000.67041096
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.66316805
81Phagosome_Homo sapiens_hsa041450.65736552
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.64319924
83Thyroid cancer_Homo sapiens_hsa052160.64150536
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61431346
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60826584
86TNF signaling pathway_Homo sapiens_hsa046680.60711325
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60428472
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60268469
89Rap1 signaling pathway_Homo sapiens_hsa040150.60005177
90Starch and sucrose metabolism_Homo sapiens_hsa005000.59599161
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.58923306
92Nucleotide excision repair_Homo sapiens_hsa034200.57126501
93Legionellosis_Homo sapiens_hsa051340.56233728
94Pancreatic cancer_Homo sapiens_hsa052120.55127278
95Thyroid hormone synthesis_Homo sapiens_hsa049180.54061996
96Hepatitis B_Homo sapiens_hsa051610.53563259
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53481770
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.53176235
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.51806426
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50577118
101Chemical carcinogenesis_Homo sapiens_hsa052040.49941439
102Selenocompound metabolism_Homo sapiens_hsa004500.49490109
103Mineral absorption_Homo sapiens_hsa049780.48339838
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47949341
105Colorectal cancer_Homo sapiens_hsa052100.47755617
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46633108
107Primary bile acid biosynthesis_Homo sapiens_hsa001200.46313597
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46212386
109Fat digestion and absorption_Homo sapiens_hsa049750.44738568
110Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44337650
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.44238820
112Tyrosine metabolism_Homo sapiens_hsa003500.44226434
113Lysosome_Homo sapiens_hsa041420.42508739
114Pancreatic secretion_Homo sapiens_hsa049720.42191617
115mTOR signaling pathway_Homo sapiens_hsa041500.39724940
116Glioma_Homo sapiens_hsa052140.39526055
117Prion diseases_Homo sapiens_hsa050200.39148499
118Endocytosis_Homo sapiens_hsa041440.38995476
119Metabolic pathways_Homo sapiens_hsa011000.37562127
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35943032
121Platelet activation_Homo sapiens_hsa046110.35851896
122PPAR signaling pathway_Homo sapiens_hsa033200.35821086
123* Vibrio cholerae infection_Homo sapiens_hsa051100.35238966
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33870473
125Epstein-Barr virus infection_Homo sapiens_hsa051690.30782070
126Lysine degradation_Homo sapiens_hsa003100.30693736
127Melanogenesis_Homo sapiens_hsa049160.30574923
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30165173
129Renal cell carcinoma_Homo sapiens_hsa052110.28717977
130Fructose and mannose metabolism_Homo sapiens_hsa000510.25786359
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.25437986
132FoxO signaling pathway_Homo sapiens_hsa040680.25097346
133Gap junction_Homo sapiens_hsa045400.24734472
134RNA polymerase_Homo sapiens_hsa030200.24544997
135Pyrimidine metabolism_Homo sapiens_hsa002400.24120391
136Endometrial cancer_Homo sapiens_hsa052130.23968333

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »