KDM1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.18753684
2nuclear pore organization (GO:0006999)5.16911751
3pre-miRNA processing (GO:0031054)4.44847457
4establishment of integrated proviral latency (GO:0075713)4.32469949
5DNA unwinding involved in DNA replication (GO:0006268)4.18830538
6regulation of gene silencing by RNA (GO:0060966)4.16604903
7regulation of posttranscriptional gene silencing (GO:0060147)4.16604903
8regulation of gene silencing by miRNA (GO:0060964)4.16604903
9protein-DNA complex disassembly (GO:0032986)3.87427886
10nucleosome disassembly (GO:0006337)3.87427886
11pore complex assembly (GO:0046931)3.81448704
12mitotic nuclear envelope disassembly (GO:0007077)3.73765441
13heterochromatin organization (GO:0070828)3.68981686
14mitotic sister chromatid cohesion (GO:0007064)3.67047256
15DNA replication-dependent nucleosome assembly (GO:0006335)3.66607322
16DNA replication-dependent nucleosome organization (GO:0034723)3.66607322
17protein complex localization (GO:0031503)3.61558938
18protein localization to kinetochore (GO:0034501)3.58864735
19membrane disassembly (GO:0030397)3.58437196
20nuclear envelope disassembly (GO:0051081)3.58437196
21regulation of RNA export from nucleus (GO:0046831)3.54299865
22paraxial mesoderm development (GO:0048339)3.48531371
23DNA synthesis involved in DNA repair (GO:0000731)3.47371419
24regulation of helicase activity (GO:0051095)3.44605976
25telomere maintenance via semi-conservative replication (GO:0032201)3.40437445
26DNA duplex unwinding (GO:0032508)3.37799595
27DNA geometric change (GO:0032392)3.37400648
28* negative regulation of histone methylation (GO:0031061)3.35501727
29chromatin assembly (GO:0031497)3.33394345
30positive regulation of SMAD protein import into nucleus (GO:0060391)3.31871600
31* regulation of histone H3-K9 methylation (GO:0051570)3.31064818
32sister chromatid segregation (GO:0000819)3.30911321
33peptidyl-arginine omega-N-methylation (GO:0035247)3.27018090
34IMP biosynthetic process (GO:0006188)3.26950428
35double-strand break repair via nonhomologous end joining (GO:0006303)3.25286458
36non-recombinational repair (GO:0000726)3.25286458
37mitotic metaphase plate congression (GO:0007080)3.20584321
38chromosome condensation (GO:0030261)3.19741990
39negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.17837096
40somatic hypermutation of immunoglobulin genes (GO:0016446)3.17024521
41somatic diversification of immune receptors via somatic mutation (GO:0002566)3.17024521
42regulation of sister chromatid cohesion (GO:0007063)3.16374747
43mitotic chromosome condensation (GO:0007076)3.16345921
44dosage compensation (GO:0007549)3.14464187
45peptidyl-arginine methylation (GO:0018216)3.13827269
46peptidyl-arginine N-methylation (GO:0035246)3.13827269
47DNA replication initiation (GO:0006270)3.13143307
48regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.11782348
49negative regulation of DNA repair (GO:0045738)3.10143722
50positive regulation of mitotic sister chromatid separation (GO:1901970)3.09507987
51positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.09507987
52positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.09507987
53protein localization to chromosome, centromeric region (GO:0071459)3.08076927
54positive regulation of chromosome segregation (GO:0051984)3.07837909
55establishment of viral latency (GO:0019043)3.07778015
56mitotic sister chromatid segregation (GO:0000070)3.06575779
57histone arginine methylation (GO:0034969)3.03470435
58folic acid-containing compound biosynthetic process (GO:0009396)3.02247725
59histone H2A monoubiquitination (GO:0035518)2.99697025
60regulation of translational fidelity (GO:0006450)2.99233247
61spliceosomal tri-snRNP complex assembly (GO:0000244)2.97017490
62regulation of centriole replication (GO:0046599)2.96705785
63cellular protein complex localization (GO:0034629)2.96515677
64metaphase plate congression (GO:0051310)2.95368435
65mitotic recombination (GO:0006312)2.93756344
66formation of translation preinitiation complex (GO:0001731)2.93651572
67regulation of hippo signaling (GO:0035330)2.93273269
68negative regulation of RNA splicing (GO:0033119)2.92478522
69DNA replication checkpoint (GO:0000076)2.91888157
70planar cell polarity pathway involved in neural tube closure (GO:0090179)2.91736364
71regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.91558889
72DNA ligation (GO:0006266)2.90267018
73kinetochore organization (GO:0051383)2.89615105
74positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.88355179
75positive regulation of cell cycle G2/M phase transition (GO:1902751)2.88355179
76notochord development (GO:0030903)2.87581028
77telomere maintenance via recombination (GO:0000722)2.87337891
78chromatin remodeling at centromere (GO:0031055)2.84968298
79mRNA transport (GO:0051028)2.84862278
80CENP-A containing nucleosome assembly (GO:0034080)2.84750365
81maturation of SSU-rRNA (GO:0030490)2.83618321
82RNA stabilization (GO:0043489)2.81842388
83mRNA stabilization (GO:0048255)2.81842388
84DNA packaging (GO:0006323)2.81614545
85regulation of telomere maintenance via telomerase (GO:0032210)2.81451663
86convergent extension (GO:0060026)2.81108931
87establishment of apical/basal cell polarity (GO:0035089)2.80138390
88regulation of SMAD protein import into nucleus (GO:0060390)2.79468777
89nucleobase biosynthetic process (GO:0046112)2.77634233
90regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.77546712
91gene silencing by RNA (GO:0031047)2.77516838
92DNA replication-independent nucleosome organization (GO:0034724)2.76060060
93DNA replication-independent nucleosome assembly (GO:0006336)2.76060060
94negative regulation of mRNA processing (GO:0050686)2.76059482
95nuclear envelope organization (GO:0006998)2.75123231
96protein localization to chromosome (GO:0034502)2.75112688
97IMP metabolic process (GO:0046040)2.74124589
98DNA strand elongation involved in DNA replication (GO:0006271)2.73779166
99regulation of chromosome segregation (GO:0051983)2.73346007
100protein export from nucleus (GO:0006611)2.73134670
101chromatin assembly or disassembly (GO:0006333)2.72737085
102peptidyl-lysine dimethylation (GO:0018027)2.72311950
103regulation of spindle organization (GO:0090224)2.70981784
104regulation of gene silencing (GO:0060968)2.70935465
105DNA conformation change (GO:0071103)2.70053511
106negative regulation of mitotic sister chromatid separation (GO:2000816)2.69912560
107negative regulation of sister chromatid segregation (GO:0033046)2.69912560
108negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.69912560
109negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.69912560
110negative regulation of mitotic sister chromatid segregation (GO:0033048)2.69912560
111DNA topological change (GO:0006265)2.67245734
112ATP-dependent chromatin remodeling (GO:0043044)2.66930896
113negative regulation of chromosome segregation (GO:0051985)2.65096206
114regulation of DNA damage checkpoint (GO:2000001)2.64469760
115establishment of monopolar cell polarity (GO:0061162)2.64118897
116establishment or maintenance of monopolar cell polarity (GO:0061339)2.64118897
117mitotic spindle checkpoint (GO:0071174)2.64082247
118regulation of nucleobase-containing compound transport (GO:0032239)2.63815731
119regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.63296989
120mitotic spindle assembly checkpoint (GO:0007094)2.62827568
121regulation of mitotic spindle organization (GO:0060236)2.61668398
122histone H4-K12 acetylation (GO:0043983)2.61285673
123establishment of chromosome localization (GO:0051303)2.59435852
124regulation of mitotic metaphase/anaphase transition (GO:0030071)2.59292681
125chromosome segregation (GO:0007059)2.59093398
126spindle checkpoint (GO:0031577)2.58855475
127regulation of centrosome cycle (GO:0046605)2.58344526
128DNA strand elongation (GO:0022616)2.58079669
129histone H3-K9 methylation (GO:0051567)2.57944620
130RNA transport (GO:0050658)2.57909623
131establishment of RNA localization (GO:0051236)2.57909623
132nucleic acid transport (GO:0050657)2.57909623
133spindle assembly checkpoint (GO:0071173)2.57901803
134sister chromatid cohesion (GO:0007062)2.57363680
135negative regulation of mRNA metabolic process (GO:1903312)2.57348129
136regulation of sister chromatid segregation (GO:0033045)2.56965006
137regulation of mitotic sister chromatid separation (GO:0010965)2.56965006
138regulation of mitotic sister chromatid segregation (GO:0033047)2.56965006
139* negative regulation of histone modification (GO:0031057)2.56588487

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.23912455
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.87112297
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.62722427
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.55057308
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.23238310
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.17662551
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.07324432
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.96308717
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.87286833
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.55010236
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.47209083
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.45346429
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.45346429
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.45346429
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.44862293
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.35734749
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.32277310
18ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.14679425
19SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.13305945
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11238934
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.10634421
22ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.05989210
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04483220
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.01640164
25MYC_22102868_ChIP-Seq_BL_Human1.98391352
26SOX2_18555785_ChIP-Seq_MESCs_Mouse1.92748220
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.91149926
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87206145
29NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.86877838
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.85500627
31NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.84709478
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.77650634
33AR_21909140_ChIP-Seq_LNCAP_Human1.76616513
34TCF3_18692474_ChIP-Seq_MEFs_Mouse1.76287557
35* XRN2_22483619_ChIP-Seq_HELA_Human1.75361624
36PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.75288368
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.74002300
38SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.72859924
39SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.69910336
40TCF3_18692474_ChIP-Seq_MESCs_Mouse1.68735938
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.67316852
42HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.65299151
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61119491
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59466218
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.58853389
46* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58201389
47NANOG_21062744_ChIP-ChIP_HESCs_Human1.50501610
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.48749763
49KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.48718558
50KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.47758607
51CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.46302142
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40623527
53CIITA_25753668_ChIP-Seq_RAJI_Human1.39733046
54HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39322180
55* TTF2_22483619_ChIP-Seq_HELA_Human1.38757801
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.36369153
57NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.34350402
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33997935
59ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33459892
60CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.33174063
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31465296
62DCP1A_22483619_ChIP-Seq_HELA_Human1.30177307
63CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.29969442
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29020362
65SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.28505316
66ZFP281_27345836_Chip-Seq_ESCs_Mouse1.28472579
67EST1_17652178_ChIP-ChIP_JURKAT_Human1.28316444
68TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28086534
69CLOCK_20551151_ChIP-Seq_293T_Human1.26835094
70KDM5A_27292631_Chip-Seq_BREAST_Human1.26028549
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24998734
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24897284
73PKCTHETA_26484144_Chip-Seq_BREAST_Human1.21873368
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21707232
75ETS1_20019798_ChIP-Seq_JURKAT_Human1.20823995
76POU5F1_16518401_ChIP-PET_MESCs_Mouse1.20208770
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19975948
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18842430
79E2F1_18555785_ChIP-Seq_MESCs_Mouse1.17624226
80SOX2_16153702_ChIP-ChIP_HESCs_Human1.16068921
81TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.16029512
82CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15724955
83POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.14115829
84WT1_19549856_ChIP-ChIP_CCG9911_Human1.14034028
85SOX17_20123909_ChIP-Seq_XEN_Mouse1.13979161
86SOX2_18692474_ChIP-Seq_MESCs_Mouse1.12014383
87* VDR_23849224_ChIP-Seq_CD4+_Human1.10286847
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09948349
89JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.09709293
90NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.09690895
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09177947
92ELK1_19687146_ChIP-ChIP_HELA_Human1.08499934
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08475329
94ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06918655
95PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05506316
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05281793
97ZNF263_19887448_ChIP-Seq_K562_Human1.04104452
98NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03596071
99TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.01948135
100FOXP3_21729870_ChIP-Seq_TREG_Human1.01680771
101POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01275042
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01218755
103NANOG_16153702_ChIP-ChIP_HESCs_Human1.01137438
104* CHD1_26751641_Chip-Seq_LNCaP_Human0.99825967
105GATA1_26923725_Chip-Seq_HPCs_Mouse0.99680641
106THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99384685
107GABP_19822575_ChIP-Seq_HepG2_Human0.99136167
108MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97240074
109HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97055629
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96827721
111SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96675341
112TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95823236
113CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95775131
114* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.94976191
115DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94080399
116TFEB_21752829_ChIP-Seq_HELA_Human0.92342930
117* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88345362
118FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.86860443
119ERG_20887958_ChIP-Seq_HPC-7_Mouse0.82535879

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.36272521
2MP0010094_abnormal_chromosome_stability3.06685752
3MP0000537_abnormal_urethra_morphology3.06123494
4MP0003111_abnormal_nucleus_morphology2.99207005
5MP0004957_abnormal_blastocyst_morpholog2.92767694
6MP0003123_paternal_imprinting2.87105377
7MP0003693_abnormal_embryo_hatching2.82723195
8* MP0003077_abnormal_cell_cycle2.69920100
9MP0010352_gastrointestinal_tract_polyps2.54409791
10MP0005076_abnormal_cell_differentiation2.34590662
11MP0003121_genomic_imprinting2.34298286
12MP0003890_abnormal_embryonic-extraembry2.25187949
13MP0008058_abnormal_DNA_repair2.11959972
14MP0008007_abnormal_cellular_replicative2.10749420
15* MP0001730_embryonic_growth_arrest2.08187420
16* MP0002084_abnormal_developmental_patter2.04245326
17MP0004197_abnormal_fetal_growth/weight/1.99784030
18MP0003119_abnormal_digestive_system1.98939781
19MP0000566_synostosis1.98729892
20MP0000350_abnormal_cell_proliferation1.96727059
21MP0008877_abnormal_DNA_methylation1.91306570
22* MP0002085_abnormal_embryonic_tissue1.88198619
23MP0001672_abnormal_embryogenesis/_devel1.87043679
24MP0005380_embryogenesis_phenotype1.87043679
25MP0003705_abnormal_hypodermis_morpholog1.84460116
26MP0002653_abnormal_ependyma_morphology1.83260886
27MP0008932_abnormal_embryonic_tissue1.75237671
28MP0001697_abnormal_embryo_size1.72772534
29MP0010030_abnormal_orbit_morphology1.71709990
30MP0001293_anophthalmia1.71080790
31MP0009053_abnormal_anal_canal1.70727588
32MP0010307_abnormal_tumor_latency1.70697342
33MP0003567_abnormal_fetal_cardiomyocyte1.70527780
34MP0003984_embryonic_growth_retardation1.67887008
35MP0002088_abnormal_embryonic_growth/wei1.67738268
36MP0004133_heterotaxia1.65749050
37MP0002086_abnormal_extraembryonic_tissu1.65069655
38MP0003787_abnormal_imprinting1.63582534
39MP0005367_renal/urinary_system_phenotyp1.62489233
40MP0000516_abnormal_urinary_system1.62489233
41MP0003283_abnormal_digestive_organ1.51924831
42MP0009697_abnormal_copulation1.49494500
43MP0001346_abnormal_lacrimal_gland1.48814122
44MP0003122_maternal_imprinting1.43107240
45MP0003315_abnormal_perineum_morphology1.41758541
46* MP0002080_prenatal_lethality1.41618822
47MP0001299_abnormal_eye_distance/1.38294469
48MP0003937_abnormal_limbs/digits/tail_de1.34911241
49MP0003861_abnormal_nervous_system1.29075561
50MP0009703_decreased_birth_body1.26186549
51MP0005623_abnormal_meninges_morphology1.25932943
52MP0000428_abnormal_craniofacial_morphol1.24835844
53MP0003935_abnormal_craniofacial_develop1.24815336
54MP0001849_ear_inflammation1.24781874
55MP0002697_abnormal_eye_size1.22952174
56MP0003385_abnormal_body_wall1.22577103
57MP0010234_abnormal_vibrissa_follicle1.21922452
58MP0004185_abnormal_adipocyte_glucose1.21043313
59MP0006292_abnormal_olfactory_placode1.20822580
60MP0003941_abnormal_skin_development1.18665853
61MP0003115_abnormal_respiratory_system1.18059909
62MP0003755_abnormal_palate_morphology1.14147174
63MP0000733_abnormal_muscle_development1.13935959
64MP0002877_abnormal_melanocyte_morpholog1.13575430
65MP0003942_abnormal_urinary_system1.13198594
66MP0001286_abnormal_eye_development1.12367963
67MP0009278_abnormal_bone_marrow1.12109464
68MP0002009_preneoplasia1.11692665
69MP0000432_abnormal_head_morphology1.10503707
70MP0002111_abnormal_tail_morphology1.09665371
71MP0002092_abnormal_eye_morphology1.09468522
72MP0003718_maternal_effect1.08832827
73MP0005187_abnormal_penis_morphology1.08539678
74MP0002210_abnormal_sex_determination1.07805809
75MP0000534_abnormal_ureter_morphology1.06135514
76MP0005257_abnormal_intraocular_pressure1.06092283
77MP0004272_abnormal_basement_membrane1.06033446
78MP0000579_abnormal_nail_morphology1.05370345
79MP0009672_abnormal_birth_weight1.02912969
80MP0003786_premature_aging1.02027006
81MP0002925_abnormal_cardiovascular_devel1.01448325
82MP0005248_abnormal_Harderian_gland0.99111974
83MP0002089_abnormal_postnatal_growth/wei0.97097224
84MP0000049_abnormal_middle_ear0.95882186
85MP0000762_abnormal_tongue_morphology0.95372807
86MP0002116_abnormal_craniofacial_bone0.95286140
87MP0001145_abnormal_male_reproductive0.94194290
88MP0003943_abnormal_hepatobiliary_system0.93844393
89MP0006072_abnormal_retinal_apoptosis0.92934564
90* MP0000313_abnormal_cell_death0.91187773
91MP0004808_abnormal_hematopoietic_stem0.91170929
92MP0002932_abnormal_joint_morphology0.86385634
93MP0002396_abnormal_hematopoietic_system0.85871630
94MP0002234_abnormal_pharynx_morphology0.85811937
95MP0002114_abnormal_axial_skeleton0.85484703
96MP0002233_abnormal_nose_morphology0.85398993
97MP0004858_abnormal_nervous_system0.84941906
98MP0010630_abnormal_cardiac_muscle0.84685683
99MP0000569_abnormal_digit_pigmentation0.84327052
100MP0002081_perinatal_lethality0.84008636
101MP0002938_white_spotting0.83543456
102MP0000490_abnormal_crypts_of0.83232279
103MP0003566_abnormal_cell_adhesion0.83002486
104MP0001915_intracranial_hemorrhage0.82612196
105MP0002249_abnormal_larynx_morphology0.82413016
106MP0000462_abnormal_digestive_system0.81740602
107MP0002282_abnormal_trachea_morphology0.81685716
108MP0001929_abnormal_gametogenesis0.79408573
109MP0008789_abnormal_olfactory_epithelium0.79232154
110MP0003938_abnormal_ear_development0.79069903
111MP0000653_abnormal_sex_gland0.76747363
112MP0004233_abnormal_muscle_weight0.76672529
113MP0004264_abnormal_extraembryonic_tissu0.76116022
114MP0002751_abnormal_autonomic_nervous0.75537498
115MP0001661_extended_life_span0.74207045
116MP0000778_abnormal_nervous_system0.72531044
117MP0005501_abnormal_skin_physiology0.72435264
118* MP0002152_abnormal_brain_morphology0.71791108
119MP0000678_abnormal_parathyroid_gland0.70844536
120MP0008770_decreased_survivor_rate0.70610539
121MP0005394_taste/olfaction_phenotype0.67990626

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.12138633
2Colon cancer (HP:0003003)3.83903412
3Astrocytoma (HP:0009592)3.46399553
4Abnormality of the astrocytes (HP:0100707)3.46399553
5Medulloblastoma (HP:0002885)3.36502916
6Volvulus (HP:0002580)2.98305337
7Abnormality of the labia minora (HP:0012880)2.94870899
8Glioma (HP:0009733)2.86291925
9Selective tooth agenesis (HP:0001592)2.72158653
10Missing ribs (HP:0000921)2.71177694
11Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.68255613
12Short 4th metacarpal (HP:0010044)2.68255613
13Increased nuchal translucency (HP:0010880)2.63474003
14Deviation of the thumb (HP:0009603)2.57767739
15Obsessive-compulsive behavior (HP:0000722)2.53992332
16Proximal placement of thumb (HP:0009623)2.52261715
17Neoplasm of the oral cavity (HP:0100649)2.51031458
18Renal duplication (HP:0000075)2.50252193
19Biliary tract neoplasm (HP:0100574)2.48423534
20Rhabdomyosarcoma (HP:0002859)2.38903137
21Chromsome breakage (HP:0040012)2.37023955
22Patellar aplasia (HP:0006443)2.35193411
23Malignant gastrointestinal tract tumors (HP:0006749)2.33028086
24Gastrointestinal carcinoma (HP:0002672)2.33028086
25Overriding aorta (HP:0002623)2.31307269
26Chromosomal breakage induced by crosslinking agents (HP:0003221)2.27467344
27Neoplasm of striated muscle (HP:0009728)2.25509484
28Insomnia (HP:0100785)2.25379711
29Aplasia/Hypoplasia of the sternum (HP:0006714)2.24762934
30Shawl scrotum (HP:0000049)2.22488465
31Ankyloglossia (HP:0010296)2.17478053
32Esophageal atresia (HP:0002032)2.17243356
33Aplasia/Hypoplasia of the patella (HP:0006498)2.16399981
34Agnosia (HP:0010524)2.16315744
35Hepatoblastoma (HP:0002884)2.16098877
36Hyperacusis (HP:0010780)2.15895527
37Abnormal number of incisors (HP:0011064)2.12414801
38Supernumerary ribs (HP:0005815)2.09107050
39Abnormality of the anterior horn cell (HP:0006802)2.05962029
40Degeneration of anterior horn cells (HP:0002398)2.05962029
41Duplication of thumb phalanx (HP:0009942)2.05599867
42Abnormal lung lobation (HP:0002101)2.04657087
43Rib fusion (HP:0000902)2.04252216
44Subacute progressive viral hepatitis (HP:0006572)2.03705167
45Abnormality of the calcaneus (HP:0008364)2.02540529
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.02402512
47Heterotopia (HP:0002282)2.00323959
48Spastic diplegia (HP:0001264)1.99835035
49Facial hemangioma (HP:0000329)1.99657647
50Broad thumb (HP:0011304)1.97799901
51Atresia of the external auditory canal (HP:0000413)1.97056488
52Meckel diverticulum (HP:0002245)1.96903573
53Nephroblastoma (Wilms tumor) (HP:0002667)1.96453286
54Facial cleft (HP:0002006)1.93802829
55Intestinal polyp (HP:0005266)1.93096080
56Birth length less than 3rd percentile (HP:0003561)1.92820944
57Abnormality of the 4th metacarpal (HP:0010012)1.92657563
58Supernumerary bones of the axial skeleton (HP:0009144)1.92553438
59Supernumerary spleens (HP:0009799)1.91883722
6011 pairs of ribs (HP:0000878)1.91323688
61Abnormality of abdominal situs (HP:0011620)1.91253137
62Abdominal situs inversus (HP:0003363)1.91253137
63Shallow orbits (HP:0000586)1.90797439
64Intestinal polyposis (HP:0200008)1.90199335
65Cutaneous syndactyly (HP:0012725)1.89447208
66Absent radius (HP:0003974)1.88998939
67Embryonal renal neoplasm (HP:0011794)1.88852859
68Abnormality of the ileum (HP:0001549)1.88561940
69Abnormality of chromosome stability (HP:0003220)1.88373356
70Impulsivity (HP:0100710)1.87772271
71Shoulder girdle muscle weakness (HP:0003547)1.87685176
72Aplasia/hypoplasia of the humerus (HP:0006507)1.87363448
73Basal cell carcinoma (HP:0002671)1.85939882
74Skull defect (HP:0001362)1.85590781
75Vertebral arch anomaly (HP:0008438)1.84887134
76Deep philtrum (HP:0002002)1.84827003
77Short humerus (HP:0005792)1.84557167
78Asymmetry of the thorax (HP:0001555)1.81299602
79Uterine leiomyosarcoma (HP:0002891)1.80712097
80Leiomyosarcoma (HP:0100243)1.80712097
81Rectal prolapse (HP:0002035)1.80333041
82Ectopic kidney (HP:0000086)1.79408199
83Abnormality of chromosome segregation (HP:0002916)1.79383344
84Cutaneous finger syndactyly (HP:0010554)1.79214452
85Renovascular hypertension (HP:0100817)1.78461780
86Turricephaly (HP:0000262)1.77705511
87Ovarian neoplasm (HP:0100615)1.77608124
88Thin ribs (HP:0000883)1.77026079
89High anterior hairline (HP:0009890)1.76705875
90Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.76257619
91Reticulocytopenia (HP:0001896)1.76158341
92Absent forearm bone (HP:0003953)1.76131800
93Aplasia involving forearm bones (HP:0009822)1.76131800
94Gastrointestinal atresia (HP:0002589)1.75319178
95Arnold-Chiari malformation (HP:0002308)1.75186225
96Abnormality of the carotid arteries (HP:0005344)1.75068803
97Back pain (HP:0003418)1.74809893
98Cafe-au-lait spot (HP:0000957)1.74022124
99Bowel diverticulosis (HP:0005222)1.73697148
100Cortical dysplasia (HP:0002539)1.73645619
101Uterine neoplasm (HP:0010784)1.73545524
102Abnormality of the lower motor neuron (HP:0002366)1.73479958
103Overlapping toe (HP:0001845)1.72571176
104Anal stenosis (HP:0002025)1.72556263
105Broad phalanges of the hand (HP:0009768)1.72003036
106Neoplasm of the pancreas (HP:0002894)1.71029814
107Myelodysplasia (HP:0002863)1.70064796
108Sandal gap (HP:0001852)1.69615845
109Elfin facies (HP:0004428)1.68454259
110Abnormality of the diencephalon (HP:0010662)1.68431930
111Pelvic girdle muscle weakness (HP:0003749)1.67498524
112Embryonal neoplasm (HP:0002898)1.67342946
113Adenoma sebaceum (HP:0009720)1.66925782
114Angiofibromas (HP:0010615)1.66925782
115Atrophy/Degeneration involving motor neurons (HP:0007373)1.66708401
116Trigonocephaly (HP:0000243)1.65985750
117Broad palm (HP:0001169)1.65959017
118Papillary thyroid carcinoma (HP:0002895)1.65811348
119Spina bifida occulta (HP:0003298)1.65582768
120Abnormality of cochlea (HP:0000375)1.65336981
121Spinal muscular atrophy (HP:0007269)1.65307431
122Choanal stenosis (HP:0000452)1.65284291
123Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.65061687
124Short 1st metacarpal (HP:0010034)1.65061687
125High pitched voice (HP:0001620)1.64945795
126Duodenal stenosis (HP:0100867)1.64669425
127Small intestinal stenosis (HP:0012848)1.64669425
128Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.64386023
129Partial duplication of thumb phalanx (HP:0009944)1.64096101
130Ulnar bowing (HP:0003031)1.63146905
131Deep palmar crease (HP:0006191)1.61994648
132Long eyelashes (HP:0000527)1.61506824
133Omphalocele (HP:0001539)1.61449528
134Hypospadias (HP:0000047)1.59947216
135Choanal atresia (HP:0000453)1.58424882
136Broad distal phalanx of finger (HP:0009836)1.58047226
137Abnormality of oral frenula (HP:0000190)1.57960004
138Generalized hypotonia (HP:0001290)1.57005338
139Broad finger (HP:0001500)1.56863182
140Termporal pattern (HP:0011008)1.56172423
141Insidious onset (HP:0003587)1.56172423
142Multiple enchondromatosis (HP:0005701)1.55811546
143Progressive external ophthalmoplegia (HP:0000590)1.55715791
144Abnormality of the salivary glands (HP:0010286)1.55201620
145Horseshoe kidney (HP:0000085)1.54022214
146Abnormality of the preputium (HP:0100587)1.53645304
147Coronal craniosynostosis (HP:0004440)1.51757627
148Pseudobulbar signs (HP:0002200)1.51316377

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.36055856
2CDC73.95893469
3PASK2.70661062
4EEF2K2.55029513
5WEE12.47893984
6NEK22.46720021
7MAP3K102.36860101
8SRPK12.29849249
9SMG12.26264098
10PNCK2.22011221
11TSSK62.17485436
12CAMK1G2.16409625
13EPHA22.13483313
14TTK2.03992424
15PBK1.97387961
16RPS6KB21.97064447
17PKN21.85660408
18TGFBR11.81017687
19VRK21.78572327
20PLK31.78229974
21MKNK11.76306931
22BUB11.73952659
23LATS11.72818327
24BRD41.66203126
25ALK1.63838022
26NEK11.63132291
27TAF11.60444127
28ATR1.57212557
29PLK11.54920610
30CDK71.53937591
31NTRK11.51418627
32CHEK11.47896417
33SCYL21.41927947
34MKNK21.35241354
35CHEK21.34157376
36CAMK1D1.31839809
37ERBB31.29252198
38ICK1.29076556
39PDGFRA1.28852571
40LATS21.28661311
41AURKB1.24701246
42MTOR1.24589820
43TYRO31.22952011
44DYRK31.22064407
45CDK61.20479335
46MARK11.20021799
47ATM1.18739656
48PAK41.14706677
49KSR11.14414942
50CDK21.13773758
51PRKD31.13522797
52CDK41.09435223
53STK31.09126055
54EPHB20.99590985
55MAP3K80.99056931
56TNIK0.97229615
57STK38L0.95147198
58CDK80.94812491
59MELK0.93465919
60MET0.88736487
61DYRK20.87634104
62CDK10.87425218
63FGFR10.86967856
64PTK60.84833229
65TLK10.83764175
66RPS6KA40.83239628
67TRIB30.81150941
68AURKA0.80723575
69STK100.79804940
70CSNK1D0.79251860
71ACVR1B0.79200905
72BRSK20.75953874
73MAP3K90.75675544
74CSNK1E0.74388440
75BRAF0.71452892
76PRKDC0.70924701
77CLK10.70646996
78CDK190.70026474
79DDR20.69510410
80STK40.67938829
81CDK11A0.66482456
82PIM10.64801545
83CDK150.64548811
84CDK180.62510542
85PAK20.62420800
86FGFR40.62383092
87DYRK1B0.61235654
88RIPK10.60589534
89MAPK140.60474980
90MAP3K40.58260377
91CDK90.57891431
92AKT30.57665549
93LRRK20.57162530
94VRK10.56853797
95CSNK2A20.55939804
96KSR20.55652264
97ERBB40.55545508
98CDK30.55519798
99NME10.55002273
100YES10.52750343
101GSK3B0.52001486
102BRSK10.51951334
103CASK0.50915464
104AKT10.49748938
105CDK140.49524962
106PRKCI0.49155204
107ZAK0.49038359
108PLK40.48789641
109PTK20.46300180
110BMX0.43713974
111AKT20.42439657
112MAPK10.42307482
113TTN0.41319879
114RPS6KA10.41305536
115STK240.41008801
116EIF2AK10.39788433
117EIF2AK20.39756807
118PDGFRB0.39407494
119RPS6KB10.38335700
120CHUK0.38100518
121MAPK90.37666102
122MAPK80.37624111
123MST1R0.37512797
124NME20.37208838
125MAPK100.36429812
126FGFR20.35414016
127BCR0.34662784
128CSNK1A1L0.34285227
129UHMK10.34135262

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.17836476
2DNA replication_Homo sapiens_hsa030303.12309656
3RNA transport_Homo sapiens_hsa030133.00085173
4Spliceosome_Homo sapiens_hsa030402.94314704
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.74976225
6mRNA surveillance pathway_Homo sapiens_hsa030152.57104990
7Cell cycle_Homo sapiens_hsa041102.53204330
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.25560072
9Base excision repair_Homo sapiens_hsa034102.09021538
10One carbon pool by folate_Homo sapiens_hsa006702.02966357
11Nucleotide excision repair_Homo sapiens_hsa034201.99324839
12Fanconi anemia pathway_Homo sapiens_hsa034601.85003756
13Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.76884596
14Non-homologous end-joining_Homo sapiens_hsa034501.73562615
15Biosynthesis of amino acids_Homo sapiens_hsa012301.69806293
16Hippo signaling pathway_Homo sapiens_hsa043901.66980770
17Basal cell carcinoma_Homo sapiens_hsa052171.66642915
18RNA degradation_Homo sapiens_hsa030181.61866635
19Homologous recombination_Homo sapiens_hsa034401.60139916
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.59799292
21MicroRNAs in cancer_Homo sapiens_hsa052061.51890220
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.48011877
23p53 signaling pathway_Homo sapiens_hsa041151.47495258
24Oocyte meiosis_Homo sapiens_hsa041141.43170976
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.42868314
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.41568476
27Colorectal cancer_Homo sapiens_hsa052101.40662638
28RNA polymerase_Homo sapiens_hsa030201.40383500
29Ribosome_Homo sapiens_hsa030101.39753395
30Adherens junction_Homo sapiens_hsa045201.39524895
31Hedgehog signaling pathway_Homo sapiens_hsa043401.32877105
32Viral carcinogenesis_Homo sapiens_hsa052031.32380005
33Basal transcription factors_Homo sapiens_hsa030221.31541425
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31488623
35TGF-beta signaling pathway_Homo sapiens_hsa043501.26307646
36Systemic lupus erythematosus_Homo sapiens_hsa053221.25907190
37Notch signaling pathway_Homo sapiens_hsa043301.25236178
38mTOR signaling pathway_Homo sapiens_hsa041501.22267713
39Chronic myeloid leukemia_Homo sapiens_hsa052201.16478521
40HTLV-I infection_Homo sapiens_hsa051661.15630673
41Wnt signaling pathway_Homo sapiens_hsa043101.13117961
42Endometrial cancer_Homo sapiens_hsa052131.13081165
43Small cell lung cancer_Homo sapiens_hsa052221.11785846
44Carbon metabolism_Homo sapiens_hsa012001.09357781
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.08864845
46Epstein-Barr virus infection_Homo sapiens_hsa051691.08366745
47Thyroid cancer_Homo sapiens_hsa052161.07014908
48Alcoholism_Homo sapiens_hsa050340.98712144
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96338778
50Tight junction_Homo sapiens_hsa045300.95734166
51Selenocompound metabolism_Homo sapiens_hsa004500.94610700
52Central carbon metabolism in cancer_Homo sapiens_hsa052300.92665228
53Pyrimidine metabolism_Homo sapiens_hsa002400.91831361
54Pentose phosphate pathway_Homo sapiens_hsa000300.91483882
55Proteoglycans in cancer_Homo sapiens_hsa052050.86527597
56Prostate cancer_Homo sapiens_hsa052150.85562228
57Bladder cancer_Homo sapiens_hsa052190.85081873
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84823336
59Pathways in cancer_Homo sapiens_hsa052000.84167454
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83790212
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82750850
62N-Glycan biosynthesis_Homo sapiens_hsa005100.82691157
63Herpes simplex infection_Homo sapiens_hsa051680.82076524
64Viral myocarditis_Homo sapiens_hsa054160.79224749
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77730258
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77620946
67Pyruvate metabolism_Homo sapiens_hsa006200.75431242
68Non-small cell lung cancer_Homo sapiens_hsa052230.73998120
69Antigen processing and presentation_Homo sapiens_hsa046120.73842085
70Steroid biosynthesis_Homo sapiens_hsa001000.71533591
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69181596
72Focal adhesion_Homo sapiens_hsa045100.68945407
73Renal cell carcinoma_Homo sapiens_hsa052110.67720860
74Pancreatic cancer_Homo sapiens_hsa052120.67071797
75Glioma_Homo sapiens_hsa052140.66305262
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66184023
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.65534827
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64913986
79Estrogen signaling pathway_Homo sapiens_hsa049150.64904314
80Dorso-ventral axis formation_Homo sapiens_hsa043200.64557804
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63606955
82Vitamin B6 metabolism_Homo sapiens_hsa007500.62991609
83FoxO signaling pathway_Homo sapiens_hsa040680.61041152
84Lysine degradation_Homo sapiens_hsa003100.60518752
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60515006
86Melanoma_Homo sapiens_hsa052180.59380246
87Axon guidance_Homo sapiens_hsa043600.59112247
88Proteasome_Homo sapiens_hsa030500.58447102
89Insulin signaling pathway_Homo sapiens_hsa049100.58400246
90HIF-1 signaling pathway_Homo sapiens_hsa040660.57825985
91Hepatitis B_Homo sapiens_hsa051610.56684306
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55530605
93Melanogenesis_Homo sapiens_hsa049160.55006146
94ErbB signaling pathway_Homo sapiens_hsa040120.53828711
95PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52768899
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50496948
97Acute myeloid leukemia_Homo sapiens_hsa052210.50296862
98Apoptosis_Homo sapiens_hsa042100.49080165
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48343527
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47966386
101ECM-receptor interaction_Homo sapiens_hsa045120.47128391
102Prolactin signaling pathway_Homo sapiens_hsa049170.46234407
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45643180
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45559544
105VEGF signaling pathway_Homo sapiens_hsa043700.45003427
106MAPK signaling pathway_Homo sapiens_hsa040100.42513918
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42245240
108Rap1 signaling pathway_Homo sapiens_hsa040150.42162836
109Purine metabolism_Homo sapiens_hsa002300.41534374
110Gap junction_Homo sapiens_hsa045400.39450739
111Legionellosis_Homo sapiens_hsa051340.39201063
112Folate biosynthesis_Homo sapiens_hsa007900.38590330
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38039895
114Shigellosis_Homo sapiens_hsa051310.38013119
115Galactose metabolism_Homo sapiens_hsa000520.37215567
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.36703256
117Fructose and mannose metabolism_Homo sapiens_hsa000510.36472137
118Inositol phosphate metabolism_Homo sapiens_hsa005620.35280017
119Influenza A_Homo sapiens_hsa051640.35125947
120Type II diabetes mellitus_Homo sapiens_hsa049300.35060743
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34982010
122AMPK signaling pathway_Homo sapiens_hsa041520.34578199
123T cell receptor signaling pathway_Homo sapiens_hsa046600.33554464
124NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32345336
125Toxoplasmosis_Homo sapiens_hsa051450.31105929

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