KDM1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (Karytinos et al., 2009 [PubMed 19407342]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.05674966
2L-phenylalanine catabolic process (GO:0006559)6.05674966
3piRNA metabolic process (GO:0034587)5.99463551
4L-phenylalanine metabolic process (GO:0006558)5.75151425
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.75151425
6aromatic amino acid family catabolic process (GO:0009074)5.25302868
7cysteine metabolic process (GO:0006534)5.17275739
8positive regulation of gamma-delta T cell activation (GO:0046645)5.04041701
9bile acid biosynthetic process (GO:0006699)5.03191926
10urate metabolic process (GO:0046415)4.92531655
11urea metabolic process (GO:0019627)4.82940266
12urea cycle (GO:0000050)4.82940266
13response to peptidoglycan (GO:0032494)4.79837176
14phospholipid homeostasis (GO:0055091)4.64601435
15alpha-linolenic acid metabolic process (GO:0036109)4.63760591
16indole-containing compound catabolic process (GO:0042436)4.63129377
17indolalkylamine catabolic process (GO:0046218)4.63129377
18tryptophan catabolic process (GO:0006569)4.63129377
19kynurenine metabolic process (GO:0070189)4.62404484
20lysine metabolic process (GO:0006553)4.60972573
21lysine catabolic process (GO:0006554)4.60972573
22glyoxylate metabolic process (GO:0046487)4.58465875
23regulation of female gonad development (GO:2000194)4.58139339
24positive regulation by organism of defense response of other organism involved in symbiotic interact4.58050102
25modulation by symbiont of host immune response (GO:0052553)4.58050102
26positive regulation by symbiont of host defense response (GO:0052509)4.58050102
27modulation by symbiont of host defense response (GO:0052031)4.58050102
28modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.58050102
29modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.58050102
30tryptophan metabolic process (GO:0006568)4.53585092
31triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.41212483
32neutrophil activation involved in immune response (GO:0002283)4.39518355
33* DNA methylation involved in gamete generation (GO:0043046)4.38430918
34sulfur amino acid catabolic process (GO:0000098)4.35189739
35serine family amino acid catabolic process (GO:0009071)4.34072800
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.29832916
37nitrogen cycle metabolic process (GO:0071941)4.29463383
38bile acid metabolic process (GO:0008206)4.15100126
39positive regulation of humoral immune response (GO:0002922)4.14491805
40negative regulation of erythrocyte differentiation (GO:0045647)4.11667855
41regulation of cholesterol biosynthetic process (GO:0045540)4.11104645
42detection of other organism (GO:0098543)4.10759239
43negative regulation of fibrinolysis (GO:0051918)4.05887089
44cellular extravasation (GO:0045123)4.03562089
45high-density lipoprotein particle remodeling (GO:0034375)4.03222755
46peptidyl-glutamic acid carboxylation (GO:0017187)4.00147319
47protein carboxylation (GO:0018214)4.00147319
48homocysteine metabolic process (GO:0050667)3.97702273
49detection of molecule of bacterial origin (GO:0032490)3.96776247
50macrophage activation involved in immune response (GO:0002281)3.94615062
51immunoglobulin mediated immune response (GO:0016064)3.89458140
52positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.86891946
53glycine metabolic process (GO:0006544)3.85707946
54regulation of acrosome reaction (GO:0060046)3.83408741
55complement activation, alternative pathway (GO:0006957)3.83279294
56regulation of protein activation cascade (GO:2000257)3.79351691
57serine family amino acid metabolic process (GO:0009069)3.75237505
58detection of bacterium (GO:0016045)3.73520913
59regulation of gamma-delta T cell activation (GO:0046643)3.73464535
60negative regulation of cholesterol transport (GO:0032375)3.70698969
61negative regulation of sterol transport (GO:0032372)3.70698969
62alpha-amino acid catabolic process (GO:1901606)3.69663697
63aromatic amino acid family metabolic process (GO:0009072)3.67995145
64cellular modified amino acid catabolic process (GO:0042219)3.67536181
65histone H3-K36 demethylation (GO:0070544)3.67103740
66nuclear pore complex assembly (GO:0051292)3.66351247
67response to muramyl dipeptide (GO:0032495)3.65684935
68oocyte development (GO:0048599)3.64579021
69protein kinase C signaling (GO:0070528)3.62676228
70detection of external biotic stimulus (GO:0098581)3.61139883
71amino-acid betaine metabolic process (GO:0006577)3.60095800
72serine family amino acid biosynthetic process (GO:0009070)3.59738353
73regulation of fibrinolysis (GO:0051917)3.59514179
74negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.58763239
75negative regulation of cell killing (GO:0031342)3.58763239
76ethanol oxidation (GO:0006069)3.56145821
77valine metabolic process (GO:0006573)3.54288521
78regulation of complement activation (GO:0030449)3.52247668
79reverse cholesterol transport (GO:0043691)3.51200516
80cellular ketone body metabolic process (GO:0046950)3.49625344
81response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.48019208
82response to host immune response (GO:0052572)3.48019208
83regulation of hypersensitivity (GO:0002883)3.44420448
84cellular amino acid catabolic process (GO:0009063)3.43583106
85regulation of mast cell degranulation (GO:0043304)3.43475551
86positive regulation of cellular amide metabolic process (GO:0034250)3.41039976
87regulation of cholesterol metabolic process (GO:0090181)3.40588837
88regulation of triglyceride catabolic process (GO:0010896)3.40060415
89phospholipid efflux (GO:0033700)3.39838801
90response to host (GO:0075136)3.39210138
91response to host defenses (GO:0052200)3.39210138
92response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.39210138
93bile acid and bile salt transport (GO:0015721)3.38607983
94intestinal cholesterol absorption (GO:0030299)3.36670993
95negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.36601840
96regulation of leukocyte degranulation (GO:0043300)3.35714051
97regulation of B cell receptor signaling pathway (GO:0050855)3.34272255
98antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.33929365
99regulation of gamma-delta T cell differentiation (GO:0045586)3.32086360
100positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.30418793
101regulation of interferon-beta biosynthetic process (GO:0045357)3.30140590
102tyrosine metabolic process (GO:0006570)3.29413134
103neutrophil mediated immunity (GO:0002446)3.28607774
104indolalkylamine metabolic process (GO:0006586)3.26790237
105nuclear pore organization (GO:0006999)3.26668155
106macromolecular complex remodeling (GO:0034367)3.25937535
107plasma lipoprotein particle remodeling (GO:0034369)3.25937535
108protein-lipid complex remodeling (GO:0034368)3.25937535
109drug catabolic process (GO:0042737)3.25579841
110citrulline biosynthetic process (GO:0019240)3.25072294
111acylglycerol homeostasis (GO:0055090)3.23946211
112triglyceride homeostasis (GO:0070328)3.23946211
113hypotonic response (GO:0006971)3.23097143
114histone H3-K9 demethylation (GO:0033169)3.21510607
115regulation of myeloid leukocyte mediated immunity (GO:0002886)3.20593905
116plasma lipoprotein particle clearance (GO:0034381)3.19763889
117B cell receptor signaling pathway (GO:0050853)3.17686411
118regulation of mast cell activation involved in immune response (GO:0033006)3.17588893
119regulation of bile acid biosynthetic process (GO:0070857)3.15784061
120dicarboxylic acid biosynthetic process (GO:0043650)3.15068190
121gene silencing by RNA (GO:0031047)3.14790114
122regulation of RNA export from nucleus (GO:0046831)3.12759166
123glutamate metabolic process (GO:0006536)3.12066175
124aspartate family amino acid catabolic process (GO:0009068)3.10603912
125cholesterol homeostasis (GO:0042632)3.10358249
126acetyl-CoA metabolic process (GO:0006084)3.10325906
127fatty acid oxidation (GO:0019395)3.10293624
128sterol homeostasis (GO:0055092)3.09904075
129detection of biotic stimulus (GO:0009595)3.09862233
130short-chain fatty acid metabolic process (GO:0046459)3.09468129
131fatty acid beta-oxidation (GO:0006635)3.09161388
132negative regulation of interleukin-12 production (GO:0032695)3.08565173
133coenzyme catabolic process (GO:0009109)3.06625352
134fatty acid homeostasis (GO:0055089)3.05631431
135B cell mediated immunity (GO:0019724)3.05418632
136cholesterol efflux (GO:0033344)3.04984812
137microglial cell activation (GO:0001774)3.04515228
138positive regulation of mast cell activation (GO:0033005)3.04230788
139regulation of cholesterol esterification (GO:0010872)3.03963594
140* DNA alkylation (GO:0006305)3.03705169
141* DNA methylation (GO:0006306)3.03705169
142male meiosis (GO:0007140)3.03408392
143neutrophil activation (GO:0042119)3.03190458
144macrophage activation (GO:0042116)3.02112967
145regulation of cholesterol homeostasis (GO:2000188)3.01951866
146lipid oxidation (GO:0034440)3.00908456
147growth hormone receptor signaling pathway (GO:0060396)3.00115414
148benzene-containing compound metabolic process (GO:0042537)2.99077860
149carboxylic acid catabolic process (GO:0046395)2.98988826
150organic acid catabolic process (GO:0016054)2.98988826
151one-carbon metabolic process (GO:0006730)2.98947462
152mitotic chromosome condensation (GO:0007076)2.97596128
153fibrinolysis (GO:0042730)2.96909210
154N-terminal protein amino acid acetylation (GO:0006474)2.96329785
155ketone body metabolic process (GO:1902224)2.95350566
1562-oxoglutarate metabolic process (GO:0006103)2.94701704
157positive regulation of leukocyte degranulation (GO:0043302)2.94201296
158positive regulation of B cell differentiation (GO:0045579)2.93620594
159germinal center formation (GO:0002467)2.93495773
160imidazole-containing compound metabolic process (GO:0052803)2.91892164
161regulation of fatty acid beta-oxidation (GO:0031998)2.91598387
162positive regulation of mast cell degranulation (GO:0043306)2.91009442
163positive regulation of mast cell activation involved in immune response (GO:0033008)2.91009442
164cytolysis (GO:0019835)2.90470266
165drug transmembrane transport (GO:0006855)2.90090008
166lipopolysaccharide-mediated signaling pathway (GO:0031663)2.90007950
167antigen processing and presentation of endogenous antigen (GO:0019883)2.87874000
168regulation of nucleobase-containing compound transport (GO:0032239)2.86292133
169negative regulation of histone methylation (GO:0031061)2.79728931
170histone H3-K4 trimethylation (GO:0080182)2.77774042
171dosage compensation (GO:0007549)2.77277519
172regulation of histone H3-K9 methylation (GO:0051570)2.76571469
173negative regulation of lymphocyte mediated immunity (GO:0002707)2.76229617
174regulation of regulated secretory pathway (GO:1903305)2.75894527
175antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.75202090
176granulocyte activation (GO:0036230)2.74470031
177myeloid cell activation involved in immune response (GO:0002275)2.73172208
178pore complex assembly (GO:0046931)2.70607931
179definitive hemopoiesis (GO:0060216)2.65121374
180leukocyte aggregation (GO:0070486)2.63778624
181positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.62700992
182regulation of cellular amide metabolic process (GO:0034248)2.61325847
183negative regulation of T cell mediated immunity (GO:0002710)2.60472374
184regulation of mast cell activation (GO:0033003)2.60196902
185multicellular organism reproduction (GO:0032504)2.59584224
186myeloid leukocyte mediated immunity (GO:0002444)2.56869462
187positive regulation of Cdc42 GTPase activity (GO:0043089)2.56772351
188production of molecular mediator involved in inflammatory response (GO:0002532)2.56277526
189positive regulation of regulated secretory pathway (GO:1903307)2.55839485
190respiratory burst (GO:0045730)2.51451450
191antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.50342979
192histone H3-K4 methylation (GO:0051568)2.50038091
193phosphatidylinositol dephosphorylation (GO:0046856)2.48145100
194regulation of amyloid precursor protein catabolic process (GO:1902991)2.46762551
195regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.46745659
196phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.44436375
197negative regulation of toll-like receptor signaling pathway (GO:0034122)2.43266253
198* histone lysine demethylation (GO:0070076)2.42021030
199peptidyl-threonine phosphorylation (GO:0018107)2.39057166
200leukocyte migration involved in inflammatory response (GO:0002523)2.38833244

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.07866585
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.81614345
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.31190999
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.03936621
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.78377781
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.21034951
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.14617152
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.03971631
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.01361733
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.90041529
11VDR_21846776_ChIP-Seq_THP-1_Human2.78617894
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.78304723
13* CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.72532563
14EZH2_22144423_ChIP-Seq_EOC_Human2.70898489
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.66640230
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.64360756
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.58273685
18SPI1_23127762_ChIP-Seq_K562_Human2.55277785
19VDR_24763502_ChIP-Seq_THP-1_Human2.48972583
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.41371957
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.34454110
22AR_21909140_ChIP-Seq_LNCAP_Human2.29756774
23E2F7_22180533_ChIP-Seq_HELA_Human2.27584993
24GATA1_22025678_ChIP-Seq_K562_Human2.23784285
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.18801284
26SPI1_23547873_ChIP-Seq_NB4_Human2.12644274
27RUNX1_22412390_ChIP-Seq_EML_Mouse2.02677625
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.98008546
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96311422
30CLOCK_20551151_ChIP-Seq_293T_Human1.82923873
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.80365282
32FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.75163819
33FOXA2_19822575_ChIP-Seq_HepG2_Human1.74192200
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.72968097
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.71913318
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.69700038
37GATA1_19941826_ChIP-Seq_K562_Human1.67256882
38GATA1_19941827_ChIP-Seq_MEL_Mouse1.63961477
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.57894350
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.54416872
41* KDM2B_26808549_Chip-Seq_DND41_Human1.54296206
42* NCOR1_26117541_ChIP-Seq_K562_Human1.52211450
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.50865361
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.50592534
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.49030442
46SOX2_27498859_Chip-Seq_STOMACH_Mouse1.48290640
47GATA1_22383799_ChIP-Seq_G1ME_Mouse1.48158072
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.46711597
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.46119693
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.44089812
51VDR_24787735_ChIP-Seq_THP-1_Human1.42141606
52GATA6_25053715_ChIP-Seq_YYC3_Human1.41449772
53HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.40314798
54FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.39576940
55MYC_22102868_ChIP-Seq_BL_Human1.36608328
56PU_27001747_Chip-Seq_BMDM_Mouse1.35941456
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.35381352
58HNF4A_19822575_ChIP-Seq_HepG2_Human1.33316291
59FOXM1_23109430_ChIP-Seq_U2OS_Human1.29752130
60TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.28902348
61TFEB_21752829_ChIP-Seq_HELA_Human1.28165482
62FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.27596614
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.25663778
64FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21605299
65GATA1_19941827_ChIP-Seq_MEL86_Mouse1.21268838
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.18598362
67FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.17291136
68MAF_26560356_Chip-Seq_TH2_Human1.16853247
69ESR1_21235772_ChIP-Seq_MCF-7_Human1.16397160
70KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14006216
71KDM2B_26808549_Chip-Seq_JURKAT_Human1.13026923
72GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12015517
73* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11162709
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10639502
75KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10559840
76GATA4_25053715_ChIP-Seq_YYC3_Human1.09522061
77ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09179119
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06536286
79KDM5A_27292631_Chip-Seq_BREAST_Human1.04648597
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04553949
81CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03521278
82GATA3_27048872_Chip-Seq_THYMUS_Human1.03227045
83MYB_26560356_Chip-Seq_TH1_Human1.02160373
84CHD1_26751641_Chip-Seq_LNCaP_Human1.01836573
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01386511
86PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00939696
87RUNX_20019798_ChIP-Seq_JUKART_Human1.00482651
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99548775
89STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.99401449
90* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99150196
91AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99078003
92MAF_26560356_Chip-Seq_TH1_Human0.98179140
93CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98045340
94SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96623871
95CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96221885
96PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95698776
97KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95250305
98SALL1_21062744_ChIP-ChIP_HESCs_Human0.94991858
99FOXA1_25552417_ChIP-Seq_VCAP_Human0.94356597
100RACK7_27058665_Chip-Seq_MCF-7_Human0.94044592
101E2F1_21310950_ChIP-Seq_MCF-7_Human0.94017647
102* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93834991
103TCF7_22412390_ChIP-Seq_EML_Mouse0.93503007
104TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92746081
105SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92724706
106KDM2B_26808549_Chip-Seq_K562_Human0.92640483
107SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92387106
108SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92387106
109ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92286159
110STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90908678
111GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90048188
112SCL_19346495_ChIP-Seq_HPC-7_Human0.89415392
113FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.89258380
114PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88976197
115FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.88487840
116RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.86674652
117SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86258693
118TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.84834170
119* CDX2_22108803_ChIP-Seq_LS180_Human0.83590985
120ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.83525773
121MYB_21317192_ChIP-Seq_ERMYB_Mouse0.82059630
122BRD4_27068464_Chip-Seq_AML-cells_Mouse0.81864022
123STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79306163
124TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.79117649
125MYB_26560356_Chip-Seq_TH2_Human0.77561136
126GATA2_22383799_ChIP-Seq_G1ME_Mouse0.76049508
127PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75898733
128KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75264483
129NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.74242772
130SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73507853
131RXRA_24833708_ChIP-Seq_LIVER_Mouse0.72692727
132GATA2_19941826_ChIP-Seq_K562_Human0.72477478
133TBX20_22328084_ChIP-Seq_HEART_Mouse0.71879199
134TBX20_22080862_ChIP-Seq_HEART_Mouse0.71879199
135FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.70707558
136TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.70637033
137GATA3_26560356_Chip-Seq_TH2_Human0.70169958
138GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.70166757
139UTX_26944678_Chip-Seq_JUKART_Human0.69658052
140* CEBPB_22108803_ChIP-Seq_LS180_Human0.68782465
141P300_27058665_Chip-Seq_ZR-75-30cells_Human0.68480331
142GATA2_21666600_ChIP-Seq_HMVEC_Human0.68416921
143GATA3_24758297_ChIP-Seq_MCF-7_Human0.68416351
144KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.67671121
145E2F4_17652178_ChIP-ChIP_JURKAT_Human0.66736550
146IRF8_27001747_Chip-Seq_BMDM_Mouse0.65612522
147STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.65602042
148ATF3_27146783_Chip-Seq_COLON_Human0.65263628
149HNFA_21074721_ChIP-Seq_CACO-2_Human0.64309444
150SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.64006132
151HTT_18923047_ChIP-ChIP_STHdh_Human0.62974963
152NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.61706339

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.91083019
2MP0002139_abnormal_hepatobiliary_system5.83310338
3MP0005365_abnormal_bile_salt4.71120167
4MP0005085_abnormal_gallbladder_physiolo4.19630370
5MP0003303_peritoneal_inflammation3.15515197
6MP0008875_abnormal_xenobiotic_pharmacok3.07432466
7MP0003436_decreased_susceptibility_to3.00944297
8MP0003252_abnormal_bile_duct2.95808660
9MP0003806_abnormal_nucleotide_metabolis2.82703203
10MP0004510_myositis2.74254140
11MP0008877_abnormal_DNA_methylation2.72633678
12MP0001666_abnormal_nutrient_absorption2.52225923
13MP0003724_increased_susceptibility_to2.48303397
14MP0008260_abnormal_autophagy2.44374573
15MP0008057_abnormal_DNA_replication2.39032554
16MP0000569_abnormal_digit_pigmentation2.38970449
17MP0002419_abnormal_innate_immunity2.32835264
18MP0002396_abnormal_hematopoietic_system2.29311446
19MP0002138_abnormal_hepatobiliary_system2.28532175
20MP0009697_abnormal_copulation2.24954315
21MP0009840_abnormal_foam_cell2.20396837
22MP0010234_abnormal_vibrissa_follicle2.17685677
23MP0002254_reproductive_system_inflammat2.16912770
24MP0010329_abnormal_lipoprotein_level2.13615960
25MP0003183_abnormal_peptide_metabolism2.07512964
26MP0003172_abnormal_lysosome_physiology2.05933466
27MP0002166_altered_tumor_susceptibility2.03625159
28MP0005076_abnormal_cell_differentiation2.03077467
29MP0005083_abnormal_biliary_tract1.98804121
30MP0005451_abnormal_body_composition1.92597926
31MP0005025_abnormal_response_to1.90528142
32MP0005408_hypopigmentation1.88466876
33MP0005332_abnormal_amino_acid1.87943768
34MP0003828_pulmonary_edema1.87506656
35MP0003705_abnormal_hypodermis_morpholog1.84627506
36MP0005409_darkened_coat_color1.80047582
37MP0000609_abnormal_liver_physiology1.79149608
38MP0002452_abnormal_antigen_presenting1.78905676
39MP0005000_abnormal_immune_tolerance1.78065025
40MP0002420_abnormal_adaptive_immunity1.73713155
41MP0001819_abnormal_immune_cell1.70583083
42MP0002723_abnormal_immune_serum1.69219773
43MP0005397_hematopoietic_system_phenotyp1.68884107
44MP0001545_abnormal_hematopoietic_system1.68884107
45MP0002132_abnormal_respiratory_system1.66734666
46MP0003868_abnormal_feces_composition1.64707568
47MP0002398_abnormal_bone_marrow1.62639069
48MP0001790_abnormal_immune_system1.55847837
49MP0005387_immune_system_phenotype1.55847837
50MP0009278_abnormal_bone_marrow1.50527422
51MP0003191_abnormal_cellular_cholesterol1.49198759
52MP0002405_respiratory_system_inflammati1.40662522
53MP0010307_abnormal_tumor_latency1.40589484
54MP0002006_tumorigenesis1.39895825
55MP0009785_altered_susceptibility_to1.39381660
56MP0000858_altered_metastatic_potential1.39026599
57MP0003091_abnormal_cell_migration1.37153308
58MP0000716_abnormal_immune_system1.36203703
59MP0006082_CNS_inflammation1.34661123
60MP0002722_abnormal_immune_system1.30177499
61MP0002118_abnormal_lipid_homeostasis1.29076517
62MP0001873_stomach_inflammation1.27266842
63MP0003300_gastrointestinal_ulcer1.25912722
64MP0003566_abnormal_cell_adhesion1.23457815
65MP0003890_abnormal_embryonic-extraembry1.20459629
66MP0000685_abnormal_immune_system1.20297615
67MP0000689_abnormal_spleen_morphology1.18515377
68MP0000703_abnormal_thymus_morphology1.17525601
69MP0009643_abnormal_urine_homeostasis1.16709252
70MP0003195_calcinosis1.16026007
71MP0002429_abnormal_blood_cell1.15652084
72MP0000015_abnormal_ear_pigmentation1.14412169
73MP0000427_abnormal_hair_cycle1.13845307
74MP0005621_abnormal_cell_physiology1.13819670
75MP0003453_abnormal_keratinocyte_physiol1.13608191
76MP0004019_abnormal_vitamin_homeostasis1.11916268
77MP0003221_abnormal_cardiomyocyte_apopto1.11131818
78MP0001533_abnormal_skeleton_physiology1.10580111
79MP0006292_abnormal_olfactory_placode1.09720084
80MP0005220_abnormal_exocrine_pancreas1.08728867
81MP0002148_abnormal_hypersensitivity_rea1.08338317
82MP0004233_abnormal_muscle_weight1.07558881
83MP0005319_abnormal_enzyme/_coenzyme1.07265530
84MP0000598_abnormal_liver_morphology1.05935589
85MP0001851_eye_inflammation1.04744719
86MP0001346_abnormal_lacrimal_gland1.02833132
87MP0004264_abnormal_extraembryonic_tissu1.02332646
88MP0001835_abnormal_antigen_presentation1.02267354
89MP0010678_abnormal_skin_adnexa1.01030602
90MP0003656_abnormal_erythrocyte_physiolo1.00998742
91MP0004883_abnormal_blood_vessel0.99585319
92MP0002009_preneoplasia0.98724411
93MP0010352_gastrointestinal_tract_polyps0.98390417
94MP0005647_abnormal_sex_gland0.98112169
95MP0003123_paternal_imprinting0.93441764
96MP0005671_abnormal_response_to0.93054685
97MP0005164_abnormal_response_to0.92912323
98MP0001764_abnormal_homeostasis0.91295525
99MP0004947_skin_inflammation0.88849486
100* MP0003718_maternal_effect0.87437186
101* MP0003699_abnormal_female_reproductive0.86246726
102MP0001853_heart_inflammation0.85444543
103MP0005384_cellular_phenotype0.84865022
104MP0003011_delayed_dark_adaptation0.84529755
105MP0003075_altered_response_to0.83923064
106MP0001915_intracranial_hemorrhage0.83417874
107MP0003690_abnormal_glial_cell0.83167892
108MP0003763_abnormal_thymus_physiology0.81771883
109MP0009763_increased_sensitivity_to0.81346280
110MP0000350_abnormal_cell_proliferation0.80926690
111MP0004185_abnormal_adipocyte_glucose0.80657604
112MP0003077_abnormal_cell_cycle0.80224040
113MP0009333_abnormal_splenocyte_physiolog0.78694704
114MP0000377_abnormal_hair_follicle0.78542281
115MP0001919_abnormal_reproductive_system0.77863238
116MP0005584_abnormal_enzyme/coenzyme_acti0.77828574
117MP0009115_abnormal_fat_cell0.77500708
118MP0000579_abnormal_nail_morphology0.77400663
119MP0001800_abnormal_humoral_immune0.77184183
120MP0002019_abnormal_tumor_incidence0.76460729
121MP0000653_abnormal_sex_gland0.76367775
122MP0001243_abnormal_dermal_layer0.75661023
123MP0001119_abnormal_female_reproductive0.75564654
124MP0005501_abnormal_skin_physiology0.75218893
125MP0003448_altered_tumor_morphology0.75012989
126MP0001929_abnormal_gametogenesis0.74863356
127MP0003866_abnormal_defecation0.73697444
128MP0002998_abnormal_bone_remodeling0.73500884
129MP0002210_abnormal_sex_determination0.72185463
130MP0000678_abnormal_parathyroid_gland0.71960490
131MP0009765_abnormal_xenobiotic_induced0.71921538
132MP0005166_decreased_susceptibility_to0.71866144
133MP0001661_extended_life_span0.71002149
134MP0010094_abnormal_chromosome_stability0.70828236
135MP0001216_abnormal_epidermal_layer0.70486139
136MP0003329_amyloid_beta_deposits0.70179571
137MP0009384_cardiac_valve_regurgitation0.69484789
138MP0000465_gastrointestinal_hemorrhage0.68472081
139MP0002877_abnormal_melanocyte_morpholog0.68314545
140MP0009764_decreased_sensitivity_to0.67458380
141MP0004381_abnormal_hair_follicle0.65447758
142MP0000604_amyloidosis0.64844155
143MP0010155_abnormal_intestine_physiology0.63462862
144MP0001730_embryonic_growth_arrest0.63302700
145MP0000383_abnormal_hair_follicle0.62891912
146MP0002796_impaired_skin_barrier0.61397458
147MP0005310_abnormal_salivary_gland0.61335421
148MP0001145_abnormal_male_reproductive0.59765311
149MP0002136_abnormal_kidney_physiology0.59551269
150MP0002098_abnormal_vibrissa_morphology0.58768270
151* MP0005395_other_phenotype0.58733034
152MP0008469_abnormal_protein_level0.58431221
153MP0005666_abnormal_adipose_tissue0.55076694
154MP0005187_abnormal_penis_morphology0.54551552
155MP0005058_abnormal_lysosome_morphology0.54265943
156MP0002060_abnormal_skin_morphology0.54135309
157MP0002928_abnormal_bile_duct0.53850140
158MP0001845_abnormal_inflammatory_respons0.52808009
159MP0004808_abnormal_hematopoietic_stem0.52794106
160MP0002971_abnormal_brown_adipose0.52642177
161MP0005464_abnormal_platelet_physiology0.52638799
162MP0005023_abnormal_wound_healing0.50847089
163MP0001756_abnormal_urination0.50722252
164MP0000767_abnormal_smooth_muscle0.50504711

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.18782578
2Intrahepatic cholestasis (HP:0001406)6.09356041
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.58006357
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.42667702
5Hypobetalipoproteinemia (HP:0003563)4.99445911
6Recurrent bacterial skin infections (HP:0005406)4.81325577
7Xanthomatosis (HP:0000991)4.59835700
8Eczematoid dermatitis (HP:0000976)4.54484228
9Recurrent abscess formation (HP:0002722)4.46673896
10Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.06956511
11Abnormality of macrophages (HP:0004311)4.06195588
12Fat malabsorption (HP:0002630)3.88528717
13Hyperammonemia (HP:0001987)3.84261984
14Abnormality of sulfur amino acid metabolism (HP:0004339)3.84051354
15Complement deficiency (HP:0004431)3.78782910
16Abnormality of the common coagulation pathway (HP:0010990)3.77813105
17Hypolipoproteinemia (HP:0010981)3.68586696
18Prolonged partial thromboplastin time (HP:0003645)3.64598217
19Abnormality of glutamine family amino acid metabolism (HP:0010902)3.54724274
20Abnormality of aspartate family amino acid metabolism (HP:0010899)3.51466580
21Hypoglycemic coma (HP:0001325)3.46029285
22Epidermoid cyst (HP:0200040)3.43277152
23Hyperlipoproteinemia (HP:0010980)3.40425334
24Ketosis (HP:0001946)3.40318206
25Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.39211360
26Abnormality of fatty-acid metabolism (HP:0004359)3.39151796
27Abnormality of methionine metabolism (HP:0010901)3.33107840
28Cortical dysplasia (HP:0002539)3.23954992
29Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.22506769
30Abnormality of the fingertips (HP:0001211)3.18040669
31Hyperglycinuria (HP:0003108)3.16931457
32Recurrent gram-negative bacterial infections (HP:0005420)3.15545125
33Abnormality of pyrimidine metabolism (HP:0004353)3.14224136
34Hyperglycinemia (HP:0002154)3.12574767
35Hypoalphalipoproteinemia (HP:0003233)3.11537639
36Steatorrhea (HP:0002570)3.10426089
37Abnormality of glycine metabolism (HP:0010895)3.09003252
38Abnormality of serine family amino acid metabolism (HP:0010894)3.09003252
39Gingivitis (HP:0000230)3.08672339
40Joint hemorrhage (HP:0005261)3.00875735
41Hepatocellular carcinoma (HP:0001402)3.00433660
42Myositis (HP:0100614)2.99640547
43Myocardial infarction (HP:0001658)2.96500887
44Spastic diplegia (HP:0001264)2.91598950
45Abnormality of the intrinsic pathway (HP:0010989)2.87219632
46Subacute progressive viral hepatitis (HP:0006572)2.80493731
47Recurrent skin infections (HP:0001581)2.79993272
48Abnormality of nucleobase metabolism (HP:0010932)2.79695387
49Malnutrition (HP:0004395)2.75665601
50Recurrent fungal infections (HP:0002841)2.71334707
51Obstructive lung disease (HP:0006536)2.71069068
52Chronic obstructive pulmonary disease (HP:0006510)2.71069068
53Hypochromic microcytic anemia (HP:0004840)2.65577892
54Gastrointestinal infarctions (HP:0005244)2.63827671
55Orchitis (HP:0100796)2.63382701
56Viral hepatitis (HP:0006562)2.63096758
57Esophageal varix (HP:0002040)2.62462918
58Abnormality of purine metabolism (HP:0004352)2.62431012
59Conjugated hyperbilirubinemia (HP:0002908)2.59898635
60Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.55476365
61Urticaria (HP:0001025)2.54742791
62Cellulitis (HP:0100658)2.53215612
63Optic neuritis (HP:0100653)2.53067893
64Retrobulbar optic neuritis (HP:0100654)2.53067893
65Osteomyelitis (HP:0002754)2.52549254
66Hypercholesterolemia (HP:0003124)2.51380865
67Gingival bleeding (HP:0000225)2.51321783
68Abnormality of the musculature of the pelvis (HP:0001469)2.51244146
69Abnormality of the hip-girdle musculature (HP:0001445)2.51244146
70Spontaneous hematomas (HP:0007420)2.51065097
71Increased IgE level (HP:0003212)2.48369642
72Loss of speech (HP:0002371)2.47083572
73Gout (HP:0001997)2.43414702
74Limb-girdle muscle atrophy (HP:0003797)2.43238144
75Acute myeloid leukemia (HP:0004808)2.43224094
76Mediastinal lymphadenopathy (HP:0100721)2.42797205
77Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.42358470
78Abnormality of complement system (HP:0005339)2.39990165
79Lip pit (HP:0100267)2.37680870
80Recurrent viral infections (HP:0004429)2.36135485
81Polycythemia (HP:0001901)2.36065962
82Fatigue (HP:0012378)2.35725855
83Flat acetabular roof (HP:0003180)2.35650593
84Hemorrhage of the eye (HP:0011885)2.34465267
85Prolonged bleeding time (HP:0003010)2.32264663
86Abnormality of serum amino acid levels (HP:0003112)2.31482585
87Gastrointestinal inflammation (HP:0004386)2.31074073
88Meningitis (HP:0001287)2.30952476
89Spontaneous abortion (HP:0005268)2.28233641
90Chronic mucocutaneous candidiasis (HP:0002728)2.26899187
91Recurrent cutaneous fungal infections (HP:0011370)2.26899187
92Cholecystitis (HP:0001082)2.24319586
93Abnormal gallbladder physiology (HP:0012438)2.24319586
94Inflammation of the large intestine (HP:0002037)2.23898014
95Dysmetric saccades (HP:0000641)2.23571727
96Fair hair (HP:0002286)2.23229800
97Hyperbilirubinemia (HP:0002904)2.22524948
98Ketoacidosis (HP:0001993)2.20302171
99Thyroid carcinoma (HP:0002890)2.16917045
100Chest pain (HP:0100749)2.13214645
101Azoospermia (HP:0000027)2.12205587
102Periodontitis (HP:0000704)2.12169807
103Arterial thrombosis (HP:0004420)2.11432203
104Delayed CNS myelination (HP:0002188)2.10194847
105Truncal obesity (HP:0001956)2.09900632
106Ankyloglossia (HP:0010296)2.08630297
107Vasculitis (HP:0002633)2.08179724
108Amyloidosis (HP:0011034)2.05736596
109Skin nodule (HP:0200036)2.05018615
110Increased mean platelet volume (HP:0011877)2.04804821
111Keratoconjunctivitis sicca (HP:0001097)2.03913935
112Apathy (HP:0000741)2.02805964
113Cheilitis (HP:0100825)2.02669465
114Brushfield spots (HP:0001088)2.02012218
115Abnormal delayed hypersensitivity skin test (HP:0002963)2.01096163
116Diminished motivation (HP:0000745)2.01015116
117Abnormal gallbladder morphology (HP:0012437)1.98488456
118Hyperglycemia (HP:0003074)1.97658666
119Slow saccadic eye movements (HP:0000514)1.97624790
120Combined immunodeficiency (HP:0005387)1.97426658
121Epistaxis (HP:0000421)1.96809781
122Acanthocytosis (HP:0001927)1.96371749
123Nasal polyposis (HP:0100582)1.96250583
124Male infertility (HP:0003251)1.95535378
125Cholelithiasis (HP:0001081)1.95055872
126Pigmentary retinal degeneration (HP:0001146)1.92415159
127Lower limb hyperreflexia (HP:0002395)1.92173252
128Episodic fever (HP:0001954)1.90955512
129Obstructive sleep apnea (HP:0002870)1.90143122
130Stomatitis (HP:0010280)1.89307792
131Abnormal platelet volume (HP:0011876)1.85352624
132Heterotopia (HP:0002282)1.85251305
133Increased purine levels (HP:0004368)1.84946766
134Hyperuricemia (HP:0002149)1.84946766
135Metabolic acidosis (HP:0001942)1.84778948
136Abnormality of the peritoneum (HP:0002585)1.81402560
137Pancreatitis (HP:0001733)1.80868405
138Mitral stenosis (HP:0001718)1.80032970
139Abnormality of proline metabolism (HP:0010907)1.79469635
140Hydroxyprolinuria (HP:0003080)1.79469635
141Hypoglycemic seizures (HP:0002173)1.79342028
142Thrombophlebitis (HP:0004418)1.78524487
143Absent/shortened dynein arms (HP:0200106)1.78421394
144Dynein arm defect of respiratory motile cilia (HP:0012255)1.78421394
145Centrally nucleated skeletal muscle fibers (HP:0003687)1.75400221
146Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75338520
147Dicarboxylic aciduria (HP:0003215)1.75338520
148Deep philtrum (HP:0002002)1.74495348
149Skin ulcer (HP:0200042)1.73464144
150Chorioretinal atrophy (HP:0000533)1.73287257
151Sensorimotor neuropathy (HP:0007141)1.72827691
152Menorrhagia (HP:0000132)1.72073670
153Late onset (HP:0003584)1.71757601
154Increased connective tissue (HP:0009025)1.69974760
155Infertility (HP:0000789)1.69667056
156Subaortic stenosis (HP:0001682)1.69245005
157Abnormality of the left ventricular outflow tract (HP:0011103)1.69245005
158Back pain (HP:0003418)1.67728477
159Hemoptysis (HP:0002105)1.67436109
160Encephalitis (HP:0002383)1.66741197
161Papillary thyroid carcinoma (HP:0002895)1.66006901
162Bowel incontinence (HP:0002607)1.65768086
163Abnormality of the endocardium (HP:0004306)1.65759864
164Micronodular cirrhosis (HP:0001413)1.65684361
165Abnormal ciliary motility (HP:0012262)1.65105524
166Peritonitis (HP:0002586)1.64833540
167Hepatitis (HP:0012115)1.63939979
168Difficulty running (HP:0009046)1.62994043
169Keratoconjunctivitis (HP:0001096)1.62682559
170Neuronal loss in central nervous system (HP:0002529)1.62058370
171Abnormality of the gallbladder (HP:0005264)1.61847183
172Pseudobulbar signs (HP:0002200)1.61372236
173Elevated erythrocyte sedimentation rate (HP:0003565)1.61016707
174Upper motor neuron abnormality (HP:0002127)1.60786128
175Gastrointestinal stroma tumor (HP:0100723)1.60246197
176Generalized aminoaciduria (HP:0002909)1.59274298
177Colitis (HP:0002583)1.57976765
178Coarse hair (HP:0002208)1.57883221
179Abnormal spermatogenesis (HP:0008669)1.57690184
180Abnormal respiratory motile cilium physiology (HP:0012261)1.57436878
181Sepsis (HP:0100806)1.57068186
182Abnormality of transition element cation homeostasis (HP:0011030)1.56486161
183Abnormal large intestine physiology (HP:0012700)1.55929544
184Hypoplasia of the thymus (HP:0000778)1.55768710
185Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.55547380
186Cone-rod dystrophy (HP:0000548)1.55264088
187Abnormality of the nasal mucosa (HP:0000433)1.54789463
188Termporal pattern (HP:0011008)1.54413296
189Insidious onset (HP:0003587)1.54413296
190Abnormal enzyme/coenzyme activity (HP:0012379)1.52755736
191Spastic paraparesis (HP:0002313)1.52508791
192Acute hepatic failure (HP:0006554)1.50873104
193Irritability (HP:0000737)1.50584997
194Sandal gap (HP:0001852)1.50213821

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.10922824
2CDK123.57676707
3BCKDK3.31861383
4TAOK32.81848864
5PRPF4B2.79553254
6KSR22.72606230
7ACVR1B2.67442606
8FGFR42.53585953
9LATS12.52913214
10EEF2K2.51178846
11EPHB12.48008974
12MAP2K32.42418872
13ERN12.36726988
14MAP3K102.16138819
15SIK12.12468924
16PKN22.11376854
17BLK2.08513742
18CDK91.96694726
19IRAK41.95559946
20TYK21.83337048
21BRSK21.75812585
22BMPR21.72171628
23STK101.69876463
24TTK1.66622435
25MAP3K21.62377803
26ZAP701.60331902
27ARAF1.53534575
28BRD41.51958849
29TRIB31.48790607
30MELK1.47160237
31MAP3K131.45928770
32MAP3K91.45294510
33RAF11.42340995
34FGFR31.40327129
35MAP3K81.38178102
36PRKAA21.34892018
37KSR11.34205339
38IRAK31.33468305
39ERBB41.32933671
40EPHA31.32786272
41MAP3K11.32223876
42FRK1.30583428
43NEK61.30421832
44PTK61.26355276
45WNK11.23736886
46MAP4K11.21445171
47STK31.20894763
48TAOK11.19899447
49CDK41.18979585
50FES1.17545133
51CHUK1.16475676
52FLT31.15486476
53YES11.15469110
54MAP3K61.15316235
55NEK91.13944131
56MAP3K31.12624400
57JAK11.12335624
58PRKAA11.10990163
59MAP3K141.10547772
60FGFR21.06929195
61MAPK111.06724522
62MARK21.04097007
63MOS1.04087878
64MATK1.03818477
65HCK1.01519248
66CAMK1D1.01099117
67LRRK20.99902802
68TRPM70.99039963
69MTOR0.97675174
70CSF1R0.97659539
71SYK0.94769322
72STK110.94699573
73RPS6KA40.94521605
74RPS6KB20.93063007
75CDK70.91264728
76CDC70.90733749
77IRAK20.90715918
78RIPK10.88953035
79TTN0.88646561
80CDK60.87510519
81JAK30.87385823
82CSNK1G10.86280130
83CSNK1A1L0.85909814
84FGR0.84640952
85CAMK1G0.84287154
86STK240.83863169
87JAK20.83193130
88NUAK10.81879351
89PLK40.80161544
90BRAF0.79161105
91IKBKB0.78959771
92RET0.78746050
93MAP3K70.78015500
94MST40.77897438
95TNK20.75684319
96IRAK10.75682642
97SMG10.75533888
98STK40.74815967
99NLK0.73994611
100CDC42BPA0.72002368
101TAOK20.71779940
102MAPKAPK30.71754308
103NEK20.71527950
104DYRK1B0.71464710
105TBK10.70546671
106MARK30.66765013
107ICK0.66751118
108PIK3CG0.66472388
109IKBKE0.65551922
110CSK0.64727979
111STK38L0.62669443
112TEC0.62603683
113MAP3K50.61872029
114SGK30.61321917
115LYN0.61066591
116MUSK0.59255679
117SCYL20.58884111
118PIM10.58479781
119SIK30.56769058
120ITK0.56545834
121BTK0.54578952
122RPS6KB10.53102661
123CSNK1G30.53034800
124GRK60.52277799
125PDPK10.48998180
126CHEK20.48914408
127LCK0.48643963
128ATR0.47812265
129PDK10.47789305
130MST1R0.47207476
131CSNK1D0.46010254
132MAPK120.45432878
133EIF2AK10.44830575
134CLK10.44488825
135AURKB0.41860513
136CSNK1G20.41718828
137CAMKK20.39991925
138GSK3A0.38434032
139PRKD20.38088998
140CHEK10.37261998
141ATM0.36985549
142RPS6KA10.36255810
143BRSK10.35394857
144PKN10.35121962
145INSRR0.34637136
146MAPK100.33884630
147MET0.33276119
148TYRO30.32987381
149GRK10.32930190

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.30752547
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.91678693
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.29188411
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.24302916
5Arginine biosynthesis_Homo sapiens_hsa002202.79629915
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.62785905
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.56203116
8Tryptophan metabolism_Homo sapiens_hsa003802.50915119
9Fatty acid degradation_Homo sapiens_hsa000712.43884951
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.41167980
11Leishmaniasis_Homo sapiens_hsa051402.31912731
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.30128679
13Osteoclast differentiation_Homo sapiens_hsa043802.25830821
14Acute myeloid leukemia_Homo sapiens_hsa052212.24169275
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.19919357
16Complement and coagulation cascades_Homo sapiens_hsa046102.16400076
17Propanoate metabolism_Homo sapiens_hsa006402.04778153
18Non-small cell lung cancer_Homo sapiens_hsa052231.99800203
19Selenocompound metabolism_Homo sapiens_hsa004501.92760803
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.91823311
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.89800513
22Chronic myeloid leukemia_Homo sapiens_hsa052201.89241121
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.88437515
24Peroxisome_Homo sapiens_hsa041461.85122041
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.81166216
26Butanoate metabolism_Homo sapiens_hsa006501.72173383
27Renal cell carcinoma_Homo sapiens_hsa052111.69012118
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.68934932
29Caffeine metabolism_Homo sapiens_hsa002321.67571678
30Tuberculosis_Homo sapiens_hsa051521.65289144
31Histidine metabolism_Homo sapiens_hsa003401.62862023
32Fatty acid metabolism_Homo sapiens_hsa012121.62487820
33Lysine degradation_Homo sapiens_hsa003101.61260136
34PPAR signaling pathway_Homo sapiens_hsa033201.52960864
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.52802037
36Influenza A_Homo sapiens_hsa051641.52170254
37Thyroid cancer_Homo sapiens_hsa052161.50341048
38Endometrial cancer_Homo sapiens_hsa052131.43648067
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.41165145
40Hepatitis B_Homo sapiens_hsa051611.37469521
41VEGF signaling pathway_Homo sapiens_hsa043701.37165868
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.37116973
43Fat digestion and absorption_Homo sapiens_hsa049751.36975568
44Chemical carcinogenesis_Homo sapiens_hsa052041.36625853
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.35845823
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.35785541
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35414007
48Measles_Homo sapiens_hsa051621.35041686
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.34423197
50Inositol phosphate metabolism_Homo sapiens_hsa005621.31451709
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.31028610
52beta-Alanine metabolism_Homo sapiens_hsa004101.30806372
53ABC transporters_Homo sapiens_hsa020101.30030208
54T cell receptor signaling pathway_Homo sapiens_hsa046601.28950532
55Other glycan degradation_Homo sapiens_hsa005111.27942483
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.27293790
57Retinol metabolism_Homo sapiens_hsa008301.27094721
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.26579158
59ErbB signaling pathway_Homo sapiens_hsa040121.23871750
60Folate biosynthesis_Homo sapiens_hsa007901.23833125
61Legionellosis_Homo sapiens_hsa051341.22180971
62Prolactin signaling pathway_Homo sapiens_hsa049171.22017766
63Chemokine signaling pathway_Homo sapiens_hsa040621.21152634
64Staphylococcus aureus infection_Homo sapiens_hsa051501.20371677
65Bile secretion_Homo sapiens_hsa049761.18967328
66Steroid biosynthesis_Homo sapiens_hsa001001.14159865
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13954506
68Platelet activation_Homo sapiens_hsa046111.12361960
69Leukocyte transendothelial migration_Homo sapiens_hsa046701.12147054
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.10561983
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09027018
72Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.08567090
73Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08369079
74Pyruvate metabolism_Homo sapiens_hsa006201.07093516
75Biosynthesis of amino acids_Homo sapiens_hsa012301.05191981
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05109931
77Phagosome_Homo sapiens_hsa041451.04527218
78TNF signaling pathway_Homo sapiens_hsa046681.04044868
79Maturity onset diabetes of the young_Homo sapiens_hsa049501.01861322
80Choline metabolism in cancer_Homo sapiens_hsa052310.99174886
81Amoebiasis_Homo sapiens_hsa051460.99069656
82Shigellosis_Homo sapiens_hsa051310.98756067
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.98165666
84Malaria_Homo sapiens_hsa051440.97532030
85Apoptosis_Homo sapiens_hsa042100.96667348
86Insulin signaling pathway_Homo sapiens_hsa049100.96157658
87Sulfur metabolism_Homo sapiens_hsa009200.95081401
88Glioma_Homo sapiens_hsa052140.94972472
89Glycerolipid metabolism_Homo sapiens_hsa005610.94553642
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.94508470
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94186510
92GnRH signaling pathway_Homo sapiens_hsa049120.92497679
93Phenylalanine metabolism_Homo sapiens_hsa003600.92012079
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91153157
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90752523
96One carbon pool by folate_Homo sapiens_hsa006700.90713183
97Prostate cancer_Homo sapiens_hsa052150.90635467
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90621033
99Colorectal cancer_Homo sapiens_hsa052100.89530831
100Vitamin digestion and absorption_Homo sapiens_hsa049770.88539483
101HIF-1 signaling pathway_Homo sapiens_hsa040660.86753206
102Hematopoietic cell lineage_Homo sapiens_hsa046400.84039365
103Starch and sucrose metabolism_Homo sapiens_hsa005000.83535928
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.82544780
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81503767
106Tyrosine metabolism_Homo sapiens_hsa003500.81249831
107Fatty acid elongation_Homo sapiens_hsa000620.79201576
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78470531
109Long-term potentiation_Homo sapiens_hsa047200.76546868
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76272545
111Carbon metabolism_Homo sapiens_hsa012000.76254827
112Salmonella infection_Homo sapiens_hsa051320.75644321
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.75603602
114Linoleic acid metabolism_Homo sapiens_hsa005910.74750308
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.74083342
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74072867
117Estrogen signaling pathway_Homo sapiens_hsa049150.72856707
118Type II diabetes mellitus_Homo sapiens_hsa049300.72489634
119Bladder cancer_Homo sapiens_hsa052190.71466407
120Endocytosis_Homo sapiens_hsa041440.71357575
121Arginine and proline metabolism_Homo sapiens_hsa003300.70860773
122Adherens junction_Homo sapiens_hsa045200.70398890
123Insulin resistance_Homo sapiens_hsa049310.69387708
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64340521
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64297971
126Allograft rejection_Homo sapiens_hsa053300.64174790
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63999581
128Lysosome_Homo sapiens_hsa041420.62468649
129Epstein-Barr virus infection_Homo sapiens_hsa051690.61632136
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61324599
131Fatty acid biosynthesis_Homo sapiens_hsa000610.60789652
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60059081
133Gap junction_Homo sapiens_hsa045400.59842647
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59473879
135Autoimmune thyroid disease_Homo sapiens_hsa053200.59294456
136African trypanosomiasis_Homo sapiens_hsa051430.58528633
137HTLV-I infection_Homo sapiens_hsa051660.57880594
138Proteoglycans in cancer_Homo sapiens_hsa052050.56697518
139Pertussis_Homo sapiens_hsa051330.56536278
140Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52484965
141Adipocytokine signaling pathway_Homo sapiens_hsa049200.51553499
142Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50094393
143NF-kappa B signaling pathway_Homo sapiens_hsa040640.47454397
144Pentose phosphate pathway_Homo sapiens_hsa000300.46851051
145Viral myocarditis_Homo sapiens_hsa054160.45673470
146Systemic lupus erythematosus_Homo sapiens_hsa053220.44856386
147Small cell lung cancer_Homo sapiens_hsa052220.43679978
148Pancreatic cancer_Homo sapiens_hsa052120.43433162
149Non-homologous end-joining_Homo sapiens_hsa034500.42540366
150Sulfur relay system_Homo sapiens_hsa041220.40835454
151AMPK signaling pathway_Homo sapiens_hsa041520.40727552
152mTOR signaling pathway_Homo sapiens_hsa041500.38625300
153Primary immunodeficiency_Homo sapiens_hsa053400.38532343
154Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33902971
155Viral carcinogenesis_Homo sapiens_hsa052030.33533106
156Glutathione metabolism_Homo sapiens_hsa004800.31045754
157Ovarian steroidogenesis_Homo sapiens_hsa049130.30538064
158Vitamin B6 metabolism_Homo sapiens_hsa007500.30528357
159Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29409691
160Notch signaling pathway_Homo sapiens_hsa043300.29121621
161Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27730227
162Circadian rhythm_Homo sapiens_hsa047100.27659269
163Glycerophospholipid metabolism_Homo sapiens_hsa005640.24680295
164Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24047869
165Cell cycle_Homo sapiens_hsa041100.22388890
166Dorso-ventral axis formation_Homo sapiens_hsa043200.21942766
167Toxoplasmosis_Homo sapiens_hsa051450.21914058
168MicroRNAs in cancer_Homo sapiens_hsa052060.20835369
169B cell receptor signaling pathway_Homo sapiens_hsa046620.19444726
170Antigen processing and presentation_Homo sapiens_hsa046120.18438592
171FoxO signaling pathway_Homo sapiens_hsa040680.18110826
172p53 signaling pathway_Homo sapiens_hsa041150.17936467
173Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17755876
174Jak-STAT signaling pathway_Homo sapiens_hsa046300.17541133
175Herpes simplex infection_Homo sapiens_hsa051680.17457625
176NOD-like receptor signaling pathway_Homo sapiens_hsa046210.16791648
177Metabolic pathways_Homo sapiens_hsa011000.16351909
178RNA degradation_Homo sapiens_hsa030180.16142434
179Hepatitis C_Homo sapiens_hsa051600.14767676

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