KDM2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.32075531
2nuclear pore organization (GO:0006999)4.30390047
3nuclear pore complex assembly (GO:0051292)4.13417425
4protein localization to kinetochore (GO:0034501)4.09783799
5mitotic nuclear envelope disassembly (GO:0007077)3.79408272
6B cell receptor signaling pathway (GO:0050853)3.74355949
7regulation of B cell receptor signaling pathway (GO:0050855)3.64825696
8pre-miRNA processing (GO:0031054)3.63483917
9mitotic metaphase plate congression (GO:0007080)3.61495061
10negative thymic T cell selection (GO:0045060)3.60497020
11regulation of gamma-delta T cell activation (GO:0046643)3.59085219
12DNA replication checkpoint (GO:0000076)3.56819474
13DNA unwinding involved in DNA replication (GO:0006268)3.54461177
14nuclear envelope disassembly (GO:0051081)3.53623588
15membrane disassembly (GO:0030397)3.53623588
16DNA replication-dependent nucleosome assembly (GO:0006335)3.53109643
17DNA replication-dependent nucleosome organization (GO:0034723)3.53109643
18protein localization to chromosome, centromeric region (GO:0071459)3.50784100
19regulation of nuclear cell cycle DNA replication (GO:0033262)3.46322085
20nucleosome disassembly (GO:0006337)3.44907730
21protein-DNA complex disassembly (GO:0032986)3.44907730
22positive thymic T cell selection (GO:0045059)3.43651205
23regulation of gamma-delta T cell differentiation (GO:0045586)3.37092834
24DNA replication initiation (GO:0006270)3.36710799
25negative T cell selection (GO:0043383)3.36642258
26thymic T cell selection (GO:0045061)3.36250115
27ribosome biogenesis (GO:0042254)3.35880208
28negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.33800309
29positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.32584173
30formation of translation preinitiation complex (GO:0001731)3.30965012
31negative regulation of histone modification (GO:0031057)3.29176456
32V(D)J recombination (GO:0033151)3.28957171
33nucleobase biosynthetic process (GO:0046112)3.28249830
34positive regulation of B cell differentiation (GO:0045579)3.27797860
35pore complex assembly (GO:0046931)3.27772501
36negative regulation of translation, ncRNA-mediated (GO:0040033)3.24804505
37regulation of translation, ncRNA-mediated (GO:0045974)3.24804505
38negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.24804505
39metaphase plate congression (GO:0051310)3.22155490
40DNA strand elongation involved in DNA replication (GO:0006271)3.21079280
41folic acid-containing compound biosynthetic process (GO:0009396)3.20365609
42negative regulation of chromatin modification (GO:1903309)3.18601608
43chromatin silencing (GO:0006342)3.16082033
44mitotic sister chromatid segregation (GO:0000070)3.15997375
45regulation of histone methylation (GO:0031060)3.15260058
46regulation of gene silencing (GO:0060968)3.13590407
47dosage compensation (GO:0007549)3.13316831
48negative regulation of RNA splicing (GO:0033119)3.12112087
49regulation of NFAT protein import into nucleus (GO:0051532)3.12001460
50histone H4-K12 acetylation (GO:0043983)3.11503340
51mitotic sister chromatid cohesion (GO:0007064)3.10807573
52regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.09165277
53DNA duplex unwinding (GO:0032508)3.09043984
54histone H3-K9 methylation (GO:0051567)3.08350512
55regulation of B cell differentiation (GO:0045577)3.08291776
56DNA strand elongation (GO:0022616)3.07819585
57DNA geometric change (GO:0032392)3.07331063
58regulation of spindle organization (GO:0090224)3.07005367
59negative regulation of gene expression, epigenetic (GO:0045814)3.05221076
60regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.04256666
61positive regulation of gene expression, epigenetic (GO:0045815)3.04213788
62T cell selection (GO:0045058)3.02618392
63mucosal-associated lymphoid tissue development (GO:0048537)3.02555055
64Peyers patch development (GO:0048541)3.02555055
65mitotic chromosome condensation (GO:0007076)3.01399821
66IMP biosynthetic process (GO:0006188)3.00318163
67sister chromatid segregation (GO:0000819)2.98846908
68* histone H3-K36 demethylation (GO:0070544)2.97996345
69regulation of chromatin silencing (GO:0031935)2.97367000
70telomere maintenance via semi-conservative replication (GO:0032201)2.96262199
71negative regulation of histone methylation (GO:0031061)2.96131379
72maturation of SSU-rRNA (GO:0030490)2.95831272
73response to muramyl dipeptide (GO:0032495)2.95469923
74positive regulation of chromosome segregation (GO:0051984)2.94061481
75establishment of chromosome localization (GO:0051303)2.93382311
76histone H3-K9 modification (GO:0061647)2.90934777
77ribosome assembly (GO:0042255)2.90642147
78protein localization to chromosome (GO:0034502)2.90229734
79negative regulation of mRNA processing (GO:0050686)2.90035916
80purine nucleobase biosynthetic process (GO:0009113)2.89499370
81regulation of histone H3-K4 methylation (GO:0051569)2.88847999
82B cell homeostasis (GO:0001782)2.87913089
83regulation of telomere maintenance via telomerase (GO:0032210)2.87668618
84negative regulation of cell killing (GO:0031342)2.86809283
85negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.86809283
86positive T cell selection (GO:0043368)2.86488713
87DNA replication-independent nucleosome assembly (GO:0006336)2.86340688
88DNA replication-independent nucleosome organization (GO:0034724)2.86340688
89natural killer cell differentiation (GO:0001779)2.85920440
90spliceosomal tri-snRNP complex assembly (GO:0000244)2.84385302
91positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.83930682
92attachment of spindle microtubules to kinetochore (GO:0008608)2.83257406
93regulation of RNA export from nucleus (GO:0046831)2.83171984
94nuclear envelope organization (GO:0006998)2.81046960
95histone H2A acetylation (GO:0043968)2.78612354
96regulation of histone H3-K9 methylation (GO:0051570)2.78463956
97mitotic recombination (GO:0006312)2.76765309
98T cell lineage commitment (GO:0002360)2.76741720
99kinetochore organization (GO:0051383)2.76445640
100RNA splicing, via transesterification reactions (GO:0000375)2.75741229
101telomere maintenance via recombination (GO:0000722)2.75325663
102RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.74873820
103mRNA splicing, via spliceosome (GO:0000398)2.74873820
104histone H4-K16 acetylation (GO:0043984)2.74763881
105negative regulation of chromosome segregation (GO:0051985)2.74430953
106regulation of histone H3-K27 methylation (GO:0061085)2.73240178
107mRNA transport (GO:0051028)2.72443327
108spindle checkpoint (GO:0031577)2.72256564
109positive regulation of SMAD protein import into nucleus (GO:0060391)2.71484616
110regulation of translation in response to stress (GO:0043555)2.71479019
111regulation of double-strand break repair via homologous recombination (GO:0010569)2.71247458
112chromatin assembly or disassembly (GO:0006333)2.69627308
113ribonucleoprotein complex biogenesis (GO:0022613)2.69516877
114negative regulation of mRNA metabolic process (GO:1903312)2.69246134
115regulation of chromosome segregation (GO:0051983)2.68928313
116mitotic spindle checkpoint (GO:0071174)2.68149119
117heterochromatin organization (GO:0070828)2.68143453
118regulation of chromatin binding (GO:0035561)2.68045692
119intracellular estrogen receptor signaling pathway (GO:0030520)2.67343482
120maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.67012459
121spindle assembly checkpoint (GO:0071173)2.66796556
122negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.66198300
123negative regulation of sister chromatid segregation (GO:0033046)2.66198300
124negative regulation of mitotic sister chromatid separation (GO:2000816)2.66198300
125negative regulation of mitotic sister chromatid segregation (GO:0033048)2.66198300
126mitotic spindle assembly checkpoint (GO:0007094)2.64474509
127regulation of posttranscriptional gene silencing (GO:0060147)2.64111346
128regulation of gene silencing by miRNA (GO:0060964)2.64111346
129regulation of gene silencing by RNA (GO:0060966)2.64111346
130translesion synthesis (GO:0019985)2.63730917
131regulation of interleukin-2 biosynthetic process (GO:0045076)2.63156883
132RNA export from nucleus (GO:0006405)2.63155008
133negative regulation of erythrocyte differentiation (GO:0045647)2.62613331
134histone arginine methylation (GO:0034969)2.61956734
135negative regulation of gene silencing (GO:0060969)2.60518432
136rRNA processing (GO:0006364)2.59453516
137regulation of mitotic metaphase/anaphase transition (GO:0030071)2.59135966
138kinetochore assembly (GO:0051382)2.59088498
139DNA synthesis involved in DNA repair (GO:0000731)2.59076508
140histone H4-K5 acetylation (GO:0043981)2.58575263
141histone H4-K8 acetylation (GO:0043982)2.58575263
142DNA conformation change (GO:0071103)2.58566146
143T cell migration (GO:0072678)2.58428783
144mRNA export from nucleus (GO:0006406)2.58298803
145somatic diversification of immune receptors via somatic mutation (GO:0002566)2.57957297
146somatic hypermutation of immunoglobulin genes (GO:0016446)2.57957297
147negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.57702322
1483-UTR-mediated mRNA stabilization (GO:0070935)2.57030276
149maturation of 5.8S rRNA (GO:0000460)2.56496614
150mannose metabolic process (GO:0006013)2.56138308
151DNA alkylation (GO:0006305)2.55840367
152DNA methylation (GO:0006306)2.55840367
153mRNA splice site selection (GO:0006376)2.55571554
154chromatin remodeling at centromere (GO:0031055)2.55441313
155termination of RNA polymerase II transcription (GO:0006369)2.55414520
156positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.55281661
157RNA stabilization (GO:0043489)2.55223713
158mRNA stabilization (GO:0048255)2.55223713
159histone H3-K4 methylation (GO:0051568)2.54961803
160determination of adult lifespan (GO:0008340)2.54799950
161rRNA metabolic process (GO:0016072)2.54738263
162telomere maintenance via telomere lengthening (GO:0010833)2.54239519
163chromatin assembly (GO:0031497)2.53689323
164positive regulation by host of viral transcription (GO:0043923)2.52764705
165B cell proliferation (GO:0042100)2.50849185
166CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.49232766
167DNA topological change (GO:0006265)2.48828393
168positive regulation of histone methylation (GO:0031062)2.48706807

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.88675422
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.33933063
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.68495237
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.55812329
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.14898272
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.05063854
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.81410587
8* MYC_22102868_ChIP-Seq_BL_Human2.80290688
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.61269665
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.46317448
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.37231841
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.36075824
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.34791463
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.23947482
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.18172175
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.15385545
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.05876993
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.03895968
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.02013163
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.00868232
21VDR_23849224_ChIP-Seq_CD4+_Human1.99634768
22NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99060323
23E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.98676133
24XRN2_22483619_ChIP-Seq_HELA_Human1.96614897
25CIITA_25753668_ChIP-Seq_RAJI_Human1.96594678
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.93148392
27VDR_24763502_ChIP-Seq_THP-1_Human1.85456720
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85431563
29KDM2B_26808549_Chip-Seq_DND41_Human1.85068668
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.84295127
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.83666674
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.83232059
33* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.82906000
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.81497414
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79916435
36FOXP3_21729870_ChIP-Seq_TREG_Human1.75820911
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75295920
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72288845
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68703025
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.67715049
41MAF_26560356_Chip-Seq_TH2_Human1.67707455
42SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.66065747
43KDM5A_27292631_Chip-Seq_BREAST_Human1.65479041
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65476735
45AR_21909140_ChIP-Seq_LNCAP_Human1.63398330
46KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.61654716
47KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.61654716
48KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.61654716
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56834769
50TTF2_22483619_ChIP-Seq_HELA_Human1.56283337
51GABP_19822575_ChIP-Seq_HepG2_Human1.55891957
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.54983625
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54942251
54IRF8_21731497_ChIP-ChIP_J774_Mouse1.53360118
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.53293611
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51594584
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48144765
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46155034
59* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.45094168
60VDR_21846776_ChIP-Seq_THP-1_Human1.45082789
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44656994
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.43427526
63DCP1A_22483619_ChIP-Seq_HELA_Human1.40730048
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39685185
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.36612856
66E2F1_18555785_ChIP-Seq_MESCs_Mouse1.35261624
67* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.30746542
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29739636
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29314415
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26216786
71RUNX1_22412390_ChIP-Seq_EML_Mouse1.25911109
72KDM2B_26808549_Chip-Seq_JURKAT_Human1.24645844
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24404821
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23053209
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23017910
76YY1_21170310_ChIP-Seq_MESCs_Mouse1.22936679
77ELK1_19687146_ChIP-ChIP_HELA_Human1.22788307
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22203040
79* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21936774
80BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21496691
81RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21312960
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20195068
83TCF7_22412390_ChIP-Seq_EML_Mouse1.20005551
84ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19756301
85NCOR1_26117541_ChIP-Seq_K562_Human1.16348217
86STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15051623
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14102479
88* MYB_26560356_Chip-Seq_TH1_Human1.13661394
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13545647
90SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13104848
91EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12497344
92TFEB_21752829_ChIP-Seq_HELA_Human1.12251332
93E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11823770
94* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11666484
95SPI1_23547873_ChIP-Seq_NB4_Human1.11379966
96LXR_22292898_ChIP-Seq_THP-1_Human1.10399143
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09201749
98RUNX_20019798_ChIP-Seq_JUKART_Human1.08729114
99SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08259593
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07857779
101ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07781378
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07679198
103IRF8_27001747_Chip-Seq_BMDM_Mouse1.07544920
104IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.06554997
105NANOG_21062744_ChIP-ChIP_HESCs_Human1.06118032
106ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05324031
107PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04584056
108POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03710985
109* MAF_26560356_Chip-Seq_TH1_Human1.03707740
110MYB_26560356_Chip-Seq_TH2_Human1.03572985
111NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.03495873
112* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03252387
113STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02746841
114UTX_26944678_Chip-Seq_JUKART_Human1.01964211
115NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00423500
116HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00108165
117P68_20966046_ChIP-Seq_HELA_Human0.99641215
118MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98635505
119TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98586466
120PKCTHETA_26484144_Chip-Seq_BREAST_Human0.98038603
121FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98033943
122* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97337475
123GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97150412
124SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.95595390
125* GATA3_27048872_Chip-Seq_THYMUS_Human0.95100690
126STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.93660684
127SCL_19346495_ChIP-Seq_HPC-7_Human0.93646600
128* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.93448835
129SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93099985
130KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92288572
131IRF1_19129219_ChIP-ChIP_H3396_Human0.91000492
132RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.89954983
133FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.89828873
134* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89200816
135KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89180901
136ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88212047
137SOX2_16153702_ChIP-ChIP_HESCs_Human0.87835215
138* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86272259
139SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85668246

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.28535114
2MP0010094_abnormal_chromosome_stability3.86503069
3MP0008057_abnormal_DNA_replication3.82663353
4MP0003111_abnormal_nucleus_morphology3.77344729
5MP0004957_abnormal_blastocyst_morpholog3.39349622
6MP0003077_abnormal_cell_cycle3.34770606
7MP0008058_abnormal_DNA_repair2.88490618
8MP0002254_reproductive_system_inflammat2.84387858
9MP0002396_abnormal_hematopoietic_system2.71570933
10MP0008007_abnormal_cellular_replicative2.56475014
11MP0002009_preneoplasia2.48529086
12MP0000350_abnormal_cell_proliferation2.15109597
13MP0003763_abnormal_thymus_physiology2.11408420
14MP0010352_gastrointestinal_tract_polyps2.09254758
15MP0005076_abnormal_cell_differentiation2.05765490
16MP0008877_abnormal_DNA_methylation1.97710437
17MP0001730_embryonic_growth_arrest1.91683551
18MP0000490_abnormal_crypts_of1.88141158
19MP0004808_abnormal_hematopoietic_stem1.84907489
20MP0006292_abnormal_olfactory_placode1.83864358
21MP0008932_abnormal_embryonic_tissue1.83476617
22MP0001672_abnormal_embryogenesis/_devel1.82260838
23MP0005380_embryogenesis_phenotype1.82260838
24MP0010307_abnormal_tumor_latency1.77352858
25MP0003890_abnormal_embryonic-extraembry1.72471968
26MP0003172_abnormal_lysosome_physiology1.71625218
27MP0003984_embryonic_growth_retardation1.66561540
28MP0002088_abnormal_embryonic_growth/wei1.64283804
29MP0002398_abnormal_bone_marrow1.61800428
30MP0003123_paternal_imprinting1.59606565
31MP0000703_abnormal_thymus_morphology1.59500533
32MP0003786_premature_aging1.57582607
33MP0002084_abnormal_developmental_patter1.55738883
34MP0001697_abnormal_embryo_size1.55638864
35MP0002085_abnormal_embryonic_tissue1.52260976
36MP0009333_abnormal_splenocyte_physiolog1.51494528
37MP0001545_abnormal_hematopoietic_system1.47309710
38MP0005397_hematopoietic_system_phenotyp1.47309710
39MP0002086_abnormal_extraembryonic_tissu1.44419135
40MP0002080_prenatal_lethality1.43762958
41MP0005310_abnormal_salivary_gland1.43678117
42MP0003121_genomic_imprinting1.42393246
43MP0000313_abnormal_cell_death1.39516214
44MP0005671_abnormal_response_to1.39490030
45MP0002877_abnormal_melanocyte_morpholog1.33584212
46MP0001800_abnormal_humoral_immune1.33531046
47MP0002722_abnormal_immune_system1.31231284
48MP0004197_abnormal_fetal_growth/weight/1.30477840
49MP0005025_abnormal_response_to1.30387660
50MP0002019_abnormal_tumor_incidence1.29792491
51MP0009278_abnormal_bone_marrow1.29273754
52MP0001293_anophthalmia1.28234560
53MP0002419_abnormal_innate_immunity1.26521892
54MP0000689_abnormal_spleen_morphology1.25045918
55MP0004947_skin_inflammation1.24893242
56MP0003787_abnormal_imprinting1.23753495
57MP0000685_abnormal_immune_system1.22755538
58MP0003567_abnormal_fetal_cardiomyocyte1.18739358
59MP0000716_abnormal_immune_system1.18050306
60MP0005451_abnormal_body_composition1.17841752
61MP0001835_abnormal_antigen_presentation1.15019771
62MP0003718_maternal_effect1.14317895
63MP0002429_abnormal_blood_cell1.14027475
64MP0002210_abnormal_sex_determination1.08704529
65MP0002420_abnormal_adaptive_immunity1.08574003
66MP0004381_abnormal_hair_follicle1.08572002
67MP0001819_abnormal_immune_cell1.08339454
68MP0002405_respiratory_system_inflammati1.07261993
69MP0002452_abnormal_antigen_presenting1.07128109
70MP0002148_abnormal_hypersensitivity_rea1.05308218
71MP0002723_abnormal_immune_serum1.05271562
72MP0001853_heart_inflammation1.02598889
73MP0004264_abnormal_extraembryonic_tissu1.01386154
74MP0003303_peritoneal_inflammation1.01364407
75MP0004185_abnormal_adipocyte_glucose0.99021247
76MP0001790_abnormal_immune_system0.97944248
77MP0005387_immune_system_phenotype0.97944248
78MP0005377_hearing/vestibular/ear_phenot0.97710568
79MP0003878_abnormal_ear_physiology0.97710568
80MP0002138_abnormal_hepatobiliary_system0.95996674
81MP0003119_abnormal_digestive_system0.95707879
82MP0002653_abnormal_ependyma_morphology0.95406155
83MP0001145_abnormal_male_reproductive0.94613705
84MP0001346_abnormal_lacrimal_gland0.92238418
85MP0003436_decreased_susceptibility_to0.91086719
86MP0005000_abnormal_immune_tolerance0.90754382
87MP0001929_abnormal_gametogenesis0.88532346
88MP0010030_abnormal_orbit_morphology0.88134932
89MP0009672_abnormal_birth_weight0.87429916
90MP0009703_decreased_birth_body0.86996846
91MP0002163_abnormal_gland_morphology0.86289171
92MP0000569_abnormal_digit_pigmentation0.85780452
93MP0003943_abnormal_hepatobiliary_system0.83279557
94MP0005621_abnormal_cell_physiology0.82822982
95MP0003866_abnormal_defecation0.82686465
96MP0005174_abnormal_tail_pigmentation0.82113010
97MP0002092_abnormal_eye_morphology0.81878376
98MP0004742_abnormal_vestibular_system0.80837778
99MP0005384_cellular_phenotype0.79775532
100MP0001915_intracranial_hemorrhage0.78996545
101MP0005075_abnormal_melanosome_morpholog0.78793481
102MP0001119_abnormal_female_reproductive0.77960015
103MP0000428_abnormal_craniofacial_morphol0.77601112
104MP0010155_abnormal_intestine_physiology0.77336258
105MP0000653_abnormal_sex_gland0.77190433
106MP0003861_abnormal_nervous_system0.76163139
107MP0001348_abnormal_lacrimal_gland0.75703117
108MP0000465_gastrointestinal_hemorrhage0.75088217
109MP0005647_abnormal_sex_gland0.74806049
110MP0002006_tumorigenesis0.74389195
111MP0001849_ear_inflammation0.73576684
112MP0000015_abnormal_ear_pigmentation0.73198746
113MP0002166_altered_tumor_susceptibility0.72433694
114MP0002111_abnormal_tail_morphology0.69889591
115MP0003937_abnormal_limbs/digits/tail_de0.69784009
116MP0000371_diluted_coat_color0.69583230
117MP0002075_abnormal_coat/hair_pigmentati0.68959267
118MP0000678_abnormal_parathyroid_gland0.68272945
119MP0000858_altered_metastatic_potential0.65211835
120MP0001873_stomach_inflammation0.64126310
121MP0002095_abnormal_skin_pigmentation0.63352346
122MP0001845_abnormal_inflammatory_respons0.62532734
123MP0002925_abnormal_cardiovascular_devel0.62127802
124MP0003300_gastrointestinal_ulcer0.60944851
125MP0002998_abnormal_bone_remodeling0.60502538
126MP0002796_impaired_skin_barrier0.60451571
127MP0005645_abnormal_hypothalamus_physiol0.58605089

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)4.14973342
2Chromsome breakage (HP:0040012)3.64739950
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.57524612
4Birth length less than 3rd percentile (HP:0003561)3.51026691
5Ependymoma (HP:0002888)3.13392356
6Colitis (HP:0002583)3.07063079
7Lymphopenia (HP:0001888)3.04484306
8Gastrointestinal stroma tumor (HP:0100723)3.02348246
9Acute lymphatic leukemia (HP:0006721)2.99262417
10Meningitis (HP:0001287)2.96661410
11Patellar aplasia (HP:0006443)2.94366083
12Abnormality of cells of the lymphoid lineage (HP:0012140)2.92648267
13Medulloblastoma (HP:0002885)2.88828548
14Chronic mucocutaneous candidiasis (HP:0002728)2.86725606
15Recurrent cutaneous fungal infections (HP:0011370)2.86725606
16Aplasia/Hypoplasia of the uvula (HP:0010293)2.78698177
17Abnormality of chromosome stability (HP:0003220)2.77886057
18Volvulus (HP:0002580)2.77169562
19Aplasia/Hypoplasia of the patella (HP:0006498)2.74047018
20Abnormality of the anterior horn cell (HP:0006802)2.73202969
21Degeneration of anterior horn cells (HP:0002398)2.73202969
22Impulsivity (HP:0100710)2.71170728
23Myelodysplasia (HP:0002863)2.70458388
24Meckel diverticulum (HP:0002245)2.66235082
25Ectopic kidney (HP:0000086)2.61018669
26Mediastinal lymphadenopathy (HP:0100721)2.60580662
27Increased neuronal autofluorescent lipopigment (HP:0002074)2.57820729
28Protruding tongue (HP:0010808)2.57757842
29Abnormality of the ileum (HP:0001549)2.57630204
30Abnormality of the labia minora (HP:0012880)2.57255467
31Prominent nose (HP:0000448)2.56278608
32Abnormality of the fingertips (HP:0001211)2.55956197
33Abnormality of the preputium (HP:0100587)2.55710487
34Recurrent sinusitis (HP:0011108)2.54192337
35Selective tooth agenesis (HP:0001592)2.53701428
36T lymphocytopenia (HP:0005403)2.47818401
37Increased cerebral lipofuscin (HP:0011813)2.45174375
38IgM deficiency (HP:0002850)2.42829461
39Gastrointestinal inflammation (HP:0004386)2.42220687
40Breast hypoplasia (HP:0003187)2.40731752
41Amaurosis fugax (HP:0100576)2.33999062
42Recurrent bacterial skin infections (HP:0005406)2.32840917
43Cellulitis (HP:0100658)2.32519315
44Trigonocephaly (HP:0000243)2.30535689
45Facial hemangioma (HP:0000329)2.30515309
46Nephroblastoma (Wilms tumor) (HP:0002667)2.30328260
47B lymphocytopenia (HP:0010976)2.30037217
48Hyperacusis (HP:0010780)2.27907758
49Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.26231811
50Rhabdomyosarcoma (HP:0002859)2.25721733
51Inflammation of the large intestine (HP:0002037)2.24410586
52Aplastic anemia (HP:0001915)2.24075527
53Viral hepatitis (HP:0006562)2.23166853
54Reticulocytopenia (HP:0001896)2.22466077
55Abnormality of the astrocytes (HP:0100707)2.20031078
56Astrocytoma (HP:0009592)2.20031078
57Colon cancer (HP:0003003)2.19823798
58Abnormality of B cell number (HP:0010975)2.17440130
59Supernumerary spleens (HP:0009799)2.17191491
60Abnormal number of incisors (HP:0011064)2.16766642
61Carpal bone hypoplasia (HP:0001498)2.16334913
62Hypoplasia of the thymus (HP:0000778)2.16282421
63Bone marrow hypocellularity (HP:0005528)2.15935396
64Absent thumb (HP:0009777)2.14876140
65Abnormality of T cell number (HP:0011839)2.14297438
66Absent radius (HP:0003974)2.13993040
67Increased nuchal translucency (HP:0010880)2.12944684
68Spinal muscular atrophy (HP:0007269)2.11452056
69Recurrent abscess formation (HP:0002722)2.10983510
70Atrophy/Degeneration involving motor neurons (HP:0007373)2.09470963
71Eczematoid dermatitis (HP:0000976)2.08308610
72Embryonal renal neoplasm (HP:0011794)2.07723054
73High anterior hairline (HP:0009890)2.07193184
74Duodenal stenosis (HP:0100867)2.06235295
75Small intestinal stenosis (HP:0012848)2.06235295
76Abnormality of the columella (HP:0009929)2.04921468
77Thrombocytosis (HP:0001894)2.04090177
78Severe combined immunodeficiency (HP:0004430)2.03824542
79Aplasia/Hypoplasia of the sternum (HP:0006714)2.03750080
80Glioma (HP:0009733)2.03248402
81Neoplasm of the adrenal cortex (HP:0100641)2.02748169
82Lymphoma (HP:0002665)2.02547891
83Hepatoblastoma (HP:0002884)2.02076124
84Increased IgE level (HP:0003212)2.01080479
85Agnosia (HP:0010524)2.01056859
8611 pairs of ribs (HP:0000878)2.00293849
87Basal cell carcinoma (HP:0002671)1.99790663
88Proximal placement of thumb (HP:0009623)1.99379256
89Skull defect (HP:0001362)1.99173302
90Deep palmar crease (HP:0006191)1.99041635
91Recurrent skin infections (HP:0001581)1.98946993
92Acute myeloid leukemia (HP:0004808)1.98801180
93Bilateral microphthalmos (HP:0007633)1.97147133
94Absent forearm bone (HP:0003953)1.96642210
95Aplasia involving forearm bones (HP:0009822)1.96642210
96Neoplasm of striated muscle (HP:0009728)1.94892005
97Neoplasm of the oral cavity (HP:0100649)1.94412094
98Dysmetric saccades (HP:0000641)1.94272613
99Sloping forehead (HP:0000340)1.94200104
100Deviation of the thumb (HP:0009603)1.93500306
101Cleft eyelid (HP:0000625)1.91995026
102Premature ovarian failure (HP:0008209)1.91968177
103Vasculitis (HP:0002633)1.91612429
104Abnormality of the carotid arteries (HP:0005344)1.91297546
105Clumsiness (HP:0002312)1.90827948
106Rib fusion (HP:0000902)1.89515757
107Cutis marmorata (HP:0000965)1.88401355
108Leukopenia (HP:0001882)1.88289924
109Long eyelashes (HP:0000527)1.86856522
110Premature graying of hair (HP:0002216)1.86296299
111Restrictive lung disease (HP:0002091)1.85636969
112Abnormality of chromosome segregation (HP:0002916)1.85554704
113Papilloma (HP:0012740)1.85524219
114Verrucae (HP:0200043)1.85524219
115Obsessive-compulsive behavior (HP:0000722)1.84807881
116Broad thumb (HP:0011304)1.84000698
117Oral leukoplakia (HP:0002745)1.83903875
118Anal stenosis (HP:0002025)1.83736148
119Tracheoesophageal fistula (HP:0002575)1.83469444
120Panhypogammaglobulinemia (HP:0003139)1.83094193
121Atresia of the external auditory canal (HP:0000413)1.82557443
122Abnormal delayed hypersensitivity skin test (HP:0002963)1.82298318
123Recurrent lower respiratory tract infections (HP:0002783)1.82129792
124Rough bone trabeculation (HP:0100670)1.81922330
125Abnormality of the prostate (HP:0008775)1.80839154
126Cafe-au-lait spot (HP:0000957)1.80636677
127Optic nerve coloboma (HP:0000588)1.80016978
128Abnormality of the duodenum (HP:0002246)1.79089653
129IgG deficiency (HP:0004315)1.78898548
130Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.78862373
131Short 4th metacarpal (HP:0010044)1.78862373
132Clubbing of toes (HP:0100760)1.78679621
133Abnormality of DNA repair (HP:0003254)1.77474823
134Abnormality of T cell physiology (HP:0011840)1.76180648
135Shawl scrotum (HP:0000049)1.76001810
136Abnormal number of erythroid precursors (HP:0012131)1.75753842
137Neoplasm of the pancreas (HP:0002894)1.73609638
138Missing ribs (HP:0000921)1.72372539
139Increased density of long bones (HP:0006392)1.71554292
140Aplasia/Hypoplasia of the thymus (HP:0010515)1.71361173
141Personality changes (HP:0000751)1.71358661
142Abnormality of male internal genitalia (HP:0000022)1.71339730
143Abnormality of T cells (HP:0002843)1.71295777
144Thoracic kyphosis (HP:0002942)1.70467168
145Horseshoe kidney (HP:0000085)1.70259378
146Abnormal lung lobation (HP:0002101)1.70238484
147Abnormality of cells of the erythroid lineage (HP:0012130)1.70198942
148Neonatal hypoglycemia (HP:0001998)1.70047000
149Encephalitis (HP:0002383)1.69658324
150Gastrointestinal carcinoma (HP:0002672)1.68902664
151Malignant gastrointestinal tract tumors (HP:0006749)1.68902664
152Chronic obstructive pulmonary disease (HP:0006510)1.68169418
153Obstructive lung disease (HP:0006536)1.68169418
154Recurrent pneumonia (HP:0006532)1.67215537
155Short thumb (HP:0009778)1.66965346
156Intestinal fistula (HP:0100819)1.66327823
157Trismus (HP:0000211)1.66156417
158IgA deficiency (HP:0002720)1.65712161
159Abnormality of the salivary glands (HP:0010286)1.65220281
160Combined immunodeficiency (HP:0005387)1.65093417
161Recurrent viral infections (HP:0004429)1.64823742
162Squamous cell carcinoma (HP:0002860)1.64719200
163Osteomyelitis (HP:0002754)1.64659526
164Pustule (HP:0200039)1.64283763
165Overlapping toe (HP:0001845)1.63947275
166Premature loss of primary teeth (HP:0006323)1.63494739
167Abnormality of the metopic suture (HP:0005556)1.63377385
168Recurrent fungal infections (HP:0002841)1.63218248
169Overriding aorta (HP:0002623)1.62498305
170Urethral obstruction (HP:0000796)1.62260572

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.87981529
2SMG13.59949955
3TSSK63.18858192
4CDC73.12797397
5WEE12.89257862
6BUB12.83964452
7NEK22.64104374
8EEF2K2.60358539
9RIPK42.49594728
10PRPF4B2.39056502
11TTK2.32819227
12SRPK12.31082053
13PASK2.06607261
14MAP4K11.94946297
15TRIB31.88555160
16CAMK1D1.87092883
17ATR1.75597018
18TAF11.69687941
19DYRK31.67513450
20ACVR1B1.67040300
21MAP3K131.66227117
22MKNK11.63449796
23CDK71.60490317
24MAP3K101.59939299
25PLK11.59164125
26CAMK1G1.57609458
27BRD41.57540000
28CHUK1.56999567
29CDK41.56923245
30MKNK21.54728933
31STK101.53569815
32CHEK21.52891875
33RPS6KA41.48408427
34EPHA21.41883697
35CHEK11.41382731
36PLK41.40636862
37ALK1.39994708
38TYRO31.39318968
39RPS6KB21.38395046
40PIM11.38047896
41JAK31.37709909
42FGFR41.37208984
43PLK31.33770376
44EIF2AK11.33389544
45ZAP701.32372194
46BRSK21.32355363
47VRK11.28983971
48STK31.25236225
49CDK191.22061721
50TXK1.21104500
51AURKB1.19832484
52IKBKB1.16017590
53IRAK41.14112908
54EIF2AK31.13790829
55IRAK31.12716424
56MAP3K141.09235449
57CDC42BPA1.07245499
58VRK21.06158171
59MAP3K81.02083017
60PIM20.99025412
61ATM0.97691326
62CDK20.97558203
63FLT30.93164487
64MTOR0.86364106
65BTK0.85732710
66IKBKE0.84480269
67TAOK20.81899566
68CDK60.81881939
69FES0.81505274
70BLK0.81051948
71GRK60.80728726
72CDK30.79767060
73SIK30.79058563
74NME20.79057280
75MAP2K30.78803401
76AURKA0.77783623
77TGFBR10.77360028
78MAP3K90.76863583
79MAP2K20.76061406
80TYK20.73895305
81FGR0.72874200
82ZAK0.71303712
83MAPK110.70787172
84STK40.70737536
85CSF1R0.70250538
86MAP3K30.68731587
87LYN0.67599511
88MARK20.66496794
89HCK0.66281797
90SIK20.66177242
91ITK0.65893778
92PAK40.64986925
93RPS6KC10.64313057
94RPS6KL10.64313057
95FGFR20.64061709
96CDK10.63709669
97TNK20.62924963
98FGFR30.61815686
99RPS6KA60.61789030
100MAP3K70.60963197
101CAMK40.60698975
102BRSK10.60603392
103KIT0.59717880
104LCK0.58758863
105HIPK20.58743340
106TEC0.58530068
107TAOK10.57977345
108DYRK20.57428634
109MELK0.56828798
110CDK80.56225456
111TAOK30.55625869
112TBK10.54914807
113EIF2AK20.54866247
114PRKCI0.53028109
115CLK10.51052860
116NEK10.50030693
117MAPK70.48263951
118ERBB30.48103384
119RPS6KA20.47994039
120CSNK2A20.47356266
121SYK0.45988661
122STK160.45878580
123ICK0.45794212
124PNCK0.45782507
125STK240.45619224
126* MAPK140.44845712
127PRKD30.44552668
128AKT30.44216852
129MAP3K60.43925373
130TESK20.43609419
131WNK10.43025609
132MARK30.42981206
133PKN20.42864514
134STK110.42827510
135CAMKK10.42210122
136RPS6KA50.41816258
137CDK90.41432083
138NLK0.41377514
139MATK0.41278200
140MAP3K50.40124033
141* GSK3B0.39567147
142MAPK120.39531440
143PRKCH0.39360654
144PRKDC0.39357286
145* RPS6KA10.38682887
146RPS6KB10.38292432
147PRKD20.38278546
148TLK10.36184855
149CSNK2A10.36083438

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.36125769
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.35879215
3Mismatch repair_Homo sapiens_hsa034302.89751137
4Spliceosome_Homo sapiens_hsa030402.87508299
5RNA transport_Homo sapiens_hsa030132.78190852
6Base excision repair_Homo sapiens_hsa034102.48312095
7Cell cycle_Homo sapiens_hsa041102.47798402
8RNA polymerase_Homo sapiens_hsa030202.42166807
9Homologous recombination_Homo sapiens_hsa034402.27606742
10Fanconi anemia pathway_Homo sapiens_hsa034602.06283486
11One carbon pool by folate_Homo sapiens_hsa006702.05534818
12mRNA surveillance pathway_Homo sapiens_hsa030151.97271541
13Nucleotide excision repair_Homo sapiens_hsa034201.89552313
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.87688853
15Basal transcription factors_Homo sapiens_hsa030221.75375227
16RNA degradation_Homo sapiens_hsa030181.73538774
17p53 signaling pathway_Homo sapiens_hsa041151.69543973
18Pyrimidine metabolism_Homo sapiens_hsa002401.59646544
19Non-homologous end-joining_Homo sapiens_hsa034501.54661688
20Antigen processing and presentation_Homo sapiens_hsa046121.52282786
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.50816203
22Herpes simplex infection_Homo sapiens_hsa051681.46170347
23Epstein-Barr virus infection_Homo sapiens_hsa051691.45520550
24Ribosome_Homo sapiens_hsa030101.44648906
25Primary immunodeficiency_Homo sapiens_hsa053401.41293483
26Proteasome_Homo sapiens_hsa030501.22618826
27Measles_Homo sapiens_hsa051621.21769955
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.20358112
29Viral carcinogenesis_Homo sapiens_hsa052031.17530727
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17162369
31HTLV-I infection_Homo sapiens_hsa051661.16861996
32Chronic myeloid leukemia_Homo sapiens_hsa052201.12032161
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10723994
34MicroRNAs in cancer_Homo sapiens_hsa052061.07649417
35Acute myeloid leukemia_Homo sapiens_hsa052211.06102707
36T cell receptor signaling pathway_Homo sapiens_hsa046601.01707192
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.01490749
38Tuberculosis_Homo sapiens_hsa051520.97750394
39Allograft rejection_Homo sapiens_hsa053300.96536637
40NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95315614
41Legionellosis_Homo sapiens_hsa051340.94740865
42Colorectal cancer_Homo sapiens_hsa052100.92455739
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91626544
44Leishmaniasis_Homo sapiens_hsa051400.90839382
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90646358
46Small cell lung cancer_Homo sapiens_hsa052220.90316984
47Apoptosis_Homo sapiens_hsa042100.90279143
48B cell receptor signaling pathway_Homo sapiens_hsa046620.89963699
49Hepatitis B_Homo sapiens_hsa051610.88959571
50Vitamin B6 metabolism_Homo sapiens_hsa007500.88651430
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88125064
52Notch signaling pathway_Homo sapiens_hsa043300.87867915
53Staphylococcus aureus infection_Homo sapiens_hsa051500.87334723
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84513742
55VEGF signaling pathway_Homo sapiens_hsa043700.84183304
56Graft-versus-host disease_Homo sapiens_hsa053320.82168609
57Thyroid cancer_Homo sapiens_hsa052160.80450191
58Influenza A_Homo sapiens_hsa051640.79052601
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.78879763
60Chemokine signaling pathway_Homo sapiens_hsa040620.78540724
61mTOR signaling pathway_Homo sapiens_hsa041500.78116309
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76085939
63ErbB signaling pathway_Homo sapiens_hsa040120.74915004
64Purine metabolism_Homo sapiens_hsa002300.74577838
65Oocyte meiosis_Homo sapiens_hsa041140.74133904
66Viral myocarditis_Homo sapiens_hsa054160.73283687
67Shigellosis_Homo sapiens_hsa051310.71298882
68Choline metabolism in cancer_Homo sapiens_hsa052310.71065524
69Prolactin signaling pathway_Homo sapiens_hsa049170.70337017
70Hepatitis C_Homo sapiens_hsa051600.70301422
71Renal cell carcinoma_Homo sapiens_hsa052110.70141362
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69518027
73Osteoclast differentiation_Homo sapiens_hsa043800.68421317
74Toxoplasmosis_Homo sapiens_hsa051450.68409278
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.68182780
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67430475
77Other glycan degradation_Homo sapiens_hsa005110.66268871
78Hippo signaling pathway_Homo sapiens_hsa043900.66047382
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65826885
80Basal cell carcinoma_Homo sapiens_hsa052170.64941336
81Prostate cancer_Homo sapiens_hsa052150.63831525
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62557047
83Type I diabetes mellitus_Homo sapiens_hsa049400.61677319
84Pancreatic cancer_Homo sapiens_hsa052120.61110608
85TNF signaling pathway_Homo sapiens_hsa046680.60417294
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59029433
87Hematopoietic cell lineage_Homo sapiens_hsa046400.58896934
88Endometrial cancer_Homo sapiens_hsa052130.58287799
89Inositol phosphate metabolism_Homo sapiens_hsa005620.57615281
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57597983
91FoxO signaling pathway_Homo sapiens_hsa040680.57400774
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57019958
93Systemic lupus erythematosus_Homo sapiens_hsa053220.56619998
94Bladder cancer_Homo sapiens_hsa052190.56153757
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55374426
96Type II diabetes mellitus_Homo sapiens_hsa049300.54277775
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.54049358
98MAPK signaling pathway_Homo sapiens_hsa040100.54017404
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53307064
100Pathways in cancer_Homo sapiens_hsa052000.51693553
101Selenocompound metabolism_Homo sapiens_hsa004500.51055908
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.51051678
103Circadian rhythm_Homo sapiens_hsa047100.50181294
104Non-small cell lung cancer_Homo sapiens_hsa052230.49725382
105Autoimmune thyroid disease_Homo sapiens_hsa053200.49665051
106Dorso-ventral axis formation_Homo sapiens_hsa043200.48868046
107Regulation of autophagy_Homo sapiens_hsa041400.47571601
108Glioma_Homo sapiens_hsa052140.46813155
109Lysine degradation_Homo sapiens_hsa003100.45949251
110Wnt signaling pathway_Homo sapiens_hsa043100.45620377
111Alcoholism_Homo sapiens_hsa050340.45551104
112TGF-beta signaling pathway_Homo sapiens_hsa043500.45512315
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44667218
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44383877
115Asthma_Homo sapiens_hsa053100.43929490
116Adherens junction_Homo sapiens_hsa045200.43504674
117Hedgehog signaling pathway_Homo sapiens_hsa043400.42867274
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.37840243
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.37461761
120Estrogen signaling pathway_Homo sapiens_hsa049150.37338834
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37263957
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34133954

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