KDM3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.80976082
2nuclear pore complex assembly (GO:0051292)5.78293544
3mitotic sister chromatid cohesion (GO:0007064)4.98012699
4histone H3-K36 demethylation (GO:0070544)4.71581593
5* histone H3-K9 demethylation (GO:0033169)4.56648067
6histone H3-K4 trimethylation (GO:0080182)4.53523472
7pore complex assembly (GO:0046931)4.39968533
8* histone lysine demethylation (GO:0070076)4.16886208
9mitotic chromosome condensation (GO:0007076)4.12782486
10* histone demethylation (GO:0016577)4.11868659
11pre-miRNA processing (GO:0031054)3.96465644
12protein localization to kinetochore (GO:0034501)3.96195182
13* negative regulation of histone methylation (GO:0031061)3.96027473
14* regulation of histone H3-K9 methylation (GO:0051570)3.93050310
15mitotic nuclear envelope disassembly (GO:0007077)3.74399461
16phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.74072392
17regulation of centriole replication (GO:0046599)3.72720313
18sister chromatid segregation (GO:0000819)3.72419575
19regulation of RNA export from nucleus (GO:0046831)3.69157173
20protein localization to chromosome, centromeric region (GO:0071459)3.69014155
21regulation of sister chromatid cohesion (GO:0007063)3.68991098
22* protein demethylation (GO:0006482)3.66426971
23* protein dealkylation (GO:0008214)3.66426971
24regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.65089532
25gene silencing by RNA (GO:0031047)3.64896531
26regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.64535056
27stress granule assembly (GO:0034063)3.64068687
28coronary vasculature morphogenesis (GO:0060977)3.63613193
29piRNA metabolic process (GO:0034587)3.61414743
30positive regulation of mitotic sister chromatid separation (GO:1901970)3.60398742
31positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.60398742
32positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.60398742
33regulation of posttranscriptional gene silencing (GO:0060147)3.58868364
34regulation of gene silencing by miRNA (GO:0060964)3.58868364
35regulation of gene silencing by RNA (GO:0060966)3.58868364
36DNA unwinding involved in DNA replication (GO:0006268)3.56255154
37nuclear envelope disassembly (GO:0051081)3.56207964
38membrane disassembly (GO:0030397)3.56207964
39peptidyl-lysine trimethylation (GO:0018023)3.50590583
40heterochromatin organization (GO:0070828)3.49135254
41retrograde transport, vesicle recycling within Golgi (GO:0000301)3.47053987
42DNA geometric change (GO:0032392)3.46442887
43mitotic sister chromatid segregation (GO:0000070)3.44882976
44DNA duplex unwinding (GO:0032508)3.44785650
45protein targeting to Golgi (GO:0000042)3.44196297
46establishment of protein localization to Golgi (GO:0072600)3.43501260
47DNA replication-dependent nucleosome organization (GO:0034723)3.39182314
48DNA replication-dependent nucleosome assembly (GO:0006335)3.39182314
49synaptonemal complex assembly (GO:0007130)3.36333736
50monoubiquitinated protein deubiquitination (GO:0035520)3.32358101
51regulation of histone H3-K27 methylation (GO:0061085)3.31524666
52dosage compensation (GO:0007549)3.30434573
53positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.30200782
54regulation of helicase activity (GO:0051095)3.29514993
55paraxial mesoderm development (GO:0048339)3.24932124
56negative regulation of erythrocyte differentiation (GO:0045647)3.24049742
57positive regulation of chromosome segregation (GO:0051984)3.23362308
58regulation of spindle organization (GO:0090224)3.22510216
59histone H3-K4 methylation (GO:0051568)3.22293950
60mitotic metaphase plate congression (GO:0007080)3.21521535
61translesion synthesis (GO:0019985)3.19396744
62meiotic chromosome segregation (GO:0045132)3.19316897
63interkinetic nuclear migration (GO:0022027)3.18168772
64chromatin assembly (GO:0031497)3.17734623
65cilium or flagellum-dependent cell motility (GO:0001539)3.17008331
66positive regulation of SMAD protein import into nucleus (GO:0060391)3.16049200
67synaptonemal complex organization (GO:0070193)3.15050432
68negative regulation of neurotransmitter secretion (GO:0046929)3.11812434
69metaphase plate congression (GO:0051310)3.11386823
70regulation of mitotic spindle organization (GO:0060236)3.09891778
71positive regulation of gamma-delta T cell activation (GO:0046645)3.08812542
72gene silencing (GO:0016458)3.06452903
73response to muramyl dipeptide (GO:0032495)3.06048685
74protein localization to chromosome (GO:0034502)3.03806201
75regulation of NFAT protein import into nucleus (GO:0051532)3.02860283
76male meiosis (GO:0007140)3.02770715
77DNA conformation change (GO:0071103)3.02601419
78chromosome condensation (GO:0030261)3.01938098
79regulation of centrosome cycle (GO:0046605)3.01520523
80negative regulation of DNA repair (GO:0045738)3.01072102
81regulation of chromosome segregation (GO:0051983)3.00888274
82sister chromatid cohesion (GO:0007062)2.99949116
83RNA stabilization (GO:0043489)2.98414703
84mRNA stabilization (GO:0048255)2.98414703
85determination of adult lifespan (GO:0008340)2.96931828
86attachment of spindle microtubules to kinetochore (GO:0008608)2.93640598
87DNA packaging (GO:0006323)2.93064411
88peptidyl-threonine phosphorylation (GO:0018107)2.92773678
89definitive hemopoiesis (GO:0060216)2.92490031
90regulation of nucleobase-containing compound transport (GO:0032239)2.91407674
91regulation of telomere maintenance via telomerase (GO:0032210)2.90036469
92histone H2A monoubiquitination (GO:0035518)2.89371424
93regulation of protein polyubiquitination (GO:1902914)2.88119720
94kinetochore organization (GO:0051383)2.87820760
95embryonic retina morphogenesis in camera-type eye (GO:0060059)2.85543118
96histone H4-K5 acetylation (GO:0043981)2.84619442
97histone H4-K8 acetylation (GO:0043982)2.84619442
98microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.83652575
99DNA topological change (GO:0006265)2.82917333
100histone H4 deacetylation (GO:0070933)2.82727121
101spindle assembly involved in mitosis (GO:0090307)2.82265564
102nuclear envelope organization (GO:0006998)2.81586220
103regulation of hippo signaling (GO:0035330)2.81385949
104regulation of centrosome duplication (GO:0010824)2.80034556
105chromosome organization involved in meiosis (GO:0070192)2.78226281
106somatic hypermutation of immunoglobulin genes (GO:0016446)2.78121489
107somatic diversification of immune receptors via somatic mutation (GO:0002566)2.78121489
108regulation of DNA endoreduplication (GO:0032875)2.77998080
109cytoplasmic mRNA processing body assembly (GO:0033962)2.77939642
110microtubule nucleation (GO:0007020)2.76783828
111chromatin assembly or disassembly (GO:0006333)2.75743118
112mRNA transport (GO:0051028)2.74888153
113DNA replication initiation (GO:0006270)2.74631561
114meiotic nuclear division (GO:0007126)2.73575544
115NLS-bearing protein import into nucleus (GO:0006607)2.73376203
116establishment of chromosome localization (GO:0051303)2.73347540
117histone deubiquitination (GO:0016578)2.73047790
118centrosome localization (GO:0051642)2.72814050
119* histone lysine methylation (GO:0034968)2.72446781
120peptidyl-threonine modification (GO:0018210)2.71458436
121chromosome segregation (GO:0007059)2.69810922
122regulation of mitotic metaphase/anaphase transition (GO:0030071)2.68722865
123regulation of gene silencing (GO:0060968)2.66047099
124positive regulation of granulocyte differentiation (GO:0030854)2.65158439
125protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.64141679
126histone H4-K16 acetylation (GO:0043984)2.63478424
127spindle checkpoint (GO:0031577)2.63056028
128protein K48-linked deubiquitination (GO:0071108)2.63050432
129ATP-dependent chromatin remodeling (GO:0043044)2.62593601
130* negative regulation of histone modification (GO:0031057)2.61853454
131regulation of DNA methylation (GO:0044030)2.61686238
132* negative regulation of chromatin modification (GO:1903309)2.61302722
133DNA methylation (GO:0006306)2.60464204
134DNA alkylation (GO:0006305)2.60464204
135regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.60092537
136regulation of mitotic sister chromatid segregation (GO:0033047)2.59393352
137activated T cell proliferation (GO:0050798)2.59108875
138Golgi to endosome transport (GO:0006895)2.57977232
139nucleus localization (GO:0051647)2.50744228
140establishment of spindle orientation (GO:0051294)2.50525960
141negative thymic T cell selection (GO:0045060)2.50218136
142negative T cell selection (GO:0043383)2.46712237
143protein localization to Golgi apparatus (GO:0034067)2.46595248
144regulation of gamma-delta T cell differentiation (GO:0045586)2.46558323
145* histone H3-K9 modification (GO:0061647)2.45916651
146Notch signaling involved in heart development (GO:0061314)2.45054626
147regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.43611579
148negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.41996773
149negative regulation of cell killing (GO:0031342)2.41996773
150negative regulation of myotube differentiation (GO:0010832)2.40638847
151* nucleus organization (GO:0006997)2.38508590
152cerebral cortex neuron differentiation (GO:0021895)2.38191400
153oocyte development (GO:0048599)2.38078880
154establishment of nucleus localization (GO:0040023)2.36939934
155positive T cell selection (GO:0043368)2.36744465
156radial glial cell differentiation (GO:0060019)2.36059127
157heart valve formation (GO:0003188)2.35435043
158* regulation of histone methylation (GO:0031060)2.33599141
159regulation of gamma-delta T cell activation (GO:0046643)2.33590402
160positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.33413709
161mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.33413709
162intra-Golgi vesicle-mediated transport (GO:0006891)2.33260368
163neuronal stem cell maintenance (GO:0097150)2.32529058
164protein K11-linked deubiquitination (GO:0035871)2.32290691
165face development (GO:0060324)2.30437987
166regulation of ARF protein signal transduction (GO:0032012)2.28963638
167histone H3 deacetylation (GO:0070932)2.28288885
168pyrimidine dimer repair (GO:0006290)2.27328901
169spermatid nucleus differentiation (GO:0007289)2.26835187
170genitalia morphogenesis (GO:0035112)2.26062230
171embryonic process involved in female pregnancy (GO:0060136)2.25801362
172negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.25524462
173phosphatidylinositol phosphorylation (GO:0046854)2.25286379
174negative regulation of potassium ion transmembrane transport (GO:1901380)2.25280059
175embryonic camera-type eye morphogenesis (GO:0048596)2.25174964
176protein deubiquitination (GO:0016579)2.24506223
177negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.22688377
178regulation of growth hormone secretion (GO:0060123)2.21888066
179labyrinthine layer development (GO:0060711)2.20263960
180* peptidyl-lysine methylation (GO:0018022)2.18441015
181antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.17591109
182camera-type eye morphogenesis (GO:0048593)2.16232734
183epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.15803870
184regulation of granulocyte differentiation (GO:0030852)2.14856284
185glucocorticoid receptor signaling pathway (GO:0042921)2.13153398

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.75998630
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.93195134
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.35199938
4SALL1_21062744_ChIP-ChIP_HESCs_Human4.06911735
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.80534735
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.78133280
7EZH2_22144423_ChIP-Seq_EOC_Human3.44532881
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.17020857
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.00424668
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.78555771
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.44918261
12* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.37724619
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.35865529
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.35865529
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.35865529
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.22367062
17MYC_22102868_ChIP-Seq_BL_Human2.16597318
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.12582578
19RUNX_20019798_ChIP-Seq_JUKART_Human2.11477765
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.11241171
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.04027990
22AR_21909140_ChIP-Seq_LNCAP_Human2.00288221
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.97074552
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.89260203
25ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.87923572
26TP63_19390658_ChIP-ChIP_HaCaT_Human1.86628032
27SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.81330736
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.81317317
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.80193526
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.73290199
31EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.72324381
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71917746
33SOX2_18555785_ChIP-Seq_MESCs_Mouse1.70269062
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.68277037
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.65796743
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.64829771
37NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.61797070
38AR_21572438_ChIP-Seq_LNCaP_Human1.61399458
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61151971
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.59674051
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59667619
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.59295835
43SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57899595
44* KDM2B_26808549_Chip-Seq_JURKAT_Human1.54830276
45ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52631876
46HIF1A_21447827_ChIP-Seq_MCF-7_Human1.52207997
47TP53_16413492_ChIP-PET_HCT116_Human1.49713019
48NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.47407895
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.46945264
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.46870545
51SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.46760003
52NANOG_21062744_ChIP-ChIP_HESCs_Human1.46668209
53TCF3_18692474_ChIP-Seq_MEFs_Mouse1.45042480
54TCF3_18692474_ChIP-Seq_MESCs_Mouse1.44328762
55* FOXO3_23340844_ChIP-Seq_DLD1_Human1.44041104
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41208143
57* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.40622849
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40370697
59CIITA_25753668_ChIP-Seq_RAJI_Human1.40322718
60NFIB_24661679_ChIP-Seq_LUNG_Mouse1.39271486
61TCF4_18268006_ChIP-ChIP_LS174T_Human1.38762534
62HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.38349453
63FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36307814
64* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.34713771
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33173200
66NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.33156107
67SCL_19346495_ChIP-Seq_HPC-7_Human1.32052522
68MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.29512722
69* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28615854
70NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28335240
71TCF7_22412390_ChIP-Seq_EML_Mouse1.28219388
72BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28143316
73* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.27803308
74FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.27344491
75VDR_24787735_ChIP-Seq_THP-1_Human1.26615383
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26428017
77TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25904211
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25865662
79Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.23273880
80SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22399675
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21395545
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21278222
83* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20624177
84POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19891897
85KDM5A_27292631_Chip-Seq_BREAST_Human1.19787396
86RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19732508
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19148195
88YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17281530
89STAT3_23295773_ChIP-Seq_U87_Human1.17016215
90AHR_22903824_ChIP-Seq_MCF-7_Human1.16868827
91MYB_21317192_ChIP-Seq_ERMYB_Mouse1.16558936
92XRN2_22483619_ChIP-Seq_HELA_Human1.15808889
93FOXA2_19822575_ChIP-Seq_HepG2_Human1.15773716
94KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15313303
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15308376
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15308376
97SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.14528252
98WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13374220
99ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13262539
100* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10590552
101KDM2B_26808549_Chip-Seq_K562_Human1.10533454
102TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10381273
103TFEB_21752829_ChIP-Seq_HELA_Human1.09496200
104POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.09420272
105BP1_19119308_ChIP-ChIP_Hs578T_Human1.09258386
106GATA3_27048872_Chip-Seq_THYMUS_Human1.08721187
107ISL1_27105846_Chip-Seq_CPCs_Mouse1.08608297
108GATA2_19941826_ChIP-Seq_K562_Human1.06656377
109FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.06240508
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05246590
111* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04404560
112ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03364015
113ARNT_22903824_ChIP-Seq_MCF-7_Human1.02716477
114TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02415719
115TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.02244502
116POU5F1_16518401_ChIP-PET_MESCs_Mouse1.01991484
117GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01249572
118ELK4_26923725_Chip-Seq_MESODERM_Mouse1.01242855
119CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00988732
120SOX2_18692474_ChIP-Seq_MESCs_Mouse1.00817287
121POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99748536
122SPI1_23127762_ChIP-Seq_K562_Human0.99164428
123SMAD4_21799915_ChIP-Seq_A2780_Human0.97840014
124ELK1_19687146_ChIP-ChIP_HELA_Human0.97834451
125MAF_26560356_Chip-Seq_TH1_Human0.96787413
126IGF1R_20145208_ChIP-Seq_DFB_Human0.96528358
127GBX2_23144817_ChIP-Seq_PC3_Human0.95888731
128STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95349153
129CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94744514
130DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94731458
131GATA1_19941826_ChIP-Seq_K562_Human0.94381611
132CLOCK_20551151_ChIP-Seq_293T_Human0.94246164
133KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94184259
134CHD1_26751641_Chip-Seq_LNCaP_Human0.94057523
135UTX_26944678_Chip-Seq_JUKART_Human0.93549172
136NANOG_18692474_ChIP-Seq_MESCs_Mouse0.93182846
137MYC_18358816_ChIP-ChIP_MESCs_Mouse0.92520134
138RXR_22108803_ChIP-Seq_LS180_Human0.91662855
139IRF8_27001747_Chip-Seq_BMDM_Mouse0.90896664
140EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.90803663
141PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90755496
142TAF15_26573619_Chip-Seq_HEK293_Human0.90569960
143* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90377232
144DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90294949
145MYB_26560356_Chip-Seq_TH1_Human0.89939998
146NCOR1_26117541_ChIP-Seq_K562_Human0.89928857
147TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89891625
148* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88771779
149NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.88450337
150CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87370269
151ZFX_18555785_ChIP-Seq_MESCs_Mouse0.87179694
152* VDR_23849224_ChIP-Seq_CD4+_Human0.86576878
153CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85382367
154KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85233679
155KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84395917
156KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.83763034
157KDM2B_26808549_Chip-Seq_DND41_Human0.82900560
158PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.80590604
159* MYB_26560356_Chip-Seq_TH2_Human0.79170301
160FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.79167579
161NANOG_18692474_ChIP-Seq_MEFs_Mouse0.78582949
162TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78239074
163NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.78216521
164ESR1_15608294_ChIP-ChIP_MCF-7_Human0.77401299
165EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.77354749
166* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.77261690

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.49018329
2MP0010094_abnormal_chromosome_stability3.34257496
3MP0003111_abnormal_nucleus_morphology3.22363556
4MP0003122_maternal_imprinting3.01700370
5MP0003077_abnormal_cell_cycle2.89641568
6MP0010352_gastrointestinal_tract_polyps2.85865607
7MP0008877_abnormal_DNA_methylation2.83507697
8MP0005409_darkened_coat_color2.77183918
9MP0003693_abnormal_embryo_hatching2.62581136
10MP0010307_abnormal_tumor_latency2.60522121
11MP0005076_abnormal_cell_differentiation2.56569073
12MP0004957_abnormal_blastocyst_morpholog2.46676800
13MP0008007_abnormal_cellular_replicative2.40130857
14MP0000569_abnormal_digit_pigmentation2.31852911
15MP0003183_abnormal_peptide_metabolism2.14133307
16MP0003656_abnormal_erythrocyte_physiolo2.12352062
17MP0002653_abnormal_ependyma_morphology2.05104533
18MP0008058_abnormal_DNA_repair2.04636835
19MP0008260_abnormal_autophagy2.03637594
20MP0000350_abnormal_cell_proliferation1.97630518
21MP0000778_abnormal_nervous_system1.94031856
22MP0001730_embryonic_growth_arrest1.91222238
23MP0005394_taste/olfaction_phenotype1.84684057
24MP0005499_abnormal_olfactory_system1.84684057
25MP0002084_abnormal_developmental_patter1.79621321
26MP0004197_abnormal_fetal_growth/weight/1.78722195
27MP0001672_abnormal_embryogenesis/_devel1.77491695
28MP0005380_embryogenesis_phenotype1.77491695
29MP0003221_abnormal_cardiomyocyte_apopto1.75558050
30MP0003705_abnormal_hypodermis_morpholog1.75479349
31MP0001293_anophthalmia1.74955530
32MP0008961_abnormal_basal_metabolism1.69879778
33MP0010030_abnormal_orbit_morphology1.69186798
34MP0002086_abnormal_extraembryonic_tissu1.65308040
35MP0002085_abnormal_embryonic_tissue1.65280283
36MP0003984_embryonic_growth_retardation1.63932621
37MP0009278_abnormal_bone_marrow1.62182337
38MP0002088_abnormal_embryonic_growth/wei1.61953499
39MP0004381_abnormal_hair_follicle1.59160541
40MP0003890_abnormal_embryonic-extraembry1.58961577
41MP0001849_ear_inflammation1.57027872
42MP0004808_abnormal_hematopoietic_stem1.55112716
43* MP0002210_abnormal_sex_determination1.55034607
44MP0000566_synostosis1.54550572
45MP0003121_genomic_imprinting1.53433921
46MP0001697_abnormal_embryo_size1.49816902
47MP0003172_abnormal_lysosome_physiology1.49669407
48* MP0001929_abnormal_gametogenesis1.47526547
49MP0003123_paternal_imprinting1.42820679
50MP0003786_premature_aging1.41576694
51MP0001502_abnormal_circadian_rhythm1.39679372
52MP0003787_abnormal_imprinting1.39588613
53MP0003567_abnormal_fetal_cardiomyocyte1.35362187
54MP0010234_abnormal_vibrissa_follicle1.32645567
55MP0002877_abnormal_melanocyte_morpholog1.32111814
56* MP0001145_abnormal_male_reproductive1.31871113
57MP0002080_prenatal_lethality1.30183376
58MP0006292_abnormal_olfactory_placode1.29898155
59MP0002166_altered_tumor_susceptibility1.29501838
60MP0000371_diluted_coat_color1.29224434
61MP0008932_abnormal_embryonic_tissue1.29113876
62MP0000733_abnormal_muscle_development1.28024839
63MP0003828_pulmonary_edema1.27995323
64MP0002092_abnormal_eye_morphology1.25510035
65MP0002822_catalepsy1.22422602
66* MP0003698_abnormal_male_reproductive1.19162402
67MP0000428_abnormal_craniofacial_morphol1.19009682
68MP0005410_abnormal_fertilization1.18770763
69MP0002009_preneoplasia1.18652963
70MP0002249_abnormal_larynx_morphology1.17754787
71MP0005623_abnormal_meninges_morphology1.16763360
72MP0000432_abnormal_head_morphology1.14133311
73MP0005377_hearing/vestibular/ear_phenot1.10720765
74MP0003878_abnormal_ear_physiology1.10720765
75MP0003935_abnormal_craniofacial_develop1.07482612
76MP0010630_abnormal_cardiac_muscle1.07446641
77* MP0000653_abnormal_sex_gland1.07406066
78MP0009053_abnormal_anal_canal1.04418338
79MP0003566_abnormal_cell_adhesion1.04374860
80MP0005397_hematopoietic_system_phenotyp1.03895146
81MP0001545_abnormal_hematopoietic_system1.03895146
82MP0002928_abnormal_bile_duct1.03334016
83MP0000537_abnormal_urethra_morphology1.03150618
84MP0002697_abnormal_eye_size1.02817113
85MP0003937_abnormal_limbs/digits/tail_de1.02739063
86MP0009703_decreased_birth_body1.02425074
87MP0003941_abnormal_skin_development0.98335654
88MP0003300_gastrointestinal_ulcer0.97405933
89* MP0009115_abnormal_fat_cell0.97232709
90MP0003436_decreased_susceptibility_to0.96988356
91MP0002925_abnormal_cardiovascular_devel0.96304558
92MP0002398_abnormal_bone_marrow0.95856894
93MP0001879_abnormal_lymphatic_vessel0.95287368
94MP0002405_respiratory_system_inflammati0.94967288
95MP0000703_abnormal_thymus_morphology0.93534145
96MP0001851_eye_inflammation0.92685333
97MP0000313_abnormal_cell_death0.92623163
98MP0002396_abnormal_hematopoietic_system0.90691428
99MP0000490_abnormal_crypts_of0.90421277
100MP0003950_abnormal_plasma_membrane0.90381678
101MP0002019_abnormal_tumor_incidence0.89334380
102MP0004264_abnormal_extraembryonic_tissu0.89094755
103MP0005187_abnormal_penis_morphology0.89007032
104MP0003763_abnormal_thymus_physiology0.88725334
105MP0008789_abnormal_olfactory_epithelium0.87009952
106MP0003119_abnormal_digestive_system0.86986832
107MP0001915_intracranial_hemorrhage0.86552063
108MP0002075_abnormal_coat/hair_pigmentati0.86544650
109MP0003755_abnormal_palate_morphology0.86291944
110MP0005367_renal/urinary_system_phenotyp0.85282092
111MP0000516_abnormal_urinary_system0.85282092
112MP0003115_abnormal_respiratory_system0.85234277
113MP0005023_abnormal_wound_healing0.85145053
114MP0003453_abnormal_keratinocyte_physiol0.85100088
115MP0001800_abnormal_humoral_immune0.84800895
116MP0003699_abnormal_female_reproductive0.84098163
117MP0010678_abnormal_skin_adnexa0.83906968
118MP0008995_early_reproductive_senescence0.83483579
119MP0002722_abnormal_immune_system0.82199059
120MP0004811_abnormal_neuron_physiology0.82163911
121MP0003283_abnormal_digestive_organ0.81780362
122MP0005248_abnormal_Harderian_gland0.81371508
123MP0002111_abnormal_tail_morphology0.81194180
124MP0003861_abnormal_nervous_system0.81044764
125MP0002006_tumorigenesis0.80211949
126MP0005391_vision/eye_phenotype0.79940081
127MP0001286_abnormal_eye_development0.79312025
128MP0001784_abnormal_fluid_regulation0.78950699
129MP0004859_abnormal_synaptic_plasticity0.78693959
130MP0003690_abnormal_glial_cell0.78531520
131MP0002152_abnormal_brain_morphology0.76673360
132MP0005451_abnormal_body_composition0.75853999
133MP0005257_abnormal_intraocular_pressure0.75830663
134MP0003303_peritoneal_inflammation0.75543933
135MP0004233_abnormal_muscle_weight0.74357868
136MP0005621_abnormal_cell_physiology0.73946700
137* MP0002161_abnormal_fertility/fecundity0.72815422
138MP0004947_skin_inflammation0.72127565
139MP0002132_abnormal_respiratory_system0.71954550
140MP0003315_abnormal_perineum_morphology0.71220368
141MP0003091_abnormal_cell_migration0.71088314
142MP0003329_amyloid_beta_deposits0.70249186
143MP0004484_altered_response_of0.70206872
144MP0000383_abnormal_hair_follicle0.70152218
145MP0000015_abnormal_ear_pigmentation0.69826864
146MP0009672_abnormal_birth_weight0.69572870
147MP0000955_abnormal_spinal_cord0.68582392
148MP0002638_abnormal_pupillary_reflex0.68341347
149MP0001177_atelectasis0.68218641

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.14631199
2Volvulus (HP:0002580)3.60166999
3Astrocytoma (HP:0009592)3.49057967
4Abnormality of the astrocytes (HP:0100707)3.49057967
5Vertebral arch anomaly (HP:0008438)3.41527876
6Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.17835294
7Glioma (HP:0009733)3.02400739
8Medulloblastoma (HP:0002885)2.96100520
9Colon cancer (HP:0003003)2.89611310
10Neoplasm of the oral cavity (HP:0100649)2.75831442
11Impulsivity (HP:0100710)2.65798675
12Short 4th metacarpal (HP:0010044)2.64452154
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.64452154
14Papilledema (HP:0001085)2.62645349
15Heterotopia (HP:0002282)2.62462970
16Increased nuchal translucency (HP:0010880)2.61955319
17Abnormality of the fingertips (HP:0001211)2.61830867
18Menstrual irregularities (HP:0000858)2.47221173
19Selective tooth agenesis (HP:0001592)2.46760526
20Chromsome breakage (HP:0040012)2.44298788
21Rhabdomyosarcoma (HP:0002859)2.41211493
22Malignant gastrointestinal tract tumors (HP:0006749)2.33691191
23Gastrointestinal carcinoma (HP:0002672)2.33691191
24Proximal placement of thumb (HP:0009623)2.33643326
25Ectopic kidney (HP:0000086)2.31385963
26Agnosia (HP:0010524)2.30970241
27Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.30137330
28Deviation of the thumb (HP:0009603)2.27505198
29Broad alveolar ridges (HP:0000187)2.26606471
30Chromosomal breakage induced by crosslinking agents (HP:0003221)2.26359430
31Biliary tract neoplasm (HP:0100574)2.25678885
32Thyroid carcinoma (HP:0002890)2.24663046
33Flat acetabular roof (HP:0003180)2.22378030
34Eczematoid dermatitis (HP:0000976)2.21828925
35Abnormality of the lower motor neuron (HP:0002366)2.20637884
36Neoplasm of striated muscle (HP:0009728)2.20293899
37Deep palmar crease (HP:0006191)2.19217401
38Aplasia/Hypoplasia of the sternum (HP:0006714)2.13442190
39Supernumerary ribs (HP:0005815)2.11422552
40Supernumerary spleens (HP:0009799)2.10434565
41Prominent nose (HP:0000448)2.09054147
42Abnormality of the labia minora (HP:0012880)2.08849233
43Thickened calvaria (HP:0002684)2.08776125
44Missing ribs (HP:0000921)2.08413511
45Acute myeloid leukemia (HP:0004808)2.06067383
46Anal stenosis (HP:0002025)2.02794356
47Abnormality of chromosome stability (HP:0003220)2.02115157
48Hypoplastic labia majora (HP:0000059)2.00424817
49Hepatoblastoma (HP:0002884)2.00356248
50Truncal obesity (HP:0001956)1.99959931
51Basal cell carcinoma (HP:0002671)1.99674913
52Peripheral hypomyelination (HP:0007182)1.98641997
53Narrow palate (HP:0000189)1.98302201
54Osteomalacia (HP:0002749)1.96917107
55Cubitus valgus (HP:0002967)1.95175624
56Cystic hygroma (HP:0000476)1.95147928
57Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.94889428
58Thick eyebrow (HP:0000574)1.93461224
59Tubulointerstitial nephritis (HP:0001970)1.92738665
60Bladder carcinoma (HP:0002862)1.92027588
61Bladder neoplasm (HP:0009725)1.92027588
62Long eyelashes (HP:0000527)1.90730743
6311 pairs of ribs (HP:0000878)1.90515471
64Spinal muscular atrophy (HP:0007269)1.90132613
65Curly hair (HP:0002212)1.90100884
66Thickened helices (HP:0000391)1.88899080
67Abnormality of the left ventricular outflow tract (HP:0011103)1.88869423
68Subaortic stenosis (HP:0001682)1.88869423
69Absent frontal sinuses (HP:0002688)1.87823065
70Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.87144640
71Abnormality of the radial head (HP:0003995)1.86752775
72Hypopigmentation of the fundus (HP:0007894)1.86220021
73Abnormality of the 4th metacarpal (HP:0010012)1.86211319
74Abnormality of incisor morphology (HP:0011063)1.85450830
75Rib fusion (HP:0000902)1.85081001
76Tapered finger (HP:0001182)1.84982797
77Vitreoretinal degeneration (HP:0000655)1.84929480
78Widely spaced teeth (HP:0000687)1.84704165
79Increased IgE level (HP:0003212)1.83501021
80Supernumerary bones of the axial skeleton (HP:0009144)1.83158570
81Short humerus (HP:0005792)1.82399113
82Skull defect (HP:0001362)1.82127510
83Trigonocephaly (HP:0000243)1.80908838
84Cafe-au-lait spot (HP:0000957)1.80349904
85Lip pit (HP:0100267)1.78667915
86Facial hemangioma (HP:0000329)1.78443151
87Ankle contracture (HP:0006466)1.78341790
88Abnormality of the labia majora (HP:0012881)1.78297758
89Cholecystitis (HP:0001082)1.78000739
90Abnormal gallbladder physiology (HP:0012438)1.78000739
91Bowel incontinence (HP:0002607)1.77888091
92Hyperkalemia (HP:0002153)1.77616494
93Genetic anticipation (HP:0003743)1.77466497
94Slow saccadic eye movements (HP:0000514)1.77366027
95Sandal gap (HP:0001852)1.77132395
96Aplasia/hypoplasia of the humerus (HP:0006507)1.76444699
97Macroorchidism (HP:0000053)1.76087722
98Oligodactyly (hands) (HP:0001180)1.75612405
99Atresia of the external auditory canal (HP:0000413)1.75551394
100Degeneration of anterior horn cells (HP:0002398)1.75471322
101Abnormality of the anterior horn cell (HP:0006802)1.75471322
102Abnormality of chromosome segregation (HP:0002916)1.75187871
103Blue irides (HP:0000635)1.74980898
104Broad thumb (HP:0011304)1.74252862
105Large earlobe (HP:0009748)1.74236416
106Meckel diverticulum (HP:0002245)1.74001559
107Diastasis recti (HP:0001540)1.73409087
108Hypoplastic iliac wings (HP:0002866)1.73290350
109Cutis marmorata (HP:0000965)1.72803543
110Papillary thyroid carcinoma (HP:0002895)1.71776151
111Spontaneous hematomas (HP:0007420)1.71693829
112Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.71551001
113Urethral obstruction (HP:0000796)1.71463932
114Abdominal situs inversus (HP:0003363)1.71177958
115Abnormality of abdominal situs (HP:0011620)1.71177958
116Broad phalanges of the hand (HP:0009768)1.71083520
117Difficulty running (HP:0009046)1.70932620
118Chronic hepatic failure (HP:0100626)1.70807597
119Neoplasm of the heart (HP:0100544)1.70415505
120Subacute progressive viral hepatitis (HP:0006572)1.70372740
121Shawl scrotum (HP:0000049)1.70009962
122Aplasia/Hypoplasia of the uvula (HP:0010293)1.69818421
123Ankyloglossia (HP:0010296)1.69372073
124Amyotrophic lateral sclerosis (HP:0007354)1.68931367
125Patellar aplasia (HP:0006443)1.68393515
126Low anterior hairline (HP:0000294)1.67869797
127Skin tags (HP:0010609)1.67739745
128Abnormal hair whorl (HP:0010721)1.66876278
129Myelodysplasia (HP:0002863)1.66721003
130Abnormality of the ileum (HP:0001549)1.65819765
131Abnormality of the carotid arteries (HP:0005344)1.65543248
132Gingivitis (HP:0000230)1.65477477
133Absent radius (HP:0003974)1.65414814
134Excessive salivation (HP:0003781)1.65052365
135Abnormal number of incisors (HP:0011064)1.64882418
136Dislocated radial head (HP:0003083)1.64548653
137Esophageal atresia (HP:0002032)1.64429691
138Deep philtrum (HP:0002002)1.63789231
139Obsessive-compulsive behavior (HP:0000722)1.63495631
140Uterine leiomyosarcoma (HP:0002891)1.63067630
141Leiomyosarcoma (HP:0100243)1.63067630
142Duodenal stenosis (HP:0100867)1.61814974
143Small intestinal stenosis (HP:0012848)1.61814974
144Coarse hair (HP:0002208)1.61693624
145Metaphyseal cupping (HP:0003021)1.61607659
146Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.61471422
147Abnormality of the salivary glands (HP:0010286)1.61462897
148Relative macrocephaly (HP:0004482)1.61460559
149Sloping forehead (HP:0000340)1.59198309
150Chin dimple (HP:0010751)1.59058343
151Gastrointestinal infarctions (HP:0005244)1.58992976
152Broad palm (HP:0001169)1.58717149
153Transitional cell carcinoma of the bladder (HP:0006740)1.58459557
154Abnormality of the pubic bones (HP:0003172)1.58376369
155Abnormality of the distal phalanx of the thumb (HP:0009617)1.58211085
156Short ribs (HP:0000773)1.58145142
157Deeply set eye (HP:0000490)1.57770864
158Gonadotropin excess (HP:0000837)1.57562943
159Intestinal fistula (HP:0100819)1.56984010
160Drooling (HP:0002307)1.56645261
161Germ cell neoplasia (HP:0100728)1.56598956
162Blepharitis (HP:0000498)1.56480823
163Uterine neoplasm (HP:0010784)1.56336303
164Abnormal large intestine physiology (HP:0012700)1.52543583
165Abnormality of the wing of the ilium (HP:0011867)1.51883070
166Obstructive sleep apnea (HP:0002870)1.50434818
167Spinal canal stenosis (HP:0003416)1.49991487
168Hypoplastic ilia (HP:0000946)1.49692714
169Abnormality of the ischium (HP:0003174)1.49533034
170Overlapping toe (HP:0001845)1.48957606
171Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.48793952

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.94341242
2CDC73.73826319
3NEK22.97124225
4EEF2K2.67621312
5WEE12.35597275
6PRPF4B2.24726226
7SIK22.24421309
8TTK2.24260482
9MAP3K102.23299796
10PKN22.15633286
11BRD42.12815406
12KSR22.03222278
13LATS12.00961259
14MAP3K131.99308006
15ATR1.86603302
16STK101.83084090
17CDK61.80073034
18PASK1.73069305
19CDK41.71719773
20EPHA21.70852665
21SGK21.69680566
22RPS6KB21.68413860
23KSR11.67821180
24STK31.65493583
25MAP3K21.59032833
26PDK31.54804051
27PDK41.54804051
28FGFR41.54343579
29MAP3K61.53269435
30CHEK11.51195093
31MARK21.50665528
32SGK2231.49344311
33SGK4941.49344311
34RET1.46265889
35BUB11.45058223
36PLK11.44813943
37SRPK11.43666886
38MELK1.42547613
39NTRK21.40398247
40NLK1.37297061
41CDK71.32261521
42DYRK31.32149812
43EPHA31.32022479
44CHEK21.30817487
45NEK61.30006051
46MTOR1.28343039
47ATM1.28336341
48AURKB1.25560826
49TYRO31.24037536
50NEK11.23984486
51CDK91.23511770
52TSSK61.16437131
53FGFR31.14006743
54ICK1.12416482
55ACVR1B1.12257781
56MAP3K91.11812767
57SIK31.11358427
58PLK31.09949237
59RIPK11.08875465
60FGFR11.06007239
61CAMK1D1.05067072
62MAP3K81.04766978
63DYRK1B1.04362596
64PDK21.02819435
65PDGFRA1.02155188
66STK41.00657860
67CDK21.00238614
68EPHB10.99041175
69TNIK0.98410507
70ALK0.97491651
71PIM10.96062845
72STK380.95914194
73MAP3K140.94727825
74PNCK0.93875590
75TGFBR10.92549580
76CHUK0.90958845
77RPS6KA40.89377992
78CSK0.88634171
79BCR0.87330372
80RIPK40.86760525
81BLK0.85289383
82AKT30.85117513
83JAK20.84585758
84TRIB30.83698748
85MKNK10.79627577
86PAK40.79575526
87FES0.79474975
88BMX0.78499000
89CDK10.78317660
90IRAK10.76992904
91DYRK1A0.76901964
92FLT30.76865871
93BTK0.76240979
94PTK60.76067714
95SCYL20.74426557
96MAP3K40.74415332
97TAOK30.74084853
98SGK10.73944253
99PDGFRB0.72282497
100CDK30.72216942
101RAF10.70981679
102CSNK1D0.70586693
103PRKD30.70561343
104FGFR20.69948339
105HCK0.69907934
106CDK190.68894011
107MKNK20.68713527
108UHMK10.67284939
109YES10.67041002
110DDR20.66915622
111BRSK20.66005613
112IKBKE0.65584875
113MARK30.64784180
114STK240.64312254
115CAMK1G0.64128849
116JAK10.63427608
117ERBB20.61665906
118MARK10.61631005
119CAMKK10.61102495
120MOS0.60696411
121ERBB30.60439500
122NEK90.59328219
123ITK0.59051983
124CAMK40.58751375
125ZAP700.56847011
126PRKDC0.56454223
127MAP3K10.56089100
128PAK20.53894604
129TGFBR20.53815118
130MAPK140.53700080
131SYK0.51506945
132PLK40.51071904
133MAP2K30.50856089
134NTRK30.50779352
135MET0.50707948
136MAP2K40.49753291
137PDK10.49208414
138TRPM70.49029035
139TTN0.48938732
140MAPK150.48808435
141AKT10.48647605
142PIK3CA0.48510571
143MAPK70.48329011
144GSK3B0.47673073
145STK38L0.46746836
146MAPK10.46172728
147MAPK100.45563762
148TNK20.44198064
149EIF2AK30.42909384
150TYK20.42606103
151SIK10.41608784
152SGK30.41081298
153WNK10.40874758
154BMPR20.40684807
155MAPK110.40328175
156LCK0.39328592
157AURKA0.38706227
158TESK10.38566087
159MAP4K10.38469653
160AKT20.37853512
161MAPK80.36822777
162RPS6KB10.36493629
163ZAK0.36366329
164LRRK20.36107283
165CSNK1E0.35874053
166MAP3K70.34570777
167CSNK2A20.33198666

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.96777255
2Mismatch repair_Homo sapiens_hsa034302.86877984
3RNA transport_Homo sapiens_hsa030132.64560063
4Cell cycle_Homo sapiens_hsa041102.60839322
5DNA replication_Homo sapiens_hsa030302.51708043
6Fanconi anemia pathway_Homo sapiens_hsa034602.36953832
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.36815912
8mRNA surveillance pathway_Homo sapiens_hsa030152.33945032
9Spliceosome_Homo sapiens_hsa030402.26357539
10Homologous recombination_Homo sapiens_hsa034401.90895379
11Base excision repair_Homo sapiens_hsa034101.67048596
12Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.66258794
13One carbon pool by folate_Homo sapiens_hsa006701.62686312
14Non-homologous end-joining_Homo sapiens_hsa034501.60692275
15p53 signaling pathway_Homo sapiens_hsa041151.60152724
16Adherens junction_Homo sapiens_hsa045201.59516117
17ErbB signaling pathway_Homo sapiens_hsa040121.57625770
18MicroRNAs in cancer_Homo sapiens_hsa052061.57208621
19Nucleotide excision repair_Homo sapiens_hsa034201.56809265
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54321093
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.48548322
22Choline metabolism in cancer_Homo sapiens_hsa052311.43877957
23RNA degradation_Homo sapiens_hsa030181.41821206
24mTOR signaling pathway_Homo sapiens_hsa041501.39746939
25Basal cell carcinoma_Homo sapiens_hsa052171.39576101
26Viral carcinogenesis_Homo sapiens_hsa052031.38869800
27Basal transcription factors_Homo sapiens_hsa030221.38331242
28Small cell lung cancer_Homo sapiens_hsa052221.35534941
29HTLV-I infection_Homo sapiens_hsa051661.34650522
30Notch signaling pathway_Homo sapiens_hsa043301.33340627
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.32710331
32Herpes simplex infection_Homo sapiens_hsa051681.30658768
33Chronic myeloid leukemia_Homo sapiens_hsa052201.30347754
34Antigen processing and presentation_Homo sapiens_hsa046121.27097038
35Colorectal cancer_Homo sapiens_hsa052101.24868728
36Lysine degradation_Homo sapiens_hsa003101.24793100
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.24648362
38Dorso-ventral axis formation_Homo sapiens_hsa043201.24048654
39Hippo signaling pathway_Homo sapiens_hsa043901.23927065
40Oocyte meiosis_Homo sapiens_hsa041141.23817861
41Type II diabetes mellitus_Homo sapiens_hsa049301.21302558
42TGF-beta signaling pathway_Homo sapiens_hsa043501.18314261
43Systemic lupus erythematosus_Homo sapiens_hsa053221.14326988
44Carbohydrate digestion and absorption_Homo sapiens_hsa049731.14030050
45Thyroid hormone signaling pathway_Homo sapiens_hsa049191.13026841
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.06595000
47Phospholipase D signaling pathway_Homo sapiens_hsa040721.05007826
48Epstein-Barr virus infection_Homo sapiens_hsa051691.04426138
49Prostate cancer_Homo sapiens_hsa052151.02158124
50Endometrial cancer_Homo sapiens_hsa052131.01952642
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01205247
52T cell receptor signaling pathway_Homo sapiens_hsa046600.97954841
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97371728
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.96640273
55Long-term potentiation_Homo sapiens_hsa047200.95458972
56Insulin signaling pathway_Homo sapiens_hsa049100.90142710
57Chemokine signaling pathway_Homo sapiens_hsa040620.90039371
58Measles_Homo sapiens_hsa051620.89379221
59Proteoglycans in cancer_Homo sapiens_hsa052050.88693044
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88471977
61Hepatitis B_Homo sapiens_hsa051610.87203021
62GnRH signaling pathway_Homo sapiens_hsa049120.86549214
63FoxO signaling pathway_Homo sapiens_hsa040680.85951788
64Non-small cell lung cancer_Homo sapiens_hsa052230.84770160
65HIF-1 signaling pathway_Homo sapiens_hsa040660.84126699
66Hedgehog signaling pathway_Homo sapiens_hsa043400.83749404
67Pathways in cancer_Homo sapiens_hsa052000.82703988
68B cell receptor signaling pathway_Homo sapiens_hsa046620.80908150
69Legionellosis_Homo sapiens_hsa051340.80445953
70Thyroid cancer_Homo sapiens_hsa052160.80226588
71Platelet activation_Homo sapiens_hsa046110.78967556
72Pancreatic cancer_Homo sapiens_hsa052120.78138803
73MAPK signaling pathway_Homo sapiens_hsa040100.77291503
74Wnt signaling pathway_Homo sapiens_hsa043100.76794157
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76415359
76Axon guidance_Homo sapiens_hsa043600.75350822
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74688000
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.74617325
79Influenza A_Homo sapiens_hsa051640.74425484
80Ras signaling pathway_Homo sapiens_hsa040140.71961501
81Bladder cancer_Homo sapiens_hsa052190.70422067
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70348209
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70338957
84Viral myocarditis_Homo sapiens_hsa054160.69346833
85Apoptosis_Homo sapiens_hsa042100.69330382
86Cholinergic synapse_Homo sapiens_hsa047250.68509767
87Renal cell carcinoma_Homo sapiens_hsa052110.68207999
88Rap1 signaling pathway_Homo sapiens_hsa040150.66061768
89Long-term depression_Homo sapiens_hsa047300.65884180
90Selenocompound metabolism_Homo sapiens_hsa004500.65689822
91Hepatitis C_Homo sapiens_hsa051600.65242768
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65088820
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64512516
94Primary immunodeficiency_Homo sapiens_hsa053400.63806498
95Gap junction_Homo sapiens_hsa045400.63759408
96Toxoplasmosis_Homo sapiens_hsa051450.63600540
97Acute myeloid leukemia_Homo sapiens_hsa052210.63037862
98Osteoclast differentiation_Homo sapiens_hsa043800.62453696
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60338175
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59239463
101Focal adhesion_Homo sapiens_hsa045100.59100377
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58641032
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58572316
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57840493
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.55832645
106Tight junction_Homo sapiens_hsa045300.55753538
107Endocytosis_Homo sapiens_hsa041440.53269929
108Leishmaniasis_Homo sapiens_hsa051400.51789784
109Alcoholism_Homo sapiens_hsa050340.51604304
110cAMP signaling pathway_Homo sapiens_hsa040240.51438565
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51099672
112RNA polymerase_Homo sapiens_hsa030200.50595406
113Regulation of autophagy_Homo sapiens_hsa041400.50531360
114Inositol phosphate metabolism_Homo sapiens_hsa005620.50164346
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.49974358
116Glucagon signaling pathway_Homo sapiens_hsa049220.49862801
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49635806
118TNF signaling pathway_Homo sapiens_hsa046680.49031387
119Insulin resistance_Homo sapiens_hsa049310.48576148
120ECM-receptor interaction_Homo sapiens_hsa045120.48224140
121VEGF signaling pathway_Homo sapiens_hsa043700.48144401
122Glioma_Homo sapiens_hsa052140.47923028
123Amoebiasis_Homo sapiens_hsa051460.46767943
124AMPK signaling pathway_Homo sapiens_hsa041520.46550752
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45588298
126Melanogenesis_Homo sapiens_hsa049160.45459567
127Tuberculosis_Homo sapiens_hsa051520.44407145
128Fatty acid biosynthesis_Homo sapiens_hsa000610.43052436
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42910116
130Prolactin signaling pathway_Homo sapiens_hsa049170.42624800
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42040744
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41875981
133Estrogen signaling pathway_Homo sapiens_hsa049150.39940626
134Circadian rhythm_Homo sapiens_hsa047100.39166077
135Hematopoietic cell lineage_Homo sapiens_hsa046400.38558123
136Jak-STAT signaling pathway_Homo sapiens_hsa046300.37930391

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