KDM4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.83510165
2locomotory exploration behavior (GO:0035641)4.70188101
3positive regulation by symbiont of host defense response (GO:0052509)4.62261977
4modulation by symbiont of host defense response (GO:0052031)4.62261977
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.62261977
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.62261977
7positive regulation by organism of defense response of other organism involved in symbiotic interact4.62261977
8modulation by symbiont of host immune response (GO:0052553)4.62261977
9layer formation in cerebral cortex (GO:0021819)4.60896018
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.60889555
11regulation of ARF protein signal transduction (GO:0032012)4.51074968
12positive regulation of gamma-delta T cell activation (GO:0046645)4.49560229
13regulation of short-term neuronal synaptic plasticity (GO:0048172)4.39258182
14arginine catabolic process (GO:0006527)4.37531568
15regulation of ARF GTPase activity (GO:0032312)4.29374490
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.28392224
17negative regulation of cell killing (GO:0031342)4.28392224
18positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.23534752
19negative regulation of erythrocyte differentiation (GO:0045647)4.16288690
20positive regulation of synapse maturation (GO:0090129)4.15965294
21dendritic spine morphogenesis (GO:0060997)4.15949194
22regulation of synapse structural plasticity (GO:0051823)4.13332851
23synaptic vesicle exocytosis (GO:0016079)4.10183032
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.05107908
25sodium ion export (GO:0071436)4.00247107
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.92813732
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.86023670
28antigen processing and presentation of endogenous antigen (GO:0019883)3.85415147
29B cell receptor signaling pathway (GO:0050853)3.80280547
30regulation of gamma-delta T cell activation (GO:0046643)3.79963732
31regulation of B cell receptor signaling pathway (GO:0050855)3.77064316
32dendrite morphogenesis (GO:0048813)3.75948432
33vocalization behavior (GO:0071625)3.73543845
34regulation of glutamate receptor signaling pathway (GO:1900449)3.69872736
35macrophage activation involved in immune response (GO:0002281)3.68899478
36detection of other organism (GO:0098543)3.65183935
37detection of bacterium (GO:0016045)3.63365507
38antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.60181337
39response to muramyl dipeptide (GO:0032495)3.59854530
40protein localization to synapse (GO:0035418)3.58809088
41cell communication by electrical coupling (GO:0010644)3.58276515
42regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.56823474
43regulation of synaptic vesicle exocytosis (GO:2000300)3.55495913
44synaptic vesicle docking involved in exocytosis (GO:0016081)3.54368531
45exploration behavior (GO:0035640)3.53122099
46positive regulation of dendritic spine morphogenesis (GO:0061003)3.47760188
47regulation of gamma-delta T cell differentiation (GO:0045586)3.42979454
48cell migration in hindbrain (GO:0021535)3.41775288
49positive regulation of histone deacetylation (GO:0031065)3.41327571
50cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.36033421
51glutamate secretion (GO:0014047)3.34462059
52positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.33989662
53histone H3-K36 demethylation (GO:0070544)3.31988000
54cellular potassium ion homeostasis (GO:0030007)3.30509335
55pyrimidine nucleobase catabolic process (GO:0006208)3.29671062
56regulation of interferon-beta biosynthetic process (GO:0045357)3.27953140
57response to pheromone (GO:0019236)3.27394836
58prepulse inhibition (GO:0060134)3.27342816
59detection of external biotic stimulus (GO:0098581)3.27017993
60detection of molecule of bacterial origin (GO:0032490)3.26596268
61regulation of dendritic spine morphogenesis (GO:0061001)3.26075673
62positive thymic T cell selection (GO:0045059)3.25026771
63substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.21632579
64substrate-independent telencephalic tangential migration (GO:0021826)3.21632579
65germinal center formation (GO:0002467)3.20528068
66regulation of neuronal synaptic plasticity (GO:0048168)3.19577741
67mannose metabolic process (GO:0006013)3.18927839
68axonal fasciculation (GO:0007413)3.18307207
69activation of protein kinase A activity (GO:0034199)3.15347137
70negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.14599083
71thymic T cell selection (GO:0045061)3.13861494
72neuromuscular process controlling balance (GO:0050885)3.13549730
73glial cell proliferation (GO:0014009)3.12883393
74innervation (GO:0060384)3.11172161
75negative regulation of microtubule polymerization (GO:0031115)3.07615304
76regulation of long-term neuronal synaptic plasticity (GO:0048169)3.06705619
77neuron recognition (GO:0008038)3.06300993
78citrulline metabolic process (GO:0000052)3.05719214
79establishment of nucleus localization (GO:0040023)3.05100455
80neurotransmitter-gated ion channel clustering (GO:0072578)3.04619158
81cytoskeletal anchoring at plasma membrane (GO:0007016)3.04532291
82neurotransmitter secretion (GO:0007269)3.03836585
83regulation of p38MAPK cascade (GO:1900744)3.02365509
84positive regulation of protein deacetylation (GO:0090312)3.01884829
85positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.01694423
86negative regulation of cytosolic calcium ion concentration (GO:0051481)3.00305350
87response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.00207430
88response to host immune response (GO:0052572)3.00207430
89ionotropic glutamate receptor signaling pathway (GO:0035235)3.00072474
90cerebellar Purkinje cell layer development (GO:0021680)2.99995105
91peptidyl-arginine omega-N-methylation (GO:0035247)2.97352336
92positive regulation of dendritic spine development (GO:0060999)2.96519667
93nitric oxide mediated signal transduction (GO:0007263)2.94210445
94histone lysine demethylation (GO:0070076)2.91601253
95axon cargo transport (GO:0008088)2.91139089
96detection of biotic stimulus (GO:0009595)2.90413649
97regulation of synaptic vesicle transport (GO:1902803)2.88076713
98response to peptidoglycan (GO:0032494)2.87133956
99response to interleukin-15 (GO:0070672)2.87043066
100response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.86757868
101response to host (GO:0075136)2.86757868
102response to host defenses (GO:0052200)2.86757868
103central nervous system projection neuron axonogenesis (GO:0021952)2.86292467
104negative regulation of myotube differentiation (GO:0010832)2.86045317
105dendritic spine organization (GO:0097061)2.84896733
106peptidyl-arginine N-methylation (GO:0035246)2.84842910
107peptidyl-arginine methylation (GO:0018216)2.84842910
108positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.84759702
109negative regulation of cell size (GO:0045792)2.83812707
110membrane repolarization (GO:0086009)2.83694060
111negative regulation of lymphocyte mediated immunity (GO:0002707)2.82705149
112mitochondrial fusion (GO:0008053)2.82693940
113dopamine receptor signaling pathway (GO:0007212)2.82514399
114vesicle transport along microtubule (GO:0047496)2.82182268
115cellular extravasation (GO:0045123)2.81304596
116cerebellar Purkinje cell differentiation (GO:0021702)2.81231777
117positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.81149405
118G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.80032692
119histone demethylation (GO:0016577)2.79699700
120leukocyte aggregation (GO:0070486)2.79641980
121synaptic transmission, glutamatergic (GO:0035249)2.77842919
122regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.76139006
123membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.75594007
124T cell selection (GO:0045058)2.74857355
125intracellular estrogen receptor signaling pathway (GO:0030520)2.74115104
126negative regulation of toll-like receptor signaling pathway (GO:0034122)2.74038380
127cell communication involved in cardiac conduction (GO:0086065)2.73916178
128regulation of neuron migration (GO:2001222)2.73656964
129membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.73335463
130negative thymic T cell selection (GO:0045060)2.72325187
131regulation of synapse maturation (GO:0090128)2.72203083
132positive regulation of CREB transcription factor activity (GO:0032793)2.70359341
133positive regulation of synaptic transmission, GABAergic (GO:0032230)2.69579341
134auditory behavior (GO:0031223)2.69103476
135neuron cell-cell adhesion (GO:0007158)2.68654703
136organelle transport along microtubule (GO:0072384)2.68174114
137positive regulation of dendrite development (GO:1900006)2.67922967
138regulation of NFAT protein import into nucleus (GO:0051532)2.67744802
139nucleobase catabolic process (GO:0046113)2.67159224
140adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.66490988
141positive T cell selection (GO:0043368)2.66267315
142proline transport (GO:0015824)2.66143896
143positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.65724385
144positive regulation of Rap GTPase activity (GO:0032854)2.64856868
145glutamate receptor signaling pathway (GO:0007215)2.64548444
146histone H3-K4 trimethylation (GO:0080182)2.64182833
147negative regulation of glial cell proliferation (GO:0060253)2.64156440
148regulation of chromatin binding (GO:0035561)2.63678997
149membrane depolarization during action potential (GO:0086010)2.62335726
150pre-miRNA processing (GO:0031054)2.61639006
151positive regulation of dendrite morphogenesis (GO:0050775)2.61616085
152B cell homeostasis (GO:0001782)2.61509275
153negative regulation of leukocyte mediated immunity (GO:0002704)2.61339004
154nerve growth factor signaling pathway (GO:0038180)2.59445918
155positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.58905231
156striatum development (GO:0021756)2.58118168
157potassium ion homeostasis (GO:0055075)2.55213353
158regulation of membrane repolarization (GO:0060306)2.54876413
159synaptic vesicle endocytosis (GO:0048488)2.54535052
160neuron-neuron synaptic transmission (GO:0007270)2.53618653
161regulation of excitatory postsynaptic membrane potential (GO:0060079)2.53534577
162peptidyl-tyrosine autophosphorylation (GO:0038083)2.53429310
163response to type I interferon (GO:0034340)2.53331300
164positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.52897861
165regulation of skeletal muscle cell differentiation (GO:2001014)2.52584879
166CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.52029316
167antigen processing and presentation via MHC class Ib (GO:0002475)2.51848119
168regulation of macrophage cytokine production (GO:0010935)2.51252503
169negative T cell selection (GO:0043383)2.50486830
1703-UTR-mediated mRNA stabilization (GO:0070935)2.49048054
171JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.47974032
172histone H3-K9 demethylation (GO:0033169)2.47750356
173type I interferon signaling pathway (GO:0060337)2.46268076
174cellular response to type I interferon (GO:0071357)2.46268076
175NIK/NF-kappaB signaling (GO:0038061)2.46180252
176immunoglobulin mediated immune response (GO:0016064)2.45917795
177regulation of T-helper 2 cell differentiation (GO:0045628)2.45586647
178insulin-like growth factor receptor signaling pathway (GO:0048009)2.43890822
179regulation of B cell differentiation (GO:0045577)2.42723208
180protein dealkylation (GO:0008214)2.42252663
181protein demethylation (GO:0006482)2.42252663
182T-helper 1 type immune response (GO:0042088)2.41253787
183response to laminar fluid shear stress (GO:0034616)2.41249641
184positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.40042235
185positive regulation of Cdc42 GTPase activity (GO:0043089)2.39545715
186activation of JUN kinase activity (GO:0007257)2.39230786
187cellular response to interleukin-15 (GO:0071350)2.35786173
188respiratory burst (GO:0045730)2.35539795
189negative regulation of T cell mediated immunity (GO:0002710)2.35304718
190regulation of mast cell degranulation (GO:0043304)2.33783036
191regulation of leukocyte degranulation (GO:0043300)2.33682147
192regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.33449703
193modulation by symbiont of host cellular process (GO:0044068)2.32808831
194negative regulation of interleukin-12 production (GO:0032695)2.32774032
195regulation of myeloid leukocyte mediated immunity (GO:0002886)2.30659643
196macrophage activation (GO:0042116)2.30626133
197modulation by virus of host process (GO:0019054)2.29700594

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.46723565
2EZH2_22144423_ChIP-Seq_EOC_Human4.02772410
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.21490378
4RARB_27405468_Chip-Seq_BRAIN_Mouse2.82425512
5ZFP281_18757296_ChIP-ChIP_E14_Mouse2.61041132
6IKZF1_21737484_ChIP-ChIP_HCT116_Human2.33581920
7KDM2B_26808549_Chip-Seq_K562_Human2.33266014
8* DROSHA_22980978_ChIP-Seq_HELA_Human2.33209605
9EZH2_27294783_Chip-Seq_ESCs_Mouse2.26244097
10* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.25591996
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.22934951
12* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.22877779
13TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18819684
14VDR_24763502_ChIP-Seq_THP-1_Human2.18428183
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.16566799
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.14587390
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.14536989
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.14536989
19KDM2B_26808549_Chip-Seq_DND41_Human2.12405079
20WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.12292917
21DNAJC2_21179169_ChIP-ChIP_NT2_Human2.11912236
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.11691665
23JARID2_20075857_ChIP-Seq_MESCs_Mouse2.10815134
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.09592284
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.09474110
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.06258355
27* MAF_26560356_Chip-Seq_TH1_Human2.05242779
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.04839814
29REST_21632747_ChIP-Seq_MESCs_Mouse2.02801779
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00037693
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.98108225
32EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.97879775
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.94529914
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.92662569
35DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.92180474
36LXR_22292898_ChIP-Seq_THP-1_Human1.91569219
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.90508512
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.88588501
39EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.86060808
40* RACK7_27058665_Chip-Seq_MCF-7_Human1.83315570
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.82601208
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.79935289
43UTX_26944678_Chip-Seq_JUKART_Human1.78653016
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.77459227
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.72620955
46BP1_19119308_ChIP-ChIP_Hs578T_Human1.69666000
47KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.68432552
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.67088646
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66162002
50SCL_19346495_ChIP-Seq_HPC-7_Human1.66000900
51* MAF_26560356_Chip-Seq_TH2_Human1.64019671
52SPI1_23127762_ChIP-Seq_K562_Human1.63955368
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.63887813
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.63866197
55KDM2B_26808549_Chip-Seq_JURKAT_Human1.63373101
56TP63_17297297_ChIP-ChIP_HaCaT_Human1.62419303
57GATA1_19941827_ChIP-Seq_MEL_Mouse1.62391002
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.61013345
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60609459
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.59728189
61TCF7_22412390_ChIP-Seq_EML_Mouse1.58550765
62SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56471102
63RUNX1_22412390_ChIP-Seq_EML_Mouse1.56182089
64KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54684152
65SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54683144
66* MYC_22102868_ChIP-Seq_BL_Human1.54487526
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53692912
68RING1B_27294783_Chip-Seq_NPCs_Mouse1.52045053
69* AR_21572438_ChIP-Seq_LNCaP_Human1.51193017
70* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50651486
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.48411417
72OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.48306832
73RING1B_27294783_Chip-Seq_ESCs_Mouse1.47484870
74CTCF_27219007_Chip-Seq_ERYTHROID_Human1.44894959
75RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.43865064
76CREB1_26743006_Chip-Seq_LNCaP_Human1.41957376
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40724553
78BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39715209
79RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39707396
80FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.39360374
81TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.38908907
82RUNX_20019798_ChIP-Seq_JUKART_Human1.37423199
83CTCF_27219007_Chip-Seq_Bcells_Human1.36372711
84* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34731950
85NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33944070
86GATA1_19941826_ChIP-Seq_K562_Human1.32831164
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32710635
88EED_16625203_ChIP-ChIP_MESCs_Mouse1.30947050
89STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28017599
90RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26254438
91IRF8_27001747_Chip-Seq_BMDM_Mouse1.22614105
92SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20661821
93* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19767271
94* NCOR1_26117541_ChIP-Seq_K562_Human1.18231598
95STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15108761
96P68_20966046_ChIP-Seq_HELA_Human1.14947948
97GBX2_23144817_ChIP-Seq_PC3_Human1.13853293
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13385621
99TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.12465595
100TET1_21490601_ChIP-Seq_MESCs_Mouse1.12065877
101BCOR_27268052_Chip-Seq_Bcells_Human1.10568130
102MYB_26560356_Chip-Seq_TH1_Human1.10455848
103P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10366315
104MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09923720
105CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09595161
106AR_19668381_ChIP-Seq_PC3_Human1.09393398
107ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.07617012
108ESR1_20079471_ChIP-ChIP_T-47D_Human1.06734884
109TP53_20018659_ChIP-ChIP_R1E_Mouse1.05036662
110CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04090825
111BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03967595
112GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02811845
113BCL6_27268052_Chip-Seq_Bcells_Human1.02692497
114RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00900310
115ELK3_25401928_ChIP-Seq_HUVEC_Human1.00893385
116RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99697365
117SMC4_20622854_ChIP-Seq_HELA_Human0.99222351
118RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99203168
119RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98971291
120PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98934737
121MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.97831959
122UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97764397
123ELF1_20517297_ChIP-Seq_JURKAT_Human0.97051061
124TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96297769
125PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95958673
126VDR_21846776_ChIP-Seq_THP-1_Human0.95837183
127ELK4_26923725_Chip-Seq_MESODERM_Mouse0.95484790
128STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.95431307
129ZNF263_19887448_ChIP-Seq_K562_Human0.95345653
130ISL1_27105846_Chip-Seq_CPCs_Mouse0.95263856
131NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94678578
132KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92892734
133STAT4_19710469_ChIP-ChIP_TH1__Mouse0.92805788
134KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92512648
135TET1_21451524_ChIP-Seq_MESCs_Mouse0.92253368
136SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.92151475
137IRF8_21731497_ChIP-ChIP_J774_Mouse0.91845400
138* TP63_22573176_ChIP-Seq_HFKS_Human0.91371223
139NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91273350
140PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91240125
141TP53_23651856_ChIP-Seq_MEFs_Mouse0.91111218
142SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88391505
143* OCT4_19829295_ChIP-Seq_ESCs_Human0.88337989
144SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.88088289
145SOX2_21211035_ChIP-Seq_LN229_Gbm0.87541188
146TP53_22127205_ChIP-Seq_IMR90_Human0.87184400
147SA1_27219007_Chip-Seq_ERYTHROID_Human0.86709243
148SMAD4_21741376_ChIP-Seq_ESCs_Human0.85974825
149SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85477994
150AHR_22903824_ChIP-Seq_MCF-7_Human0.84421417
151SMAD3_21741376_ChIP-Seq_HESCs_Human0.84271228
152* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.83941921
153RUNX1_27514584_Chip-Seq_MCF-7_Human0.82787237
154SMAD4_21741376_ChIP-Seq_HESCs_Human0.82476732

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.59865520
2MP0003303_peritoneal_inflammation3.64252571
3MP0003436_decreased_susceptibility_to3.53481711
4MP0003635_abnormal_synaptic_transmissio3.34047158
5MP0009780_abnormal_chondrocyte_physiolo3.08431418
6MP0004270_analgesia3.07886314
7MP0000685_abnormal_immune_system2.81717664
8MP0002063_abnormal_learning/memory/cond2.75265423
9MP0008961_abnormal_basal_metabolism2.69695635
10MP0005423_abnormal_somatic_nervous2.66405984
11MP0003300_gastrointestinal_ulcer2.62468885
12MP0003283_abnormal_digestive_organ2.60812043
13MP0005387_immune_system_phenotype2.57839818
14MP0001790_abnormal_immune_system2.57839818
15MP0001800_abnormal_humoral_immune2.56836454
16MP0002822_catalepsy2.52903088
17MP0003880_abnormal_central_pattern2.48212462
18MP0003724_increased_susceptibility_to2.43031782
19MP0009278_abnormal_bone_marrow2.39695867
20MP0009745_abnormal_behavioral_response2.31796298
21MP0001835_abnormal_antigen_presentation2.29809276
22MP0005451_abnormal_body_composition2.28454153
23MP0003172_abnormal_lysosome_physiology2.24235611
24MP0003763_abnormal_thymus_physiology2.20935649
25MP0008260_abnormal_autophagy2.19522362
26MP0004858_abnormal_nervous_system2.15238251
27MP0005000_abnormal_immune_tolerance2.12486941
28MP0000778_abnormal_nervous_system2.12445177
29MP0002909_abnormal_adrenal_gland2.07906623
30MP0002572_abnormal_emotion/affect_behav2.04675437
31MP0002064_seizures2.04373850
32MP0004811_abnormal_neuron_physiology2.04050409
33MP0002419_abnormal_innate_immunity2.01246708
34MP0004885_abnormal_endolymph2.01099159
35MP0004381_abnormal_hair_follicle1.97595469
36MP0005025_abnormal_response_to1.97177526
37MP0002090_abnormal_vision1.96484145
38MP0005671_abnormal_response_to1.95217909
39MP0002723_abnormal_immune_serum1.94347833
40MP0000569_abnormal_digit_pigmentation1.92943522
41MP0002420_abnormal_adaptive_immunity1.92411986
42MP0001819_abnormal_immune_cell1.90107225
43MP0002452_abnormal_antigen_presenting1.88309531
44MP0008569_lethality_at_weaning1.83176369
45MP0002184_abnormal_innervation1.82263475
46MP0009046_muscle_twitch1.81565818
47MP0002837_dystrophic_cardiac_calcinosis1.74344487
48MP0001486_abnormal_startle_reflex1.72894354
49MP0004947_skin_inflammation1.71441099
50MP0003329_amyloid_beta_deposits1.71369490
51MP0000955_abnormal_spinal_cord1.71299301
52MP0002396_abnormal_hematopoietic_system1.70205141
53MP0000751_myopathy1.69606042
54MP0002398_abnormal_bone_marrow1.65761096
55MP0005409_darkened_coat_color1.63517378
56MP0002734_abnormal_mechanical_nocicepti1.63102548
57MP0005310_abnormal_salivary_gland1.61272692
58MP0003091_abnormal_cell_migration1.59585382
59MP0002272_abnormal_nervous_system1.58803501
60MP0002557_abnormal_social/conspecific_i1.56775528
61MP0000716_abnormal_immune_system1.56446466
62MP0003045_fibrosis1.53743507
63MP0005499_abnormal_olfactory_system1.51974349
64MP0005394_taste/olfaction_phenotype1.51974349
65MP0002733_abnormal_thermal_nociception1.50805201
66MP0002653_abnormal_ependyma_morphology1.49472201
67MP0002882_abnormal_neuron_morphology1.47237802
68MP0003705_abnormal_hypodermis_morpholog1.46064990
69MP0001533_abnormal_skeleton_physiology1.42785967
70MP0004510_myositis1.41844394
71MP0002405_respiratory_system_inflammati1.39852389
72MP0001502_abnormal_circadian_rhythm1.36009190
73MP0002067_abnormal_sensory_capabilities1.35629177
74MP0002009_preneoplasia1.35432795
75MP0004233_abnormal_muscle_weight1.34467137
76MP0000703_abnormal_thymus_morphology1.34198477
77MP0002751_abnormal_autonomic_nervous1.33381712
78MP0002152_abnormal_brain_morphology1.32672177
79MP0002254_reproductive_system_inflammat1.32670760
80MP0001958_emphysema1.30740204
81MP0001970_abnormal_pain_threshold1.29296836
82MP0000537_abnormal_urethra_morphology1.26843534
83MP0003879_abnormal_hair_cell1.25633861
84MP0002722_abnormal_immune_system1.23460034
85MP0001968_abnormal_touch/_nociception1.23229156
86MP0005187_abnormal_penis_morphology1.22703598
87MP0003137_abnormal_impulse_conducting1.22668662
88MP0005386_behavior/neurological_phenoty1.22667030
89MP0004924_abnormal_behavior1.22667030
90MP0010155_abnormal_intestine_physiology1.22548526
91MP0003191_abnormal_cellular_cholesterol1.21742986
92MP0002429_abnormal_blood_cell1.21074687
93MP0002234_abnormal_pharynx_morphology1.20980877
94MP0003828_pulmonary_edema1.20500825
95MP0003122_maternal_imprinting1.19770666
96MP0001348_abnormal_lacrimal_gland1.16740984
97MP0000689_abnormal_spleen_morphology1.16332354
98MP0009785_altered_susceptibility_to1.15103958
99MP0001440_abnormal_grooming_behavior1.14367518
100MP0002066_abnormal_motor_capabilities/c1.13542919
101MP0004084_abnormal_cardiac_muscle1.13424659
102MP0010030_abnormal_orbit_morphology1.10721503
103MP0003566_abnormal_cell_adhesion1.10576991
104MP0001873_stomach_inflammation1.10340505
105MP0002998_abnormal_bone_remodeling1.10296819
106MP0001984_abnormal_olfaction1.09704890
107MP0004808_abnormal_hematopoietic_stem1.09110459
108MP0002933_joint_inflammation1.08903851
109MP0002166_altered_tumor_susceptibility1.08848012
110MP0003861_abnormal_nervous_system1.07926214
111MP0003183_abnormal_peptide_metabolism1.06643559
112MP0003279_aneurysm1.06578580
113MP0005397_hematopoietic_system_phenotyp1.05696575
114MP0001545_abnormal_hematopoietic_system1.05696575
115MP0005058_abnormal_lysosome_morphology1.04108868
116MP0003633_abnormal_nervous_system1.03979081
117MP0002249_abnormal_larynx_morphology1.03955894
118MP0008789_abnormal_olfactory_epithelium1.03047764
119MP0000678_abnormal_parathyroid_gland1.02323145
120MP0003115_abnormal_respiratory_system1.01991337
121MP0000013_abnormal_adipose_tissue1.01385940
122MP0003634_abnormal_glial_cell0.99737961
123MP0004130_abnormal_muscle_cell0.98950871
124MP0004264_abnormal_extraembryonic_tissu0.98769404
125MP0000767_abnormal_smooth_muscle0.98351540
126MP0003866_abnormal_defecation0.98202413
127MP0010234_abnormal_vibrissa_follicle0.96347937
128MP0005551_abnormal_eye_electrophysiolog0.96305892
129MP0001845_abnormal_inflammatory_respons0.95815244
130MP0009333_abnormal_splenocyte_physiolog0.95666324
131MP0008770_decreased_survivor_rate0.94935600
132MP0005623_abnormal_meninges_morphology0.94779552
133MP0003567_abnormal_fetal_cardiomyocyte0.94403680
134MP0003787_abnormal_imprinting0.94094688
135MP0005666_abnormal_adipose_tissue0.92813196
136MP0000631_abnormal_neuroendocrine_gland0.91680675
137MP0005248_abnormal_Harderian_gland0.90988683
138MP0005464_abnormal_platelet_physiology0.90063617
139MP0000747_muscle_weakness0.89706289
140MP0004085_abnormal_heartbeat0.88838764
141MP0004215_abnormal_myocardial_fiber0.88725885
142MP0005076_abnormal_cell_differentiation0.88440581
143MP0000428_abnormal_craniofacial_morphol0.87390372
144MP0004185_abnormal_adipocyte_glucose0.87232150
145MP0001851_eye_inflammation0.87090728
146MP0003119_abnormal_digestive_system0.86363518
147MP0005375_adipose_tissue_phenotype0.86132749
148MP0000858_altered_metastatic_potential0.85960523
149MP0002089_abnormal_postnatal_growth/wei0.85252054
150MP0002735_abnormal_chemical_nociception0.83952517
151MP0003453_abnormal_keratinocyte_physiol0.83528212
152MP0002069_abnormal_eating/drinking_beha0.83366580
153MP0004087_abnormal_muscle_fiber0.81834572
154MP0003631_nervous_system_phenotype0.80729887
155MP0004145_abnormal_muscle_electrophysio0.78883325
156MP0003935_abnormal_craniofacial_develop0.78688676
157MP0001501_abnormal_sleep_pattern0.78180293
158MP0008874_decreased_physiological_sensi0.77413754
159MP0004883_abnormal_blood_vessel0.77182761
160MP0002138_abnormal_hepatobiliary_system0.76912681
161MP0006072_abnormal_retinal_apoptosis0.76370875
162MP0006276_abnormal_autonomic_nervous0.76070951
163MP0001849_ear_inflammation0.75281754
164MP0010630_abnormal_cardiac_muscle0.74961715
165MP0005083_abnormal_biliary_tract0.74850708
166MP0002752_abnormal_somatic_nervous0.74822819
167MP0002106_abnormal_muscle_physiology0.74538982
168MP0002148_abnormal_hypersensitivity_rea0.74529251
169MP0005390_skeleton_phenotype0.73693465
170MP0000003_abnormal_adipose_tissue0.73204396
171MP0002132_abnormal_respiratory_system0.73157609
172MP0002081_perinatal_lethality0.71902202
173MP0003878_abnormal_ear_physiology0.71236495
174MP0005377_hearing/vestibular/ear_phenot0.71236495
175MP0002229_neurodegeneration0.71076858
176MP0005645_abnormal_hypothalamus_physiol0.69475665
177MP0001663_abnormal_digestive_system0.67577260
178MP0003690_abnormal_glial_cell0.67179059
179MP0003948_abnormal_gas_homeostasis0.66851418
180MP0009115_abnormal_fat_cell0.65655633
181MP0009931_abnormal_skin_appearance0.63244246
182MP0005621_abnormal_cell_physiology0.61322466

Predicted human phenotypes

RankGene SetZ-score
1Progressive cerebellar ataxia (HP:0002073)4.96575152
2Termporal pattern (HP:0011008)4.88181713
3Insidious onset (HP:0003587)4.88181713
4Central scotoma (HP:0000603)4.72718608
5Eczematoid dermatitis (HP:0000976)4.37158404
6Peritonitis (HP:0002586)4.00993717
7Myokymia (HP:0002411)3.86628042
8Visual hallucinations (HP:0002367)3.79789617
9Obstructive sleep apnea (HP:0002870)3.76577943
10Conjugated hyperbilirubinemia (HP:0002908)3.65617689
11Abnormality of the fingertips (HP:0001211)3.59225825
12Cellulitis (HP:0100658)3.46552217
13Hyperacusis (HP:0010780)3.43960937
14Abnormality of the lower motor neuron (HP:0002366)3.36556975
15Increased variability in muscle fiber diameter (HP:0003557)3.29383703
16Elevated erythrocyte sedimentation rate (HP:0003565)3.27099062
17Insomnia (HP:0100785)3.24098855
18Gastrointestinal stroma tumor (HP:0100723)3.15850328
19Increased IgE level (HP:0003212)3.14981261
20Recurrent bacterial skin infections (HP:0005406)3.11107812
21Scotoma (HP:0000575)2.97980561
22Focal motor seizures (HP:0011153)2.95210506
23Recurrent abscess formation (HP:0002722)2.91809055
24Meningitis (HP:0001287)2.89713035
25Mediastinal lymphadenopathy (HP:0100721)2.87985433
26Abnormality of skeletal muscle fiber size (HP:0012084)2.87748858
27Colitis (HP:0002583)2.86647778
28Focal seizures (HP:0007359)2.86285243
29Gastrointestinal infarctions (HP:0005244)2.85170467
30Myositis (HP:0100614)2.76245419
31Centrally nucleated skeletal muscle fibers (HP:0003687)2.74960009
32Elfin facies (HP:0004428)2.74522641
33Abnormality of macrophages (HP:0004311)2.72854711
34Progressive sensorineural hearing impairment (HP:0000408)2.72345746
35Orchitis (HP:0100796)2.72247736
36Depression (HP:0000716)2.71412125
37Annular pancreas (HP:0001734)2.70853214
38Ankle clonus (HP:0011448)2.70676572
39Agammaglobulinemia (HP:0004432)2.67898595
40Pointed chin (HP:0000307)2.67666045
41Neuroendocrine neoplasm (HP:0100634)2.65824547
42Supranuclear gaze palsy (HP:0000605)2.64215078
43Emphysema (HP:0002097)2.64087058
44Broad face (HP:0000283)2.62866126
45Gingivitis (HP:0000230)2.60392829
46Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.59103390
47Spontaneous hematomas (HP:0007420)2.55625572
48Shoulder girdle muscle weakness (HP:0003547)2.55512612
49Retrobulbar optic neuritis (HP:0100654)2.55074797
50Optic neuritis (HP:0100653)2.55074797
51Recurrent gram-negative bacterial infections (HP:0005420)2.52232650
52Epileptic encephalopathy (HP:0200134)2.51667497
53Amyotrophic lateral sclerosis (HP:0007354)2.49443543
54Difficulty running (HP:0009046)2.47762166
55Metaphyseal cupping (HP:0003021)2.47145099
56Recurrent fungal infections (HP:0002841)2.44390716
57Abnormal delayed hypersensitivity skin test (HP:0002963)2.42765680
58Gastrointestinal inflammation (HP:0004386)2.42334118
59Overriding aorta (HP:0002623)2.42040705
60Renovascular hypertension (HP:0100817)2.38016536
61Pheochromocytoma (HP:0002666)2.38015010
62Vasculitis (HP:0002633)2.37565959
63Dyschromatopsia (HP:0007641)2.35275230
64Renal duplication (HP:0000075)2.34877689
65Neoplasm of the heart (HP:0100544)2.33779625
66Action tremor (HP:0002345)2.32744025
67Fatigue (HP:0012378)2.31063031
68Pelvic girdle muscle weakness (HP:0003749)2.31040568
69Long palpebral fissure (HP:0000637)2.29877934
70Amblyopia (HP:0000646)2.29846461
71Lissencephaly (HP:0001339)2.29805312
72Inflammation of the large intestine (HP:0002037)2.28473851
73Macroorchidism (HP:0000053)2.26345910
74Megalencephaly (HP:0001355)2.26262989
75Abnormality of the peritoneum (HP:0002585)2.26228124
76Obstructive lung disease (HP:0006536)2.25434849
77Chronic obstructive pulmonary disease (HP:0006510)2.25434849
78Disproportionate tall stature (HP:0001519)2.25094975
79Abnormality of the astrocytes (HP:0100707)2.24329021
80Astrocytoma (HP:0009592)2.24329021
81Horizontal nystagmus (HP:0000666)2.23120251
82Urinary urgency (HP:0000012)2.20205828
83Recurrent cutaneous fungal infections (HP:0011370)2.19032570
84Chronic mucocutaneous candidiasis (HP:0002728)2.19032570
85Segmental peripheral demyelination/remyelination (HP:0003481)2.18565773
86Increased connective tissue (HP:0009025)2.17437958
87Hypercortisolism (HP:0001578)2.16654611
88Bowel diverticulosis (HP:0005222)2.15119251
89Neoplasm of the peripheral nervous system (HP:0100007)2.14966020
90Deep palmar crease (HP:0006191)2.14443202
91Dysmetric saccades (HP:0000641)2.14106474
92Flat cornea (HP:0007720)2.13531025
93Lower limb amyotrophy (HP:0007210)2.12991515
94Lymphopenia (HP:0001888)2.10730052
95Abnormality of the musculature of the pelvis (HP:0001469)2.10657836
96Abnormality of the hip-girdle musculature (HP:0001445)2.10657836
97Hemiparesis (HP:0001269)2.10308262
98Hypochromic anemia (HP:0001931)2.09523750
99Large eyes (HP:0001090)2.09480560
100Thin bony cortex (HP:0002753)2.08190021
101Ependymoma (HP:0002888)2.07783405
102Restrictive lung disease (HP:0002091)2.07517791
103Hip dysplasia (HP:0001385)2.06965789
104Distal upper limb amyotrophy (HP:0007149)2.06201904
105Upper limb amyotrophy (HP:0009129)2.06201904
106Recurrent skin infections (HP:0001581)2.04853867
107Genetic anticipation (HP:0003743)2.04698925
108Persistence of primary teeth (HP:0006335)2.03951603
109Osteomyelitis (HP:0002754)2.00593069
110Urinary bladder sphincter dysfunction (HP:0002839)2.00196722
111EEG with generalized epileptiform discharges (HP:0011198)1.99464632
112Hemiplegia (HP:0002301)1.98875634
113Generalized tonic-clonic seizures (HP:0002069)1.98621784
114Hypsarrhythmia (HP:0002521)1.98560800
115Chest pain (HP:0100749)1.97922616
116Genu recurvatum (HP:0002816)1.95351349
117Abnormality of cells of the lymphoid lineage (HP:0012140)1.93361759
118Papilloma (HP:0012740)1.92723924
119Verrucae (HP:0200043)1.92723924
120Cerebral inclusion bodies (HP:0100314)1.92306320
121Epileptiform EEG discharges (HP:0011182)1.90796757
122Ventricular fibrillation (HP:0001663)1.90230364
123Abnormal auditory evoked potentials (HP:0006958)1.89896928
124Torticollis (HP:0000473)1.87941586
125Heterotopia (HP:0002282)1.87529520
126Focal dystonia (HP:0004373)1.87333367
127Abnormality of incisor morphology (HP:0011063)1.87258735
128Long eyelashes (HP:0000527)1.86860980
129Impaired social interactions (HP:0000735)1.86782596
130Abnormal social behavior (HP:0012433)1.86782596
131Keratoconjunctivitis sicca (HP:0001097)1.86564524
132Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86391191
133Progressive external ophthalmoplegia (HP:0000590)1.85380822
134Urticaria (HP:0001025)1.84467639
135Progressive hearing impairment (HP:0001730)1.84047194
136Polycythemia (HP:0001901)1.83692011
137Aneurysm (HP:0002617)1.83660228
138Impaired vibration sensation in the lower limbs (HP:0002166)1.83250894
139Sepsis (HP:0100806)1.83244503
140Limb dystonia (HP:0002451)1.83076391
141Onion bulb formation (HP:0003383)1.82832052
142Bronchomalacia (HP:0002780)1.82397268
143Recurrent sinusitis (HP:0011108)1.81598353
144Germ cell neoplasia (HP:0100728)1.81210668
145Encephalitis (HP:0002383)1.81154161
146Impaired pain sensation (HP:0007328)1.80672742
147Abnormality of pain sensation (HP:0010832)1.80672742
148Neonatal hypoglycemia (HP:0001998)1.80334411
149Recurrent viral infections (HP:0004429)1.80187941
150Dysdiadochokinesis (HP:0002075)1.79121561
151Shallow orbits (HP:0000586)1.77501190
152Supernumerary ribs (HP:0005815)1.76932618
153Slow saccadic eye movements (HP:0000514)1.76693978
154Abnormality of the distal phalanx of the thumb (HP:0009617)1.76481925
155Hand muscle atrophy (HP:0009130)1.75572438
156Prolonged bleeding time (HP:0003010)1.75519983
157Dilatation of the ascending aorta (HP:0005111)1.75234780
158Drooling (HP:0002307)1.73866611
159Excessive salivation (HP:0003781)1.73866611
160Rapidly progressive (HP:0003678)1.73431821
161Visceral angiomatosis (HP:0100761)1.73341606
162Lower limb muscle weakness (HP:0007340)1.72898763
163Impaired smooth pursuit (HP:0007772)1.72097618
164Agitation (HP:0000713)1.71801978
165Spastic gait (HP:0002064)1.71649388
166Mitral valve prolapse (HP:0001634)1.71453344
167Poor eye contact (HP:0000817)1.71050053
168Hemoptysis (HP:0002105)1.70868876
169Arterial thrombosis (HP:0004420)1.70365664
170Megalocornea (HP:0000485)1.70126909
171Renal tubular acidosis (HP:0001947)1.69861988
172Cerebral aneurysm (HP:0004944)1.69461720
173Bladder diverticulum (HP:0000015)1.69420416
174Mitral regurgitation (HP:0001653)1.68720157
175Narrow palate (HP:0000189)1.68111851
176Abnormality of the thoracic spine (HP:0100711)1.66941624
177Pulmonary infiltrates (HP:0002113)1.65024696
178Recurrent bronchitis (HP:0002837)1.64854732
179Flat acetabular roof (HP:0003180)1.64035267
180Dislocated radial head (HP:0003083)1.63912072
181Easy fatigability (HP:0003388)1.63612923
182Sparse lateral eyebrow (HP:0005338)1.62012310
183Broad metatarsal (HP:0001783)1.60931161
184Keratoconjunctivitis (HP:0001096)1.60381518
185Lymphangioma (HP:0100764)1.59620847
186Abnormality of the endocardium (HP:0004306)1.59456163
187Abnormality of the radial head (HP:0003995)1.58543135

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.77411612
2EPHA42.88591167
3RIPK42.84963040
4MAP3K92.80507557
5TRIB32.66582329
6MAP4K12.57290820
7MAP3K102.51649784
8NTRK32.34787324
9SMG12.23854172
10EEF2K2.20676722
11PAK62.18925476
12PKN22.14820677
13PRKD31.98458662
14TNK21.95950783
15BLK1.92826163
16SIK21.92122603
17ICK1.91175578
18NTRK21.88635116
19MINK11.85416033
20DAPK21.82173771
21CAMKK11.78011229
22IRAK41.73599207
23KSR11.68978946
24MAP2K31.67222938
25TYRO31.66921770
26RIPK11.66831083
27EPHB11.62437457
28MAP3K111.61827401
29PHKG11.61561675
30PHKG21.61561675
31KSR21.57202040
32MAP3K41.56818086
33UHMK11.46156218
34NTRK11.41938330
35NUAK11.40695803
36PDGFRA1.40201172
37CAMK1D1.38802841
38TYK21.37300587
39STK111.25043238
40CSK1.24330698
41PTK61.22057426
42CDK51.21843909
43EPHB21.21622781
44BTK1.18272311
45PRKCH1.16969437
46MAP3K71.16223642
47PRKD21.13826919
48RET1.07673750
49LMTK21.07303838
50HCK1.05359020
51FGFR21.04335502
52MARK21.03584524
53STK381.02878979
54ZAP701.01830274
55TAOK11.00477654
56RPS6KA21.00456825
57ALK0.99308355
58HIPK20.99094044
59CAMK1G0.96716903
60MAPK120.95957986
61MAP3K10.95601235
62DAPK10.95109470
63TTN0.94688992
64LATS20.94558732
65MAP3K140.93890108
66JAK30.92388157
67MAPK130.91711992
68CDC42BPA0.91426982
69CAMK40.90273365
70DDR20.88487235
71SYK0.87811989
72IKBKE0.87495649
73RPS6KC10.87368089
74RPS6KL10.87368089
75JAK20.83350702
76CSF1R0.82924958
77SGK2230.82788346
78SGK4940.82788346
79PDPK10.82006553
80JAK10.81801217
81TBK10.81169323
82PDK10.80807493
83MAP3K60.79938134
84PAK30.78735212
85MTOR0.78608679
86SGK30.76192996
87RPS6KA60.75927862
88EPHA30.74568509
89FES0.74512907
90PRKCZ0.74493438
91TAOK20.74133620
92DYRK30.73201078
93SCYL20.73075681
94PDGFRB0.70714015
95MAPK110.70321700
96WNK10.69728045
97MAP3K30.69653376
98PRPF4B0.65448266
99MAPK70.65219799
100CDK140.65023111
101PRKD10.64843662
102CHUK0.64815504
103SIK30.64771413
104PRKAA10.64173459
105BRD40.62891841
106ERBB20.62459202
107FGR0.61151871
108MAP3K130.60980071
109LYN0.60359666
110SIK10.60262083
111DYRK1B0.59973311
112SGK20.58738427
113FYN0.58440731
114CDK150.58150411
115SGK10.58117532
116MAP2K40.58023239
117MAPK100.57900854
118CDK120.57679604
119GRK60.56305075
120LRRK20.55685199
121LCK0.55034137
122NEK10.54875791
123TLK10.54785462
124CDK180.54660585
125DYRK20.52856444
126AKT30.52459999
127MAPK90.50990121
128RPS6KA30.50503956
129FGFR30.50273967
130CDK11A0.50139926
131BMX0.47335400
132MARK30.47159926
133FGFR10.46567813
134DMPK0.44772676
135MAP3K20.44673877
136MAP2K10.44654640
137CAMK10.43449159
138ITK0.42999245
139FGFR40.41758121
140YES10.41280974
141CAMK2A0.40485572
142ERN10.40237708
143PTK20.40226591
144PRKCB0.40217265
145DYRK1A0.40117529
146PRKCG0.39840365
147IRAK10.39684104
148MAP2K20.39348777
149RPS6KA10.39251634
150IRAK20.38535035

Predicted pathways (KEGG)

RankGene SetZ-score
1Circadian entrainment_Homo sapiens_hsa047132.13966482
2Acute myeloid leukemia_Homo sapiens_hsa052212.03394105
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.02617268
4GABAergic synapse_Homo sapiens_hsa047271.99194545
5Morphine addiction_Homo sapiens_hsa050321.96727293
6Olfactory transduction_Homo sapiens_hsa047401.94268800
7Synaptic vesicle cycle_Homo sapiens_hsa047211.93934724
8Nicotine addiction_Homo sapiens_hsa050331.89709230
9Long-term potentiation_Homo sapiens_hsa047201.89305149
10Osteoclast differentiation_Homo sapiens_hsa043801.86196721
11Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.83732914
12Leishmaniasis_Homo sapiens_hsa051401.79367015
13Glutamatergic synapse_Homo sapiens_hsa047241.78150753
14Insulin secretion_Homo sapiens_hsa049111.76302927
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75170681
16Dopaminergic synapse_Homo sapiens_hsa047281.72147815
17Cholinergic synapse_Homo sapiens_hsa047251.69086708
18Amphetamine addiction_Homo sapiens_hsa050311.68159000
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.67140405
20Cocaine addiction_Homo sapiens_hsa050301.63530037
21Renin secretion_Homo sapiens_hsa049241.54446850
22Type II diabetes mellitus_Homo sapiens_hsa049301.53953413
23Oxytocin signaling pathway_Homo sapiens_hsa049211.51607948
24Salivary secretion_Homo sapiens_hsa049701.49353511
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.44228968
26Gap junction_Homo sapiens_hsa045401.44088603
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40732669
28Dilated cardiomyopathy_Homo sapiens_hsa054141.37774710
29Gastric acid secretion_Homo sapiens_hsa049711.37571968
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32706499
31Dorso-ventral axis formation_Homo sapiens_hsa043201.31983441
32Staphylococcus aureus infection_Homo sapiens_hsa051501.31789120
33Estrogen signaling pathway_Homo sapiens_hsa049151.31591341
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.31543500
35Glioma_Homo sapiens_hsa052141.30811397
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30554185
37Axon guidance_Homo sapiens_hsa043601.30419695
38mTOR signaling pathway_Homo sapiens_hsa041501.28752138
39Allograft rejection_Homo sapiens_hsa053301.28127794
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.25291865
41Primary immunodeficiency_Homo sapiens_hsa053401.23864381
42Endometrial cancer_Homo sapiens_hsa052131.23830534
43Pancreatic cancer_Homo sapiens_hsa052121.23690999
44Tuberculosis_Homo sapiens_hsa051521.23387578
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.23227042
46Graft-versus-host disease_Homo sapiens_hsa053321.22702103
47Autoimmune thyroid disease_Homo sapiens_hsa053201.22049010
48Toxoplasmosis_Homo sapiens_hsa051451.21252366
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.19988576
50Chemokine signaling pathway_Homo sapiens_hsa040621.19541615
51GnRH signaling pathway_Homo sapiens_hsa049121.19112436
52Thyroid hormone signaling pathway_Homo sapiens_hsa049191.17859885
53Influenza A_Homo sapiens_hsa051641.16274344
54Phospholipase D signaling pathway_Homo sapiens_hsa040721.15592449
55Central carbon metabolism in cancer_Homo sapiens_hsa052301.14751843
56Measles_Homo sapiens_hsa051621.14324539
57Neurotrophin signaling pathway_Homo sapiens_hsa047221.14313690
58Colorectal cancer_Homo sapiens_hsa052101.14117684
59Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13385689
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.12561153
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.12399384
62NF-kappa B signaling pathway_Homo sapiens_hsa040641.12121136
63VEGF signaling pathway_Homo sapiens_hsa043701.11132953
64cAMP signaling pathway_Homo sapiens_hsa040241.10885541
65Taste transduction_Homo sapiens_hsa047421.10041411
66Melanogenesis_Homo sapiens_hsa049161.09650738
67Other glycan degradation_Homo sapiens_hsa005111.09183525
68Hepatitis B_Homo sapiens_hsa051611.09057770
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.08101901
70Long-term depression_Homo sapiens_hsa047301.07411737
71Intestinal immune network for IgA production_Homo sapiens_hsa046721.06251631
72cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04466085
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02670435
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00983290
75TNF signaling pathway_Homo sapiens_hsa046681.00153027
76Hepatitis C_Homo sapiens_hsa051601.00135953
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99631213
78ErbB signaling pathway_Homo sapiens_hsa040120.99472857
79Calcium signaling pathway_Homo sapiens_hsa040200.99315622
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.97267545
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96744344
82Non-small cell lung cancer_Homo sapiens_hsa052230.96389251
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95712242
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.95332647
85Glucagon signaling pathway_Homo sapiens_hsa049220.95253443
86Renal cell carcinoma_Homo sapiens_hsa052110.93758742
87Platelet activation_Homo sapiens_hsa046110.93358451
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.92928103
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92804772
90Prostate cancer_Homo sapiens_hsa052150.92783233
91Insulin signaling pathway_Homo sapiens_hsa049100.92724687
92Malaria_Homo sapiens_hsa051440.92487582
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92205403
94FoxO signaling pathway_Homo sapiens_hsa040680.92108240
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91265839
96Serotonergic synapse_Homo sapiens_hsa047260.86088685
97Chronic myeloid leukemia_Homo sapiens_hsa052200.84183766
98Nitrogen metabolism_Homo sapiens_hsa009100.83520588
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.83079927
100Insulin resistance_Homo sapiens_hsa049310.83038130
101Apoptosis_Homo sapiens_hsa042100.82863127
102Viral carcinogenesis_Homo sapiens_hsa052030.82066725
103Endocytosis_Homo sapiens_hsa041440.81511410
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81198389
105Herpes simplex infection_Homo sapiens_hsa051680.80992062
106Choline metabolism in cancer_Homo sapiens_hsa052310.77554847
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.77483141
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.77215677
109MAPK signaling pathway_Homo sapiens_hsa040100.76396017
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75568148
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75264654
112Notch signaling pathway_Homo sapiens_hsa043300.75221294
113Alcoholism_Homo sapiens_hsa050340.74595169
114AMPK signaling pathway_Homo sapiens_hsa041520.73558842
115Bladder cancer_Homo sapiens_hsa052190.73378969
116Type I diabetes mellitus_Homo sapiens_hsa049400.71197492
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71101228
118Rap1 signaling pathway_Homo sapiens_hsa040150.69164570
119HTLV-I infection_Homo sapiens_hsa051660.68742072
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68126428
121Amoebiasis_Homo sapiens_hsa051460.67376876
122Thyroid hormone synthesis_Homo sapiens_hsa049180.66825999
123Oocyte meiosis_Homo sapiens_hsa041140.63517134
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62963467
125Basal cell carcinoma_Homo sapiens_hsa052170.62709611
126Lysine degradation_Homo sapiens_hsa003100.62601529
127Pancreatic secretion_Homo sapiens_hsa049720.62204102
128Systemic lupus erythematosus_Homo sapiens_hsa053220.61043591
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60965883
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60670374
131MicroRNAs in cancer_Homo sapiens_hsa052060.60342509
132Thyroid cancer_Homo sapiens_hsa052160.57802046
133Hippo signaling pathway_Homo sapiens_hsa043900.57646029
134Small cell lung cancer_Homo sapiens_hsa052220.57121739
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56767489
136Hematopoietic cell lineage_Homo sapiens_hsa046400.55746907
137Cardiac muscle contraction_Homo sapiens_hsa042600.55450134
138Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54884848
139Circadian rhythm_Homo sapiens_hsa047100.54184948
140Focal adhesion_Homo sapiens_hsa045100.53258993
141Prolactin signaling pathway_Homo sapiens_hsa049170.53006590
142B cell receptor signaling pathway_Homo sapiens_hsa046620.52688140
143Wnt signaling pathway_Homo sapiens_hsa043100.51587524
144HIF-1 signaling pathway_Homo sapiens_hsa040660.51575914
145Proteoglycans in cancer_Homo sapiens_hsa052050.49957282
146Hedgehog signaling pathway_Homo sapiens_hsa043400.49790156
147Viral myocarditis_Homo sapiens_hsa054160.49276790
148Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48515527
149Bile secretion_Homo sapiens_hsa049760.48182812
150T cell receptor signaling pathway_Homo sapiens_hsa046600.48178149
151Inositol phosphate metabolism_Homo sapiens_hsa005620.46996432

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