KDM4D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)9.25123832
2spermatid nucleus differentiation (GO:0007289)8.32298167
3protein localization to kinetochore (GO:0034501)7.26112928
4metaphase plate congression (GO:0051310)7.02201676
5negative regulation of hormone biosynthetic process (GO:0032353)6.90240764
6negative regulation of hormone metabolic process (GO:0032351)6.90240764
7maturation of 5.8S rRNA (GO:0000460)6.80419618
8nuclear pore complex assembly (GO:0051292)6.43125899
9regulation of establishment of cell polarity (GO:2000114)6.25139101
10protein localization to chromosome, centromeric region (GO:0071459)6.20782586
11microtubule depolymerization (GO:0007019)6.19211906
12synapsis (GO:0007129)6.00738144
13regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.95508653
14acrosome assembly (GO:0001675)5.83528816
15negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.69626190
16myoblast migration (GO:0051451)5.63099725
17negative regulation of keratinocyte proliferation (GO:0010839)5.57993620
18monoubiquitinated protein deubiquitination (GO:0035520)5.54554499
19establishment of chromosome localization (GO:0051303)5.52207278
20regulation of spindle organization (GO:0090224)5.48798683
21regulation of exit from mitosis (GO:0007096)5.26632345
22ovulation from ovarian follicle (GO:0001542)5.23073054
23regulation of glucocorticoid metabolic process (GO:0031943)5.19499331
24regulation of establishment or maintenance of cell polarity (GO:0032878)5.08944264
25nuclear pore organization (GO:0006999)5.00865581
26regulation of mitotic spindle organization (GO:0060236)4.93927785
27negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.88666619
28meiosis I (GO:0007127)4.83492284
29chromosome organization involved in meiosis (GO:0070192)4.69884503
30oocyte maturation (GO:0001556)4.60310325
31pore complex assembly (GO:0046931)4.57804760
32microtubule polymerization or depolymerization (GO:0031109)4.56383832
33nucleus organization (GO:0006997)4.51778347
34DNA ligation (GO:0006266)4.49858480
35DNA synthesis involved in DNA repair (GO:0000731)4.41067548
36piRNA metabolic process (GO:0034587)4.38464624
37resolution of meiotic recombination intermediates (GO:0000712)4.29228925
38positive regulation of chromosome segregation (GO:0051984)4.24848978
39male meiosis I (GO:0007141)4.24535146
40proteasome assembly (GO:0043248)4.23594073
41regulation of retinoic acid receptor signaling pathway (GO:0048385)4.20354077
42deoxyribose phosphate biosynthetic process (GO:0046385)4.05884332
432-deoxyribonucleotide biosynthetic process (GO:0009265)4.05884332
44protein localization to chromosome (GO:0034502)4.05360104
45maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.02450569
46DNA strand elongation involved in DNA replication (GO:0006271)4.00020471
47telomere maintenance via semi-conservative replication (GO:0032201)3.94223827
48DNA double-strand break processing (GO:0000729)3.92561318
49kinetochore organization (GO:0051383)3.92411048
50modulation by virus of host process (GO:0019054)3.92074507
51deoxyribonucleotide biosynthetic process (GO:0009263)3.87840007
52mitotic sister chromatid segregation (GO:0000070)3.86554809
53DNA strand elongation (GO:0022616)3.85767995
54meiotic chromosome segregation (GO:0045132)3.85550189
55positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.82783941
56positive regulation of mitotic sister chromatid separation (GO:1901970)3.82783941
57positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.82783941
58cellular response to electrical stimulus (GO:0071257)3.82121207
59regulation of transcription from RNA polymerase I promoter (GO:0006356)3.77448736
60regulation of meiosis I (GO:0060631)3.76179773
61histone exchange (GO:0043486)3.73821195
62regulation of RNA export from nucleus (GO:0046831)3.72527159
63regulation of telomere maintenance via telomerase (GO:0032210)3.69524711
64negative regulation by host of viral transcription (GO:0043922)3.69454038
65kinetochore assembly (GO:0051382)3.65673031
66regulation of double-strand break repair via homologous recombination (GO:0010569)3.64630245
67meiotic nuclear division (GO:0007126)3.61450532
68DNA replication checkpoint (GO:0000076)3.59817186
69regulation of steroid hormone biosynthetic process (GO:0090030)3.58764554
70binding of sperm to zona pellucida (GO:0007339)3.54872255
71poly(A)+ mRNA export from nucleus (GO:0016973)3.54652962
72attachment of spindle microtubules to kinetochore (GO:0008608)3.53933105
73glycosylceramide metabolic process (GO:0006677)3.52525304
74negative regulation of receptor-mediated endocytosis (GO:0048261)3.51531556
75meiotic cell cycle process (GO:1903046)3.47117684
76DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.43887335
77CENP-A containing nucleosome assembly (GO:0034080)3.41309927
78DNA damage response, signal transduction resulting in transcription (GO:0042772)3.41079608
79modulation by symbiont of host cellular process (GO:0044068)3.39269336
80regulation of centriole replication (GO:0046599)3.34933177
81DNA replication-independent nucleosome assembly (GO:0006336)3.33665130
82DNA replication-independent nucleosome organization (GO:0034724)3.33665130
83DNA methylation involved in gamete generation (GO:0043046)3.33564473
84spindle checkpoint (GO:0031577)3.31707636
85establishment of mitotic spindle localization (GO:0040001)3.31412408
86negative regulation of alcohol biosynthetic process (GO:1902931)3.29926716
87nucleotide-excision repair, DNA gap filling (GO:0006297)3.29673220
88sister chromatid segregation (GO:0000819)3.29033225
89regulation of nucleobase-containing compound transport (GO:0032239)3.28820416
90chromatin remodeling at centromere (GO:0031055)3.25983104
91replication fork processing (GO:0031297)3.25181009
92sister chromatid cohesion (GO:0007062)3.24496904
93mitotic recombination (GO:0006312)3.23625357
94positive regulation of megakaryocyte differentiation (GO:0045654)3.22606087
95negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.22284211
96chromosome segregation (GO:0007059)3.20663831
97regulation of chromosome segregation (GO:0051983)3.20630043
98telomere maintenance via recombination (GO:0000722)3.20432612
99DNA catabolic process, exonucleolytic (GO:0000738)3.18736857
100synaptonemal complex assembly (GO:0007130)3.18622064
101mitotic spindle checkpoint (GO:0071174)3.17961657
102negative regulation of DNA-dependent DNA replication (GO:2000104)3.17403682
103leukocyte tethering or rolling (GO:0050901)3.17177609
104male meiosis (GO:0007140)3.14371636
105regulation of keratinocyte differentiation (GO:0045616)3.12933136
106anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.12772882
107centriole replication (GO:0007099)3.12570923
108inner cell mass cell proliferation (GO:0001833)3.10413182
109synaptonemal complex organization (GO:0070193)3.09956443
110negative regulation of chromosome segregation (GO:0051985)3.07955433
111female gonad development (GO:0008585)3.07421800
112negative regulation of mitotic sister chromatid separation (GO:2000816)3.06313122
113negative regulation of sister chromatid segregation (GO:0033046)3.06313122
114negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.06313122
115negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.06313122
116negative regulation of mitotic sister chromatid segregation (GO:0033048)3.06313122
117ATP-dependent chromatin remodeling (GO:0043044)3.05503093
118histone H2A monoubiquitination (GO:0035518)3.04898145
119establishment of integrated proviral latency (GO:0075713)3.04702563
120negative regulation of steroid biosynthetic process (GO:0010894)3.03492233
121negative regulation of fatty acid biosynthetic process (GO:0045717)3.03083770
122cullin deneddylation (GO:0010388)3.00641120
123mRNA modification (GO:0016556)3.00036211
124hyperosmotic salinity response (GO:0042538)3.00022117
125telomere maintenance via telomere lengthening (GO:0010833)2.99886639
126positive regulation of catecholamine secretion (GO:0033605)2.99482621
127NLS-bearing protein import into nucleus (GO:0006607)2.99416412
128regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.96251051
129mitotic spindle assembly checkpoint (GO:0007094)2.96177029
130regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.95922393
131mitotic nuclear envelope disassembly (GO:0007077)2.94152812
132rRNA transcription (GO:0009303)2.93683433
133regulation of mitochondrial translation (GO:0070129)2.93401619
134non-recombinational repair (GO:0000726)2.93333253
135double-strand break repair via nonhomologous end joining (GO:0006303)2.93333253
136negative regulation of peptidyl-lysine acetylation (GO:2000757)2.92475839
137spindle assembly checkpoint (GO:0071173)2.91695147
138chromosome organization (GO:0051276)2.90113451
139nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.89949980
140serine family amino acid biosynthetic process (GO:0009070)2.89173402
141regulation of centrosome cycle (GO:0046605)2.88316583
142regulation of mitotic metaphase/anaphase transition (GO:0030071)2.87285787
143regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.87285787
144inositol phosphate catabolic process (GO:0071545)2.86949725
145positive regulation of protein import into nucleus, translocation (GO:0033160)2.85947668
146mitotic chromosome condensation (GO:0007076)2.84288468
147negative regulation of fibroblast apoptotic process (GO:2000270)2.84066096
148organelle disassembly (GO:1903008)2.83688892
149chromosome condensation (GO:0030261)2.83259349
150vitamin transmembrane transport (GO:0035461)2.83206544
151regulation of keratinocyte proliferation (GO:0010837)2.82214599
152regulation of DNA methylation (GO:0044030)2.82160228
153negative regulation of steroid metabolic process (GO:0045939)2.82106644
154acrosome reaction (GO:0007340)2.80938118
155spermatid development (GO:0007286)2.80804929
156ribosome biogenesis (GO:0042254)2.80591570
157negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.79063540
158DNA replication initiation (GO:0006270)2.78998386
159sperm-egg recognition (GO:0035036)2.78294081
160phosphorylated carbohydrate dephosphorylation (GO:0046838)2.78166315
161positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.78098849
162meiotic cell cycle (GO:0051321)2.77218629
163regulation of sister chromatid segregation (GO:0033045)2.75610691
164regulation of mitotic sister chromatid separation (GO:0010965)2.75610691
165regulation of mitotic sister chromatid segregation (GO:0033047)2.75610691
166translesion synthesis (GO:0019985)2.75263508
167DNA biosynthetic process (GO:0071897)2.75239019
168DNA replication-dependent nucleosome assembly (GO:0006335)2.72957040
169DNA replication-dependent nucleosome organization (GO:0034723)2.72957040

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.97433935
2E2F7_22180533_ChIP-Seq_HELA_Human7.53875750
3FOXM1_23109430_ChIP-Seq_U2OS_Human7.52314929
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.59965778
5KAP1_22055183_ChIP-Seq_ESCs_Mouse4.04153907
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.99169703
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.51218143
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.43422460
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.36197225
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.31302473
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.23773232
12AR_21909140_ChIP-Seq_LNCAP_Human3.15949282
13E2F4_17652178_ChIP-ChIP_JURKAT_Human3.07899957
14MYC_18555785_ChIP-Seq_MESCs_Mouse3.03971165
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.86401381
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.80324737
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.50542267
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.50420085
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.47757232
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.47727504
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.38528883
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.36532622
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.33251931
24* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.30877031
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28555777
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22412474
27DCP1A_22483619_ChIP-Seq_HELA_Human2.20683199
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.14897968
29ELK1_19687146_ChIP-ChIP_HELA_Human2.11726519
30MYC_18358816_ChIP-ChIP_MESCs_Mouse2.11547833
31KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.10067840
32MYC_19030024_ChIP-ChIP_MESCs_Mouse2.02045128
33FOXP3_21729870_ChIP-Seq_TREG_Human2.01248604
34VDR_23849224_ChIP-Seq_CD4+_Human1.98253802
35TTF2_22483619_ChIP-Seq_HELA_Human1.94987327
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93789707
37GABP_19822575_ChIP-Seq_HepG2_Human1.93237859
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93188778
39EZH2_22144423_ChIP-Seq_EOC_Human1.92421156
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84018979
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81262641
42XRN2_22483619_ChIP-Seq_HELA_Human1.80698145
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.77036238
44SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.76640492
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72063929
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.71706045
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71044519
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69020014
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65627830
50ZNF274_21170338_ChIP-Seq_K562_Hela1.63143185
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.63052981
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62195378
53RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.58125510
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.56522017
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56176742
56IGF1R_20145208_ChIP-Seq_DFB_Human1.51274148
57EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46961066
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.46893358
59EGR1_23403033_ChIP-Seq_LIVER_Mouse1.45363636
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45079799
61TAF15_26573619_Chip-Seq_HEK293_Human1.44495919
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44034520
63GATA1_26923725_Chip-Seq_HPCs_Mouse1.43610701
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40455372
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37834262
66FUS_26573619_Chip-Seq_HEK293_Human1.33997020
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.33824599
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32953127
69FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.30587250
70EWS_26573619_Chip-Seq_HEK293_Human1.29678981
71IRF1_19129219_ChIP-ChIP_H3396_Human1.28325661
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.25295866
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.24667552
74SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.24260330
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24007679
76ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23580167
77TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23142956
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.22257528
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21056156
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.17863748
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17716090
82KDM5A_27292631_Chip-Seq_BREAST_Human1.17154500
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17145712
84RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15242222
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14871161
86STAT3_18555785_ChIP-Seq_MESCs_Mouse1.13143541
87SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12605141
88CREB1_15753290_ChIP-ChIP_HEK293T_Human1.11725675
89KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10759953
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09879783
91NANOG_16153702_ChIP-ChIP_HESCs_Human1.09532400
92ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.09343632
93E2F1_21310950_ChIP-Seq_MCF-7_Human1.09251796
94AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08089208
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06901558
96CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06714960
97PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05298133
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05248094
99SOX2_16153702_ChIP-ChIP_HESCs_Human1.01124615
100RNF2_27304074_Chip-Seq_NSC_Mouse0.99436350
101ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99253655
102PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.98691545
103NOTCH1_21737748_ChIP-Seq_TLL_Human0.97557841
104PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97279312
105RUNX1_26923725_Chip-Seq_HPCs_Mouse0.96394654
106CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.96279422
107GF1_26923725_Chip-Seq_HPCs_Mouse0.95980327
108EZH2_27294783_Chip-Seq_NPCs_Mouse0.95605938
109SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95118758
110NFE2_27457419_Chip-Seq_LIVER_Mouse0.95079921
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94330517
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94330517
113CDX2_22108803_ChIP-Seq_LS180_Human0.94118356
114NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94105232
115KAP1_27257070_Chip-Seq_ESCs_Mouse0.91648355
116CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91587525
117RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90828178
118MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90572790
119EGR1_19374776_ChIP-ChIP_THP-1_Human0.90440735
120NANOG_18555785_ChIP-Seq_MESCs_Mouse0.90290611
121CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89599286
122* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89118155
123GBX2_23144817_ChIP-Seq_PC3_Human0.89032637
124ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88995828
125VDR_22108803_ChIP-Seq_LS180_Human0.87986826
126SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.87902949
127STAT1_17558387_ChIP-Seq_HELA_Human0.87646449
128ELK1_22589737_ChIP-Seq_MCF10A_Human0.86673884
129NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.86248458
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85144154
131CTBP2_25329375_ChIP-Seq_LNCAP_Human0.85066857
132ZNF263_19887448_ChIP-Seq_K562_Human0.84364364
133ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84345107
134BMI1_23680149_ChIP-Seq_NPCS_Mouse0.84051795
135JUN_21703547_ChIP-Seq_K562_Human0.82798041
136FOXH1_21741376_ChIP-Seq_EPCs_Human0.82197704
137CBX2_27304074_Chip-Seq_ESCs_Mouse0.81385206
138RXR_22158963_ChIP-Seq_LIVER_Mouse0.80798467
139SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80302115
140* P300_19829295_ChIP-Seq_ESCs_Human0.80170463
141FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.79823289
142DPY_21335234_ChIP-Seq_ESCs_Mouse0.79711320
143ERG_20887958_ChIP-Seq_HPC-7_Mouse0.79180878
144LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78773169
145BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78683697
146TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.78450468
147SOX17_20123909_ChIP-Seq_XEN_Mouse0.78377684
148DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.75808541
149POU5F1_16518401_ChIP-PET_MESCs_Mouse0.75558896
150KLF4_18555785_ChIP-Seq_MESCs_Mouse0.75427935
151ZFP57_27257070_Chip-Seq_ESCs_Mouse0.74255362
152MYC_18940864_ChIP-ChIP_HL60_Human0.73289230
153EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.73025481
154MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.72902283
155TP53_22573176_ChIP-Seq_HFKS_Human0.72261635
156ESET_19884257_ChIP-Seq_ESCs_Mouse0.71009636
157DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.70252295
158EP300_21415370_ChIP-Seq_HL-1_Mouse0.68229061
159AR_25329375_ChIP-Seq_VCAP_Human0.68027084
160LXR_22158963_ChIP-Seq_LIVER_Mouse0.67359271
161TBL1_22424771_ChIP-Seq_293T_Human0.67321494
162CRX_20693478_ChIP-Seq_RETINA_Mouse0.67267535
163PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.65517229
164ESR1_20079471_ChIP-ChIP_T-47D_Human0.65178823
165* GF1B_26923725_Chip-Seq_HPCs_Mouse0.64330627
166OCT4_21477851_ChIP-Seq_ESCs_Mouse0.63831804
167PADI4_21655091_ChIP-ChIP_MCF-7_Human0.63357442
168HOXB7_26014856_ChIP-Seq_BT474_Human0.63209240
169SOX2_18555785_Chip-Seq_ESCs_Mouse0.62602979
170STAT3_23295773_ChIP-Seq_U87_Human0.61513028
171FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.61283996

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.41356690
2MP0003950_abnormal_plasma_membrane4.37967760
3MP0003693_abnormal_embryo_hatching4.21394183
4MP0008007_abnormal_cellular_replicative3.85092449
5MP0008057_abnormal_DNA_replication3.58796622
6MP0010307_abnormal_tumor_latency3.50990577
7MP0008877_abnormal_DNA_methylation3.34456565
8MP0008789_abnormal_olfactory_epithelium3.10313619
9MP0003111_abnormal_nucleus_morphology2.94031364
10MP0005499_abnormal_olfactory_system2.90475717
11MP0005394_taste/olfaction_phenotype2.90475717
12MP0003077_abnormal_cell_cycle2.58715470
13MP0005360_urolithiasis2.55415253
14MP0003136_yellow_coat_color2.52477446
15MP0005076_abnormal_cell_differentiation2.41359843
16MP0002877_abnormal_melanocyte_morpholog2.36044676
17MP0006292_abnormal_olfactory_placode2.36031437
18MP0010030_abnormal_orbit_morphology2.29800503
19MP0004270_analgesia2.18810827
20MP0004859_abnormal_synaptic_plasticity2.06078086
21MP0001730_embryonic_growth_arrest2.03504617
22MP0003787_abnormal_imprinting2.03149760
23MP0005187_abnormal_penis_morphology1.87935492
24MP0001851_eye_inflammation1.87346290
25MP0008995_early_reproductive_senescence1.87216078
26MP0001929_abnormal_gametogenesis1.86902869
27MP0004957_abnormal_blastocyst_morpholog1.84573533
28MP0005365_abnormal_bile_salt1.83092432
29MP0005410_abnormal_fertilization1.82196432
30MP0010094_abnormal_chromosome_stability1.80333333
31MP0000372_irregular_coat_pigmentation1.76139453
32MP0003315_abnormal_perineum_morphology1.75085916
33MP0000566_synostosis1.74670597
34MP0002233_abnormal_nose_morphology1.73529984
35MP0005085_abnormal_gallbladder_physiolo1.72844606
36MP0010234_abnormal_vibrissa_follicle1.71974520
37MP0005647_abnormal_sex_gland1.71636772
38MP0001984_abnormal_olfaction1.66678515
39MP0004885_abnormal_endolymph1.63508172
40MP0002102_abnormal_ear_morphology1.61905913
41MP0004883_abnormal_blood_vessel1.56420079
42MP0002396_abnormal_hematopoietic_system1.54199112
43MP0001293_anophthalmia1.52786778
44MP0003718_maternal_effect1.51529799
45MP0003786_premature_aging1.47107352
46MP0006035_abnormal_mitochondrial_morpho1.46918933
47MP0000350_abnormal_cell_proliferation1.46190942
48MP0002938_white_spotting1.43798556
49MP0002210_abnormal_sex_determination1.43577841
50MP0000653_abnormal_sex_gland1.40191789
51MP0005380_embryogenesis_phenotype1.35862227
52MP0001672_abnormal_embryogenesis/_devel1.35862227
53MP0003122_maternal_imprinting1.35538162
54MP0002234_abnormal_pharynx_morphology1.33727424
55MP0000049_abnormal_middle_ear1.33614733
56MP0004185_abnormal_adipocyte_glucose1.32133692
57MP0003699_abnormal_female_reproductive1.30800207
58MP0003698_abnormal_male_reproductive1.30046605
59MP0009697_abnormal_copulation1.26102823
60MP0006036_abnormal_mitochondrial_physio1.25543352
61MP0001145_abnormal_male_reproductive1.25179568
62MP0001529_abnormal_vocalization1.24944342
63MP0001177_atelectasis1.24668901
64MP0001346_abnormal_lacrimal_gland1.24657776
65MP0005408_hypopigmentation1.24376023
66MP0003890_abnormal_embryonic-extraembry1.23707997
67MP0001119_abnormal_female_reproductive1.23374064
68MP0003937_abnormal_limbs/digits/tail_de1.20549527
69MP0003635_abnormal_synaptic_transmissio1.19880768
70MP0002837_dystrophic_cardiac_calcinosis1.19803399
71MP0003632_abnormal_nervous_system1.19538183
72MP0006276_abnormal_autonomic_nervous1.18892533
73MP0000579_abnormal_nail_morphology1.17575395
74MP0002161_abnormal_fertility/fecundity1.15343110
75MP0003119_abnormal_digestive_system1.11604453
76MP0005310_abnormal_salivary_gland1.06526622
77MP0005388_respiratory_system_phenotype1.05349903
78MP0002133_abnormal_respiratory_system1.05349903
79MP0000627_abnormal_mammary_gland1.04888715
80MP0006072_abnormal_retinal_apoptosis1.04443535
81MP0004233_abnormal_muscle_weight1.02207448
82MP0008875_abnormal_xenobiotic_pharmacok1.01687724
83MP0002163_abnormal_gland_morphology1.01444660
84MP0008058_abnormal_DNA_repair1.00243155
85MP0002085_abnormal_embryonic_tissue0.99114279
86MP0002277_abnormal_respiratory_mucosa0.96678152
87MP0003984_embryonic_growth_retardation0.96101685
88MP0000358_abnormal_cell_content/0.95835570
89MP0001697_abnormal_embryo_size0.95651212
90MP0003123_paternal_imprinting0.95538351
91MP0003705_abnormal_hypodermis_morpholog0.94374022
92MP0000631_abnormal_neuroendocrine_gland0.94171535
93MP0003941_abnormal_skin_development0.94125608
94MP0002084_abnormal_developmental_patter0.92990764
95MP0009672_abnormal_birth_weight0.91488707
96MP0001286_abnormal_eye_development0.90956820
97MP0005389_reproductive_system_phenotype0.90456088
98MP0005391_vision/eye_phenotype0.90235996
99MP0000639_abnormal_adrenal_gland0.89944692
100MP0003868_abnormal_feces_composition0.89572277
101MP0002088_abnormal_embryonic_growth/wei0.88445045
102MP0003385_abnormal_body_wall0.85909682
103MP0002086_abnormal_extraembryonic_tissu0.85608401
104MP0003186_abnormal_redox_activity0.84641909
105MP0000767_abnormal_smooth_muscle0.83927917
106MP0002697_abnormal_eye_size0.83852677
107MP0002092_abnormal_eye_morphology0.83275505
108MP0009046_muscle_twitch0.81597699
109MP0002090_abnormal_vision0.79967211
110MP0005253_abnormal_eye_physiology0.79760825
111MP0005621_abnormal_cell_physiology0.79550788
112MP0008932_abnormal_embryonic_tissue0.78976707
113MP0002254_reproductive_system_inflammat0.78578494
114MP0002249_abnormal_larynx_morphology0.77035676
115MP0001764_abnormal_homeostasis0.76480127
116MP0006138_congestive_heart_failure0.76223726
117MP0000313_abnormal_cell_death0.75620088
118MP0005646_abnormal_pituitary_gland0.75272905
119MP0005248_abnormal_Harderian_gland0.74539514
120MP0005164_abnormal_response_to0.73150601
121MP0005423_abnormal_somatic_nervous0.72745821
122MP0005623_abnormal_meninges_morphology0.72057013
123MP0003936_abnormal_reproductive_system0.71929195
124MP0004264_abnormal_extraembryonic_tissu0.71710434
125MP0000778_abnormal_nervous_system0.71586036
126MP0003861_abnormal_nervous_system0.71539139
127MP0002111_abnormal_tail_morphology0.71246097
128MP0000647_abnormal_sebaceous_gland0.69384605
129MP0005084_abnormal_gallbladder_morpholo0.68766048
130MP0002638_abnormal_pupillary_reflex0.67798568
131MP0004133_heterotaxia0.67320408
132MP0003755_abnormal_palate_morphology0.66727103
133MP0002080_prenatal_lethality0.65953716
134MP0003567_abnormal_fetal_cardiomyocyte0.65405936
135MP0002060_abnormal_skin_morphology0.65295100
136MP0001849_ear_inflammation0.65190587
137MP0000537_abnormal_urethra_morphology0.64304438
138MP0004145_abnormal_muscle_electrophysio0.63640559
139MP0002063_abnormal_learning/memory/cond0.62563757
140MP0005395_other_phenotype0.62124901
141MP0003880_abnormal_central_pattern0.61713571
142MP0002160_abnormal_reproductive_system0.61509156
143MP0003938_abnormal_ear_development0.60361566
144MP0003121_genomic_imprinting0.60134934
145MP0001881_abnormal_mammary_gland0.59479228
146MP0001299_abnormal_eye_distance/0.59281273
147MP0003690_abnormal_glial_cell0.58640321
148MP0000609_abnormal_liver_physiology0.58182869
149MP0003115_abnormal_respiratory_system0.56927249

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)6.45863125
2Papillary thyroid carcinoma (HP:0002895)5.81768666
3Prostate neoplasm (HP:0100787)5.32477353
4Birth length less than 3rd percentile (HP:0003561)5.31842679
5Facial hemangioma (HP:0000329)4.43000292
6Breast hypoplasia (HP:0003187)4.03389075
7Thyroid carcinoma (HP:0002890)3.92639279
8Patellar aplasia (HP:0006443)3.89980331
9Capillary hemangiomas (HP:0005306)3.69734626
10Carpal bone hypoplasia (HP:0001498)3.65468678
11Enlarged penis (HP:0000040)3.60105336
12Mutism (HP:0002300)3.52764904
13Aplasia/Hypoplasia of the patella (HP:0006498)3.51918539
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.48731897
15Abnormal auditory evoked potentials (HP:0006958)3.43491469
16Chromsome breakage (HP:0040012)3.31943722
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.25512744
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.25512744
19Breast aplasia (HP:0100783)3.24049642
20Spontaneous abortion (HP:0005268)3.23667753
21Ankle contracture (HP:0006466)3.17506284
22Gonadotropin excess (HP:0000837)3.14503417
23Abnormality of chromosome stability (HP:0003220)3.09310073
24Shawl scrotum (HP:0000049)3.08964659
25Abnormality of the ileum (HP:0001549)3.03016138
26Aplasia/Hypoplasia of the breasts (HP:0010311)3.00972975
27Male infertility (HP:0003251)2.98089923
28Degeneration of anterior horn cells (HP:0002398)2.96464850
29Abnormality of the anterior horn cell (HP:0006802)2.96464850
30Microvesicular hepatic steatosis (HP:0001414)2.87061190
31Acute lymphatic leukemia (HP:0006721)2.84068957
32Hyperglycinemia (HP:0002154)2.83601798
33Wrist flexion contracture (HP:0001239)2.83389114
34Abnormal lung lobation (HP:0002101)2.82637607
35Abnormality of the prostate (HP:0008775)2.82150339
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.81926710
37Oligodactyly (hands) (HP:0001180)2.79759868
38Abnormal mitochondria in muscle tissue (HP:0008316)2.72892070
39Myocardial infarction (HP:0001658)2.71242592
40Gout (HP:0001997)2.64051714
41Acute necrotizing encephalopathy (HP:0006965)2.59521169
42Sensory axonal neuropathy (HP:0003390)2.55287172
43Duodenal stenosis (HP:0100867)2.54322340
44Small intestinal stenosis (HP:0012848)2.54322340
45Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.54234221
46Shoulder girdle muscle weakness (HP:0003547)2.51492736
47Volvulus (HP:0002580)2.51061372
48Median cleft lip (HP:0000161)2.49948717
49Oligodactyly (HP:0012165)2.49526173
50Lipid accumulation in hepatocytes (HP:0006561)2.47862597
51Acute encephalopathy (HP:0006846)2.47075723
52Aplasia/hypoplasia of the uterus (HP:0008684)2.46326660
53Abnormality of lateral ventricle (HP:0030047)2.43024184
54Cortical dysplasia (HP:0002539)2.42939993
55Hypoplastic pelvis (HP:0008839)2.42054166
56Abnormality of the preputium (HP:0100587)2.41676130
57Deep venous thrombosis (HP:0002625)2.40751823
58Aplasia/Hypoplasia of the sacrum (HP:0008517)2.40216216
59Genetic anticipation (HP:0003743)2.39857381
60Cystic hygroma (HP:0000476)2.39779763
61Conjunctival telangiectasia (HP:0000524)2.37183816
62Short tibia (HP:0005736)2.36219848
63Mask-like facies (HP:0000298)2.33039172
64Obstructive sleep apnea (HP:0002870)2.32752108
65Azoospermia (HP:0000027)2.31584940
66Delayed puberty (HP:0000823)2.30927023
67Abnormality of chromosome segregation (HP:0002916)2.30546267
68Type 2 muscle fiber atrophy (HP:0003554)2.30011553
69Sloping forehead (HP:0000340)2.29117600
70Tubulointerstitial nephritis (HP:0001970)2.27674724
71Impulsivity (HP:0100710)2.26458780
72Acute myeloid leukemia (HP:0004808)2.26026256
73Nephroblastoma (Wilms tumor) (HP:0002667)2.24298242
74Abnormality of the corticospinal tract (HP:0002492)2.23992153
75Abnormality of male internal genitalia (HP:0000022)2.23352085
76Increased CSF lactate (HP:0002490)2.23201101
77Hip contracture (HP:0003273)2.22975569
78Nonprogressive disorder (HP:0003680)2.21439939
79Shallow orbits (HP:0000586)2.19433212
80Asymmetry of the thorax (HP:0001555)2.19385106
81Tetraplegia (HP:0002445)2.19219301
82Medial flaring of the eyebrow (HP:0010747)2.18285838
83High anterior hairline (HP:0009890)2.17828294
84Abnormal spermatogenesis (HP:0008669)2.16292985
85Abnormality of the phalanges of the hallux (HP:0010057)2.15051882
86Decreased muscle mass (HP:0003199)2.13743345
87Abnormality of the duodenum (HP:0002246)2.13380769
88Abnormality of liposaccharide metabolism (HP:0010968)2.13140369
89Abnormality of glycosphingolipid metabolism (HP:0004343)2.13140369
90Abnormality of glycolipid metabolism (HP:0010969)2.13140369
91Congenital primary aphakia (HP:0007707)2.12559591
92Atrophy/Degeneration involving motor neurons (HP:0007373)2.10926430
93Increased hepatocellular lipid droplets (HP:0006565)2.10726491
94Aplasia/Hypoplasia of the sternum (HP:0006714)2.10629450
95Hypoplasia of the uterus (HP:0000013)2.09176152
96Increased serum pyruvate (HP:0003542)2.07436743
97Abnormal hair whorl (HP:0010721)2.07217084
98Aplasia/Hypoplasia of the tibia (HP:0005772)2.07078684
99Confusion (HP:0001289)2.06532293
100Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.05019437
101Embryonal renal neoplasm (HP:0011794)2.05008314
102Mitochondrial inheritance (HP:0001427)2.03860543
103Absent radius (HP:0003974)2.01360704
104Sensorimotor neuropathy (HP:0007141)2.01148603
105Abnormal sex determination (HP:0012244)2.01118811
106Sex reversal (HP:0012245)2.01118811
107Gait imbalance (HP:0002141)2.01061958
108Atonic seizures (HP:0010819)2.00068942
109Supernumerary spleens (HP:0009799)1.98524778
110Morphological abnormality of the pyramidal tract (HP:0002062)1.96718532
111Ectopic kidney (HP:0000086)1.96613141
112Epidermoid cyst (HP:0200040)1.96423527
113Facial cleft (HP:0002006)1.96311821
114Heterotopia (HP:0002282)1.96243695
115Abnormality of serine family amino acid metabolism (HP:0010894)1.95670225
116Abnormality of glycine metabolism (HP:0010895)1.95670225
117Aplasia involving forearm bones (HP:0009822)1.94923046
118Absent forearm bone (HP:0003953)1.94923046
119Abnormality of the lower motor neuron (HP:0002366)1.94373545
120Neoplasm of the thyroid gland (HP:0100031)1.93310300
121Triphalangeal thumb (HP:0001199)1.92787113
122Dysmetric saccades (HP:0000641)1.92035314
123Preaxial hand polydactyly (HP:0001177)1.91732449
124Microglossia (HP:0000171)1.91478867
125Sandal gap (HP:0001852)1.91301256
126Medulloblastoma (HP:0002885)1.91078827
127Abnormality of the clitoris (HP:0000056)1.90341254
128Abnormality of the neuromuscular junction (HP:0003398)1.89385317
129Fatigable weakness (HP:0003473)1.89385317
130Myokymia (HP:0002411)1.88739030
131Increased serum lactate (HP:0002151)1.88385297
132Horseshoe kidney (HP:0000085)1.87968499
133Progressive macrocephaly (HP:0004481)1.87787156
134Focal motor seizures (HP:0011153)1.87298208
135Abnormality of glycolysis (HP:0004366)1.86777112
136Renal Fanconi syndrome (HP:0001994)1.86119394
137Astigmatism (HP:0000483)1.84906175
138Resting tremor (HP:0002322)1.84850410
139Hepatocellular necrosis (HP:0001404)1.83153242
140Muscle fiber atrophy (HP:0100295)1.81952029
141Increased intramyocellular lipid droplets (HP:0012240)1.81454019
142Hyperglycinuria (HP:0003108)1.80790529
143Hypoplastic ischia (HP:0003175)1.80169586
144Urinary bladder sphincter dysfunction (HP:0002839)1.79997095
145Termporal pattern (HP:0011008)1.79407599
146Insidious onset (HP:0003587)1.79407599
147Abnormality of the septum pellucidum (HP:0007375)1.79312558
148Dysautonomia (HP:0002459)1.79281905
149Peritonitis (HP:0002586)1.77925578
150Molar tooth sign on MRI (HP:0002419)1.77768762
151Abnormality of midbrain morphology (HP:0002418)1.77768762
152Abnormal number of incisors (HP:0011064)1.77606714
153Abnormality of serum amino acid levels (HP:0003112)1.76827910
154Hematochezia (HP:0002573)1.76447696
155Abnormality of the labia (HP:0000058)1.75870413
156Hepatic necrosis (HP:0002605)1.75516288
157Intrahepatic cholestasis (HP:0001406)1.74988624
158Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.74947744
159Degeneration of the lateral corticospinal tracts (HP:0002314)1.74947744
160Neck muscle weakness (HP:0000467)1.74743888
161Fibular aplasia (HP:0002990)1.74622533
162Embryonal neoplasm (HP:0002898)1.74142003
163Nephrogenic diabetes insipidus (HP:0009806)1.73844081
164Secondary amenorrhea (HP:0000869)1.73180450
165External ophthalmoplegia (HP:0000544)1.72693983
166Abnormality of the carotid arteries (HP:0005344)1.72369705
167Exercise intolerance (HP:0003546)1.71437586
168Progressive cerebellar ataxia (HP:0002073)1.71363134
169True hermaphroditism (HP:0010459)1.70785980
170Proximal placement of thumb (HP:0009623)1.70296191
171Reticulocytopenia (HP:0001896)1.68988993
172Fused cervical vertebrae (HP:0002949)1.68931880
173Increased muscle lipid content (HP:0009058)1.68415144
174Meckel diverticulum (HP:0002245)1.68266165
175Bifid tongue (HP:0010297)1.65992817
176Aplastic anemia (HP:0001915)1.65835949
177Retinal dysplasia (HP:0007973)1.65815053
178Long foot (HP:0001833)1.65547400
179Increased nuchal translucency (HP:0010880)1.65097600
180Poor coordination (HP:0002370)1.64682328
181Short thumb (HP:0009778)1.64651929
182Cerebellar dysplasia (HP:0007033)1.64066719
183Abnormal protein N-linked glycosylation (HP:0012347)1.63764769
184Abnormal protein glycosylation (HP:0012346)1.63764769
185Abnormal glycosylation (HP:0012345)1.63764769

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRSK27.09981033
2LATS23.95507606
3BRSK13.66531203
4STK38L3.50651270
5IRAK33.47830565
6SRPK13.43808967
7NEK63.20941530
8LATS13.20307070
9MARK33.10904578
10ZAK2.73401267
11PINK12.73289594
12ERBB42.73204480
13PLK32.58678071
14FRK2.46084050
15MUSK2.45558882
16CDC72.20687182
17TRIM282.09371761
18PBK2.06466051
19WEE12.05310014
20STK162.03483411
21MAP4K21.98740778
22MAP3K61.96448446
23TSSK61.84831437
24BMPR1B1.78419780
25PKN11.56593650
26PLK11.56179712
27STK241.54714400
28VRK21.53179145
29VRK11.48311129
30CHEK21.46182345
31ATR1.45568262
32WNK31.42898440
33BCKDK1.38114341
34STK41.36708429
35PLK21.33994654
36STK31.29961866
37BCR1.29632360
38PDK21.27477846
39TTK1.25193239
40PNCK1.23367123
41TNIK1.19233336
42NME11.13926248
43IRAK21.11196032
44FGFR21.10447114
45CCNB11.05062419
46MAP3K121.04907324
47FLT31.04659443
48CSNK1G31.03918881
49CDK81.03550645
50CDK191.02961463
51IRAK41.00588556
52MKNK10.98358230
53CSNK1A1L0.95588407
54MST40.94570777
55CSNK1G20.92636522
56CHEK10.91936868
57RIPK40.91535897
58DYRK20.88145642
59CDK120.88140880
60CDK30.87857064
61SGK20.86783174
62AURKB0.86619337
63CSNK1G10.86501678
64TAOK20.82154750
65PAK60.82029551
66NUAK10.80959191
67NEK20.79312859
68PRKAA10.77448675
69TAOK30.77314660
70FGFR30.76930645
71SGK4940.76285331
72SGK2230.76285331
73WNK40.76005214
74DMPK0.75273950
75STK380.74804313
76MAP3K50.73922454
77ERBB30.73448691
78RPS6KA50.73194057
79MAPK130.72072797
80MARK10.71535640
81PRKD30.70923721
82NEK10.69814530
83ATM0.69720743
84TESK20.67147975
85MAP3K40.66898867
86TAOK10.66232849
87CHUK0.63123887
88CDK140.62915829
89BRAF0.61238341
90ARAF0.60950395
91CDK20.60910735
92MET0.60684441
93ABL20.60288093
94EPHA40.59988283
95MAPK100.59941575
96CDK90.57494124
97DYRK30.57220730
98CDK10.57169358
99SGK30.55850917
100CSNK2A10.55539757
101MAP2K40.52993469
102MST1R0.52351095
103MAP3K80.49936422
104BRD40.49539576
105EIF2AK30.47391016
106UHMK10.47115900
107PIM20.47109285
108TGFBR10.46640666
109CSNK2A20.46623012
110PRKAA20.46063853
111BUB10.46027793
112TYRO30.45051678
113PIM10.44343219
114IKBKE0.42809751
115AURKA0.42698931
116TLK10.41852841
117MAPK150.40721187
118MKNK20.37712829
119PRKCG0.36940253
120AKT20.36697831
121DYRK1A0.35014085
122NEK90.34416001
123ALK0.34296527
124PRKACB0.34013289
125PASK0.33826181
126DDR20.33705729
127MAPK140.33280485
128CLK10.32177980
129MAPK80.32103877
130STK390.31944762
131LIMK10.30805035
132BMX0.30617762
133CDK70.30338341
134CSNK1E0.30177220
135IRAK10.30071456
136MAP2K70.29688740
137PRKCI0.29433631
138CDK150.27957507
139OXSR10.26751991
140EIF2AK20.26581974
141CDK11A0.26403382
142CDK180.25766381
143MAP3K90.25477683
144CAMK2A0.25250762
145GSK3B0.24068989
146TTN0.23246376
147NTRK30.21939040
148PLK40.21875446
149ABL10.21606922
150PRKCZ0.21576318
151EPHB20.21467199
152SGK10.20543027
153RAF10.19767287
154CAMK2B0.18979640
155MINK10.18720414

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.47370091
2RNA polymerase_Homo sapiens_hsa030204.10171417
3DNA replication_Homo sapiens_hsa030304.01279772
4Mismatch repair_Homo sapiens_hsa034303.83129490
5Basal transcription factors_Homo sapiens_hsa030223.73783229
6Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002503.28316757
7Base excision repair_Homo sapiens_hsa034102.98330965
8Cell cycle_Homo sapiens_hsa041102.84395265
9Proteasome_Homo sapiens_hsa030502.75099117
10Nucleotide excision repair_Homo sapiens_hsa034202.54112483
11Arginine biosynthesis_Homo sapiens_hsa002202.48286370
12Vitamin B6 metabolism_Homo sapiens_hsa007502.44324033
13Non-homologous end-joining_Homo sapiens_hsa034502.40670094
14Oocyte meiosis_Homo sapiens_hsa041142.30580067
15Protein export_Homo sapiens_hsa030602.28054963
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.13027811
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.02026051
18Primary bile acid biosynthesis_Homo sapiens_hsa001202.01314575
19Parkinsons disease_Homo sapiens_hsa050122.00738161
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.00473116
21Oxidative phosphorylation_Homo sapiens_hsa001901.88867799
22Selenocompound metabolism_Homo sapiens_hsa004501.83325684
23RNA degradation_Homo sapiens_hsa030181.72162394
24mRNA surveillance pathway_Homo sapiens_hsa030151.69616092
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.68426768
26Sulfur relay system_Homo sapiens_hsa041221.66714039
27Huntingtons disease_Homo sapiens_hsa050161.59002290
28Butanoate metabolism_Homo sapiens_hsa006501.57549594
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53500072
30MicroRNAs in cancer_Homo sapiens_hsa052061.52736575
31p53 signaling pathway_Homo sapiens_hsa041151.52123244
32RNA transport_Homo sapiens_hsa030131.51163963
33Ribosome_Homo sapiens_hsa030101.49680974
34Thyroid cancer_Homo sapiens_hsa052161.48121628
35Pentose phosphate pathway_Homo sapiens_hsa000301.47893552
36Pyruvate metabolism_Homo sapiens_hsa006201.46157593
37Folate biosynthesis_Homo sapiens_hsa007901.42250235
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.40296677
39One carbon pool by folate_Homo sapiens_hsa006701.38874077
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.36455349
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.34929254
42Amphetamine addiction_Homo sapiens_hsa050311.34244603
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33379677
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.31699149
45Biosynthesis of amino acids_Homo sapiens_hsa012301.30261641
46TGF-beta signaling pathway_Homo sapiens_hsa043501.27585745
47Fatty acid elongation_Homo sapiens_hsa000621.25397369
48Phototransduction_Homo sapiens_hsa047441.25282699
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.21464631
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20630222
51Carbon metabolism_Homo sapiens_hsa012001.16148844
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.13905010
53Cocaine addiction_Homo sapiens_hsa050301.13887488
54Steroid biosynthesis_Homo sapiens_hsa001001.12525924
55Glucagon signaling pathway_Homo sapiens_hsa049221.08371105
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07736405
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07606511
58Synaptic vesicle cycle_Homo sapiens_hsa047211.00071922
59Sphingolipid metabolism_Homo sapiens_hsa006000.94390926
60Alzheimers disease_Homo sapiens_hsa050100.94173881
61Complement and coagulation cascades_Homo sapiens_hsa046100.91876998
62Glutamatergic synapse_Homo sapiens_hsa047240.90386989
63Thyroid hormone synthesis_Homo sapiens_hsa049180.90064723
64Hedgehog signaling pathway_Homo sapiens_hsa043400.89247295
65Long-term potentiation_Homo sapiens_hsa047200.87322329
66Homologous recombination_Homo sapiens_hsa034400.85281873
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80618350
68Fanconi anemia pathway_Homo sapiens_hsa034600.80070548
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73692845
70Spliceosome_Homo sapiens_hsa030400.73393868
71Renal cell carcinoma_Homo sapiens_hsa052110.73229956
72Epstein-Barr virus infection_Homo sapiens_hsa051690.72991437
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71925808
74Collecting duct acid secretion_Homo sapiens_hsa049660.71178578
75Dorso-ventral axis formation_Homo sapiens_hsa043200.70849050
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69940498
77Fatty acid degradation_Homo sapiens_hsa000710.68222036
78GABAergic synapse_Homo sapiens_hsa047270.68064731
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66899785
80Estrogen signaling pathway_Homo sapiens_hsa049150.66149032
81GnRH signaling pathway_Homo sapiens_hsa049120.65646597
82Viral carcinogenesis_Homo sapiens_hsa052030.65517900
83Metabolic pathways_Homo sapiens_hsa011000.65076692
84Basal cell carcinoma_Homo sapiens_hsa052170.64412385
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.64193985
86Pyrimidine metabolism_Homo sapiens_hsa002400.63942917
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.63469222
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62889684
89Olfactory transduction_Homo sapiens_hsa047400.62350414
90Bile secretion_Homo sapiens_hsa049760.61900790
91Glutathione metabolism_Homo sapiens_hsa004800.60495568
92Tryptophan metabolism_Homo sapiens_hsa003800.60466332
93Cardiac muscle contraction_Homo sapiens_hsa042600.59231134
94Nicotine addiction_Homo sapiens_hsa050330.58973691
95Fructose and mannose metabolism_Homo sapiens_hsa000510.57983454
96Lysine degradation_Homo sapiens_hsa003100.57704983
97Platelet activation_Homo sapiens_hsa046110.57605206
98PPAR signaling pathway_Homo sapiens_hsa033200.54670883
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53348336
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53274612
101FoxO signaling pathway_Homo sapiens_hsa040680.52697333
102Oxytocin signaling pathway_Homo sapiens_hsa049210.52341077
103Purine metabolism_Homo sapiens_hsa002300.51744130
104Peroxisome_Homo sapiens_hsa041460.51273896
105Linoleic acid metabolism_Homo sapiens_hsa005910.50171308
106Axon guidance_Homo sapiens_hsa043600.49223020
107Insulin secretion_Homo sapiens_hsa049110.48138518
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48133593
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48026386
110Alcoholism_Homo sapiens_hsa050340.47880890
111Ovarian steroidogenesis_Homo sapiens_hsa049130.47742593
112Arginine and proline metabolism_Homo sapiens_hsa003300.46606975
113Cyanoamino acid metabolism_Homo sapiens_hsa004600.46500926
114Fatty acid metabolism_Homo sapiens_hsa012120.46484790
115cAMP signaling pathway_Homo sapiens_hsa040240.46280689
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46139606
117Circadian entrainment_Homo sapiens_hsa047130.45840072
118Hippo signaling pathway_Homo sapiens_hsa043900.45577901
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45283058
120Gap junction_Homo sapiens_hsa045400.44982117
121beta-Alanine metabolism_Homo sapiens_hsa004100.44611063
122Systemic lupus erythematosus_Homo sapiens_hsa053220.43774612
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43768050
124Salmonella infection_Homo sapiens_hsa051320.43143390
125Dopaminergic synapse_Homo sapiens_hsa047280.42507191
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42113568
127Ether lipid metabolism_Homo sapiens_hsa005650.41208210
128Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41174002
129Tyrosine metabolism_Homo sapiens_hsa003500.40982430
130Histidine metabolism_Homo sapiens_hsa003400.40839729
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40503897
132N-Glycan biosynthesis_Homo sapiens_hsa005100.39425874
133Wnt signaling pathway_Homo sapiens_hsa043100.39361831
134Staphylococcus aureus infection_Homo sapiens_hsa051500.38932913
135MAPK signaling pathway_Homo sapiens_hsa040100.38812465
136Influenza A_Homo sapiens_hsa051640.37819258
137Propanoate metabolism_Homo sapiens_hsa006400.37746592
138Shigellosis_Homo sapiens_hsa051310.37422564
139Endometrial cancer_Homo sapiens_hsa052130.35561539
140Pancreatic cancer_Homo sapiens_hsa052120.35244592
141Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34812010
142Choline metabolism in cancer_Homo sapiens_hsa052310.34487524
143Long-term depression_Homo sapiens_hsa047300.34404459
144cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32744432
145Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32326805
146Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32119808
147Drug metabolism - other enzymes_Homo sapiens_hsa009830.31692296
148Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30722694
149HTLV-I infection_Homo sapiens_hsa051660.30646688
150Maturity onset diabetes of the young_Homo sapiens_hsa049500.30494981
151Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28341828
152Regulation of autophagy_Homo sapiens_hsa041400.25534656
153Vibrio cholerae infection_Homo sapiens_hsa051100.22912233
154Circadian rhythm_Homo sapiens_hsa047100.20559859
155Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.19950223
156Taste transduction_Homo sapiens_hsa047420.19065341
157Phenylalanine metabolism_Homo sapiens_hsa003600.18890175
158Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.18524114
159Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13936044

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