KDM5C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.56718136
2nuclear pore complex assembly (GO:0051292)4.10440587
3COPI coating of Golgi vesicle (GO:0048205)3.95867295
4Golgi transport vesicle coating (GO:0048200)3.95867295
5nuclear pore organization (GO:0006999)3.95074148
6pre-miRNA processing (GO:0031054)3.90814518
7regulation of translational fidelity (GO:0006450)3.77167694
8regulation of NFAT protein import into nucleus (GO:0051532)3.65196647
9positive regulation of histone deacetylation (GO:0031065)3.65137314
10heterochromatin organization (GO:0070828)3.61120533
11regulation of histone H3-K27 methylation (GO:0061085)3.56169321
12regulation of nucleobase-containing compound transport (GO:0032239)3.50297322
13protein localization to endosome (GO:0036010)3.41197354
14negative regulation of histone methylation (GO:0031061)3.41164232
15mannose metabolic process (GO:0006013)3.34144423
16folic acid-containing compound biosynthetic process (GO:0009396)3.29510490
17cytoskeletal anchoring at plasma membrane (GO:0007016)3.28232368
18regulation of hippo signaling (GO:0035330)3.20199110
19glucocorticoid receptor signaling pathway (GO:0042921)3.16887031
20regulation of gene silencing by RNA (GO:0060966)3.14985145
21regulation of posttranscriptional gene silencing (GO:0060147)3.14985145
22regulation of gene silencing by miRNA (GO:0060964)3.14985145
23RNA stabilization (GO:0043489)3.11716978
24mRNA stabilization (GO:0048255)3.11716978
25chromatin assembly (GO:0031497)3.11258795
26positive regulation of SMAD protein import into nucleus (GO:0060391)3.10417042
27activation of Rac GTPase activity (GO:0032863)3.10075461
28retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.08149454
29dosage compensation (GO:0007549)3.06283452
30DNA unwinding involved in DNA replication (GO:0006268)3.04720781
31protein localization to kinetochore (GO:0034501)3.02388637
32NLS-bearing protein import into nucleus (GO:0006607)3.01605614
33response to laminar fluid shear stress (GO:0034616)2.97683148
34regulation of mammary gland epithelial cell proliferation (GO:0033599)2.97201754
35regulation of glucose import in response to insulin stimulus (GO:2001273)2.97092245
36positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.96626418
37pore complex assembly (GO:0046931)2.95488396
38regulation of early endosome to late endosome transport (GO:2000641)2.95452660
39maternal placenta development (GO:0001893)2.93554679
40cytoplasmic mRNA processing body assembly (GO:0033962)2.90698194
41corticosteroid receptor signaling pathway (GO:0031958)2.90537363
42paraxial mesoderm development (GO:0048339)2.89388491
43apoptotic process involved in morphogenesis (GO:0060561)2.88310976
44insulin-like growth factor receptor signaling pathway (GO:0048009)2.85593543
45trophectodermal cell differentiation (GO:0001829)2.85523160
46positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.83689930
47regulation of RNA export from nucleus (GO:0046831)2.83540227
48histone H3-K36 demethylation (GO:0070544)2.80280858
49peptidyl-lysine dimethylation (GO:0018027)2.79242967
50hippo signaling (GO:0035329)2.78872074
51response to UV-C (GO:0010225)2.78585812
52negative regulation of cell size (GO:0045792)2.78074335
53polarized epithelial cell differentiation (GO:0030859)2.76613008
54regulation of histone H3-K9 methylation (GO:0051570)2.75834099
55regulation of SMAD protein import into nucleus (GO:0060390)2.73998367
56embryonic process involved in female pregnancy (GO:0060136)2.72508837
57spliceosomal tri-snRNP complex assembly (GO:0000244)2.72228512
58regulation of cholesterol homeostasis (GO:2000188)2.70990451
59mitotic nuclear envelope disassembly (GO:0007077)2.70628960
60embryonic placenta development (GO:0001892)2.68034507
61establishment of apical/basal cell polarity (GO:0035089)2.67878421
62semaphorin-plexin signaling pathway (GO:0071526)2.66185074
63negative regulation of myotube differentiation (GO:0010832)2.66173851
64epithelial cell differentiation involved in prostate gland development (GO:0060742)2.65162114
65intracellular estrogen receptor signaling pathway (GO:0030520)2.64924127
66regulation of mitotic spindle organization (GO:0060236)2.63532987
67response to epidermal growth factor (GO:0070849)2.62625657
68DNA duplex unwinding (GO:0032508)2.62479625
69regulation of chromatin binding (GO:0035561)2.62452165
70regulation of fatty acid beta-oxidation (GO:0031998)2.60617970
71histone H3-K9 demethylation (GO:0033169)2.59147106
72DNA geometric change (GO:0032392)2.59122920
73response to muramyl dipeptide (GO:0032495)2.59111188
74membrane disassembly (GO:0030397)2.59093335
75nuclear envelope disassembly (GO:0051081)2.59093335
76adherens junction assembly (GO:0034333)2.59069908
77sister chromatid segregation (GO:0000819)2.58277384
78positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.57006856
79regulation of translational termination (GO:0006449)2.55588066
80histone H2A monoubiquitination (GO:0035518)2.54388412
81epithelial cell-cell adhesion (GO:0090136)2.52932245
82positive regulation of blood vessel endothelial cell migration (GO:0043536)2.52684844
83growth hormone receptor signaling pathway (GO:0060396)2.52105929
84positive regulation of protein deacetylation (GO:0090312)2.51180692
85negative regulation of fatty acid transport (GO:2000192)2.50615165
86positive regulation of p38MAPK cascade (GO:1900745)2.50562811
87positive regulation of mitotic sister chromatid separation (GO:1901970)2.49024724
88positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.49024724
89positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.49024724
90stress fiber assembly (GO:0043149)2.48636792
91basement membrane organization (GO:0071711)2.48502770
92planar cell polarity pathway involved in neural tube closure (GO:0090179)2.48385618
93hemidesmosome assembly (GO:0031581)2.48295423
94embryonic eye morphogenesis (GO:0048048)2.47957662
95regulation of sister chromatid cohesion (GO:0007063)2.47492931
96regulation of ARF protein signal transduction (GO:0032012)2.47467510
97protein export from nucleus (GO:0006611)2.47407139
98L-alpha-amino acid transmembrane transport (GO:1902475)2.46927964
99proline biosynthetic process (GO:0006561)2.46153724
100mitotic sister chromatid cohesion (GO:0007064)2.45325856
101positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.43596060
102cell-substrate junction assembly (GO:0007044)2.42492842
103cellular protein complex localization (GO:0034629)2.41888322
104negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.41176406
105regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.41165111
106modulation by symbiont of host cellular process (GO:0044068)2.40890070
107positive regulation of fatty acid beta-oxidation (GO:0032000)2.40599044
108stress granule assembly (GO:0034063)2.39814422
109desmosome organization (GO:0002934)2.39474540
110maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.39363929
111negative regulation of viral release from host cell (GO:1902187)2.38995482
112activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.38665485
113protein retention in ER lumen (GO:0006621)2.38100846
114cellular response to epidermal growth factor stimulus (GO:0071364)2.37397395
115regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.37086075
116mitotic chromosome condensation (GO:0007076)2.35554233
117skin morphogenesis (GO:0043589)2.34261717
118apoptotic cell clearance (GO:0043277)2.34074008
119positive regulation of nuclease activity (GO:0032075)2.33392182
120thymic T cell selection (GO:0045061)2.32961727
121activation of JUN kinase activity (GO:0007257)2.32853812
122low-density lipoprotein particle clearance (GO:0034383)2.32794756
123activation of MAPKKK activity (GO:0000185)2.32583566
124regulation of gamma-delta T cell differentiation (GO:0045586)2.32152389
125gastrulation with mouth forming second (GO:0001702)2.31381858
126cell-substrate adherens junction assembly (GO:0007045)2.29797330
127focal adhesion assembly (GO:0048041)2.29797330
128embryonic camera-type eye morphogenesis (GO:0048596)2.29401359
129protein-DNA complex disassembly (GO:0032986)2.29299655
130nucleosome disassembly (GO:0006337)2.29299655
131positive regulation of Cdc42 GTPase activity (GO:0043089)2.28695464
132regulation of gene silencing (GO:0060968)2.28127314
133positive regulation of gene expression, epigenetic (GO:0045815)2.27864751
134histone H4 deacetylation (GO:0070933)2.27717672
135positive regulation of chromosome segregation (GO:0051984)2.27350223
136embryonic retina morphogenesis in camera-type eye (GO:0060059)2.27286370
137regulation of type I interferon-mediated signaling pathway (GO:0060338)2.26238375
138regulation of integrin activation (GO:0033623)2.25958456
139protein localization to chromosome, centromeric region (GO:0071459)2.25746932
140regulation of ARF GTPase activity (GO:0032312)2.25229208
141antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.25053459
142antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.25053459
143positive regulation of RNA splicing (GO:0033120)2.24860469
144atrioventricular valve morphogenesis (GO:0003181)2.23466861
145cortical actin cytoskeleton organization (GO:0030866)2.22495561
146negative regulation of histone modification (GO:0031057)2.21754087
147negative regulation of striated muscle cell differentiation (GO:0051154)2.21664705
148regulation of mRNA stability (GO:0043488)2.21111811
149regulation of protein polyubiquitination (GO:1902914)2.20998283
150embryonic foregut morphogenesis (GO:0048617)2.20680564
151IMP biosynthetic process (GO:0006188)2.20479646
1523-UTR-mediated mRNA stabilization (GO:0070935)2.20370340
153tetrahydrofolate metabolic process (GO:0046653)2.20280696
154regulation of spindle organization (GO:0090224)2.20105860
155branching involved in mammary gland duct morphogenesis (GO:0060444)2.19865523
156regulation of nuclease activity (GO:0032069)2.18395691
157endoplasmic reticulum unfolded protein response (GO:0030968)2.18192551
158peptidyl-threonine modification (GO:0018210)2.18066015
159positive regulation of myotube differentiation (GO:0010831)2.17961997
160peptidyl-threonine phosphorylation (GO:0018107)2.15689645
161modulation by virus of host process (GO:0019054)2.15595265
162positive regulation of gamma-delta T cell activation (GO:0046645)2.15456693
163vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.14797732

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.47664918
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.82654366
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.80895381
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.77489887
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.34065042
6MYC_22102868_ChIP-Seq_BL_Human3.32293209
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.38145321
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.19121993
9TCF7_22412390_ChIP-Seq_EML_Mouse2.04177640
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.02196011
11VDR_21846776_ChIP-Seq_THP-1_Human2.01744866
12CLOCK_20551151_ChIP-Seq_293T_Human1.96750247
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.93046677
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.91911600
15KDM2B_26808549_Chip-Seq_DND41_Human1.90116451
16KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.88093555
17ZNF263_19887448_ChIP-Seq_K562_Human1.85120153
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.82301470
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79122514
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.77744278
21ELK3_25401928_ChIP-Seq_HUVEC_Human1.76997330
22KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.74366711
23KDM2B_26808549_Chip-Seq_SUP-B15_Human1.72577912
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.71593305
25PPARA_22158963_ChIP-Seq_LIVER_Mouse1.71578760
26HIF1A_21447827_ChIP-Seq_MCF-7_Human1.68864098
27SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.64792168
28ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.64293303
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.62743670
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61384278
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.58664450
32RXR_22158963_ChIP-Seq_LIVER_Mouse1.49249804
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.47996531
34* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.47490614
35STAT3_1855785_ChIP-Seq_MESCs_Mouse1.45714770
36* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.44096515
37P300_27058665_Chip-Seq_ZR-75-30cells_Human1.43523984
38UTX_26944678_Chip-Seq_JUKART_Human1.43299462
39MAF_26560356_Chip-Seq_TH1_Human1.42082029
40CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.41245120
41NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.41058413
42EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40342497
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.39774657
44NCOR1_26117541_ChIP-Seq_K562_Human1.39254541
45ATF3_27146783_Chip-Seq_COLON_Human1.38557137
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38290652
47RACK7_27058665_Chip-Seq_MCF-7_Human1.36049263
48ESR1_15608294_ChIP-ChIP_MCF-7_Human1.35736497
49UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.34854458
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34186139
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34140225
52CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34136014
53KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.32236548
54KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.32236548
55KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.32236548
56MAF_26560356_Chip-Seq_TH2_Human1.31381774
57TCF3_18692474_ChIP-Seq_MEFs_Mouse1.31219057
58SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.30744641
59KDM2B_26808549_Chip-Seq_JURKAT_Human1.30654236
60RUNX1_22412390_ChIP-Seq_EML_Mouse1.30393931
61PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28422427
62RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27510996
63LXR_22158963_ChIP-Seq_LIVER_Mouse1.26589498
64TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26503680
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.26132989
66RUNX1_27514584_Chip-Seq_MCF-7_Human1.25443499
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24398257
68BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24348719
69ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21668947
70NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21091163
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.20544351
72CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20352656
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20176111
74GATA6_25053715_ChIP-Seq_YYC3_Human1.19542010
75* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19448311
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19352260
77SA1_27219007_Chip-Seq_ERYTHROID_Human1.19207857
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18055010
79FOXO3_23340844_ChIP-Seq_DLD1_Human1.17594431
80MYC_19079543_ChIP-ChIP_MESCs_Mouse1.16477425
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16470414
82P68_20966046_ChIP-Seq_HELA_Human1.16392498
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15998731
84SMC4_20622854_ChIP-Seq_HELA_Human1.15500129
85CHD1_26751641_Chip-Seq_LNCaP_Human1.14937993
86NANOG_21062744_ChIP-ChIP_HESCs_Human1.14859946
87SALL1_21062744_ChIP-ChIP_HESCs_Human1.14452403
88* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.13692848
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13428349
90AR_21909140_ChIP-Seq_LNCAP_Human1.12321775
91HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.12215852
92MYB_21317192_ChIP-Seq_ERMYB_Mouse1.12105582
93MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.11893896
94LXR_22292898_ChIP-Seq_THP-1_Human1.10547655
95NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10061528
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09986572
97TCF3_18692474_ChIP-Seq_MESCs_Mouse1.09837087
98NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.09657242
99GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08929703
100CIITA_25753668_ChIP-Seq_RAJI_Human1.08641636
101TP53_22127205_ChIP-Seq_IMR90_Human1.07016133
102SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06908836
103KDM2B_26808549_Chip-Seq_K562_Human1.06339211
104FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.05464826
105TET1_21451524_ChIP-Seq_MESCs_Mouse1.04518959
106GATA1_19941827_ChIP-Seq_MEL_Mouse1.03877351
107NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03782384
108E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03343978
109TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03262479
110EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03145167
111MYB_26560356_Chip-Seq_TH1_Human1.03098352
112CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02895569
113CREB1_26743006_Chip-Seq_LNCaP_Human1.02790264
114NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.02779448
115SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02620243
116GATA1_19941826_ChIP-Seq_K562_Human1.02376242
117DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02176459
118FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.02154859
119EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02036251
120ERG_21242973_ChIP-ChIP_JURKAT_Human1.01526814
121MYC_18555785_ChIP-Seq_MESCs_Mouse1.01336577
122SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.01276953
123TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00464524
124VDR_24763502_ChIP-Seq_THP-1_Human0.99182435
125TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98492019
126FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.98165217
127RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98122339
128PKCTHETA_26484144_Chip-Seq_BREAST_Human0.98057907
129ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97942454
130WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97389893
131HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97276576
132UBF1/2_26484160_Chip-Seq_HMECs_Human0.97245141
133ESR2_21235772_ChIP-Seq_MCF-7_Human0.96828386
134GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95579435
135SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94255191
136SCL_19346495_ChIP-Seq_HPC-7_Human0.93205423
137SPI1_23127762_ChIP-Seq_K562_Human0.92040195
138* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.90621016
139PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89845127

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.29738918
2MP0010352_gastrointestinal_tract_polyps3.33912371
3MP0005076_abnormal_cell_differentiation3.06968322
4MP0010234_abnormal_vibrissa_follicle2.87110836
5MP0005451_abnormal_body_composition2.72855772
6MP0002877_abnormal_melanocyte_morpholog2.24674750
7MP0003566_abnormal_cell_adhesion2.21668009
8MP0003300_gastrointestinal_ulcer2.21014241
9MP0005409_darkened_coat_color2.20158645
10MP0010307_abnormal_tumor_latency1.99359592
11MP0008260_abnormal_autophagy1.94318974
12MP0005058_abnormal_lysosome_morphology1.87720924
13MP0008438_abnormal_cutaneous_collagen1.86454593
14MP0009053_abnormal_anal_canal1.80133692
15MP0001849_ear_inflammation1.75326738
16MP0004858_abnormal_nervous_system1.74115584
17MP0002009_preneoplasia1.72650261
18MP0004197_abnormal_fetal_growth/weight/1.71771882
19MP0009278_abnormal_bone_marrow1.70134204
20MP0004233_abnormal_muscle_weight1.63858433
21MP0003763_abnormal_thymus_physiology1.56467473
22MP0004185_abnormal_adipocyte_glucose1.53850224
23MP0003436_decreased_susceptibility_to1.53784193
24MP0002086_abnormal_extraembryonic_tissu1.49793437
25MP0002088_abnormal_embryonic_growth/wei1.49284154
26MP0005023_abnormal_wound_healing1.49135258
27MP0003984_embryonic_growth_retardation1.48495630
28MP0001730_embryonic_growth_arrest1.48476960
29MP0005380_embryogenesis_phenotype1.47712564
30MP0001672_abnormal_embryogenesis/_devel1.47712564
31MP0000350_abnormal_cell_proliferation1.47223913
32MP0003111_abnormal_nucleus_morphology1.46981087
33MP0000678_abnormal_parathyroid_gland1.44345950
34MP0003252_abnormal_bile_duct1.44328636
35MP0010030_abnormal_orbit_morphology1.40535399
36MP0003172_abnormal_lysosome_physiology1.40113466
37MP0001348_abnormal_lacrimal_gland1.38433356
38MP0003303_peritoneal_inflammation1.37909541
39MP0000733_abnormal_muscle_development1.37515596
40* MP0002084_abnormal_developmental_patter1.35690385
41MP0000858_altered_metastatic_potential1.32268825
42MP0004264_abnormal_extraembryonic_tissu1.31879406
43MP0001915_intracranial_hemorrhage1.31364489
44MP0003453_abnormal_keratinocyte_physiol1.30565232
45MP0006054_spinal_hemorrhage1.29552967
46MP0002249_abnormal_larynx_morphology1.28736506
47MP0003077_abnormal_cell_cycle1.28570529
48MP0005275_abnormal_skin_tensile1.28230002
49MP0003091_abnormal_cell_migration1.21756988
50MP0004808_abnormal_hematopoietic_stem1.21528012
51MP0002085_abnormal_embryonic_tissue1.20779080
52MP0001697_abnormal_embryo_size1.20489422
53MP0002139_abnormal_hepatobiliary_system1.18912700
54MP0000537_abnormal_urethra_morphology1.17494249
55MP0003191_abnormal_cellular_cholesterol1.17471494
56MP0005621_abnormal_cell_physiology1.16485152
57MP0002166_altered_tumor_susceptibility1.15881832
58MP0004957_abnormal_blastocyst_morpholog1.14872323
59MP0002254_reproductive_system_inflammat1.13954149
60MP0002697_abnormal_eye_size1.12618848
61MP0000569_abnormal_digit_pigmentation1.12417969
62MP0002060_abnormal_skin_morphology1.12103290
63MP0004381_abnormal_hair_follicle1.11053205
64MP0003115_abnormal_respiratory_system1.09343357
65MP0002925_abnormal_cardiovascular_devel1.08332817
66MP0002080_prenatal_lethality1.08134837
67MP0008961_abnormal_basal_metabolism1.07403767
68MP0005666_abnormal_adipose_tissue1.06107966
69MP0004947_skin_inflammation1.03888384
70MP0002089_abnormal_postnatal_growth/wei1.03778738
71MP0010094_abnormal_chromosome_stability1.03701978
72MP0002092_abnormal_eye_morphology1.03573439
73MP0005257_abnormal_intraocular_pressure1.03425736
74MP0003890_abnormal_embryonic-extraembry1.02383516
75MP0010630_abnormal_cardiac_muscle1.01820083
76MP0003119_abnormal_digestive_system1.01215591
77MP0003283_abnormal_digestive_organ1.01098457
78MP0008007_abnormal_cellular_replicative1.00944591
79MP0002396_abnormal_hematopoietic_system0.99378715
80MP0001873_stomach_inflammation0.99184428
81MP0005360_urolithiasis0.99001973
82MP0009333_abnormal_splenocyte_physiolog0.98987175
83MP0009703_decreased_birth_body0.96911231
84MP0002796_impaired_skin_barrier0.96524468
85MP0003567_abnormal_fetal_cardiomyocyte0.96446996
86MP0000703_abnormal_thymus_morphology0.95799968
87MP0005501_abnormal_skin_physiology0.95726238
88MP0005623_abnormal_meninges_morphology0.94779501
89MP0003279_aneurysm0.94201449
90MP0000516_abnormal_urinary_system0.94160202
91MP0005367_renal/urinary_system_phenotyp0.94160202
92MP0000428_abnormal_craniofacial_morphol0.93799282
93MP0000579_abnormal_nail_morphology0.93268849
94MP0009931_abnormal_skin_appearance0.92726787
95MP0001958_emphysema0.92679154
96MP0003329_amyloid_beta_deposits0.91173385
97MP0003828_pulmonary_edema0.91107697
98MP0009672_abnormal_birth_weight0.91048621
99MP0000609_abnormal_liver_physiology0.91009212
100MP0000759_abnormal_skeletal_muscle0.90657239
101MP0005375_adipose_tissue_phenotype0.90626844
102MP0002098_abnormal_vibrissa_morphology0.89985103
103MP0005248_abnormal_Harderian_gland0.88798472
104MP0004087_abnormal_muscle_fiber0.88692733
105MP0003045_fibrosis0.87894725
106MP0002998_abnormal_bone_remodeling0.87857280
107MP0010678_abnormal_skin_adnexa0.87821913
108MP0003221_abnormal_cardiomyocyte_apopto0.87784223
109MP0004272_abnormal_basement_membrane0.87157135
110MP0005397_hematopoietic_system_phenotyp0.85368889
111MP0001545_abnormal_hematopoietic_system0.85368889
112MP0000490_abnormal_crypts_of0.85052334
113MP0009840_abnormal_foam_cell0.83097734
114MP0005365_abnormal_bile_salt0.82962934
115MP0003935_abnormal_craniofacial_develop0.81317290
116MP0000767_abnormal_smooth_muscle0.80597062
117MP0004510_myositis0.79694471
118MP0003448_altered_tumor_morphology0.79617222
119MP0000598_abnormal_liver_morphology0.79025057
120MP0003693_abnormal_embryo_hatching0.78907091
121* MP0000266_abnormal_heart_morphology0.78474520
122MP0002111_abnormal_tail_morphology0.78208593
123MP0002398_abnormal_bone_marrow0.77554369
124MP0002896_abnormal_bone_mineralization0.77212697
125MP0000751_myopathy0.76820270
126MP0000685_abnormal_immune_system0.76609563
127MP0001851_eye_inflammation0.76598284
128MP0008057_abnormal_DNA_replication0.76185065
129MP0002019_abnormal_tumor_incidence0.75960218
130MP0002006_tumorigenesis0.75819126
131MP0000747_muscle_weakness0.75167552
132MP0000003_abnormal_adipose_tissue0.74962999
133MP0001243_abnormal_dermal_layer0.74861776
134MP0001293_anophthalmia0.74554561
135MP0001216_abnormal_epidermal_layer0.74438176
136MP0000477_abnormal_intestine_morphology0.74434913
137MP0000377_abnormal_hair_follicle0.74302691
138MP0008770_decreased_survivor_rate0.73896142
139MP0000467_abnormal_esophagus_morphology0.73448650
140MP0005384_cellular_phenotype0.73392416
141MP0006138_congestive_heart_failure0.73057136
142MP0004782_abnormal_surfactant_physiolog0.72569278

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)3.36331890
2Broad face (HP:0000283)3.16303025
3Hyperacusis (HP:0010780)2.81911105
4Protrusio acetabuli (HP:0003179)2.78923473
5Obstructive sleep apnea (HP:0002870)2.77497244
6Short 4th metacarpal (HP:0010044)2.71309950
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.71309950
8Ependymoma (HP:0002888)2.65207046
9Shallow orbits (HP:0000586)2.60520395
10Pseudobulbar signs (HP:0002200)2.54756320
11Abnormality of the fingertips (HP:0001211)2.53549824
12Macroorchidism (HP:0000053)2.50839012
13Ulnar bowing (HP:0003031)2.49869084
14Disproportionate tall stature (HP:0001519)2.48255458
15Flat acetabular roof (HP:0003180)2.43991111
16Dysmetric saccades (HP:0000641)2.42058608
17Mitral valve prolapse (HP:0001634)2.40745274
18Aneurysm (HP:0002617)2.39942967
19Abnormality of the astrocytes (HP:0100707)2.39060996
20Astrocytoma (HP:0009592)2.39060996
21Ankle contracture (HP:0006466)2.37457967
22Ankyloglossia (HP:0010296)2.35961134
23Abnormality of the distal phalanx of the thumb (HP:0009617)2.34234105
24Abnormality of the 4th metacarpal (HP:0010012)2.30876195
25Spastic diplegia (HP:0001264)2.24189315
26Heterotopia (HP:0002282)2.23883180
27Subacute progressive viral hepatitis (HP:0006572)2.21980414
28Long palpebral fissure (HP:0000637)2.21062768
29Increased connective tissue (HP:0009025)2.20600268
30Lymphangioma (HP:0100764)2.15261833
31Abnormality of oral frenula (HP:0000190)2.15015649
32Insomnia (HP:0100785)2.14412295
33Syringomyelia (HP:0003396)2.13659972
34Spinal cord lesions (HP:0100561)2.13659972
35Deviation of the thumb (HP:0009603)2.13257283
36Centrally nucleated skeletal muscle fibers (HP:0003687)2.12977803
37Aortic aneurysm (HP:0004942)2.08944997
38Genu recurvatum (HP:0002816)2.03868958
39Achilles tendon contracture (HP:0001771)2.01376257
40Malignant gastrointestinal tract tumors (HP:0006749)2.01021727
41Gastrointestinal carcinoma (HP:0002672)2.01021727
42Renovascular hypertension (HP:0100817)2.00984166
43Renal duplication (HP:0000075)2.00689577
44Long eyelashes (HP:0000527)1.98499750
45Cellulitis (HP:0100658)1.97616165
46Dislocated radial head (HP:0003083)1.97482194
47Bowel diverticulosis (HP:0005222)1.96127108
48Dilatation of the ascending aorta (HP:0005111)1.94588954
49Increased variability in muscle fiber diameter (HP:0003557)1.93054651
50Advanced eruption of teeth (HP:0006288)1.93052635
51Pointed chin (HP:0000307)1.92583807
52Hand muscle atrophy (HP:0009130)1.92532002
53Proximal placement of thumb (HP:0009623)1.92442511
54Vertebral compression fractures (HP:0002953)1.91724023
55Increased IgE level (HP:0003212)1.91448760
56Deep venous thrombosis (HP:0002625)1.91296360
57Segmental peripheral demyelination/remyelination (HP:0003481)1.90663023
58Colitis (HP:0002583)1.89803329
59Hematochezia (HP:0002573)1.88897721
60Upper limb amyotrophy (HP:0009129)1.88769823
61Distal upper limb amyotrophy (HP:0007149)1.88769823
62Hypochromic microcytic anemia (HP:0004840)1.88723601
63Cortical dysplasia (HP:0002539)1.88705826
64Premature rupture of membranes (HP:0001788)1.88533636
65Sparse lateral eyebrow (HP:0005338)1.87317089
66Eczematoid dermatitis (HP:0000976)1.86415485
67Mitral regurgitation (HP:0001653)1.85836740
68Enlarged penis (HP:0000040)1.85533832
69Abnormality of the calcaneus (HP:0008364)1.84240960
70Germ cell neoplasia (HP:0100728)1.83835741
71Increased density of long bones (HP:0006392)1.83572111
72Fragile skin (HP:0001030)1.83313636
73Myocardial infarction (HP:0001658)1.82977802
74Patellar dislocation (HP:0002999)1.82695930
75Abnormality of the radial head (HP:0003995)1.81553117
76Rectal prolapse (HP:0002035)1.80789772
77Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.80508159
78Elfin facies (HP:0004428)1.80408731
79Increased nuchal translucency (HP:0010880)1.79576216
80Biconcave vertebral bodies (HP:0004586)1.78227234
81Skin tags (HP:0010609)1.77918553
82Peritonitis (HP:0002586)1.77878763
83Bladder diverticulum (HP:0000015)1.76984573
84Abnormality of the thoracic spine (HP:0100711)1.76251389
85Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.76156594
86Selective tooth agenesis (HP:0001592)1.75413708
87Deep palmar crease (HP:0006191)1.74711701
88Esophageal varix (HP:0002040)1.74490327
89Increased mean platelet volume (HP:0011877)1.74248587
90Abnormality of the Achilles tendon (HP:0005109)1.74011538
91Broad thumb (HP:0011304)1.73373626
92Fibroma (HP:0010614)1.72291907
93Thin bony cortex (HP:0002753)1.71829074
94Abnormality of skeletal muscle fiber size (HP:0012084)1.71120643
95Persistence of primary teeth (HP:0006335)1.71062778
96Right ventricular cardiomyopathy (HP:0011663)1.71027596
97Fibrous tissue neoplasm (HP:0012316)1.70837800
98Vertebral arch anomaly (HP:0008438)1.69580635
99Vertebral clefting (HP:0008428)1.68829255
100Neonatal hypoglycemia (HP:0001998)1.68372468
101Back pain (HP:0003418)1.68360569
102Urethral obstruction (HP:0000796)1.68103618
103Abnormality of nail color (HP:0100643)1.68023482
104Wormian bones (HP:0002645)1.67942574
105Arnold-Chiari malformation (HP:0002308)1.67623898
106Glioma (HP:0009733)1.67394968
107Deviation of the hallux (HP:0010051)1.67184681
108Missing ribs (HP:0000921)1.66646691
109Hallux valgus (HP:0001822)1.66337998
110Reticulocytosis (HP:0001923)1.66240707
111Thin ribs (HP:0000883)1.66028104
112Osteolytic defects of the phalanges of the hand (HP:0009771)1.65871087
113Osteolytic defects of the hand bones (HP:0009699)1.65871087
114High pitched voice (HP:0001620)1.65488876
115Abnormality of the lower motor neuron (HP:0002366)1.64864582
116Natal tooth (HP:0000695)1.64436861
117Abnormality of the distal phalanges of the toes (HP:0010182)1.63941373
118Spinal rigidity (HP:0003306)1.63880867
119Mildly elevated creatine phosphokinase (HP:0008180)1.62984965
120Interstitial pulmonary disease (HP:0006530)1.62541655
121Metaphyseal cupping (HP:0003021)1.62497787
122Arterial tortuosity (HP:0005116)1.61987941
123Asymmetry of the thorax (HP:0001555)1.61292470
124Bowel incontinence (HP:0002607)1.61109389
125Abnormal platelet volume (HP:0011876)1.60238908
126Abnormality of monocarboxylic acid metabolism (HP:0010996)1.59486562
127Volvulus (HP:0002580)1.59431084
128Abnormality of the peritoneum (HP:0002585)1.59411654
129Cerebral inclusion bodies (HP:0100314)1.59182071
130Joint laxity (HP:0001388)1.59175564
131Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.59075004
132Turricephaly (HP:0000262)1.58910623
133Hemorrhage of the eye (HP:0011885)1.58771240
134Tibial bowing (HP:0002982)1.58718526
135Large earlobe (HP:0009748)1.58393059
136Distal lower limb muscle weakness (HP:0009053)1.57826098
137Transitional cell carcinoma of the bladder (HP:0006740)1.57701402
138Blue sclerae (HP:0000592)1.57501931
139Uterine leiomyosarcoma (HP:0002891)1.57431765
140Leiomyosarcoma (HP:0100243)1.57431765
141Biliary tract neoplasm (HP:0100574)1.57012318
142Short nail (HP:0001799)1.56883749
143Radial bowing (HP:0002986)1.56623616
144Skull defect (HP:0001362)1.56439775
145Onion bulb formation (HP:0003383)1.56374231
146Premature skin wrinkling (HP:0100678)1.56184607
147Atrophic scars (HP:0001075)1.55685282
148Short 1st metacarpal (HP:0010034)1.55212140
149Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.55212140
150Relative macrocephaly (HP:0004482)1.55011438
151Aortic dissection (HP:0002647)1.54235698
152Deep philtrum (HP:0002002)1.54090608
153Cutaneous melanoma (HP:0012056)1.53487274
154Bowing of the arm (HP:0006488)1.53065600
155Bowed forearm bones (HP:0003956)1.53065600
156Camptodactyly of toe (HP:0001836)1.53033798
157Difficulty climbing stairs (HP:0003551)1.52957291
158Cervical subluxation (HP:0003308)1.52929080
159Abnormality of the phalanges of the hallux (HP:0010057)1.52770962
160Sandal gap (HP:0001852)1.52769442
161Precocious puberty (HP:0000826)1.52450533
162Short humerus (HP:0005792)1.52400617
163Neoplasm of the oral cavity (HP:0100649)1.51633681
164Overriding aorta (HP:0002623)1.49736727
165Bronchomalacia (HP:0002780)1.49009194
166Abnormal large intestine physiology (HP:0012700)1.48834750

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.93730355
2MAP3K103.80572238
3TRIB33.77866683
4EEF2K3.70354504
5PKN23.56470336
6PRPF4B3.56086980
7SMG13.45042084
8SIK12.47760383
9LATS12.14768963
10ERN12.13709713
11PTK62.08218637
12RIPK11.96313408
13IRAK31.94178663
14TTN1.93043836
15BRD41.87326787
16PDGFRA1.85994565
17STK101.61430732
18MAP3K131.57598989
19FGFR41.57440254
20ICK1.52846716
21MTOR1.51033568
22RPS6KB21.47374697
23CDK61.45063008
24FLT31.43827608
25FGFR31.43247244
26EPHA21.42264615
27KSR21.40758219
28BMX1.33753375
29ALK1.32923427
30CAMK1D1.29480755
31NEK21.27901968
32MARK21.23714989
33CDK41.20323880
34CDC71.20042718
35LRRK21.15504795
36MAP4K11.13607539
37SCYL21.09035544
38PAK41.08923587
39RIPK41.05826392
40CHUK1.02676207
41STK30.99241472
42STK40.97872562
43MST1R0.97169852
44TAOK20.96879894
45DDR20.96554068
46JAK30.94720542
47PIM10.94712359
48PDGFRB0.91909727
49MAP3K80.91491880
50GRK60.90529084
51FGFR10.87692296
52MAP3K60.87226518
53MAP3K10.85584993
54PTK20.84787541
55PAK20.84551655
56JAK10.84403555
57EPHA30.84327168
58TYK20.84081136
59PASK0.83205083
60NEK10.80575325
61RPS6KA20.80334009
62PRKD20.79848724
63EPHB10.79278603
64DYRK1B0.77858047
65FGFR20.77006722
66CAMK1G0.76194127
67TGFBR20.75398491
68TTK0.75291243
69SIK20.74806180
70FRK0.74239048
71CDK90.72606226
72IRAK40.71840595
73PDPK10.69891130
74CSF1R0.69028530
75RPS6KL10.68379589
76RPS6KC10.68379589
77CDK70.67997818
78CHEK10.66701630
79NTRK10.66533297
80TYRO30.65858113
81MAP3K70.65834016
82RPS6KA40.63593713
83AKT20.61930042
84SIK30.60093027
85IRAK20.59828576
86NME20.59822494
87MAP3K20.57989754
88JAK20.57856142
89ATR0.57531267
90HIPK20.56764715
91MAPK110.56166307
92MAP3K30.55279505
93PRKD30.54641639
94LATS20.54387136
95MELK0.54336372
96CSK0.54098716
97TGFBR10.53514458
98* CDK20.53153726
99MAP2K30.52479928
100AURKB0.52239745
101RET0.51603832
102WNK10.51372356
103LMTK20.51311509
104EPHB20.51001944
105ATM0.49003572
106ERBB20.47764675
107CAMKK10.47137707
108RPS6KA10.46696724
109GSK3A0.46078593
110RPS6KA60.45550716
111MET0.44956899
112BTK0.44813136
113BLK0.44360506
114PDK10.44237131
115MAP2K20.44087170
116CSNK1D0.43916013
117SGK30.43269121
118TAOK10.43246342
119MAP3K140.42982689
120BRAF0.42790737
121AKT10.42262650
122MAPK10.41622213
123NEK90.40814142
124CDC42BPA0.40454075
125ZAP700.40262184
126MAP3K90.40251781
127ITK0.40198436
128PRKAA10.39045653
129IKBKB0.38838365
130KSR10.38820436
131HCK0.38767821
132MAPK100.38730001
133MAPK120.38432727
134MAPK140.37324011
135CLK10.36683321
136TBK10.36503629
137EGFR0.36411559
138TRPM70.36050425

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003102.19211256
2One carbon pool by folate_Homo sapiens_hsa006702.09671352
3Chronic myeloid leukemia_Homo sapiens_hsa052201.98071240
4Other glycan degradation_Homo sapiens_hsa005111.82223268
5Small cell lung cancer_Homo sapiens_hsa052221.81541104
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.78233539
7mTOR signaling pathway_Homo sapiens_hsa041501.64046347
8MicroRNAs in cancer_Homo sapiens_hsa052061.63606803
9Adherens junction_Homo sapiens_hsa045201.62797562
10Nitrogen metabolism_Homo sapiens_hsa009101.57595822
11Notch signaling pathway_Homo sapiens_hsa043301.57054915
12Central carbon metabolism in cancer_Homo sapiens_hsa052301.51524281
13Selenocompound metabolism_Homo sapiens_hsa004501.45473667
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.43364946
15ErbB signaling pathway_Homo sapiens_hsa040121.39388126
16Bladder cancer_Homo sapiens_hsa052191.37097010
17Insulin resistance_Homo sapiens_hsa049311.35817923
18Acute myeloid leukemia_Homo sapiens_hsa052211.35178596
19Proteoglycans in cancer_Homo sapiens_hsa052051.34946401
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.32152607
21Viral carcinogenesis_Homo sapiens_hsa052031.30765316
22Endometrial cancer_Homo sapiens_hsa052131.23622250
23Non-small cell lung cancer_Homo sapiens_hsa052231.20303353
24Systemic lupus erythematosus_Homo sapiens_hsa053221.18214797
25Arginine biosynthesis_Homo sapiens_hsa002201.17323145
26Focal adhesion_Homo sapiens_hsa045101.16703335
27Viral myocarditis_Homo sapiens_hsa054161.16275516
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.15061282
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14560416
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14223003
31Basal cell carcinoma_Homo sapiens_hsa052171.13621439
32mRNA surveillance pathway_Homo sapiens_hsa030151.13071016
33Choline metabolism in cancer_Homo sapiens_hsa052311.12152910
34Pancreatic cancer_Homo sapiens_hsa052121.11789114
35HTLV-I infection_Homo sapiens_hsa051661.10220957
36GnRH signaling pathway_Homo sapiens_hsa049121.09403443
37Inositol phosphate metabolism_Homo sapiens_hsa005621.07806719
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07678015
39Prion diseases_Homo sapiens_hsa050201.07117700
40Hippo signaling pathway_Homo sapiens_hsa043901.07090104
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05498810
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05092810
43Hepatitis C_Homo sapiens_hsa051601.04584330
44Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04169141
45Phospholipase D signaling pathway_Homo sapiens_hsa040721.03610094
46Toxoplasmosis_Homo sapiens_hsa051451.03090640
47B cell receptor signaling pathway_Homo sapiens_hsa046621.01223636
48Estrogen signaling pathway_Homo sapiens_hsa049151.01127131
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00322559
50Apoptosis_Homo sapiens_hsa042100.99804358
51AMPK signaling pathway_Homo sapiens_hsa041520.99180805
52Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98000077
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.97328512
54p53 signaling pathway_Homo sapiens_hsa041150.96471083
55Prostate cancer_Homo sapiens_hsa052150.96469015
56Thyroid cancer_Homo sapiens_hsa052160.96145625
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95414584
58Amoebiasis_Homo sapiens_hsa051460.93369068
59ECM-receptor interaction_Homo sapiens_hsa045120.91890942
60Pentose phosphate pathway_Homo sapiens_hsa000300.91700765
61Colorectal cancer_Homo sapiens_hsa052100.91319944
62Biosynthesis of amino acids_Homo sapiens_hsa012300.90975874
63Cell cycle_Homo sapiens_hsa041100.90951830
64Caffeine metabolism_Homo sapiens_hsa002320.89905783
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.87802018
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.87262397
67RNA transport_Homo sapiens_hsa030130.85801633
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85776401
69Herpes simplex infection_Homo sapiens_hsa051680.85706999
70Hepatitis B_Homo sapiens_hsa051610.85555008
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85031197
72Antigen processing and presentation_Homo sapiens_hsa046120.84115333
73Glioma_Homo sapiens_hsa052140.81599824
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80668364
75Prolactin signaling pathway_Homo sapiens_hsa049170.80607214
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.79463461
77HIF-1 signaling pathway_Homo sapiens_hsa040660.79167977
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78252707
79TGF-beta signaling pathway_Homo sapiens_hsa043500.77970759
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.77120062
81Fructose and mannose metabolism_Homo sapiens_hsa000510.76889706
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76749551
83Insulin signaling pathway_Homo sapiens_hsa049100.76351615
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76169598
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74939929
86Fat digestion and absorption_Homo sapiens_hsa049750.73755708
87FoxO signaling pathway_Homo sapiens_hsa040680.72952303
88Pathways in cancer_Homo sapiens_hsa052000.72572143
89Shigellosis_Homo sapiens_hsa051310.72235683
90Complement and coagulation cascades_Homo sapiens_hsa046100.71885680
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71492809
92Long-term potentiation_Homo sapiens_hsa047200.70278600
93Measles_Homo sapiens_hsa051620.70187554
94Type II diabetes mellitus_Homo sapiens_hsa049300.69635455
95Osteoclast differentiation_Homo sapiens_hsa043800.69430283
96Tryptophan metabolism_Homo sapiens_hsa003800.67854813
97TNF signaling pathway_Homo sapiens_hsa046680.67843666
98Leishmaniasis_Homo sapiens_hsa051400.66554626
99Endocytosis_Homo sapiens_hsa041440.66275478
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65648031
101PPAR signaling pathway_Homo sapiens_hsa033200.64365546
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.62786421
103Bile secretion_Homo sapiens_hsa049760.62534595
104Fatty acid degradation_Homo sapiens_hsa000710.62529928
105Platelet activation_Homo sapiens_hsa046110.62482519
106Legionellosis_Homo sapiens_hsa051340.61863451
107Fatty acid biosynthesis_Homo sapiens_hsa000610.61803873
108Influenza A_Homo sapiens_hsa051640.61770897
109Spliceosome_Homo sapiens_hsa030400.61716452
110Tight junction_Homo sapiens_hsa045300.60951028
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60709721
112Renal cell carcinoma_Homo sapiens_hsa052110.58998825
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58164741
114Salmonella infection_Homo sapiens_hsa051320.58014287
115Chemokine signaling pathway_Homo sapiens_hsa040620.57927498
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57818640
117Epstein-Barr virus infection_Homo sapiens_hsa051690.57368802
118Staphylococcus aureus infection_Homo sapiens_hsa051500.57262803
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57151731
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56725772
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.56615727
122MAPK signaling pathway_Homo sapiens_hsa040100.56447840
123Rap1 signaling pathway_Homo sapiens_hsa040150.56170174
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.56124688
125Tuberculosis_Homo sapiens_hsa051520.55888507
126VEGF signaling pathway_Homo sapiens_hsa043700.55441339
127ABC transporters_Homo sapiens_hsa020100.55367500
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55171374
129Glycosaminoglycan degradation_Homo sapiens_hsa005310.54174754
130Primary immunodeficiency_Homo sapiens_hsa053400.53731124
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52967674
132T cell receptor signaling pathway_Homo sapiens_hsa046600.52462399
133Galactose metabolism_Homo sapiens_hsa000520.52154227
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51883970
135Melanogenesis_Homo sapiens_hsa049160.50416895
136Melanoma_Homo sapiens_hsa052180.49872371

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