KDM5D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sphingosine metabolic process (GO:0006670)6.11475321
2meiotic chromosome segregation (GO:0045132)5.96892191
3diol metabolic process (GO:0034311)5.51119685
4negative regulation of keratinocyte proliferation (GO:0010839)5.35028668
5monoubiquitinated protein deubiquitination (GO:0035520)5.22746562
6negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.20106904
7positive regulation of gamma-delta T cell activation (GO:0046645)5.00102936
8mitotic metaphase plate congression (GO:0007080)4.81519074
9sphingoid metabolic process (GO:0046519)4.78527710
10piRNA metabolic process (GO:0034587)4.75367419
11female gonad development (GO:0008585)4.73605300
12regulation of establishment of cell polarity (GO:2000114)4.65312376
13female gamete generation (GO:0007292)4.62806942
14oocyte maturation (GO:0001556)4.61550896
15DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.61439293
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.52187706
17negative regulation of cell killing (GO:0031342)4.52187706
18negative regulation of hormone biosynthetic process (GO:0032353)4.41881041
19negative regulation of hormone metabolic process (GO:0032351)4.41881041
20regulation of meiosis I (GO:0060631)4.40208262
21regulation of keratinocyte proliferation (GO:0010837)4.39775417
22histone H3-K36 demethylation (GO:0070544)4.35060824
23DNA damage response, signal transduction resulting in transcription (GO:0042772)4.33992540
24regulation of meiosis (GO:0040020)4.20566079
25mitotic chromosome condensation (GO:0007076)4.07533572
26DNA damage induced protein phosphorylation (GO:0006975)4.05933753
27negative thymic T cell selection (GO:0045060)4.03293516
28male meiosis (GO:0007140)4.01040674
29regulation of retinoic acid receptor signaling pathway (GO:0048385)4.00424880
30negative regulation of meiosis (GO:0045835)3.99183909
31negative T cell selection (GO:0043383)3.98476188
32maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.96724656
33sister chromatid cohesion (GO:0007062)3.96508200
34metaphase plate congression (GO:0051310)3.94564483
35regulation of gamma-delta T cell activation (GO:0046643)3.86771261
36cellular response to gamma radiation (GO:0071480)3.83535694
37regulation of gamma-delta T cell differentiation (GO:0045586)3.75900616
38antigen processing and presentation of endogenous antigen (GO:0019883)3.75624219
39regulation of establishment or maintenance of cell polarity (GO:0032878)3.75007625
40positive thymic T cell selection (GO:0045059)3.74210941
41histone H2A monoubiquitination (GO:0035518)3.73573129
42regulation of exit from mitosis (GO:0007096)3.71746197
43microtubule depolymerization (GO:0007019)3.71544200
44positive T cell selection (GO:0043368)3.70993981
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.70403326
46antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.68998231
47snRNA transcription (GO:0009301)3.66561725
48regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.64042986
49mitotic sister chromatid cohesion (GO:0007064)3.55815422
50inner cell mass cell proliferation (GO:0001833)3.54293264
51meiotic cell cycle (GO:0051321)3.51970477
52N-terminal protein amino acid acetylation (GO:0006474)3.50455171
53establishment of chromosome localization (GO:0051303)3.47947098
54antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.47748003
55negative regulation of DNA-dependent DNA replication (GO:2000104)3.47240703
56regulation of B cell receptor signaling pathway (GO:0050855)3.43539068
57regulation of meiotic cell cycle (GO:0051445)3.40388121
58male meiosis I (GO:0007141)3.39966319
59nuclear pore complex assembly (GO:0051292)3.38722008
60paraxial mesoderm development (GO:0048339)3.38029608
61maturation of 5.8S rRNA (GO:0000460)3.37991068
62histone H3-K4 methylation (GO:0051568)3.37157424
63DNA methylation involved in gamete generation (GO:0043046)3.34965799
64attachment of spindle microtubules to kinetochore (GO:0008608)3.33780007
65notochord development (GO:0030903)3.32791528
66regulation of spindle organization (GO:0090224)3.32587988
67reciprocal meiotic recombination (GO:0007131)3.31097581
68reciprocal DNA recombination (GO:0035825)3.31097581
69regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.29295875
70myoblast migration (GO:0051451)3.27834831
71B cell receptor signaling pathway (GO:0050853)3.27572720
72T cell selection (GO:0045058)3.26313387
73T cell migration (GO:0072678)3.26072184
74negative regulation of erythrocyte differentiation (GO:0045647)3.25809629
75activated T cell proliferation (GO:0050798)3.23234603
76positive regulation of granulocyte differentiation (GO:0030854)3.19042061
77regulation of mitotic spindle organization (GO:0060236)3.18889488
78regulation of sister chromatid cohesion (GO:0007063)3.17575008
79replication fork processing (GO:0031297)3.17341067
80histone H3-K9 demethylation (GO:0033169)3.15128153
81positive regulation of B cell differentiation (GO:0045579)3.15083944
82resolution of meiotic recombination intermediates (GO:0000712)3.14960375
83protein K6-linked ubiquitination (GO:0085020)3.13710483
84regulation of transcription from RNA polymerase I promoter (GO:0006356)3.12879976
85kinetochore assembly (GO:0051382)3.11118027
86mismatch repair (GO:0006298)3.10745913
87regulation of histone H3-K27 methylation (GO:0061085)3.09913789
88chromosome segregation (GO:0007059)3.09442333
89negative regulation of cell aging (GO:0090344)3.08495984
90glycerophospholipid catabolic process (GO:0046475)3.08430992
91positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.08075796
92histone H3-K9 methylation (GO:0051567)3.07888264
93meiosis I (GO:0007127)3.06008773
94immunoglobulin mediated immune response (GO:0016064)3.04133709
95thymic T cell selection (GO:0045061)3.03589129
96microtubule nucleation (GO:0007020)3.01415072
97interkinetic nuclear migration (GO:0022027)3.01315663
98germinal center formation (GO:0002467)3.01151489
99negative regulation of lymphocyte mediated immunity (GO:0002707)2.99378166
100regulation of glucocorticoid metabolic process (GO:0031943)2.94380171
101cellular extravasation (GO:0045123)2.92323363
102DNA synthesis involved in DNA repair (GO:0000731)2.92054093
103regulation of B cell differentiation (GO:0045577)2.91128112
104type B pancreatic cell development (GO:0003323)2.89007225
105response to interleukin-15 (GO:0070672)2.88715387
106regulation of germinal center formation (GO:0002634)2.88664632
107centriole replication (GO:0007099)2.87867029
108positive regulation of DNA-dependent DNA replication (GO:2000105)2.86487072
109positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.83782935
110positive regulation by symbiont of host defense response (GO:0052509)2.83683555
111modulation by symbiont of host defense response (GO:0052031)2.83683555
112modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.83683555
113modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.83683555
114positive regulation by organism of defense response of other organism involved in symbiotic interact2.83683555
115modulation by symbiont of host immune response (GO:0052553)2.83683555
116negative regulation of circadian rhythm (GO:0042754)2.82493634
117positive regulation of Rap GTPase activity (GO:0032854)2.82383564
118detection of other organism (GO:0098543)2.81779536
119negative regulation of T cell mediated immunity (GO:0002710)2.81740800
120regulation of double-strand break repair via homologous recombination (GO:0010569)2.81702253
121cellular response to ethanol (GO:0071361)2.80312736
122DNA alkylation (GO:0006305)2.78805878
123DNA methylation (GO:0006306)2.78805878
124regulation of female gonad development (GO:2000194)2.76223119
125positive regulation of meiosis (GO:0045836)2.76092570
126mitotic sister chromatid segregation (GO:0000070)2.75760272
127detection of bacterium (GO:0016045)2.74823718
128negative regulation of leukocyte mediated immunity (GO:0002704)2.73966401
129peptidyl-lysine trimethylation (GO:0018023)2.73148952
130regulation of T cell tolerance induction (GO:0002664)2.72964998
131histone lysine methylation (GO:0034968)2.72547113
132histone H2A ubiquitination (GO:0033522)2.71966261
133meiotic cell cycle process (GO:1903046)2.71248801
134negative regulation of alcohol biosynthetic process (GO:1902931)2.70138880
135regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.69830434
136regulation of mitotic spindle checkpoint (GO:1903504)2.69830434
137interferon-gamma-mediated signaling pathway (GO:0060333)2.68470688
138centriole assembly (GO:0098534)2.68097464
139positive regulation of meiotic cell cycle (GO:0051446)2.66955920
140positive regulation of mitotic sister chromatid separation (GO:1901970)2.66325190
141positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.66325190
142positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.66325190
143oogenesis (GO:0048477)2.64814912
144regulation of keratinocyte differentiation (GO:0045616)2.63961227
145response to peptidoglycan (GO:0032494)2.60694850
146macrophage activation involved in immune response (GO:0002281)2.58176022
147regulation of tolerance induction (GO:0002643)2.57737138
148regulation of granulocyte differentiation (GO:0030852)2.56413526
149mannose metabolic process (GO:0006013)2.54813345
150negative regulation of interleukin-12 production (GO:0032695)2.54246521
151B cell homeostasis (GO:0001782)2.52395268
152plasma lipoprotein particle assembly (GO:0034377)2.51599471
153regulation of dendritic cell antigen processing and presentation (GO:0002604)2.51288422
154leukocyte aggregation (GO:0070486)2.48764830
155phospholipid translocation (GO:0045332)2.48457450
156lipid translocation (GO:0034204)2.48457450
157negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.47365139
158antigen receptor-mediated signaling pathway (GO:0050851)2.47237856
159regulation of myeloid leukocyte mediated immunity (GO:0002886)2.45616254
160regulation of ARF protein signal transduction (GO:0032012)2.44487581
161positive regulation of antigen processing and presentation (GO:0002579)2.44483079
162negative regulation of protein oligomerization (GO:0032460)2.43547506
163regulation of Rap GTPase activity (GO:0032317)2.43339339
164detection of external biotic stimulus (GO:0098581)2.43275831
165protein-lipid complex assembly (GO:0065005)2.41860953
166response to muramyl dipeptide (GO:0032495)2.41320042
167positive regulation of tolerance induction (GO:0002645)2.40213027
168negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.39097109
169nerve growth factor signaling pathway (GO:0038180)2.38888050
170cellular response to interleukin-15 (GO:0071350)2.35543019
171tolerance induction (GO:0002507)2.35541470
172positive regulation of chemokine secretion (GO:0090197)2.35024069
173regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.34639698
174Peyers patch development (GO:0048541)2.32762301
175mucosal-associated lymphoid tissue development (GO:0048537)2.32762301
176cholesterol efflux (GO:0033344)2.32749907
177neutrophil activation involved in immune response (GO:0002283)2.32498748
178neurotransmitter-gated ion channel clustering (GO:0072578)2.31112232
179negative regulation of adaptive immune response (GO:0002820)2.30467509
180regulation of antigen processing and presentation (GO:0002577)2.29795921
181T cell receptor signaling pathway (GO:0050852)2.29438766
182regulation of mast cell degranulation (GO:0043304)2.28376196
183neutrophil activation (GO:0042119)2.25886584
184regulation of macrophage chemotaxis (GO:0010758)2.25211556
185negative regulation of glycoprotein biosynthetic process (GO:0010561)2.22440626
186phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.21915294
187detection of molecule of bacterial origin (GO:0032490)2.21585339
188microglial cell activation (GO:0001774)2.21324057
189regulation of mast cell activation involved in immune response (GO:0033006)2.20754098
190negative regulation of immunoglobulin mediated immune response (GO:0002890)2.20078327
191negative regulation of B cell mediated immunity (GO:0002713)2.20078327
192regulation of leukocyte degranulation (GO:0043300)2.19513281
193phospholipid efflux (GO:0033700)2.16976688
194positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.16521049
195regulation of alpha-beta T cell proliferation (GO:0046640)2.15675295
196negative regulation of innate immune response (GO:0045824)2.15567621
197type I interferon signaling pathway (GO:0060337)2.15112400
198cellular response to type I interferon (GO:0071357)2.15112400

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.62287485
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.85056890
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.77308302
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.40058184
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.10290571
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.99373456
7RUNX_20019798_ChIP-Seq_JUKART_Human2.94002604
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.87996621
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.83587934
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.72986911
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.71100510
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.62779954
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.56364081
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.52440165
15E2F7_22180533_ChIP-Seq_HELA_Human2.52279594
16KAP1_22055183_ChIP-Seq_ESCs_Mouse2.50590592
17* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.44284361
18GBX2_23144817_ChIP-Seq_PC3_Human2.43520811
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.42669575
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.38219266
21IGF1R_20145208_ChIP-Seq_DFB_Human2.27316797
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.26842188
23IRF8_21731497_ChIP-ChIP_J774_Mouse2.26141776
24IRF8_27001747_Chip-Seq_BMDM_Mouse2.25457209
25SCL_19346495_ChIP-Seq_HPC-7_Human2.21458265
26SUZ12_27294783_Chip-Seq_NPCs_Mouse2.20187357
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18441589
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13891134
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.13665954
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.12668701
31NANOG_18555785_Chip-Seq_ESCs_Mouse2.05141751
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.03816019
33NFE2_27457419_Chip-Seq_LIVER_Mouse2.03112001
34ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02610801
35TP63_19390658_ChIP-ChIP_HaCaT_Human2.01642238
36FUS_26573619_Chip-Seq_HEK293_Human1.93921323
37TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.91794896
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.89319748
39VDR_24787735_ChIP-Seq_THP-1_Human1.87785148
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.86705345
41DROSHA_22980978_ChIP-Seq_HELA_Human1.86384998
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.86140985
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.80332412
44POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.76861340
45TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76861340
46MYB_26560356_Chip-Seq_TH2_Human1.75398012
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75322552
48EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.73421942
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.71037506
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.65597020
51SPI1_23127762_ChIP-Seq_K562_Human1.63891195
52E2F1_18555785_Chip-Seq_ESCs_Mouse1.63618280
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63136429
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.62249247
55STAT3_18555785_Chip-Seq_ESCs_Mouse1.60529289
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59068911
57RNF2_27304074_Chip-Seq_NSC_Mouse1.58903745
58STAT3_23295773_ChIP-Seq_U87_Human1.58719226
59SUZ12_18555785_Chip-Seq_ESCs_Mouse1.57689495
60LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56858283
61IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.56399525
62CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55733639
63EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.55704847
64GATA3_27048872_Chip-Seq_THYMUS_Human1.55373257
65P53_22387025_ChIP-Seq_ESCs_Mouse1.55324446
66SOX2_18555785_Chip-Seq_ESCs_Mouse1.54921372
67VDR_24763502_ChIP-Seq_THP-1_Human1.52675736
68CMYC_18555785_Chip-Seq_ESCs_Mouse1.52522615
69NMYC_18555785_Chip-Seq_ESCs_Mouse1.51315547
70TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.50707745
71GATA1_19941827_ChIP-Seq_MEL_Mouse1.50625654
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.49721048
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47321777
74GATA1_26923725_Chip-Seq_HPCs_Mouse1.46717805
75OCT4_18555785_Chip-Seq_ESCs_Mouse1.46217403
76TAF15_26573619_Chip-Seq_HEK293_Human1.44964900
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44203443
78FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.42273186
79SMAD4_21799915_ChIP-Seq_A2780_Human1.42202736
80ZFX_18555785_Chip-Seq_ESCs_Mouse1.41952026
81TBL1_22424771_ChIP-Seq_293T_Human1.41257459
82SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39326800
83P300_18555785_Chip-Seq_ESCs_Mouse1.37520500
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36535791
85KLF4_18555785_Chip-Seq_ESCs_Mouse1.36452300
86RUNX1_26923725_Chip-Seq_HPCs_Mouse1.36420004
87KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35996298
88MYB_26560356_Chip-Seq_TH1_Human1.35289051
89TCF7_22412390_ChIP-Seq_EML_Mouse1.35092965
90ESRRB_18555785_Chip-Seq_ESCs_Mouse1.34747542
91KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34419542
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.34191280
93EWS_26573619_Chip-Seq_HEK293_Human1.34175088
94CTCF_18555785_Chip-Seq_ESCs_Mouse1.33129119
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.32001744
96EGR1_19374776_ChIP-ChIP_THP-1_Human1.31554313
97MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31329420
98OCT4_21477851_ChIP-Seq_ESCs_Mouse1.31121468
99KDM2B_26808549_Chip-Seq_DND41_Human1.30259459
100P300_19829295_ChIP-Seq_ESCs_Human1.30021798
101TCF4_23295773_ChIP-Seq_U87_Human1.29958152
102UTX_26944678_Chip-Seq_JUKART_Human1.29546906
103GATA2_21666600_ChIP-Seq_HMVEC_Human1.29138520
104RUNX1_27457419_Chip-Seq_LIVER_Mouse1.27838785
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27137343
106MAF_26560356_Chip-Seq_TH1_Human1.25897976
107NFYA_21822215_ChIP-Seq_K562_Human1.25443795
108CRX_20693478_ChIP-Seq_RETINA_Mouse1.23782675
109GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23183830
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21712554
111CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.21035429
112MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20692048
113TAL1_26923725_Chip-Seq_HPCs_Mouse1.20372547
114FOXA2_19822575_ChIP-Seq_HepG2_Human1.20156118
115CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18731767
116ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17963542
117PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17707512
118STAT1_17558387_ChIP-Seq_HELA_Human1.17266059
119STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16603889
120VDR_21846776_ChIP-Seq_THP-1_Human1.16400567
121AR_25329375_ChIP-Seq_VCAP_Human1.16297298
122PU1_27457419_Chip-Seq_LIVER_Mouse1.15482273
123GATA1_19941826_ChIP-Seq_K562_Human1.15265719
124BP1_19119308_ChIP-ChIP_Hs578T_Human1.14642268
125SMAD1_18555785_Chip-Seq_ESCs_Mouse1.13630308
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12721994
127SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12277555
128KDM2B_26808549_Chip-Seq_REH_Human1.12004905
129LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11992106
130IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11845373
131SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11743617
132FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11510303
133TP53_16413492_ChIP-PET_HCT116_Human1.10833091
134RUNX1_22412390_ChIP-Seq_EML_Mouse1.07519638
135PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07293472
136ESR1_20079471_ChIP-ChIP_T-47D_Human1.07210406
137CBX2_27304074_Chip-Seq_ESCs_Mouse1.06871801
138* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06633882
139HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06284001
140GATA3_26560356_Chip-Seq_TH2_Human1.06216376
141MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05615871
142CDX2_22108803_ChIP-Seq_LS180_Human1.05476896
143KDM2B_26808549_Chip-Seq_JURKAT_Human1.05394448
144ETV1_20927104_ChIP-Seq_GIST48_Human1.04548745
145TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04430613
146LXR_22158963_ChIP-Seq_LIVER_Mouse1.03984480
147BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03841233
148GF1_26923725_Chip-Seq_HPCs_Mouse1.03414702
149THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02745989
150PRDM14_20953172_ChIP-Seq_ESCs_Human1.02486531
151KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02414676
152NFYB_21822215_ChIP-Seq_K562_Human1.02293028
153UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01680982
154SPI1_23547873_ChIP-Seq_NB4_Human1.01041873
155AR_21572438_ChIP-Seq_LNCaP_Human1.00847990
156CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99979914
157HNFA_21074721_ChIP-Seq_CACO-2_Human0.99918303
158GATA2_19941826_ChIP-Seq_K562_Human0.99531321
159LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99392576
160FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99295996
161RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94583900
162GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.93442974
163RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92563499
164NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92550328
165FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.91492681
166PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90999177
167MYC_22102868_ChIP-Seq_BL_Human0.90267991
168EZH2_22144423_ChIP-Seq_EOC_Human0.87735735
169NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.87720616
170BRD4_27068464_Chip-Seq_AML-cells_Mouse0.86775100
171GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85234616
172MAF_26560356_Chip-Seq_TH2_Human0.82033347
173PU_27001747_Chip-Seq_BMDM_Mouse0.81747199
174SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81144996
175NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.79830078
176DNAJC2_21179169_ChIP-ChIP_NT2_Human0.78404476
177WT1_25993318_ChIP-Seq_PODOCYTE_Human0.75752136
178REST_21632747_ChIP-Seq_MESCs_Mouse0.75454812
179TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.74156735
180KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.73568363
181SMRT_27268052_Chip-Seq_Bcells_Human0.73417302
182FOXO3_23340844_ChIP-Seq_DLD1_Human0.71737615
183CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.71413737
184VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.68895409
185ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.68166999

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition4.88777995
2MP0003787_abnormal_imprinting4.15585941
3MP0002102_abnormal_ear_morphology3.91216865
4MP0000569_abnormal_digit_pigmentation3.59881380
5MP0006292_abnormal_olfactory_placode3.53546669
6MP0000566_synostosis3.48050050
7MP0008877_abnormal_DNA_methylation3.33766101
8MP0001835_abnormal_antigen_presentation3.19442646
9MP0003436_decreased_susceptibility_to3.08153277
10MP0003303_peritoneal_inflammation2.97434086
11MP0003172_abnormal_lysosome_physiology2.91463328
12MP0003724_increased_susceptibility_to2.86806638
13MP0003718_maternal_effect2.85778754
14MP0003111_abnormal_nucleus_morphology2.70448850
15MP0003693_abnormal_embryo_hatching2.66513792
16MP0005387_immune_system_phenotype2.57150911
17MP0001790_abnormal_immune_system2.57150911
18MP0001800_abnormal_humoral_immune2.55825533
19MP0008057_abnormal_DNA_replication2.54951762
20MP0005408_hypopigmentation2.47287014
21MP0003077_abnormal_cell_cycle2.44915111
22MP0003646_muscle_fatigue2.42563033
23MP0000685_abnormal_immune_system2.38494691
24MP0006082_CNS_inflammation2.38031345
25MP0010094_abnormal_chromosome_stability2.29243836
26MP0003937_abnormal_limbs/digits/tail_de2.28593934
27MP0003300_gastrointestinal_ulcer2.28131132
28MP0005671_abnormal_response_to2.26616602
29MP0005000_abnormal_immune_tolerance2.25292614
30MP0002419_abnormal_innate_immunity2.21285153
31MP0008007_abnormal_cellular_replicative2.20283372
32MP0005646_abnormal_pituitary_gland2.17909303
33MP0005025_abnormal_response_to2.16330653
34MP0009840_abnormal_foam_cell2.14762310
35MP0008058_abnormal_DNA_repair2.11051451
36MP0002723_abnormal_immune_serum2.09959154
37MP0001119_abnormal_female_reproductive2.07645751
38MP0002653_abnormal_ependyma_morphology2.06266273
39MP0003690_abnormal_glial_cell2.03733610
40MP0000579_abnormal_nail_morphology2.02254997
41MP0002420_abnormal_adaptive_immunity1.99944708
42MP0002452_abnormal_antigen_presenting1.99703580
43MP0001819_abnormal_immune_cell1.96802714
44MP0005464_abnormal_platelet_physiology1.92806535
45MP0010155_abnormal_intestine_physiology1.90952830
46MP0009785_altered_susceptibility_to1.86642621
47MP0003121_genomic_imprinting1.81500138
48MP0003699_abnormal_female_reproductive1.78936801
49MP0000604_amyloidosis1.76248106
50MP0002210_abnormal_sex_determination1.73859325
51MP0001501_abnormal_sleep_pattern1.72741229
52MP0001929_abnormal_gametogenesis1.71867154
53MP0003890_abnormal_embryonic-extraembry1.68273488
54MP0002396_abnormal_hematopoietic_system1.62849864
55MP0002009_preneoplasia1.61901780
56MP0003191_abnormal_cellular_cholesterol1.60155209
57MP0005167_abnormal_blood-brain_barrier1.59991318
58MP0002148_abnormal_hypersensitivity_rea1.58851444
59MP0000716_abnormal_immune_system1.55028936
60MP0009278_abnormal_bone_marrow1.54928851
61MP0000653_abnormal_sex_gland1.54217388
62MP0005310_abnormal_salivary_gland1.53735898
63MP0002405_respiratory_system_inflammati1.52964683
64MP0005395_other_phenotype1.51598355
65MP0005058_abnormal_lysosome_morphology1.49899971
66MP0001346_abnormal_lacrimal_gland1.49306340
67MP0002166_altered_tumor_susceptibility1.49226313
68MP0003866_abnormal_defecation1.48288762
69MP0002249_abnormal_larynx_morphology1.47840623
70MP0002398_abnormal_bone_marrow1.45342285
71MP0004947_skin_inflammation1.44706982
72MP0002163_abnormal_gland_morphology1.44200417
73MP0001533_abnormal_skeleton_physiology1.42338871
74MP0001188_hyperpigmentation1.41446450
75MP0003183_abnormal_peptide_metabolism1.40820528
76MP0001845_abnormal_inflammatory_respons1.38904847
77MP0005647_abnormal_sex_gland1.37778536
78MP0000383_abnormal_hair_follicle1.37778474
79MP0003122_maternal_imprinting1.35275446
80MP0002998_abnormal_bone_remodeling1.32179238
81MP0000465_gastrointestinal_hemorrhage1.30438077
82MP0010307_abnormal_tumor_latency1.29137175
83MP0009764_decreased_sensitivity_to1.28623964
84MP0000689_abnormal_spleen_morphology1.28421733
85MP0003868_abnormal_feces_composition1.26957291
86MP0002933_joint_inflammation1.26604512
87MP0002139_abnormal_hepatobiliary_system1.25012331
88MP0001145_abnormal_male_reproductive1.22076073
89MP0003329_amyloid_beta_deposits1.20729441
90MP0005360_urolithiasis1.20322225
91MP0008995_early_reproductive_senescence1.19579923
92MP0000639_abnormal_adrenal_gland1.17446908
93MP0002722_abnormal_immune_system1.16537402
94MP0008469_abnormal_protein_level1.16326257
95MP0005365_abnormal_bile_salt1.16054172
96MP0003656_abnormal_erythrocyte_physiolo1.14900350
97MP0003075_altered_response_to1.13780745
98MP0003755_abnormal_palate_morphology1.12326326
99MP0001986_abnormal_taste_sensitivity1.11840571
100MP0010329_abnormal_lipoprotein_level1.10375258
101MP0000427_abnormal_hair_cycle1.09151788
102MP0003315_abnormal_perineum_morphology1.08871426
103MP0004270_analgesia1.08588158
104MP0002429_abnormal_blood_cell1.08136773
105MP0000703_abnormal_thymus_morphology1.08115472
106MP0000462_abnormal_digestive_system1.06568940
107MP0004883_abnormal_blood_vessel1.06330798
108MP0005379_endocrine/exocrine_gland_phen1.04866372
109MP0000920_abnormal_myelination1.04214211
110MP0004859_abnormal_synaptic_plasticity1.03513809
111MP0000538_abnormal_urinary_bladder1.03504049
112MP0000490_abnormal_crypts_of1.01289752
113MP0002277_abnormal_respiratory_mucosa1.00028199
114MP0009333_abnormal_splenocyte_physiolog0.99112948
115MP0004185_abnormal_adipocyte_glucose0.98827274
116MP0003763_abnormal_thymus_physiology0.98786239
117MP0005248_abnormal_Harderian_gland0.98391293
118MP0000432_abnormal_head_morphology0.97707148
119MP0004043_abnormal_pH_regulation0.96266112
120MP0008004_abnormal_stomach_pH0.95863062
121MP0004264_abnormal_extraembryonic_tissu0.95771629
122MP0001851_eye_inflammation0.95695465
123MP0000350_abnormal_cell_proliferation0.95643524
124MP0002177_abnormal_outer_ear0.94540367
125MP0003123_paternal_imprinting0.93743843
126MP0001529_abnormal_vocalization0.93051338
127MP0000613_abnormal_salivary_gland0.91443310
128MP0003698_abnormal_male_reproductive0.91304205
129MP0009697_abnormal_copulation0.91269026
130MP0004381_abnormal_hair_follicle0.91028665
131MP0008569_lethality_at_weaning0.90781607
132MP0008260_abnormal_autophagy0.90766576
133MP0003828_pulmonary_edema0.89615221
134MP0002085_abnormal_embryonic_tissue0.89442382
135MP0002161_abnormal_fertility/fecundity0.88907000
136MP0000015_abnormal_ear_pigmentation0.88541426
137MP0001984_abnormal_olfaction0.87703340
138MP0003935_abnormal_craniofacial_develop0.87374997
139MP0000249_abnormal_blood_vessel0.87269383
140MP0004130_abnormal_muscle_cell0.87248408
141MP0005535_abnormal_body_temperature0.87132970
142MP0003632_abnormal_nervous_system0.87125491
143MP0002138_abnormal_hepatobiliary_system0.86926308
144MP0009250_abnormal_appendicular_skeleto0.86476770
145MP0005166_decreased_susceptibility_to0.86323591
146MP0005257_abnormal_intraocular_pressure0.86025954
147MP0003633_abnormal_nervous_system0.85992663
148MP0002064_seizures0.84611214
149MP0002233_abnormal_nose_morphology0.84561759
150MP0005187_abnormal_penis_morphology0.82555625
151MP0001873_stomach_inflammation0.80890374
152MP0010386_abnormal_urinary_bladder0.80074365
153MP0005085_abnormal_gallbladder_physiolo0.79884673
154MP0003136_yellow_coat_color0.79798930
155MP0002109_abnormal_limb_morphology0.78338940
156MP0003252_abnormal_bile_duct0.77365912
157MP0000767_abnormal_smooth_muscle0.77222403
158MP0002638_abnormal_pupillary_reflex0.77085482
159MP0001958_emphysema0.76871715
160MP0009115_abnormal_fat_cell0.76354874
161MP0002006_tumorigenesis0.75703885
162MP0000631_abnormal_neuroendocrine_gland0.75251735
163MP0003879_abnormal_hair_cell0.74578805
164MP0001663_abnormal_digestive_system0.74152176
165MP0002877_abnormal_melanocyte_morpholog0.74141669
166MP0002084_abnormal_developmental_patter0.73151717
167MP0003091_abnormal_cell_migration0.72307415
168MP0010678_abnormal_skin_adnexa0.71600531
169MP0001486_abnormal_startle_reflex0.71541824
170MP0004808_abnormal_hematopoietic_stem0.71435454
171MP0000627_abnormal_mammary_gland0.71339371
172MP0002168_other_aberrant_phenotype0.71179585
173MP0002928_abnormal_bile_duct0.70929753
174MP0001666_abnormal_nutrient_absorption0.70024149
175MP0002116_abnormal_craniofacial_bone0.69532489
176MP0003880_abnormal_central_pattern0.69041436
177MP0008961_abnormal_basal_metabolism0.68925009
178MP0001853_heart_inflammation0.68102153
179MP0005621_abnormal_cell_physiology0.67580023
180MP0005380_embryogenesis_phenotype0.66548576
181MP0001672_abnormal_embryogenesis/_devel0.66548576
182MP0003938_abnormal_ear_development0.65931126
183MP0001186_pigmentation_phenotype0.62931321
184MP0001545_abnormal_hematopoietic_system0.62517725
185MP0005397_hematopoietic_system_phenotyp0.62517725
186MP0003385_abnormal_body_wall0.62317054
187MP0002160_abnormal_reproductive_system0.61667391

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.53690370
2Chromsome breakage (HP:0040012)6.20889357
3Papillary thyroid carcinoma (HP:0002895)6.04565149
4Prostate neoplasm (HP:0100787)5.30052669
5Abnormality of the fingertips (HP:0001211)4.45018698
6Male infertility (HP:0003251)4.42105951
7Eczematoid dermatitis (HP:0000976)4.36979848
8Abnormal delayed hypersensitivity skin test (HP:0002963)4.00816103
9Systemic lupus erythematosus (HP:0002725)3.65363956
10Lip pit (HP:0100267)3.64206865
11Facial hemangioma (HP:0000329)3.55387545
12Acute myeloid leukemia (HP:0004808)3.51975053
13Aplasia/Hypoplasia of the uvula (HP:0010293)3.48605649
14Papilledema (HP:0001085)3.48313357
15Ectopic kidney (HP:0000086)3.43217952
16Thyroid carcinoma (HP:0002890)3.41048603
17Myositis (HP:0100614)3.37638844
18Panhypogammaglobulinemia (HP:0003139)3.35473234
19Abnormality of chromosome stability (HP:0003220)3.34731137
20Recurrent fungal infections (HP:0002841)3.33657204
21Elevated erythrocyte sedimentation rate (HP:0003565)3.30428562
22Recurrent gram-negative bacterial infections (HP:0005420)3.27037181
23Recurrent cutaneous fungal infections (HP:0011370)3.26252652
24Chronic mucocutaneous candidiasis (HP:0002728)3.26252652
25Gingival bleeding (HP:0000225)3.24626263
26Recurrent bacterial skin infections (HP:0005406)3.23595143
27Abnormality of the preputium (HP:0100587)3.19272614
28Meckel diverticulum (HP:0002245)3.18511115
29Abnormality of macrophages (HP:0004311)3.13990413
30Shawl scrotum (HP:0000049)3.11731256
31Stomatitis (HP:0010280)3.07668568
32Pustule (HP:0200039)3.07582070
33Birth length less than 3rd percentile (HP:0003561)3.07198351
34Capillary hemangiomas (HP:0005306)3.05271487
35Orchitis (HP:0100796)3.05069333
36Clubbing of toes (HP:0100760)3.03639260
37Complement deficiency (HP:0004431)3.03364465
38Vasculitis (HP:0002633)3.01166663
39Abnormality of the ileum (HP:0001549)3.00385891
40Recurrent abscess formation (HP:0002722)2.99276350
41Agammaglobulinemia (HP:0004432)2.99264054
42Gastrointestinal infarctions (HP:0005244)2.97388333
43Spontaneous hematomas (HP:0007420)2.95362179
44Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.94948491
45Flat capital femoral epiphysis (HP:0003370)2.94697257
46Pulmonary infiltrates (HP:0002113)2.92774070
47Abnormality of the prostate (HP:0008775)2.88822732
48Hematochezia (HP:0002573)2.87998429
49T lymphocytopenia (HP:0005403)2.87470998
50Glomerulonephritis (HP:0000099)2.87284111
51Mediastinal lymphadenopathy (HP:0100721)2.86128771
52Encephalitis (HP:0002383)2.84117249
53Abnormality of the labia minora (HP:0012880)2.82787586
54Meningitis (HP:0001287)2.82067229
55Adrenal hypoplasia (HP:0000835)2.81690644
56Abnormality of T cell number (HP:0011839)2.81525263
57Patellar aplasia (HP:0006443)2.76050000
58Colitis (HP:0002583)2.75884306
59Recurrent skin infections (HP:0001581)2.73316442
60Oligodactyly (hands) (HP:0001180)2.66697481
61Abnormality of the carotid arteries (HP:0005344)2.66003743
62Prolonged bleeding time (HP:0003010)2.64654341
63Recurrent viral infections (HP:0004429)2.61471629
64Leukocytosis (HP:0001974)2.58641245
65Epistaxis (HP:0000421)2.55056920
66Inflammation of the large intestine (HP:0002037)2.53321957
67Midline defect of the nose (HP:0004122)2.52952526
68Aplasia/Hypoplasia of the patella (HP:0006498)2.47912754
69Stomach cancer (HP:0012126)2.46574186
70Aplasia/Hypoplasia of the fovea (HP:0008060)2.45938385
71Hypoplasia of the fovea (HP:0007750)2.45938385
72Increased IgM level (HP:0003496)2.45673527
73Chest pain (HP:0100749)2.45169046
74Gastrointestinal inflammation (HP:0004386)2.41660359
75Hemiplegia (HP:0002301)2.35829097
76Pulmonary embolism (HP:0002204)2.35592182
77Viral hepatitis (HP:0006562)2.34748744
78Increased IgE level (HP:0003212)2.32150731
79Breast aplasia (HP:0100783)2.31865594
80Episodic fever (HP:0001954)2.29950960
81Gingivitis (HP:0000230)2.29707905
82Hemoptysis (HP:0002105)2.29692323
83Insulin-resistant diabetes mellitus (HP:0000831)2.27975435
84Abnormality of complement system (HP:0005339)2.27621449
85Chronic diarrhea (HP:0002028)2.26771557
86Myelodysplasia (HP:0002863)2.25739506
87Febrile seizures (HP:0002373)2.23324216
88Cellulitis (HP:0100658)2.21951186
89Aplasia/Hypoplasia of the breasts (HP:0010311)2.21082180
90Dysostosis multiplex (HP:0000943)2.16230239
91Abnormality of T cells (HP:0002843)2.16175511
92Acute lymphatic leukemia (HP:0006721)2.15787804
93Keratoconjunctivitis sicca (HP:0001097)2.14084748
94Short thumb (HP:0009778)2.14004592
95Small intestinal stenosis (HP:0012848)2.13136924
96Duodenal stenosis (HP:0100867)2.13136924
97Deep venous thrombosis (HP:0002625)2.10656088
98Sensorimotor neuropathy (HP:0007141)2.09741989
99Azoospermia (HP:0000027)2.09501526
100Anal stenosis (HP:0002025)2.08455590
101Oligodactyly (HP:0012165)2.08283517
102Abnormality of the pleura (HP:0002103)2.07915978
103Pancreatic fibrosis (HP:0100732)2.05456760
104Abnormality of the periventricular white matter (HP:0002518)2.05441411
105Abnormal hair whorl (HP:0010721)2.05088253
106Anterior segment dysgenesis (HP:0007700)2.04938938
107Hemorrhage of the eye (HP:0011885)2.02842611
108Abnormality of chromosome segregation (HP:0002916)2.02782887
109Abnormality of male internal genitalia (HP:0000022)2.02758467
110Abnormality of glycolipid metabolism (HP:0010969)2.02514072
111Abnormality of liposaccharide metabolism (HP:0010968)2.02514072
112Abnormality of glycosphingolipid metabolism (HP:0004343)2.02514072
113Hypergammaglobulinemia (HP:0010702)2.02291200
114Absent speech (HP:0001344)2.01910493
115Obstructive lung disease (HP:0006536)2.01310462
116Chronic obstructive pulmonary disease (HP:0006510)2.01310462
117Abnormality of incisor morphology (HP:0011063)2.01145045
118Long eyelashes (HP:0000527)2.00374897
119Lymphopenia (HP:0001888)1.97564680
120Abnormality of lateral ventricle (HP:0030047)1.96200891
121Mucopolysacchariduria (HP:0008155)1.96006897
122Urinary glycosaminoglycan excretion (HP:0003541)1.96006897
123Loss of speech (HP:0002371)1.95967601
124Abnormality of the fovea (HP:0000493)1.94935534
125Diplopia (HP:0000651)1.93943665
126Abnormality of binocular vision (HP:0011514)1.93943665
127Abnormality of mucopolysaccharide metabolism (HP:0011020)1.93884440
128Abnormality of polysaccharide metabolism (HP:0011012)1.93884440
129Abnormality of glycosaminoglycan metabolism (HP:0004371)1.93884440
130Abnormality of DNA repair (HP:0003254)1.92614456
131Neoplasm of the tracheobronchial system (HP:0100552)1.92191135
132Widely spaced teeth (HP:0000687)1.92053382
133Joint swelling (HP:0001386)1.91688258
134Breast hypoplasia (HP:0003187)1.91327700
135Purpura (HP:0000979)1.91149174
136Keratoconjunctivitis (HP:0001096)1.91052942
137Abnormality of the phalanges of the hallux (HP:0010057)1.90348176
138Peritonitis (HP:0002586)1.89717061
139Overlapping toe (HP:0001845)1.89303288
140Osteomyelitis (HP:0002754)1.88654387
141Heterotopia (HP:0002282)1.87571019
142Increased cerebral lipofuscin (HP:0011813)1.87403063
143Spastic gait (HP:0002064)1.86888683
144Eosinophilia (HP:0001880)1.86705246
145Abnormal spermatogenesis (HP:0008669)1.86248331
146Alveolar cell carcinoma (HP:0006519)1.86204635
147Abnormality of eosinophils (HP:0001879)1.86203336
148Urethral obstruction (HP:0000796)1.84856492
149Granulocytopenia (HP:0001913)1.84646358
150Restrictive lung disease (HP:0002091)1.84065100
151Joint hemorrhage (HP:0005261)1.83762496
152Abnormality of cells of the lymphoid lineage (HP:0012140)1.82899022
153Abnormality of the renal collecting system (HP:0004742)1.82436339
154Papilloma (HP:0012740)1.81997306
155Verrucae (HP:0200043)1.81997306
156Gastrointestinal stroma tumor (HP:0100723)1.81703566
157Nephroblastoma (Wilms tumor) (HP:0002667)1.81585548
158Aplasia/Hypoplasia of the macula (HP:0008059)1.81468170
159Optic neuritis (HP:0100653)1.80146100
160Retrobulbar optic neuritis (HP:0100654)1.80146100
161Hypoplastic iliac wings (HP:0002866)1.79738627
162Microglossia (HP:0000171)1.79675333
163Neurofibrillary tangles (HP:0002185)1.79353514
164Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.78120605
165Inappropriate behavior (HP:0000719)1.78040550
166Increased CSF protein (HP:0002922)1.77547316
167Ectropion (HP:0000656)1.77067924
168Hyperkalemia (HP:0002153)1.76518665
169Sparse lateral eyebrow (HP:0005338)1.75466602
170Sandal gap (HP:0001852)1.75431664
171Autoimmune thrombocytopenia (HP:0001973)1.75231116
172Duplicated collecting system (HP:0000081)1.74409023
173Fair hair (HP:0002286)1.73507498
174Spontaneous abortion (HP:0005268)1.73177184
175Sloping forehead (HP:0000340)1.70834647
176Cystic hygroma (HP:0000476)1.70805721
177Abnormality of the hepatic vasculature (HP:0006707)1.70475758
178Abnormality of the columella (HP:0009929)1.69452514
179Spondylolisthesis (HP:0003302)1.69386135
180Abnormality of the duodenum (HP:0002246)1.68874269
181Embryonal renal neoplasm (HP:0011794)1.68156022
182Volvulus (HP:0002580)1.66875100
183Hypergonadotropic hypogonadism (HP:0000815)1.63751989
184Depressed nasal tip (HP:0000437)1.62272094
185Anal atresia (HP:0002023)1.61285827
186Chorioretinal coloboma (HP:0000567)1.61184197
187Nonprogressive disorder (HP:0003680)1.61087008
188Primary amenorrhea (HP:0000786)1.60360953
189Abnormal respiratory motile cilium physiology (HP:0012261)1.60329557
190Hyperglycemia (HP:0003074)1.59865285
191Aplasia/Hypoplasia of the tongue (HP:0010295)1.59780928
192Generalized hypopigmentation of hair (HP:0011358)1.57713417
193Erectile abnormalities (HP:0100639)1.56858656
194Prominent nose (HP:0000448)1.56662534
195Bone marrow hypocellularity (HP:0005528)1.54674038

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS17.91024438
2STK38L5.46076595
3LATS25.02438654
4MAP4K13.52245755
5ERBB43.07556784
6RIPK42.75310493
7PRPF4B2.71515055
8MUSK2.65658144
9MAP3K62.63615480
10STK32.55124299
11CDC72.22945675
12PLK42.22053379
13TAOK32.21951585
14STK382.04281384
15FES2.03516676
16TYK22.00425084
17TNK21.99446976
18NUAK11.89386950
19BLK1.81680274
20FGFR41.67314863
21CAMK1D1.65803224
22CDK121.64896210
23SYK1.61562581
24SIK21.59496891
25SRPK11.51688685
26MAP3K131.51434518
27CDK81.51089879
28ZAP701.48121169
29ITK1.45191295
30ERN11.40319452
31BTK1.40238207
32CAMKK21.36921992
33CDC42BPA1.35103846
34CHEK21.34504787
35TTK1.33411376
36KIT1.30629318
37CAMKK11.25498579
38RAF11.25182000
39MAP3K71.22280942
40CSF1R1.21228830
41CAMK1G1.20854683
42MAPK131.19883639
43GRK61.17636491
44HCK1.17525763
45CSK1.15869975
46LYN1.14859263
47EPHB11.14099228
48TGFBR21.13896554
49LCK1.12118817
50TBK11.08863185
51TAOK11.06757046
52JAK31.06407272
53CDK191.06170232
54CDK91.05930786
55MELK1.04901988
56DMPK1.03911096
57UHMK11.01696386
58SGK21.01250558
59WNK11.00754007
60PRKAA21.00694021
61FGR1.00366043
62MAP3K101.00119198
63MAP3K40.98528193
64FRK0.98163527
65ABL20.97480298
66MAPK120.94392110
67MAP2K70.92220418
68CDK30.92186058
69PDK10.91730464
70MAP3K110.90158270
71PDGFRB0.86991030
72DYRK1B0.86446329
73FGFR20.86444196
74MAPK70.86183302
75KSR20.85809832
76PRKCQ0.84692742
77NEK60.83905923
78STK240.82365119
79PRKD30.80532623
80PAK60.79837904
81RIPK10.79288751
82ATM0.78016103
83IRAK30.77640149
84MAP2K30.77235921
85PLK10.76452536
86NEK20.75347344
87BRAF0.75296337
88MAP3K10.71960436
89INSRR0.71529139
90IKBKB0.71528648
91ACVR1B0.70704285
92CAMK40.70285321
93PRKAA10.68617849
94ABL10.68220265
95TXK0.67924436
96EIF2AK20.67707987
97BRD40.67704878
98MATK0.67601657
99DAPK20.64504421
100EPHA30.63325975
101ZAK0.63111553
102PRKD20.61992768
103GRK70.61953376
104NTRK20.61890230
105CHEK10.61715533
106PDPK10.61559762
107EEF2K0.60813208
108SGK30.60085785
109MAP2K60.59092711
110CHUK0.59044680
111KSR10.58718347
112RET0.58708018
113YES10.58609733
114FYN0.58289349
115DYRK20.57380543
116SIK30.56021094
117CDK60.55940968
118STK110.55838409
119AURKB0.53595804
120MAPK100.53359587
121MARK20.53337869
122MKNK20.53252740
123CAMK10.53076224
124SGK2230.50107220
125SGK4940.50107220
126MAP3K90.48329107
127ATR0.48322563
128PRKCZ0.46438457
129TRPM70.45706844
130BMPR1B0.45644345
131NEK90.45212517
132PIM10.43227115
133DYRK1A0.42282989
134TRIB30.41786089
135CDK50.41572769
136JAK10.40763495
137PLK30.40723909
138MAP3K140.40464850
139CASK0.39201364
140IKBKE0.37909608
141CDK70.37597370
142NLK0.36957924
143CDK10.36495560
144AKT30.35746331
145SGK10.35224939
146HIPK20.33681652
147FGFR30.33339258
148STK40.31874544
149AKT10.30249985
150CDK20.30122293
151MAPK140.28860274
152TYRO30.28651938
153VRK10.28458894
154MAPK110.28334500
155TEC0.27959201
156BRSK20.27889030
157CSNK1G10.25153965
158GSK3B0.25094678
159PIK3CA0.24961079
160JAK20.24752022
161TNIK0.23546161
162IRAK40.23241105
163MAP3K50.23215426

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.12360964
2Cell cycle_Homo sapiens_hsa041102.69698311
3Staphylococcus aureus infection_Homo sapiens_hsa051502.62011881
4Basal transcription factors_Homo sapiens_hsa030222.42194812
5RNA degradation_Homo sapiens_hsa030182.26228214
6Homologous recombination_Homo sapiens_hsa034402.24743179
7Circadian rhythm_Homo sapiens_hsa047102.16388377
8Sphingolipid metabolism_Homo sapiens_hsa006002.05327057
9Graft-versus-host disease_Homo sapiens_hsa053322.03663549
10Allograft rejection_Homo sapiens_hsa053302.00249496
11Osteoclast differentiation_Homo sapiens_hsa043801.93279007
12Lysine degradation_Homo sapiens_hsa003101.90812084
13Ovarian steroidogenesis_Homo sapiens_hsa049131.90715684
14Autoimmune thyroid disease_Homo sapiens_hsa053201.88484063
15Pancreatic cancer_Homo sapiens_hsa052121.86068380
16Primary immunodeficiency_Homo sapiens_hsa053401.84152237
17Vitamin B6 metabolism_Homo sapiens_hsa007501.78298320
18p53 signaling pathway_Homo sapiens_hsa041151.70571258
19Type I diabetes mellitus_Homo sapiens_hsa049401.69600207
20B cell receptor signaling pathway_Homo sapiens_hsa046621.69373253
21Asthma_Homo sapiens_hsa053101.67168906
22T cell receptor signaling pathway_Homo sapiens_hsa046601.56961481
23Non-homologous end-joining_Homo sapiens_hsa034501.54154838
24Other glycan degradation_Homo sapiens_hsa005111.53832975
25MicroRNAs in cancer_Homo sapiens_hsa052061.48920079
26Tuberculosis_Homo sapiens_hsa051521.48838388
27TGF-beta signaling pathway_Homo sapiens_hsa043501.48396794
28Prolactin signaling pathway_Homo sapiens_hsa049171.48119029
29Dorso-ventral axis formation_Homo sapiens_hsa043201.37606557
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.33786315
31Complement and coagulation cascades_Homo sapiens_hsa046101.31232636
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.25984987
33Pertussis_Homo sapiens_hsa051331.24896261
34Choline metabolism in cancer_Homo sapiens_hsa052311.24605994
35Ether lipid metabolism_Homo sapiens_hsa005651.22678384
36Acute myeloid leukemia_Homo sapiens_hsa052211.19659651
37Antigen processing and presentation_Homo sapiens_hsa046121.19344112
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.19279023
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17277378
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10629602
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.07578195
42Herpes simplex infection_Homo sapiens_hsa051681.06986157
43Carbohydrate digestion and absorption_Homo sapiens_hsa049731.05211337
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02699575
45Inositol phosphate metabolism_Homo sapiens_hsa005621.02356102
46FoxO signaling pathway_Homo sapiens_hsa040681.02071267
47Linoleic acid metabolism_Homo sapiens_hsa005911.00689845
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99952686
49Viral myocarditis_Homo sapiens_hsa054160.99262533
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.97437769
51ABC transporters_Homo sapiens_hsa020100.96059675
52Long-term potentiation_Homo sapiens_hsa047200.95544308
53Prostate cancer_Homo sapiens_hsa052150.95335390
54Colorectal cancer_Homo sapiens_hsa052100.94108589
55GnRH signaling pathway_Homo sapiens_hsa049120.91824973
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91604605
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91167732
58Small cell lung cancer_Homo sapiens_hsa052220.89432404
59mRNA surveillance pathway_Homo sapiens_hsa030150.89429000
60Endometrial cancer_Homo sapiens_hsa052130.88696009
61Oocyte meiosis_Homo sapiens_hsa041140.88691225
62Hepatitis B_Homo sapiens_hsa051610.87256215
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.87214937
64ErbB signaling pathway_Homo sapiens_hsa040120.86871016
65Rheumatoid arthritis_Homo sapiens_hsa053230.86264218
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86155029
67Lysosome_Homo sapiens_hsa041420.85552141
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85302423
69Pentose phosphate pathway_Homo sapiens_hsa000300.84590696
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84295819
71Influenza A_Homo sapiens_hsa051640.82751893
72Ras signaling pathway_Homo sapiens_hsa040140.82617714
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82147257
74TNF signaling pathway_Homo sapiens_hsa046680.81807981
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79310620
76cAMP signaling pathway_Homo sapiens_hsa040240.78741928
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.78333503
78Phagosome_Homo sapiens_hsa041450.77243417
79Renin secretion_Homo sapiens_hsa049240.76956636
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76534139
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76280672
82Regulation of autophagy_Homo sapiens_hsa041400.75879020
83African trypanosomiasis_Homo sapiens_hsa051430.75740767
84Adherens junction_Homo sapiens_hsa045200.75734562
85Chemokine signaling pathway_Homo sapiens_hsa040620.75215424
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75148004
87Renal cell carcinoma_Homo sapiens_hsa052110.73892401
88Hepatitis C_Homo sapiens_hsa051600.73799780
89Chronic myeloid leukemia_Homo sapiens_hsa052200.73554633
90VEGF signaling pathway_Homo sapiens_hsa043700.71854916
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.71768059
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71701997
93Non-small cell lung cancer_Homo sapiens_hsa052230.71555941
94RNA polymerase_Homo sapiens_hsa030200.69665956
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69542273
96Measles_Homo sapiens_hsa051620.68142074
97Insulin resistance_Homo sapiens_hsa049310.68141486
98RNA transport_Homo sapiens_hsa030130.67928960
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.66420587
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.66046831
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.64536814
102Nicotine addiction_Homo sapiens_hsa050330.64157612
103Thyroid cancer_Homo sapiens_hsa052160.64039311
104Type II diabetes mellitus_Homo sapiens_hsa049300.63662907
105Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63646839
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.61579373
107MAPK signaling pathway_Homo sapiens_hsa040100.61325934
108Histidine metabolism_Homo sapiens_hsa003400.61238276
109Renin-angiotensin system_Homo sapiens_hsa046140.60684275
110Melanoma_Homo sapiens_hsa052180.58160911
111Oxytocin signaling pathway_Homo sapiens_hsa049210.57120210
112Notch signaling pathway_Homo sapiens_hsa043300.56471861
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55341557
114Hematopoietic cell lineage_Homo sapiens_hsa046400.54966325
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.54617201
116Wnt signaling pathway_Homo sapiens_hsa043100.54539210
117Serotonergic synapse_Homo sapiens_hsa047260.54258572
118Pathways in cancer_Homo sapiens_hsa052000.52455622
119Glutamatergic synapse_Homo sapiens_hsa047240.51151642
120mTOR signaling pathway_Homo sapiens_hsa041500.50870523
121Cholinergic synapse_Homo sapiens_hsa047250.50435125
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49537310
123Taste transduction_Homo sapiens_hsa047420.48814472
124Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48178294
125Legionellosis_Homo sapiens_hsa051340.48114982
126Hippo signaling pathway_Homo sapiens_hsa043900.47392629
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47347221
128Cocaine addiction_Homo sapiens_hsa050300.47277227
129HTLV-I infection_Homo sapiens_hsa051660.47003628
130Fat digestion and absorption_Homo sapiens_hsa049750.46491423
131Basal cell carcinoma_Homo sapiens_hsa052170.46138198
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.45296469
133Salmonella infection_Homo sapiens_hsa051320.44971498
134cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44709080
135Estrogen signaling pathway_Homo sapiens_hsa049150.44638962
136Toxoplasmosis_Homo sapiens_hsa051450.44550424
137Long-term depression_Homo sapiens_hsa047300.44283127
138Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44167158
139RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43873740
140Purine metabolism_Homo sapiens_hsa002300.43645617
141Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43567831
142Vascular smooth muscle contraction_Homo sapiens_hsa042700.43498979
143Glycerolipid metabolism_Homo sapiens_hsa005610.43401772
144Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42942067
145PPAR signaling pathway_Homo sapiens_hsa033200.42320339
146Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42065359
147Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42016734
148Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41267317
149Platelet activation_Homo sapiens_hsa046110.40931646
150Leishmaniasis_Homo sapiens_hsa051400.40912301
151Arachidonic acid metabolism_Homo sapiens_hsa005900.40589036
152Malaria_Homo sapiens_hsa051440.39977000

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