KDM6A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. Multiple alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of Wnt signaling pathway involved in heart development (GO:0003307)5.51177638
2pre-miRNA processing (GO:0031054)4.52957311
3necroptotic process (GO:0070266)4.38406071
4negative regulation of cell fate specification (GO:0009996)4.24862230
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.23148551
6mitotic sister chromatid cohesion (GO:0007064)4.22936382
7positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)4.01219904
8regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)4.01219904
9intestinal epithelial cell development (GO:0060576)3.96952386
10phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.94209377
11NIK/NF-kappaB signaling (GO:0038061)3.70893740
12secondary heart field specification (GO:0003139)3.68762577
13heart field specification (GO:0003128)3.68762577
14iron ion import (GO:0097286)3.66820745
15positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.66266664
16regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.66266664
17nuclear pore complex assembly (GO:0051292)3.63152786
18positive regulation of endothelial cell apoptotic process (GO:2000353)3.62939367
19cytoplasmic mRNA processing body assembly (GO:0033962)3.48265192
20cardiac chamber formation (GO:0003207)3.43699883
21regulation of DNA damage checkpoint (GO:2000001)3.40651826
22regulation of RIG-I signaling pathway (GO:0039535)3.40465903
23necrotic cell death (GO:0070265)3.39522224
24insulin-like growth factor receptor signaling pathway (GO:0048009)3.33700972
25intra-S DNA damage checkpoint (GO:0031573)3.27326126
26positive regulation of gamma-delta T cell activation (GO:0046645)3.23121105
27programmed necrotic cell death (GO:0097300)3.21280021
28negative regulation of glycogen biosynthetic process (GO:0045719)3.18673807
29nuclear pore organization (GO:0006999)3.17824546
30negative regulation of histone methylation (GO:0031061)3.17689570
31positive regulation of mRNA 3-end processing (GO:0031442)3.17595049
32definitive hemopoiesis (GO:0060216)3.16804528
33histone H3-K4 trimethylation (GO:0080182)3.15385753
34cellular anion homeostasis (GO:0030002)3.15150667
35* histone lysine demethylation (GO:0070076)3.12320206
36cardiac ventricle formation (GO:0003211)3.10950556
37regulation of mRNA 3-end processing (GO:0031440)3.08204968
38cell migration involved in heart development (GO:0060973)3.05495236
39negative regulation of mRNA processing (GO:0050686)3.02985346
40regulation of mRNA catabolic process (GO:0061013)3.00720388
41* histone demethylation (GO:0016577)2.97049035
42replicative senescence (GO:0090399)2.96801876
43regulation of NFAT protein import into nucleus (GO:0051532)2.95732937
44positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.95446535
45regulation of histone H3-K9 methylation (GO:0051570)2.94036707
46positive regulation of fibroblast migration (GO:0010763)2.90739580
47histone H3-K9 demethylation (GO:0033169)2.89621091
48negative regulation of mRNA metabolic process (GO:1903312)2.88971998
49T cell apoptotic process (GO:0070231)2.87723732
50negative T cell selection (GO:0043383)2.87104419
51negative regulation of cell fate commitment (GO:0010454)2.86763214
52viral mRNA export from host cell nucleus (GO:0046784)2.86005220
53regulation of histone H3-K27 methylation (GO:0061085)2.84703567
54negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.84192914
55negative thymic T cell selection (GO:0045060)2.83328445
56regulation of RNA export from nucleus (GO:0046831)2.82933451
57regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.81877908
58regulation of interleukin-12 biosynthetic process (GO:0045075)2.76125250
59positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.71880880
60regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.69733037
61pore complex assembly (GO:0046931)2.67911629
62regulation of sister chromatid cohesion (GO:0007063)2.67676030
63positive regulation of mitotic sister chromatid separation (GO:1901970)2.67485737
64positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.67485737
65positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.67485737
66regulation of cell fate specification (GO:0042659)2.66027837
67* protein demethylation (GO:0006482)2.65621489
68* protein dealkylation (GO:0008214)2.65621489
69embryonic process involved in female pregnancy (GO:0060136)2.64647954
70lateral sprouting from an epithelium (GO:0060601)2.63725675
71positive regulation of interleukin-17 production (GO:0032740)2.61924073
72negative regulation of translation, ncRNA-mediated (GO:0040033)2.60141845
73regulation of translation, ncRNA-mediated (GO:0045974)2.60141845
74negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.60141845
75positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.59662530
76histone H3-K36 demethylation (GO:0070544)2.58429915
77regulation of gamma-delta T cell differentiation (GO:0045586)2.57887743
78positive regulation of natural killer cell differentiation (GO:0032825)2.56036425
79nuclear envelope organization (GO:0006998)2.55243021
80positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.54920786
81monoubiquitinated protein deubiquitination (GO:0035520)2.54820468
82DNA synthesis involved in DNA repair (GO:0000731)2.54187678
83interferon-gamma production (GO:0032609)2.53486379
84myeloid dendritic cell activation (GO:0001773)2.51804181
85negative regulation of fibroblast apoptotic process (GO:2000270)2.51588369
86meiotic chromosome segregation (GO:0045132)2.51531105
87cell migration involved in gastrulation (GO:0042074)2.49972751
88regulation of gamma-delta T cell activation (GO:0046643)2.49315978
89negative regulation of DNA repair (GO:0045738)2.48990447
90myeloid dendritic cell differentiation (GO:0043011)2.48848422
91positive regulation of mRNA processing (GO:0050685)2.48690016
92histone H3-K9 modification (GO:0061647)2.48337641
93histone H3-K9 methylation (GO:0051567)2.48045813
94phosphatidylinositol phosphorylation (GO:0046854)2.47560704
95growth hormone receptor signaling pathway (GO:0060396)2.47280981
96determination of adult lifespan (GO:0008340)2.46773017
97peptidyl-lysine trimethylation (GO:0018023)2.46397645
98regulation of alpha-beta T cell proliferation (GO:0046640)2.46023543
99response to muramyl dipeptide (GO:0032495)2.44496876
100mRNA cleavage (GO:0006379)2.44130306
101DNA replication checkpoint (GO:0000076)2.43591062
102lymphocyte apoptotic process (GO:0070227)2.43519383
103regulation of telomere maintenance via telomerase (GO:0032210)2.42980337
104spleen development (GO:0048536)2.41665191
105germinal center formation (GO:0002467)2.41588863
106negative regulation of B cell proliferation (GO:0030889)2.40073146
107hepatocyte apoptotic process (GO:0097284)2.39473621
108DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.39410431
109regulation of T cell tolerance induction (GO:0002664)2.39022421
110T-helper cell differentiation (GO:0042093)2.37057841
111CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.37057841
112histone H4-K16 acetylation (GO:0043984)2.36522423
113positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.36325357
114negative regulation of histone modification (GO:0031057)2.36131066
115positive regulation of mRNA metabolic process (GO:1903313)2.36059841
116nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.35624521
117regulation of chromatin silencing (GO:0031935)2.34672167
118negative regulation of RNA splicing (GO:0033119)2.34276475
119sister chromatid cohesion (GO:0007062)2.33934693
120replication fork processing (GO:0031297)2.33290583
121T cell selection (GO:0045058)2.31823746
122positive regulation of histone methylation (GO:0031062)2.31802195
123positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.31580680
124embryonic hemopoiesis (GO:0035162)2.31572628
125neutrophil activation (GO:0042119)2.31458677
126mitotic chromosome condensation (GO:0007076)2.30969090
127negative regulation of DNA-dependent DNA replication (GO:2000104)2.30641604
128positive regulation of defense response to virus by host (GO:0002230)2.30037761
129positive regulation of chromosome segregation (GO:0051984)2.29425634
130regulation of histone methylation (GO:0031060)2.29068678
131N-terminal protein amino acid acetylation (GO:0006474)2.28689998
132thymic T cell selection (GO:0045061)2.26749302
133* histone H3-K4 methylation (GO:0051568)2.25721901
134positive regulation of mRNA catabolic process (GO:0061014)2.25544894
135regulation of protein polyubiquitination (GO:1902914)2.25534697
136mitotic nuclear envelope disassembly (GO:0007077)2.25415802
137positive regulation of interleukin-2 production (GO:0032743)2.24700603
138maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.23902400
139histone H2A monoubiquitination (GO:0035518)2.22865091
140regulation of DNA endoreduplication (GO:0032875)2.22428926
141regulation of necroptotic process (GO:0060544)2.22277900
142regulation of mitotic spindle organization (GO:0060236)2.22210805
143positive regulation of alpha-beta T cell proliferation (GO:0046641)2.20996542
144regulation of nucleobase-containing compound transport (GO:0032239)2.20082005
145antigen processing and presentation of endogenous antigen (GO:0019883)2.19221538
146regulation of spindle organization (GO:0090224)2.18433879
147positive regulation of granulocyte differentiation (GO:0030854)2.14688222
148megakaryocyte development (GO:0035855)2.13256397
149DNA damage response, signal transduction resulting in transcription (GO:0042772)2.13033600
150natural killer cell activation (GO:0030101)2.11990370
151kinetochore organization (GO:0051383)2.10842245
152alpha-beta T cell differentiation involved in immune response (GO:0002293)2.10130476
153alpha-beta T cell activation involved in immune response (GO:0002287)2.10130476
154T cell differentiation involved in immune response (GO:0002292)2.10130476
155positive regulation of interferon-beta production (GO:0032728)2.09760483
156negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.09522613
157positive regulation of interferon-alpha production (GO:0032727)2.09448273
158cellular response to zinc ion (GO:0071294)2.07869117
159embryonic camera-type eye morphogenesis (GO:0048596)2.07830549
160neutrophil activation involved in immune response (GO:0002283)2.07550229
161cellular response to growth hormone stimulus (GO:0071378)2.07464658
162nuclear envelope disassembly (GO:0051081)2.07320507
163membrane disassembly (GO:0030397)2.07320507
164positive regulation of protein import into nucleus, translocation (GO:0033160)2.07256873
165B cell homeostasis (GO:0001782)2.06495052
166T cell activation involved in immune response (GO:0002286)2.06292227

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.52324286
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.46223319
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.44192359
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.18321730
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.13602092
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.12109479
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.11083455
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.69959056
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.64896105
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.59796633
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.52221816
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.46415129
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.37686847
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.37686847
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.37686847
16SCL_19346495_ChIP-Seq_HPC-7_Human2.27382978
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.22918632
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.17117626
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.16457875
20RUNX_20019798_ChIP-Seq_JUKART_Human2.13632093
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.12934823
22TP63_19390658_ChIP-ChIP_HaCaT_Human2.08928104
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.05073161
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.05019201
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01772732
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93798340
27* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.91844917
28IRF8_27001747_Chip-Seq_BMDM_Mouse1.86525451
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.84946192
30MYB_26560356_Chip-Seq_TH2_Human1.81219977
31CHD1_26751641_Chip-Seq_LNCaP_Human1.74223570
32MYB_26560356_Chip-Seq_TH1_Human1.73971592
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.73283464
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.72349207
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71769309
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.71234406
37GATA1_22025678_ChIP-Seq_K562_Human1.62503962
38MYC_22102868_ChIP-Seq_BL_Human1.54477818
39CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.52877802
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52639290
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.49246433
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.48348481
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.46745113
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.46694180
45* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.41923207
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.41639160
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.40490056
48* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.39794896
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.38949950
50PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35783254
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35568346
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.30492145
53TCF7_22412390_ChIP-Seq_EML_Mouse1.27701321
54AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.22792210
55SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.21423893
56SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20464959
57GATA3_27048872_Chip-Seq_THYMUS_Human1.20419928
58MAF_26560356_Chip-Seq_TH1_Human1.20032138
59RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.19623610
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19299980
61AR_21909140_ChIP-Seq_LNCAP_Human1.19111159
62FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18621501
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16811341
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16592014
65PKCTHETA_26484144_Chip-Seq_BREAST_Human1.16469881
66* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14296515
67PU_27001747_Chip-Seq_BMDM_Mouse1.13705613
68FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.13229185
69SPI1_23547873_ChIP-Seq_NB4_Human1.13099848
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.11782107
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.10736723
72* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09274433
73HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.08444187
74EWS_26573619_Chip-Seq_HEK293_Human1.07637186
75BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05043473
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04681847
77ESR1_20079471_ChIP-ChIP_T-47D_Human1.04184278
78SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.03837876
79SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.03837876
80KDM5A_27292631_Chip-Seq_BREAST_Human1.03572958
81KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03511535
82ELK1_19687146_ChIP-ChIP_HELA_Human0.99989683
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98767097
84HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98604612
85* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98231662
86UTX_26944678_Chip-Seq_JUKART_Human0.97230402
87EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97089692
88BRD4_25478319_ChIP-Seq_HGPS_Human0.96752961
89WT1_19549856_ChIP-ChIP_CCG9911_Human0.96022366
90RUNX1_22412390_ChIP-Seq_EML_Mouse0.95616235
91VDR_21846776_ChIP-Seq_THP-1_Human0.94986323
92FOXO3_23340844_ChIP-Seq_DLD1_Human0.93359719
93VDR_24787735_ChIP-Seq_THP-1_Human0.93134915
94FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93000534
95GATA2_19941826_ChIP-Seq_K562_Human0.92991830
96SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92989254
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92944580
98ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92868541
99SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91607768
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91421843
101VDR_24763502_ChIP-Seq_THP-1_Human0.90817544
102CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90807195
103VDR_22108803_ChIP-Seq_LS180_Human0.90605152
104POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89431240
105SPI1_23127762_ChIP-Seq_K562_Human0.89188694
106TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.88589365
107AR_21572438_ChIP-Seq_LNCaP_Human0.85867531
108GATA3_26560356_Chip-Seq_TH2_Human0.85852362
109FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.84926544
110FUS_26573619_Chip-Seq_HEK293_Human0.84101093
111MYCN_18555785_ChIP-Seq_MESCs_Mouse0.84045157
112PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83736606
113SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83435975
114GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83217948
115MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.83142833
116* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82792287
117P300_19829295_ChIP-Seq_ESCs_Human0.81259945
118TAF15_26573619_Chip-Seq_HEK293_Human0.81014270
119TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.80823623
120FOXM1_26456572_ChIP-Seq_MCF-7_Human0.77710047
121FLI1_27457419_Chip-Seq_LIVER_Mouse0.77235198
122TCF3_18692474_ChIP-Seq_MESCs_Mouse0.76920486
123IGF1R_20145208_ChIP-Seq_DFB_Human0.76442755
124NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.75432794
125KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.74970674
126SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.74885851
127CIITA_25753668_ChIP-Seq_RAJI_Human0.74008078
128GATA1_19941826_ChIP-Seq_K562_Human0.72971237
129TP53_16413492_ChIP-PET_HCT116_Human0.71700390
130MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.70219143
131BP1_19119308_ChIP-ChIP_Hs578T_Human0.70089643

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.61307159
2MP0001835_abnormal_antigen_presentation2.61512636
3MP0000685_abnormal_immune_system2.52629254
4MP0000569_abnormal_digit_pigmentation2.44737949
5MP0002009_preneoplasia2.31423977
6MP0008877_abnormal_DNA_methylation2.28849981
7MP0002166_altered_tumor_susceptibility2.13452373
8MP0002396_abnormal_hematopoietic_system2.12239685
9MP0005671_abnormal_response_to2.09047910
10MP0002877_abnormal_melanocyte_morpholog2.08914961
11MP0010094_abnormal_chromosome_stability2.08298064
12MP0002234_abnormal_pharynx_morphology2.05712427
13MP0003763_abnormal_thymus_physiology2.01819454
14MP0001790_abnormal_immune_system2.01610532
15MP0005387_immune_system_phenotype2.01610532
16MP0001800_abnormal_humoral_immune1.97788481
17MP0002006_tumorigenesis1.93748501
18MP0004808_abnormal_hematopoietic_stem1.90803211
19MP0001346_abnormal_lacrimal_gland1.84688926
20MP0004264_abnormal_extraembryonic_tissu1.79692681
21MP0003077_abnormal_cell_cycle1.78770255
22MP0002254_reproductive_system_inflammat1.77874891
23MP0005310_abnormal_salivary_gland1.76794662
24MP0000383_abnormal_hair_follicle1.75500668
25MP0003693_abnormal_embryo_hatching1.72944101
26MP0001730_embryonic_growth_arrest1.71332189
27MP0005076_abnormal_cell_differentiation1.70752258
28MP0005451_abnormal_body_composition1.68632448
29MP0002398_abnormal_bone_marrow1.67394910
30MP0003221_abnormal_cardiomyocyte_apopto1.66053144
31MP0003656_abnormal_erythrocyte_physiolo1.65584760
32MP0002452_abnormal_antigen_presenting1.65099385
33MP0003111_abnormal_nucleus_morphology1.62059417
34MP0010352_gastrointestinal_tract_polyps1.60748303
35MP0008007_abnormal_cellular_replicative1.59531479
36MP0002723_abnormal_immune_serum1.54959068
37MP0005397_hematopoietic_system_phenotyp1.54860069
38MP0001545_abnormal_hematopoietic_system1.54860069
39MP0002138_abnormal_hepatobiliary_system1.54077878
40MP0003787_abnormal_imprinting1.53120478
41MP0010678_abnormal_skin_adnexa1.52237785
42MP0010307_abnormal_tumor_latency1.52200294
43MP0005666_abnormal_adipose_tissue1.51381104
44MP0002420_abnormal_adaptive_immunity1.49918011
45MP0001819_abnormal_immune_cell1.49715087
46MP0001873_stomach_inflammation1.46967646
47MP0005000_abnormal_immune_tolerance1.46581138
48MP0010234_abnormal_vibrissa_follicle1.46359567
49MP0000716_abnormal_immune_system1.38443655
50MP0006054_spinal_hemorrhage1.38269347
51MP0003300_gastrointestinal_ulcer1.37966473
52MP0004185_abnormal_adipocyte_glucose1.37640511
53MP0000490_abnormal_crypts_of1.36132365
54MP0004510_myositis1.34240329
55MP0005647_abnormal_sex_gland1.33938909
56MP0000703_abnormal_thymus_morphology1.27010942
57MP0002148_abnormal_hypersensitivity_rea1.26645467
58MP0002405_respiratory_system_inflammati1.26431392
59MP0002163_abnormal_gland_morphology1.26297929
60MP0000689_abnormal_spleen_morphology1.26160898
61MP0002722_abnormal_immune_system1.24756667
62MP0004947_skin_inflammation1.23876803
63MP0003436_decreased_susceptibility_to1.22911030
64MP0001348_abnormal_lacrimal_gland1.22445571
65MP0008058_abnormal_DNA_repair1.22401954
66MP0003943_abnormal_hepatobiliary_system1.17336887
67MP0003941_abnormal_skin_development1.16547971
68MP0010155_abnormal_intestine_physiology1.15947126
69MP0009785_altered_susceptibility_to1.15778241
70MP0002429_abnormal_blood_cell1.15146212
71MP0003453_abnormal_keratinocyte_physiol1.14234220
72MP0004197_abnormal_fetal_growth/weight/1.13113445
73MP0008995_early_reproductive_senescence1.12318384
74MP0000350_abnormal_cell_proliferation1.12214360
75MP0003123_paternal_imprinting1.11881165
76MP0005025_abnormal_response_to1.11741664
77MP0004233_abnormal_muscle_weight1.11087469
78MP0009703_decreased_birth_body1.10691651
79MP0009672_abnormal_birth_weight1.08328021
80MP0002419_abnormal_innate_immunity1.08233522
81MP0008932_abnormal_embryonic_tissue1.07493852
82MP0001697_abnormal_embryo_size1.05094130
83MP0004957_abnormal_blastocyst_morpholog1.04426068
84MP0000313_abnormal_cell_death1.03920801
85MP0003448_altered_tumor_morphology1.03208951
86MP0008004_abnormal_stomach_pH1.03032372
87MP0009278_abnormal_bone_marrow1.03013842
88MP0000566_synostosis1.02346710
89MP0010630_abnormal_cardiac_muscle1.02043308
90MP0003950_abnormal_plasma_membrane1.01406747
91MP0000627_abnormal_mammary_gland0.99543172
92MP0006082_CNS_inflammation0.97212005
93MP0004381_abnormal_hair_follicle0.96365408
94MP0003646_muscle_fatigue0.96071428
95MP0003828_pulmonary_edema0.94853582
96MP0001915_intracranial_hemorrhage0.94076793
97MP0003567_abnormal_fetal_cardiomyocyte0.93494147
98MP0001851_eye_inflammation0.92768566
99MP0005174_abnormal_tail_pigmentation0.92594044
100MP0004858_abnormal_nervous_system0.91743707
101MP0002080_prenatal_lethality0.91512911
102MP0000767_abnormal_smooth_muscle0.90836299
103MP0004130_abnormal_muscle_cell0.90735721
104MP0001293_anophthalmia0.90351646
105MP0000733_abnormal_muscle_development0.89807474
106MP0003566_abnormal_cell_adhesion0.89264071
107MP0002019_abnormal_tumor_incidence0.88237149
108MP0002086_abnormal_extraembryonic_tissu0.88099826
109MP0003091_abnormal_cell_migration0.86416561
110MP0002095_abnormal_skin_pigmentation0.86228813
111MP0003890_abnormal_embryonic-extraembry0.84795000
112MP0003121_genomic_imprinting0.84611647
113MP0002277_abnormal_respiratory_mucosa0.84005492
114MP0000537_abnormal_urethra_morphology0.83957598
115MP0000858_altered_metastatic_potential0.83664183
116MP0001672_abnormal_embryogenesis/_devel0.83469746
117MP0005380_embryogenesis_phenotype0.83469746
118MP0000465_gastrointestinal_hemorrhage0.82660846
119* MP0002085_abnormal_embryonic_tissue0.82373054
120MP0003984_embryonic_growth_retardation0.82334634
121MP0000377_abnormal_hair_follicle0.81751966
122MP0003937_abnormal_limbs/digits/tail_de0.81142438
123MP0002088_abnormal_embryonic_growth/wei0.80581676
124MP0000613_abnormal_salivary_gland0.80434960
125MP0002925_abnormal_cardiovascular_devel0.80299337
126MP0002084_abnormal_developmental_patter0.78317395
127MP0003303_peritoneal_inflammation0.78049976
128MP0001845_abnormal_inflammatory_respons0.77948312
129MP0009333_abnormal_splenocyte_physiolog0.77466476
130MP0005464_abnormal_platelet_physiology0.77083790
131MP0008260_abnormal_autophagy0.69922089
132MP0001853_heart_inflammation0.69269668
133MP0002796_impaired_skin_barrier0.69103709
134MP0000266_abnormal_heart_morphology0.68738372
135MP0003724_increased_susceptibility_to0.68145772
136MP0001784_abnormal_fluid_regulation0.67766711
137MP0003718_maternal_effect0.67498278

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)4.47491331
2* Abnormality of the fingertips (HP:0001211)3.94989995
3Abnormality of the nasal septum (HP:0000419)3.66673714
4Chin dimple (HP:0010751)3.62543997
5Volvulus (HP:0002580)3.36768728
6Enlarged epiphyses (HP:0010580)3.18966203
7Retrobulbar optic neuritis (HP:0100654)2.94645285
8Optic neuritis (HP:0100653)2.94645285
9Chromsome breakage (HP:0040012)2.93311134
10Recurrent viral infections (HP:0004429)2.76128264
11Abnormality of T cell physiology (HP:0011840)2.72919864
12Nephroblastoma (Wilms tumor) (HP:0002667)2.68096958
13Abnormality of T cell number (HP:0011839)2.64410407
14Gonadotropin excess (HP:0000837)2.62266655
15Myositis (HP:0100614)2.62165975
16Acute myeloid leukemia (HP:0004808)2.61602886
17Embryonal renal neoplasm (HP:0011794)2.60244697
18Subacute progressive viral hepatitis (HP:0006572)2.55701154
19Recurrent fungal infections (HP:0002841)2.52402489
20Prostate neoplasm (HP:0100787)2.52262297
21Ectopic kidney (HP:0000086)2.52017540
22Chromosomal breakage induced by crosslinking agents (HP:0003221)2.51785622
23T lymphocytopenia (HP:0005403)2.49414842
24Premature skin wrinkling (HP:0100678)2.47883383
25Thyroiditis (HP:0100646)2.45472893
26Autoimmune thrombocytopenia (HP:0001973)2.41281330
27Right ventricular cardiomyopathy (HP:0011663)2.40599924
28Recurrent bacterial skin infections (HP:0005406)2.34065966
29Abnormality of cells of the lymphoid lineage (HP:0012140)2.33794263
30Anterior segment dysgenesis (HP:0007700)2.33662257
31Orchitis (HP:0100796)2.33461677
32Abnormal glucose tolerance (HP:0001952)2.29092566
33Abnormality of the proximal phalanges of the hand (HP:0009834)2.25833134
34Anal stenosis (HP:0002025)2.25581556
35Glucose intolerance (HP:0000833)2.24087043
36* Neonatal hypoglycemia (HP:0001998)2.21387428
37Birth length less than 3rd percentile (HP:0003561)2.20162243
38Urticaria (HP:0001025)2.18938846
39Gastrointestinal carcinoma (HP:0002672)2.17330674
40Malignant gastrointestinal tract tumors (HP:0006749)2.17330674
41Eczematoid dermatitis (HP:0000976)2.16552314
42Diastasis recti (HP:0001540)2.14986505
43Biliary tract neoplasm (HP:0100574)2.12488581
44Recurrent abscess formation (HP:0002722)2.12388713
45Mediastinal lymphadenopathy (HP:0100721)2.11692624
46Trigonocephaly (HP:0000243)2.11631630
47* Long eyelashes (HP:0000527)2.10337950
48Abnormal hair whorl (HP:0010721)2.09021586
49Curly hair (HP:0002212)2.08838396
50Germ cell neoplasia (HP:0100728)2.08602132
51Neoplasm of the tracheobronchial system (HP:0100552)2.08336319
52Hypoplasia of the iris (HP:0007676)2.06843034
53Deep philtrum (HP:0002002)2.06673337
54Neoplasm of the oral cavity (HP:0100649)2.06358563
55* Lip pit (HP:0100267)2.05900030
56Rhabdomyosarcoma (HP:0002859)2.05232230
57Abnormality of chromosome stability (HP:0003220)2.05117302
58Hepatoblastoma (HP:0002884)2.05115657
59Hypochromic microcytic anemia (HP:0004840)2.04716550
60Acute lymphatic leukemia (HP:0006721)2.03639624
61Abnormality of incisor morphology (HP:0011063)2.03406220
62Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.03120437
63Keratoconjunctivitis (HP:0001096)2.03042114
64Absent frontal sinuses (HP:0002688)2.01473543
65Eosinophilia (HP:0001880)2.00884625
66Long nose (HP:0003189)1.99769908
67Hypochromic anemia (HP:0001931)1.99144659
68Narrow palate (HP:0000189)1.98017598
69Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.96991630
70Short 4th metacarpal (HP:0010044)1.96991630
71Chronic diarrhea (HP:0002028)1.96246822
72* Abnormality of the columella (HP:0009929)1.95828843
73Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.95334745
74Abnormality of the phalanges of the 5th finger (HP:0004213)1.95192489
75Limb hypertonia (HP:0002509)1.94918066
76Neoplasm of the small intestine (HP:0100833)1.94469951
77Syringomyelia (HP:0003396)1.93997937
78Spinal cord lesions (HP:0100561)1.93997937
79Keratoconjunctivitis sicca (HP:0001097)1.92861571
80Cellulitis (HP:0100658)1.92225112
81Prominent nose (HP:0000448)1.92143833
82Multiple enchondromatosis (HP:0005701)1.91111761
83Abnormal delayed hypersensitivity skin test (HP:0002963)1.90524543
84Arterial thrombosis (HP:0004420)1.90010681
85Severe combined immunodeficiency (HP:0004430)1.89117792
86Gonadal dysgenesis (HP:0000133)1.88886784
87Acanthocytosis (HP:0001927)1.88231458
88Abnormal pancreas size (HP:0012094)1.88162511
89Abnormality of secondary sexual hair (HP:0009888)1.87990023
90Abnormality of the axillary hair (HP:0100134)1.87990023
91Amaurosis fugax (HP:0100576)1.87069253
92Cortical dysplasia (HP:0002539)1.86399471
93Abnormality of eosinophils (HP:0001879)1.85204578
94Dislocated radial head (HP:0003083)1.84834385
95Absent eyebrow (HP:0002223)1.83269608
96Pulmonary infiltrates (HP:0002113)1.83234940
97Neoplasm of the adrenal cortex (HP:0100641)1.83076028
98Hematochezia (HP:0002573)1.82728015
99Myelodysplasia (HP:0002863)1.81806993
100Dysmetric saccades (HP:0000641)1.81459767
101Aplasia/Hypoplasia of the sternum (HP:0006714)1.81420027
102Thrombocytosis (HP:0001894)1.80829656
103Uterine leiomyosarcoma (HP:0002891)1.79910018
104Leiomyosarcoma (HP:0100243)1.79910018
105Medulloblastoma (HP:0002885)1.78984243
106Macroorchidism (HP:0000053)1.78939712
107Papillary thyroid carcinoma (HP:0002895)1.78868443
108Agammaglobulinemia (HP:0004432)1.78145425
109Abnormal biliary tract morphology (HP:0012440)1.77794262
110Abnormality of the salivary glands (HP:0010286)1.77735375
111Spondylolisthesis (HP:0003302)1.76954266
112Transitional cell carcinoma of the bladder (HP:0006740)1.76816051
113Blepharitis (HP:0000498)1.76803557
114B lymphocytopenia (HP:0010976)1.75665780
115Abnormality of B cell number (HP:0010975)1.75665780
116Short middle phalanx of the 5th finger (HP:0004220)1.75318841
117Granulocytopenia (HP:0001913)1.75266746
118Osteomyelitis (HP:0002754)1.75131240
119Persistence of primary teeth (HP:0006335)1.74842286
120Deviation of the thumb (HP:0009603)1.74076280
121Combined immunodeficiency (HP:0005387)1.73752115
122Abnormality of the incisor (HP:0000676)1.72188602
123Abnormality of chromosome segregation (HP:0002916)1.71539016
124Limited elbow extension (HP:0001377)1.71325509
125Leukocytosis (HP:0001974)1.70744899
126Abnormality of the parietal bone (HP:0002696)1.70455698
127Long clavicles (HP:0000890)1.68817082
128Clitoromegaly (HP:0000057)1.68672866
129Abnormality of the hepatic vasculature (HP:0006707)1.68400971
130Periodontitis (HP:0000704)1.68357882
131Abnormality of the radial head (HP:0003995)1.68155934
132IgM deficiency (HP:0002850)1.67615494
133Bladder neoplasm (HP:0009725)1.66947285
134Bladder carcinoma (HP:0002862)1.66947285
135IgG deficiency (HP:0004315)1.66859935
136Alveolar cell carcinoma (HP:0006519)1.66823526
137Abnormality of homocysteine metabolism (HP:0010919)1.66459995
138Homocystinuria (HP:0002156)1.66459995
139Chronic mucocutaneous candidiasis (HP:0002728)1.66406198
140Recurrent cutaneous fungal infections (HP:0011370)1.66406198
141Low anterior hairline (HP:0000294)1.64568757
142Proximal placement of thumb (HP:0009623)1.64458544
143Embryonal neoplasm (HP:0002898)1.64394242
144Midline defect of the nose (HP:0004122)1.64282953
145Autoimmune hemolytic anemia (HP:0001890)1.63959471
146Chronic otitis media (HP:0000389)1.63740862
147Abnormality of the heme biosynthetic pathway (HP:0010472)1.63312564
148Broad thumb (HP:0011304)1.63297112
149Abnormality of the distal phalanx of the thumb (HP:0009617)1.63178722
150Progressive external ophthalmoplegia (HP:0000590)1.62785065
151Azoospermia (HP:0000027)1.62022621
152Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.61971389
153Short 1st metacarpal (HP:0010034)1.61971389
154Acute hepatic failure (HP:0006554)1.61939487
155Abnormal foot bone ossification (HP:0010675)1.61905904
156Abnormality of T cells (HP:0002843)1.60516365
157Overgrowth (HP:0001548)1.60412119
158Vasculitis (HP:0002633)1.59148497
159Lymphoma (HP:0002665)1.59100748
160Calf muscle hypertrophy (HP:0008981)1.58868849
161Abnormality of oral frenula (HP:0000190)1.58456378
162Osteolytic defects of the phalanges of the hand (HP:0009771)1.58230244
163Osteolytic defects of the hand bones (HP:0009699)1.58230244
164Supernumerary ribs (HP:0005815)1.57861629
165Meningitis (HP:0001287)1.57352710
166Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.57145181

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT34.22785505
2PIK3CA4.05964878
3CAMK1G3.77957585
4CDK123.01370822
5MAP3K142.64855404
6CDK192.39504567
7TAF12.34953462
8MAP4K12.24741664
9CDC72.17867317
10TXK2.12343901
11STK102.07417764
12JAK31.99988208
13PRKD31.96116092
14CHUK1.92207327
15LATS11.90079925
16IKBKB1.87694646
17STK31.86800396
18TSSK61.71295867
19RET1.70545526
20TRPM71.70515736
21TAOK31.69122187
22MAP2K31.68419648
23PKN21.65901251
24EEF2K1.65234127
25NUAK11.62080505
26TYK21.60246010
27FGFR31.57959886
28MAP3K61.56602637
29PIM11.56193304
30CDK91.55935472
31IKBKE1.55684987
32MAP3K131.51861623
33SMG11.47735644
34OXSR11.44043363
35TNK21.42783480
36JAK11.42694087
37MELK1.42126564
38IRAK41.39201366
39TEC1.38608722
40STK41.37042276
41CLK11.34168831
42CDK61.28985486
43KIT1.27737158
44FGFR21.21467011
45ATR1.19613910
46BMPR21.13767587
47NLK1.12180836
48ITK1.12115694
49EPHA31.11303494
50RPS6KB21.10052728
51EPHB11.09102739
52MAP3K101.09034493
53SRPK11.09013531
54BRD41.08666692
55STK241.08544618
56VRK11.07049280
57CHEK21.06918016
58BMPR1B1.02863403
59TTK1.01966098
60PLK41.01468580
61ATM1.00142816
62BRSK20.99897935
63TGFBR10.99499662
64RPS6KA40.96230772
65RPS6KA50.95675590
66NEK20.95225022
67CAMKK20.94199490
68MARK30.94098614
69TBK10.93688322
70CDK30.92660184
71DMPK0.91874029
72MKNK10.91667062
73BTK0.91330021
74ERBB30.91123193
75EIF2AK30.88814464
76SGK20.84663173
77INSRR0.84382509
78NEK90.84160684
79CSF1R0.84159959
80RIPK40.83183100
81GRK70.79542419
82HIPK20.79161902
83CAMK1D0.78638104
84IRAK30.78409361
85CHEK10.77615343
86OBSCN0.77247440
87TGFBR20.77221685
88ICK0.76764446
89SGK30.75730290
90ACVR1B0.74698269
91PDGFRB0.74559874
92CDK40.74420594
93DYRK30.73815192
94FER0.73356286
95STK380.73234720
96CDK80.72380748
97LCK0.71981325
98PNCK0.71902818
99MKNK20.71473448
100MAP3K20.71072644
101ZAK0.70975620
102YES10.68431982
103MAP3K80.68367268
104PRKAA20.67241901
105EIF2AK20.66985815
106IRAK10.66112933
107FLT30.64691548
108PASK0.64106103
109STK110.64079772
110HCK0.63302556
111PRKCQ0.62749636
112WEE10.62255065
113MST40.59934986
114FGFR40.59592502
115CDK70.58629700
116PKN10.58508271
117FGR0.58228381
118MAPK120.57025885
119AURKB0.56979516
120LRRK20.56850735
121CSK0.56570431
122SYK0.55560146
123MAP3K50.55469339
124TIE10.53753597
125JAK20.53512172
126DYRK1B0.52357503
127SGK2230.51110725
128SGK4940.51110725
129WNK10.50905584
130PTK60.50890790
131TLK10.50591645
132AKT10.50445579
133MTOR0.50427707
134PIK3CG0.50040217
135ZAP700.49614092
136PRPF4B0.49199251
137TESK10.49031633
138FGFR10.43227207
139STK390.43134675
140CAMK40.41771537
141GRK60.34828224
142PLK30.33990500
143MAP2K40.32041997
144SCYL20.31878611
145EGFR0.31483288
146TNIK0.31465611

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040642.17894182
2African trypanosomiasis_Homo sapiens_hsa051432.03702806
3Primary immunodeficiency_Homo sapiens_hsa053401.96499278
4Intestinal immune network for IgA production_Homo sapiens_hsa046721.91809973
5Non-homologous end-joining_Homo sapiens_hsa034501.86379354
6Allograft rejection_Homo sapiens_hsa053301.82912032
7Cell cycle_Homo sapiens_hsa041101.80777367
8Herpes simplex infection_Homo sapiens_hsa051681.74388552
9Measles_Homo sapiens_hsa051621.69521030
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.67540237
11Leishmaniasis_Homo sapiens_hsa051401.64273636
12* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.63782615
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.57522506
14Caffeine metabolism_Homo sapiens_hsa002321.53056297
15B cell receptor signaling pathway_Homo sapiens_hsa046621.50988886
16p53 signaling pathway_Homo sapiens_hsa041151.50486638
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.49487086
18Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.48085094
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46240124
20Graft-versus-host disease_Homo sapiens_hsa053321.46199783
21Small cell lung cancer_Homo sapiens_hsa052221.45191570
22MicroRNAs in cancer_Homo sapiens_hsa052061.44482239
23Antigen processing and presentation_Homo sapiens_hsa046121.40490633
24Hematopoietic cell lineage_Homo sapiens_hsa046401.39911600
25Autoimmune thyroid disease_Homo sapiens_hsa053201.39515799
26Homologous recombination_Homo sapiens_hsa034401.38018483
27Osteoclast differentiation_Homo sapiens_hsa043801.36897941
28Fanconi anemia pathway_Homo sapiens_hsa034601.35910118
29TNF signaling pathway_Homo sapiens_hsa046681.33914363
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.32116591
31Viral carcinogenesis_Homo sapiens_hsa052031.29205255
32T cell receptor signaling pathway_Homo sapiens_hsa046601.27695708
33Hepatitis B_Homo sapiens_hsa051611.27505235
34Toxoplasmosis_Homo sapiens_hsa051451.26779333
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.24685650
36mTOR signaling pathway_Homo sapiens_hsa041501.24375375
37Pancreatic cancer_Homo sapiens_hsa052121.23124859
38Mismatch repair_Homo sapiens_hsa034301.21346002
39Apoptosis_Homo sapiens_hsa042101.21198849
40DNA replication_Homo sapiens_hsa030301.20591920
41Influenza A_Homo sapiens_hsa051641.20264165
42Vitamin digestion and absorption_Homo sapiens_hsa049771.17848027
43Vitamin B6 metabolism_Homo sapiens_hsa007501.16574275
44Viral myocarditis_Homo sapiens_hsa054161.16525458
45Notch signaling pathway_Homo sapiens_hsa043301.14851445
46Longevity regulating pathway - mammal_Homo sapiens_hsa042111.14702347
47RNA degradation_Homo sapiens_hsa030181.14564548
48Chronic myeloid leukemia_Homo sapiens_hsa052201.14411198
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14301123
50TGF-beta signaling pathway_Homo sapiens_hsa043501.12436786
51Systemic lupus erythematosus_Homo sapiens_hsa053221.10390099
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07734137
53Adherens junction_Homo sapiens_hsa045201.07283363
54Prostate cancer_Homo sapiens_hsa052151.07154414
55HTLV-I infection_Homo sapiens_hsa051661.06545817
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06360917
57Base excision repair_Homo sapiens_hsa034101.06242252
58Leukocyte transendothelial migration_Homo sapiens_hsa046701.04868932
59Basal transcription factors_Homo sapiens_hsa030221.01921598
60ErbB signaling pathway_Homo sapiens_hsa040120.99215773
61Chemokine signaling pathway_Homo sapiens_hsa040620.99127144
62Malaria_Homo sapiens_hsa051440.98716318
63Insulin resistance_Homo sapiens_hsa049310.98654238
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96246547
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93733655
66Colorectal cancer_Homo sapiens_hsa052100.89429569
67FoxO signaling pathway_Homo sapiens_hsa040680.88499019
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87937182
69RNA transport_Homo sapiens_hsa030130.87879937
70Prolactin signaling pathway_Homo sapiens_hsa049170.87027906
71mRNA surveillance pathway_Homo sapiens_hsa030150.86807821
72Epstein-Barr virus infection_Homo sapiens_hsa051690.86575509
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.86030049
74Dorso-ventral axis formation_Homo sapiens_hsa043200.85828688
75Type II diabetes mellitus_Homo sapiens_hsa049300.85539333
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.85096224
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84751077
78Acute myeloid leukemia_Homo sapiens_hsa052210.84700579
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84694003
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84442258
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83971181
82Pathways in cancer_Homo sapiens_hsa052000.83522222
83VEGF signaling pathway_Homo sapiens_hsa043700.83056874
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81642902
85Platelet activation_Homo sapiens_hsa046110.80696580
86Glioma_Homo sapiens_hsa052140.79913239
87Fatty acid biosynthesis_Homo sapiens_hsa000610.79837153
88Amoebiasis_Homo sapiens_hsa051460.79752125
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.78350759
90Renin-angiotensin system_Homo sapiens_hsa046140.77849222
91Hepatitis C_Homo sapiens_hsa051600.77646987
92Legionellosis_Homo sapiens_hsa051340.76097100
93Spliceosome_Homo sapiens_hsa030400.72850677
94Proteoglycans in cancer_Homo sapiens_hsa052050.72141663
95Shigellosis_Homo sapiens_hsa051310.72069994
96Asthma_Homo sapiens_hsa053100.71037207
97Non-small cell lung cancer_Homo sapiens_hsa052230.69359390
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68576305
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67680026
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66880088
101Choline metabolism in cancer_Homo sapiens_hsa052310.66671008
102Tuberculosis_Homo sapiens_hsa051520.66648510
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64677210
104Endometrial cancer_Homo sapiens_hsa052130.64641186
105HIF-1 signaling pathway_Homo sapiens_hsa040660.64139247
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63471608
107MAPK signaling pathway_Homo sapiens_hsa040100.63385710
108Renal cell carcinoma_Homo sapiens_hsa052110.62815337
109Insulin signaling pathway_Homo sapiens_hsa049100.62778634
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61941949
111One carbon pool by folate_Homo sapiens_hsa006700.61506946
112Thyroid cancer_Homo sapiens_hsa052160.59725677
113Lysine degradation_Homo sapiens_hsa003100.59676728
114Circadian rhythm_Homo sapiens_hsa047100.59392252
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59304560
116Inositol phosphate metabolism_Homo sapiens_hsa005620.59013666
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.58998865
118Nucleotide excision repair_Homo sapiens_hsa034200.58789253
119Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57593083
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57369403
121Hippo signaling pathway_Homo sapiens_hsa043900.56027390
122Basal cell carcinoma_Homo sapiens_hsa052170.55022022
123Ovarian steroidogenesis_Homo sapiens_hsa049130.53748422
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53539454
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52552467
126Type I diabetes mellitus_Homo sapiens_hsa049400.52491984
127Focal adhesion_Homo sapiens_hsa045100.52341024
128Melanoma_Homo sapiens_hsa052180.51754612
129Ether lipid metabolism_Homo sapiens_hsa005650.51682226
130AMPK signaling pathway_Homo sapiens_hsa041520.51350466

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