

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.26297804 |
| 2 | detection of molecule of bacterial origin (GO:0032490) | 4.55853058 |
| 3 | detection of other organism (GO:0098543) | 4.27471344 |
| 4 | detection of external biotic stimulus (GO:0098581) | 3.98753770 |
| 5 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 3.95114659 |
| 6 | negative regulation of cell killing (GO:0031342) | 3.95114659 |
| 7 | negative regulation of interleukin-12 production (GO:0032695) | 3.89101778 |
| 8 | detection of bacterium (GO:0016045) | 3.82606183 |
| 9 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 3.82440892 |
| 10 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 3.82440892 |
| 11 | modulation by symbiont of host immune response (GO:0052553) | 3.82440892 |
| 12 | positive regulation by symbiont of host defense response (GO:0052509) | 3.82440892 |
| 13 | modulation by symbiont of host defense response (GO:0052031) | 3.82440892 |
| 14 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 3.82440892 |
| 15 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 3.54776737 |
| 16 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.52221608 |
| 17 | detection of biotic stimulus (GO:0009595) | 3.49087434 |
| 18 | negative regulation of T cell mediated immunity (GO:0002710) | 3.46837162 |
| 19 | cytoplasmic mRNA processing body assembly (GO:0033962) | 3.38764875 |
| 20 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.36626928 |
| 21 | positive regulation of gamma-delta T cell activation (GO:0046645) | 3.30372249 |
| 22 | positive regulation of cellular amide metabolic process (GO:0034250) | 3.30147508 |
| 23 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 3.19868276 |
| 24 | macrophage activation involved in immune response (GO:0002281) | 3.17633741 |
| 25 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.17120360 |
| 26 | microglial cell activation (GO:0001774) | 3.11285898 |
| 27 | response to peptidoglycan (GO:0032494) | 3.11008012 |
| 28 | regulation of tolerance induction (GO:0002643) | 3.09535833 |
| 29 | production of molecular mediator involved in inflammatory response (GO:0002532) | 3.05839231 |
| 30 | negative regulation of erythrocyte differentiation (GO:0045647) | 3.05738337 |
| 31 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.04685901 |
| 32 | regulation of T cell tolerance induction (GO:0002664) | 3.00779785 |
| 33 | granulocyte activation (GO:0036230) | 2.99942550 |
| 34 | cellular extravasation (GO:0045123) | 2.99710832 |
| 35 | neutrophil activation (GO:0042119) | 2.95202482 |
| 36 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 2.94854401 |
| 37 | leukocyte aggregation (GO:0070486) | 2.94315054 |
| 38 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 2.90593773 |
| 39 | positive regulation of tolerance induction (GO:0002645) | 2.88437324 |
| 40 | positive regulation of tumor necrosis factor biosynthetic process (GO:0042535) | 2.88066032 |
| 41 | negative regulation of leukocyte mediated immunity (GO:0002704) | 2.88043679 |
| 42 | regulation of regulatory T cell differentiation (GO:0045589) | 2.86281476 |
| 43 | activated T cell proliferation (GO:0050798) | 2.85957594 |
| 44 | myeloid leukocyte mediated immunity (GO:0002444) | 2.85118786 |
| 45 | regulation of interferon-beta biosynthetic process (GO:0045357) | 2.84164051 |
| 46 | neutrophil activation involved in immune response (GO:0002283) | 2.83517245 |
| 47 | T-helper 1 type immune response (GO:0042088) | 2.81433611 |
| 48 | defense response to protozoan (GO:0042832) | 2.81365233 |
| 49 | cellular response to ethanol (GO:0071361) | 2.77515709 |
| 50 | regulation of nitric-oxide synthase biosynthetic process (GO:0051769) | 2.76226476 |
| 51 | growth hormone receptor signaling pathway (GO:0060396) | 2.76184905 |
| 52 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 2.70391768 |
| 53 | response to host immune response (GO:0052572) | 2.70391768 |
| 54 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 2.70242546 |
| 55 | negative regulation of T-helper cell differentiation (GO:0045623) | 2.70242546 |
| 56 | regulation of necroptotic process (GO:0060544) | 2.65665260 |
| 57 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 2.65590806 |
| 58 | negative regulation of adaptive immune response based on somatic recombination of immune receptors b | 2.65302188 |
| 59 | interferon-gamma production (GO:0032609) | 2.65248806 |
| 60 | type I interferon signaling pathway (GO:0060337) | 2.65036016 |
| 61 | cellular response to type I interferon (GO:0071357) | 2.65036016 |
| 62 | response to type I interferon (GO:0034340) | 2.63756820 |
| 63 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 2.62136568 |
| 64 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 2.61187048 |
| 65 | positive regulation of granulocyte differentiation (GO:0030854) | 2.61062604 |
| 66 | response to muramyl dipeptide (GO:0032495) | 2.59938113 |
| 67 | negative regulation of adaptive immune response (GO:0002820) | 2.59889974 |
| 68 | response to host (GO:0075136) | 2.57035823 |
| 69 | response to host defenses (GO:0052200) | 2.57035823 |
| 70 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 2.57035823 |
| 71 | positive thymic T cell selection (GO:0045059) | 2.56195364 |
| 72 | response to protozoan (GO:0001562) | 2.56132909 |
| 73 | regulation of interleukin-8 biosynthetic process (GO:0045414) | 2.55748784 |
| 74 | leukocyte migration involved in inflammatory response (GO:0002523) | 2.55358723 |
| 75 | regulation of germinal center formation (GO:0002634) | 2.54149877 |
| 76 | JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397) | 2.50799301 |
| 77 | regulation of gamma-delta T cell activation (GO:0046643) | 2.48295639 |
| 78 | macrophage activation (GO:0042116) | 2.46166095 |
| 79 | immunoglobulin mediated immune response (GO:0016064) | 2.45644318 |
| 80 | respiratory burst (GO:0045730) | 2.43442552 |
| 81 | regulation of B cell differentiation (GO:0045577) | 2.42695490 |
| 82 | myeloid cell activation involved in immune response (GO:0002275) | 2.40535600 |
| 83 | positive T cell selection (GO:0043368) | 2.40521596 |
| 84 | I-kappaB phosphorylation (GO:0007252) | 2.39233788 |
| 85 | germinal center formation (GO:0002467) | 2.38870418 |
| 86 | interferon-gamma-mediated signaling pathway (GO:0060333) | 2.38483801 |
| 87 | histone H3-K4 trimethylation (GO:0080182) | 2.36724064 |
| 88 | cellular response to growth hormone stimulus (GO:0071378) | 2.33471263 |
| 89 | monoubiquitinated protein deubiquitination (GO:0035520) | 2.33239800 |
| 90 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 2.33157264 |
| 91 | negative regulation of translation involved in gene silencing by miRNA (GO:0035278) | 2.32043885 |
| 92 | negative regulation of translation, ncRNA-mediated (GO:0040033) | 2.32043885 |
| 93 | regulation of translation, ncRNA-mediated (GO:0045974) | 2.32043885 |
| 94 | B cell receptor signaling pathway (GO:0050853) | 2.31746976 |
| 95 | positive regulation of interferon-alpha production (GO:0032727) | 2.31552164 |
| 96 | neutrophil mediated immunity (GO:0002446) | 2.31384821 |
| 97 | regulation of gamma-delta T cell differentiation (GO:0045586) | 2.31266489 |
| 98 | neutrophil chemotaxis (GO:0030593) | 2.29912337 |
| 99 | regulation of alpha-beta T cell proliferation (GO:0046640) | 2.28947870 |
| 100 | regulation of clathrin-mediated endocytosis (GO:2000369) | 2.27194983 |
| 101 | regulation of protein polyubiquitination (GO:1902914) | 2.26830618 |
| 102 | regulation of interferon-alpha production (GO:0032647) | 2.26629606 |
| 103 | protein targeting to Golgi (GO:0000042) | 2.25877481 |
| 104 | cellular response to interleukin-15 (GO:0071350) | 2.24863538 |
| 105 | regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition | 2.21726647 |
| 106 | neutrophil migration (GO:1990266) | 2.21175321 |
| 107 | negative regulation of granulocyte differentiation (GO:0030853) | 2.20681210 |
| 108 | retrograde transport, vesicle recycling within Golgi (GO:0000301) | 2.20401302 |
| 109 | positive regulation of mast cell activation (GO:0033005) | 2.20145885 |
| 110 | regulation of leukocyte degranulation (GO:0043300) | 2.18944940 |
| 111 | phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092) | 2.18495159 |
| 112 | establishment of protein localization to Golgi (GO:0072600) | 2.18296428 |
| 113 | regulation of myeloid leukocyte mediated immunity (GO:0002886) | 2.17841763 |
| 114 | regulation of establishment of cell polarity (GO:2000114) | 2.17500588 |
| 115 | T-helper cell differentiation (GO:0042093) | 2.16918735 |
| 116 | CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294) | 2.16918735 |
| 117 | response to interleukin-15 (GO:0070672) | 2.16401836 |
| 118 | regulation of mast cell degranulation (GO:0043304) | 2.15363343 |
| 119 | regulation of beta-amyloid formation (GO:1902003) | 2.13866216 |
| 120 | T cell selection (GO:0045058) | 2.12975534 |
| 121 | regulation of ARF protein signal transduction (GO:0032012) | 2.12384187 |
| 122 | T cell migration (GO:0072678) | 2.08967558 |
| 123 | positive regulation of mast cell degranulation (GO:0043306) | 2.08816731 |
| 124 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 2.08816731 |
| 125 | positive regulation of macrophage cytokine production (GO:0060907) | 2.08765813 |
| 126 | positive regulation of interleukin-2 production (GO:0032743) | 2.08238398 |
| 127 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 2.07196570 |
| 128 | positive regulation of cholesterol efflux (GO:0010875) | 2.05565961 |
| 129 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 2.05264990 |
| 130 | B cell homeostasis (GO:0001782) | 2.05094302 |
| 131 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 2.04786215 |
| 132 | negative thymic T cell selection (GO:0045060) | 2.04511918 |
| 133 | granulocyte chemotaxis (GO:0071621) | 2.04438667 |
| 134 | negative regulation of alpha-beta T cell activation (GO:0046636) | 2.03387623 |
| 135 | regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151) | 2.03164283 |
| 136 | positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO | 2.03164283 |
| 137 | regulation of mast cell activation involved in immune response (GO:0033006) | 2.03036901 |
| 138 | regulation of T-helper 2 cell differentiation (GO:0045628) | 2.02698039 |
| 139 | antigen processing and presentation of endogenous antigen (GO:0019883) | 2.02364246 |
| 140 | positive regulation of B cell differentiation (GO:0045579) | 2.01957195 |
| 141 | tolerance induction (GO:0002507) | 2.01946199 |
| 142 | negative T cell selection (GO:0043383) | 2.01671521 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 3.50842621 |
| 2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 3.06844761 |
| 3 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 2.86408058 |
| 4 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.70404950 |
| 5 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 2.60523078 |
| 6 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.47457677 |
| 7 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.36721243 |
| 8 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.34980975 |
| 9 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.32758171 |
| 10 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 2.25300175 |
| 11 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.12872709 |
| 12 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.98566662 |
| 13 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.96673377 |
| 14 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.90266129 |
| 15 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.89474746 |
| 16 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.87339562 |
| 17 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.86474416 |
| 18 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.81631871 |
| 19 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.65394917 |
| 20 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.61611572 |
| 21 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.59886125 |
| 22 | TP53_16413492_ChIP-PET_HCT116_Human | 1.58279406 |
| 23 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.58023714 |
| 24 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.55564386 |
| 25 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.52664890 |
| 26 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.43621579 |
| 27 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.43548278 |
| 28 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.43199797 |
| 29 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.42119447 |
| 30 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.41341321 |
| 31 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.38753746 |
| 32 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.38659790 |
| 33 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.37151964 |
| 34 | GATA1_22025678_ChIP-Seq_K562_Human | 1.36836953 |
| 35 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.36197650 |
| 36 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.35647754 |
| 37 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.34597072 |
| 38 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.32798556 |
| 39 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.28357658 |
| 40 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.28172735 |
| 41 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.27598991 |
| 42 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.27162185 |
| 43 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.26068303 |
| 44 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.21533483 |
| 45 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.19432245 |
| 46 | UTX_26944678_Chip-Seq_JUKART_Human | 1.19094162 |
| 47 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.15857447 |
| 48 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.15802244 |
| 49 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.15739547 |
| 50 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.14636648 |
| 51 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.11858979 |
| 52 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.11108846 |
| 53 | STAT3_23295773_ChIP-Seq_U87_Human | 1.09690804 |
| 54 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.09685197 |
| 55 | GATA1_19941826_ChIP-Seq_K562_Human | 1.09454719 |
| 56 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.08893465 |
| 57 | RXR_22108803_ChIP-Seq_LS180_Human | 1.08237859 |
| 58 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.08141200 |
| 59 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.07787122 |
| 60 | GATA3_26560356_Chip-Seq_TH2_Human | 1.07082042 |
| 61 | MYB_26560356_Chip-Seq_TH2_Human | 1.05182264 |
| 62 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.05132960 |
| 63 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.05105368 |
| 64 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.04886355 |
| 65 | SPI1_23127762_ChIP-Seq_K562_Human | 1.04667846 |
| 66 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.04355967 |
| 67 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.04281932 |
| 68 | GATA2_19941826_ChIP-Seq_K562_Human | 1.04046561 |
| 69 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.03689261 |
| 70 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.03334026 |
| 71 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.02557821 |
| 72 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 1.02300358 |
| 73 | MYC_22102868_ChIP-Seq_BL_Human | 1.01658837 |
| 74 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.01140317 |
| 75 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.00985516 |
| 76 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 1.00521120 |
| 77 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.00401412 |
| 78 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 0.99854579 |
| 79 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.99392507 |
| 80 | GATA3_27048872_Chip-Seq_THYMUS_Human | 0.99387670 |
| 81 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 0.97055889 |
| 82 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 0.96910458 |
| 83 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.95986456 |
| 84 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 0.95962672 |
| 85 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.95318224 |
| 86 | MYB_26560356_Chip-Seq_TH1_Human | 0.95164392 |
| 87 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.94688818 |
| 88 | P300_19829295_ChIP-Seq_ESCs_Human | 0.94672826 |
| 89 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.93436071 |
| 90 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.93200055 |
| 91 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.92611690 |
| 92 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.92516189 |
| 93 | TCF4_23295773_ChIP-Seq_U87_Human | 0.92451643 |
| 94 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.92439412 |
| 95 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.92439412 |
| 96 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.92271079 |
| 97 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.91868880 |
| 98 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.91781514 |
| 99 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.91723949 |
| 100 | KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse | 0.91516165 |
| 101 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 0.90972845 |
| 102 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.90758760 |
| 103 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 0.90652420 |
| 104 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 0.90396643 |
| 105 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 0.90177789 |
| 106 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 0.90089119 |
| 107 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.89840769 |
| 108 | AR_25329375_ChIP-Seq_VCAP_Human | 0.89645424 |
| 109 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 0.88951068 |
| 110 | DROSHA_22980978_ChIP-Seq_HELA_Human | 0.88709417 |
| 111 | SMRT_27268052_Chip-Seq_Bcells_Human | 0.88496957 |
| 112 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.88398586 |
| 113 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.88389507 |
| 114 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.87846339 |
| 115 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.87556572 |
| 116 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.87309882 |
| 117 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.87167923 |
| 118 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.86178217 |
| 119 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.85406795 |
| 120 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 0.85376524 |
| 121 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 0.85373117 |
| 122 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.84664458 |
| 123 | MAF_26560356_Chip-Seq_TH2_Human | 0.84257467 |
| 124 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.83546398 |
| 125 | CJUN_26792858_Chip-Seq_BT549_Human | 0.82960114 |
| 126 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.82762457 |
| 127 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 0.82550245 |
| 128 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.82389318 |
| 129 | TP63_23658742_ChIP-Seq_EP156T_Human | 0.82067929 |
| 130 | TP53_18474530_ChIP-ChIP_U2OS_Human | 0.81864147 |
| 131 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 0.81606474 |
| 132 | MAF_26560356_Chip-Seq_TH1_Human | 0.81312331 |
| 133 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.81240311 |
| 134 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.77913933 |
| 135 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.76362728 |
| 136 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.76150999 |
| 137 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.73120086 |
| 138 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 0.72918673 |
| 139 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.72842638 |
| 140 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.72842638 |
| 141 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.72842638 |
| 142 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.72621983 |
| 143 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.72418255 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0000569_abnormal_digit_pigmentation | 4.09461151 |
| 2 | MP0003303_peritoneal_inflammation | 3.65780910 |
| 3 | MP0001835_abnormal_antigen_presentation | 3.38959071 |
| 4 | MP0003436_decreased_susceptibility_to | 2.93422481 |
| 5 | MP0003300_gastrointestinal_ulcer | 2.64810606 |
| 6 | MP0001790_abnormal_immune_system | 2.60975386 |
| 7 | MP0005387_immune_system_phenotype | 2.60975386 |
| 8 | MP0004510_myositis | 2.60269241 |
| 9 | MP0005000_abnormal_immune_tolerance | 2.56802288 |
| 10 | MP0005671_abnormal_response_to | 2.55108534 |
| 11 | MP0008260_abnormal_autophagy | 2.45599500 |
| 12 | MP0010234_abnormal_vibrissa_follicle | 2.45418396 |
| 13 | MP0002419_abnormal_innate_immunity | 2.44013296 |
| 14 | MP0002006_tumorigenesis | 2.38884153 |
| 15 | MP0001800_abnormal_humoral_immune | 2.37773313 |
| 16 | MP0002009_preneoplasia | 2.33572825 |
| 17 | MP0005310_abnormal_salivary_gland | 2.31274914 |
| 18 | MP0002452_abnormal_antigen_presenting | 2.28013327 |
| 19 | MP0003045_fibrosis | 2.25827189 |
| 20 | MP0002166_altered_tumor_susceptibility | 2.25560275 |
| 21 | MP0002723_abnormal_immune_serum | 2.12452328 |
| 22 | MP0002148_abnormal_hypersensitivity_rea | 2.12396904 |
| 23 | MP0001819_abnormal_immune_cell | 2.04364121 |
| 24 | MP0002420_abnormal_adaptive_immunity | 2.03570001 |
| 25 | MP0009785_altered_susceptibility_to | 2.02726397 |
| 26 | MP0000685_abnormal_immune_system | 2.02605812 |
| 27 | MP0004947_skin_inflammation | 1.91324227 |
| 28 | MP0009278_abnormal_bone_marrow | 1.90813527 |
| 29 | MP0005025_abnormal_response_to | 1.88991039 |
| 30 | MP0003183_abnormal_peptide_metabolism | 1.88635550 |
| 31 | MP0005076_abnormal_cell_differentiation | 1.79224391 |
| 32 | MP0001851_eye_inflammation | 1.78143706 |
| 33 | MP0003724_increased_susceptibility_to | 1.75041419 |
| 34 | MP0003787_abnormal_imprinting | 1.71930733 |
| 35 | MP0002405_respiratory_system_inflammati | 1.65446721 |
| 36 | MP0004381_abnormal_hair_follicle | 1.63310595 |
| 37 | MP0004883_abnormal_blood_vessel | 1.59973098 |
| 38 | MP0001533_abnormal_skeleton_physiology | 1.55628316 |
| 39 | MP0008004_abnormal_stomach_pH | 1.55142845 |
| 40 | MP0006082_CNS_inflammation | 1.53525917 |
| 41 | MP0001545_abnormal_hematopoietic_system | 1.51845735 |
| 42 | MP0005397_hematopoietic_system_phenotyp | 1.51845735 |
| 43 | MP0005464_abnormal_platelet_physiology | 1.50658554 |
| 44 | MP0008995_early_reproductive_senescence | 1.45861345 |
| 45 | MP0002398_abnormal_bone_marrow | 1.44753771 |
| 46 | MP0010155_abnormal_intestine_physiology | 1.44412412 |
| 47 | MP0003828_pulmonary_edema | 1.43917495 |
| 48 | MP0002254_reproductive_system_inflammat | 1.41844086 |
| 49 | MP0000716_abnormal_immune_system | 1.40623548 |
| 50 | MP0003763_abnormal_thymus_physiology | 1.37403637 |
| 51 | MP0009333_abnormal_splenocyte_physiolog | 1.36350526 |
| 52 | MP0004185_abnormal_adipocyte_glucose | 1.36317740 |
| 53 | MP0001845_abnormal_inflammatory_respons | 1.34137018 |
| 54 | MP0001853_heart_inflammation | 1.33678106 |
| 55 | MP0002277_abnormal_respiratory_mucosa | 1.32620531 |
| 56 | MP0008877_abnormal_DNA_methylation | 1.30888131 |
| 57 | MP0008961_abnormal_basal_metabolism | 1.30320126 |
| 58 | MP0000858_altered_metastatic_potential | 1.30293585 |
| 59 | MP0010307_abnormal_tumor_latency | 1.29536598 |
| 60 | MP0003866_abnormal_defecation | 1.27884002 |
| 61 | MP0009764_decreased_sensitivity_to | 1.25381963 |
| 62 | MP0005164_abnormal_response_to | 1.25250440 |
| 63 | MP0010678_abnormal_skin_adnexa | 1.24760635 |
| 64 | MP0002998_abnormal_bone_remodeling | 1.18849007 |
| 65 | MP0005174_abnormal_tail_pigmentation | 1.17377348 |
| 66 | MP0003221_abnormal_cardiomyocyte_apopto | 1.15872365 |
| 67 | MP0003656_abnormal_erythrocyte_physiolo | 1.15069959 |
| 68 | MP0004808_abnormal_hematopoietic_stem | 1.14396213 |
| 69 | MP0003075_altered_response_to | 1.12547499 |
| 70 | MP0003448_altered_tumor_morphology | 1.12025599 |
| 71 | MP0003453_abnormal_keratinocyte_physiol | 1.10980742 |
| 72 | MP0005167_abnormal_blood-brain_barrier | 1.09530208 |
| 73 | MP0001873_stomach_inflammation | 1.08018952 |
| 74 | MP0005409_darkened_coat_color | 1.07790800 |
| 75 | MP0002332_abnormal_exercise_endurance | 1.07527408 |
| 76 | MP0002877_abnormal_melanocyte_morpholog | 1.05824048 |
| 77 | MP0002132_abnormal_respiratory_system | 1.03366159 |
| 78 | MP0005451_abnormal_body_composition | 1.03071987 |
| 79 | MP0008057_abnormal_DNA_replication | 1.02033122 |
| 80 | MP0004264_abnormal_extraembryonic_tissu | 1.00775666 |
| 81 | MP0005058_abnormal_lysosome_morphology | 0.99564332 |
| 82 | MP0002138_abnormal_hepatobiliary_system | 0.99394104 |
| 83 | MP0000383_abnormal_hair_follicle | 0.98845412 |
| 84 | MP0002429_abnormal_blood_cell | 0.98432206 |
| 85 | MP0002928_abnormal_bile_duct | 0.96019877 |
| 86 | MP0003091_abnormal_cell_migration | 0.93346414 |
| 87 | MP0000015_abnormal_ear_pigmentation | 0.93302309 |
| 88 | MP0001501_abnormal_sleep_pattern | 0.93057536 |
| 89 | MP0004484_altered_response_of | 0.92909277 |
| 90 | MP0000689_abnormal_spleen_morphology | 0.92571488 |
| 91 | MP0005166_decreased_susceptibility_to | 0.89282810 |
| 92 | MP0002722_abnormal_immune_system | 0.89036996 |
| 93 | MP0004147_increased_porphyrin_level | 0.86766317 |
| 94 | MP0000343_altered_response_to | 0.82817719 |
| 95 | MP0004859_abnormal_synaptic_plasticity | 0.82510887 |
| 96 | MP0004742_abnormal_vestibular_system | 0.81599409 |
| 97 | MP0003690_abnormal_glial_cell | 0.80416725 |
| 98 | MP0009115_abnormal_fat_cell | 0.78577313 |
| 99 | MP0000249_abnormal_blood_vessel | 0.78045191 |
| 100 | MP0000703_abnormal_thymus_morphology | 0.77463626 |
| 101 | MP0010352_gastrointestinal_tract_polyps | 0.77460289 |
| 102 | MP0002168_other_aberrant_phenotype | 0.76185299 |
| 103 | MP0003191_abnormal_cellular_cholesterol | 0.74553151 |
| 104 | MP0009763_increased_sensitivity_to | 0.73944797 |
| 105 | MP0008469_abnormal_protein_level | 0.72779866 |
| 106 | MP0001216_abnormal_epidermal_layer | 0.72081790 |
| 107 | MP0003172_abnormal_lysosome_physiology | 0.71507464 |
| 108 | MP0004130_abnormal_muscle_cell | 0.71102193 |
| 109 | MP0006054_spinal_hemorrhage | 0.70229892 |
| 110 | MP0002396_abnormal_hematopoietic_system | 0.69818979 |
| 111 | MP0000465_gastrointestinal_hemorrhage | 0.69611573 |
| 112 | MP0001663_abnormal_digestive_system | 0.68472257 |
| 113 | MP0001191_abnormal_skin_condition | 0.65589974 |
| 114 | MP0002933_joint_inflammation | 0.65382899 |
| 115 | MP0005390_skeleton_phenotype | 0.65147362 |
| 116 | MP0002796_impaired_skin_barrier | 0.63797640 |
| 117 | MP0000427_abnormal_hair_cycle | 0.63179951 |
| 118 | MP0000371_diluted_coat_color | 0.63161136 |
| 119 | MP0005666_abnormal_adipose_tissue | 0.61489574 |
| 120 | MP0009765_abnormal_xenobiotic_induced | 0.60990598 |
| 121 | MP0003646_muscle_fatigue | 0.60110215 |
| 122 | MP0000604_amyloidosis | 0.58773861 |
| 123 | MP0002971_abnormal_brown_adipose | 0.57683728 |
| 124 | MP0000767_abnormal_smooth_muscle | 0.57159899 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Eczematoid dermatitis (HP:0000976) | 4.97973394 |
| 2 | Recurrent abscess formation (HP:0002722) | 4.92986963 |
| 3 | Recurrent bacterial skin infections (HP:0005406) | 4.55119495 |
| 4 | Abnormality of the fingertips (HP:0001211) | 3.88371984 |
| 5 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 3.63349192 |
| 6 | Mediastinal lymphadenopathy (HP:0100721) | 3.58106141 |
| 7 | Recurrent gram-negative bacterial infections (HP:0005420) | 3.54269569 |
| 8 | Gingivitis (HP:0000230) | 3.26060263 |
| 9 | Prostate neoplasm (HP:0100787) | 3.23514239 |
| 10 | Optic neuritis (HP:0100653) | 3.20920836 |
| 11 | Retrobulbar optic neuritis (HP:0100654) | 3.20920836 |
| 12 | Recurrent fungal infections (HP:0002841) | 3.20685262 |
| 13 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.08937676 |
| 14 | Obstructive lung disease (HP:0006536) | 2.99891624 |
| 15 | Chronic obstructive pulmonary disease (HP:0006510) | 2.99891624 |
| 16 | Prolonged bleeding time (HP:0003010) | 2.99192718 |
| 17 | Hematochezia (HP:0002573) | 2.96104701 |
| 18 | Orchitis (HP:0100796) | 2.88994346 |
| 19 | Stomatitis (HP:0010280) | 2.88727961 |
| 20 | Recurrent skin infections (HP:0001581) | 2.84645174 |
| 21 | Myositis (HP:0100614) | 2.76794512 |
| 22 | Recurrent cutaneous fungal infections (HP:0011370) | 2.74611356 |
| 23 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.74611356 |
| 24 | Abnormality of macrophages (HP:0004311) | 2.71736927 |
| 25 | Myocardial infarction (HP:0001658) | 2.66284148 |
| 26 | Gangrene (HP:0100758) | 2.63323209 |
| 27 | Epistaxis (HP:0000421) | 2.61596286 |
| 28 | Peritonitis (HP:0002586) | 2.60205563 |
| 29 | Thick nail (HP:0001805) | 2.59316631 |
| 30 | Encephalitis (HP:0002383) | 2.56770729 |
| 31 | Absent frontal sinuses (HP:0002688) | 2.56743981 |
| 32 | Recurrent viral infections (HP:0004429) | 2.51476192 |
| 33 | Pulmonary infiltrates (HP:0002113) | 2.49497627 |
| 34 | Urticaria (HP:0001025) | 2.46934392 |
| 35 | Thyroiditis (HP:0100646) | 2.46494182 |
| 36 | Pulmonary embolism (HP:0002204) | 2.43725626 |
| 37 | Slow saccadic eye movements (HP:0000514) | 2.40967948 |
| 38 | Autoimmune thrombocytopenia (HP:0001973) | 2.39896464 |
| 39 | Vasculitis (HP:0002633) | 2.38042608 |
| 40 | Chronic diarrhea (HP:0002028) | 2.36077460 |
| 41 | Arterial tortuosity (HP:0005116) | 2.35286606 |
| 42 | Arterial thrombosis (HP:0004420) | 2.34352939 |
| 43 | Periodontitis (HP:0000704) | 2.33890882 |
| 44 | Neoplasm of the tracheobronchial system (HP:0100552) | 2.33702691 |
| 45 | Colitis (HP:0002583) | 2.31243321 |
| 46 | Meningitis (HP:0001287) | 2.31238664 |
| 47 | Cellulitis (HP:0100658) | 2.28246831 |
| 48 | Abnormality of T cells (HP:0002843) | 2.27251560 |
| 49 | Pustule (HP:0200039) | 2.24723461 |
| 50 | Gastrointestinal infarctions (HP:0005244) | 2.19040706 |
| 51 | Lip pit (HP:0100267) | 2.18727997 |
| 52 | Keratoconjunctivitis sicca (HP:0001097) | 2.18681154 |
| 53 | Amyloidosis (HP:0011034) | 2.17502045 |
| 54 | Autoimmune hemolytic anemia (HP:0001890) | 2.17486733 |
| 55 | Spontaneous hematomas (HP:0007420) | 2.15767518 |
| 56 | Poikilocytosis (HP:0004447) | 2.14208752 |
| 57 | Acute myeloid leukemia (HP:0004808) | 2.12872594 |
| 58 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.08664250 |
| 59 | Acanthocytosis (HP:0001927) | 2.08009409 |
| 60 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 2.07179793 |
| 61 | Increased IgE level (HP:0003212) | 2.06930518 |
| 62 | Anorexia (HP:0002039) | 2.06921576 |
| 63 | Recurrent sinusitis (HP:0011108) | 2.06638332 |
| 64 | Male infertility (HP:0003251) | 2.03490608 |
| 65 | Alveolar cell carcinoma (HP:0006519) | 2.02490474 |
| 66 | Transitional cell carcinoma of the bladder (HP:0006740) | 2.01396803 |
| 67 | Narrow palate (HP:0000189) | 1.99863557 |
| 68 | Inflammation of the large intestine (HP:0002037) | 1.99481422 |
| 69 | Spondylolisthesis (HP:0003302) | 1.99430969 |
| 70 | Abnormality of the peritoneum (HP:0002585) | 1.99043979 |
| 71 | Abnormality of the endocardium (HP:0004306) | 1.97584933 |
| 72 | Febrile seizures (HP:0002373) | 1.96684899 |
| 73 | Episodic fever (HP:0001954) | 1.96584240 |
| 74 | Keratoconjunctivitis (HP:0001096) | 1.95433316 |
| 75 | Progressive visual loss (HP:0000529) | 1.94515113 |
| 76 | Agammaglobulinemia (HP:0004432) | 1.94474329 |
| 77 | Viral hepatitis (HP:0006562) | 1.94363596 |
| 78 | Increased cerebral lipofuscin (HP:0011813) | 1.94192684 |
| 79 | Difficulty running (HP:0009046) | 1.93693273 |
| 80 | Disinhibition (HP:0000734) | 1.93588427 |
| 81 | Bladder carcinoma (HP:0002862) | 1.92188180 |
| 82 | Bladder neoplasm (HP:0009725) | 1.92188180 |
| 83 | Recurrent bronchitis (HP:0002837) | 1.91712473 |
| 84 | Abnormality of the frontal sinuses (HP:0002687) | 1.91712234 |
| 85 | Segmental peripheral demyelination/remyelination (HP:0003481) | 1.91581255 |
| 86 | Abnormality of the pleura (HP:0002103) | 1.90184587 |
| 87 | Macroorchidism (HP:0000053) | 1.87921016 |
| 88 | Conjunctival telangiectasia (HP:0000524) | 1.87160133 |
| 89 | Joint swelling (HP:0001386) | 1.86004388 |
| 90 | Abnormality of the nasal septum (HP:0000419) | 1.85595180 |
| 91 | T lymphocytopenia (HP:0005403) | 1.85018628 |
| 92 | Ectropion (HP:0000656) | 1.84832939 |
| 93 | Vascular tortuosity (HP:0004948) | 1.84075938 |
| 94 | Leukocytosis (HP:0001974) | 1.83548616 |
| 95 | Thrombophlebitis (HP:0004418) | 1.82696614 |
| 96 | Vertigo (HP:0002321) | 1.82170555 |
| 97 | Papillary thyroid carcinoma (HP:0002895) | 1.81880987 |
| 98 | Abnormality of T cell number (HP:0011839) | 1.81197225 |
| 99 | Hemoptysis (HP:0002105) | 1.79333582 |
| 100 | Hip dysplasia (HP:0001385) | 1.77180330 |
| 101 | Oligodactyly (hands) (HP:0001180) | 1.76843327 |
| 102 | Polycythemia (HP:0001901) | 1.76718314 |
| 103 | Aplasia/Hypoplasia of the frontal sinuses (HP:0009119) | 1.76624369 |
| 104 | Malnutrition (HP:0004395) | 1.76259799 |
| 105 | Eosinophilia (HP:0001880) | 1.76220495 |
| 106 | Fatigue (HP:0012378) | 1.74937289 |
| 107 | Abnormality of male internal genitalia (HP:0000022) | 1.74902641 |
| 108 | Microcytic anemia (HP:0001935) | 1.74196222 |
| 109 | Abnormality of the prostate (HP:0008775) | 1.73510986 |
| 110 | Granulocytopenia (HP:0001913) | 1.73085036 |
| 111 | Systemic lupus erythematosus (HP:0002725) | 1.72497411 |
| 112 | Acute hepatic failure (HP:0006554) | 1.71601598 |
| 113 | Abnormal platelet volume (HP:0011876) | 1.70884125 |
| 114 | Polyneuropathy (HP:0001271) | 1.70784620 |
| 115 | Hypochromic microcytic anemia (HP:0004840) | 1.70400526 |
| 116 | Abnormality of liposaccharide metabolism (HP:0010968) | 1.69950428 |
| 117 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 1.69950428 |
| 118 | Abnormality of glycolipid metabolism (HP:0010969) | 1.69950428 |
| 119 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 1.69883887 |
| 120 | Inappropriate behavior (HP:0000719) | 1.68525073 |
| 121 | Acne (HP:0001061) | 1.67939807 |
| 122 | Recurrent pneumonia (HP:0006532) | 1.66801125 |
| 123 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 1.65407381 |
| 124 | Interstitial pulmonary disease (HP:0006530) | 1.65115094 |
| 125 | Gastrointestinal inflammation (HP:0004386) | 1.64702179 |
| 126 | Volvulus (HP:0002580) | 1.64009158 |
| 127 | Truncal obesity (HP:0001956) | 1.62459654 |
| 128 | Osteomyelitis (HP:0002754) | 1.61993798 |
| 129 | Hyperkalemia (HP:0002153) | 1.61200982 |
| 130 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.60034709 |
| 131 | Widely spaced teeth (HP:0000687) | 1.59977271 |
| 132 | Gingival bleeding (HP:0000225) | 1.56975944 |
| 133 | Abnormality of eosinophils (HP:0001879) | 1.56758577 |
| 134 | Facial diplegia (HP:0001349) | 1.56175986 |
| 135 | Gastrointestinal stroma tumor (HP:0100723) | 1.55864259 |
| 136 | Sepsis (HP:0100806) | 1.55071401 |
| 137 | Limited elbow extension (HP:0001377) | 1.54410583 |
| 138 | Glomerulonephritis (HP:0000099) | 1.54161380 |
| 139 | Chest pain (HP:0100749) | 1.53609662 |
| 140 | Subacute progressive viral hepatitis (HP:0006572) | 1.53332832 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TAOK3 | 3.84065912 |
| 2 | RIPK4 | 3.76092204 |
| 3 | MAP3K14 | 2.57374928 |
| 4 | LATS1 | 2.41316458 |
| 5 | FRK | 2.17237582 |
| 6 | CDK12 | 2.11007291 |
| 7 | MAP4K1 | 2.00542400 |
| 8 | MAP3K13 | 1.95697331 |
| 9 | JAK1 | 1.93802651 |
| 10 | TXK | 1.84955800 |
| 11 | TYK2 | 1.82366766 |
| 12 | FGFR3 | 1.81239699 |
| 13 | CAMK1D | 1.78680200 |
| 14 | JAK3 | 1.78213381 |
| 15 | ZAP70 | 1.67178349 |
| 16 | CAMK1G | 1.65608962 |
| 17 | NUAK1 | 1.60037290 |
| 18 | BLK | 1.46948451 |
| 19 | IKBKE | 1.46193538 |
| 20 | MAP3K2 | 1.42871389 |
| 21 | IRAK4 | 1.41665508 |
| 22 | CDK9 | 1.39431684 |
| 23 | EPHB1 | 1.39363265 |
| 24 | STK3 | 1.37178357 |
| 25 | IRAK3 | 1.32212095 |
| 26 | TAOK1 | 1.32150754 |
| 27 | TEC | 1.28119361 |
| 28 | SGK2 | 1.20393726 |
| 29 | INSRR | 1.19164064 |
| 30 | EPHA3 | 1.17425741 |
| 31 | MARK2 | 1.16683419 |
| 32 | CHUK | 1.15590925 |
| 33 | IKBKB | 1.15485794 |
| 34 | SGK3 | 1.14629071 |
| 35 | ITK | 1.13705690 |
| 36 | HCK | 1.12446759 |
| 37 | TGFBR2 | 1.09784920 |
| 38 | DMPK | 1.09661203 |
| 39 | IRAK2 | 1.08875579 |
| 40 | MAP3K6 | 1.06775478 |
| 41 | MATK | 1.06740233 |
| 42 | FGR | 1.05488209 |
| 43 | MARK3 | 1.05382730 |
| 44 | CSK | 1.05226215 |
| 45 | JAK2 | 1.03176876 |
| 46 | ERN1 | 1.02438577 |
| 47 | MAP3K9 | 1.01975369 |
| 48 | PDGFRB | 1.01480673 |
| 49 | TRPM7 | 1.00798506 |
| 50 | BMPR2 | 1.00145470 |
| 51 | PIK3CG | 0.99542606 |
| 52 | FES | 0.98411267 |
| 53 | STK10 | 0.95995964 |
| 54 | MAP3K10 | 0.93182494 |
| 55 | FGFR2 | 0.91695634 |
| 56 | TBK1 | 0.90151322 |
| 57 | PRKAA2 | 0.88856818 |
| 58 | RIPK1 | 0.88608216 |
| 59 | CAMKK2 | 0.88336769 |
| 60 | KSR1 | 0.87513643 |
| 61 | CDC42BPA | 0.86425838 |
| 62 | MAP3K7 | 0.84818264 |
| 63 | STK11 | 0.84781969 |
| 64 | KSR2 | 0.83719161 |
| 65 | GRK7 | 0.82115219 |
| 66 | BRD4 | 0.81948676 |
| 67 | SGK1 | 0.81368403 |
| 68 | MAP3K4 | 0.79609169 |
| 69 | LCK | 0.79362385 |
| 70 | SYK | 0.78995794 |
| 71 | CDK3 | 0.78814348 |
| 72 | TNK2 | 0.77226733 |
| 73 | WNK1 | 0.76047706 |
| 74 | STK38 | 0.75296778 |
| 75 | AKT3 | 0.75192338 |
| 76 | DYRK1B | 0.73628140 |
| 77 | ACVR1B | 0.72406996 |
| 78 | NLK | 0.71058529 |
| 79 | PRKCQ | 0.70381910 |
| 80 | MELK | 0.70376694 |
| 81 | ABL1 | 0.68922726 |
| 82 | PDK1 | 0.68854096 |
| 83 | CSF1R | 0.68640276 |
| 84 | BTK | 0.66311653 |
| 85 | PIM1 | 0.65150444 |
| 86 | STK4 | 0.63784738 |
| 87 | CLK1 | 0.63195144 |
| 88 | TAOK2 | 0.62818919 |
| 89 | RET | 0.62406880 |
| 90 | SIK3 | 0.62352114 |
| 91 | STK24 | 0.62327932 |
| 92 | ERBB2 | 0.61239928 |
| 93 | OBSCN | 0.61103552 |
| 94 | HIPK2 | 0.60350908 |
| 95 | FGFR4 | 0.60204825 |
| 96 | SGK494 | 0.60115914 |
| 97 | SGK223 | 0.60115914 |
| 98 | MAP3K1 | 0.59343739 |
| 99 | YES1 | 0.59181348 |
| 100 | CAMK4 | 0.58949747 |
| 101 | MAPK7 | 0.58900360 |
| 102 | PRKCH | 0.57029813 |
| 103 | SIK2 | 0.56911703 |
| 104 | LYN | 0.56594366 |
| 105 | GRK6 | 0.56267248 |
| 106 | PRKD2 | 0.54132271 |
| 107 | LRRK2 | 0.53429669 |
| 108 | PRPF4B | 0.53309230 |
| 109 | MAPK12 | 0.53133197 |
| 110 | IRAK1 | 0.52864391 |
| 111 | PDPK1 | 0.50840726 |
| 112 | NTRK3 | 0.50167160 |
| 113 | EPHA4 | 0.49642967 |
| 114 | KIT | 0.49610011 |
| 115 | CDK6 | 0.49218404 |
| 116 | MAP3K11 | 0.49133615 |
| 117 | RAF1 | 0.48612300 |
| 118 | NEK6 | 0.47536667 |
| 119 | FYN | 0.47502899 |
| 120 | PRKAA1 | 0.47454267 |
| 121 | MAP2K7 | 0.46792669 |
| 122 | MAP2K4 | 0.46437633 |
| 123 | PTK6 | 0.45347818 |
| 124 | CAMKK1 | 0.45214134 |
| 125 | MAP2K3 | 0.44231396 |
| 126 | MAP3K5 | 0.43271638 |
| 127 | TYRO3 | 0.43229255 |
| 128 | MAP3K3 | 0.41587887 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 2.12170768 |
| 2 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.03378005 |
| 3 | Leishmaniasis_Homo sapiens_hsa05140 | 2.00461547 |
| 4 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.71919793 |
| 5 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.64460988 |
| 6 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.61920080 |
| 7 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.59521470 |
| 8 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.45888989 |
| 9 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.45398985 |
| 10 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.43977618 |
| 11 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.40905952 |
| 12 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.39646349 |
| 13 | Tuberculosis_Homo sapiens_hsa05152 | 1.39300452 |
| 14 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.35705775 |
| 15 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.33553453 |
| 16 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.33293018 |
| 17 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.27682786 |
| 18 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.27200691 |
| 19 | Measles_Homo sapiens_hsa05162 | 1.26203051 |
| 20 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.25660329 |
| 21 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.22069119 |
| 22 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.20520531 |
| 23 | Influenza A_Homo sapiens_hsa05164 | 1.20392941 |
| 24 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.18388622 |
| 25 | Malaria_Homo sapiens_hsa05144 | 1.13766892 |
| 26 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.13497419 |
| 27 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.11902917 |
| 28 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.09230605 |
| 29 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 1.08579456 |
| 30 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.08481807 |
| 31 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 1.07393595 |
| 32 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.04289995 |
| 33 | Hepatitis B_Homo sapiens_hsa05161 | 1.01126266 |
| 34 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.00268562 |
| 35 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.98805155 |
| 36 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.98744847 |
| 37 | Pertussis_Homo sapiens_hsa05133 | 0.97551438 |
| 38 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.97382989 |
| 39 | Salmonella infection_Homo sapiens_hsa05132 | 0.96485989 |
| 40 | Other glycan degradation_Homo sapiens_hsa00511 | 0.96252420 |
| 41 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.94046879 |
| 42 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.93534179 |
| 43 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.92405306 |
| 44 | Long-term potentiation_Homo sapiens_hsa04720 | 0.91974021 |
| 45 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.91672129 |
| 46 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.91352330 |
| 47 | Platelet activation_Homo sapiens_hsa04611 | 0.90763538 |
| 48 | Renin secretion_Homo sapiens_hsa04924 | 0.89286179 |
| 49 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.88925130 |
| 50 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.87745613 |
| 51 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.86243173 |
| 52 | Viral myocarditis_Homo sapiens_hsa05416 | 0.86237368 |
| 53 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.86051204 |
| 54 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.85876917 |
| 55 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.85755888 |
| 56 | Phagosome_Homo sapiens_hsa04145 | 0.85745427 |
| 57 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.85356241 |
| 58 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.84810466 |
| 59 | Allograft rejection_Homo sapiens_hsa05330 | 0.84498050 |
| 60 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.84361011 |
| 61 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.83779140 |
| 62 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.83289182 |
| 63 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.81775750 |
| 64 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.80850523 |
| 65 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.80517887 |
| 66 | Hepatitis C_Homo sapiens_hsa05160 | 0.79123178 |
| 67 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.79085754 |
| 68 | Insulin resistance_Homo sapiens_hsa04931 | 0.78987898 |
| 69 | Circadian rhythm_Homo sapiens_hsa04710 | 0.78265260 |
| 70 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.77198893 |
| 71 | Glioma_Homo sapiens_hsa05214 | 0.76069801 |
| 72 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.76036866 |
| 73 | Morphine addiction_Homo sapiens_hsa05032 | 0.75752900 |
| 74 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.75693803 |
| 75 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.74100904 |
| 76 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.73999611 |
| 77 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.73867452 |
| 78 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.73567869 |
| 79 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.73168267 |
| 80 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.72955733 |
| 81 | Adherens junction_Homo sapiens_hsa04520 | 0.72947137 |
| 82 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.72808964 |
| 83 | Endometrial cancer_Homo sapiens_hsa05213 | 0.72408260 |
| 84 | Apoptosis_Homo sapiens_hsa04210 | 0.70954564 |
| 85 | Amoebiasis_Homo sapiens_hsa05146 | 0.70862952 |
| 86 | Prostate cancer_Homo sapiens_hsa05215 | 0.70716599 |
| 87 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.70641466 |
| 88 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.70289232 |
| 89 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.68855119 |
| 90 | Legionellosis_Homo sapiens_hsa05134 | 0.68612378 |
| 91 | Salivary secretion_Homo sapiens_hsa04970 | 0.68024929 |
| 92 | Mineral absorption_Homo sapiens_hsa04978 | 0.65442571 |
| 93 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.64622229 |
| 94 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.64099178 |
| 95 | Asthma_Homo sapiens_hsa05310 | 0.64011795 |
| 96 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.63192008 |
| 97 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.63065433 |
| 98 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.62951881 |
| 99 | Long-term depression_Homo sapiens_hsa04730 | 0.62783287 |
| 100 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.62427443 |
| 101 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.62194006 |
| 102 | Lysosome_Homo sapiens_hsa04142 | 0.61559191 |
| 103 | Olfactory transduction_Homo sapiens_hsa04740 | 0.61338963 |
| 104 | Circadian entrainment_Homo sapiens_hsa04713 | 0.60771417 |
| 105 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.60010723 |
| 106 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.59114311 |
| 107 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.58763723 |
| 108 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.58644435 |
| 109 | Colorectal cancer_Homo sapiens_hsa05210 | 0.58412210 |
| 110 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.57773039 |
| 111 | Thyroid cancer_Homo sapiens_hsa05216 | 0.56574621 |
| 112 | Shigellosis_Homo sapiens_hsa05131 | 0.55379159 |
| 113 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.55227684 |
| 114 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.54790420 |
| 115 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.53253300 |
| 116 | Endocytosis_Homo sapiens_hsa04144 | 0.46917042 |
| 117 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.45952040 |
| 118 | HTLV-I infection_Homo sapiens_hsa05166 | 0.40659024 |

