KDM8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)7.52840204
2omega-hydroxylase P450 pathway (GO:0097267)6.32733254
3exogenous drug catabolic process (GO:0042738)6.29613050
4drug catabolic process (GO:0042737)5.90042730
5fat-soluble vitamin biosynthetic process (GO:0042362)5.69592132
6complement activation, alternative pathway (GO:0006957)5.69407020
7cellular extravasation (GO:0045123)5.51935236
8urea metabolic process (GO:0019627)5.33113015
9glyoxylate metabolic process (GO:0046487)5.08998433
10ribosomal small subunit assembly (GO:0000028)5.07081131
11regulation of triglyceride catabolic process (GO:0010896)4.97111053
12nitrogen cycle metabolic process (GO:0071941)4.89709344
13urea cycle (GO:0000050)4.84696938
14drug metabolic process (GO:0017144)4.84224263
15regulation of protein activation cascade (GO:2000257)4.65027927
16regulation of fibrinolysis (GO:0051917)4.60017414
17regulation of complement activation (GO:0030449)4.43199125
18CENP-A containing nucleosome assembly (GO:0034080)4.41690463
19negative regulation of fibrinolysis (GO:0051918)4.37513925
20ethanol oxidation (GO:0006069)4.33541840
21negative regulation of fibroblast apoptotic process (GO:2000270)4.26653601
22positive regulation of triglyceride lipase activity (GO:0061365)4.18171776
23positive regulation of lipoprotein lipase activity (GO:0051006)4.18171776
24L-phenylalanine catabolic process (GO:0006559)4.16874298
25erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.16874298
26chromatin remodeling at centromere (GO:0031055)4.15508808
27somatic hypermutation of immunoglobulin genes (GO:0016446)4.14825584
28somatic diversification of immune receptors via somatic mutation (GO:0002566)4.14825584
29acute-phase response (GO:0006953)4.10684982
30DNA strand elongation involved in DNA replication (GO:0006271)4.09978714
31DNA unwinding involved in DNA replication (GO:0006268)4.08108801
32protein carboxylation (GO:0018214)4.02554056
33peptidyl-glutamic acid carboxylation (GO:0017187)4.02554056
34serine family amino acid catabolic process (GO:0009071)4.01826597
35glycine metabolic process (GO:0006544)4.01663027
36killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.99753491
37disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.99753491
38L-phenylalanine metabolic process (GO:0006558)3.95194450
39erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.95194450
40cellular glucuronidation (GO:0052695)3.93435836
41telomere maintenance via semi-conservative replication (GO:0032201)3.92485563
42T cell migration (GO:0072678)3.89485355
43glucuronate metabolic process (GO:0019585)3.86993363
44uronic acid metabolic process (GO:0006063)3.86993363
45NADH metabolic process (GO:0006734)3.86782472
46DNA strand elongation (GO:0022616)3.85738493
47angiotensin maturation (GO:0002003)3.84645454
48protein localization to kinetochore (GO:0034501)3.84545683
49formation of translation preinitiation complex (GO:0001731)3.82871625
50hepatocyte apoptotic process (GO:0097284)3.78655043
51mitotic nuclear envelope disassembly (GO:0007077)3.77353132
52diacylglycerol metabolic process (GO:0046339)3.74344637
53fructose metabolic process (GO:0006000)3.73744705
54rRNA modification (GO:0000154)3.72990728
55ethanol metabolic process (GO:0006067)3.72168719
56hormone catabolic process (GO:0042447)3.71750033
57DNA replication-independent nucleosome assembly (GO:0006336)3.70075042
58DNA replication-independent nucleosome organization (GO:0034724)3.70075042
59IMP biosynthetic process (GO:0006188)3.69971005
60regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.66446218
61triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.65252261
62phospholipid efflux (GO:0033700)3.58578835
63oxidative demethylation (GO:0070989)3.57961118
64DNA replication initiation (GO:0006270)3.53437267
65rRNA methylation (GO:0031167)3.50618196
66maturation of SSU-rRNA (GO:0030490)3.48020658
67DNA deamination (GO:0045006)3.47472703
68bile acid metabolic process (GO:0008206)3.46677311
69mitotic metaphase plate congression (GO:0007080)3.44216861
70ribosomal small subunit biogenesis (GO:0042274)3.44165322
71mitotic chromosome condensation (GO:0007076)3.43448390
72very-low-density lipoprotein particle assembly (GO:0034379)3.43216510
73regulation of spindle organization (GO:0090224)3.41276722
74negative regulation of sterol transport (GO:0032372)3.40876137
75negative regulation of cholesterol transport (GO:0032375)3.40876137
76histone exchange (GO:0043486)3.40866847
77mitotic sister chromatid segregation (GO:0000070)3.40665685
78membrane disassembly (GO:0030397)3.40539779
79nuclear envelope disassembly (GO:0051081)3.40539779
80telomere maintenance via recombination (GO:0000722)3.40043000
81vitamin biosynthetic process (GO:0009110)3.37609833
82bile acid and bile salt transport (GO:0015721)3.36615139
83nucleobase biosynthetic process (GO:0046112)3.36433385
84complement activation (GO:0006956)3.36368634
85complement activation, classical pathway (GO:0006958)3.32712450
86viral transcription (GO:0019083)3.32575651
87translational termination (GO:0006415)3.31748541
88attachment of spindle microtubules to kinetochore (GO:0008608)3.31488364
89protein activation cascade (GO:0072376)3.30080756
90mitotic recombination (GO:0006312)3.29992364
91plasma lipoprotein particle assembly (GO:0034377)3.29579373
92ribosome biogenesis (GO:0042254)3.29475293
93DNA replication checkpoint (GO:0000076)3.29289418
94rRNA processing (GO:0006364)3.28235550
95ribonucleoprotein complex biogenesis (GO:0022613)3.26822366
96IMP metabolic process (GO:0046040)3.26660577
97plasma lipoprotein particle remodeling (GO:0034369)3.26086627
98protein-lipid complex remodeling (GO:0034368)3.26086627
99macromolecular complex remodeling (GO:0034367)3.26086627
100protein localization to chromosome, centromeric region (GO:0071459)3.24304587
101regulation of bile acid biosynthetic process (GO:0070857)3.23874248
102regulation of humoral immune response (GO:0002920)3.23064458
103ribosomal large subunit biogenesis (GO:0042273)3.23046736
104imidazole-containing compound metabolic process (GO:0052803)3.22588283
105folic acid-containing compound biosynthetic process (GO:0009396)3.22474556
106cytolysis (GO:0019835)3.21930035
107proline metabolic process (GO:0006560)3.21249449
108coenzyme catabolic process (GO:0009109)3.20410853
109mast cell activation involved in immune response (GO:0002279)3.19632511
110mast cell degranulation (GO:0043303)3.19632511
111opsonization (GO:0008228)3.18677874
112regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.18087630
113deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.17916559
114purine nucleobase biosynthetic process (GO:0009113)3.15553282
115blood coagulation, intrinsic pathway (GO:0007597)3.15043390
116DNA replication-dependent nucleosome organization (GO:0034723)3.14112841
117DNA replication-dependent nucleosome assembly (GO:0006335)3.14112841
118high-density lipoprotein particle remodeling (GO:0034375)3.13649880
119translational elongation (GO:0006414)3.13240408
120rRNA metabolic process (GO:0016072)3.12699457
121antigen processing and presentation of endogenous antigen (GO:0019883)3.11809850
122snRNA processing (GO:0016180)3.11655277
123sister chromatid segregation (GO:0000819)3.11336980
124bile acid biosynthetic process (GO:0006699)3.11157389
125antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.11030247
126cholesterol efflux (GO:0033344)3.09835966
127fibrinolysis (GO:0042730)3.07524167
128mucosal-associated lymphoid tissue development (GO:0048537)3.07132119
129Peyers patch development (GO:0048541)3.07132119
130antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.06863640
131nuclear pore organization (GO:0006999)3.05025392
132metaphase plate congression (GO:0051310)3.04651269
133protein-lipid complex assembly (GO:0065005)3.03888220
134telomere maintenance via telomere lengthening (GO:0010833)3.01911085
135snRNA metabolic process (GO:0016073)3.00848330
136ncRNA 3-end processing (GO:0043628)2.99832851
137aromatic amino acid family catabolic process (GO:0009074)2.99737398
138translational initiation (GO:0006413)2.99140036
139positive regulation of fatty acid biosynthetic process (GO:0045723)2.98193777
140lipoprotein transport (GO:0042953)2.96480351
141alkaloid metabolic process (GO:0009820)2.96453716
142heme transport (GO:0015886)2.96438656
143regulation of translational termination (GO:0006449)2.95532702
144regulation of cholesterol esterification (GO:0010872)2.94451811
145glutamate metabolic process (GO:0006536)2.94003729
146kinetochore organization (GO:0051383)2.92413024
147regulation of fibroblast apoptotic process (GO:2000269)2.92219195
148SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.92188899
149establishment of chromosome localization (GO:0051303)2.92152827
150negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.91894276
151chromatin assembly or disassembly (GO:0006333)2.88774278
152plasma lipoprotein particle organization (GO:0071827)2.88416810
153nucleotide-excision repair, DNA gap filling (GO:0006297)2.86486964
154anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.85672458
155serine family amino acid metabolic process (GO:0009069)2.85379465
156regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.85185711
157nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.84833474
158fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.84439832
159cotranslational protein targeting to membrane (GO:0006613)2.83289460
160quinone biosynthetic process (GO:1901663)2.82611187
161glutamine family amino acid biosynthetic process (GO:0009084)2.82542101
162protoporphyrinogen IX biosynthetic process (GO:0006782)2.81291124
163negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.80987306
164protein targeting to ER (GO:0045047)2.80590603
165regulation of lipoprotein particle clearance (GO:0010984)2.80283254
166negative regulation of hemostasis (GO:1900047)2.79843801
167negative regulation of blood coagulation (GO:0030195)2.79843801
168DNA duplex unwinding (GO:0032508)2.79779680
169oxaloacetate metabolic process (GO:0006107)2.79747290
170regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.78835466
171RNA splicing, via transesterification reactions (GO:0000375)2.78395087
172proline biosynthetic process (GO:0006561)2.78003437
173amino-acid betaine metabolic process (GO:0006577)2.77002536
174spindle assembly checkpoint (GO:0071173)2.76933324
175RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.76904030
176mRNA splicing, via spliceosome (GO:0000398)2.76904030
177protein-lipid complex subunit organization (GO:0071825)2.76898155
178viral mRNA export from host cell nucleus (GO:0046784)2.75558419
179negative regulation of chromosome segregation (GO:0051985)2.75122457
180somatic diversification of immunoglobulins (GO:0016445)2.74674338
181regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.74627746
182cellular protein complex disassembly (GO:0043624)2.74064336
183DNA geometric change (GO:0032392)2.74054680
184cofactor catabolic process (GO:0051187)2.73662748
185negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.72996702
186negative regulation of ligase activity (GO:0051352)2.72996702
187mitotic spindle assembly checkpoint (GO:0007094)2.72590529
188negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.72530194
189negative regulation of sister chromatid segregation (GO:0033046)2.72530194
190negative regulation of mitotic sister chromatid separation (GO:2000816)2.72530194
191negative regulation of mitotic sister chromatid segregation (GO:0033048)2.72530194
192protoporphyrinogen IX metabolic process (GO:0046501)2.71772966
193positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.70924977
194mismatch repair (GO:0006298)2.70664584
195reverse cholesterol transport (GO:0043691)2.70407296
196spindle checkpoint (GO:0031577)2.70239744
197lipoprotein metabolic process (GO:0042157)2.69739132
198mannose metabolic process (GO:0006013)2.69574301
199flavonoid metabolic process (GO:0009812)2.69057004
200S-adenosylmethionine metabolic process (GO:0046500)2.66634381

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.80974945
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.83222685
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.15925651
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.01466350
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.71906945
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.07984082
7RXR_22158963_ChIP-Seq_LIVER_Mouse3.07875599
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.05359204
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.95807998
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.91157122
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.90953991
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.81665826
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.70292923
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.67562570
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.66726476
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.55184180
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.50914171
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.48660686
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.46307074
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.46010928
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.42592471
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35241031
23FOXP3_21729870_ChIP-Seq_TREG_Human2.31056105
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.28464460
25MYC_22102868_ChIP-Seq_BL_Human2.22809006
26VDR_23849224_ChIP-Seq_CD4+_Human2.22694189
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22370941
28FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.15764805
29LXR_22158963_ChIP-Seq_LIVER_Mouse2.11627299
30XRN2_22483619_ChIP-Seq_HELA_Human2.11086446
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.08683684
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.08253685
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.98048240
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.95237509
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.89163660
36GABP_19822575_ChIP-Seq_HepG2_Human1.87697113
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85333609
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.84501162
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83527991
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.82181847
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.81267327
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80903084
43DCP1A_22483619_ChIP-Seq_HELA_Human1.80303056
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80280784
45CIITA_25753668_ChIP-Seq_RAJI_Human1.79755989
46MAF_26560356_Chip-Seq_TH2_Human1.76723840
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75181649
48LXR_22292898_ChIP-Seq_THP-1_Human1.75036784
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.74400068
50VDR_21846776_ChIP-Seq_THP-1_Human1.73604400
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.72371320
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.71606135
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.70576005
54AR_21909140_ChIP-Seq_LNCAP_Human1.69807633
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69615007
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.67513318
57STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.65710771
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.65677378
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62815927
60VDR_24763502_ChIP-Seq_THP-1_Human1.62450418
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60421268
62BP1_19119308_ChIP-ChIP_Hs578T_Human1.60257381
63E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57854836
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57654407
65TTF2_22483619_ChIP-Seq_HELA_Human1.57344185
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.55670343
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53726813
68IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.51269589
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.50848353
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.50002353
71BCL6_27268052_Chip-Seq_Bcells_Human1.48220731
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.47926083
73BCOR_27268052_Chip-Seq_Bcells_Human1.47345325
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.47327989
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47032910
76ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45923695
77MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.45236204
78KDM5A_27292631_Chip-Seq_BREAST_Human1.42589841
79ELK1_19687146_ChIP-ChIP_HELA_Human1.40866256
80SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.38846303
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37173456
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36794850
83TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35884149
84ELF1_20517297_ChIP-Seq_JURKAT_Human1.34741351
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.34023112
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32558491
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32093188
88P68_20966046_ChIP-Seq_HELA_Human1.31440703
89NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31302279
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30576678
91ELK3_25401928_ChIP-Seq_HUVEC_Human1.30090970
92SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28211197
93YY1_21170310_ChIP-Seq_MESCs_Mouse1.27274607
94TFEB_21752829_ChIP-Seq_HELA_Human1.27184489
95SPI1_23547873_ChIP-Seq_NB4_Human1.26398781
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25447280
97SCL_19346495_ChIP-Seq_HPC-7_Human1.24712068
98TET1_21451524_ChIP-Seq_MESCs_Mouse1.23621944
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22133996
100RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22053162
101STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19848102
102E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18083296
103KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.17792709
104CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17175868
105PHF8_20622854_ChIP-Seq_HELA_Human1.16579161
106NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15629268
107TCF7_22412390_ChIP-Seq_EML_Mouse1.15535332
108RACK7_27058665_Chip-Seq_MCF-7_Human1.14764868
109CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14316292
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13821037
111PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12719622
112SA1_27219007_Chip-Seq_Bcells_Human1.12409369
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12343026
114KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11703415
115DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10906903
116MAF_26560356_Chip-Seq_TH1_Human1.09007397
117BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08728455
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08725211
119SPI1_20517297_ChIP-Seq_HL60_Human1.08614250
120ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07980358
121MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07916278
122SA1_27219007_Chip-Seq_ERYTHROID_Human1.07741711
123CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07549501
124PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06653367
125SMC4_20622854_ChIP-Seq_HELA_Human1.05984656
126CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05636342
127GATA1_22025678_ChIP-Seq_K562_Human1.05403938
128CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05013742
129KDM2B_26808549_Chip-Seq_DND41_Human1.04253555
130NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03867935
131GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03806914
132SPI1_23127762_ChIP-Seq_K562_Human1.03690877
133IRF8_22096565_ChIP-ChIP_GC-B_Human1.03569193
134CTCF_21964334_ChIP-Seq_BJAB-B_Human1.03179211
135TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03164971
136UTX_26944678_Chip-Seq_JUKART_Human1.02995533
137ETS1_21867929_ChIP-Seq_TH2_Mouse1.02742071
138GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02052758
139CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01900759
140SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01606185
141MYB_26560356_Chip-Seq_TH2_Human1.01416022
142CTCF_21964334_Chip-Seq_Bcells_Human1.00913224
143MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00670389
144E2F1_20622854_ChIP-Seq_HELA_Human1.00476632
145TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.99406353
146P300_27268052_Chip-Seq_Bcells_Human0.99061510
147CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99002688
148MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98616864
149HNF4A_19822575_ChIP-Seq_HepG2_Human0.98012857
150RUNX1_22412390_ChIP-Seq_EML_Mouse0.97850259
151CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97799233
152SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97771352
153NCOR1_26117541_ChIP-Seq_K562_Human0.96664862
154DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96223379
155SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95977672
156STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95876942
157GATA1_19941827_ChIP-Seq_MEL_Mouse0.95255313
158KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92746486
159HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92485839
160MYC_18940864_ChIP-ChIP_HL60_Human0.91909208
161MYB_26560356_Chip-Seq_TH1_Human0.91821695
162CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91676369
163GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88814966
164TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88263332
165POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.86244441

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.39222016
2MP0002139_abnormal_hepatobiliary_system6.29633419
3MP0003693_abnormal_embryo_hatching4.38190940
4MP0005365_abnormal_bile_salt4.25008950
5MP0010094_abnormal_chromosome_stability4.16678734
6MP0005085_abnormal_gallbladder_physiolo3.91327632
7MP0003111_abnormal_nucleus_morphology3.73659373
8MP0001666_abnormal_nutrient_absorption3.47685467
9MP0002396_abnormal_hematopoietic_system3.45892929
10MP0003077_abnormal_cell_cycle3.28542902
11MP0004957_abnormal_blastocyst_morpholog3.14948638
12MP0008875_abnormal_xenobiotic_pharmacok3.06175060
13MP0008058_abnormal_DNA_repair2.88887676
14MP0008007_abnormal_cellular_replicative2.77790906
15MP0003191_abnormal_cellular_cholesterol2.52860127
16MP0008057_abnormal_DNA_replication2.52619828
17MP0004808_abnormal_hematopoietic_stem2.51899442
18MP0003868_abnormal_feces_composition2.50146191
19MP0003436_decreased_susceptibility_to2.39683283
20MP0003763_abnormal_thymus_physiology2.34573123
21MP0004233_abnormal_muscle_weight2.30462240
22MP0008877_abnormal_DNA_methylation2.28970062
23MP0001764_abnormal_homeostasis2.19528155
24MP0010329_abnormal_lipoprotein_level2.14837502
25MP0004147_increased_porphyrin_level2.13536098
26MP0003656_abnormal_erythrocyte_physiolo2.10733279
27MP0005451_abnormal_body_composition2.09751815
28MP0002398_abnormal_bone_marrow2.09282290
29MP0005058_abnormal_lysosome_morphology2.08280891
30MP0002138_abnormal_hepatobiliary_system2.07797841
31MP0003806_abnormal_nucleotide_metabolis2.06216095
32MP0009333_abnormal_splenocyte_physiolog2.02217131
33MP0008932_abnormal_embryonic_tissue1.98923160
34MP0003252_abnormal_bile_duct1.96401618
35MP0005671_abnormal_response_to1.91614533
36MP0004084_abnormal_cardiac_muscle1.88147282
37MP0000703_abnormal_thymus_morphology1.84728841
38MP0002722_abnormal_immune_system1.83040177
39MP0005332_abnormal_amino_acid1.82225961
40MP0000689_abnormal_spleen_morphology1.75050412
41MP0000609_abnormal_liver_physiology1.74642913
42MP0001730_embryonic_growth_arrest1.74423007
43MP0001800_abnormal_humoral_immune1.72846978
44MP0000350_abnormal_cell_proliferation1.72456584
45MP0009840_abnormal_foam_cell1.66747700
46MP0005464_abnormal_platelet_physiology1.66522425
47MP0001835_abnormal_antigen_presentation1.65693276
48MP0001545_abnormal_hematopoietic_system1.64798768
49MP0005397_hematopoietic_system_phenotyp1.64798768
50MP0000490_abnormal_crypts_of1.60388297
51MP0003943_abnormal_hepatobiliary_system1.59802590
52MP0002429_abnormal_blood_cell1.57562477
53MP0005075_abnormal_melanosome_morpholog1.56495559
54MP0003123_paternal_imprinting1.55259731
55MP0003786_premature_aging1.53994516
56MP0004019_abnormal_vitamin_homeostasis1.52838488
57MP0009785_altered_susceptibility_to1.50838471
58MP0000716_abnormal_immune_system1.47935155
59MP0002452_abnormal_antigen_presenting1.46406442
60MP0003195_calcinosis1.43134034
61MP0002420_abnormal_adaptive_immunity1.42735481
62MP0002019_abnormal_tumor_incidence1.42292829
63MP0009697_abnormal_copulation1.42159245
64MP0001819_abnormal_immune_cell1.39124009
65MP0002118_abnormal_lipid_homeostasis1.37082149
66MP0010307_abnormal_tumor_latency1.37012493
67MP0002876_abnormal_thyroid_physiology1.36171727
68MP0001697_abnormal_embryo_size1.35530831
69MP0008469_abnormal_protein_level1.34906818
70MP0005000_abnormal_immune_tolerance1.33163873
71MP0000685_abnormal_immune_system1.32967071
72MP0000313_abnormal_cell_death1.30490281
73MP0002723_abnormal_immune_serum1.28743745
74MP0002080_prenatal_lethality1.28341876
75MP0010352_gastrointestinal_tract_polyps1.26547304
76MP0005023_abnormal_wound_healing1.26014264
77MP0003303_peritoneal_inflammation1.25121186
78MP0009643_abnormal_urine_homeostasis1.24122046
79MP0009278_abnormal_bone_marrow1.21471530
80MP0005584_abnormal_enzyme/coenzyme_acti1.17368636
81MP0005025_abnormal_response_to1.15925133
82MP0003866_abnormal_defecation1.12170931
83MP0002132_abnormal_respiratory_system1.11229100
84MP0001661_extended_life_span1.10092069
85MP0003172_abnormal_lysosome_physiology1.09172036
86MP0006036_abnormal_mitochondrial_physio1.08644840
87MP0005380_embryogenesis_phenotype1.07853481
88MP0001672_abnormal_embryogenesis/_devel1.07853481
89MP0004036_abnormal_muscle_relaxation1.04711458
90MP0005166_decreased_susceptibility_to1.04607856
91MP0004264_abnormal_extraembryonic_tissu1.04577818
92MP0003984_embryonic_growth_retardation1.03704630
93MP0010155_abnormal_intestine_physiology1.02304106
94MP0001853_heart_inflammation1.01980194
95MP0000750_abnormal_muscle_regeneration1.01398607
96MP0005076_abnormal_cell_differentiation1.00408971
97MP0005319_abnormal_enzyme/_coenzyme1.00402786
98MP0002088_abnormal_embryonic_growth/wei0.99296864
99MP0003183_abnormal_peptide_metabolism0.98410409
100MP0002095_abnormal_skin_pigmentation0.96935689
101MP0002086_abnormal_extraembryonic_tissu0.96100867
102MP0003567_abnormal_fetal_cardiomyocyte0.95539215
103MP0002405_respiratory_system_inflammati0.93873196
104MP0001849_ear_inflammation0.92375785
105MP0003890_abnormal_embryonic-extraembry0.91483837
106MP0000465_gastrointestinal_hemorrhage0.90417686
107MP0002419_abnormal_innate_immunity0.90261417
108MP0006292_abnormal_olfactory_placode0.89590735
109MP0005376_homeostasis/metabolism_phenot0.89521742
110MP0003718_maternal_effect0.88724546
111MP0009642_abnormal_blood_homeostasis0.88460939
112MP0000858_altered_metastatic_potential0.86819327
113MP0009764_decreased_sensitivity_to0.86248627
114MP0005636_abnormal_mineral_homeostasis0.84639760
115MP0001845_abnormal_inflammatory_respons0.82135944
116MP0002148_abnormal_hypersensitivity_rea0.81996586
117MP0004197_abnormal_fetal_growth/weight/0.80699107
118MP0002085_abnormal_embryonic_tissue0.80250686
119MP0005621_abnormal_cell_physiology0.80068081
120MP0000372_irregular_coat_pigmentation0.79602161
121MP0001790_abnormal_immune_system0.79162012
122MP0005387_immune_system_phenotype0.79162012
123MP0009763_increased_sensitivity_to0.78928890
124MP0005384_cellular_phenotype0.77587283
125MP0000358_abnormal_cell_content/0.77540247
126MP0005266_abnormal_metabolism0.76670724
127MP0002877_abnormal_melanocyte_morpholog0.76325319
128MP0001533_abnormal_skeleton_physiology0.73555486
129MP0000598_abnormal_liver_morphology0.72277999
130MP0002269_muscular_atrophy0.71604945
131MP0002933_joint_inflammation0.71059530
132MP0002249_abnormal_larynx_morphology0.70288439
133MP0009672_abnormal_birth_weight0.69759518
134MP0000749_muscle_degeneration0.68826393
135MP0002971_abnormal_brown_adipose0.68377336
136MP0003724_increased_susceptibility_to0.67844257
137MP0001243_abnormal_dermal_layer0.67387060
138MP0003646_muscle_fatigue0.66925510
139MP0001873_stomach_inflammation0.66705815
140MP0000678_abnormal_parathyroid_gland0.66114629
141MP0003300_gastrointestinal_ulcer0.65383089
142MP0002822_catalepsy0.63154444
143MP0000477_abnormal_intestine_morphology0.62438085
144MP0006035_abnormal_mitochondrial_morpho0.61759452
145MP0002210_abnormal_sex_determination0.61452765
146MP0002084_abnormal_developmental_patter0.61214777
147MP0001664_abnormal_digestion0.60991549
148MP0008873_increased_physiological_sensi0.60844630
149MP0005395_other_phenotype0.60600179
150MP0002136_abnormal_kidney_physiology0.59990938
151MP0003879_abnormal_hair_cell0.58976292
152MP0009115_abnormal_fat_cell0.57402459
153MP0002078_abnormal_glucose_homeostasis0.57050463
154MP0002166_altered_tumor_susceptibility0.56701762

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)6.15269497
2Complement deficiency (HP:0004431)5.95778793
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.81547896
4Prolonged partial thromboplastin time (HP:0003645)5.61697988
5Cerebellar dysplasia (HP:0007033)5.58131058
6Abnormality of complement system (HP:0005339)4.98571299
7Deep venous thrombosis (HP:0002625)4.85994566
8Systemic lupus erythematosus (HP:0002725)4.81396495
9Joint hemorrhage (HP:0005261)4.50211090
10Anterior segment dysgenesis (HP:0007700)4.49515586
11Ependymoma (HP:0002888)4.41043452
12Xanthomatosis (HP:0000991)4.24889820
13Abnormality of aromatic amino acid family metabolism (HP:0004338)4.10838950
14Abnormality of the intrinsic pathway (HP:0010989)4.04579438
15Abnormality of glutamine family amino acid metabolism (HP:0010902)3.99930101
16Abnormality of pyrimidine metabolism (HP:0004353)3.96199569
17Agnosia (HP:0010524)3.91467206
18Hyperlipoproteinemia (HP:0010980)3.76911221
19Recurrent gram-negative bacterial infections (HP:0005420)3.75822190
20Medulloblastoma (HP:0002885)3.68195396
21Type II lissencephaly (HP:0007260)3.54637115
22Hypoplasia of the capital femoral epiphysis (HP:0003090)3.51286091
23Amaurosis fugax (HP:0100576)3.48247330
24Abnormality of the heme biosynthetic pathway (HP:0010472)3.48054968
25Prostate neoplasm (HP:0100787)3.43983463
26Conjugated hyperbilirubinemia (HP:0002908)3.42353326
27Abnormal number of erythroid precursors (HP:0012131)3.38752344
28Selective tooth agenesis (HP:0001592)3.35979067
29Birth length less than 3rd percentile (HP:0003561)3.34899145
30Orchitis (HP:0100796)3.33061794
31Retrobulbar optic neuritis (HP:0100654)3.30778032
32Optic neuritis (HP:0100653)3.30778032
33Myositis (HP:0100614)3.20264447
34Hypolipoproteinemia (HP:0010981)3.18461169
35Abnormality of cells of the erythroid lineage (HP:0012130)3.16626948
36Gastrointestinal stroma tumor (HP:0100723)3.16277056
37Bundle branch block (HP:0011710)3.16131100
38Aplastic anemia (HP:0001915)3.01209571
39Eczematoid dermatitis (HP:0000976)3.00982684
40Thrombocytosis (HP:0001894)2.99906958
41Lymphoma (HP:0002665)2.99706772
42Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.97811870
43Abnormality of glycine metabolism (HP:0010895)2.96486286
44Abnormality of serine family amino acid metabolism (HP:0010894)2.96486286
45IgM deficiency (HP:0002850)2.93125238
46Cerebral hypomyelination (HP:0006808)2.89201824
47Hyperglycinuria (HP:0003108)2.87649866
48B lymphocytopenia (HP:0010976)2.85109937
49Abnormality of B cell number (HP:0010975)2.85109937
50Glomerulonephritis (HP:0000099)2.84160015
51Reduced antithrombin III activity (HP:0001976)2.82562013
52Hemorrhage of the eye (HP:0011885)2.76926092
53Intrahepatic cholestasis (HP:0001406)2.76539096
54Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.73821655
55Absent epiphyses (HP:0010577)2.73821655
56Rhabdomyosarcoma (HP:0002859)2.70876314
57Fat malabsorption (HP:0002630)2.70572084
58Reticulocytopenia (HP:0001896)2.69207977
59Abnormality of the prostate (HP:0008775)2.69164266
60Hyperammonemia (HP:0001987)2.66169446
61Muscle fiber atrophy (HP:0100295)2.64674730
62Ketosis (HP:0001946)2.61269691
63Colitis (HP:0002583)2.59752040
64Wrist flexion contracture (HP:0001239)2.57018808
65Increased serum ferritin (HP:0003281)2.56060667
66Malnutrition (HP:0004395)2.55156391
6711 pairs of ribs (HP:0000878)2.54976431
68Abnormality of the common coagulation pathway (HP:0010990)2.54645847
69Panhypogammaglobulinemia (HP:0003139)2.54085017
70Generalized aminoaciduria (HP:0002909)2.52952285
71Meningitis (HP:0001287)2.49822521
72Encephalitis (HP:0002383)2.47915303
73Hyperglycinemia (HP:0002154)2.47150418
74Basal cell carcinoma (HP:0002671)2.44300220
75Nephritis (HP:0000123)2.44248066
76Abnormality of the astrocytes (HP:0100707)2.42858598
77Astrocytoma (HP:0009592)2.42858598
78Thrombophlebitis (HP:0004418)2.40180933
79Hyperbilirubinemia (HP:0002904)2.39438717
80Abnormality of nucleobase metabolism (HP:0010932)2.36331585
81Petechiae (HP:0000967)2.34742284
82Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.33615785
83Severe visual impairment (HP:0001141)2.33502309
84Hypercholesterolemia (HP:0003124)2.32312924
85Degeneration of anterior horn cells (HP:0002398)2.30828035
86Abnormality of the anterior horn cell (HP:0006802)2.30828035
87IgG deficiency (HP:0004315)2.30237266
88Type 2 muscle fiber atrophy (HP:0003554)2.29144123
89Abnormal lung lobation (HP:0002101)2.29143475
90Neoplasm of the rectum (HP:0100743)2.28251959
91Pulmonary embolism (HP:0002204)2.27556030
92Abnormality of iron homeostasis (HP:0011031)2.27256738
93Pancreatitis (HP:0001733)2.24348091
94Increased neuronal autofluorescent lipopigment (HP:0002074)2.23915857
95Chronic otitis media (HP:0000389)2.22328364
96Lymphopenia (HP:0001888)2.22321046
97Metabolic acidosis (HP:0001942)2.21272244
98Oral leukoplakia (HP:0002745)2.20591035
99Delayed CNS myelination (HP:0002188)2.20508455
100Joint swelling (HP:0001386)2.19638798
101T lymphocytopenia (HP:0005403)2.19025328
102Abnormality of cells of the lymphoid lineage (HP:0012140)2.19004392
103Hydroxyprolinuria (HP:0003080)2.15406318
104Abnormality of proline metabolism (HP:0010907)2.15406318
105Widely patent fontanelles and sutures (HP:0004492)2.14731171
106Keratoconjunctivitis sicca (HP:0001097)2.13499531
107Neoplasm of the pancreas (HP:0002894)2.13489424
108Neoplasm of the colon (HP:0100273)2.12610189
109Abnormality of T cells (HP:0002843)2.09929291
110Type I transferrin isoform profile (HP:0003642)2.08867044
111Inflammation of the large intestine (HP:0002037)2.07483516
112Long clavicles (HP:0000890)2.05903013
113Purpura (HP:0000979)2.05144593
114Acute myeloid leukemia (HP:0004808)2.04229889
115Steatorrhea (HP:0002570)2.04223483
116Gastrointestinal inflammation (HP:0004386)2.03752235
117Abnormality of vitamin metabolism (HP:0100508)2.02741220
118Anorexia (HP:0002039)2.02350052
119Glioma (HP:0009733)2.02217351
120Nasal polyposis (HP:0100582)2.02200852
121Abnormal gallbladder physiology (HP:0012438)2.01794614
122Cholecystitis (HP:0001082)2.01794614
123Chronic diarrhea (HP:0002028)2.01735337
124Gingival bleeding (HP:0000225)2.01502917
125Recurrent sinusitis (HP:0011108)2.00815219
126Abnormality of T cell number (HP:0011839)1.97787570
127Spontaneous abortion (HP:0005268)1.96152541
128Epistaxis (HP:0000421)1.96076716
129Agammaglobulinemia (HP:0004432)1.94567433
130Abnormality of transition element cation homeostasis (HP:0011030)1.94467629
131Recurrent bronchitis (HP:0002837)1.94126845
132Abnormality of sulfur amino acid metabolism (HP:0004339)1.93988873
133Acute lymphatic leukemia (HP:0006721)1.93726124
134Neoplasm of striated muscle (HP:0009728)1.93648005
135Neoplasm of the small intestine (HP:0100833)1.92941109
136Bone marrow hypocellularity (HP:0005528)1.92854503
137Vasculitis (HP:0002633)1.92350471
138Spinal rigidity (HP:0003306)1.92253928
139Rhabdomyolysis (HP:0003201)1.91695523
140Microretrognathia (HP:0000308)1.91522217
141Self-mutilation (HP:0000742)1.90988366
142Keratoconjunctivitis (HP:0001096)1.90185569
143Buphthalmos (HP:0000557)1.90071099
144Arterial thrombosis (HP:0004420)1.89688452
145Abnormality of aspartate family amino acid metabolism (HP:0010899)1.88654364
146Rough bone trabeculation (HP:0100670)1.87440421
147Nonimmune hydrops fetalis (HP:0001790)1.87389446
148Gangrene (HP:0100758)1.86373249
149Severe combined immunodeficiency (HP:0004430)1.85906966
150Premature graying of hair (HP:0002216)1.84174646
151Pallor (HP:0000980)1.83956936
152Hyperphosphaturia (HP:0003109)1.83576541
153Myelodysplasia (HP:0002863)1.82957784
154Abnormality of reticulocytes (HP:0004312)1.82947391
155Abnormal enzyme/coenzyme activity (HP:0012379)1.82775263
156Chromsome breakage (HP:0040012)1.82751087
157Abnormality of urine glucose concentration (HP:0011016)1.82029113
158Glycosuria (HP:0003076)1.82029113
159Acanthocytosis (HP:0001927)1.81006026
160Cellulitis (HP:0100658)1.80643343
161Increased cerebral lipofuscin (HP:0011813)1.80167510
162Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.79861860
163Increased density of long bones (HP:0006392)1.79707401
164Prolonged bleeding time (HP:0003010)1.79700109
165Poikiloderma (HP:0001029)1.79400187
166Cellular immunodeficiency (HP:0005374)1.79358943
167Granulocytopenia (HP:0001913)1.78767074
168Neutropenia (HP:0001875)1.77871369
169Elevated alkaline phosphatase (HP:0003155)1.77842275
170Opisthotonus (HP:0002179)1.76706035
171CNS hypomyelination (HP:0003429)1.76301479
172Optic nerve coloboma (HP:0000588)1.76287829
173Elevated erythrocyte sedimentation rate (HP:0003565)1.76117486
174Abnormal urine phosphate concentration (HP:0012599)1.75944872
175Gout (HP:0001997)1.75497481
176Elevated hepatic transaminases (HP:0002910)1.75149248
177Recurrent viral infections (HP:0004429)1.75086557
178Pulmonary infiltrates (HP:0002113)1.74546040
179Chromosomal breakage induced by crosslinking agents (HP:0003221)1.74349664
180Cafe-au-lait spot (HP:0000957)1.73399183
181Epidermoid cyst (HP:0200040)1.73375798
182Abnormality of alkaline phosphatase activity (HP:0004379)1.73214956
183Recurrent abscess formation (HP:0002722)1.72986830
184Abnormality of the nasal mucosa (HP:0000433)1.72975077
185Decreased activity of mitochondrial respiratory chain (HP:0008972)1.71148679
186Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.71148679
187Abnormal delayed hypersensitivity skin test (HP:0002963)1.70726971
188Biliary tract neoplasm (HP:0100574)1.70494431
189High pitched voice (HP:0001620)1.69805736
190Abnormality of T cell physiology (HP:0011840)1.68873574
191Combined immunodeficiency (HP:0005387)1.67455705
192Macrocytic anemia (HP:0001972)1.67235564
193Abnormal number of incisors (HP:0011064)1.67125990
194Emphysema (HP:0002097)1.66574852
195Abnormality of chromosome stability (HP:0003220)1.66287986
196Heart block (HP:0012722)1.65492391
197Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.62678146

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CG5.99146576
2BUB14.00178747
3MAP3K103.09194955
4FLT32.84398656
5EIF2AK12.70718817
6MAP4K12.51235074
7PRPF4B2.46429981
8CDC72.42283422
9NEK12.41175865
10EEF2K2.39287787
11SMG12.24084715
12FGFR42.22857478
13NEK22.22092493
14WEE12.20737292
15TESK22.11591664
16NLK2.10946944
17BRSK22.03304814
18TSSK61.99247283
19MARK31.93590251
20PINK11.91263133
21SIK11.72055461
22KIT1.68213046
23MAP3K11.56962321
24NME21.55771090
25ICK1.55581483
26BRSK11.53952024
27EPHB11.52830461
28MAPK151.47827582
29PLK11.46633299
30PASK1.43956929
31MAP2K31.42798163
32ACVR1B1.42297547
33RPS6KB21.38339780
34STK161.37641473
35BLK1.35383929
36RIPK41.33632623
37STK101.32983590
38SIK21.30090985
39CSF1R1.26440989
40PKN21.26210160
41ZAP701.25669900
42MAP3K141.25603145
43TNK21.24992743
44NEK91.20548214
45CCNB11.17356885
46BCKDK1.16298007
47PIM21.15397924
48VRK11.13758409
49TXK1.13394865
50AURKB1.12391865
51SCYL21.10831417
52TLK11.09676666
53EPHA31.09401275
54JAK31.09060656
55RPS6KA41.08446262
56TRIB31.07194300
57CLK11.05978590
58SRPK11.05416876
59TGFBR11.04701386
60IKBKE1.04292978
61ITK1.02999910
62NME11.02552211
63EIF2AK31.02288566
64CDK71.01245873
65MKNK11.00636174
66JAK11.00066404
67PRKCQ0.99990901
68ATR0.99661311
69TTK0.96633979
70STK40.95852183
71MATK0.95485587
72KDR0.91712041
73BTK0.91522544
74SIK30.90280724
75FGR0.89714967
76CHEK10.88828389
77PIK3CA0.88017917
78GRK60.86856795
79CDK60.83806988
80PLK40.82077751
81PBK0.80909750
82MAP3K80.80520513
83CDK40.79796769
84CSK0.78707704
85CHEK20.78494779
86ARAF0.77898860
87PDK10.75858890
88JAK20.75823658
89PLK30.75803196
90FGFR30.75429369
91CDC42BPA0.73963533
92CDK120.72556246
93PDPK10.72168065
94VRK20.72117237
95PIM10.71480578
96TAOK20.69026630
97CDK80.65619978
98LRRK20.65274518
99MAP3K110.65186280
100ERN10.64083263
101AURKA0.63628346
102MAP3K130.63067468
103MAP3K30.60939582
104TESK10.60569890
105PRKG20.60335410
106TAOK10.60144024
107MAP2K20.58556521
108PTK60.58241091
109SYK0.56575679
110HCK0.55247197
111BMX0.55122805
112MAP2K60.54798517
113LCK0.54670926
114TGFBR20.54122235
115IKBKB0.53563048
116TRPM70.52478712
117MAPKAPK30.51162156
118LYN0.51056264
119TEC0.50766163
120CDK20.49489401
121FES0.49231091
122RPS6KA50.48036135
123TTN0.47666886
124OBSCN0.45020141
125PAK40.44852331
126HIPK20.44826808
127ATM0.43371546
128MAPK110.43319212
129TBK10.42790611
130TYK20.42630704
131CSNK2A10.42542091
132STK240.42116927
133RIPK10.41557274
134MAPK120.41322820
135MELK0.41293828
136IRAK30.40486210
137CSNK2A20.38783412
138BRD40.38414999
139ALK0.36949820
140ZAK0.36720380
141RPS6KL10.36353669
142RPS6KC10.36353669
143CAMK40.36188356
144CHUK0.33999068
145RPS6KA60.33117698
146IRAK40.33025203
147CDK10.32711107

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.58845018
2Mismatch repair_Homo sapiens_hsa034304.26539398
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.69793918
4Spliceosome_Homo sapiens_hsa030403.18767917
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.07129925
6Ribosome_Homo sapiens_hsa030103.06439675
7Base excision repair_Homo sapiens_hsa034102.96445475
8Proteasome_Homo sapiens_hsa030502.89244508
9Retinol metabolism_Homo sapiens_hsa008302.83806918
10Homologous recombination_Homo sapiens_hsa034402.82898045
11Complement and coagulation cascades_Homo sapiens_hsa046102.78423809
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.77341368
13RNA transport_Homo sapiens_hsa030132.57420533
14Chemical carcinogenesis_Homo sapiens_hsa052042.57327562
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.50821638
16Primary bile acid biosynthesis_Homo sapiens_hsa001202.48456348
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.42408763
18Cell cycle_Homo sapiens_hsa041102.37982175
19Nucleotide excision repair_Homo sapiens_hsa034202.37444350
20One carbon pool by folate_Homo sapiens_hsa006702.32818471
21Phenylalanine metabolism_Homo sapiens_hsa003602.30056298
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.29831148
23Arginine biosynthesis_Homo sapiens_hsa002202.28156959
24RNA polymerase_Homo sapiens_hsa030202.24368632
25Fatty acid degradation_Homo sapiens_hsa000712.15429485
26Non-homologous end-joining_Homo sapiens_hsa034502.04574919
27Pyrimidine metabolism_Homo sapiens_hsa002402.02359873
28Pentose and glucuronate interconversions_Homo sapiens_hsa000402.00882048
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.98010360
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.89635019
31Histidine metabolism_Homo sapiens_hsa003401.83629099
32RNA degradation_Homo sapiens_hsa030181.83425680
33Fat digestion and absorption_Homo sapiens_hsa049751.82950351
34Vitamin digestion and absorption_Homo sapiens_hsa049771.76472181
35Fanconi anemia pathway_Homo sapiens_hsa034601.76020972
36Tyrosine metabolism_Homo sapiens_hsa003501.71758454
37Primary immunodeficiency_Homo sapiens_hsa053401.68747494
38Staphylococcus aureus infection_Homo sapiens_hsa051501.65314923
39Starch and sucrose metabolism_Homo sapiens_hsa005001.64121726
40Tryptophan metabolism_Homo sapiens_hsa003801.62879016
41Linoleic acid metabolism_Homo sapiens_hsa005911.56964945
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.54440537
43PPAR signaling pathway_Homo sapiens_hsa033201.53083189
44Other glycan degradation_Homo sapiens_hsa005111.43241972
45Butanoate metabolism_Homo sapiens_hsa006501.38267479
46Epstein-Barr virus infection_Homo sapiens_hsa051691.37439922
47mRNA surveillance pathway_Homo sapiens_hsa030151.34943203
48Basal transcription factors_Homo sapiens_hsa030221.34275136
49Biosynthesis of amino acids_Homo sapiens_hsa012301.33296312
50Bile secretion_Homo sapiens_hsa049761.29689475
51Renin-angiotensin system_Homo sapiens_hsa046141.24542003
52Selenocompound metabolism_Homo sapiens_hsa004501.22804444
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.22565619
54p53 signaling pathway_Homo sapiens_hsa041151.20302696
55Central carbon metabolism in cancer_Homo sapiens_hsa052301.19824051
56Peroxisome_Homo sapiens_hsa041461.18213268
57Pentose phosphate pathway_Homo sapiens_hsa000301.17307696
58Arachidonic acid metabolism_Homo sapiens_hsa005901.16999392
59Acute myeloid leukemia_Homo sapiens_hsa052211.16574119
60B cell receptor signaling pathway_Homo sapiens_hsa046621.14756165
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13344097
62Viral carcinogenesis_Homo sapiens_hsa052031.12078458
63Folate biosynthesis_Homo sapiens_hsa007901.10593513
64Herpes simplex infection_Homo sapiens_hsa051681.05835641
65Cysteine and methionine metabolism_Homo sapiens_hsa002701.05147990
66Purine metabolism_Homo sapiens_hsa002301.04005115
67Fructose and mannose metabolism_Homo sapiens_hsa000511.02548672
68Legionellosis_Homo sapiens_hsa051341.01950910
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98266339
70Antigen processing and presentation_Homo sapiens_hsa046120.92835858
71HTLV-I infection_Homo sapiens_hsa051660.92637532
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90721455
73Carbon metabolism_Homo sapiens_hsa012000.88588604
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87724787
75Pyruvate metabolism_Homo sapiens_hsa006200.87006132
76Measles_Homo sapiens_hsa051620.84851839
77Systemic lupus erythematosus_Homo sapiens_hsa053220.84086692
78Apoptosis_Homo sapiens_hsa042100.83241756
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83018907
80Colorectal cancer_Homo sapiens_hsa052100.82388668
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80963094
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80616103
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.79399468
84Small cell lung cancer_Homo sapiens_hsa052220.77616904
85Hepatitis B_Homo sapiens_hsa051610.71312846
86Chronic myeloid leukemia_Homo sapiens_hsa052200.70578851
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.70403408
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.70035452
89Fatty acid metabolism_Homo sapiens_hsa012120.70033253
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69370565
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68786087
92Sulfur relay system_Homo sapiens_hsa041220.68642565
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67471005
94Arginine and proline metabolism_Homo sapiens_hsa003300.67376590
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65278605
96Prion diseases_Homo sapiens_hsa050200.62468291
97Thyroid cancer_Homo sapiens_hsa052160.61977934
98Influenza A_Homo sapiens_hsa051640.61908558
99Protein export_Homo sapiens_hsa030600.61644423
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61301056
101HIF-1 signaling pathway_Homo sapiens_hsa040660.59784818
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.57716946
103T cell receptor signaling pathway_Homo sapiens_hsa046600.57705863
104Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57041675
105Hematopoietic cell lineage_Homo sapiens_hsa046400.55760601
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55257437
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54611554
108N-Glycan biosynthesis_Homo sapiens_hsa005100.54273843
109NF-kappa B signaling pathway_Homo sapiens_hsa040640.53705788
110Glycerolipid metabolism_Homo sapiens_hsa005610.53248911
111Oocyte meiosis_Homo sapiens_hsa041140.53208990
112Non-small cell lung cancer_Homo sapiens_hsa052230.53129147
113Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51583353
114Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51320592
115Glutathione metabolism_Homo sapiens_hsa004800.50129414
116Pertussis_Homo sapiens_hsa051330.49318988
117Mineral absorption_Homo sapiens_hsa049780.48369826
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48000375
119Insulin resistance_Homo sapiens_hsa049310.47496851
120ABC transporters_Homo sapiens_hsa020100.47061881
121beta-Alanine metabolism_Homo sapiens_hsa004100.46349477
122Pancreatic cancer_Homo sapiens_hsa052120.46001142
123Lysine degradation_Homo sapiens_hsa003100.45704356
124Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44079753
125Intestinal immune network for IgA production_Homo sapiens_hsa046720.42328073
126Leishmaniasis_Homo sapiens_hsa051400.40890929
127Galactose metabolism_Homo sapiens_hsa000520.40132616
128Metabolic pathways_Homo sapiens_hsa011000.40099722
129Glucagon signaling pathway_Homo sapiens_hsa049220.38769349
130Propanoate metabolism_Homo sapiens_hsa006400.38684919
131Vitamin B6 metabolism_Homo sapiens_hsa007500.38638921
132Notch signaling pathway_Homo sapiens_hsa043300.38176365
133Jak-STAT signaling pathway_Homo sapiens_hsa046300.36123524
134Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35299159
135Platelet activation_Homo sapiens_hsa046110.35265754
136Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35059038
137Allograft rejection_Homo sapiens_hsa053300.34527372
138AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34106401
139Osteoclast differentiation_Homo sapiens_hsa043800.33639229
140mTOR signaling pathway_Homo sapiens_hsa041500.32198189
141Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32060904
142RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31954962
143VEGF signaling pathway_Homo sapiens_hsa043700.31697207
144Shigellosis_Homo sapiens_hsa051310.30902756
145Viral myocarditis_Homo sapiens_hsa054160.30902734
146Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30043869
147Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.29523178
148Caffeine metabolism_Homo sapiens_hsa002320.29516043
149Toll-like receptor signaling pathway_Homo sapiens_hsa046200.29187295
150Leukocyte transendothelial migration_Homo sapiens_hsa046700.28402209
151Autoimmune thyroid disease_Homo sapiens_hsa053200.28145305
152Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.26971487
153Toxoplasmosis_Homo sapiens_hsa051450.26100092
154Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25793353
155Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.25620163
156TNF signaling pathway_Homo sapiens_hsa046680.25070138
157Sulfur metabolism_Homo sapiens_hsa009200.23585795
158Fatty acid biosynthesis_Homo sapiens_hsa000610.21646692
159Graft-versus-host disease_Homo sapiens_hsa053320.20161455
160Hepatitis C_Homo sapiens_hsa051600.20093450
161Glycerophospholipid metabolism_Homo sapiens_hsa005640.18652489
162Tuberculosis_Homo sapiens_hsa051520.16232259

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