ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	* vascular endothelial growth factor signaling pathway (GO:0038084)	7.43820736
2	* lymph vessel development (GO:0001945)	7.41067976
3	lymphangiogenesis (GO:0001946)	7.00644974
4	retina vasculature morphogenesis in camera-type eye (GO:0061299)	6.19707525
5	heart valve formation (GO:0003188)	6.10066990
6	* cellular response to vascular endothelial growth factor stimulus (GO:0035924)	6.03735110
7	cell surface receptor signaling pathway involved in heart development (GO:0061311)	5.20080092
8	regulation of endothelial cell differentiation (GO:0045601)	5.00404437
9	positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)	4.99871080
10	patterning of blood vessels (GO:0001569)	4.93924595
11	endothelial tube morphogenesis (GO:0061154)	4.84853182
12	morphogenesis of an endothelium (GO:0003159)	4.84853182
13	blood vessel maturation (GO:0001955)	4.80311513
14	angiogenesis involved in wound healing (GO:0060055)	4.77050960
15	sprouting angiogenesis (GO:0002040)	4.76131339
16	heart trabecula formation (GO:0060347)	4.75734941
17	ovulation from ovarian follicle (GO:0001542)	4.72617545
18	* endothelium development (GO:0003158)	4.65344889
19	endothelial cell morphogenesis (GO:0001886)	4.59559159
20	Notch receptor processing (GO:0007220)	4.55364287
21	transcytosis (GO:0045056)	4.48697667
22	* vascular endothelial growth factor receptor signaling pathway (GO:0048010)	4.47461323
23	labyrinthine layer development (GO:0060711)	4.28500598
24	venous blood vessel morphogenesis (GO:0048845)	4.27863921
25	negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)	4.16424206
26	basement membrane organization (GO:0071711)	4.02701594
27	morphogenesis of an epithelial sheet (GO:0002011)	4.01893672
28	wound healing, spreading of epidermal cells (GO:0035313)	4.01815711
29	positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)	3.96807986
30	positive regulation of lipid kinase activity (GO:0090218)	3.91906768
31	glomerular filtration (GO:0003094)	3.88457624
32	negative regulation of blood vessel endothelial cell migration (GO:0043537)	3.86719877
33	regulation of cell migration involved in sprouting angiogenesis (GO:0090049)	3.85680272
34	aorta morphogenesis (GO:0035909)	3.81528598
35	regulation of establishment or maintenance of cell polarity (GO:0032878)	3.81460172
36	coronary vasculature morphogenesis (GO:0060977)	3.78459276
37	renal filtration (GO:0097205)	3.78246671
38	atrial cardiac muscle cell action potential (GO:0086014)	3.71603672
39	monocyte chemotaxis (GO:0002548)	3.71045916
40	embryonic heart tube development (GO:0035050)	3.67312365
41	* blood vessel endothelial cell migration (GO:0043534)	3.64473594
42	negative regulation of endothelial cell migration (GO:0010596)	3.60254687
43	regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)	3.60186020
44	negative regulation of Rho protein signal transduction (GO:0035024)	3.57923486
45	thrombin receptor signaling pathway (GO:0070493)	3.53586848
46	* endothelial cell differentiation (GO:0045446)	3.50825862
47	glomerular visceral epithelial cell development (GO:0072015)	3.49581756
48	response to hepatocyte growth factor (GO:0035728)	3.48470184
49	cellular response to hepatocyte growth factor stimulus (GO:0035729)	3.48470184
50	endothelial cell chemotaxis (GO:0035767)	3.46702001
51	* positive regulation of vasculogenesis (GO:2001214)	3.44833650
52	* vasculogenesis (GO:0001570)	3.43732881
53	neuron projection extension involved in neuron projection guidance (GO:1902284)	3.37205792
54	axon extension involved in axon guidance (GO:0048846)	3.37205792
55	cardiac ventricle morphogenesis (GO:0003208)	3.36406463
56	* regulation of vasculogenesis (GO:2001212)	3.33777641
57	substrate-dependent cell migration (GO:0006929)	3.31138487
58	positive regulation of protein kinase C signaling (GO:0090037)	3.30049124
59	glomerular basement membrane development (GO:0032836)	3.29934318
60	* cell migration involved in sprouting angiogenesis (GO:0002042)	3.23883106
61	protein localization to endosome (GO:0036010)	3.17978196
62	cell migration involved in heart development (GO:0060973)	3.17159977
63	negative regulation of platelet activation (GO:0010544)	3.15437446
64	Rap protein signal transduction (GO:0032486)	3.12694125
65	ventricular trabecula myocardium morphogenesis (GO:0003222)	3.09851923
66	ganglion development (GO:0061548)	3.09190739
67	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.06664880
68	trabecula formation (GO:0060343)	3.06392175
69	negative regulation of epithelial cell migration (GO:0010633)	3.05814959
70	definitive hemopoiesis (GO:0060216)	3.05772770
71	establishment of endothelial barrier (GO:0061028)	3.05534722
72	* surfactant homeostasis (GO:0043129)	3.05443913
73	glomerular epithelial cell development (GO:0072310)	3.05236709
74	negative regulation of vascular permeability (GO:0043116)	3.04449134
75	bundle of His cell to Purkinje myocyte communication (GO:0086069)	3.03318609
76	cardiac epithelial to mesenchymal transition (GO:0060317)	3.02429600
77	negative regulation of nitric-oxide synthase activity (GO:0051001)	3.02096922
78	cardiac chamber morphogenesis (GO:0003206)	3.01218849
79	Notch signaling involved in heart development (GO:0061314)	3.00725127
80	blood vessel morphogenesis (GO:0048514)	2.99323189
81	regulation of vascular permeability (GO:0043114)	2.98755835
82	neuron remodeling (GO:0016322)	2.98266318
83	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.97864451
84	endocardial cushion morphogenesis (GO:0003203)	2.96979747
85	fatty acid transmembrane transport (GO:1902001)	2.96515636
86	blood vessel remodeling (GO:0001974)	2.95634769
87	cardiac myofibril assembly (GO:0055003)	2.94550310
88	positive regulation of endothelial cell differentiation (GO:0045603)	2.93088547
89	exocrine pancreas development (GO:0031017)	2.90381783
90	negative regulation of adherens junction organization (GO:1903392)	2.90062664
91	negative regulation of focal adhesion assembly (GO:0051895)	2.90062664
92	negative regulation of cell junction assembly (GO:1901889)	2.90062664
93	plasma membrane repair (GO:0001778)	2.88532604
94	regulation of establishment of cell polarity (GO:2000114)	2.87733191
95	dichotomous subdivision of an epithelial terminal unit (GO:0060600)	2.87628821
96	plasma membrane fusion (GO:0045026)	2.87353625
97	embryonic foregut morphogenesis (GO:0048617)	2.86852554
98	* endothelial cell migration (GO:0043542)	2.85621968
99	negative regulation of cell fate specification (GO:0009996)	2.85108975
100	negative regulation of keratinocyte proliferation (GO:0010839)	2.84314751
101	negative regulation of angiogenesis (GO:0016525)	2.84081653
102	* regulation of endothelial cell migration (GO:0010594)	2.83758670
103	heart trabecula morphogenesis (GO:0061384)	2.81479091
104	negative regulation of blood vessel morphogenesis (GO:2000181)	2.80218118
105	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.79804530
106	negative regulation of endothelial cell proliferation (GO:0001937)	2.78376680
107	* regulation of epithelial cell migration (GO:0010632)	2.77932486
108	endothelial cell proliferation (GO:0001935)	2.77434128
109	arginine catabolic process (GO:0006527)	2.74646084
110	trabecula morphogenesis (GO:0061383)	2.74096779
111	* positive regulation of endothelial cell proliferation (GO:0001938)	2.72758574
112	regulation of axon extension involved in axon guidance (GO:0048841)	2.71498891
113	artery development (GO:0060840)	2.70401846
114	ovulation (GO:0030728)	2.67657344
115	negative regulation of vasculature development (GO:1901343)	2.67466034
116	low-density lipoprotein particle clearance (GO:0034383)	2.62264069
117	cardiac muscle cell proliferation (GO:0060038)	2.62120691
118	gap junction assembly (GO:0016264)	2.61206411
119	regulation of blood vessel endothelial cell migration (GO:0043535)	2.59948913
120	regulation of sarcomere organization (GO:0060297)	2.58994308
121	protein kinase C signaling (GO:0070528)	2.56309753
122	* angiogenesis (GO:0001525)	2.56102621
123	regulation of p38MAPK cascade (GO:1900744)	2.55771655
124	* regulation of endothelial cell proliferation (GO:0001936)	2.55124843
125	negative regulation of hemostasis (GO:1900047)	2.53717854
126	negative regulation of blood coagulation (GO:0030195)	2.53717854
127	* positive regulation of endothelial cell migration (GO:0010595)	2.51998020
128	artery morphogenesis (GO:0048844)	2.51628244
129	positive regulation of smooth muscle cell migration (GO:0014911)	2.50147039
130	potassium ion import (GO:0010107)	2.48681914
131	carnitine shuttle (GO:0006853)	2.47804065
132	regulation of sequestering of triglyceride (GO:0010889)	2.46989039
133	semaphorin-plexin signaling pathway (GO:0071526)	2.46821554
134	regulation of axon guidance (GO:1902667)	2.44960084
135	ventricular cardiac muscle tissue morphogenesis (GO:0055010)	2.44258747
136	negative regulation of fibrinolysis (GO:0051918)	2.43365205

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.45859094
2	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	3.75060175
3	TRIM28_21343339_ChIP-Seq_HEK293_Human	3.51466959
4	GATA2_21666600_ChIP-Seq_HMVEC_Human	3.24095321
5	CLOCK_20551151_ChIP-Seq_293T_Human	3.17692676
6	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.84642274
7	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.68156587
8	EP300_21415370_ChIP-Seq_HL-1_Mouse	2.64458873
9	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.60420818
10	SCL_19346495_ChIP-Seq_HPC-7_Human	2.38578749
11	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.30952218
12	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	2.28253468
13	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.25174444
14	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	2.23550009
15	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.19061851
16	VDR_22108803_ChIP-Seq_LS180_Human	2.18410131
17	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	2.13721769
18	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	2.03564995
19	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	2.02274772
20	* ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.96033106
21	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.92912241
22	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.92401584
23	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	1.91982620
24	TBX20_22328084_ChIP-Seq_HEART_Mouse	1.89162889
25	TBX20_22080862_ChIP-Seq_HEART_Mouse	1.89162889
26	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.85539275
27	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.85415884
28	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.83105720
29	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.79735780
30	GATA1_22025678_ChIP-Seq_K562_Human	1.78414661
31	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.77280279
32	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.73842583
33	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.73584083
34	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.71259861
35	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.65515284
36	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.63210270
37	ZNF263_19887448_ChIP-Seq_K562_Human	1.62918493
38	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.62893980
39	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.59845875
40	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.59383962
41	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.56922152
42	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.55312847
43	GATA1_19941826_ChIP-Seq_K562_Human	1.55185860
44	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.52388784
45	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.51596414
46	* SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.49145624
47	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.45385504
48	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.42231541
49	* BRD4_25478319_ChIP-Seq_HGPS_Human	1.41408643
50	* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.39391116
51	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.38797884
52	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.37927763
53	CJUN_26792858_Chip-Seq_BT549_Human	1.37497745
54	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.36926775
55	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.35469582
56	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.33660896
57	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	1.31911678
58	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.31446369
59	YAP1_20516196_ChIP-Seq_MESCs_Mouse	1.30052707
60	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.28874656
61	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.28176432
62	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.28176432
63	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.28176432
64	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.26676322
65	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.26268088
66	AR_21909140_ChIP-Seq_LNCAP_Human	1.26003010
67	LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.24865484
68	RXR_22108803_ChIP-Seq_LS180_Human	1.24481809
69	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.21009531
70	SOX2_20726797_ChIP-Seq_SW620_Human	1.20713116
71	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.19819368
72	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.18837509
73	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.18611411
74	AHR_22903824_ChIP-Seq_MCF-7_Human	1.17623663
75	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.15885684
76	TCF3_18692474_ChIP-Seq_MESCs_Mouse	1.15606653
77	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15550390
78	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.15391145
79	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.14820461
80	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.14375868
81	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.14367080
82	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.12916341
83	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.12342617
84	* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.12200081
85	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.12132780
86	* RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.11813338
87	* EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.11813338
88	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.11446715
89	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.10804209
90	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.10152425
91	TCF3_18692474_ChIP-Seq_MEFs_Mouse	1.07503589
92	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.07410640
93	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.07270175
94	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.07270175
95	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.06681996
96	* MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.04233935
97	GF1_26923725_Chip-Seq_HPCs_Mouse	1.03541787
98	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.02975141
99	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	1.01785330
100	KDM2B_26808549_Chip-Seq_K562_Human	1.01739658
101	* ISL1_27105846_Chip-Seq_CPCs_Mouse	1.00850725
102	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.00022256
103	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.99598984
104	NANOG_18692474_ChIP-Seq_MEFs_Mouse	0.99400332
105	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.98563440
106	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.97722562
107	* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.96556454
108	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.96431482
109	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.96306328
110	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.95944250
111	NANOG_18692474_ChIP-Seq_MESCs_Mouse	0.95854835
112	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	0.95650114
113	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.95108115
114	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.94819680
115	* PRDM14_21183938_ChIP-Seq_MESCs_Mouse	0.94566483
116	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.93678348
117	GATA2_19941826_ChIP-Seq_K562_Human	0.93428099
118	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	0.93057214
119	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.92550865
120	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.92154721
121	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.92090242
122	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.91907911
123	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	0.91576941
124	* SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.91499813
125	* SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.91055935
126	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.90726352
127	FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human	0.90399330
128	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.90309880
129	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.89834664
130	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.89215068
131	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.88586684
132	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.88208169
133	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.88108001
134	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.87393998
135	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.87392122
136	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.86903970
137	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	0.85559131
138	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	0.85559131
139	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.85528934
140	BCAT_22108803_ChIP-Seq_LS180_Human	0.85201786
141	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.83930035
142	DROSHA_22980978_ChIP-Seq_HELA_Human	0.83590825

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010368_abnormal_lymphatic_system	8.16043599
2	* MP0001879_abnormal_lymphatic_vessel	5.58978980
3	MP0005167_abnormal_blood-brain_barrier	4.82459941
4	MP0004084_abnormal_cardiac_muscle	3.73541276
5	* MP0004272_abnormal_basement_membrane	3.55777671
6	MP0003828_pulmonary_edema	3.16622647
7	MP0003724_increased_susceptibility_to	3.10707469
8	MP0000537_abnormal_urethra_morphology	3.06308792
9	MP0006054_spinal_hemorrhage	2.75001724
10	MP0004215_abnormal_myocardial_fiber	2.63695385
11	MP0006138_congestive_heart_failure	2.50099304
12	MP0000013_abnormal_adipose_tissue	2.40152580
13	MP0004036_abnormal_muscle_relaxation	2.38116243
14	MP0009053_abnormal_anal_canal	1.94447796
15	MP0008775_abnormal_heart_ventricle	1.94371713
16	MP0005360_urolithiasis	1.93387828
17	MP0004484_altered_response_of	1.86936149
18	MP0000767_abnormal_smooth_muscle	1.86592958
19	MP0005330_cardiomyopathy	1.85358355
20	MP0002138_abnormal_hepatobiliary_system	1.81055760
21	MP0003279_aneurysm	1.74008880
22	MP0003705_abnormal_hypodermis_morpholog	1.73022457
23	MP0002332_abnormal_exercise_endurance	1.69899430
24	MP0002127_abnormal_cardiovascular_syste	1.68977840
25	MP0003300_gastrointestinal_ulcer	1.67309142
26	MP0004130_abnormal_muscle_cell	1.65132620
27	MP0002972_abnormal_cardiac_muscle	1.61293547
28	MP0002837_dystrophic_cardiac_calcinosis	1.60158055
29	* MP0001544_abnormal_cardiovascular_syste	1.58899595
30	* MP0005385_cardiovascular_system_phenoty	1.58899595
31	MP0005085_abnormal_gallbladder_physiolo	1.57078527
32	MP0005670_abnormal_white_adipose	1.52178374
33	MP0000751_myopathy	1.51716492
34	MP0005595_abnormal_vascular_smooth	1.50152333
35	MP0004147_increased_porphyrin_level	1.49586793
36	* MP0010630_abnormal_cardiac_muscle	1.49426704
37	MP0001849_ear_inflammation	1.48570988
38	* MP0005165_increased_susceptibility_to	1.48033217
39	MP0002128_abnormal_blood_circulation	1.47017797
40	MP0004085_abnormal_heartbeat	1.45750425
41	MP0005623_abnormal_meninges_morphology	1.42273796
42	MP0000516_abnormal_urinary_system	1.40718117
43	MP0005367_renal/urinary_system_phenotyp	1.40718117
44	MP0000249_abnormal_blood_vessel	1.37781350
45	MP0010234_abnormal_vibrissa_follicle	1.35716434
46	MP0005620_abnormal_muscle_contractility	1.35657952
47	MP0003191_abnormal_cellular_cholesterol	1.32018233
48	MP0009278_abnormal_bone_marrow	1.31442205
49	MP0005365_abnormal_bile_salt	1.31262247
50	* MP0002925_abnormal_cardiovascular_devel	1.29379053
51	MP0002877_abnormal_melanocyte_morpholog	1.28645888
52	MP0003315_abnormal_perineum_morphology	1.24146862
53	MP0002139_abnormal_hepatobiliary_system	1.22447779
54	MP0003566_abnormal_cell_adhesion	1.22367923
55	MP0008004_abnormal_stomach_pH	1.21049323
56	MP0002295_abnormal_pulmonary_circulatio	1.20140826
57	* MP0001614_abnormal_blood_vessel	1.18572000
58	MP0000343_altered_response_to	1.18202731
59	MP0009697_abnormal_copulation	1.13600723
60	MP0000230_abnormal_systemic_arterial	1.13206495
61	MP0003303_peritoneal_inflammation	1.11161896
62	MP0003252_abnormal_bile_duct	1.10755663
63	* MP0005380_embryogenesis_phenotype	1.09110317
64	* MP0001672_abnormal_embryogenesis/_devel	1.09110317
65	MP0004087_abnormal_muscle_fiber	1.08138027
66	MP0002697_abnormal_eye_size	1.06397092
67	MP0010329_abnormal_lipoprotein_level	1.05378117
68	MP0000003_abnormal_adipose_tissue	1.05286013
69	MP0001730_embryonic_growth_arrest	1.04840582
70	MP0001915_intracranial_hemorrhage	1.04737653
71	* MP0000266_abnormal_heart_morphology	1.02914650
72	MP0010030_abnormal_orbit_morphology	1.02304641
73	MP0004885_abnormal_endolymph	1.00906988
74	MP0003941_abnormal_skin_development	0.98792444
75	MP0005084_abnormal_gallbladder_morpholo	0.97740584
76	MP0005409_darkened_coat_color	0.96066152
77	MP0003935_abnormal_craniofacial_develop	0.93361465
78	MP0003119_abnormal_digestive_system	0.93212408
79	MP0000750_abnormal_muscle_regeneration	0.92296136
80	* MP0002084_abnormal_developmental_patter	0.91925502
81	MP0008875_abnormal_xenobiotic_pharmacok	0.90009400
82	MP0005164_abnormal_response_to	0.88980078
83	MP0001784_abnormal_fluid_regulation	0.87136388
84	MP0010352_gastrointestinal_tract_polyps	0.86939729
85	MP0001958_emphysema	0.86646014
86	MP0000749_muscle_degeneration	0.84895914
87	MP0005375_adipose_tissue_phenotype	0.84747572
88	MP0004883_abnormal_blood_vessel	0.84004022
89	MP0005666_abnormal_adipose_tissue	0.83512435
90	MP0004510_myositis	0.82890221
91	MP0003091_abnormal_cell_migration	0.82812518
92	MP0009379_abnormal_foot_pigmentation	0.80598336
93	MP0003950_abnormal_plasma_membrane	0.79274062
94	MP0008438_abnormal_cutaneous_collagen	0.78986487
95	MP0005197_abnormal_uvea_morphology	0.78136334
96	MP0004782_abnormal_surfactant_physiolog	0.77209605
97	MP0005187_abnormal_penis_morphology	0.75232667
98	* MP0005193_abnormal_anterior_eye	0.73832851
99	MP0009643_abnormal_urine_homeostasis	0.73461576
100	MP0001851_eye_inflammation	0.69637634
101	MP0000465_gastrointestinal_hemorrhage	0.69610233
102	MP0009780_abnormal_chondrocyte_physiolo	0.69371078
103	* MP0003943_abnormal_hepatobiliary_system	0.66930531
104	MP0003122_maternal_imprinting	0.66274628
105	MP0005319_abnormal_enzyme/_coenzyme	0.65924528
106	MP0001756_abnormal_urination	0.65629401
107	MP0002133_abnormal_respiratory_system	0.63073457
108	MP0005388_respiratory_system_phenotype	0.63073457
109	MP0000609_abnormal_liver_physiology	0.62722357
110	MP0002088_abnormal_embryonic_growth/wei	0.61827132
111	MP0003137_abnormal_impulse_conducting	0.61718867
112	MP0002092_abnormal_eye_morphology	0.59999160
113	MP0003984_embryonic_growth_retardation	0.59529506
114	MP0002118_abnormal_lipid_homeostasis	0.59217659
115	MP0002933_joint_inflammation	0.58875499
116	MP0002896_abnormal_bone_mineralization	0.58340415
117	MP0004185_abnormal_adipocyte_glucose	0.58270693
118	* MP0002080_prenatal_lethality	0.57723857
119	MP0003567_abnormal_fetal_cardiomyocyte	0.57293367
120	MP0002106_abnormal_muscle_physiology	0.56682963
121	* MP0002086_abnormal_extraembryonic_tissu	0.56645230
122	MP0005332_abnormal_amino_acid	0.56337310
123	* MP0002085_abnormal_embryonic_tissue	0.54790218
124	MP0005248_abnormal_Harderian_gland	0.51841539
125	MP0009672_abnormal_birth_weight	0.51503508
126	MP0002108_abnormal_muscle_morphology	0.50889787
127	MP0005083_abnormal_biliary_tract	0.50237526
128	MP0005369_muscle_phenotype	0.49871449
129	MP0005058_abnormal_lysosome_morphology	0.49240095
130	MP0003385_abnormal_body_wall	0.45149185
131	MP0003937_abnormal_limbs/digits/tail_de	0.44640518
132	* MP0001697_abnormal_embryo_size	0.43823503
133	MP0000733_abnormal_muscle_development	0.43057691
134	MP0005501_abnormal_skin_physiology	0.42915255
135	MP0004808_abnormal_hematopoietic_stem	0.40766482
136	MP0001191_abnormal_skin_condition	0.39929808
137	MP0002254_reproductive_system_inflammat	0.39176585
138	MP0000428_abnormal_craniofacial_morphol	0.38353220

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Polycythemia (HP:0001901)	6.25720184
2	Esophageal varix (HP:0002040)	5.41322036
3	Hematochezia (HP:0002573)	5.37885796
4	Nonimmune hydrops fetalis (HP:0001790)	5.24592146
5	Spontaneous hematomas (HP:0007420)	5.17820821
6	Deep venous thrombosis (HP:0002625)	4.44318391
7	Lymphangioma (HP:0100764)	4.43393810
8	Ventricular tachycardia (HP:0004756)	4.02909147
9	Hypoglycemic coma (HP:0001325)	3.90115523
10	Muscle fiber splitting (HP:0003555)	3.88555184
11	Cerebral hemorrhage (HP:0001342)	3.87717317
12	Sudden death (HP:0001699)	3.70184553
13	Scotoma (HP:0000575)	3.62258938
14	Limb dystonia (HP:0002451)	3.60690943
15	Broad metatarsal (HP:0001783)	3.59466939
16	Arterial tortuosity (HP:0005116)	3.48608717
17	Conjunctival telangiectasia (HP:0000524)	3.44802979
18	Visceral angiomatosis (HP:0100761)	3.43550862
19	Adactyly (HP:0009776)	3.43198387
20	Myotonia (HP:0002486)	3.34541013
21	Cerebral aneurysm (HP:0004944)	3.33445735
22	Portal hypertension (HP:0001409)	3.29420508
23	Hemangiomatosis (HP:0007461)	3.28005145
24	Premature rupture of membranes (HP:0001788)	3.27319411
25	Hemorrhage of the eye (HP:0011885)	3.25772076
26	Hypopigmentation of the fundus (HP:0007894)	3.25282767
27	Atrial fibrillation (HP:0005110)	3.24668677
28	Hyporeflexia of lower limbs (HP:0002600)	3.24598992
29	Amblyopia (HP:0000646)	3.23349932
30	Increased connective tissue (HP:0009025)	3.23148283
31	Areflexia of lower limbs (HP:0002522)	3.18564104
32	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	3.16898661
33	Short 4th metacarpal (HP:0010044)	3.16898661
34	Absent hand (HP:0004050)	3.15161211
35	Abnormality of the nasal mucosa (HP:0000433)	3.10628600
36	Supraventricular arrhythmia (HP:0005115)	3.07101595
37	Vascular tortuosity (HP:0004948)	3.00812749
38	Long clavicles (HP:0000890)	2.99307639
39	Primary atrial arrhythmia (HP:0001692)	2.95949947
40	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.95526267
41	Abnormality of the hepatic vasculature (HP:0006707)	2.92354258
42	Hyperinsulinemic hypoglycemia (HP:0000825)	2.90988022
43	Exotropia (HP:0000577)	2.90610517
44	Difficulty running (HP:0009046)	2.89108650
45	Cavernous hemangioma (HP:0001048)	2.87002257
46	Right ventricular cardiomyopathy (HP:0011663)	2.86804350
47	Skull defect (HP:0001362)	2.82750130
48	Pigmentary retinal degeneration (HP:0001146)	2.82424565
49	Porencephaly (HP:0002132)	2.80039348
50	Exercise-induced muscle cramps (HP:0003710)	2.79056312
51	Supraventricular tachycardia (HP:0004755)	2.77820664
52	Joint hemorrhage (HP:0005261)	2.76666914
53	Hypoglycemic seizures (HP:0002173)	2.74011156
54	Mesangial abnormality (HP:0001966)	2.73577966
55	Myocardial infarction (HP:0001658)	2.72350459
56	Protrusio acetabuli (HP:0003179)	2.71226044
57	Lipoatrophy (HP:0100578)	2.68997799
58	Thin ribs (HP:0000883)	2.68318498
59	Pancreatic islet-cell hyperplasia (HP:0004510)	2.67575048
60	* Capillary hemangiomas (HP:0005306)	2.66577306
61	Abnormality of the intrinsic pathway (HP:0010989)	2.63292789
62	Venous insufficiency (HP:0005293)	2.60446755
63	Aneurysm (HP:0002617)	2.60196514
64	Short hallux (HP:0010109)	2.56166838
65	Spastic diplegia (HP:0001264)	2.53643309
66	Subacute progressive viral hepatitis (HP:0006572)	2.52466303
67	Hypoalphalipoproteinemia (HP:0003233)	2.47520399
68	Intrahepatic cholestasis (HP:0001406)	2.44427011
69	Short palpebral fissure (HP:0012745)	2.42478902
70	Congenital, generalized hypertrichosis (HP:0004540)	2.41683042
71	Shallow orbits (HP:0000586)	2.41572671
72	Stroke (HP:0001297)	2.41145090
73	Syncope (HP:0001279)	2.40799788
74	Aplasia cutis congenita (HP:0001057)	2.38958365
75	Wrist flexion contracture (HP:0001239)	2.38499446
76	Ketoacidosis (HP:0001993)	2.38365907
77	Venous abnormality (HP:0002624)	2.37591328
78	Hemiparesis (HP:0001269)	2.36288055
79	Cutaneous syndactyly (HP:0012725)	2.35702920
80	Atrioventricular block (HP:0001678)	2.33983981
81	Hypoplastic ischia (HP:0003175)	2.33922493
82	Aplasia/Hypoplasia of the hallux (HP:0008362)	2.32714827
83	Overgrowth (HP:0001548)	2.32701502
84	Mucosal telangiectasiae (HP:0100579)	2.30649409
85	Abnormality of the ischium (HP:0003174)	2.30097420
86	Cutaneous finger syndactyly (HP:0010554)	2.29066694
87	Lymphedema (HP:0001004)	2.24871439
88	High pitched voice (HP:0001620)	2.21899801
89	Bilateral sensorineural hearing impairment (HP:0008619)	2.17183797
90	Dilated cardiomyopathy (HP:0001644)	2.14024427
91	Aortic aneurysm (HP:0004942)	2.13663251
92	Abnormality of pain sensation (HP:0010832)	2.12208426
93	Impaired pain sensation (HP:0007328)	2.12208426
94	Hypoplasia of the iris (HP:0007676)	2.12129338
95	Hyperlipoproteinemia (HP:0010980)	2.12119988
96	Increased variability in muscle fiber diameter (HP:0003557)	2.12104148
97	Prolonged partial thromboplastin time (HP:0003645)	2.11971748
98	Absent eyebrow (HP:0002223)	2.11569549
99	Myoglobinuria (HP:0002913)	2.11298632
100	Congenital cataract (HP:0000519)	2.10971398
101	Xanthomatosis (HP:0000991)	2.09347839
102	Abnormality of the 4th metacarpal (HP:0010012)	2.09246455
103	Vitreoretinal degeneration (HP:0000655)	2.08201400
104	Dysautonomia (HP:0002459)	2.06678620
105	Pulmonary embolism (HP:0002204)	2.05986927
106	Focal segmental glomerulosclerosis (HP:0000097)	2.05334789
107	Cardiovascular calcification (HP:0011915)	2.03851209
108	Ketosis (HP:0001946)	2.03365327
109	Vertebral clefting (HP:0008428)	2.03020509
110	Chondrocalcinosis (HP:0000934)	2.02500843
111	Short tibia (HP:0005736)	2.01958675
112	Growth hormone excess (HP:0000845)	2.01918627
113	Absent toe (HP:0010760)	2.01350928
114	Prolonged QT interval (HP:0001657)	2.00992997
115	Anteriorly placed anus (HP:0001545)	2.00537938
116	Abnormality of the vitreous humor (HP:0004327)	1.99090708
117	Pulmonary hypertension (HP:0002092)	1.98743093
118	Absent eyelashes (HP:0000561)	1.97057729
119	Neonatal death (HP:0003811)	1.96748357
120	Disproportionate tall stature (HP:0001519)	1.95983690
121	Calf muscle hypertrophy (HP:0008981)	1.95866069
122	Anterior segment dysgenesis (HP:0007700)	1.95529997
123	Vascular calcification (HP:0004934)	1.95271433
124	Joint contractures involving the joints of the feet (HP:0100492)	1.95210366
125	Flexion contracture of toe (HP:0005830)	1.95210366
126	Pulmonary artery stenosis (HP:0004415)	1.95199058
127	EMG: myopathic abnormalities (HP:0003458)	1.95108782
128	Abnormality of the common coagulation pathway (HP:0010990)	1.94234507
129	Complement deficiency (HP:0004431)	1.93627986
130	Generalized hypotonia (HP:0001290)	1.93410382
131	Tetraparesis (HP:0002273)	1.92978949
132	Abnormality of the pancreatic islet cells (HP:0006476)	1.91579908
133	Abnormality of endocrine pancreas physiology (HP:0012093)	1.91579908
134	Spinal rigidity (HP:0003306)	1.90701013
135	Cortical dysplasia (HP:0002539)	1.90595889
136	Heart block (HP:0012722)	1.90570044
137	Abnormal vertebral ossification (HP:0100569)	1.90215875
138	Exercise-induced myalgia (HP:0003738)	1.89476546
139	Hemiplegia (HP:0002301)	1.88255170
140	Thrombophlebitis (HP:0004418)	1.88166898
141	Camptodactyly of toe (HP:0001836)	1.87821644
142	Aortic dissection (HP:0002647)	1.87588934
143	Abnormality of Sharpey fibers (HP:0100685)	1.86479358
144	Delayed CNS myelination (HP:0002188)	1.85636405
145	Abnormality of skeletal muscle fiber size (HP:0012084)	1.85249196
146	Hyperammonemia (HP:0001987)	1.84624145
147	Difficulty climbing stairs (HP:0003551)	1.84275165
148	Large for gestational age (HP:0001520)	1.82515167
149	Bicuspid aortic valve (HP:0001647)	1.81669346
150	Hereditary nonpolyposis colorectal carcinoma (HP:0006716)	1.79759574
151	Broad ribs (HP:0000885)	1.79273504
152	Centrally nucleated skeletal muscle fibers (HP:0003687)	1.77434578
153	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.77300435
154	Abnormal atrioventricular conduction (HP:0005150)	1.76381783
155	Asymmetry of the thorax (HP:0001555)	1.74708409
156	Hydroureter (HP:0000072)	1.72612790
157	Aplasia involving bones of the upper limbs (HP:0009823)	1.72567094
158	Aplasia of the phalanges of the hand (HP:0009802)	1.72567094
159	Aplasia involving bones of the extremities (HP:0009825)	1.72567094
160	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.72413647

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	* KDR	5.70618928
2	TGFBR2	3.92008553
3	TGFBR1	2.87105039
4	GRK1	2.11235556
5	EPHB2	2.07269110
6	RIPK1	2.00850312
7	TIE1	11.7438407
8	INSRR	1.98895801
9	PTK2B	1.82484587
10	NTRK1	1.56122191
11	ERN1	1.56068433
12	MYLK	1.46277002
13	PTK6	1.29467925
14	TTN	1.29171791
15	PDK2	1.28111617
16	PKN2	1.19569521
17	PDGFRA	1.16143824
18	WNK4	1.12628834
19	FER	1.10363297
20	FGFR4	1.06169796
21	TRIB3	1.04911622
22	DMPK	1.04116789
23	EPHB1	1.00349418
24	MAPK12	0.99492882
25	PRKG2	0.98831693
26	MAP2K3	0.95126480
27	EEF2K	0.93767778
28	SIK1	0.91041180
29	PRKD1	0.85236883
30	BCKDK	0.79685587
31	TYRO3	0.78891339
32	PRKAA2	0.76790945
33	FGFR2	0.75168426
34	OBSCN	0.75125149
35	MAPK15	0.74141559
36	CAMK1D	0.70442485
37	SCYL2	0.69407612
38	CAMK1G	0.68843336
39	YES1	0.66991226
40	PAK4	0.66245279
41	PTK2	0.65714365
42	LATS2	0.64626832
43	PRKCH	0.64617770
44	LATS1	0.63493822
45	STK39	0.62927180
46	AKT3	0.62381248
47	JAK1	0.61813834
48	MAP3K3	0.61319889
49	FGFR3	0.61019121
50	LMTK2	0.60802688
51	TSSK6	0.59460336
52	MAPK7	0.57330281
53	LRRK2	0.57308338
54	TEC	0.56750594
55	CAMK4	0.55996759
56	CSK	0.55647762
57	MAP2K2	0.54688272
58	GSK3A	0.53130771
59	PHKG1	0.51672282
60	PHKG2	0.51672282
61	MET	0.49548974
62	CSNK1G1	0.49052382
63	ROCK2	0.48935167
64	ARAF	0.48044680
65	MOS	0.46933228
66	TRPM7	0.46838870
67	JAK2	0.46305100
68	PDGFRB	0.45449735
69	PRKD3	0.43764046
70	RET	0.43346568
71	ZAP70	0.42455363
72	MAP3K1	0.41974158
73	PDK3	0.41231771
74	PDK4	0.41231771
75	BCR	0.39975178
76	MAP2K1	0.39762551
77	NEK9	0.39420043
78	CDK6	0.39257509
79	MAP3K13	0.38631340
80	PRKAA1	0.37418066
81	PLK2	0.37097588
82	PDPK1	0.36360058
83	MAP3K7	0.36229662
84	ERBB4	0.35439776
85	NLK	0.35303936
86	* IGF1R	0.35284306
87	MARK3	0.34929832
88	MAP3K9	0.33921118
89	PRKCE	0.33823989
90	PLK4	0.33785122
91	ROCK1	0.33667468
92	JAK3	0.32915734
93	PIK3CA	0.32206635
94	TYK2	0.31526449
95	ITK	0.30869499
96	* SRC	0.30739178
97	CDK9	0.30229124
98	STK10	0.29879114
99	INSR	0.29398491
100	RPS6KA2	0.27922094
101	TAF1	0.27559038
102	MAP3K10	0.27259796
103	MARK2	0.26742830
104	PAK2	0.26328001
105	PAK3	0.26303011
106	BMPR1B	0.25481979
107	FRK	0.24723371
108	PRKD2	0.23919230
109	MAPK10	0.22077359
110	FGFR1	0.21331408
111	MKNK2	0.21027598
112	CSNK1A1L	0.20549770
113	NUAK1	0.20202549
114	FLT3	0.18675381
115	EPHA3	0.18583523
116	TBK1	0.18531256
117	TNIK	0.18411929
118	MTOR	0.18338216
119	PLK3	0.17926848
120	CSNK1G3	0.17882090
121	SGK2	0.17791908
122	GRK5	0.17705015
123	* EGFR	0.17670591
124	AKT2	0.17530632
125	SGK3	0.17028924
126	PRKACB	0.16431428
127	MAPK4	0.16130747
128	KIT	0.15878405
129	PRKACG	0.15656704
130	MAP3K8	0.14662204
131	MAP3K11	0.14577017
132	FES	0.14373324
133	BMX	0.14095286
134	MAPKAPK3	0.14044491
135	HCK	0.12595266
136	KSR2	0.11872551
137	FGR	0.10965248
138	WEE1	0.10477202
139	CSNK1G2	0.10065107
140	MAPK9	0.08890199
141	SMG1	0.08705901
142	MAP3K12	0.07998328
143	MKNK1	0.07717077
144	SGK494	0.07307831
145	SGK223	0.07307831
146	MAP3K6	0.06826866

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Arginine biosynthesis_Homo sapiens_hsa00220	2.53962033
2	Fatty acid degradation_Homo sapiens_hsa00071	2.46179214
3	Complement and coagulation cascades_Homo sapiens_hsa04610	2.41960269
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.34445474
5	PPAR signaling pathway_Homo sapiens_hsa03320	2.10653486
6	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.07380025
7	Adherens junction_Homo sapiens_hsa04520	2.05875392
8	ECM-receptor interaction_Homo sapiens_hsa04512	2.03145329
9	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.02307449
10	Propanoate metabolism_Homo sapiens_hsa00640	2.01334719
11	Bile secretion_Homo sapiens_hsa04976	1.94977672
12	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.88823360
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.88681177
14	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.86424659
15	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.84517405
16	* Focal adhesion_Homo sapiens_hsa04510	1.79834331
17	Fatty acid metabolism_Homo sapiens_hsa01212	1.78751485
18	Steroid biosynthesis_Homo sapiens_hsa00100	1.64060732
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.63373725
20	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.63228032
21	Thyroid cancer_Homo sapiens_hsa05216	1.63187088
22	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.61279975
23	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.59014251
24	Leukocyte transendothelial migration_Homo sapiens_hsa04670	1.52953062
25	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.52780601
26	Prion diseases_Homo sapiens_hsa05020	1.47182499
27	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.46888420
28	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.39849708
29	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.37094979
30	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.32273821
31	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.30673423
32	ABC transporters_Homo sapiens_hsa02010	1.26341066
33	MicroRNAs in cancer_Homo sapiens_hsa05206	1.26189608
34	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.26143765
35	Insulin resistance_Homo sapiens_hsa04931	1.25855772
36	Caffeine metabolism_Homo sapiens_hsa00232	1.21717551
37	Notch signaling pathway_Homo sapiens_hsa04330	1.18742704
38	* Rap1 signaling pathway_Homo sapiens_hsa04015	1.17882268
39	Butanoate metabolism_Homo sapiens_hsa00650	1.13964497
40	Small cell lung cancer_Homo sapiens_hsa05222	1.11764914
41	Pancreatic cancer_Homo sapiens_hsa05212	1.11306810
42	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.10868558
43	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.08689566
44	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.08593096
45	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.05994025
46	* Endocytosis_Homo sapiens_hsa04144	1.03841403
47	Amoebiasis_Homo sapiens_hsa05146	1.03546192
48	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.03328847
49	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.02168420
50	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.01886022
51	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.01647136
52	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.97565396
53	Fat digestion and absorption_Homo sapiens_hsa04975	0.96153937
54	Protein digestion and absorption_Homo sapiens_hsa04974	0.96121440
55	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.95773696
56	beta-Alanine metabolism_Homo sapiens_hsa00410	0.95747720
57	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.92322912
58	Peroxisome_Homo sapiens_hsa04146	0.91852005
59	Hippo signaling pathway_Homo sapiens_hsa04390	0.91709470
60	Tight junction_Homo sapiens_hsa04530	0.90135076
61	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.89097772
62	* PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.88827115
63	Lysine degradation_Homo sapiens_hsa00310	0.87635626
64	African trypanosomiasis_Homo sapiens_hsa05143	0.87051877
65	Malaria_Homo sapiens_hsa05144	0.86576212
66	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.85506412
67	Prostate cancer_Homo sapiens_hsa05215	0.85229566
68	Platelet activation_Homo sapiens_hsa04611	0.84672706
69	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.84672660
70	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.82809321
71	Viral myocarditis_Homo sapiens_hsa05416	0.82629375
72	Colorectal cancer_Homo sapiens_hsa05210	0.81302776
73	Fatty acid elongation_Homo sapiens_hsa00062	0.80782986
74	Shigellosis_Homo sapiens_hsa05131	0.80738526
75	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.80681112
76	Axon guidance_Homo sapiens_hsa04360	0.79462981
77	Renal cell carcinoma_Homo sapiens_hsa05211	0.78251990
78	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.77588261
79	Renin-angiotensin system_Homo sapiens_hsa04614	0.75173166
80	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.74835853
81	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.73931819
82	Basal cell carcinoma_Homo sapiens_hsa05217	0.73884806
83	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.73781223
84	Renin secretion_Homo sapiens_hsa04924	0.72919865
85	* Proteoglycans in cancer_Homo sapiens_hsa05205	0.72243825
86	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.72069335
87	Endometrial cancer_Homo sapiens_hsa05213	0.71821274
88	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.71331811
89	Bladder cancer_Homo sapiens_hsa05219	0.69734544
90	Pyruvate metabolism_Homo sapiens_hsa00620	0.68383753
91	Melanogenesis_Homo sapiens_hsa04916	0.68123905
92	Phenylalanine metabolism_Homo sapiens_hsa00360	0.67375846
93	Carbon metabolism_Homo sapiens_hsa01200	0.66604126
94	Arginine and proline metabolism_Homo sapiens_hsa00330	0.65231487
95	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.64985129
96	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.64796377
97	Glioma_Homo sapiens_hsa05214	0.64629827
98	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.63994165
99	* VEGF signaling pathway_Homo sapiens_hsa04370	0.61250803
100	Toxoplasmosis_Homo sapiens_hsa05145	0.59726153
101	* Ras signaling pathway_Homo sapiens_hsa04014	0.58418653
102	AMPK signaling pathway_Homo sapiens_hsa04152	0.57467748
103	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.56999080
104	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.56215191
105	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.55410607
106	Pathways in cancer_Homo sapiens_hsa05200	0.55007226
107	Glucagon signaling pathway_Homo sapiens_hsa04922	0.54802024
108	Cardiac muscle contraction_Homo sapiens_hsa04260	0.53550715
109	Salmonella infection_Homo sapiens_hsa05132	0.52478351
110	Melanoma_Homo sapiens_hsa05218	0.52217970
111	Histidine metabolism_Homo sapiens_hsa00340	0.50184852
112	Wnt signaling pathway_Homo sapiens_hsa04310	0.49328256
113	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.48988893
114	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.48537862
115	Choline metabolism in cancer_Homo sapiens_hsa05231	0.48430787
116	Tyrosine metabolism_Homo sapiens_hsa00350	0.48375772
117	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.46841842
118	Glycerolipid metabolism_Homo sapiens_hsa00561	0.46541568
119	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.45779181
120	Rheumatoid arthritis_Homo sapiens_hsa05323	0.45294894
121	Retinol metabolism_Homo sapiens_hsa00830	0.45242795
122	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.44884060
123	cAMP signaling pathway_Homo sapiens_hsa04024	0.43924913
124	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.43833901
125	Gap junction_Homo sapiens_hsa04540	0.43790197
126	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.43278606
127	Chemical carcinogenesis_Homo sapiens_hsa05204	0.43267132
128	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.42541306
129	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.42141387
130	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.39952345
131	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.39781422
132	Estrogen signaling pathway_Homo sapiens_hsa04915	0.39307703
133	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.38670929
134	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.36906277
135	Gastric acid secretion_Homo sapiens_hsa04971	0.36251814
136	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.35813327
137	Pancreatic secretion_Homo sapiens_hsa04972	0.35734858
138	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.35228847
139	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.35017357
140	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.34906667
141	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.31589350
142	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.30389422
143	Insulin signaling pathway_Homo sapiens_hsa04910	0.28230418
144	GnRH signaling pathway_Homo sapiens_hsa04912	0.25284463
145	MAPK signaling pathway_Homo sapiens_hsa04010	0.25250242
146	Vibrio cholerae infection_Homo sapiens_hsa05110	0.24610605
147	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.23963819
148	Selenocompound metabolism_Homo sapiens_hsa00450	0.23177607
149	* Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.21358453
150	FoxO signaling pathway_Homo sapiens_hsa04068	0.19176732
151	Other glycan degradation_Homo sapiens_hsa00511	0.19125853
152	Sphingolipid metabolism_Homo sapiens_hsa00600	0.17626861
153	ErbB signaling pathway_Homo sapiens_hsa04012	0.16772944

KDR

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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