KEAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.96838039
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.91553528
3L-phenylalanine metabolic process (GO:0006558)4.91553528
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.83575160
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.83575160
6L-phenylalanine catabolic process (GO:0006559)4.70343617
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.70343617
8NADH metabolic process (GO:0006734)4.65341980
9alpha-linolenic acid metabolic process (GO:0036109)4.52237518
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.51158259
11proline biosynthetic process (GO:0006561)4.49389520
12fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.17783012
132-oxoglutarate metabolic process (GO:0006103)4.16479658
14protein retention in ER lumen (GO:0006621)4.13077825
15antigen processing and presentation of endogenous antigen (GO:0019883)4.09324900
16maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.04390155
17protein maturation by protein folding (GO:0022417)4.03103879
18lysine metabolic process (GO:0006553)3.93793455
19lysine catabolic process (GO:0006554)3.93793455
20pentose-phosphate shunt (GO:0006098)3.85914388
21valine metabolic process (GO:0006573)3.85274286
22kynurenine metabolic process (GO:0070189)3.84034788
234-hydroxyproline metabolic process (GO:0019471)3.79009107
24sulfur amino acid catabolic process (GO:0000098)3.78596739
25protein carboxylation (GO:0018214)3.78583350
26peptidyl-glutamic acid carboxylation (GO:0017187)3.78583350
27aromatic amino acid family catabolic process (GO:0009074)3.78060970
28barbed-end actin filament capping (GO:0051016)3.77086389
29glyoxylate metabolic process (GO:0046487)3.73112707
30regulation of cholesterol homeostasis (GO:2000188)3.72941402
31retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.63752986
32high-density lipoprotein particle remodeling (GO:0034375)3.61913450
33negative regulation of fibrinolysis (GO:0051918)3.60383946
34urea cycle (GO:0000050)3.60117091
35urea metabolic process (GO:0019627)3.60117091
36protein localization to endosome (GO:0036010)3.58098097
37pinocytosis (GO:0006907)3.56328930
38plasma lipoprotein particle clearance (GO:0034381)3.55779383
39regulation of fatty acid beta-oxidation (GO:0031998)3.52434299
40regulation of triglyceride catabolic process (GO:0010896)3.52190669
41tricarboxylic acid metabolic process (GO:0072350)3.51722536
42peptidyl-arginine omega-N-methylation (GO:0035247)3.51408024
43cysteine metabolic process (GO:0006534)3.49880585
44bile acid biosynthetic process (GO:0006699)3.49314667
45nucleotide salvage (GO:0043173)3.47410514
46oxaloacetate metabolic process (GO:0006107)3.46263438
47fatty acid beta-oxidation (GO:0006635)3.44862011
48NADPH regeneration (GO:0006740)3.41102978
49positive regulation of triglyceride biosynthetic process (GO:0010867)3.39926782
50nitrogen cycle metabolic process (GO:0071941)3.37998438
51positive regulation of triglyceride metabolic process (GO:0090208)3.35847878
52glucose catabolic process (GO:0006007)3.32210266
53complement activation, alternative pathway (GO:0006957)3.31918587
54negative regulation of sterol transport (GO:0032372)3.29127646
55negative regulation of cholesterol transport (GO:0032375)3.29127646
56short-chain fatty acid metabolic process (GO:0046459)3.28812500
57aspartate family amino acid catabolic process (GO:0009068)3.24382735
58fatty acid catabolic process (GO:0009062)3.24273586
59UV protection (GO:0009650)3.23253585
60cellular ketone body metabolic process (GO:0046950)3.23209396
61regulation of fatty acid oxidation (GO:0046320)3.22801313
62purine nucleotide salvage (GO:0032261)3.21982407
63fatty acid oxidation (GO:0019395)3.21862054
64phospholipid efflux (GO:0033700)3.21567438
65negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.21125897
66amino-acid betaine metabolic process (GO:0006577)3.20366070
67monosaccharide biosynthetic process (GO:0046364)3.19986707
68regulation of fibrinolysis (GO:0051917)3.17112340
69cellular modified amino acid catabolic process (GO:0042219)3.16589279
70positive regulation of fatty acid beta-oxidation (GO:0032000)3.15032559
71gluconeogenesis (GO:0006094)3.14646294
72reverse cholesterol transport (GO:0043691)3.14229500
73lipid oxidation (GO:0034440)3.13628176
74mitochondrial fusion (GO:0008053)3.10969211
75deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.10249262
76regulation of protein activation cascade (GO:2000257)3.10215113
77monocarboxylic acid catabolic process (GO:0072329)3.09878636
78endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.09589557
79Golgi transport vesicle coating (GO:0048200)3.09190269
80COPI coating of Golgi vesicle (GO:0048205)3.09190269
81regulation of mammary gland epithelial cell proliferation (GO:0033599)3.07866786
82tryptophan catabolic process (GO:0006569)3.06475182
83indole-containing compound catabolic process (GO:0042436)3.06475182
84indolalkylamine catabolic process (GO:0046218)3.06475182
85positive regulation of lipid catabolic process (GO:0050996)3.06012090
86plasma lipoprotein particle remodeling (GO:0034369)3.04481207
87protein-lipid complex remodeling (GO:0034368)3.04481207
88macromolecular complex remodeling (GO:0034367)3.04481207
89regulation of cholesterol esterification (GO:0010872)3.04403821
90low-density lipoprotein particle clearance (GO:0034383)3.04042198
91negative regulation of cell size (GO:0045792)3.03884967
92triglyceride homeostasis (GO:0070328)3.03087105
93acylglycerol homeostasis (GO:0055090)3.03087105
94dicarboxylic acid biosynthetic process (GO:0043650)3.01792363
95nucleobase-containing small molecule interconversion (GO:0015949)2.99398953
96positive regulation of histone deacetylation (GO:0031065)2.99361591
97homocysteine metabolic process (GO:0050667)2.98664220
98spliceosomal tri-snRNP complex assembly (GO:0000244)2.98660848
99creatine metabolic process (GO:0006600)2.98499629
100acetyl-CoA metabolic process (GO:0006084)2.96875742
101nuclear envelope reassembly (GO:0031468)2.96843754
102mitotic nuclear envelope reassembly (GO:0007084)2.96843754
103hexose biosynthetic process (GO:0019319)2.95989464
104proline metabolic process (GO:0006560)2.95944918
105positive regulation of fatty acid oxidation (GO:0046321)2.95889662
106plasma lipoprotein particle assembly (GO:0034377)2.95722500
107ethanol oxidation (GO:0006069)2.95575452
108actin-myosin filament sliding (GO:0033275)2.94213480
109muscle filament sliding (GO:0030049)2.94213480
110bile acid metabolic process (GO:0008206)2.91089224
111glutamate metabolic process (GO:0006536)2.90727176
112regulation of complement activation (GO:0030449)2.90177981
113protein-lipid complex assembly (GO:0065005)2.89088975
114histone arginine methylation (GO:0034969)2.88967124
115coenzyme catabolic process (GO:0009109)2.88848566
116maternal placenta development (GO:0001893)2.87732911
117tryptophan metabolic process (GO:0006568)2.87434447
118serine family amino acid catabolic process (GO:0009071)2.86082225
119regulation of cholesterol metabolic process (GO:0090181)2.85399442
120alpha-amino acid catabolic process (GO:1901606)2.85203565
121fatty acid transmembrane transport (GO:1902001)2.84371733
122regulation of triglyceride biosynthetic process (GO:0010866)2.84156072
123tricarboxylic acid cycle (GO:0006099)2.83000349
124regulation of cholesterol storage (GO:0010885)2.82803614
125positive regulation of fatty acid biosynthetic process (GO:0045723)2.82783952
126regulation of triglyceride metabolic process (GO:0090207)2.81461059
127glycosphingolipid catabolic process (GO:0046479)2.80824647
128glycolytic process (GO:0006096)2.80334264
129glycine metabolic process (GO:0006544)2.79800636
130phospholipid homeostasis (GO:0055091)2.79230997
131activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.78884603
132sarcoplasmic reticulum calcium ion transport (GO:0070296)2.78426709
133carnitine metabolic process (GO:0009437)2.76843754
134neutral lipid catabolic process (GO:0046461)2.76556457
135acylglycerol catabolic process (GO:0046464)2.76556457
136negative regulation of erythrocyte differentiation (GO:0045647)2.76474971
137regulation of lipid catabolic process (GO:0050994)2.75450414
138DNA unwinding involved in DNA replication (GO:0006268)2.75053112
139cellular amino acid catabolic process (GO:0009063)2.74909008
140positive regulation of nuclease activity (GO:0032075)2.72382130
141cellular protein complex localization (GO:0034629)2.68967305
142response to thyroid hormone (GO:0097066)2.66141031
143GDP-mannose metabolic process (GO:0019673)2.62483411
144glycolipid catabolic process (GO:0019377)2.61382376
145cellular hyperosmotic response (GO:0071474)2.60617648
146modulation by symbiont of host cellular process (GO:0044068)2.60551948
147skeletal muscle contraction (GO:0003009)2.58349078
148NIK/NF-kappaB signaling (GO:0038061)2.57212651
149negative regulation of necroptotic process (GO:0060546)2.56903651
150regulation of superoxide anion generation (GO:0032928)2.56559190
151pyrimidine nucleoside salvage (GO:0043097)2.56339233
152pyrimidine-containing compound salvage (GO:0008655)2.56339233
153epithelial cell differentiation involved in prostate gland development (GO:0060742)2.55550017
154protein complex localization (GO:0031503)2.55008406
155lipopolysaccharide biosynthetic process (GO:0009103)2.54933890
156pentose metabolic process (GO:0019321)2.54678810
157endoplasmic reticulum unfolded protein response (GO:0030968)2.54664459
158positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.52510306
159IMP metabolic process (GO:0046040)2.50242727
160peptidyl-arginine N-methylation (GO:0035246)2.49994382
161peptidyl-arginine methylation (GO:0018216)2.49994382
162apoptotic process involved in morphogenesis (GO:0060561)2.49306167
163ER-nucleus signaling pathway (GO:0006984)2.46502773
1643-UTR-mediated mRNA stabilization (GO:0070935)2.45957163
165galactose catabolic process (GO:0019388)2.42265608
166regulation of necrotic cell death (GO:0010939)2.42025529
167regulation of nuclease activity (GO:0032069)2.40996525
168activation of MAPKKK activity (GO:0000185)2.40723342
169regulation of early endosome to late endosome transport (GO:2000641)2.40705679
170modulation by virus of host morphology or physiology (GO:0019048)2.39887370
171regulation of mitochondrial membrane potential (GO:0051881)2.39212604
172positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.39194123
173nucleoside diphosphate biosynthetic process (GO:0009133)2.37951863
174cellular response to thyroid hormone stimulus (GO:0097067)2.37473035
175regulation of translational fidelity (GO:0006450)2.36929729
176regulation of glucose import in response to insulin stimulus (GO:2001273)2.36419811
177focal adhesion assembly (GO:0048041)2.35902914
178cell-substrate adherens junction assembly (GO:0007045)2.35902914
179deoxyribose phosphate biosynthetic process (GO:0046385)2.35814702
1802-deoxyribonucleotide biosynthetic process (GO:0009265)2.35814702
181cellular response to unfolded protein (GO:0034620)2.35055375
182IMP biosynthetic process (GO:0006188)2.34658032
183adherens junction assembly (GO:0034333)2.33516409
184glutamine family amino acid biosynthetic process (GO:0009084)2.32207241
185protein insertion into membrane (GO:0051205)2.30502407
186positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.29806266
187protoporphyrinogen IX metabolic process (GO:0046501)2.29620640

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.21317916
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.63381811
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.46172388
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.11228909
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.35016441
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.66676083
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.48807635
8LXR_22292898_ChIP-Seq_THP-1_Human2.48380418
9E2F7_22180533_ChIP-Seq_HELA_Human2.38992238
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.33451940
11ZNF263_19887448_ChIP-Seq_K562_Human2.33006629
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24927251
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.20894406
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17660467
15MYC_22102868_ChIP-Seq_BL_Human2.14918766
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.13451108
17* VDR_21846776_ChIP-Seq_THP-1_Human2.13030121
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.09887214
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.07685938
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02492541
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.91454488
22DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.91013205
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.90060709
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89569080
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.87227084
26CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.85948622
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.85921615
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.85512455
29KDM2B_26808549_Chip-Seq_DND41_Human1.83848635
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.83156945
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.82196546
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.81254019
33GATA1_22025678_ChIP-Seq_K562_Human1.71904697
34TCF7_22412390_ChIP-Seq_EML_Mouse1.70843121
35CLOCK_20551151_ChIP-Seq_293T_Human1.70823468
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.70217033
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66923712
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.66424886
39* RACK7_27058665_Chip-Seq_MCF-7_Human1.63088320
40MAF_26560356_Chip-Seq_TH1_Human1.60552531
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.59820941
42JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.59713913
43* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.58828630
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.58030490
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52947914
46GATA1_19941826_ChIP-Seq_K562_Human1.52130332
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52078265
48EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.48102508
49* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46631907
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.46075011
51MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45581366
52KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.45416995
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.43919713
54* GATA1_19941827_ChIP-Seq_MEL_Mouse1.43122831
55SCL_19346495_ChIP-Seq_HPC-7_Human1.41566965
56XRN2_22483619_ChIP-Seq_HELA_Human1.41343100
57CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.36461195
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36438526
59MYC_19079543_ChIP-ChIP_MESCs_Mouse1.34953638
60* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.34364347
61BCOR_27268052_Chip-Seq_Bcells_Human1.33558166
62HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.33387783
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32543928
64P68_20966046_ChIP-Seq_HELA_Human1.32376750
65ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.31416575
66* UTX_26944678_Chip-Seq_JUKART_Human1.31292293
67VDR_24763502_ChIP-Seq_THP-1_Human1.31099832
68TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.30908888
69NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.27810533
70CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.25794365
71BCL6_27268052_Chip-Seq_Bcells_Human1.25665685
72* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25292755
73TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25156219
74BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24960687
75DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24934533
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24858952
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24850277
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.24694959
79* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23637836
80KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23007148
81* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.22421599
82* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22092398
83SA1_27219007_Chip-Seq_ERYTHROID_Human1.22051544
84MAF_26560356_Chip-Seq_TH2_Human1.21654376
85* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21457982
86* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20394687
87CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20112101
88SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.18389555
89NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18001746
90MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17617466
91CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16547569
92* ESR2_21235772_ChIP-Seq_MCF-7_Human1.16189824
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14988805
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14660564
95CTCF_21964334_Chip-Seq_Bcells_Human1.14076550
96P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13759356
97* CREB1_26743006_Chip-Seq_LNCaP_Human1.13052047
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12850544
99* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12633276
100CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.12091421
101TET1_21451524_ChIP-Seq_MESCs_Mouse1.11594356
102GABP_19822575_ChIP-Seq_HepG2_Human1.11507362
103STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.11272458
104KDM2B_26808549_Chip-Seq_JURKAT_Human1.11199034
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09915193
106ATF3_27146783_Chip-Seq_COLON_Human1.09526130
107FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09384839
108NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08918937
109* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08390895
110GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08338260
111SMC4_20622854_ChIP-Seq_HELA_Human1.07857196
112PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07447514
113SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07363765
114EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07354289
115KDM2B_26808549_Chip-Seq_K562_Human1.07145341
116SA1_27219007_Chip-Seq_Bcells_Human1.06877775
117SPI1_23127762_ChIP-Seq_K562_Human1.06702859
118DCP1A_22483619_ChIP-Seq_HELA_Human1.06207669
119ELF1_17652178_ChIP-ChIP_JURKAT_Human1.06039101
120ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05535214
121TFEB_21752829_ChIP-Seq_HELA_Human1.05521935
122CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05176598
123GATA2_19941826_ChIP-Seq_K562_Human1.04616953
124ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04508944
125SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04370917
126POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03886144
127CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03670056
128ETS1_20019798_ChIP-Seq_JURKAT_Human1.03622986
129PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02501631
130PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02320409
131SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01978277
132TBX20_22080862_ChIP-Seq_HEART_Mouse1.01932629
133TBX20_22328084_ChIP-Seq_HEART_Mouse1.01932629
134ERG_21242973_ChIP-ChIP_JURKAT_Human1.01472684
135TBX5_21415370_ChIP-Seq_HL-1_Mouse1.01079149
136* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00458273
137RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99897002
138UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99558550
139RUNX1_22412390_ChIP-Seq_EML_Mouse0.97690130
140SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97583592
141RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97446734
142EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95045053
143FOXA2_19822575_ChIP-Seq_HepG2_Human0.95024265
144KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94464555
145STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94277589
146NCOR1_26117541_ChIP-Seq_K562_Human0.94177495
147EGR1_19374776_ChIP-ChIP_THP-1_Human0.93704633
148* CTCF_26484167_Chip-Seq_Bcells_Mouse0.92574098
149GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92441751
150SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92033419

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.91573586
2MP0005360_urolithiasis4.26173726
3MP0005365_abnormal_bile_salt3.82688386
4MP0009840_abnormal_foam_cell3.68496971
5MP0005085_abnormal_gallbladder_physiolo3.68049632
6MP0005083_abnormal_biliary_tract3.01398833
7MP0004233_abnormal_muscle_weight2.63299382
8MP0010329_abnormal_lipoprotein_level2.56684311
9MP0008875_abnormal_xenobiotic_pharmacok2.51449018
10MP0003191_abnormal_cellular_cholesterol2.37886606
11MP0003252_abnormal_bile_duct2.31638436
12MP0002837_dystrophic_cardiac_calcinosis2.23441098
13MP0008260_abnormal_autophagy2.20731157
14MP0001666_abnormal_nutrient_absorption2.13298671
15MP0003705_abnormal_hypodermis_morpholog2.09997765
16MP0004130_abnormal_muscle_cell2.07486173
17MP0004510_myositis2.04367954
18MP0009278_abnormal_bone_marrow2.04036212
19MP0003806_abnormal_nucleotide_metabolis1.92768989
20MP0004858_abnormal_nervous_system1.91119689
21MP0005332_abnormal_amino_acid1.89950371
22MP0000609_abnormal_liver_physiology1.88798338
23MP0008438_abnormal_cutaneous_collagen1.87942555
24MP0002138_abnormal_hepatobiliary_system1.84163449
25MP0002118_abnormal_lipid_homeostasis1.83189368
26MP0000685_abnormal_immune_system1.81913073
27MP0003195_calcinosis1.78714031
28MP0003300_gastrointestinal_ulcer1.77470554
29MP0000750_abnormal_muscle_regeneration1.75404874
30MP0005319_abnormal_enzyme/_coenzyme1.66356307
31MP0003656_abnormal_erythrocyte_physiolo1.65741004
32MP0001849_ear_inflammation1.63723311
33MP0003646_muscle_fatigue1.56974501
34MP0002332_abnormal_exercise_endurance1.56511455
35MP0000751_myopathy1.55795005
36MP0002909_abnormal_adrenal_gland1.53550143
37MP0003453_abnormal_keratinocyte_physiol1.48003521
38MP0000604_amyloidosis1.47231870
39MP0003303_peritoneal_inflammation1.46486323
40MP0005584_abnormal_enzyme/coenzyme_acti1.44249004
41MP0005058_abnormal_lysosome_morphology1.42590897
42MP0006036_abnormal_mitochondrial_physio1.41851281
43MP0003329_amyloid_beta_deposits1.40274668
44MP0005397_hematopoietic_system_phenotyp1.39269514
45MP0001545_abnormal_hematopoietic_system1.39269514
46MP0005165_increased_susceptibility_to1.34928669
47MP0005666_abnormal_adipose_tissue1.34807728
48MP0003436_decreased_susceptibility_to1.34618606
49MP0005330_cardiomyopathy1.33646071
50MP0009333_abnormal_splenocyte_physiolog1.33267139
51MP0004185_abnormal_adipocyte_glucose1.32370540
52MP0009643_abnormal_urine_homeostasis1.31865670
53MP0000733_abnormal_muscle_development1.30759602
54MP0000747_muscle_weakness1.29552600
55MP0005464_abnormal_platelet_physiology1.29293251
56MP0000858_altered_metastatic_potential1.28832900
57MP0001661_extended_life_span1.24126440
58MP0002078_abnormal_glucose_homeostasis1.23654854
59MP0003111_abnormal_nucleus_morphology1.22147032
60MP0000013_abnormal_adipose_tissue1.22056797
61MP0003186_abnormal_redox_activity1.20935636
62MP0005501_abnormal_skin_physiology1.20556366
63MP0004145_abnormal_muscle_electrophysio1.17794963
64MP0008469_abnormal_protein_level1.17401399
65MP0008961_abnormal_basal_metabolism1.17216894
66MP0003693_abnormal_embryo_hatching1.14813453
67MP0002796_impaired_skin_barrier1.13508683
68MP0002148_abnormal_hypersensitivity_rea1.13240616
69MP0005375_adipose_tissue_phenotype1.13225904
70MP0004087_abnormal_muscle_fiber1.13183400
71MP0000598_abnormal_liver_morphology1.13108803
72MP0000749_muscle_degeneration1.11094173
73MP0005076_abnormal_cell_differentiation1.11037150
74MP0002269_muscular_atrophy1.09984995
75MP0002971_abnormal_brown_adipose1.09378431
76MP0002060_abnormal_skin_morphology1.08733311
77MP0005670_abnormal_white_adipose1.07926047
78MP0004036_abnormal_muscle_relaxation1.07823239
79MP0009785_altered_susceptibility_to1.07382454
80MP0004947_skin_inflammation1.07310578
81MP0005257_abnormal_intraocular_pressure1.06690227
82MP0003279_aneurysm1.04648228
83MP0001730_embryonic_growth_arrest1.01408308
84MP0003075_altered_response_to1.00651346
85MP0001790_abnormal_immune_system0.99297144
86MP0005387_immune_system_phenotype0.99297144
87MP0005025_abnormal_response_to0.98511584
88MP0005334_abnormal_fat_pad0.97280233
89MP0005636_abnormal_mineral_homeostasis0.97219341
90MP0005535_abnormal_body_temperature0.96219873
91MP0000003_abnormal_adipose_tissue0.95714110
92MP0003221_abnormal_cardiomyocyte_apopto0.95080820
93MP0003868_abnormal_feces_composition0.93973032
94MP0009642_abnormal_blood_homeostasis0.93158394
95MP0001835_abnormal_antigen_presentation0.92961510
96MP0005166_decreased_susceptibility_to0.92303876
97MP0001853_heart_inflammation0.91939927
98MP0003566_abnormal_cell_adhesion0.90738283
99MP0003724_increased_susceptibility_to0.90680995
100MP0009763_increased_sensitivity_to0.89755269
101MP0004272_abnormal_basement_membrane0.86157783
102MP0000678_abnormal_parathyroid_gland0.85657182
103MP0003172_abnormal_lysosome_physiology0.85525697
104MP0005369_muscle_phenotype0.85073869
105MP0001765_abnormal_ion_homeostasis0.84588314
106MP0005023_abnormal_wound_healing0.83248205
107MP0003045_fibrosis0.83108073
108MP0000759_abnormal_skeletal_muscle0.83082752
109MP0009780_abnormal_chondrocyte_physiolo0.83050677
110MP0001727_abnormal_embryo_implantation0.82586104
111MP0002693_abnormal_pancreas_physiology0.82227950
112MP0002970_abnormal_white_adipose0.82043975
113MP0000681_abnormal_thyroid_gland0.81786780
114MP0010234_abnormal_vibrissa_follicle0.81723019
115MP0001845_abnormal_inflammatory_respons0.80729216
116MP0002877_abnormal_melanocyte_morpholog0.80345320
117MP0009672_abnormal_birth_weight0.80235239
118MP0002998_abnormal_bone_remodeling0.79847906
119MP0001533_abnormal_skeleton_physiology0.79665035
120MP0001944_abnormal_pancreas_morphology0.79513838
121MP0005451_abnormal_body_composition0.79409786
122MP0003091_abnormal_cell_migration0.78347154
123MP0010352_gastrointestinal_tract_polyps0.77036174
124MP0010630_abnormal_cardiac_muscle0.76597836
125MP0005621_abnormal_cell_physiology0.76300943
126MP0000313_abnormal_cell_death0.75699931
127MP0002106_abnormal_muscle_physiology0.74649075
128MP0005220_abnormal_exocrine_pancreas0.74354747
129MP0000358_abnormal_cell_content/0.74074406
130MP0004084_abnormal_cardiac_muscle0.72978454
131MP0002166_altered_tumor_susceptibility0.72511490
132MP0006082_CNS_inflammation0.72350221
133MP0000490_abnormal_crypts_of0.72205116
134MP0008775_abnormal_heart_ventricle0.72199963
135MP0005385_cardiovascular_system_phenoty0.72186150
136MP0001544_abnormal_cardiovascular_syste0.72186150
137MP0001348_abnormal_lacrimal_gland0.71898998
138MP0001800_abnormal_humoral_immune0.71737981
139MP0004808_abnormal_hematopoietic_stem0.71422960
140MP0009115_abnormal_fat_cell0.71162070
141MP0000343_altered_response_to0.70402763
142MP0002254_reproductive_system_inflammat0.70284923
143MP0003448_altered_tumor_morphology0.70163232
144MP0005448_abnormal_energy_balance0.69917016
145MP0010030_abnormal_orbit_morphology0.69784849
146MP0002080_prenatal_lethality0.69369371
147MP0001243_abnormal_dermal_layer0.68519523
148MP0008007_abnormal_cellular_replicative0.68113691
149MP0010155_abnormal_intestine_physiology0.67577619
150* MP0009931_abnormal_skin_appearance0.67540506
151MP0003828_pulmonary_edema0.67195497
152MP0003183_abnormal_peptide_metabolism0.67105836
153MP0002419_abnormal_innate_immunity0.66810609
154MP0001756_abnormal_urination0.66241640

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.49591119
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.43011163
3Muscle fiber inclusion bodies (HP:0100299)4.28782226
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.25248238
5Nemaline bodies (HP:0003798)4.24722922
6Xanthomatosis (HP:0000991)4.17363898
7Centrally nucleated skeletal muscle fibers (HP:0003687)4.07246313
8Ketosis (HP:0001946)3.83358793
9Myopathic facies (HP:0002058)3.80949552
10Type 1 muscle fiber predominance (HP:0003803)3.78686041
11Increased connective tissue (HP:0009025)3.65475707
12Distal lower limb muscle weakness (HP:0009053)3.58177944
13Hypoglycemic coma (HP:0001325)3.57564548
14Hyperlipoproteinemia (HP:0010980)3.57353957
15Intrahepatic cholestasis (HP:0001406)3.50043725
16Ketoacidosis (HP:0001993)3.45124765
17Myoglobinuria (HP:0002913)3.34560976
18Distal lower limb amyotrophy (HP:0008944)3.33217948
19Abnormality of monocarboxylic acid metabolism (HP:0010996)3.26376437
20Vertebral compression fractures (HP:0002953)3.25045731
21Abnormality of glycolipid metabolism (HP:0010969)3.18184769
22Abnormality of liposaccharide metabolism (HP:0010968)3.18184769
23Abnormality of glycosphingolipid metabolism (HP:0004343)3.18184769
24Exercise-induced myalgia (HP:0003738)3.10176987
25Hypobetalipoproteinemia (HP:0003563)3.05316557
26Abnormality of skeletal muscle fiber size (HP:0012084)3.00759333
27Abnormality of the common coagulation pathway (HP:0010990)2.96846110
28Hyperammonemia (HP:0001987)2.92828205
29Complement deficiency (HP:0004431)2.88325276
30Polycythemia (HP:0001901)2.87781397
31Asymmetric septal hypertrophy (HP:0001670)2.84085870
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.83927626
33Prolonged partial thromboplastin time (HP:0003645)2.79949327
34Abnormality of the nasal mucosa (HP:0000433)2.72726457
35Increased variability in muscle fiber diameter (HP:0003557)2.72489453
36Abnormality of the intrinsic pathway (HP:0010989)2.70829800
37EMG: myopathic abnormalities (HP:0003458)2.69091386
38Late onset (HP:0003584)2.67513320
39Hyperacusis (HP:0010780)2.64926392
40Abnormality of the Achilles tendon (HP:0005109)2.64289095
41Spinal rigidity (HP:0003306)2.63221750
42Cholecystitis (HP:0001082)2.62288606
43Abnormal gallbladder physiology (HP:0012438)2.62288606
44Abnormality of glutamine family amino acid metabolism (HP:0010902)2.56562605
45Ulnar deviation of the wrist (HP:0003049)2.53839354
46Cholelithiasis (HP:0001081)2.53499902
47Abnormality of fatty-acid metabolism (HP:0004359)2.53324517
48Hypolipoproteinemia (HP:0010981)2.52881507
49Neck muscle weakness (HP:0000467)2.50694836
50Nasal polyposis (HP:0100582)2.50601449
51Back pain (HP:0003418)2.50290700
52Premature rupture of membranes (HP:0001788)2.48505680
53Exercise-induced muscle cramps (HP:0003710)2.45665157
54Mildly elevated creatine phosphokinase (HP:0008180)2.44518182
55Hypoalphalipoproteinemia (HP:0003233)2.44165785
56Muscle fiber splitting (HP:0003555)2.43352918
57Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.41575604
58Abnormal gallbladder morphology (HP:0012437)2.41555199
59Abnormality of serine family amino acid metabolism (HP:0010894)2.40655540
60Abnormality of glycine metabolism (HP:0010895)2.40655540
61Hyperbilirubinemia (HP:0002904)2.38992674
62Achilles tendon contracture (HP:0001771)2.38370455
63Reticulocytosis (HP:0001923)2.37652017
64Abnormality of complement system (HP:0005339)2.35739305
65Sudden death (HP:0001699)2.35462429
66Joint hemorrhage (HP:0005261)2.35364690
67Bulbar palsy (HP:0001283)2.34024836
68Hyperinsulinemic hypoglycemia (HP:0000825)2.33441555
69Rhabdomyolysis (HP:0003201)2.32809609
70Increased cerebral lipofuscin (HP:0011813)2.32540354
71Hyperglycinemia (HP:0002154)2.32389213
72Hypercholesterolemia (HP:0003124)2.31924142
73Axonal loss (HP:0003447)2.29806640
74Insomnia (HP:0100785)2.27380969
75Round ear (HP:0100830)2.26903735
76Abnormality of dicarboxylic acid metabolism (HP:0010995)2.26250889
77Dicarboxylic aciduria (HP:0003215)2.26250889
78Lower limb amyotrophy (HP:0007210)2.26227487
79Hyperglycinuria (HP:0003108)2.25535359
80Diaphragmatic weakness (HP:0009113)2.23824660
81Hypertensive crisis (HP:0100735)2.17963909
82Trismus (HP:0000211)2.17721534
83Hyporeflexia of lower limbs (HP:0002600)2.17544255
84Fatigue (HP:0012378)2.17017122
85Generalized amyotrophy (HP:0003700)2.13479465
86Skin nodule (HP:0200036)2.13381617
87Protrusio acetabuli (HP:0003179)2.12903654
88Neonatal onset (HP:0003623)2.12557340
89Stridor (HP:0010307)2.12244177
90Gout (HP:0001997)2.11190361
91Increased serum ferritin (HP:0003281)2.10117280
92Delayed CNS myelination (HP:0002188)2.08930859
93Mitral stenosis (HP:0001718)2.08753688
94Nuclear cataract (HP:0100018)2.06694495
95Foot dorsiflexor weakness (HP:0009027)2.03566831
96Ragged-red muscle fibers (HP:0003200)2.01144026
97Interstitial pulmonary disease (HP:0006530)2.01100164
98Hypoglycemic seizures (HP:0002173)2.00142206
99Myocardial infarction (HP:0001658)1.99965905
100Right ventricular cardiomyopathy (HP:0011663)1.99892540
101Menorrhagia (HP:0000132)1.99603545
102Epidermoid cyst (HP:0200040)1.99384405
103Abnormality of iron homeostasis (HP:0011031)1.97746302
104Abnormality of glycolysis (HP:0004366)1.97344260
105Short nail (HP:0001799)1.95626553
106Chronic otitis media (HP:0000389)1.95506990
107Amyloidosis (HP:0011034)1.94013930
108Increased neuronal autofluorescent lipopigment (HP:0002074)1.93247383
109Rough bone trabeculation (HP:0100670)1.92317703
110Fat malabsorption (HP:0002630)1.92160820
111Generalized aminoaciduria (HP:0002909)1.90981336
112Abnormality of proline metabolism (HP:0010907)1.90780537
113Hydroxyprolinuria (HP:0003080)1.90780537
114Abnormality of purine metabolism (HP:0004352)1.90702620
115Limb-girdle muscle atrophy (HP:0003797)1.90683182
116Abnormality of sulfur amino acid metabolism (HP:0004339)1.89917249
117Metabolic acidosis (HP:0001942)1.89457751
118Abnormality of the umbilical cord (HP:0010881)1.89375494
119Muscle stiffness (HP:0003552)1.88415528
120Ventricular tachycardia (HP:0004756)1.87135985
121Abnormality of transition element cation homeostasis (HP:0011030)1.86938669
122Distal arthrogryposis (HP:0005684)1.86391785
123Systemic lupus erythematosus (HP:0002725)1.86086760
124Loss of speech (HP:0002371)1.85677647
125Reduced subcutaneous adipose tissue (HP:0003758)1.83532196
126Abnormality of mucopolysaccharide metabolism (HP:0011020)1.83521161
127Abnormality of polysaccharide metabolism (HP:0011012)1.83521161
128Abnormality of glycosaminoglycan metabolism (HP:0004371)1.83521161
129Progressive external ophthalmoplegia (HP:0000590)1.83392624
130Scapular winging (HP:0003691)1.82904963
131Urinary glycosaminoglycan excretion (HP:0003541)1.82807850
132Mucopolysacchariduria (HP:0008155)1.82807850
133Abnormality of the gallbladder (HP:0005264)1.82805309
134Abnormality of endocrine pancreas physiology (HP:0012093)1.82729094
135Abnormality of the pancreatic islet cells (HP:0006476)1.82729094
136Upper limb amyotrophy (HP:0009129)1.80783032
137Distal upper limb amyotrophy (HP:0007149)1.80783032
138Impaired platelet aggregation (HP:0003540)1.80756087
139Abnormal platelet function (HP:0011869)1.80756087
140Multiple enchondromatosis (HP:0005701)1.80277989
141Abnormality of the foot musculature (HP:0001436)1.79843933
142Dysostosis multiplex (HP:0000943)1.78532682
143Gingival bleeding (HP:0000225)1.77307440
144Abnormal cartilage morphology (HP:0002763)1.76739195
145Progressive muscle weakness (HP:0003323)1.76609562
146Atrioventricular block (HP:0001678)1.76515721
147Upper motor neuron abnormality (HP:0002127)1.75311285
148Increased serum pyruvate (HP:0003542)1.74453658
149Microvesicular hepatic steatosis (HP:0001414)1.74200994
150Calcaneovalgus deformity (HP:0001848)1.73374914
151Difficulty running (HP:0009046)1.73346225
152Vacuolated lymphocytes (HP:0001922)1.73080084
153Epistaxis (HP:0000421)1.72908886
154Spontaneous hematomas (HP:0007420)1.71055299
155Protuberant abdomen (HP:0001538)1.71044313
156Athetosis (HP:0002305)1.70678349
157Microcytic anemia (HP:0001935)1.70675959
158Stroke (HP:0001297)1.70663044
159Conjunctival hamartoma (HP:0100780)1.69970680
160Rimmed vacuoles (HP:0003805)1.69736134
161Difficulty climbing stairs (HP:0003551)1.69487602
162Abnormality of the distal phalanges of the toes (HP:0010182)1.69327376
163Shoulder girdle muscle weakness (HP:0003547)1.67973345
164Slender build (HP:0001533)1.65620105
165Abnormality of the tricuspid valve (HP:0001702)1.65277048
166Fasciculations (HP:0002380)1.65018708
167Thoracic kyphosis (HP:0002942)1.63167733
168Prolonged neonatal jaundice (HP:0006579)1.63063803
169Polygenic inheritance (HP:0010982)1.62890446
170Hepatosplenomegaly (HP:0001433)1.61984592
171Abnormality of the thoracic spine (HP:0100711)1.61716376
172Natal tooth (HP:0000695)1.60501800
173Elbow flexion contracture (HP:0002987)1.59691413

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.22994408
2ERN14.14928542
3PKN24.05670392
4BCKDK3.31213149
5SMG13.22920406
6TESK12.66808761
7PRPF4B2.60698943
8FGFR42.50830713
9MAP4K12.13384850
10MAP3K102.12708239
11TTN2.11889317
12SIK12.11494612
13TYK22.08636039
14EEF2K2.07155867
15TAOK22.00729516
16FLT31.89524911
17VRK21.89508894
18EPHB11.85845396
19PTK61.77699781
20TBK11.67718439
21EPHA21.62912390
22LIMK11.57370862
23MAP3K31.47865748
24LRRK21.46765300
25JAK11.43075646
26KSR21.35993317
27JAK31.33205069
28TAOK31.32245351
29PAK41.28883322
30MAP3K71.28494498
31MAP3K131.21428821
32BUB11.18645031
33MAPK111.17758108
34RIPK11.17131829
35BLK1.16638924
36PHKG11.14814415
37PHKG21.14814415
38MAP3K11.14766862
39MAP3K111.14305368
40ZAP701.12842352
41RET1.12106996
42KIT1.11143038
43PDGFRA1.06959744
44LMTK21.06904537
45SCYL21.06050659
46JAK21.05007777
47PRKD31.01403656
48TAOK11.00784930
49CAMKK10.99317007
50INSRR0.97621695
51NTRK10.94966777
52ICK0.93758125
53PBK0.93140085
54MOS0.92262358
55HIPK20.91667301
56GRK60.91017872
57DAPK10.87588060
58IKBKE0.87200643
59BTK0.81122013
60MAP2K30.81004150
61DDR20.78504696
62PIM20.78039353
63RPS6KB20.77357001
64KDR0.76554890
65BRAF0.75398717
66EPHA30.75379849
67CAMK2G0.74621193
68ILK0.74203219
69BMX0.74141170
70TGFBR20.73811070
71CSK0.72704359
72PDK30.72245908
73PDK40.72245908
74MAP3K20.71440969
75AURKA0.71297711
76DAPK30.71015461
77DYRK1B0.70447351
78ARAF0.69833737
79PDPK10.69658391
80CDC42BPA0.69232172
81NEK10.69065548
82CCNB10.68687184
83FGFR30.67252166
84PDK10.66320525
85SYK0.66118164
86AKT20.65221893
87PRKD10.64608815
88NME20.63746834
89CSF1R0.63102936
90ALK0.62476862
91PTK2B0.61976061
92MST1R0.61858579
93EIF2AK10.61768083
94PRKCH0.61443971
95DAPK20.61078272
96MAP2K20.60925205
97CDK70.60214387
98FES0.59899417
99MAPK150.56948662
100CDK90.55345748
101CDK120.55219171
102SIK20.54912929
103MAP3K90.54423722
104TIE10.51561936
105HCK0.51093212
106MAPK120.51008564
107IRAK20.50885309
108PAK10.49361946
109LATS20.49164135
110PTK20.48459452
111CDK40.47725154
112CAMKK20.46282160
113RPS6KL10.46193658
114RPS6KC10.46193658
115RAF10.45673604
116OBSCN0.45501196
117RPS6KA20.45344601
118DMPK0.43786702
119STK160.43046535
120PRKD20.42795134
121TLK10.42773370
122MAPK40.42318419
123PIK3CG0.42014481
124MATK0.41695932
125NEK90.41640778
126PINK10.41493495
127TESK20.40429889
128MAP3K80.40335394
129PAK60.39816703
130PAK20.39204725
131MAPKAPK20.38975151
132CAMK1D0.38441337
133MAP3K140.37877377
134RPS6KA40.37681806
135STK100.36893614
136MTOR0.36391878
137MAPKAPK30.35605629
138CAMK1G0.35376931
139ABL20.34431485
140ERBB40.34015784
141CDK80.33678126
142CDK11A0.33598057
143IRAK30.32137588
144PRKG20.31784683
145PRKAA20.31769817
146CDK150.30944053
147MAP3K50.29849065
148CDK140.29783561

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.90442786
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.42919297
3Nitrogen metabolism_Homo sapiens_hsa009103.37477829
4Other glycan degradation_Homo sapiens_hsa005113.08115898
5Fatty acid degradation_Homo sapiens_hsa000712.79126254
6Arginine biosynthesis_Homo sapiens_hsa002202.75429415
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.42608556
8Tryptophan metabolism_Homo sapiens_hsa003802.32548800
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.26857349
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.26142576
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.24086541
12DNA replication_Homo sapiens_hsa030302.12144284
13Base excision repair_Homo sapiens_hsa034102.00239482
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.99169097
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.96624225
16Propanoate metabolism_Homo sapiens_hsa006401.95894869
17Fatty acid metabolism_Homo sapiens_hsa012121.93014714
18PPAR signaling pathway_Homo sapiens_hsa033201.84848015
19Butanoate metabolism_Homo sapiens_hsa006501.83028091
20Complement and coagulation cascades_Homo sapiens_hsa046101.77953757
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.69267111
22Carbon metabolism_Homo sapiens_hsa012001.59693439
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.58547620
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.56424815
25Caffeine metabolism_Homo sapiens_hsa002321.50402525
26Peroxisome_Homo sapiens_hsa041461.48345457
27Starch and sucrose metabolism_Homo sapiens_hsa005001.46990814
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.45743745
29Bile secretion_Homo sapiens_hsa049761.42914745
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.40842222
31Staphylococcus aureus infection_Homo sapiens_hsa051501.37876400
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.35850352
33Pyruvate metabolism_Homo sapiens_hsa006201.34642792
34ABC transporters_Homo sapiens_hsa020101.34046014
35Biosynthesis of amino acids_Homo sapiens_hsa012301.31768681
36Selenocompound metabolism_Homo sapiens_hsa004501.30954781
37Insulin resistance_Homo sapiens_hsa049311.27666286
38Vibrio cholerae infection_Homo sapiens_hsa051101.27127300
39Proteasome_Homo sapiens_hsa030501.24193466
40beta-Alanine metabolism_Homo sapiens_hsa004101.23688983
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21299996
42Fat digestion and absorption_Homo sapiens_hsa049751.20252572
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.17693820
44Adipocytokine signaling pathway_Homo sapiens_hsa049201.16149013
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12082828
46Sulfur relay system_Homo sapiens_hsa041221.11462106
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10625574
48Vitamin B6 metabolism_Homo sapiens_hsa007501.10075287
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.09218421
50Phenylalanine metabolism_Homo sapiens_hsa003601.08458298
51Pyrimidine metabolism_Homo sapiens_hsa002401.06144941
52Glutathione metabolism_Homo sapiens_hsa004801.06078906
53Fructose and mannose metabolism_Homo sapiens_hsa000511.03049660
54Histidine metabolism_Homo sapiens_hsa003401.02237895
55Galactose metabolism_Homo sapiens_hsa000521.02152219
56Pentose phosphate pathway_Homo sapiens_hsa000301.01900284
57Folate biosynthesis_Homo sapiens_hsa007901.01430511
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.00595897
59Salmonella infection_Homo sapiens_hsa051320.94311662
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92518430
61Shigellosis_Homo sapiens_hsa051310.92434108
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88276237
63Insulin signaling pathway_Homo sapiens_hsa049100.87309114
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.86238390
65Sulfur metabolism_Homo sapiens_hsa009200.83508258
66Glycerolipid metabolism_Homo sapiens_hsa005610.80246700
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.77507919
68Arginine and proline metabolism_Homo sapiens_hsa003300.76610863
69Apoptosis_Homo sapiens_hsa042100.76223726
70Lysine degradation_Homo sapiens_hsa003100.74875549
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74569615
72Type II diabetes mellitus_Homo sapiens_hsa049300.73628618
73Pertussis_Homo sapiens_hsa051330.73194425
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72372695
75N-Glycan biosynthesis_Homo sapiens_hsa005100.72047827
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71989831
77Chemical carcinogenesis_Homo sapiens_hsa052040.68629127
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68189068
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67620104
80AMPK signaling pathway_Homo sapiens_hsa041520.67600199
81Acute myeloid leukemia_Homo sapiens_hsa052210.67467165
82Fatty acid elongation_Homo sapiens_hsa000620.67171555
83Glucagon signaling pathway_Homo sapiens_hsa049220.66744200
84B cell receptor signaling pathway_Homo sapiens_hsa046620.66512190
85Pancreatic cancer_Homo sapiens_hsa052120.63875562
86Prion diseases_Homo sapiens_hsa050200.61764686
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.57408484
88Tyrosine metabolism_Homo sapiens_hsa003500.56505666
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55684502
90VEGF signaling pathway_Homo sapiens_hsa043700.54698898
91Hepatitis C_Homo sapiens_hsa051600.54456859
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54381193
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53687228
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53509031
95Legionellosis_Homo sapiens_hsa051340.52093928
96Spliceosome_Homo sapiens_hsa030400.51157295
97Epstein-Barr virus infection_Homo sapiens_hsa051690.50651251
98Fatty acid biosynthesis_Homo sapiens_hsa000610.50491384
99Viral carcinogenesis_Homo sapiens_hsa052030.47740658
100Thyroid cancer_Homo sapiens_hsa052160.47397743
101Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46373951
102TNF signaling pathway_Homo sapiens_hsa046680.46120040
103HTLV-I infection_Homo sapiens_hsa051660.45613919
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.45366017
105One carbon pool by folate_Homo sapiens_hsa006700.45288167
106Notch signaling pathway_Homo sapiens_hsa043300.45170542
107Endocytosis_Homo sapiens_hsa041440.43921634
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.43530153
109Herpes simplex infection_Homo sapiens_hsa051680.42818419
110Chronic myeloid leukemia_Homo sapiens_hsa052200.41571750
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41436366
112Influenza A_Homo sapiens_hsa051640.40813699
113Prolactin signaling pathway_Homo sapiens_hsa049170.39437800
114NF-kappa B signaling pathway_Homo sapiens_hsa040640.39379492
115Amoebiasis_Homo sapiens_hsa051460.39349951
116Hepatitis B_Homo sapiens_hsa051610.39228408
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39055814
118Osteoclast differentiation_Homo sapiens_hsa043800.38206520
119Nucleotide excision repair_Homo sapiens_hsa034200.38101029
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37975117
121Lysosome_Homo sapiens_hsa041420.37310947
122Bladder cancer_Homo sapiens_hsa052190.36842532
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35030279
124Viral myocarditis_Homo sapiens_hsa054160.34852294
125Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33989616
126Mismatch repair_Homo sapiens_hsa034300.33296895
127Retinol metabolism_Homo sapiens_hsa008300.32949046
128Platelet activation_Homo sapiens_hsa046110.32632775
129Sphingolipid metabolism_Homo sapiens_hsa006000.31121708
130Leishmaniasis_Homo sapiens_hsa051400.30268607
131Focal adhesion_Homo sapiens_hsa045100.30152391
132Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29204403
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28454106
134Non-small cell lung cancer_Homo sapiens_hsa052230.28225313
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27485324
136Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27460976
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26971658
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26369900
139Toxoplasmosis_Homo sapiens_hsa051450.25328072
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24083335
141Glycosaminoglycan degradation_Homo sapiens_hsa005310.24077015
142mTOR signaling pathway_Homo sapiens_hsa041500.23285792
143Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21408756
144Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20522858
145Steroid hormone biosynthesis_Homo sapiens_hsa001400.18575585
146Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.18498639
147HIF-1 signaling pathway_Homo sapiens_hsa040660.18045831
148Dilated cardiomyopathy_Homo sapiens_hsa054140.17388406
149Antigen processing and presentation_Homo sapiens_hsa046120.16893419
150Glioma_Homo sapiens_hsa052140.16366818

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