KHDRBS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell cycle regulation, RNA 3'-end formation, tumorigenesis, and regulation of human immunodeficiency virus gene expression. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.05555908
2protein localization to kinetochore (GO:0034501)4.73363395
3viral transcription (GO:0019083)4.68458184
4ribosomal small subunit biogenesis (GO:0042274)4.58177277
5translational termination (GO:0006415)4.52838400
6negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.32976843
7establishment of integrated proviral latency (GO:0075713)4.31437673
8maturation of SSU-rRNA (GO:0030490)4.05968585
9negative regulation of RNA splicing (GO:0033119)4.04157187
10pre-miRNA processing (GO:0031054)4.04089216
11nuclear pore complex assembly (GO:0051292)3.97014732
12nuclear pore organization (GO:0006999)3.95765883
13protein localization to chromosome, centromeric region (GO:0071459)3.92197337
14ribosomal small subunit assembly (GO:0000028)3.85883339
15mitotic sister chromatid cohesion (GO:0007064)3.84601452
16glucocorticoid receptor signaling pathway (GO:0042921)3.79966659
17translational elongation (GO:0006414)3.77778948
18formation of translation preinitiation complex (GO:0001731)3.76905345
19negative regulation of mRNA processing (GO:0050686)3.73689359
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.71727921
21cotranslational protein targeting to membrane (GO:0006613)3.67734949
22protein targeting to ER (GO:0045047)3.64164485
23translational initiation (GO:0006413)3.62041711
24cellular protein complex disassembly (GO:0043624)3.60545812
25protein complex disassembly (GO:0043241)3.59720934
26paraxial mesoderm development (GO:0048339)3.58457634
27planar cell polarity pathway involved in neural tube closure (GO:0090179)3.54825531
28viral life cycle (GO:0019058)3.54604323
29regulation of sister chromatid cohesion (GO:0007063)3.53489285
30establishment of protein localization to endoplasmic reticulum (GO:0072599)3.53199352
31regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.51910939
32RNA stabilization (GO:0043489)3.48506559
33mRNA stabilization (GO:0048255)3.48506559
34sister chromatid segregation (GO:0000819)3.48051964
35regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.47751928
36negative regulation of mRNA metabolic process (GO:1903312)3.41489958
37macromolecular complex disassembly (GO:0032984)3.37525631
38telomere maintenance via semi-conservative replication (GO:0032201)3.36125114
39alternative mRNA splicing, via spliceosome (GO:0000380)3.33649504
40protein localization to endoplasmic reticulum (GO:0070972)3.29808525
41DNA duplex unwinding (GO:0032508)3.27914674
42chromosome condensation (GO:0030261)3.25633113
43ribosomal large subunit biogenesis (GO:0042273)3.25475796
44regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.25115402
45DNA geometric change (GO:0032392)3.24206529
46negative regulation of histone methylation (GO:0031061)3.22213719
47mitotic nuclear envelope disassembly (GO:0007077)3.20103305
48dosage compensation (GO:0007549)3.17161326
49protein localization to chromosome (GO:0034502)3.15280885
50corticosteroid receptor signaling pathway (GO:0031958)3.14464825
51establishment of viral latency (GO:0019043)3.13901418
52convergent extension (GO:0060026)3.12985276
533-UTR-mediated mRNA stabilization (GO:0070935)3.12469312
54pore complex assembly (GO:0046931)3.08082904
55kinetochore organization (GO:0051383)3.07780976
56nuclear envelope disassembly (GO:0051081)3.06507161
57membrane disassembly (GO:0030397)3.06507161
58mitotic sister chromatid segregation (GO:0000070)3.04386923
59protein complex localization (GO:0031503)3.03828188
60heterochromatin organization (GO:0070828)3.03771928
61mitotic chromosome condensation (GO:0007076)3.01903464
62DNA topological change (GO:0006265)3.00258867
63DNA replication-independent nucleosome organization (GO:0034724)2.99356998
64DNA replication-independent nucleosome assembly (GO:0006336)2.99356998
65protein-DNA complex disassembly (GO:0032986)2.98445067
66nucleosome disassembly (GO:0006337)2.98445067
67positive regulation of chromosome segregation (GO:0051984)2.97658332
68regulation of mRNA stability (GO:0043488)2.97152003
69translesion synthesis (GO:0019985)2.94629168
70chromatin remodeling at centromere (GO:0031055)2.89868566
71mRNA splice site selection (GO:0006376)2.89667624
72peptidyl-arginine omega-N-methylation (GO:0035247)2.89411321
73peptidyl-lysine dimethylation (GO:0018027)2.87080443
74DNA replication checkpoint (GO:0000076)2.84867118
75regulation of histone H3-K9 methylation (GO:0051570)2.84845573
76mitotic recombination (GO:0006312)2.83940076
77nuclear-transcribed mRNA catabolic process (GO:0000956)2.83912837
78hippo signaling (GO:0035329)2.83517176
79CENP-A containing nucleosome assembly (GO:0034080)2.82693268
80ribonucleoprotein complex biogenesis (GO:0022613)2.81606587
81histone H2A monoubiquitination (GO:0035518)2.81488588
82telomere maintenance via recombination (GO:0000722)2.79103455
83histone H2B ubiquitination (GO:0033523)2.77759831
84regulation of RNA stability (GO:0043487)2.77270744
85cellular protein complex localization (GO:0034629)2.77209100
86mRNA catabolic process (GO:0006402)2.75533026
87chromatin assembly (GO:0031497)2.72501708
88peptidyl-arginine methylation (GO:0018216)2.72349202
89peptidyl-arginine N-methylation (GO:0035246)2.72349202
90IMP biosynthetic process (GO:0006188)2.70576201
91DNA packaging (GO:0006323)2.70569625
92mRNA splicing, via spliceosome (GO:0000398)2.68577299
93RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.68577299
94RNA catabolic process (GO:0006401)2.67969466
95DNA ligation (GO:0006266)2.67846796
96positive regulation of RNA splicing (GO:0033120)2.67237590
97mitotic metaphase plate congression (GO:0007080)2.64377636
98RNA splicing, via transesterification reactions (GO:0000375)2.63682864
99regulation of translational fidelity (GO:0006450)2.59520685
100positive regulation of mitotic sister chromatid separation (GO:1901970)2.57804860
101positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.57804860
102positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.57804860
103nuclear envelope organization (GO:0006998)2.57402810
104regulation of protein heterodimerization activity (GO:0043497)2.55616452
105spliceosomal tri-snRNP complex assembly (GO:0000244)2.54829981
106* regulation of RNA export from nucleus (GO:0046831)2.53422164
107DNA conformation change (GO:0071103)2.52481603
108DNA replication initiation (GO:0006270)2.52211555
109ATP-dependent chromatin remodeling (GO:0043044)2.52046534
110regulation of chromosome segregation (GO:0051983)2.52045113
111termination of RNA polymerase II transcription (GO:0006369)2.49351405
112folic acid-containing compound biosynthetic process (GO:0009396)2.49095639
113DNA strand elongation involved in DNA replication (GO:0006271)2.48016396
114regulation of DNA damage checkpoint (GO:2000001)2.47241832
115regulation of DNA endoreduplication (GO:0032875)2.45591367
116regulation of histone H3-K4 methylation (GO:0051569)2.45129683
117metaphase plate congression (GO:0051310)2.43206053
118positive regulation of gene expression, epigenetic (GO:0045815)2.41862984
119chromatin assembly or disassembly (GO:0006333)2.41232796
120negative regulation of gene expression, epigenetic (GO:0045814)2.41087715
121mRNA transport (GO:0051028)2.39793139
122NLS-bearing protein import into nucleus (GO:0006607)2.39380564
123DNA replication-dependent nucleosome organization (GO:0034723)2.36984056
124DNA replication-dependent nucleosome assembly (GO:0006335)2.36984056
125nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.34332881
126polarized epithelial cell differentiation (GO:0030859)2.34185434
127germ cell migration (GO:0008354)2.34183974
128DNA strand elongation (GO:0022616)2.33934057
129cytoplasmic mRNA processing body assembly (GO:0033962)2.32938412
130positive regulation of histone deacetylation (GO:0031065)2.32341554
131regulation of stem cell maintenance (GO:2000036)2.31879433
132positive regulation of cell cycle G2/M phase transition (GO:1902751)2.31796024
133positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.31796024
134regulation of spindle organization (GO:0090224)2.31434656
135histone H3-K36 demethylation (GO:0070544)2.31028655
136mitotic spindle checkpoint (GO:0071174)2.30824374
137positive regulation of histone H3-K4 methylation (GO:0051571)2.30494091
138regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.27530503
139spindle checkpoint (GO:0031577)2.27100844
140spindle assembly checkpoint (GO:0071173)2.27020122
141postreplication repair (GO:0006301)2.25368541
142negative regulation of DNA repair (GO:0045738)2.24713041
143V(D)J recombination (GO:0033151)2.24564012
144mitotic spindle assembly checkpoint (GO:0007094)2.24534035

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.60673420
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.66572299
3EGR1_19374776_ChIP-ChIP_THP-1_Human5.00972454
4MYC_22102868_ChIP-Seq_BL_Human3.77582082
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.66948202
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.17144773
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.04675241
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.91889235
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.64464977
10* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.54168950
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.30234330
12VDR_21846776_ChIP-Seq_THP-1_Human2.29242574
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.26654576
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.26013161
15CIITA_25753668_ChIP-Seq_RAJI_Human2.16304830
16TCF7_22412390_ChIP-Seq_EML_Mouse2.11206903
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.04264949
18AR_21909140_ChIP-Seq_LNCAP_Human2.00933221
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.00429038
20STAT6_21828071_ChIP-Seq_BEAS2B_Human1.96574214
21CREB1_15753290_ChIP-ChIP_HEK293T_Human1.93844775
22KDM2B_26808549_Chip-Seq_DND41_Human1.93573653
23* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.92638768
24* XRN2_22483619_ChIP-Seq_HELA_Human1.86207645
25THAP11_20581084_ChIP-Seq_MESCs_Mouse1.85170973
26* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.79777208
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70391389
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.68566556
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.68566556
30KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.68566556
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.66584562
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64590971
33* UTX_26944678_Chip-Seq_JUKART_Human1.62612560
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.62588679
35CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.61931771
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61337650
37* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.57001567
38* MAF_26560356_Chip-Seq_TH1_Human1.56926405
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.55173950
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.54367660
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54328898
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51614146
43ZFP281_27345836_Chip-Seq_ESCs_Mouse1.51123105
44* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.47246639
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.46709656
46* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.46688526
47* KDM2B_26808549_Chip-Seq_JURKAT_Human1.44278822
48* ELK3_25401928_ChIP-Seq_HUVEC_Human1.43635109
49* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.42986789
50* MYB_26560356_Chip-Seq_TH2_Human1.39188509
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38380505
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.36862999
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35690633
54* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34176304
55* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.34127852
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33414324
57DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.33111927
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32969207
59DCP1A_22483619_ChIP-Seq_HELA_Human1.32560199
60KDM5A_27292631_Chip-Seq_BREAST_Human1.32229097
61ETS1_20019798_ChIP-Seq_JURKAT_Human1.29524030
62* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29488772
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28943276
64TTF2_22483619_ChIP-Seq_HELA_Human1.25799512
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25737631
66VDR_24763502_ChIP-Seq_THP-1_Human1.25147156
67* CHD1_26751641_Chip-Seq_LNCaP_Human1.24680792
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23754311
69KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.23624828
70EST1_17652178_ChIP-ChIP_JURKAT_Human1.23585786
71* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.23580722
72* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23427644
73TCF3_18692474_ChIP-Seq_MEFs_Mouse1.22681979
74* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22272268
75* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22145092
76NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21203902
77* MYB_26560356_Chip-Seq_TH1_Human1.20251623
78SOX2_16153702_ChIP-ChIP_HESCs_Human1.19617676
79SCL_19346495_ChIP-Seq_HPC-7_Human1.18189483
80ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16522251
81FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15417771
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15262134
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14924390
84* NANOG_21062744_ChIP-ChIP_HESCs_Human1.14487532
85* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.14200135
86* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14109879
87ZNF263_19887448_ChIP-Seq_K562_Human1.13910864
88* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13769006
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12856004
90HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.12624559
91EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11383927
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10947918
93ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09612545
94* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09545911
95* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.09301530
96OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06845658
97MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06433792
98CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05635290
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05406193
100FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.05108494
101NCOR1_26117541_ChIP-Seq_K562_Human1.04793477
102MAF_26560356_Chip-Seq_TH2_Human1.04285160
103SOX2_18692474_ChIP-Seq_MEFs_Mouse1.03295842
104PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03077711
105SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02047616
106TP63_17297297_ChIP-ChIP_HaCaT_Human1.00899655
107WT1_19549856_ChIP-ChIP_CCG9911_Human1.00861705
108RUNX1_22412390_ChIP-Seq_EML_Mouse1.00797412
109KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00725929
110JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.00308969
111SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00099504
112EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98360999
113* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.98256684
114* NANOG_16153702_ChIP-ChIP_HESCs_Human0.97861534
115SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97130062
116* SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.96637782
117GATA1_26923725_Chip-Seq_HPCs_Mouse0.95320060
118KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94477400
119ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94386757
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92811657
121FOXP3_21729870_ChIP-Seq_TREG_Human0.92303653
122POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91901344
123STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91402868
124RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90113992
125* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90065480
126POU5F1_16518401_ChIP-PET_MESCs_Mouse0.89815339
127SOX17_20123909_ChIP-Seq_XEN_Mouse0.89575347
128STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.89401359
129CLOCK_20551151_ChIP-Seq_293T_Human0.88886034
130* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.88847963
131TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.87460934
132TP53_22127205_ChIP-Seq_IMR90_Human0.86284733
133VDR_23849224_ChIP-Seq_CD4+_Human0.84463912
134* GABP_19822575_ChIP-Seq_HepG2_Human0.84281199
135SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.83348670
136* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83262158
137TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83237231
138FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.83184727

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000537_abnormal_urethra_morphology2.89918990
2MP0009379_abnormal_foot_pigmentation2.89864019
3MP0003111_abnormal_nucleus_morphology2.86280285
4MP0005076_abnormal_cell_differentiation2.77854763
5MP0010352_gastrointestinal_tract_polyps2.73082738
6MP0003123_paternal_imprinting2.68781873
7MP0010094_abnormal_chromosome_stability2.68722489
8MP0000566_synostosis2.57884619
9MP0003077_abnormal_cell_cycle2.53144013
10MP0008057_abnormal_DNA_replication2.45312589
11MP0004957_abnormal_blastocyst_morpholog2.43969100
12MP0003121_genomic_imprinting2.27164149
13MP0006292_abnormal_olfactory_placode2.24405208
14MP0003693_abnormal_embryo_hatching2.20275609
15MP0002396_abnormal_hematopoietic_system2.17786159
16MP0008007_abnormal_cellular_replicative2.02648825
17MP0004808_abnormal_hematopoietic_stem1.96898212
18MP0009278_abnormal_bone_marrow1.94680973
19MP0000350_abnormal_cell_proliferation1.90503721
20MP0003303_peritoneal_inflammation1.88763976
21MP0003122_maternal_imprinting1.85818318
22MP0000569_abnormal_digit_pigmentation1.84773928
23MP0010030_abnormal_orbit_morphology1.84674777
24MP0001730_embryonic_growth_arrest1.81195836
25MP0006054_spinal_hemorrhage1.80755359
26MP0002084_abnormal_developmental_patter1.73607254
27MP0004197_abnormal_fetal_growth/weight/1.70280627
28MP0003705_abnormal_hypodermis_morpholog1.67589403
29MP0009053_abnormal_anal_canal1.66532985
30MP0002009_preneoplasia1.63023541
31MP0002085_abnormal_embryonic_tissue1.61694390
32MP0000428_abnormal_craniofacial_morphol1.59100584
33MP0000733_abnormal_muscle_development1.57997493
34MP0010307_abnormal_tumor_latency1.56495924
35MP0003300_gastrointestinal_ulcer1.56337046
36MP0001286_abnormal_eye_development1.53672902
37MP0000490_abnormal_crypts_of1.53241492
38MP0001697_abnormal_embryo_size1.53082488
39MP0010234_abnormal_vibrissa_follicle1.52353815
40MP0001672_abnormal_embryogenesis/_devel1.52245096
41MP0005380_embryogenesis_phenotype1.52245096
42MP0008932_abnormal_embryonic_tissue1.52061719
43MP0003941_abnormal_skin_development1.50799065
44MP0000703_abnormal_thymus_morphology1.49293371
45MP0001346_abnormal_lacrimal_gland1.48681258
46MP0003567_abnormal_fetal_cardiomyocyte1.46468135
47MP0003984_embryonic_growth_retardation1.44276774
48MP0002088_abnormal_embryonic_growth/wei1.43617848
49MP0001849_ear_inflammation1.41802661
50MP0002086_abnormal_extraembryonic_tissu1.38693317
51MP0003763_abnormal_thymus_physiology1.35771624
52MP0002080_prenatal_lethality1.35723218
53MP0003283_abnormal_digestive_organ1.33062445
54MP0003787_abnormal_imprinting1.30601536
55MP0001188_hyperpigmentation1.29484662
56MP0004185_abnormal_adipocyte_glucose1.29444453
57MP0002249_abnormal_larynx_morphology1.29031732
58MP0003385_abnormal_body_wall1.27457984
59MP0005187_abnormal_penis_morphology1.20820283
60MP0000778_abnormal_nervous_system1.18250987
61MP0003937_abnormal_limbs/digits/tail_de1.17498583
62MP0002398_abnormal_bone_marrow1.16442068
63MP0001293_anophthalmia1.16287689
64MP0005623_abnormal_meninges_morphology1.16080123
65MP0003890_abnormal_embryonic-extraembry1.14605937
66MP0003935_abnormal_craniofacial_develop1.14052647
67MP0003119_abnormal_digestive_system1.13689804
68MP0008058_abnormal_DNA_repair1.12147075
69MP0003861_abnormal_nervous_system1.10867827
70MP0009703_decreased_birth_body1.09058745
71MP0002092_abnormal_eye_morphology1.08580761
72MP0003115_abnormal_respiratory_system1.08248849
73MP0003942_abnormal_urinary_system1.05840179
74MP0009672_abnormal_birth_weight1.05488965
75MP0001915_intracranial_hemorrhage1.05389741
76MP0002877_abnormal_melanocyte_morpholog1.04514166
77MP0008961_abnormal_basal_metabolism1.04172458
78MP0000313_abnormal_cell_death1.03745635
79MP0002019_abnormal_tumor_incidence1.03168479
80MP0002932_abnormal_joint_morphology1.01687598
81MP0002925_abnormal_cardiovascular_devel1.01093591
82MP0005397_hematopoietic_system_phenotyp1.00959662
83MP0001545_abnormal_hematopoietic_system1.00959662
84MP0002282_abnormal_trachea_morphology0.99964923
85MP0001299_abnormal_eye_distance/0.99207053
86MP0000762_abnormal_tongue_morphology0.96922927
87MP0003755_abnormal_palate_morphology0.96205487
88MP0000579_abnormal_nail_morphology0.95084107
89MP0002697_abnormal_eye_size0.95014107
90MP0003566_abnormal_cell_adhesion0.94288275
91MP0002116_abnormal_craniofacial_bone0.93029942
92MP0002722_abnormal_immune_system0.92776784
93MP0000432_abnormal_head_morphology0.91793069
94MP0002938_white_spotting0.91561081
95MP0002111_abnormal_tail_morphology0.90282174
96MP0002796_impaired_skin_barrier0.88726926
97MP0002089_abnormal_postnatal_growth/wei0.87892169
98MP0003938_abnormal_ear_development0.87528697
99MP0008877_abnormal_DNA_methylation0.86981267
100MP0008770_decreased_survivor_rate0.86442852
101MP0009697_abnormal_copulation0.86053822
102MP0002653_abnormal_ependyma_morphology0.85697937
103MP0003136_yellow_coat_color0.85264443
104MP0003091_abnormal_cell_migration0.85255588
105MP0009250_abnormal_appendicular_skeleto0.85118589
106MP0000049_abnormal_middle_ear0.84843550
107MP0009333_abnormal_splenocyte_physiolog0.84402484
108MP0000685_abnormal_immune_system0.84011030
109MP0001340_abnormal_eyelid_morphology0.83250512
110MP0000462_abnormal_digestive_system0.81506462
111MP0005409_darkened_coat_color0.81211421
112MP0010678_abnormal_skin_adnexa0.80360197
113MP0002233_abnormal_nose_morphology0.77952570
114MP0001348_abnormal_lacrimal_gland0.77937843
115* MP0002081_perinatal_lethality0.77921002
116MP0002114_abnormal_axial_skeleton0.77836144
117MP0008789_abnormal_olfactory_epithelium0.77797286
118MP0005501_abnormal_skin_physiology0.77715591
119MP0003943_abnormal_hepatobiliary_system0.77468388
120MP0000477_abnormal_intestine_morphology0.77130416
121MP0000534_abnormal_ureter_morphology0.76787724
122MP0003221_abnormal_cardiomyocyte_apopto0.76006656
123MP0003315_abnormal_perineum_morphology0.75816698
124MP0000689_abnormal_spleen_morphology0.75603848
125MP0002152_abnormal_brain_morphology0.74813797
126MP0004858_abnormal_nervous_system0.71960454
127MP0004133_heterotaxia0.71741444
128MP0005499_abnormal_olfactory_system0.71367007
129MP0005394_taste/olfaction_phenotype0.71367007
130MP0000631_abnormal_neuroendocrine_gland0.70557217
131MP0002210_abnormal_sex_determination0.70360725

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)3.75488064
2Hyperacusis (HP:0010780)3.63444567
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.42070591
4Short 4th metacarpal (HP:0010044)3.42070591
5Volvulus (HP:0002580)3.37874675
6Increased nuchal translucency (HP:0010880)3.28307125
7Cortical dysplasia (HP:0002539)3.11526355
8Renal duplication (HP:0000075)3.08743354
9Subacute progressive viral hepatitis (HP:0006572)2.82177206
10Abnormality of cells of the erythroid lineage (HP:0012130)2.80352172
11Proximal placement of thumb (HP:0009623)2.76064758
12Selective tooth agenesis (HP:0001592)2.71837467
13Shallow orbits (HP:0000586)2.69522897
14Increased density of long bones (HP:0006392)2.65625370
15Abnormality of the 4th metacarpal (HP:0010012)2.64574252
16Deviation of the thumb (HP:0009603)2.64102589
17Overriding aorta (HP:0002623)2.63619099
18Chromosomal breakage induced by crosslinking agents (HP:0003221)2.63403866
19Chromsome breakage (HP:0040012)2.62073032
20Partial duplication of thumb phalanx (HP:0009944)2.60400657
21Elfin facies (HP:0004428)2.57129522
22Septo-optic dysplasia (HP:0100842)2.54865622
23Colon cancer (HP:0003003)2.49540090
24Partial duplication of the phalanx of hand (HP:0009999)2.48914927
25Macrocytic anemia (HP:0001972)2.45680837
26Acute lymphatic leukemia (HP:0006721)2.42617177
27Birth length less than 3rd percentile (HP:0003561)2.39631783
28Abnormality of the fingertips (HP:0001211)2.36449606
29Renovascular hypertension (HP:0100817)2.35400827
30Abnormal number of incisors (HP:0011064)2.34745243
31Nephroblastoma (Wilms tumor) (HP:0002667)2.31987982
32Duplication of thumb phalanx (HP:0009942)2.29178810
33Macroorchidism (HP:0000053)2.24326586
34Broad palm (HP:0001169)2.23949903
35Abnormal number of erythroid precursors (HP:0012131)2.21399818
36Heterotopia (HP:0002282)2.19950676
37Bowel diverticulosis (HP:0005222)2.18880424
38Aplasia/Hypoplasia of the sacrum (HP:0008517)2.18855690
39Pointed chin (HP:0000307)2.18708291
4011 pairs of ribs (HP:0000878)2.18403210
41Ependymoma (HP:0002888)2.16970208
42Trigonocephaly (HP:0000243)2.16092760
43Abnormality of the astrocytes (HP:0100707)2.15352455
44Astrocytoma (HP:0009592)2.15352455
45Insomnia (HP:0100785)2.12625808
46Medulloblastoma (HP:0002885)2.11851152
47Abnormal lung lobation (HP:0002101)2.11540482
48Embryonal renal neoplasm (HP:0011794)2.10343686
49Sacral dimple (HP:0000960)2.10155562
50Abnormality of the distal phalanx of the thumb (HP:0009617)2.09966632
51Broad distal phalanx of finger (HP:0009836)2.09496381
52Flat cornea (HP:0007720)2.08540134
53Cutis marmorata (HP:0000965)2.07758563
54Obsessive-compulsive behavior (HP:0000722)2.05537438
55Arnold-Chiari malformation (HP:0002308)2.04103874
56Pallor (HP:0000980)2.04037663
57Pelvic girdle muscle weakness (HP:0003749)2.03902260
58Viral hepatitis (HP:0006562)2.02575031
59Deviation of the hallux (HP:0010051)2.01614876
60Hallux valgus (HP:0001822)2.01144624
61Long eyelashes (HP:0000527)2.00917523
62Abnormality of the calcaneus (HP:0008364)1.99736450
63Prominent nose (HP:0000448)1.98320382
64Turricephaly (HP:0000262)1.98220163
65Deep palmar crease (HP:0006191)1.98080394
66Malignant gastrointestinal tract tumors (HP:0006749)1.97798172
67Gastrointestinal carcinoma (HP:0002672)1.97798172
68High pitched voice (HP:0001620)1.97403644
69Abnormality of the parietal bone (HP:0002696)1.96524102
70Bilateral microphthalmos (HP:0007633)1.96380145
71Long palpebral fissure (HP:0000637)1.93969750
72Multiple enchondromatosis (HP:0005701)1.93681884
73Pseudobulbar signs (HP:0002200)1.93062824
74Facial hemangioma (HP:0000329)1.91483620
75Abnormality of cochlea (HP:0000375)1.89690275
76Abnormality of the phalanges of the hallux (HP:0010057)1.89498509
77Coronal craniosynostosis (HP:0004440)1.89192869
78Maternal diabetes (HP:0009800)1.87522156
79Disproportionate tall stature (HP:0001519)1.86895351
80Broad thumb (HP:0011304)1.85406602
81Atresia of the external auditory canal (HP:0000413)1.84771605
82Shoulder girdle muscle weakness (HP:0003547)1.84515551
83Breast hypoplasia (HP:0003187)1.83902608
84Megalocornea (HP:0000485)1.83017346
85Protrusio acetabuli (HP:0003179)1.81290057
86Deep philtrum (HP:0002002)1.81105943
87Generalized hypotonia (HP:0001290)1.80791703
88Overlapping toe (HP:0001845)1.80189260
89Fibrous tissue neoplasm (HP:0012316)1.79541177
90Abnormality of the septum pellucidum (HP:0007375)1.79405226
91Esophageal atresia (HP:0002032)1.78332943
92Asymmetry of the thorax (HP:0001555)1.78184629
93Abnormality of the diencephalon (HP:0010662)1.78061594
94Triphalangeal thumb (HP:0001199)1.76658228
95Absent septum pellucidum (HP:0001331)1.76581326
96Bicuspid aortic valve (HP:0001647)1.75476865
97Broad finger (HP:0001500)1.74932643
98Basal cell carcinoma (HP:0002671)1.74209540
99Abnormality of reticulocytes (HP:0004312)1.74060962
100Urethral obstruction (HP:0000796)1.73446061
101Abnormality of the lacrimal duct (HP:0011481)1.73127291
102Skin tags (HP:0010609)1.72958525
103Cerebral aneurysm (HP:0004944)1.72642637
104Bladder diverticulum (HP:0000015)1.72319827
105Hepatoblastoma (HP:0002884)1.72151100
106Abnormality of the labia minora (HP:0012880)1.71875642
107Abnormality of the hip-girdle musculature (HP:0001445)1.71177205
108Abnormality of the musculature of the pelvis (HP:0001469)1.71177205
109Spastic diplegia (HP:0001264)1.70765768
110Ankyloglossia (HP:0010296)1.70640819
111Neoplasm of the oral cavity (HP:0100649)1.70454263
112Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.69767777
113Fibroma (HP:0010614)1.69534151
114Uterine leiomyosarcoma (HP:0002891)1.68613422
115Leiomyosarcoma (HP:0100243)1.68613422
116Hemivertebrae (HP:0002937)1.68376259
117Supernumerary ribs (HP:0005815)1.67565569
118Transitional cell carcinoma of the bladder (HP:0006740)1.66836662
119Germ cell neoplasia (HP:0100728)1.66380051
120Abnormality of oral frenula (HP:0000190)1.66261790
121Insidious onset (HP:0003587)1.65945203
122Termporal pattern (HP:0011008)1.65945203
123Morphological abnormality of the inner ear (HP:0011390)1.65199520
124Thin ribs (HP:0000883)1.65196166
125Shawl scrotum (HP:0000049)1.64054591
126Rectal prolapse (HP:0002035)1.64010088
127Genu recurvatum (HP:0002816)1.63552373
128Myelomeningocele (HP:0002475)1.62848382
129Facial cleft (HP:0002006)1.62590269
130Midline defect of the nose (HP:0004122)1.62241780
131Truncal obesity (HP:0001956)1.61134262
132Patellar aplasia (HP:0006443)1.61128744
133Missing ribs (HP:0000921)1.61105391
134Vertebral arch anomaly (HP:0008438)1.60654486
135Glossoptosis (HP:0000162)1.60494170
136Radioulnar synostosis (HP:0002974)1.60283444
137Choanal stenosis (HP:0000452)1.60212181
138Broad phalanges of the hand (HP:0009768)1.60059103
139Enlarged penis (HP:0000040)1.60050445
140Spina bifida occulta (HP:0003298)1.59989349
141Narrow palate (HP:0000189)1.59569025
142Dislocated radial head (HP:0003083)1.59362181
143High anterior hairline (HP:0009890)1.59005965
144Abnormality of the radial head (HP:0003995)1.58379710
145Skull defect (HP:0001362)1.58241923
146Glioma (HP:0009733)1.57730659
147Abnormality of chromosome segregation (HP:0002916)1.56863969
148Exostoses (HP:0100777)1.55837426
149Syringomyelia (HP:0003396)1.55692220
150Spinal cord lesions (HP:0100561)1.55692220
151Mitral valve prolapse (HP:0001634)1.54753301
152Disinhibition (HP:0000734)1.52555633
153Aplasia/Hypoplasia of the sternum (HP:0006714)1.52145059
154Preauricular skin tag (HP:0000384)1.51880651
155Bladder neoplasm (HP:0009725)1.51757583
156Bladder carcinoma (HP:0002862)1.51757583
157Low anterior hairline (HP:0000294)1.51346603
158Thick eyebrow (HP:0000574)1.50597387
159Ulnar bowing (HP:0003031)1.50549010
160Ectopic kidney (HP:0000086)1.49822295
161Patellar dislocation (HP:0002999)1.49354168
162Somatic mutation (HP:0001428)1.49079163
163Persistence of primary teeth (HP:0006335)1.48571754

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.91759006
2MAP3K103.66968136
3CDC73.64964245
4SMG13.44977702
5PKN23.06948040
6TRIB32.89221943
7CDK122.75027338
8TAF12.63352242
9VRK22.52766054
10PNCK2.32480536
11NEK22.32124699
12STK102.24859532
13ALK2.06166914
14STK32.03871158
15MKNK11.94435151
16LRRK21.73803483
17PASK1.60927730
18RPS6KB21.60783516
19PRPF4B1.60120467
20WEE11.57359396
21CDK41.56034145
22ICK1.54199818
23SRPK11.50595704
24DYRK31.47447205
25PDGFRA1.46901651
26CDK61.46263724
27MAP4K11.42695843
28RPS6KA41.40466725
29SCYL21.39937629
30MKNK21.36993493
31PLK41.34797466
32NME21.33948868
33TTK1.32543516
34TGFBR11.29368364
35PAK41.29320973
36MAP3K81.28936308
37TYRO31.24743465
38BRD41.23513561
39ATR1.22985412
40TESK21.21849982
41ACVR1B1.21546438
42SIK21.18772207
43BUB11.14091720
44FGFR11.13316612
45DMPK1.09998408
46CHEK11.08989479
47MTOR1.07743965
48PBK1.06754338
49LATS11.05577522
50RIPK11.03458261
51TSSK61.02897255
52LATS20.96342890
53CDK70.95756118
54PAK20.93754047
55FGFR30.93695907
56VRK10.91613352
57SIK10.89950847
58NEK10.89058582
59FGFR20.88069971
60MAP3K90.87998439
61DYRK20.86789695
62CLK10.86619628
63TNIK0.82144391
64PLK30.81603566
65AURKB0.81568571
66PLK10.81422664
67* CDK20.81295619
68* PTK60.79989020
69KSR10.78762455
70GRK60.78347994
71EIF2AK10.77784558
72PDGFRB0.77373651
73AURKA0.76305612
74TTN0.74054893
75BMX0.73430950
76ATM0.71450491
77CDK150.69797815
78STK160.69159434
79UHMK10.68998175
80JAK30.68651509
81STK240.67838883
82CDK180.65786752
83CSNK1A1L0.65050828
84BRAF0.64444053
85BRSK20.63640883
86CASK0.63550857
87HIPK20.61506039
88ILK0.61139763
89EIF2AK20.60715246
90MELK0.60220646
91ITK0.59982377
92CDK190.59694968
93BTK0.58007004
94RET0.57664267
95NTRK10.57477588
96CDK80.57391599
97* CDK10.56722630
98FGFR40.56620514
99CDK30.55952509
100MARK10.54679643
101CDK90.54662663
102PIM10.53480467
103NME10.53459115
104KSR20.53290474
105FLT30.52319700
106EPHB20.49801965
107CHEK20.49703816
108DDR20.47924217
109LIMK10.47600614
110CSNK1G30.47575088
111STK40.46500801
112CSNK1D0.46383475
113CSNK1E0.46082350
114CSNK2A20.46032519
115CAMK1G0.45933970
116ZAP700.45846024
117* PRKDC0.45347081
118BRSK10.44962429
119ERBB20.44316658
120CDK140.42474788
121MAPK90.41636428
122AKT20.40913773
123* MAPK140.40167011
124TESK10.38525682
125HCK0.38100303
126RPS6KA10.37977145
127PTK20.37484489
128CDK11A0.37438924
129CAMK1D0.36930385
130* GSK3B0.36565527
131AKT10.34979845
132IRAK30.34544568

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.46384041
2Spliceosome_Homo sapiens_hsa030402.39987182
3Cell cycle_Homo sapiens_hsa041102.28383572
4RNA transport_Homo sapiens_hsa030131.98372631
5mRNA surveillance pathway_Homo sapiens_hsa030151.93786274
6Chronic myeloid leukemia_Homo sapiens_hsa052201.87819701
7Colorectal cancer_Homo sapiens_hsa052101.79724306
8Mismatch repair_Homo sapiens_hsa034301.74415181
9MicroRNAs in cancer_Homo sapiens_hsa052061.56954889
10Base excision repair_Homo sapiens_hsa034101.49976903
11Basal cell carcinoma_Homo sapiens_hsa052171.47066122
12Endometrial cancer_Homo sapiens_hsa052131.45113407
13Small cell lung cancer_Homo sapiens_hsa052221.42307339
14Hippo signaling pathway_Homo sapiens_hsa043901.41170972
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34713008
16HTLV-I infection_Homo sapiens_hsa051661.33851683
17Viral myocarditis_Homo sapiens_hsa054161.31870413
18Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.30695376
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29679149
20Non-small cell lung cancer_Homo sapiens_hsa052231.29651891
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.29203040
22Biosynthesis of amino acids_Homo sapiens_hsa012301.28372267
23Viral carcinogenesis_Homo sapiens_hsa052031.27909705
24T cell receptor signaling pathway_Homo sapiens_hsa046601.27354833
25Pancreatic cancer_Homo sapiens_hsa052121.26892367
26Notch signaling pathway_Homo sapiens_hsa043301.26118706
27B cell receptor signaling pathway_Homo sapiens_hsa046621.26072480
28Primary immunodeficiency_Homo sapiens_hsa053401.24716604
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24323805
30Antigen processing and presentation_Homo sapiens_hsa046121.23898821
31Neurotrophin signaling pathway_Homo sapiens_hsa047221.21755859
32Acute myeloid leukemia_Homo sapiens_hsa052211.20287952
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.19351457
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.18671844
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.18448929
36p53 signaling pathway_Homo sapiens_hsa041151.17559808
37Proteoglycans in cancer_Homo sapiens_hsa052051.16564381
38Oocyte meiosis_Homo sapiens_hsa041141.16292013
39RNA polymerase_Homo sapiens_hsa030201.15092102
40Basal transcription factors_Homo sapiens_hsa030221.11932670
41One carbon pool by folate_Homo sapiens_hsa006701.11284449
42Nucleotide excision repair_Homo sapiens_hsa034201.09470874
43mTOR signaling pathway_Homo sapiens_hsa041501.08764634
44Hepatitis B_Homo sapiens_hsa051611.08601238
45Transcriptional misregulation in cancer_Homo sapiens_hsa052021.08263917
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.07916129
47Pyrimidine metabolism_Homo sapiens_hsa002401.07331029
48Adherens junction_Homo sapiens_hsa045201.07150972
49Glioma_Homo sapiens_hsa052141.06842041
50Epstein-Barr virus infection_Homo sapiens_hsa051691.06502331
51Renal cell carcinoma_Homo sapiens_hsa052111.05936456
52Herpes simplex infection_Homo sapiens_hsa051681.05738916
53Hedgehog signaling pathway_Homo sapiens_hsa043401.04980275
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01313185
55Wnt signaling pathway_Homo sapiens_hsa043101.00339335
56Thyroid cancer_Homo sapiens_hsa052160.99931763
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98623102
58VEGF signaling pathway_Homo sapiens_hsa043700.97666138
59Homologous recombination_Homo sapiens_hsa034400.96743331
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.95936888
61Pathways in cancer_Homo sapiens_hsa052000.95550477
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95465464
63Shigellosis_Homo sapiens_hsa051310.94145988
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92452237
65Prostate cancer_Homo sapiens_hsa052150.91675760
66RNA degradation_Homo sapiens_hsa030180.89552093
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89329902
68Non-homologous end-joining_Homo sapiens_hsa034500.88750138
69TGF-beta signaling pathway_Homo sapiens_hsa043500.86994091
70Apoptosis_Homo sapiens_hsa042100.86706367
71Fanconi anemia pathway_Homo sapiens_hsa034600.86685624
72Focal adhesion_Homo sapiens_hsa045100.86600849
73Pentose phosphate pathway_Homo sapiens_hsa000300.86068921
74Toxoplasmosis_Homo sapiens_hsa051450.84937696
75Measles_Homo sapiens_hsa051620.83034140
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.81385362
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.80623022
78Osteoclast differentiation_Homo sapiens_hsa043800.79481433
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.79441283
80Prolactin signaling pathway_Homo sapiens_hsa049170.78937182
81Bladder cancer_Homo sapiens_hsa052190.78676855
82Ribosome_Homo sapiens_hsa030100.77767071
83Estrogen signaling pathway_Homo sapiens_hsa049150.77529574
84Dorso-ventral axis formation_Homo sapiens_hsa043200.76898722
85ErbB signaling pathway_Homo sapiens_hsa040120.75577874
86Platelet activation_Homo sapiens_hsa046110.75384569
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74216169
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73413260
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72958800
90Carbon metabolism_Homo sapiens_hsa012000.71796349
91FoxO signaling pathway_Homo sapiens_hsa040680.71501753
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71114486
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70913714
94Leishmaniasis_Homo sapiens_hsa051400.69653284
95Axon guidance_Homo sapiens_hsa043600.69149482
96Chemokine signaling pathway_Homo sapiens_hsa040620.68854364
97Lysine degradation_Homo sapiens_hsa003100.67727866
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63824106
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63694581
100TNF signaling pathway_Homo sapiens_hsa046680.62248575
101MAPK signaling pathway_Homo sapiens_hsa040100.61931264
102Prion diseases_Homo sapiens_hsa050200.61402187
103Rap1 signaling pathway_Homo sapiens_hsa040150.61062650
104Endocytosis_Homo sapiens_hsa041440.58947215
105Gap junction_Homo sapiens_hsa045400.58766545
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.58478528
107Melanogenesis_Homo sapiens_hsa049160.57477973
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54682027
109Alcoholism_Homo sapiens_hsa050340.54560759
110Proteasome_Homo sapiens_hsa030500.54127471
111HIF-1 signaling pathway_Homo sapiens_hsa040660.53614658
112Choline metabolism in cancer_Homo sapiens_hsa052310.53292535
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.53058072
114Melanoma_Homo sapiens_hsa052180.52619146
115Steroid biosynthesis_Homo sapiens_hsa001000.52311469
116Tight junction_Homo sapiens_hsa045300.52092414
117Influenza A_Homo sapiens_hsa051640.51190479
118Selenocompound metabolism_Homo sapiens_hsa004500.51119457
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50337403
120Purine metabolism_Homo sapiens_hsa002300.49186912
121Pyruvate metabolism_Homo sapiens_hsa006200.45497229
122Huntingtons disease_Homo sapiens_hsa050160.44650430
123Insulin signaling pathway_Homo sapiens_hsa049100.43317122
124AMPK signaling pathway_Homo sapiens_hsa041520.39532310
125Folate biosynthesis_Homo sapiens_hsa007900.38944499
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38775565
127Protein export_Homo sapiens_hsa030600.38436266
1282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36787700
129Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36567144
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34987948

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