KHDRBS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.58532596
2vocalization behavior (GO:0071625)5.24986946
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.22849478
4synaptic vesicle exocytosis (GO:0016079)5.22762111
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.10643811
6synaptic vesicle maturation (GO:0016188)5.04216786
7glutamate secretion (GO:0014047)5.02254341
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.02165823
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.00717547
10protein localization to synapse (GO:0035418)4.90276972
11locomotory exploration behavior (GO:0035641)4.81884177
12regulation of synaptic vesicle exocytosis (GO:2000300)4.73085596
13regulation of glutamate receptor signaling pathway (GO:1900449)4.68188803
14neuron cell-cell adhesion (GO:0007158)4.65066680
15layer formation in cerebral cortex (GO:0021819)4.43325192
16regulation of synaptic vesicle transport (GO:1902803)4.28749636
17neurofilament cytoskeleton organization (GO:0060052)4.24701195
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.18529187
19exploration behavior (GO:0035640)4.11777087
20neuronal ion channel clustering (GO:0045161)4.06125290
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.05523348
22positive regulation of synapse maturation (GO:0090129)4.05188259
23neuron recognition (GO:0008038)4.05040748
24pyrimidine nucleobase catabolic process (GO:0006208)3.95483567
25regulation of long-term neuronal synaptic plasticity (GO:0048169)3.94377161
26regulation of neuronal synaptic plasticity (GO:0048168)3.93829800
27neurotransmitter secretion (GO:0007269)3.92703246
28neurotransmitter-gated ion channel clustering (GO:0072578)3.88972029
29dendritic spine morphogenesis (GO:0060997)3.87759907
30glutamate receptor signaling pathway (GO:0007215)3.85113139
31synaptic transmission, glutamatergic (GO:0035249)3.78362502
32regulation of synapse structural plasticity (GO:0051823)3.76053100
33axonal fasciculation (GO:0007413)3.68908675
34proline transport (GO:0015824)3.67603093
35neuron-neuron synaptic transmission (GO:0007270)3.60309501
36regulation of dendritic spine morphogenesis (GO:0061001)3.58123052
37neuronal action potential propagation (GO:0019227)3.55697202
38synaptic vesicle endocytosis (GO:0048488)3.52584274
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.51709270
40regulation of excitatory postsynaptic membrane potential (GO:0060079)3.49866025
41innervation (GO:0060384)3.49288527
42axon ensheathment in central nervous system (GO:0032291)3.42656087
43central nervous system myelination (GO:0022010)3.42656087
44postsynaptic membrane organization (GO:0001941)3.42543321
45cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.39473062
46regulation of postsynaptic membrane potential (GO:0060078)3.37693147
47activation of protein kinase A activity (GO:0034199)3.36140689
48positive regulation of membrane potential (GO:0045838)3.35665820
49regulation of synaptic plasticity (GO:0048167)3.33268887
50establishment of mitochondrion localization (GO:0051654)3.33209487
51long-term memory (GO:0007616)3.31404665
52long-term synaptic potentiation (GO:0060291)3.29500736
53detection of calcium ion (GO:0005513)3.29023176
54positive regulation of dendritic spine morphogenesis (GO:0061003)3.28288564
55cell migration in hindbrain (GO:0021535)3.27341968
56nucleobase catabolic process (GO:0046113)3.27336718
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.26621680
58cell communication by electrical coupling (GO:0010644)3.25957132
59gamma-aminobutyric acid signaling pathway (GO:0007214)3.25811939
60presynaptic membrane assembly (GO:0097105)3.24906478
61neurotransmitter transport (GO:0006836)3.21055927
62regulation of neurotransmitter secretion (GO:0046928)3.18917592
63axon extension (GO:0048675)3.16947680
64G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.15141328
65dendrite morphogenesis (GO:0048813)3.13376882
66auditory behavior (GO:0031223)3.12195982
67regulation of synapse maturation (GO:0090128)3.08023903
68dendritic spine organization (GO:0097061)3.07732126
69positive regulation of neurotransmitter secretion (GO:0001956)3.07676800
70behavioral response to nicotine (GO:0035095)3.07384070
71cellular potassium ion homeostasis (GO:0030007)3.06990861
72negative regulation of synaptic transmission, GABAergic (GO:0032229)3.06674097
73behavioral fear response (GO:0001662)3.05105779
74behavioral defense response (GO:0002209)3.05105779
75positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.02176439
76gamma-aminobutyric acid transport (GO:0015812)3.01803169
77mitochondrion transport along microtubule (GO:0047497)3.01100104
78establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.01100104
79adult walking behavior (GO:0007628)3.00852610
80positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.99508633
81G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.98340181
82regulation of dendritic spine development (GO:0060998)2.98027322
83vesicle transport along microtubule (GO:0047496)2.96903473
84regulation of synaptic transmission, glutamatergic (GO:0051966)2.96106068
85neuromuscular synaptic transmission (GO:0007274)2.96009067
86regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.94147350
87regulation of vesicle fusion (GO:0031338)2.92901340
88presynaptic membrane organization (GO:0097090)2.91959578
89positive regulation of dendritic spine development (GO:0060999)2.91600158
90fear response (GO:0042596)2.91292846
91synapse assembly (GO:0007416)2.89561686
92mechanosensory behavior (GO:0007638)2.89346437
93transmission of nerve impulse (GO:0019226)2.85393866
94organelle transport along microtubule (GO:0072384)2.83910055
95central nervous system projection neuron axonogenesis (GO:0021952)2.83563900
96regulation of neurotransmitter transport (GO:0051588)2.83360155
97membrane depolarization (GO:0051899)2.83141763
98regulation of neurotransmitter levels (GO:0001505)2.82968903
99membrane depolarization during action potential (GO:0086010)2.82738213
100positive regulation of neurotransmitter transport (GO:0051590)2.81812978
101sodium ion export (GO:0071436)2.81179012
102chemosensory behavior (GO:0007635)2.80191454
103learning (GO:0007612)2.80070249
104synapse organization (GO:0050808)2.79804610
105neuromuscular process controlling balance (GO:0050885)2.79617114
106regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.79463171
107regulation of female receptivity (GO:0045924)2.77901374
108positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.77559154
109retinal ganglion cell axon guidance (GO:0031290)2.75646725
110regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.75635209
111axon cargo transport (GO:0008088)2.75556314
112substrate-independent telencephalic tangential migration (GO:0021826)2.75497509
113substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.75497509
114response to histamine (GO:0034776)2.75399265
115long term synaptic depression (GO:0060292)2.75202386
116cochlea development (GO:0090102)2.74925879
117neuron projection extension (GO:1990138)2.74824683
118intraspecies interaction between organisms (GO:0051703)2.73789574
119social behavior (GO:0035176)2.73789574
120synaptic transmission (GO:0007268)2.72846481
121negative regulation of axon extension (GO:0030517)2.72745869
122regulation of synaptic transmission (GO:0050804)2.71394390
123cerebellar Purkinje cell differentiation (GO:0021702)2.69288004
124behavioral response to cocaine (GO:0048148)2.68870197
125positive regulation of synapse assembly (GO:0051965)2.68555682
126negative regulation of axonogenesis (GO:0050771)2.68395591
127response to auditory stimulus (GO:0010996)2.66220038
128calcium ion-dependent exocytosis (GO:0017156)2.57082493
129multicellular organismal signaling (GO:0035637)2.56771042
130cerebellar granule cell differentiation (GO:0021707)2.54820255
131protein polyglutamylation (GO:0018095)2.51701858
132L-amino acid import (GO:0043092)2.51230263
133negative regulation of dendrite development (GO:2000171)2.49078679
134negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.48526708

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.18207169
2GBX2_23144817_ChIP-Seq_PC3_Human3.58681334
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95149931
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89215477
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.80640374
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.71621240
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54893358
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54893358
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.50984158
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.47925964
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44352325
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.43295067
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35334408
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.34930649
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33756737
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31094774
17DROSHA_22980978_ChIP-Seq_HELA_Human2.25578485
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25387814
19* REST_18959480_ChIP-ChIP_MESCs_Mouse2.19456867
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.14742071
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13772507
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.13284429
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.12412540
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.11508831
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.95706982
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94576456
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92054739
28* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85610022
29* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81859374
30SMAD4_21799915_ChIP-Seq_A2780_Human1.65380099
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64844561
32ZNF274_21170338_ChIP-Seq_K562_Hela1.62505741
33TAF15_26573619_Chip-Seq_HEK293_Human1.62388859
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60969982
35AR_21572438_ChIP-Seq_LNCaP_Human1.58690194
36GATA1_26923725_Chip-Seq_HPCs_Mouse1.52668624
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48538493
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47672571
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.47590726
40* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44238606
41P300_19829295_ChIP-Seq_ESCs_Human1.39384833
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.38579750
43* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36117888
44* RING1B_27294783_Chip-Seq_ESCs_Mouse1.35823500
45* SOX2_21211035_ChIP-Seq_LN229_Gbm1.35174089
46NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34259280
47* SMAD3_21741376_ChIP-Seq_EPCs_Human1.33245854
48* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32751057
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32441999
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31500572
51RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30704180
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30115342
53TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27689204
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27645369
55ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25498866
56AR_19668381_ChIP-Seq_PC3_Human1.23502039
57RING1B_27294783_Chip-Seq_NPCs_Mouse1.23447084
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22466806
59* AR_25329375_ChIP-Seq_VCAP_Human1.21934223
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21742541
61STAT3_23295773_ChIP-Seq_U87_Human1.20218776
62* PIAS1_25552417_ChIP-Seq_VCAP_Human1.18143503
63* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17500012
64RNF2_27304074_Chip-Seq_NSC_Mouse1.16859533
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16207031
66* FUS_26573619_Chip-Seq_HEK293_Human1.15875745
67VDR_22108803_ChIP-Seq_LS180_Human1.15804388
68* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14341180
69* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13716387
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12517931
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11994191
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11369485
73* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11307745
74IGF1R_20145208_ChIP-Seq_DFB_Human1.11281798
75KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11246533
76YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11179577
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11137020
78POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10366001
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.10284307
80ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09862667
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09136940
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08962037
83OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07802684
84* TCF4_23295773_ChIP-Seq_U87_Human1.07789414
85TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06087571
86P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06061532
87* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05732192
88* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05428960
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04592923
90TP53_20018659_ChIP-ChIP_R1E_Mouse1.03795413
91RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03607821
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03471662
93AHR_22903824_ChIP-Seq_MCF-7_Human1.00566836
94SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00124161
95DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99129751
96BCAT_22108803_ChIP-Seq_LS180_Human0.98639133
97EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98387554
98* SMAD3_21741376_ChIP-Seq_ESCs_Human0.97912005
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97314485
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97314485
101* SMAD4_21741376_ChIP-Seq_HESCs_Human0.97155054
102SALL1_21062744_ChIP-ChIP_HESCs_Human0.96928745
103* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96677822
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95399371
105KDM2B_26808549_Chip-Seq_K562_Human0.95135095
106CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94676614
107* RUNX2_22187159_ChIP-Seq_PCA_Human0.93721574
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93328461
109CBP_20019798_ChIP-Seq_JUKART_Human0.92921796
110IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92921796
111FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92638179
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92320253
113* SOX9_26525672_Chip-Seq_HEART_Mouse0.91844121
114CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90863062
115* SMAD3_21741376_ChIP-Seq_HESCs_Human0.90666664
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90589697
117POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90248084
118RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89494351
119* PRDM14_20953172_ChIP-Seq_ESCs_Human0.89009132
120* JUN_21703547_ChIP-Seq_K562_Human0.87551316
121BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.87513531

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.00039350
2MP0003880_abnormal_central_pattern4.95400514
3MP0003635_abnormal_synaptic_transmissio3.81137778
4MP0004270_analgesia3.76981206
5MP0002063_abnormal_learning/memory/cond3.22391499
6MP0009745_abnormal_behavioral_response2.98659422
7MP0002064_seizures2.73049314
8MP0003123_paternal_imprinting2.71212860
9MP0001968_abnormal_touch/_nociception2.65243915
10MP0002572_abnormal_emotion/affect_behav2.56549750
11MP0002734_abnormal_mechanical_nocicepti2.43710227
12MP0009046_muscle_twitch2.34757085
13MP0009780_abnormal_chondrocyte_physiolo2.32054542
14MP0001486_abnormal_startle_reflex2.21714290
15MP0002272_abnormal_nervous_system2.17547528
16MP0005423_abnormal_somatic_nervous2.15736427
17MP0000778_abnormal_nervous_system2.12721463
18MP0002736_abnormal_nociception_after2.09720031
19MP0002837_dystrophic_cardiac_calcinosis2.07123741
20MP0001440_abnormal_grooming_behavior1.96507191
21MP0001984_abnormal_olfaction1.92371317
22MP0002909_abnormal_adrenal_gland1.91429898
23MP0002735_abnormal_chemical_nociception1.84437398
24MP0002184_abnormal_innervation1.80872116
25MP0001501_abnormal_sleep_pattern1.77154640
26MP0002067_abnormal_sensory_capabilities1.74520829
27MP0003890_abnormal_embryonic-extraembry1.70218065
28MP0004811_abnormal_neuron_physiology1.69656682
29MP0002733_abnormal_thermal_nociception1.69382426
30MP0002557_abnormal_social/conspecific_i1.66909632
31MP0006276_abnormal_autonomic_nervous1.65057450
32MP0004858_abnormal_nervous_system1.64787063
33MP0008877_abnormal_DNA_methylation1.63897653
34MP0001970_abnormal_pain_threshold1.61199927
35MP0003329_amyloid_beta_deposits1.59337342
36MP0002822_catalepsy1.57330600
37MP0000955_abnormal_spinal_cord1.57184980
38MP0003787_abnormal_imprinting1.57123010
39MP0004924_abnormal_behavior1.46695115
40MP0005386_behavior/neurological_phenoty1.46695115
41MP0005551_abnormal_eye_electrophysiolog1.44602210
42MP0002882_abnormal_neuron_morphology1.44564987
43MP0005646_abnormal_pituitary_gland1.38588926
44MP0000751_myopathy1.36338979
45MP0003122_maternal_imprinting1.36151634
46MP0003879_abnormal_hair_cell1.35170332
47MP0008569_lethality_at_weaning1.33566466
48MP0009379_abnormal_foot_pigmentation1.30257314
49MP0002066_abnormal_motor_capabilities/c1.29013819
50MP0001502_abnormal_circadian_rhythm1.28713633
51MP0004215_abnormal_myocardial_fiber1.27032887
52MP0004885_abnormal_endolymph1.25834565
53MP0004133_heterotaxia1.25832998
54MP0002152_abnormal_brain_morphology1.19908559
55MP0005645_abnormal_hypothalamus_physiol1.19285290
56MP0004145_abnormal_muscle_electrophysio1.15834469
57MP0004233_abnormal_muscle_weight1.14797616
58MP0005394_taste/olfaction_phenotype1.13892847
59MP0005499_abnormal_olfactory_system1.13892847
60MP0004085_abnormal_heartbeat1.12885359
61MP0003633_abnormal_nervous_system1.11940916
62MP0003283_abnormal_digestive_organ1.06900700
63MP0005623_abnormal_meninges_morphology1.03110731
64MP0006072_abnormal_retinal_apoptosis1.01800703
65MP0001188_hyperpigmentation1.01681003
66MP0000569_abnormal_digit_pigmentation1.01467897
67MP0005187_abnormal_penis_morphology0.99812225
68MP0003137_abnormal_impulse_conducting0.99457410
69MP0010386_abnormal_urinary_bladder0.98910932
70MP0002234_abnormal_pharynx_morphology0.97383503
71MP0000631_abnormal_neuroendocrine_gland0.97079135
72MP0000013_abnormal_adipose_tissue0.95348717
73MP0002160_abnormal_reproductive_system0.95089888
74MP0002069_abnormal_eating/drinking_beha0.93657025
75MP0002229_neurodegeneration0.93115824
76MP0001529_abnormal_vocalization0.92107899
77MP0004484_altered_response_of0.91306704
78MP0003631_nervous_system_phenotype0.91264534
79MP0008961_abnormal_basal_metabolism0.89192353
80MP0001299_abnormal_eye_distance/0.88727001
81MP0004142_abnormal_muscle_tone0.88243481
82MP0002752_abnormal_somatic_nervous0.87047995
83MP0001905_abnormal_dopamine_level0.85839455
84MP0002090_abnormal_vision0.84057804
85MP0000026_abnormal_inner_ear0.83833930
86MP0002653_abnormal_ependyma_morphology0.83820160
87MP0005535_abnormal_body_temperature0.83125041
88MP0000534_abnormal_ureter_morphology0.80529803
89MP0003861_abnormal_nervous_system0.78909308
90MP0004130_abnormal_muscle_cell0.77514494
91MP0003136_yellow_coat_color0.75319962
92MP0003119_abnormal_digestive_system0.74451942
93MP0004043_abnormal_pH_regulation0.74107761
94MP0005620_abnormal_muscle_contractility0.73943419
95MP0003942_abnormal_urinary_system0.73907923
96MP0003634_abnormal_glial_cell0.73701705
97MP0001293_anophthalmia0.72696780
98MP0005253_abnormal_eye_physiology0.72080055
99MP0003690_abnormal_glial_cell0.71278728
100MP0001963_abnormal_hearing_physiology0.71133690
101MP0004036_abnormal_muscle_relaxation0.70367967
102MP0001986_abnormal_taste_sensitivity0.69225393
103MP0004084_abnormal_cardiac_muscle0.69024652
104MP0006292_abnormal_olfactory_placode0.68462699
105MP0002638_abnormal_pupillary_reflex0.66601981
106MP0003698_abnormal_male_reproductive0.65685894
107MP0002938_white_spotting0.65424881
108MP0003938_abnormal_ear_development0.65184535
109MP0008874_decreased_physiological_sensi0.64709186
110MP0003646_muscle_fatigue0.63917310
111MP0004742_abnormal_vestibular_system0.62607761
112MP0002081_perinatal_lethality0.62586441
113MP0003385_abnormal_body_wall0.62354353
114MP0002210_abnormal_sex_determination0.62081089
115MP0002876_abnormal_thyroid_physiology0.60881865
116MP0003632_abnormal_nervous_system0.60593552
117MP0008789_abnormal_olfactory_epithelium0.59774938
118MP0001177_atelectasis0.58730755
119MP0005195_abnormal_posterior_eye0.58332558
120MP0008872_abnormal_physiological_respon0.57590036
121MP0002972_abnormal_cardiac_muscle0.57498834
122MP0001485_abnormal_pinna_reflex0.56509273
123MP0003121_genomic_imprinting0.56249937

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.55436148
2Myokymia (HP:0002411)5.23779461
3Visual hallucinations (HP:0002367)4.91695998
4Focal seizures (HP:0007359)4.85332023
5Epileptic encephalopathy (HP:0200134)4.79087523
6Atonic seizures (HP:0010819)4.16313716
7Hyperventilation (HP:0002883)4.05409209
8Febrile seizures (HP:0002373)3.94084779
9Absence seizures (HP:0002121)3.90007481
10Dialeptic seizures (HP:0011146)3.52993565
11Generalized tonic-clonic seizures (HP:0002069)3.42145822
12Progressive cerebellar ataxia (HP:0002073)3.37992069
13Supranuclear gaze palsy (HP:0000605)3.34790422
14Abnormality of the lower motor neuron (HP:0002366)3.26406411
15Amblyopia (HP:0000646)3.22395055
16Broad-based gait (HP:0002136)3.08133483
17Impaired vibration sensation in the lower limbs (HP:0002166)3.02734028
18Poor eye contact (HP:0000817)2.98096104
19Depression (HP:0000716)2.93038577
20Epileptiform EEG discharges (HP:0011182)2.91255140
21Excessive salivation (HP:0003781)2.88415818
22Drooling (HP:0002307)2.88415818
23EEG with generalized epileptiform discharges (HP:0011198)2.77357448
24Action tremor (HP:0002345)2.75710549
25Abnormal social behavior (HP:0012433)2.73314961
26Impaired social interactions (HP:0000735)2.73314961
27Dysdiadochokinesis (HP:0002075)2.72079237
28Anxiety (HP:0000739)2.70171264
29Cerebral inclusion bodies (HP:0100314)2.64575892
30Hypsarrhythmia (HP:0002521)2.61038353
31Degeneration of the lateral corticospinal tracts (HP:0002314)2.50499438
32Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.50499438
33Urinary bladder sphincter dysfunction (HP:0002839)2.49371992
34Insidious onset (HP:0003587)2.48702436
35Termporal pattern (HP:0011008)2.48702436
36Amyotrophic lateral sclerosis (HP:0007354)2.48575047
37Ankle clonus (HP:0011448)2.48013192
38Gaze-evoked nystagmus (HP:0000640)2.47586903
39Hemiparesis (HP:0001269)2.43114884
40Truncal ataxia (HP:0002078)2.38082076
41Dysmetria (HP:0001310)2.37057082
42Mutism (HP:0002300)2.33505542
43Postural instability (HP:0002172)2.30842265
44Genetic anticipation (HP:0003743)2.28981731
45Pheochromocytoma (HP:0002666)2.28543278
46Cerebral hypomyelination (HP:0006808)2.27991188
47Sudden death (HP:0001699)2.25769913
48Urinary urgency (HP:0000012)2.24986230
49Central scotoma (HP:0000603)2.24137197
50Absent speech (HP:0001344)2.23157547
51Oligodactyly (hands) (HP:0001180)2.22218847
52Papilledema (HP:0001085)2.19616374
53Gait imbalance (HP:0002141)2.18503289
54Impaired smooth pursuit (HP:0007772)2.18065611
55Megalencephaly (HP:0001355)2.17785307
56Agitation (HP:0000713)2.17252266
57Abnormal eating behavior (HP:0100738)2.15700515
58Abnormality of the labia minora (HP:0012880)2.15635306
59Neurofibrillary tangles (HP:0002185)2.13607914
60Bradykinesia (HP:0002067)2.12566922
61Abnormality of the corticospinal tract (HP:0002492)2.11944755
62Spastic tetraplegia (HP:0002510)2.05960860
63Ventricular fibrillation (HP:0001663)2.05240447
64Status epilepticus (HP:0002133)2.04862734
65Impaired vibratory sensation (HP:0002495)2.04756238
66Inability to walk (HP:0002540)2.02176975
67Progressive inability to walk (HP:0002505)2.00673069
68Syncope (HP:0001279)2.00251385
69Poor suck (HP:0002033)1.97995308
70Sleep apnea (HP:0010535)1.96684811
71Double outlet right ventricle (HP:0001719)1.94464555
72Congenital malformation of the right heart (HP:0011723)1.94464555
73Generalized myoclonic seizures (HP:0002123)1.94340204
74Absent/shortened dynein arms (HP:0200106)1.94314397
75Dynein arm defect of respiratory motile cilia (HP:0012255)1.94314397
76Torticollis (HP:0000473)1.93971767
77Increased circulating renin level (HP:0000848)1.93912764
78Hyperthyroidism (HP:0000836)1.93377560
79Hypomagnesemia (HP:0002917)1.93290223
80Neuroendocrine neoplasm (HP:0100634)1.93095083
81Genital tract atresia (HP:0001827)1.92861345
82Spastic gait (HP:0002064)1.92082904
83Lower limb muscle weakness (HP:0007340)1.91657054
84Focal dystonia (HP:0004373)1.90812125
85Abnormality of ocular smooth pursuit (HP:0000617)1.90300924
86Stereotypic behavior (HP:0000733)1.89215677
87Dysmetric saccades (HP:0000641)1.87500297
88Abnormality of binocular vision (HP:0011514)1.87092198
89Diplopia (HP:0000651)1.87092198
90Hepatoblastoma (HP:0002884)1.86652107
91Pachygyria (HP:0001302)1.86069247
92Vaginal atresia (HP:0000148)1.84976137
93Incomplete penetrance (HP:0003829)1.84601625
94Morphological abnormality of the pyramidal tract (HP:0002062)1.84416638
95Abnormality of magnesium homeostasis (HP:0004921)1.84009792
96Nephronophthisis (HP:0000090)1.83945086
97Medial flaring of the eyebrow (HP:0010747)1.83449342
98Progressive macrocephaly (HP:0004481)1.83442059
99Exotropia (HP:0000577)1.83161076
100Protruding tongue (HP:0010808)1.82388361
101Abnormal EKG (HP:0003115)1.82238294
102Fetal akinesia sequence (HP:0001989)1.81856745
103Insomnia (HP:0100785)1.81404023
104Rapidly progressive (HP:0003678)1.81190347
105Abnormal pancreas size (HP:0012094)1.81146396
106Abnormality of midbrain morphology (HP:0002418)1.80582722
107Molar tooth sign on MRI (HP:0002419)1.80582722
108Bundle branch block (HP:0011710)1.80311892
109Retinal dysplasia (HP:0007973)1.79715379
110Abnormality of macular pigmentation (HP:0008002)1.77782922
111Delusions (HP:0000746)1.77206911
112Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.77194252
113Intention tremor (HP:0002080)1.77192265
114Abnormality of salivation (HP:0100755)1.77002887
115Polyphagia (HP:0002591)1.75414918
116Prolonged QT interval (HP:0001657)1.75170821
117Specific learning disability (HP:0001328)1.75069289
118Acute necrotizing encephalopathy (HP:0006965)1.72628222
119Volvulus (HP:0002580)1.72534108
120Lissencephaly (HP:0001339)1.72448837
121Intellectual disability, profound (HP:0002187)1.72193751
122Limb dystonia (HP:0002451)1.71649763
123Neoplasm of the peripheral nervous system (HP:0100007)1.69671113
124Gait ataxia (HP:0002066)1.68943361
125Hypoplasia of the brainstem (HP:0002365)1.68734991
126Aplasia/Hypoplasia of the brainstem (HP:0007362)1.68734991
127Resting tremor (HP:0002322)1.67260152
128Congenital primary aphakia (HP:0007707)1.67183581
129Scanning speech (HP:0002168)1.66987926
130Inappropriate behavior (HP:0000719)1.66729905
131Type II lissencephaly (HP:0007260)1.65980771
132Neoplasm of the adrenal cortex (HP:0100641)1.65091260
133Craniofacial dystonia (HP:0012179)1.62636228
134Optic nerve hypoplasia (HP:0000609)1.61019168
135Metaphyseal dysplasia (HP:0100255)1.59713838
136CNS hypomyelination (HP:0003429)1.59558597
137Nephrogenic diabetes insipidus (HP:0009806)1.58911934
138Spastic tetraparesis (HP:0001285)1.58295680
139Pancreatic fibrosis (HP:0100732)1.57889749

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.23301023
2NTRK33.82324432
3MARK13.82009983
4MAP3K93.57676771
5MAP3K43.14694354
6DAPK22.57333641
7MINK12.56618166
8CASK2.49675864
9MAP2K72.49137350
10PRKD32.26492102
11PAK62.13513206
12MAP2K42.02395630
13PNCK1.80482114
14KSR21.78093398
15KSR11.73997924
16NTRK21.71613175
17STK391.70865234
18PLK21.70387912
19DAPK11.69443082
20RIPK41.60518552
21GRK51.56874465
22NTRK11.54413621
23PHKG21.44689512
24PHKG11.44689512
25SIK21.42557801
26MAP3K121.42437503
27CDK51.42116981
28CAMKK11.38649345
29PRKCG1.21818638
30MAPK131.20705761
31LATS21.19103109
32UHMK11.17941864
33PDK31.17612284
34PDK41.17612284
35PRPF4B1.16949858
36STK381.16027920
37BRAF1.14523892
38TYRO31.12860038
39MAP3K21.10721876
40PKN11.07896896
41PTK2B1.05937281
42CAMK2A1.03933562
43CDK191.03218822
44PAK31.02665124
45STK160.99012151
46TRIM280.88128760
47PINK10.85960838
48ARAF0.82911791
49LIMK10.82288465
50DYRK1A0.82014063
51STK110.81669923
52CDK180.81243566
53RET0.81203616
54DYRK30.80239366
55CDK140.80033799
56CAMK2B0.79854636
57CDK150.79830749
58BCR0.78579436
59FRK0.78096281
60NME10.76720223
61MAP3K60.75380790
62CCNB10.73469061
63SGK2230.72512421
64SGK4940.72512421
65CSNK1E0.70956704
66TNIK0.69719381
67BMPR20.69371257
68ZAK0.69008587
69OBSCN0.68459252
70NEK10.67694030
71CDK11A0.67356847
72CAMK10.66780445
73BMPR1B0.66031105
74CSNK1G20.64703110
75CAMK2G0.64638040
76FER0.64321591
77MKNK20.59708777
78CAMK1G0.59382844
79PRKG10.59056889
80AKT30.58964944
81WNK30.58781539
82RAF10.57829683
83EPHB20.57245029
84DMPK0.56979634
85ADRBK20.56827261
86FGR0.56496764
87CAMK2D0.56068409
88STK38L0.56047537
89PRKCZ0.55927729
90SGK10.55848021
91WNK10.54422677
92PDK10.53703834
93MARK20.53632153
94TAOK10.53118440
95FES0.52342818
96INSRR0.52086266
97PRKCE0.51404309
98FGFR20.51143940
99OXSR10.50933109
100SGK20.50328509
101LMTK20.49810533
102CAMKK20.48918351
103PRKCH0.48422544
104PDPK10.46698718
105PRKACA0.46560148
106ERBB30.45721644
107CDC42BPA0.45383733
108ABL20.44911303
109MAP3K70.44662119
110PLK40.44481009
111ICK0.44128838
112RPS6KA30.43662953
113PDK20.43600328
114MAP3K130.43439526
115PLK30.43288748
116PBK0.42805653
117CAMK40.41495297
118DAPK30.41494810
119ROCK10.39973890
120SGK30.39407706
121MAPK100.39224296
122MAP2K10.37521525
123WNK40.37503571
124DYRK20.37231842
125MAPK120.37153986
126ROCK20.37095671
127PLK10.36824907
128GSK3B0.35462528
129MAP3K10.35135569
130PRKDC0.34839089
131CSNK1A10.34713378
132ALK0.33464516
133CSNK1G30.32697136
134CSNK1G10.32556934
135BRSK10.32413304

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.39602615
2Synaptic vesicle cycle_Homo sapiens_hsa047213.11219676
3Olfactory transduction_Homo sapiens_hsa047402.72893164
4Long-term potentiation_Homo sapiens_hsa047202.64744238
5Circadian entrainment_Homo sapiens_hsa047132.64456049
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.60182367
7GABAergic synapse_Homo sapiens_hsa047272.51993797
8Amphetamine addiction_Homo sapiens_hsa050312.42252328
9Glutamatergic synapse_Homo sapiens_hsa047242.40538352
10Morphine addiction_Homo sapiens_hsa050322.32187617
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.29785102
12Insulin secretion_Homo sapiens_hsa049112.21015573
13Dopaminergic synapse_Homo sapiens_hsa047282.17952257
14Salivary secretion_Homo sapiens_hsa049702.00104913
15Renin secretion_Homo sapiens_hsa049241.81394459
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78709096
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.77376430
18Cholinergic synapse_Homo sapiens_hsa047251.77364780
19Gastric acid secretion_Homo sapiens_hsa049711.76045393
20Taste transduction_Homo sapiens_hsa047421.73082485
21Oxytocin signaling pathway_Homo sapiens_hsa049211.65078712
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.56603308
23Serotonergic synapse_Homo sapiens_hsa047261.53228437
24Parkinsons disease_Homo sapiens_hsa050121.52900126
25Calcium signaling pathway_Homo sapiens_hsa040201.50702401
26Long-term depression_Homo sapiens_hsa047301.48449027
27Collecting duct acid secretion_Homo sapiens_hsa049661.43781242
28Phototransduction_Homo sapiens_hsa047441.43426739
29GnRH signaling pathway_Homo sapiens_hsa049121.37643430
30Cocaine addiction_Homo sapiens_hsa050301.36265271
31Gap junction_Homo sapiens_hsa045401.32951945
32Cardiac muscle contraction_Homo sapiens_hsa042601.28081656
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.27814339
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21910922
35Axon guidance_Homo sapiens_hsa043601.21204327
36Type II diabetes mellitus_Homo sapiens_hsa049301.19740845
37Estrogen signaling pathway_Homo sapiens_hsa049151.18981682
38cAMP signaling pathway_Homo sapiens_hsa040241.18364184
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17445738
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14842187
41Glioma_Homo sapiens_hsa052141.14432466
42Melanogenesis_Homo sapiens_hsa049161.11584321
43Huntingtons disease_Homo sapiens_hsa050161.07227475
44Glucagon signaling pathway_Homo sapiens_hsa049221.00952832
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99984952
46Vibrio cholerae infection_Homo sapiens_hsa051100.99439881
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98166794
48ErbB signaling pathway_Homo sapiens_hsa040120.96203979
49Dilated cardiomyopathy_Homo sapiens_hsa054140.95438041
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.93666770
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.93490300
52Vitamin B6 metabolism_Homo sapiens_hsa007500.93238533
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91623477
54Oocyte meiosis_Homo sapiens_hsa041140.89980463
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88446586
56Nitrogen metabolism_Homo sapiens_hsa009100.85002283
57Hippo signaling pathway_Homo sapiens_hsa043900.80821517
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77223176
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74898750
60Dorso-ventral axis formation_Homo sapiens_hsa043200.73978938
61Thyroid hormone synthesis_Homo sapiens_hsa049180.72232303
62Hedgehog signaling pathway_Homo sapiens_hsa043400.70486339
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70394542
64Pancreatic secretion_Homo sapiens_hsa049720.68899479
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68603392
66Circadian rhythm_Homo sapiens_hsa047100.66694267
67Arginine and proline metabolism_Homo sapiens_hsa003300.65161753
68mTOR signaling pathway_Homo sapiens_hsa041500.64635213
69VEGF signaling pathway_Homo sapiens_hsa043700.64218403
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63925288
71Protein export_Homo sapiens_hsa030600.63603320
72Choline metabolism in cancer_Homo sapiens_hsa052310.62099129
73Alzheimers disease_Homo sapiens_hsa050100.62033007
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61821670
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.60203109
76Regulation of autophagy_Homo sapiens_hsa041400.59555739
77Wnt signaling pathway_Homo sapiens_hsa043100.58102726
78Tight junction_Homo sapiens_hsa045300.57952065
79MAPK signaling pathway_Homo sapiens_hsa040100.57412378
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56789829
81Bile secretion_Homo sapiens_hsa049760.56450187
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56006189
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55988287
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55441949
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55326251
86Insulin signaling pathway_Homo sapiens_hsa049100.55087044
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54514103
88Basal cell carcinoma_Homo sapiens_hsa052170.53946883
89Steroid biosynthesis_Homo sapiens_hsa001000.53560356
90Folate biosynthesis_Homo sapiens_hsa007900.53274377
91beta-Alanine metabolism_Homo sapiens_hsa004100.53041803
92Basal transcription factors_Homo sapiens_hsa030220.52736377
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52180499
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51152090
95Ras signaling pathway_Homo sapiens_hsa040140.51081301
96Endometrial cancer_Homo sapiens_hsa052130.50794297
97Alcoholism_Homo sapiens_hsa050340.49843961
98Rap1 signaling pathway_Homo sapiens_hsa040150.48642269
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47780220
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.47173481
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46806215
102Prion diseases_Homo sapiens_hsa050200.46058091
103Butanoate metabolism_Homo sapiens_hsa006500.45278358
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44740215
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44027693
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43429350
1072-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42835852
108Renal cell carcinoma_Homo sapiens_hsa052110.42153553
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41532848
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41075938
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41034508
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39684208
113Oxidative phosphorylation_Homo sapiens_hsa001900.38654908
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38058399
115Inositol phosphate metabolism_Homo sapiens_hsa005620.37241884
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.36711482
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.33775328
118Melanoma_Homo sapiens_hsa052180.33563115
119AMPK signaling pathway_Homo sapiens_hsa041520.33133956
120Fatty acid biosynthesis_Homo sapiens_hsa000610.32788402
121Non-small cell lung cancer_Homo sapiens_hsa052230.32339491
122Ovarian steroidogenesis_Homo sapiens_hsa049130.31182182
123Arginine biosynthesis_Homo sapiens_hsa002200.30350073
124Colorectal cancer_Homo sapiens_hsa052100.29353477
125Pyruvate metabolism_Homo sapiens_hsa006200.24925697

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