KHK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)8.46957011
2L-phenylalanine catabolic process (GO:0006559)7.38729805
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.38729805
4L-phenylalanine metabolic process (GO:0006558)7.17461933
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.17461933
6angiotensin maturation (GO:0002003)6.92397262
7aromatic amino acid family catabolic process (GO:0009074)6.82112117
8regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.38727179
9indole-containing compound catabolic process (GO:0042436)6.29383457
10indolalkylamine catabolic process (GO:0046218)6.29383457
11tryptophan catabolic process (GO:0006569)6.29383457
12fat-soluble vitamin biosynthetic process (GO:0042362)6.22474955
13drug metabolic process (GO:0017144)6.20821787
14glyoxylate metabolic process (GO:0046487)6.13029232
15kynurenine metabolic process (GO:0070189)5.99835600
16tryptophan metabolic process (GO:0006568)5.90791294
17NADH metabolic process (GO:0006734)5.85627271
18triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.81868619
19cysteine metabolic process (GO:0006534)5.76197271
20omega-hydroxylase P450 pathway (GO:0097267)5.69796141
21very-low-density lipoprotein particle assembly (GO:0034379)5.66234433
22bile acid biosynthetic process (GO:0006699)5.64807027
23lysine metabolic process (GO:0006553)5.46852373
24lysine catabolic process (GO:0006554)5.46852373
25alpha-linolenic acid metabolic process (GO:0036109)5.33661019
26sulfur amino acid catabolic process (GO:0000098)5.29978640
27serine family amino acid catabolic process (GO:0009071)5.21609249
28urea metabolic process (GO:0019627)5.18322820
29urea cycle (GO:0000050)5.18322820
30fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.15811636
31intestinal absorption (GO:0050892)5.13481994
32high-density lipoprotein particle remodeling (GO:0034375)5.02182001
33hormone catabolic process (GO:0042447)5.01717212
34aromatic amino acid family metabolic process (GO:0009072)4.97182006
35homocysteine metabolic process (GO:0050667)4.85296414
36negative regulation of fibrinolysis (GO:0051918)4.83563274
37nitrogen cycle metabolic process (GO:0071941)4.80823549
38bile acid metabolic process (GO:0008206)4.79536416
39peptidyl-glutamic acid carboxylation (GO:0017187)4.79058602
40protein carboxylation (GO:0018214)4.79058602
41amino-acid betaine metabolic process (GO:0006577)4.78837626
42cellular ketone body metabolic process (GO:0046950)4.69154250
43complement activation, alternative pathway (GO:0006957)4.65399000
44alpha-amino acid catabolic process (GO:1901606)4.65134306
45drug transmembrane transport (GO:0006855)4.64052667
46regulation of fibrinolysis (GO:0051917)4.61390544
47alkaloid metabolic process (GO:0009820)4.59722465
48urate metabolic process (GO:0046415)4.58342584
49regulation of protein activation cascade (GO:2000257)4.58212432
50regulation of triglyceride catabolic process (GO:0010896)4.53481790
51regulation of cholesterol esterification (GO:0010872)4.52566021
52protein-lipid complex assembly (GO:0065005)4.52313751
53lipoprotein transport (GO:0042953)4.50639289
54tyrosine metabolic process (GO:0006570)4.50108992
55proline metabolic process (GO:0006560)4.44900186
56negative regulation of cholesterol transport (GO:0032375)4.44396320
57negative regulation of sterol transport (GO:0032372)4.44396320
58indolalkylamine metabolic process (GO:0006586)4.43977149
59serine family amino acid metabolic process (GO:0009069)4.41925185
60drug catabolic process (GO:0042737)4.40640689
61reverse cholesterol transport (GO:0043691)4.36934577
62cellular amino acid catabolic process (GO:0009063)4.35978107
63amine catabolic process (GO:0009310)4.34683460
64cellular biogenic amine catabolic process (GO:0042402)4.34683460
65glutamate metabolic process (GO:0006536)4.32533134
66diacylglycerol metabolic process (GO:0046339)4.31534012
67plasma lipoprotein particle remodeling (GO:0034369)4.29590453
68protein-lipid complex remodeling (GO:0034368)4.29590453
69macromolecular complex remodeling (GO:0034367)4.29590453
70regulation of complement activation (GO:0030449)4.27811159
71cellular modified amino acid catabolic process (GO:0042219)4.27654141
72phospholipid efflux (GO:0033700)4.26782669
73acylglycerol homeostasis (GO:0055090)4.26532042
74triglyceride homeostasis (GO:0070328)4.26532042
75glycine metabolic process (GO:0006544)4.25532609
76cellular glucuronidation (GO:0052695)4.25344002
77benzene-containing compound metabolic process (GO:0042537)4.23618341
78short-chain fatty acid metabolic process (GO:0046459)4.21894995
79regulation of guanylate cyclase activity (GO:0031282)4.17283757
80coenzyme catabolic process (GO:0009109)4.15087562
81bile acid and bile salt transport (GO:0015721)4.14706365
82serine family amino acid biosynthetic process (GO:0009070)4.13918071
83ethanol oxidation (GO:0006069)4.13210844
84plasma lipoprotein particle organization (GO:0071827)4.12399464
85ethanol metabolic process (GO:0006067)4.10630155
86aldehyde catabolic process (GO:0046185)4.06920078
87ketone body metabolic process (GO:1902224)4.05535621
88blood coagulation, intrinsic pathway (GO:0007597)4.03997331
89phenylpropanoid metabolic process (GO:0009698)4.01728602
90glutamine family amino acid biosynthetic process (GO:0009084)4.00939564
91lipoprotein metabolic process (GO:0042157)3.98784242
92drug transport (GO:0015893)3.94224016
93oxidative demethylation (GO:0070989)3.92355304
94aspartate family amino acid catabolic process (GO:0009068)3.90356935
95plasma lipoprotein particle clearance (GO:0034381)3.90306023
96protein-lipid complex subunit organization (GO:0071825)3.89913470
97imidazole-containing compound metabolic process (GO:0052803)3.89093424
98glucuronate metabolic process (GO:0019585)3.88881300
99uronic acid metabolic process (GO:0006063)3.88881300
100organic acid catabolic process (GO:0016054)3.88136018
101carboxylic acid catabolic process (GO:0046395)3.88136018
102complement activation, classical pathway (GO:0006958)3.87065400
103acetyl-CoA metabolic process (GO:0006084)3.86902335
104positive regulation of fatty acid biosynthetic process (GO:0045723)3.86733251
105fibrinolysis (GO:0042730)3.86075395
106dicarboxylic acid biosynthetic process (GO:0043650)3.82912675
1072-oxoglutarate metabolic process (GO:0006103)3.81949502
108positive regulation of lipid catabolic process (GO:0050996)3.81678192
109arginine metabolic process (GO:0006525)3.80911157
110exogenous drug catabolic process (GO:0042738)3.80660811
111* fructose metabolic process (GO:0006000)3.74733870
112cholesterol efflux (GO:0033344)3.74374484
113flavonoid metabolic process (GO:0009812)3.73046000
114negative regulation of blood coagulation (GO:0030195)3.72643198
115negative regulation of hemostasis (GO:1900047)3.72643198
116fatty acid beta-oxidation (GO:0006635)3.72513260
117fatty acid oxidation (GO:0019395)3.71437767
118protein activation cascade (GO:0072376)3.68460390
119carnitine metabolic process (GO:0009437)3.67517384
120vitamin biosynthetic process (GO:0009110)3.67061144
121positive regulation of triglyceride lipase activity (GO:0061365)3.66453743
122positive regulation of lipoprotein lipase activity (GO:0051006)3.66453743
123regulation of cholesterol homeostasis (GO:2000188)3.65308533
124regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.64941284
125endocrine process (GO:0050886)3.64941284
126regulation of systemic arterial blood pressure by hormone (GO:0001990)3.64941284
127plasma lipoprotein particle assembly (GO:0034377)3.64671440
128lipid oxidation (GO:0034440)3.64237634
129monocarboxylic acid catabolic process (GO:0072329)3.63731473
130regulation of bile acid biosynthetic process (GO:0070857)3.62196174
131oxaloacetate metabolic process (GO:0006107)3.61337522
132valine metabolic process (GO:0006573)3.58828640
133complement activation (GO:0006956)3.56793021
134cholesterol homeostasis (GO:0042632)3.56438901
135acute-phase response (GO:0006953)3.55344452
136nicotinamide nucleotide biosynthetic process (GO:0019359)3.55099869
137pyridine nucleotide biosynthetic process (GO:0019363)3.55099869
138low-density lipoprotein particle remodeling (GO:0034374)3.55080812
139NAD biosynthetic process (GO:0009435)3.54829413
140response to nitrosative stress (GO:0051409)3.54437165
141heme transport (GO:0015886)3.53440490
142renal system process involved in regulation of blood volume (GO:0001977)3.52834672
143regulation of plasminogen activation (GO:0010755)3.51544814
144proline biosynthetic process (GO:0006561)3.51316842
145sterol homeostasis (GO:0055092)3.50235666
146renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.49378366
147intestinal cholesterol absorption (GO:0030299)3.41917812
148negative regulation of coagulation (GO:0050819)3.41633463
149L-ascorbic acid metabolic process (GO:0019852)3.34862380

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.21772226
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.10299380
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.68020900
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.26347590
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.19946827
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.91798259
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.90413623
8* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.89819392
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.76935947
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.39158201
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27942003
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.17228150
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.05978666
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.04106899
15* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.5265173
16SRY_22984422_ChIP-ChIP_TESTIS_Rat1.67913586
17CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.57343485
18CLOCK_20551151_ChIP-Seq_293T_Human1.54368092
19GATA1_22025678_ChIP-Seq_K562_Human1.54144320
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.53021784
21* FOXA2_19822575_ChIP-Seq_HepG2_Human1.47796852
22* HNF4A_19822575_ChIP-Seq_HepG2_Human1.44220879
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42580070
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39464596
25SA1_27219007_Chip-Seq_Bcells_Human1.33514283
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33246031
27IRF8_22096565_ChIP-ChIP_GC-B_Human1.31787303
28BCL6_27268052_Chip-Seq_Bcells_Human1.30225341
29HTT_18923047_ChIP-ChIP_STHdh_Human1.26556395
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25482588
31CTCF_27219007_Chip-Seq_Bcells_Human1.21033874
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20520676
33RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19002741
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16091169
35* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14938430
36ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13946952
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13696112
38* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10228558
39JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.09190430
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.08437275
41ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08117225
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06955067
43OCT4_18692474_ChIP-Seq_MEFs_Mouse1.04739163
44P68_20966046_ChIP-Seq_HELA_Human1.04251168
45GATA4_25053715_ChIP-Seq_YYC3_Human1.02554331
46AR_21909140_ChIP-Seq_LNCAP_Human0.98941186
47PHF8_20622854_ChIP-Seq_HELA_Human0.97188512
48E2F1_20622854_ChIP-Seq_HELA_Human0.95653402
49CTCF_20526341_ChIP-Seq_ESCs_Human0.95478408
50KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94557628
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93657432
52SOX2_21211035_ChIP-Seq_LN229_Human0.93268553
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90852632
54SMC4_20622854_ChIP-Seq_HELA_Human0.90208154
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89913980
56KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.89733785
57ETS1_21867929_ChIP-Seq_TH2_Mouse0.89465664
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87569534
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.87099942
60* SA1_27219007_Chip-Seq_ERYTHROID_Human0.86499239
61SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.84205502
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.83361645
63GATA3_21867929_ChIP-Seq_CD8_Mouse0.83087059
64EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.81586097
65CREB1_26743006_Chip-Seq_LNCaP_Human0.81022576
66CDX2_20551321_ChIP-Seq_CACO-2_Human0.81016163
67NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.80654357
68CTCF_27219007_Chip-Seq_ERYTHROID_Human0.79923807
69SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.79903639
70KAP1_22055183_ChIP-Seq_ESCs_Mouse0.79648328
71SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.79138985
72ELK3_25401928_ChIP-Seq_HUVEC_Human0.79123956
73P300_27268052_Chip-Seq_Bcells_Human0.79055787
74YY1_22570637_ChIP-Seq_MALME-3M_Human0.78591659
75ESR2_21235772_ChIP-Seq_MCF-7_Human0.78475446
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77917835
77VDR_21846776_ChIP-Seq_THP-1_Human0.77588876
78* SOX2_22085726_ChIP-Seq_NPCs_Mouse0.77582497
79TP63_17297297_ChIP-ChIP_HaCaT_Human0.77033165
80ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76758842
81Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.76529791
82NANOG_20526341_ChIP-Seq_ESCs_Human0.76486551
83BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.76233212
84AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76217348
85STAT3_1855785_ChIP-Seq_MESCs_Mouse0.76160692
86LXR_22292898_ChIP-Seq_THP-1_Human0.75996176
87ESR1_21235772_ChIP-Seq_MCF-7_Human0.75870890
88ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.75325117
89RARA_24833708_ChIP-Seq_LIVER_Mouse0.75073772
90GATA2_22383799_ChIP-Seq_G1ME_Mouse0.74571178
91LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.74543176
92RAD21_21589869_ChIP-Seq_MESCs_Mouse0.72144057
93CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70574306
94EGR1_19032775_ChIP-ChIP_M12_Human0.68428364
95AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66401468
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.65736811
97ZNF263_19887448_ChIP-Seq_K562_Human0.64795468
98* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.63876437
99AR_20517297_ChIP-Seq_VCAP_Human0.63056496
100GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.62205208
101CEBPB_22108803_ChIP-Seq_LS180_Human0.61212986
102* GATA1_19941827_ChIP-Seq_MEL_Mouse0.60845915
103* RARB_24833708_ChIP-Seq_LIVER_Mouse0.60238041
104SALL4_18804426_ChIP-ChIP_XEN_Mouse0.58569481
105GATA6_25053715_ChIP-Seq_YYC3_Human0.58051895
106MYC_19915707_ChIP-ChIP_AK7_Human0.57518288
107ESET_19884257_ChIP-Seq_ESCs_Mouse0.55257217
108GATA2_19941826_ChIP-Seq_K562_Human0.53796748
109PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52394310
110RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.52389095
111PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.51711622
112FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51136385
113* TAF2_19829295_ChIP-Seq_ESCs_Human0.50950985
114NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.50944735
115NRF2_20460467_ChIP-Seq_MEFs_Mouse0.50944735
116STAT1_17558387_ChIP-Seq_HELA_Human0.50634779
117GATA1_19941826_ChIP-Seq_K562_Human0.49504875
118FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.48750990
119* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.48583790
120PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.48059070
121FOXA1_25552417_ChIP-Seq_VCAP_Human0.47844816
122SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.47452589
123P53_21459846_ChIP-Seq_SAOS-2_Human0.46958164
124SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.45192733
125BCOR_27268052_Chip-Seq_Bcells_Human0.45179425
126CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.45115207
127SOX2_20726797_ChIP-Seq_SW620_Human0.44812057
128PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44612678
129TET1_21451524_ChIP-Seq_MESCs_Mouse0.44415943
130RACK7_27058665_Chip-Seq_MCF-7_Human0.43188283
131FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.43181218
132PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.42598939
133FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.42484566
134CBP_21632823_ChIP-Seq_H3396_Human0.42292255
135FOXO3_23340844_ChIP-Seq_DLD1_Human0.41935516
136LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.41838165
137BRD4_27068464_Chip-Seq_AML-cells_Mouse0.41376815
138GATA1_22383799_ChIP-Seq_G1ME_Mouse0.41233545
139ERG_20517297_ChIP-Seq_VCAP_Human0.40518087
140PPAR_26484153_Chip-Seq_NCI-H1993_Human0.40323949
141RAC3_21632823_ChIP-Seq_H3396_Human0.40051673
142STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.39338750

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.10173239
2MP0005360_urolithiasis8.03170318
3MP0005085_abnormal_gallbladder_physiolo5.94463117
4MP0005365_abnormal_bile_salt5.80179270
5MP0008875_abnormal_xenobiotic_pharmacok4.97892840
6MP0003806_abnormal_nucleotide_metabolis4.07683677
7MP0003252_abnormal_bile_duct3.75259959
8MP0010329_abnormal_lipoprotein_level3.30181571
9MP0005332_abnormal_amino_acid3.21018447
10MP0009840_abnormal_foam_cell3.11000079
11MP0003195_calcinosis3.05870596
12MP0005083_abnormal_biliary_tract2.70470689
13MP0004019_abnormal_vitamin_homeostasis2.67371229
14MP0001666_abnormal_nutrient_absorption2.65852819
15MP0003183_abnormal_peptide_metabolism2.57489108
16MP0003191_abnormal_cellular_cholesterol2.37804543
17MP0002138_abnormal_hepatobiliary_system2.24522488
18MP0000609_abnormal_liver_physiology2.02327971
19MP0009379_abnormal_foot_pigmentation2.00571023
20MP0002118_abnormal_lipid_homeostasis1.99986432
21MP0005319_abnormal_enzyme/_coenzyme1.86764894
22MP0009643_abnormal_urine_homeostasis1.81016531
23MP0001764_abnormal_homeostasis1.74329665
24MP0005584_abnormal_enzyme/coenzyme_acti1.67788098
25MP0003868_abnormal_feces_composition1.66696378
26MP0003186_abnormal_redox_activity1.51703894
27MP0010155_abnormal_intestine_physiology1.45639487
28MP0003879_abnormal_hair_cell1.41907267
29MP0005451_abnormal_body_composition1.41607236
30MP0005636_abnormal_mineral_homeostasis1.39762435
31MP0000678_abnormal_parathyroid_gland1.33970863
32MP0009697_abnormal_copulation1.31159990
33MP0005409_darkened_coat_color1.29027522
34MP0004043_abnormal_pH_regulation1.18393274
35MP0003656_abnormal_erythrocyte_physiolo1.17965387
36MP0000598_abnormal_liver_morphology1.14556254
37MP0003011_delayed_dark_adaptation1.13951275
38MP0010234_abnormal_vibrissa_follicle1.09047343
39MP0009764_decreased_sensitivity_to1.08129239
40MP0001756_abnormal_urination1.04892728
41MP0006036_abnormal_mitochondrial_physio1.03753116
42MP0005647_abnormal_sex_gland0.98257646
43MP0005084_abnormal_gallbladder_morpholo0.97627533
44MP0008469_abnormal_protein_level0.97450754
45MP0001664_abnormal_digestion0.97278140
46MP0002876_abnormal_thyroid_physiology0.95914256
47MP0003866_abnormal_defecation0.93374494
48MP0009642_abnormal_blood_homeostasis0.93079500
49MP0009763_increased_sensitivity_to0.92864908
50MP0000604_amyloidosis0.92356749
51MP0002136_abnormal_kidney_physiology0.91579596
52MP0003705_abnormal_hypodermis_morpholog0.87474049
53MP0000490_abnormal_crypts_of0.85113852
54MP0005408_hypopigmentation0.80333107
55MP0005376_homeostasis/metabolism_phenot0.77666880
56MP0001765_abnormal_ion_homeostasis0.77431955
57MP0000477_abnormal_intestine_morphology0.77296053
58MP0002078_abnormal_glucose_homeostasis0.76776154
59MP0009765_abnormal_xenobiotic_induced0.75825349
60MP0000566_synostosis0.75050035
61MP0005220_abnormal_exocrine_pancreas0.74479075
62MP0005535_abnormal_body_temperature0.74356375
63MP0002254_reproductive_system_inflammat0.73737933
64MP0005670_abnormal_white_adipose0.73565373
65MP0010368_abnormal_lymphatic_system0.70036871
66MP0005058_abnormal_lysosome_morphology0.67836956
67MP0002971_abnormal_brown_adipose0.64648305
68MP0005266_abnormal_metabolism0.63682381
69MP0005334_abnormal_fat_pad0.63388642
70MP0004270_analgesia0.63240163
71MP0002249_abnormal_larynx_morphology0.62610968
72MP0006035_abnormal_mitochondrial_morpho0.61925677
73MP0001661_extended_life_span0.60746921
74MP0005464_abnormal_platelet_physiology0.60160674
75MP0003724_increased_susceptibility_to0.60052419
76MP0003638_abnormal_response/metabolism_0.59344821
77MP0002928_abnormal_bile_duct0.58083313
78MP0000462_abnormal_digestive_system0.57220387
79MP0004858_abnormal_nervous_system0.55175456
80MP0001188_hyperpigmentation0.54773473
81MP0003329_amyloid_beta_deposits0.52791229
82MP0003690_abnormal_glial_cell0.52576658
83MP0001663_abnormal_digestive_system0.51026048
84MP0004130_abnormal_muscle_cell0.50742082
85MP0002089_abnormal_postnatal_growth/wei0.48848730
86MP0010352_gastrointestinal_tract_polyps0.48766986
87MP0009053_abnormal_anal_canal0.48231363
88MP0004147_increased_porphyrin_level0.47892536
89MP0005395_other_phenotype0.47606005
90MP0005448_abnormal_energy_balance0.47228727
91MP0003436_decreased_susceptibility_to0.47183728
92MP0000230_abnormal_systemic_arterial0.46745135
93MP0003075_altered_response_to0.45718505
94MP0004264_abnormal_extraembryonic_tissu0.45381671
95MP0000538_abnormal_urinary_bladder0.44938843
96MP0008873_increased_physiological_sensi0.44142801
97MP0003953_abnormal_hormone_level0.43986484
98MP0009333_abnormal_splenocyte_physiolog0.42895227
99MP0005166_decreased_susceptibility_to0.42292339
100MP0001501_abnormal_sleep_pattern0.41931075
101MP0000639_abnormal_adrenal_gland0.41511747
102MP0009785_altered_susceptibility_to0.41431318
103MP0001845_abnormal_inflammatory_respons0.41017274
104MP0005381_digestive/alimentary_phenotyp0.40834833
105MP0008260_abnormal_autophagy0.40714595
106MP0008874_decreased_physiological_sensi0.40541507
107MP0005666_abnormal_adipose_tissue0.40518354
108MP0004782_abnormal_surfactant_physiolog0.40246955
109MP0003300_gastrointestinal_ulcer0.39783033
110MP0002135_abnormal_kidney_morphology0.39772444
111MP0002168_other_aberrant_phenotype0.38925550
112MP0006082_CNS_inflammation0.38679567
113MP0002796_impaired_skin_barrier0.37239157
114MP0003718_maternal_effect0.36688448
115MP0001881_abnormal_mammary_gland0.36075096
116MP0008872_abnormal_physiological_respon0.36064827
117MP0002098_abnormal_vibrissa_morphology0.34998488
118MP0002822_catalepsy0.34178151
119MP0001853_heart_inflammation0.33081222
120MP0001873_stomach_inflammation0.31713798
121MP0003315_abnormal_perineum_morphology0.30870160
122MP0009115_abnormal_fat_cell0.29894125
123MP0002069_abnormal_eating/drinking_beha0.29274505
124MP0000249_abnormal_blood_vessel0.29165169
125MP0009672_abnormal_birth_weight0.28747962
126MP0002837_dystrophic_cardiac_calcinosis0.28577910
127MP0002970_abnormal_white_adipose0.28157844
128MP0005167_abnormal_blood-brain_barrier0.27609842
129MP0003959_abnormal_lean_body0.25698698
130MP0002132_abnormal_respiratory_system0.25611261

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.93912066
2Intrahepatic cholestasis (HP:0001406)6.42592248
3Deep venous thrombosis (HP:0002625)6.20871919
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.96898840
5Xanthomatosis (HP:0000991)5.66817759
6Hypobetalipoproteinemia (HP:0003563)5.57297489
7Prolonged partial thromboplastin time (HP:0003645)5.41604108
8Abnormality of glutamine family amino acid metabolism (HP:0010902)4.75992324
9Hyperlipoproteinemia (HP:0010980)4.73606089
10Hyperglycinuria (HP:0003108)4.63285313
11Hyperammonemia (HP:0001987)4.59064767
12Ketosis (HP:0001946)4.51840830
13Hyperglycinemia (HP:0002154)4.49611163
14Complement deficiency (HP:0004431)4.40456000
15Abnormality of glycine metabolism (HP:0010895)4.37615694
16Abnormality of serine family amino acid metabolism (HP:0010894)4.37615694
17Abnormality of aspartate family amino acid metabolism (HP:0010899)4.23968634
18Joint hemorrhage (HP:0005261)4.21417423
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.13227032
20Hypolipoproteinemia (HP:0010981)4.04815746
21Abnormality of fatty-acid metabolism (HP:0004359)3.81676145
22Hypoglycemic coma (HP:0001325)3.79051676
23Gout (HP:0001997)3.77756408
24Fat malabsorption (HP:0002630)3.77299321
25Abnormality of the common coagulation pathway (HP:0010990)3.75316078
26Abnormality of methionine metabolism (HP:0010901)3.68913530
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.68259684
28Epidermoid cyst (HP:0200040)3.67666318
29Ketoacidosis (HP:0001993)3.59417399
30Widely patent fontanelles and sutures (HP:0004492)3.55663137
31Abnormality of pyrimidine metabolism (HP:0004353)3.51964504
32Abnormality of nucleobase metabolism (HP:0010932)3.50059858
33Abnormality of purine metabolism (HP:0004352)3.49107535
34Hypoalphalipoproteinemia (HP:0003233)3.42004438
35Conjugated hyperbilirubinemia (HP:0002908)3.35356418
36Delayed CNS myelination (HP:0002188)3.33679522
37Abnormality of vitamin metabolism (HP:0100508)3.33111283
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.32273235
39Confusion (HP:0001289)3.29610899
40Hemorrhage of the eye (HP:0011885)3.28567848
41Abnormality of the intrinsic pathway (HP:0010989)3.23170065
42Abnormality of the vitamin B12 metabolism (HP:0004341)3.22846186
43Hyperbilirubinemia (HP:0002904)3.21418397
44Abnormality of complement system (HP:0005339)3.20776048
45Ileus (HP:0002595)3.11129625
46Hypercholesterolemia (HP:0003124)3.08031167
47Metabolic acidosis (HP:0001942)3.07886041
48Abnormality of serum amino acid levels (HP:0003112)3.03411898
49Dicarboxylic aciduria (HP:0003215)3.02786468
50Abnormality of dicarboxylic acid metabolism (HP:0010995)3.02786468
51Abnormality of vitamin B metabolism (HP:0004340)3.01668715
52Generalized aminoaciduria (HP:0002909)2.93569058
53Proximal tubulopathy (HP:0000114)2.87936101
54Nephritis (HP:0000123)2.85723321
55Megaloblastic anemia (HP:0001889)2.83779881
56Facial shape deformation (HP:0011334)2.83766598
57Potter facies (HP:0002009)2.83766598
58Lethargy (HP:0001254)2.83471869
59Hepatocellular carcinoma (HP:0001402)2.83375352
60Steatorrhea (HP:0002570)2.82555301
61Abnormal urine phosphate concentration (HP:0012599)2.82537044
62Alkalosis (HP:0001948)2.74944289
63Vascular calcification (HP:0004934)2.74889483
64Increased purine levels (HP:0004368)2.74758173
65Hyperuricemia (HP:0002149)2.74758173
66Malnutrition (HP:0004395)2.68552401
67Hypophosphatemia (HP:0002148)2.65281703
68Wide cranial sutures (HP:0010537)2.64589521
69Systemic lupus erythematosus (HP:0002725)2.58552907
70Pigmentary retinal degeneration (HP:0001146)2.57124910
71Chronic diarrhea (HP:0002028)2.53750661
72Glycosuria (HP:0003076)2.50023407
73Abnormality of urine glucose concentration (HP:0011016)2.50023407
74Spontaneous abortion (HP:0005268)2.49734397
75Cerebral edema (HP:0002181)2.49574821
76Vomiting (HP:0002013)2.45098538
77Irritability (HP:0000737)2.41141687
78Spastic diplegia (HP:0001264)2.41110311
79Cardiovascular calcification (HP:0011915)2.40949174
80Late onset (HP:0003584)2.40896115
81Neonatal onset (HP:0003623)2.38943271
82Myocardial infarction (HP:0001658)2.38152154
83Abnormality of proline metabolism (HP:0010907)2.34904714
84Hydroxyprolinuria (HP:0003080)2.34904714
85Enlarged kidneys (HP:0000105)2.31905195
86Hypochromic microcytic anemia (HP:0004840)2.31419217
87Hypoglycemic seizures (HP:0002173)2.29766882
88Pancreatitis (HP:0001733)2.22651403
89Abnormal gallbladder physiology (HP:0012438)2.22596266
90Cholecystitis (HP:0001082)2.22596266
91Acanthocytosis (HP:0001927)2.22058313
92Sensorimotor neuropathy (HP:0007141)2.20840914
93Purpura (HP:0000979)2.18342027
94Rickets (HP:0002748)2.17256076
95Skin nodule (HP:0200036)2.17101122
96Abnormality of alkaline phosphatase activity (HP:0004379)2.13438656
97Glomerulonephritis (HP:0000099)2.12286395
98Abnormal gallbladder morphology (HP:0012437)2.11695880
99Cerebral palsy (HP:0100021)2.11078844
100Abdominal distention (HP:0003270)2.09796891
101Cholelithiasis (HP:0001081)2.08921117
102Thin bony cortex (HP:0002753)2.08673864
103Mitral stenosis (HP:0001718)2.07645458
104Menorrhagia (HP:0000132)2.06063395
105Brushfield spots (HP:0001088)2.04051586
106Osteomalacia (HP:0002749)2.03419737
107Poikilocytosis (HP:0004447)2.03227487
108Opisthotonus (HP:0002179)2.03173492
109Abnormal enzyme/coenzyme activity (HP:0012379)2.03149855
110Hypotension (HP:0002615)2.02014658
111Elevated alkaline phosphatase (HP:0003155)2.01441781
112Focal segmental glomerulosclerosis (HP:0000097)2.00745382
113Recurrent gram-negative bacterial infections (HP:0005420)1.99693326
114Esophageal varix (HP:0002040)1.97977488
115Nausea (HP:0002018)1.95472065
116Amyloidosis (HP:0011034)1.94510127
117Nephrolithiasis (HP:0000787)1.93402257
118Gingival bleeding (HP:0000225)1.92295372
119Abnormal cartilage morphology (HP:0002763)1.90424585
120Hyperphosphaturia (HP:0003109)1.90393075
121Thrombophlebitis (HP:0004418)1.89597416
122Hypokalemic alkalosis (HP:0001949)1.86484660
123Renal cortical cysts (HP:0000803)1.83463747
124Hyperinsulinemic hypoglycemia (HP:0000825)1.81479156
125Abnormality of transition element cation homeostasis (HP:0011030)1.81333628
126Hypophosphatemic rickets (HP:0004912)1.80911303
127Delayed epiphyseal ossification (HP:0002663)1.80420841
128Renal tubular dysfunction (HP:0000124)1.78678727
129Glomerulosclerosis (HP:0000096)1.71196431

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.29152996
2ACVR1B5.82047554
3ERN14.48254600
4FGFR44.04502509
5SIK13.75783899
6TAOK32.76093589
7WNK32.64151218
8WNK42.49654270
9EPHA22.46683806
10TESK22.45062019
11INSRR2.39838346
12MST1R2.36332054
13PKN22.29627548
14OXSR12.09864975
15ERBB42.00893010
16FLT31.98181253
17EPHA41.92582160
18SMG11.74896091
19MAP2K41.72497456
20TRIB31.72240843
21MAPK111.72212742
22TYK21.67089105
23PIK3CG1.61064016
24PRPF4B1.60496503
25MAP3K21.60035263
26GRK61.42019236
27NEK91.40828869
28ABL21.39254881
29MAP2K31.36233987
30PTK61.31691364
31PINK11.29973783
32FRK1.29261724
33STK38L1.27316625
34KDR1.25004021
35TBK11.23494241
36MAP3K71.20480779
37ICK1.19264789
38MAP3K31.15340107
39JAK21.11197414
40TESK11.09995729
41TIE11.08496164
42PRKAA21.04803800
43MAP3K121.03495853
44TGFBR21.02941145
45MAP3K111.01959649
46RIPK40.99177771
47MAPK150.98019511
48DDR20.96591797
49MAP2K60.96132349
50DAPK20.95393057
51MAP3K140.94202265
52MATK0.93607277
53EPHB10.93105586
54PIK3CA0.92103174
55NEK10.89779223
56MAPK40.89525863
57LATS10.89368742
58IRAK30.89125132
59TNIK0.85683557
60DYRK1B0.79960652
61JAK10.78654346
62KSR20.76618284
63DAPK10.74649378
64PRKCZ0.73611634
65GSK3A0.72660133
66RIPK10.71484026
67MAP4K10.69572811
68SGK4940.69337175
69SGK2230.69337175
70IKBKE0.68816158
71PIM20.68368417
72MAP3K100.67530319
73CSK0.67333105
74PDK30.67086713
75PDK40.67086713
76PRKACG0.66960221
77SGK30.66378987
78ERBB20.64276452
79MAPK120.63240639
80NME10.63112015
81TAOK10.62861935
82NME20.62151206
83MET0.61771252
84PRKAA10.61652699
85RET0.61545569
86CDK60.60889808
87CSF1R0.60008200
88EPHB20.59296671
89STK160.58754737
90PDPK10.58192317
91CDC42BPA0.56821094
92PTK20.55742534
93SGK20.55675742
94KIT0.53090420
95EEF2K0.51665080
96FGFR20.50899742
97AKT30.49373019
98LRRK20.49173148
99CAMK1D0.48932585
100CAMK2G0.47897565
101MAP2K20.47860392
102SRC0.47027491
103STK390.46053036
104SCYL20.45657815
105PAK40.43518915
106PDK10.42858831
107EPHA30.42378755
108CAMK2B0.42169353
109PDK20.40970485
110MAP3K80.40730694
111BTK0.40074146
112CAMK2D0.39598692
113TAOK20.38027595
114MAP3K50.37505505
115PRKCQ0.37087326
116PDGFRA0.36661497
117MAP3K60.36309652
118ZAP700.35452531
119MYLK0.35415382
120GRK10.35111859
121STK240.33783010
122FER0.33760583
123IGF1R0.33377234
124BLK0.33296201
125PRKACA0.32778870
126CDK70.32726922
127ARAF0.31659020
128PRKG20.30273305
129LMTK20.29368111
130CAMK40.29217712
131CDK40.28486999
132PIM10.28383709
133CSNK1G10.28233764
134CSNK2A10.27961762
135PRKCI0.26652025
136FYN0.26065196
137MAP3K10.25467123
138FGFR30.25289958
139PRKCA0.24946206
140MAP2K10.24927309
141IRAK10.24725531
142NLK0.24511950
143CSNK1A10.23886237
144PRKCD0.23712339
145CSNK2A20.23458605
146MST40.23161925

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.09844013
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.51174102
3Nitrogen metabolism_Homo sapiens_hsa009103.05769192
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.03969856
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.80709693
6Arginine biosynthesis_Homo sapiens_hsa002202.79732368
7Tryptophan metabolism_Homo sapiens_hsa003802.69372169
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.62855004
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.62472117
10Fatty acid degradation_Homo sapiens_hsa000712.55613325
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.50672216
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.47566624
13Butanoate metabolism_Homo sapiens_hsa006502.38672487
14Complement and coagulation cascades_Homo sapiens_hsa046102.33283393
15Peroxisome_Homo sapiens_hsa041462.23124370
16Propanoate metabolism_Homo sapiens_hsa006402.16194648
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09074869
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94535331
19Chemical carcinogenesis_Homo sapiens_hsa052041.87816057
20Histidine metabolism_Homo sapiens_hsa003401.85921146
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.85445959
22Fatty acid metabolism_Homo sapiens_hsa012121.84527866
23PPAR signaling pathway_Homo sapiens_hsa033201.82810494
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.81849735
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.79284902
26beta-Alanine metabolism_Homo sapiens_hsa004101.78554031
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.74492908
28Selenocompound metabolism_Homo sapiens_hsa004501.64886048
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61686707
30Retinol metabolism_Homo sapiens_hsa008301.60208861
31Pyruvate metabolism_Homo sapiens_hsa006201.58348181
32Sulfur metabolism_Homo sapiens_hsa009201.57893030
33Bile secretion_Homo sapiens_hsa049761.55793383
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.55363154
35Caffeine metabolism_Homo sapiens_hsa002321.52972829
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.52161751
37Staphylococcus aureus infection_Homo sapiens_hsa051501.47596684
38Phenylalanine metabolism_Homo sapiens_hsa003601.44347404
39Starch and sucrose metabolism_Homo sapiens_hsa005001.39514629
40Folate biosynthesis_Homo sapiens_hsa007901.38616497
41Fatty acid elongation_Homo sapiens_hsa000621.34338821
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32647448
43Tyrosine metabolism_Homo sapiens_hsa003501.28486961
44Carbon metabolism_Homo sapiens_hsa012001.28481196
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.26373243
46Biosynthesis of amino acids_Homo sapiens_hsa012301.22280057
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21396867
48Vitamin digestion and absorption_Homo sapiens_hsa049771.17122606
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15878355
50Fat digestion and absorption_Homo sapiens_hsa049751.14098264
51ABC transporters_Homo sapiens_hsa020101.09543105
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.08626219
53Arginine and proline metabolism_Homo sapiens_hsa003301.05798550
54Steroid biosynthesis_Homo sapiens_hsa001001.00510625
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98734437
56Sulfur relay system_Homo sapiens_hsa041220.97784168
57Glutathione metabolism_Homo sapiens_hsa004800.92294441
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89570903
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86814129
60Lysine degradation_Homo sapiens_hsa003100.86514617
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83692147
62Glycerolipid metabolism_Homo sapiens_hsa005610.76156136
63Pentose phosphate pathway_Homo sapiens_hsa000300.70422243
64Vitamin B6 metabolism_Homo sapiens_hsa007500.68307246
65One carbon pool by folate_Homo sapiens_hsa006700.67612244
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53048232
67* Metabolic pathways_Homo sapiens_hsa011000.52872972
68Galactose metabolism_Homo sapiens_hsa000520.39744495
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34803829
70Fatty acid biosynthesis_Homo sapiens_hsa000610.32911802
71Ether lipid metabolism_Homo sapiens_hsa005650.25379701
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24840639
73Sphingolipid metabolism_Homo sapiens_hsa006000.24256091
74* Fructose and mannose metabolism_Homo sapiens_hsa000510.22983332
75Pertussis_Homo sapiens_hsa051330.19154423
76Insulin resistance_Homo sapiens_hsa049310.18743191
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.17781947
78Prion diseases_Homo sapiens_hsa050200.16589412
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14669730
80Linoleic acid metabolism_Homo sapiens_hsa005910.14497167
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10948661
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.10354783
83Asthma_Homo sapiens_hsa053100.06043618
84Renin-angiotensin system_Homo sapiens_hsa046140.05057871
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.03002172
86Glucagon signaling pathway_Homo sapiens_hsa049220.02243422
87African trypanosomiasis_Homo sapiens_hsa05143-0.2198695
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2007339
89Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1944284
90Parkinsons disease_Homo sapiens_hsa05012-0.1935289
91Insulin signaling pathway_Homo sapiens_hsa04910-0.1591982
92Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1460033
93Hepatitis C_Homo sapiens_hsa05160-0.1456346
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.1415899
95Lysosome_Homo sapiens_hsa04142-0.1411085
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1401157
97Autoimmune thyroid disease_Homo sapiens_hsa05320-0.1350489
98Oxidative phosphorylation_Homo sapiens_hsa00190-0.1255344
99Regulation of autophagy_Homo sapiens_hsa04140-0.1244602
100Serotonergic synapse_Homo sapiens_hsa04726-0.1159400
101Allograft rejection_Homo sapiens_hsa05330-0.1108895
102Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1103891
103Cocaine addiction_Homo sapiens_hsa05030-0.0792266
104Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0738460
105Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0699029
106N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0679028
107Protein digestion and absorption_Homo sapiens_hsa04974-0.0662307
108Mineral absorption_Homo sapiens_hsa04978-0.0606735
109Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0376403
110Other glycan degradation_Homo sapiens_hsa00511-0.0352153
111Pancreatic secretion_Homo sapiens_hsa04972-0.0344451
112AMPK signaling pathway_Homo sapiens_hsa04152-0.0262963
113Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0231390
114Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0153802

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