KHNYN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing a ribonuclease NYN domain. The function of this protein has yet to be determined. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.21635733
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.21635733
3antigen processing and presentation of endogenous antigen (GO:0019883)4.95694185
4positive regulation of gamma-delta T cell activation (GO:0046645)4.87814325
5regulation of gamma-delta T cell differentiation (GO:0045586)4.59481508
6regulation of gamma-delta T cell activation (GO:0046643)4.13758966
7regulation of cholesterol homeostasis (GO:2000188)3.90264438
8positive thymic T cell selection (GO:0045059)3.56011692
9alpha-linolenic acid metabolic process (GO:0036109)3.53648015
10mannose metabolic process (GO:0006013)3.48824623
11urea metabolic process (GO:0019627)3.42849691
12urea cycle (GO:0000050)3.42849691
13negative regulation of cholesterol transport (GO:0032375)3.40381753
14negative regulation of sterol transport (GO:0032372)3.40381753
15positive regulation of histone deacetylation (GO:0031065)3.36709356
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.34406286
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.30033047
18negative thymic T cell selection (GO:0045060)3.27073629
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.26289722
20embryonic process involved in female pregnancy (GO:0060136)3.23531050
21phospholipid homeostasis (GO:0055091)3.22803932
22response to muramyl dipeptide (GO:0032495)3.21649128
23positive regulation of B cell differentiation (GO:0045579)3.19583405
24phospholipid efflux (GO:0033700)3.19224932
25plasma lipoprotein particle assembly (GO:0034377)3.18801111
26kynurenine metabolic process (GO:0070189)3.16665422
27negative T cell selection (GO:0043383)3.16622450
28protein-lipid complex assembly (GO:0065005)3.11886582
29JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.11630181
30negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.10464389
31negative regulation of cell killing (GO:0031342)3.10464389
32regulation of interleukin-12 biosynthetic process (GO:0045075)3.10136037
33detection of other organism (GO:0098543)3.09904420
34negative regulation of fibrinolysis (GO:0051918)3.09323379
35erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.06106041
36L-phenylalanine catabolic process (GO:0006559)3.06106041
37response to interleukin-15 (GO:0070672)3.05137265
38NIK/NF-kappaB signaling (GO:0038061)3.04793763
39modulation by symbiont of host defense response (GO:0052031)3.04455958
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.04455958
41modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.04455958
42positive regulation by organism of defense response of other organism involved in symbiotic interact3.04455958
43modulation by symbiont of host immune response (GO:0052553)3.04455958
44positive regulation by symbiont of host defense response (GO:0052509)3.04455958
45detection of bacterium (GO:0016045)3.02183381
46thymic T cell selection (GO:0045061)3.01639593
47nitrogen cycle metabolic process (GO:0071941)3.00354696
48response to peptidoglycan (GO:0032494)2.99971424
49pinocytosis (GO:0006907)2.99612450
50germinal center formation (GO:0002467)2.96804465
51protein carboxylation (GO:0018214)2.95923771
52peptidyl-glutamic acid carboxylation (GO:0017187)2.95923771
53valine metabolic process (GO:0006573)2.95322654
54L-phenylalanine metabolic process (GO:0006558)2.94883802
55erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.94883802
56aromatic amino acid family catabolic process (GO:0009074)2.93691840
57regulation of protein activation cascade (GO:2000257)2.91737634
58regulation of fatty acid beta-oxidation (GO:0031998)2.91659519
59complement activation, alternative pathway (GO:0006957)2.88233003
60indole-containing compound catabolic process (GO:0042436)2.87814599
61indolalkylamine catabolic process (GO:0046218)2.87814599
62tryptophan catabolic process (GO:0006569)2.87814599
63very-low-density lipoprotein particle assembly (GO:0034379)2.86857580
64dicarboxylic acid biosynthetic process (GO:0043650)2.84501834
65histone H3-K36 demethylation (GO:0070544)2.83693959
66antigen processing and presentation via MHC class Ib (GO:0002475)2.83031393
67high-density lipoprotein particle remodeling (GO:0034375)2.80464059
68regulation of fibrinolysis (GO:0051917)2.79405125
69regulation of B cell differentiation (GO:0045577)2.77464699
70growth hormone receptor signaling pathway (GO:0060396)2.76637302
71positive regulation of fatty acid beta-oxidation (GO:0032000)2.76263541
72regulation of complement activation (GO:0030449)2.75220246
73tryptophan metabolic process (GO:0006568)2.74673703
74cysteine metabolic process (GO:0006534)2.73551290
75lysine catabolic process (GO:0006554)2.72370719
76lysine metabolic process (GO:0006553)2.72370719
77positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.72249905
78positive regulation of extracellular matrix organization (GO:1903055)2.71035078
79detection of external biotic stimulus (GO:0098581)2.67265823
80sulfur amino acid catabolic process (GO:0000098)2.66425277
81macrophage activation involved in immune response (GO:0002281)2.65943868
82homocysteine metabolic process (GO:0050667)2.65282890
83T cell selection (GO:0045058)2.65112948
84positive regulation of Cdc42 GTPase activity (GO:0043089)2.65045155
85regulation of necroptotic process (GO:0060544)2.61941599
86bile acid biosynthetic process (GO:0006699)2.61586888
87B cell receptor signaling pathway (GO:0050853)2.60037059
88protein localization to endosome (GO:0036010)2.59607184
89negative regulation of erythrocyte differentiation (GO:0045647)2.59596852
90cellular extravasation (GO:0045123)2.59252594
912-oxoglutarate metabolic process (GO:0006103)2.58944051
92regulation of triglyceride catabolic process (GO:0010896)2.58794991
93negative regulation of lipid transport (GO:0032369)2.58403468
94reverse cholesterol transport (GO:0043691)2.56834628
95negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.55970773
96positive T cell selection (GO:0043368)2.55858986
97regulation of extracellular matrix disassembly (GO:0010715)2.55669019
98glyoxylate metabolic process (GO:0046487)2.55450819
99negative regulation of fatty acid transport (GO:2000192)2.54470307
100intestinal cholesterol absorption (GO:0030299)2.53534138
101regulation of cholesterol storage (GO:0010885)2.52709078
102plasma lipoprotein particle clearance (GO:0034381)2.52639865
103detection of molecule of bacterial origin (GO:0032490)2.51311880
104regulation of B cell receptor signaling pathway (GO:0050855)2.51184218
105positive regulation of natural killer cell differentiation (GO:0032825)2.50675714
106regulation of interferon-beta biosynthetic process (GO:0045357)2.49006889
107positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.48265984
108positive regulation of lipid catabolic process (GO:0050996)2.47404909
109response to type I interferon (GO:0034340)2.47274652
110natural killer cell differentiation (GO:0001779)2.47015435
111glycine metabolic process (GO:0006544)2.46960474
112serine family amino acid catabolic process (GO:0009071)2.46101122
113myeloid dendritic cell differentiation (GO:0043011)2.46070634
114tolerance induction (GO:0002507)2.45240506
115complement activation, classical pathway (GO:0006958)2.45143997
116type I interferon signaling pathway (GO:0060337)2.44948742
117cellular response to type I interferon (GO:0071357)2.44948742
118regulation of type I interferon-mediated signaling pathway (GO:0060338)2.44548646
119ethanol oxidation (GO:0006069)2.42510142
120hypotonic response (GO:0006971)2.41816760
121regulation of T-helper 2 cell differentiation (GO:0045628)2.41589613
122cellular response to virus (GO:0098586)2.40956700
123cholesterol efflux (GO:0033344)2.40576541
124detection of biotic stimulus (GO:0009595)2.39268091
125negative regulation of toll-like receptor signaling pathway (GO:0034122)2.38512183
126positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.37696390
127bile acid metabolic process (GO:0008206)2.37391510
128regulation of response to interferon-gamma (GO:0060330)2.35044454
129negative regulation of interleukin-12 production (GO:0032695)2.34961551
130leukocyte aggregation (GO:0070486)2.34800911
131regulation of extracellular matrix organization (GO:1903053)2.34569035
132response to laminar fluid shear stress (GO:0034616)2.34372005
133modulation by symbiont of host cellular process (GO:0044068)2.34025221
134regulation of humoral immune response (GO:0002920)2.33861655
135lipopolysaccharide-mediated signaling pathway (GO:0031663)2.33851581
136positive regulation of cellular amide metabolic process (GO:0034250)2.33197937
137regulation of apoptotic cell clearance (GO:2000425)2.33171156
138regulation of cholesterol transport (GO:0032374)2.32752317
139regulation of sterol transport (GO:0032371)2.32752317
140regulation of histone H3-K27 methylation (GO:0061085)2.32658764
141regulation of superoxide anion generation (GO:0032928)2.32619825
142low-density lipoprotein particle clearance (GO:0034383)2.31420503
143cellular response to growth hormone stimulus (GO:0071378)2.31177343
144regulation of leukocyte degranulation (GO:0043300)2.30845778
145positive regulation of protein deacetylation (GO:0090312)2.30200544
146macromolecular complex remodeling (GO:0034367)2.29435835
147neutrophil activation involved in immune response (GO:0002283)2.27463800
148negative regulation of lymphocyte mediated immunity (GO:0002707)2.24695602
149regulation of T cell tolerance induction (GO:0002664)2.24027373
150positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.23445227
151regulation of dendritic cell antigen processing and presentation (GO:0002604)2.21310691
1523-UTR-mediated mRNA stabilization (GO:0070935)2.20175581
153regulation of necrotic cell death (GO:0010939)2.19463443
154regulation of myeloid leukocyte mediated immunity (GO:0002886)2.18793783
155positive regulation of interferon-alpha production (GO:0032727)2.18351193
156negative regulation of cytokine production involved in immune response (GO:0002719)2.17632208
157response to host (GO:0075136)2.16380196
158response to host defenses (GO:0052200)2.16380196
159response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.16380196
160regulation of tolerance induction (GO:0002643)2.16247189
161negative regulation of type 2 immune response (GO:0002829)2.16091602
162immunoglobulin mediated immune response (GO:0016064)2.14097076
163myeloid dendritic cell activation (GO:0001773)2.13567315
164T cell migration (GO:0072678)2.12379120
165negative regulation of leukocyte mediated immunity (GO:0002704)2.12070154
166epithelial cell differentiation involved in prostate gland development (GO:0060742)2.10873807
167negative regulation of necroptotic process (GO:0060546)2.10663576
168positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.09958857

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.67070214
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.50843020
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.41245076
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.40330145
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.35701395
6MYC_22102868_ChIP-Seq_BL_Human3.15834569
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.06469048
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.01632570
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.91970258
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.75966124
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.39137977
12VDR_21846776_ChIP-Seq_THP-1_Human2.38890409
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.25263767
14TCF7_22412390_ChIP-Seq_EML_Mouse2.21543837
15GATA1_22025678_ChIP-Seq_K562_Human2.19121533
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.17985333
17MAF_26560356_Chip-Seq_TH1_Human2.13463999
18EGR1_23403033_ChIP-Seq_LIVER_Mouse2.10148303
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.07377997
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.98008009
21KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.96832060
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.90941909
23RUNX_20019798_ChIP-Seq_JUKART_Human1.90665180
24KDM2B_26808549_Chip-Seq_DND41_Human1.90079163
25UTX_26944678_Chip-Seq_JUKART_Human1.89058952
26* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85042429
27KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.84824309
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.84327065
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.84142008
30NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.83637475
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.83255173
32MYB_26560356_Chip-Seq_TH1_Human1.82612496
33* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82048725
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.81280532
35CLOCK_20551151_ChIP-Seq_293T_Human1.79863535
36E2F7_22180533_ChIP-Seq_HELA_Human1.79609099
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.78840676
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76825872
39SCL_19346495_ChIP-Seq_HPC-7_Human1.76184411
40MYB_26560356_Chip-Seq_TH2_Human1.74989242
41* ELK3_25401928_ChIP-Seq_HUVEC_Human1.73798349
42* IRF8_27001747_Chip-Seq_BMDM_Mouse1.70220001
43MYB_21317192_ChIP-Seq_ERMYB_Mouse1.69702129
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.69647915
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.66149306
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61311976
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.59527003
48BP1_19119308_ChIP-ChIP_Hs578T_Human1.59354260
49IRF8_21731497_ChIP-ChIP_J774_Mouse1.55645231
50VDR_24763502_ChIP-Seq_THP-1_Human1.55237064
51* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.48703681
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46468807
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45448641
54STAT4_19710469_ChIP-ChIP_TH1__Mouse1.44337637
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43810425
56FOXM1_23109430_ChIP-Seq_U2OS_Human1.42123741
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.41088226
58TP63_17297297_ChIP-ChIP_HaCaT_Human1.40928173
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39122606
60* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37778777
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36344410
62MAF_26560356_Chip-Seq_TH2_Human1.34093916
63ZNF263_19887448_ChIP-Seq_K562_Human1.32444686
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32241918
65GATA1_19941826_ChIP-Seq_K562_Human1.31974390
66KDM2B_26808549_Chip-Seq_K562_Human1.31943990
67NCOR1_26117541_ChIP-Seq_K562_Human1.26653612
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23596190
69SPI1_23127762_ChIP-Seq_K562_Human1.22218899
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21584822
71LXR_22292898_ChIP-Seq_THP-1_Human1.21185486
72FOXO3_23340844_ChIP-Seq_DLD1_Human1.20933079
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.19274325
74* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18984112
75GATA1_19941827_ChIP-Seq_MEL_Mouse1.18792874
76KDM2B_26808549_Chip-Seq_JURKAT_Human1.18769291
77GATA6_25053715_ChIP-Seq_YYC3_Human1.15259348
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13544059
79* RACK7_27058665_Chip-Seq_MCF-7_Human1.13412341
80GATA3_27048872_Chip-Seq_THYMUS_Human1.12637930
81* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10918410
82ESR1_21235772_ChIP-Seq_MCF-7_Human1.08411143
83* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08252488
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07410716
85SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06876322
86* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06610757
87SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05368395
88EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05252715
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05086803
90HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04542524
91CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04252810
92TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.03704446
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03674304
94CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02316272
95GATA2_19941826_ChIP-Seq_K562_Human1.02221971
96FOXA2_19822575_ChIP-Seq_HepG2_Human1.01653756
97* SPI1_23547873_ChIP-Seq_NB4_Human1.00448702
98VDR_24787735_ChIP-Seq_THP-1_Human0.99763358
99* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99057006
100ESR2_21235772_ChIP-Seq_MCF-7_Human0.98938411
101P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97966317
102SMAD_19615063_ChIP-ChIP_OVARY_Human0.97927632
103STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97227540
104FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97191885
105P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97100384
106SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96797826
107ATF3_27146783_Chip-Seq_COLON_Human0.96057778
108PU_27001747_Chip-Seq_BMDM_Mouse0.94597838
109SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93540790
110RARG_19884340_ChIP-ChIP_MEFs_Mouse0.93402708
111PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92595552
112CIITA_25753668_ChIP-Seq_RAJI_Human0.91751978
113* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90979160
114TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86513860
115Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.86461579
116RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.84487645
117RUNX1_27514584_Chip-Seq_MCF-7_Human0.83884282
118CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83302253

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.97107994
2MP0002139_abnormal_hepatobiliary_system3.78328062
3MP0005365_abnormal_bile_salt2.95489542
4MP0005085_abnormal_gallbladder_physiolo2.77682470
5MP0005451_abnormal_body_composition2.65727058
6MP0003705_abnormal_hypodermis_morpholog2.63714770
7MP0003300_gastrointestinal_ulcer2.55824714
8MP0009840_abnormal_foam_cell2.53985425
9MP0003252_abnormal_bile_duct2.43837082
10MP0000685_abnormal_immune_system2.36330836
11MP0001835_abnormal_antigen_presentation2.27415806
12MP0001800_abnormal_humoral_immune2.18001883
13MP0003724_increased_susceptibility_to2.08602829
14MP0003191_abnormal_cellular_cholesterol2.06337208
15MP0010329_abnormal_lipoprotein_level2.03852595
16MP0001873_stomach_inflammation2.00465025
17MP0005387_immune_system_phenotype1.98894016
18MP0001790_abnormal_immune_system1.98894016
19MP0003303_peritoneal_inflammation1.96035001
20MP0010234_abnormal_vibrissa_follicle1.95448445
21MP0002166_altered_tumor_susceptibility1.94013725
22MP0002138_abnormal_hepatobiliary_system1.93833377
23MP0002254_reproductive_system_inflammat1.93277516
24MP0010352_gastrointestinal_tract_polyps1.93122528
25MP0005083_abnormal_biliary_tract1.92541281
26MP0008260_abnormal_autophagy1.92436397
27MP0008875_abnormal_xenobiotic_pharmacok1.87205345
28MP0000609_abnormal_liver_physiology1.77648356
29MP0003436_decreased_susceptibility_to1.75876713
30MP0003763_abnormal_thymus_physiology1.73147118
31MP0004947_skin_inflammation1.71425245
32MP0005409_darkened_coat_color1.69268865
33MP0001666_abnormal_nutrient_absorption1.68076909
34MP0002452_abnormal_antigen_presenting1.66685321
35MP0005076_abnormal_cell_differentiation1.61149571
36MP0010155_abnormal_intestine_physiology1.58347357
37MP0005464_abnormal_platelet_physiology1.58173261
38MP0005671_abnormal_response_to1.56945525
39MP0002723_abnormal_immune_serum1.56317694
40MP0002398_abnormal_bone_marrow1.52896533
41MP0002420_abnormal_adaptive_immunity1.48019063
42MP0001819_abnormal_immune_cell1.46502904
43MP0003806_abnormal_nucleotide_metabolis1.45588751
44MP0002998_abnormal_bone_remodeling1.44120239
45MP0002396_abnormal_hematopoietic_system1.39885733
46MP0005000_abnormal_immune_tolerance1.39593913
47MP0003866_abnormal_defecation1.39050497
48MP0009278_abnormal_bone_marrow1.38359643
49MP0003566_abnormal_cell_adhesion1.37749260
50MP0000716_abnormal_immune_system1.35614774
51MP0002009_preneoplasia1.35457147
52MP0005025_abnormal_response_to1.34969213
53MP0000689_abnormal_spleen_morphology1.33993366
54MP0003183_abnormal_peptide_metabolism1.29585168
55MP0004510_myositis1.29407002
56MP0002722_abnormal_immune_system1.28656152
57MP0004808_abnormal_hematopoietic_stem1.28385297
58MP0003828_pulmonary_edema1.25956271
59MP0002006_tumorigenesis1.25259002
60MP0002419_abnormal_innate_immunity1.22390816
61MP0009785_altered_susceptibility_to1.21915751
62MP0001845_abnormal_inflammatory_respons1.21443884
63MP0004381_abnormal_hair_follicle1.21121476
64MP0008438_abnormal_cutaneous_collagen1.20548381
65MP0002429_abnormal_blood_cell1.18279615
66MP0004264_abnormal_extraembryonic_tissu1.18272228
67MP0002148_abnormal_hypersensitivity_rea1.18038135
68MP0001851_eye_inflammation1.15907244
69MP0002405_respiratory_system_inflammati1.15165898
70MP0003453_abnormal_keratinocyte_physiol1.14403706
71MP0001853_heart_inflammation1.12991435
72MP0008469_abnormal_protein_level1.12714793
73MP0005023_abnormal_wound_healing1.12175017
74MP0000598_abnormal_liver_morphology1.12096429
75MP0001849_ear_inflammation1.10570566
76MP0008961_abnormal_basal_metabolism1.07408623
77MP0001545_abnormal_hematopoietic_system1.05671993
78MP0005397_hematopoietic_system_phenotyp1.05671993
79MP0000703_abnormal_thymus_morphology1.05484775
80MP0005319_abnormal_enzyme/_coenzyme1.04377623
81MP0002118_abnormal_lipid_homeostasis1.02842536
82MP0002132_abnormal_respiratory_system0.99448294
83MP0000569_abnormal_digit_pigmentation0.98524269
84MP0006082_CNS_inflammation0.98433211
85MP0005666_abnormal_adipose_tissue0.97341308
86MP0000465_gastrointestinal_hemorrhage0.96227077
87MP0003656_abnormal_erythrocyte_physiolo0.95036643
88MP0001958_emphysema0.93813532
89MP0005164_abnormal_response_to0.92555424
90MP0009763_increased_sensitivity_to0.92274546
91MP0010307_abnormal_tumor_latency0.91864077
92MP0005332_abnormal_amino_acid0.91680885
93MP0009333_abnormal_splenocyte_physiolog0.90835425
94MP0002796_impaired_skin_barrier0.90426109
95MP0002089_abnormal_postnatal_growth/wei0.86987772
96MP0003868_abnormal_feces_composition0.86450670
97MP0005058_abnormal_lysosome_morphology0.86426015
98MP0009643_abnormal_urine_homeostasis0.86263616
99MP0005375_adipose_tissue_phenotype0.85338455
100MP0003091_abnormal_cell_migration0.84864441
101MP0002877_abnormal_melanocyte_morpholog0.83844150
102MP0004883_abnormal_blood_vessel0.83571470
103MP0009115_abnormal_fat_cell0.83276227
104MP0000604_amyloidosis0.83236111
105MP0003045_fibrosis0.83145846
106MP0000767_abnormal_smooth_muscle0.81529024
107MP0002136_abnormal_kidney_physiology0.80773303
108MP0003172_abnormal_lysosome_physiology0.80631956
109MP0001216_abnormal_epidermal_layer0.79880080
110MP0009764_decreased_sensitivity_to0.79629759
111MP0000249_abnormal_blood_vessel0.79407784
112MP0002060_abnormal_skin_morphology0.79284688
113MP0003329_amyloid_beta_deposits0.78877358
114MP0000477_abnormal_intestine_morphology0.73011764
115MP0005584_abnormal_enzyme/coenzyme_acti0.72385462
116MP0001533_abnormal_skeleton_physiology0.70607213
117MP0001915_intracranial_hemorrhage0.70513182
118MP0000858_altered_metastatic_potential0.70243499
119MP0002933_joint_inflammation0.69999642
120MP0006054_spinal_hemorrhage0.69316764
121MP0004185_abnormal_adipocyte_glucose0.69117777
122MP0002928_abnormal_bile_duct0.69063316
123MP0002086_abnormal_extraembryonic_tissu0.68441549
124MP0000490_abnormal_crypts_of0.67546446
125MP0004130_abnormal_muscle_cell0.66278667
126MP0002019_abnormal_tumor_incidence0.64998680
127MP0005310_abnormal_salivary_gland0.60818417

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.11074105
2Intrahepatic cholestasis (HP:0001406)3.43632416
3Xanthomatosis (HP:0000991)3.41143406
4Abnormality of monocarboxylic acid metabolism (HP:0010996)3.33214128
5Myocardial infarction (HP:0001658)3.22744622
6Colitis (HP:0002583)3.19383245
7Abnormality of the fingertips (HP:0001211)3.08345913
8Recurrent viral infections (HP:0004429)2.99568229
9Gastrointestinal inflammation (HP:0004386)2.94607133
10Hypobetalipoproteinemia (HP:0003563)2.94491094
11Abnormality of macrophages (HP:0004311)2.93329347
12Inflammation of the large intestine (HP:0002037)2.92338285
13Flat acetabular roof (HP:0003180)2.91948130
14Abnormality of the common coagulation pathway (HP:0010990)2.80741942
15Gingival bleeding (HP:0000225)2.78517392
16Complement deficiency (HP:0004431)2.76277701
17Abnormal delayed hypersensitivity skin test (HP:0002963)2.69622033
18Recurrent abscess formation (HP:0002722)2.68218758
19Myositis (HP:0100614)2.64315675
20Recurrent fungal infections (HP:0002841)2.63492544
21Mitral stenosis (HP:0001718)2.59192792
22Abnormality of aromatic amino acid family metabolism (HP:0004338)2.57846388
23Recurrent bronchitis (HP:0002837)2.55678304
24Orchitis (HP:0100796)2.55500584
25T lymphocytopenia (HP:0005403)2.54211050
26Pustule (HP:0200039)2.52565825
27Hyperlipoproteinemia (HP:0010980)2.51125288
28Hematochezia (HP:0002573)2.50530731
29Esophageal varix (HP:0002040)2.49976272
30Systemic lupus erythematosus (HP:0002725)2.49762620
31Abnormal platelet volume (HP:0011876)2.49468853
32Polycythemia (HP:0001901)2.48712649
33Thin bony cortex (HP:0002753)2.48225907
34Nasal polyposis (HP:0100582)2.46862253
35Chronic otitis media (HP:0000389)2.45323126
36Cerebral aneurysm (HP:0004944)2.42950882
37Abnormality of glutamine family amino acid metabolism (HP:0010902)2.42849068
38Spontaneous hematomas (HP:0007420)2.42801784
39Autoimmune thrombocytopenia (HP:0001973)2.41749586
40Acanthocytosis (HP:0001927)2.40998897
41Gingivitis (HP:0000230)2.40714826
42Abnormality of T cell number (HP:0011839)2.40354641
43Agammaglobulinemia (HP:0004432)2.40304890
44Increased mean platelet volume (HP:0011877)2.37232082
45Verrucae (HP:0200043)2.35665097
46Papilloma (HP:0012740)2.35665097
47Prolonged partial thromboplastin time (HP:0003645)2.31526141
48Hypolipoproteinemia (HP:0010981)2.28766074
49Abnormality of the nasal mucosa (HP:0000433)2.27937343
50IgM deficiency (HP:0002850)2.26593673
51Optic neuritis (HP:0100653)2.25734414
52Retrobulbar optic neuritis (HP:0100654)2.25734414
53Periodontitis (HP:0000704)2.23997495
54Joint hemorrhage (HP:0005261)2.23939834
55Protrusio acetabuli (HP:0003179)2.23203286
56Increased IgE level (HP:0003212)2.21359275
57Eczematoid dermatitis (HP:0000976)2.20237859
58Mediastinal lymphadenopathy (HP:0100721)2.17913120
59Epistaxis (HP:0000421)2.17597693
60Poikilocytosis (HP:0004447)2.16703009
61Cellulitis (HP:0100658)2.15704781
62Dysostosis multiplex (HP:0000943)2.15013657
63Abnormality of T cells (HP:0002843)2.14351961
64Glomerulonephritis (HP:0000099)2.13401273
65Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.13026549
66Panhypogammaglobulinemia (HP:0003139)2.12139587
67Abnormality of sulfur amino acid metabolism (HP:0004339)2.11518259
68Gastrointestinal stroma tumor (HP:0100723)2.11358788
69Arterial thrombosis (HP:0004420)2.09527573
70Epidermoid cyst (HP:0200040)2.09303598
71Aortic aneurysm (HP:0004942)2.08566345
72Subacute progressive viral hepatitis (HP:0006572)2.07998216
73Spastic diplegia (HP:0001264)2.07422356
74Impaired platelet aggregation (HP:0003540)2.05541722
75Abnormal platelet function (HP:0011869)2.05541722
76Hypoalphalipoproteinemia (HP:0003233)2.05463920
77Recurrent gram-negative bacterial infections (HP:0005420)2.05382774
78Asymmetry of the thorax (HP:0001555)2.04632966
79Reticulocytosis (HP:0001923)2.04421110
80Fatigue (HP:0012378)2.03861903
81Abnormality of complement system (HP:0005339)2.03506715
82Malnutrition (HP:0004395)2.03293859
83Peritonitis (HP:0002586)2.02493726
84Broad face (HP:0000283)2.01907654
85Segmental peripheral demyelination/remyelination (HP:0003481)2.01444008
86Emphysema (HP:0002097)2.00085540
87Meningitis (HP:0001287)1.99840903
88Arterial tortuosity (HP:0005116)1.99183907
89Hypercholesterolemia (HP:0003124)1.98975509
90Pseudobulbar signs (HP:0002200)1.98554716
91Recurrent cutaneous fungal infections (HP:0011370)1.98197475
92Chronic mucocutaneous candidiasis (HP:0002728)1.98197475
93Viral hepatitis (HP:0006562)1.97453554
94Abnormality of the peritoneum (HP:0002585)1.97371967
95Mucopolysacchariduria (HP:0008155)1.96644816
96Urinary glycosaminoglycan excretion (HP:0003541)1.96644816
97Prolonged bleeding time (HP:0003010)1.96509189
98Amyloidosis (HP:0011034)1.95965369
99Hyperacusis (HP:0010780)1.93415403
100Purpura (HP:0000979)1.93209822
101Aneurysm (HP:0002617)1.92576136
102Thrombocytosis (HP:0001894)1.92484816
103Hypoglycemic coma (HP:0001325)1.92460419
104Hepatitis (HP:0012115)1.92277985
105Gastrointestinal infarctions (HP:0005244)1.91862260
106Thrombophlebitis (HP:0004418)1.91589552
107Abnormality of the intrinsic pathway (HP:0010989)1.90159118
108Abnormality of T cell physiology (HP:0011840)1.88449305
109Hyperammonemia (HP:0001987)1.87734602
110Chronic diarrhea (HP:0002028)1.86855490
111Hypochromic anemia (HP:0001931)1.85510476
112Hepatocellular carcinoma (HP:0001402)1.85093384
113Mitral valve prolapse (HP:0001634)1.84864882
114Lymphopenia (HP:0001888)1.84771821
115Vasculitis (HP:0002633)1.84725684
116Elevated erythrocyte sedimentation rate (HP:0003565)1.83725845
117Fat malabsorption (HP:0002630)1.83504880
118Vertebral compression fractures (HP:0002953)1.82975166
119Interstitial pulmonary disease (HP:0006530)1.81839797
120Keratoconjunctivitis sicca (HP:0001097)1.81284747
121Abnormality of the lumbar spine (HP:0100712)1.80622816
122Pulmonary embolism (HP:0002204)1.80284084
123Menorrhagia (HP:0000132)1.79979931
124Polygenic inheritance (HP:0010982)1.78968989
125Abnormality of iron homeostasis (HP:0011031)1.78898703
126Joint swelling (HP:0001386)1.78566824
127Vascular tortuosity (HP:0004948)1.78399821
128Abnormality of polysaccharide metabolism (HP:0011012)1.78395873
129Abnormality of glycosaminoglycan metabolism (HP:0004371)1.78395873
130Abnormality of mucopolysaccharide metabolism (HP:0011020)1.78395873
131Pulmonary infiltrates (HP:0002113)1.78369133
132Abnormality of cells of the lymphoid lineage (HP:0012140)1.78260824
133Dilatation of the ascending aorta (HP:0005111)1.78060347
134Abnormality of carpal bone ossification (HP:0006257)1.77635566
135Recurrent skin infections (HP:0001581)1.77588532
136Recurrent bacterial skin infections (HP:0005406)1.77583200
137Syringomyelia (HP:0003396)1.77264097
138Spinal cord lesions (HP:0100561)1.77264097
139Macroorchidism (HP:0000053)1.77250033
140Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.77199053
141Cervical subluxation (HP:0003308)1.76110198
142Ulnar bowing (HP:0003031)1.76023655
143Hemorrhage of the eye (HP:0011885)1.74032467
144Dislocated radial head (HP:0003083)1.73687727
145Abnormality of transition element cation homeostasis (HP:0011030)1.73216143
146Abnormality of the thoracic spine (HP:0100711)1.73063896
147Abnormal ossification of hand bones (HP:0005921)1.71712267
148Coarse hair (HP:0002208)1.69304235
149Osteomyelitis (HP:0002754)1.66727616
150Obstructive lung disease (HP:0006536)1.63995326
151Chronic obstructive pulmonary disease (HP:0006510)1.63995326
152Cupped ribs (HP:0000887)1.61094177
153Abnormal tarsal ossification (HP:0008369)1.58637127
154Increased serum ferritin (HP:0003281)1.57723953
155Bone pain (HP:0002653)1.57413067

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.63121140
2MAP4K13.53657756
3EEF2K3.44802758
4MAP3K103.40946612
5TRIB33.22725947
6PKN23.16624225
7FGFR42.82805136
8TYK22.58220510
9ERN12.51413748
10PTK62.26924232
11SIK12.20785872
12JAK32.12149682
13STK102.09358770
14JAK12.06594784
15GRK62.05398575
16CDK122.03978180
17SMG11.86428436
18FGFR31.72821837
19LRRK21.68785647
20MAP2K31.67772997
21FLT31.63678998
22EPHB11.58373344
23ITK1.54419942
24RIPK11.51744960
25TBK11.49579001
26TTN1.48312047
27ZAP701.44997806
28MAP3K141.44327998
29MAP3K131.40807154
30BTK1.39497769
31TAOK31.35242864
32CSF1R1.33685030
33CDC42BPA1.33508157
34TGFBR21.29353194
35SIK21.21853335
36JAK21.18833730
37MAP3K11.16630509
38IKBKE1.14565756
39MAP3K71.13068537
40RPS6KB21.05634974
41CSK1.01840578
42MARK21.01754904
43KSR21.00914724
44IKBKB0.97875972
45HCK0.97429816
46KIT0.96341013
47CHUK0.96242153
48FGR0.94886240
49TAOK20.94728452
50MST1R0.94459406
51CDK60.94293817
52TAOK10.93975330
53PDGFRA0.92451992
54RPS6KA40.88532567
55MAPK110.87915145
56PIM10.87605826
57MAP3K20.87255775
58TXK0.86996135
59MTOR0.86990826
60CAMK1D0.86849581
61EPHA30.86204812
62CDK40.85856809
63LCK0.85560672
64SYK0.84875301
65NEK20.83228077
66MAP3K60.79857651
67FES0.78378302
68ALK0.77981899
69MAP3K30.77896279
70PRKD20.76425932
71WNK10.73684791
72RET0.73261838
73MARK30.72234314
74STK40.72001272
75PTK20.68647835
76SGK30.68023952
77SIK30.67792685
78SCYL20.67688860
79DDR20.67632177
80IRAK30.65021430
81MAP3K110.64403858
82IRAK10.64265942
83CAMK1G0.64242241
84PRKAA20.64194113
85YES10.63229336
86TYRO30.63096000
87MAP3K80.62740179
88RPS6KL10.62507252
89RPS6KC10.62507252
90PDGFRB0.61329659
91MAPK70.61254224
92PAK40.60814624
93MATK0.60694044
94RPS6KA20.60204980
95KDR0.59347927
96PDK10.59219473
97TEC0.57593558
98PRKCH0.56510512
99DYRK1B0.54215089
100BLK0.53990890
101IRAK20.53371624
102BRD40.52269891
103TGFBR10.52052130
104MAPKAPK30.51435393
105BCKDK0.51193773
106FGFR10.50966768
107MELK0.50852886
108NEK90.48498841
109EPHA20.48029736
110AKT30.46452610
111TRPM70.46232520
112BMX0.45942229
113NLK0.45137370
114TNK20.44936826
115FGFR20.43364095
116CDK90.40889103
117EGFR0.39129660
118STK30.38801513
119MAP2K20.38217893
120LYN0.38199519
121PDPK10.38009339
122LATS10.37829024
123IRAK40.36978039
124PAK20.36056880
125RIPK40.35953298
126PRKCQ0.35832910
127HIPK20.34560752
128ICK0.33884409
129MAPK120.32220568

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.15578046
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.93676746
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.83148471
4Other glycan degradation_Homo sapiens_hsa005112.55890636
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.29627911
6Arginine biosynthesis_Homo sapiens_hsa002202.25410097
7Primary immunodeficiency_Homo sapiens_hsa053402.07608291
8Caffeine metabolism_Homo sapiens_hsa002322.01358327
9Complement and coagulation cascades_Homo sapiens_hsa046101.94808687
10Staphylococcus aureus infection_Homo sapiens_hsa051501.86767394
11B cell receptor signaling pathway_Homo sapiens_hsa046621.86585062
12Tryptophan metabolism_Homo sapiens_hsa003801.83226271
13Lysine degradation_Homo sapiens_hsa003101.71108413
14Fatty acid degradation_Homo sapiens_hsa000711.66801047
15Selenocompound metabolism_Homo sapiens_hsa004501.51696900
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.50662594
17ABC transporters_Homo sapiens_hsa020101.47266897
18Osteoclast differentiation_Homo sapiens_hsa043801.38569454
19Leishmaniasis_Homo sapiens_hsa051401.35511534
20PPAR signaling pathway_Homo sapiens_hsa033201.33982568
21Bile secretion_Homo sapiens_hsa049761.33842033
22Insulin resistance_Homo sapiens_hsa049311.27432632
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26713035
24Allograft rejection_Homo sapiens_hsa053301.25170118
25Tuberculosis_Homo sapiens_hsa051521.24225796
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.21513210
27Antigen processing and presentation_Homo sapiens_hsa046121.20719731
28Graft-versus-host disease_Homo sapiens_hsa053321.18419813
29T cell receptor signaling pathway_Homo sapiens_hsa046601.18083962
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17035205
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.16399888
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14460437
33Toxoplasmosis_Homo sapiens_hsa051451.12810708
34Autoimmune thyroid disease_Homo sapiens_hsa053201.11940233
35Malaria_Homo sapiens_hsa051441.11569537
36Measles_Homo sapiens_hsa051621.11416013
37Renal cell carcinoma_Homo sapiens_hsa052111.11329048
38Fat digestion and absorption_Homo sapiens_hsa049751.10085230
39Chronic myeloid leukemia_Homo sapiens_hsa052201.09778668
40Endometrial cancer_Homo sapiens_hsa052131.07154472
41Pertussis_Homo sapiens_hsa051331.06563279
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.06133589
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05271459
44Acute myeloid leukemia_Homo sapiens_hsa052211.04201386
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.02180254
46Adipocytokine signaling pathway_Homo sapiens_hsa049200.99522523
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.95113207
48Bladder cancer_Homo sapiens_hsa052190.94325785
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94028183
50Amoebiasis_Homo sapiens_hsa051460.93910309
51Jak-STAT signaling pathway_Homo sapiens_hsa046300.93542080
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93150759
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91987121
54Fatty acid metabolism_Homo sapiens_hsa012120.91434275
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.90338846
56Histidine metabolism_Homo sapiens_hsa003400.86879762
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86158840
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85688314
59Choline metabolism in cancer_Homo sapiens_hsa052310.85336538
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85335916
61Thyroid cancer_Homo sapiens_hsa052160.85331263
62Lysosome_Homo sapiens_hsa041420.85077677
63Prostate cancer_Homo sapiens_hsa052150.84983445
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84306479
65Hematopoietic cell lineage_Homo sapiens_hsa046400.83942191
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83110241
67mTOR signaling pathway_Homo sapiens_hsa041500.82421315
68Inositol phosphate metabolism_Homo sapiens_hsa005620.82141607
69Biosynthesis of amino acids_Homo sapiens_hsa012300.81971597
70Small cell lung cancer_Homo sapiens_hsa052220.81060467
71Apoptosis_Homo sapiens_hsa042100.80819261
72Starch and sucrose metabolism_Homo sapiens_hsa005000.80710102
73FoxO signaling pathway_Homo sapiens_hsa040680.79803341
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79587898
75TNF signaling pathway_Homo sapiens_hsa046680.79213200
76One carbon pool by folate_Homo sapiens_hsa006700.78437308
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78122491
78HIF-1 signaling pathway_Homo sapiens_hsa040660.77918296
79Influenza A_Homo sapiens_hsa051640.77651803
80Insulin signaling pathway_Homo sapiens_hsa049100.76729044
81Peroxisome_Homo sapiens_hsa041460.76724723
82GnRH signaling pathway_Homo sapiens_hsa049120.76413506
83Fructose and mannose metabolism_Homo sapiens_hsa000510.76322652
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.75866290
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74251065
86Pancreatic cancer_Homo sapiens_hsa052120.74010082
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72820293
88Herpes simplex infection_Homo sapiens_hsa051680.71804913
89Prion diseases_Homo sapiens_hsa050200.71371090
90African trypanosomiasis_Homo sapiens_hsa051430.70532050
91Focal adhesion_Homo sapiens_hsa045100.70334924
92Non-small cell lung cancer_Homo sapiens_hsa052230.70209678
93ErbB signaling pathway_Homo sapiens_hsa040120.69178959
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69173717
95Platelet activation_Homo sapiens_hsa046110.68646256
96Type I diabetes mellitus_Homo sapiens_hsa049400.67971397
97Prolactin signaling pathway_Homo sapiens_hsa049170.67367458
98Chemical carcinogenesis_Homo sapiens_hsa052040.66518738
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.65787813
100beta-Alanine metabolism_Homo sapiens_hsa004100.65524620
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65488253
102Glycerolipid metabolism_Homo sapiens_hsa005610.65411943
103Hepatitis C_Homo sapiens_hsa051600.65318585
104Asthma_Homo sapiens_hsa053100.65069184
105Glioma_Homo sapiens_hsa052140.64770680
106Carbon metabolism_Homo sapiens_hsa012000.64501780
107Phenylalanine metabolism_Homo sapiens_hsa003600.63859852
108Hepatitis B_Homo sapiens_hsa051610.63603375
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63330671
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.62760087
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62699874
112Renin-angiotensin system_Homo sapiens_hsa046140.62629216
113Colorectal cancer_Homo sapiens_hsa052100.62285169
114Shigellosis_Homo sapiens_hsa051310.61937071
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60929936
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59644547
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.59585558
118Cyanoamino acid metabolism_Homo sapiens_hsa004600.59335262
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59181387
120Salmonella infection_Homo sapiens_hsa051320.58686892
121MicroRNAs in cancer_Homo sapiens_hsa052060.58680963
122Endocytosis_Homo sapiens_hsa041440.57988019
123Pentose phosphate pathway_Homo sapiens_hsa000300.57664290
124Chemokine signaling pathway_Homo sapiens_hsa040620.56933129
125Legionellosis_Homo sapiens_hsa051340.56562907
126Butanoate metabolism_Homo sapiens_hsa006500.56153276
127Adherens junction_Homo sapiens_hsa045200.55605775
128Retinol metabolism_Homo sapiens_hsa008300.55202394
129Propanoate metabolism_Homo sapiens_hsa006400.55183589
130Proteoglycans in cancer_Homo sapiens_hsa052050.54454360
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54203423
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54012662
133Galactose metabolism_Homo sapiens_hsa000520.53974441
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53893459
135Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53516429
136Viral myocarditis_Homo sapiens_hsa054160.52989803
137Notch signaling pathway_Homo sapiens_hsa043300.52603327
138Vitamin digestion and absorption_Homo sapiens_hsa049770.51956847
139AMPK signaling pathway_Homo sapiens_hsa041520.51896808
140Type II diabetes mellitus_Homo sapiens_hsa049300.51134389
141Viral carcinogenesis_Homo sapiens_hsa052030.50461060
142VEGF signaling pathway_Homo sapiens_hsa043700.49564059
143Cysteine and methionine metabolism_Homo sapiens_hsa002700.47061014
144HTLV-I infection_Homo sapiens_hsa051660.46439611

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