KHSRP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.90704586
2nuclear pore organization (GO:0006999)4.70173493
3protein localization to kinetochore (GO:0034501)4.50263615
4DNA unwinding involved in DNA replication (GO:0006268)4.48539797
5pre-miRNA processing (GO:0031054)4.45288399
6heterochromatin organization (GO:0070828)4.32891537
7regulation of mammary gland epithelial cell proliferation (GO:0033599)4.14738424
8planar cell polarity pathway involved in neural tube closure (GO:0090179)4.05388677
9regulation of gene silencing by RNA (GO:0060966)3.85114301
10regulation of posttranscriptional gene silencing (GO:0060147)3.85114301
11regulation of gene silencing by miRNA (GO:0060964)3.85114301
12proline biosynthetic process (GO:0006561)3.79274981
13negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.78911998
14protein localization to chromosome, centromeric region (GO:0071459)3.78877360
15mitotic sister chromatid segregation (GO:0000070)3.77019461
16regulation of NFAT protein import into nucleus (GO:0051532)3.75723546
17chromatin assembly (GO:0031497)3.73176856
18sister chromatid segregation (GO:0000819)3.72243505
19RNA stabilization (GO:0043489)3.71943239
20mRNA stabilization (GO:0048255)3.71943239
21pore complex assembly (GO:0046931)3.71811201
22dosage compensation (GO:0007549)3.71299860
23mitotic nuclear envelope disassembly (GO:0007077)3.70883843
24regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.67148990
25protein complex localization (GO:0031503)3.65233236
26Golgi transport vesicle coating (GO:0048200)3.63238386
27COPI coating of Golgi vesicle (GO:0048205)3.63238386
28negative regulation of histone methylation (GO:0031061)3.55750503
29cellular protein complex localization (GO:0034629)3.49850860
30regulation of translational fidelity (GO:0006450)3.49088263
31regulation of histone H3-K9 methylation (GO:0051570)3.48693035
32negative regulation of mRNA processing (GO:0050686)3.47373246
33adherens junction assembly (GO:0034333)3.45437773
34regulation of nucleobase-containing compound transport (GO:0032239)3.45227344
35negative regulation of RNA splicing (GO:0033119)3.43624590
36nuclear envelope disassembly (GO:0051081)3.43540728
37membrane disassembly (GO:0030397)3.43540728
38DNA duplex unwinding (GO:0032508)3.34849177
39positive regulation of chromosome segregation (GO:0051984)3.33178107
40DNA geometric change (GO:0032392)3.31275647
41protein-DNA complex disassembly (GO:0032986)3.30589739
42nucleosome disassembly (GO:0006337)3.30589739
43intracellular estrogen receptor signaling pathway (GO:0030520)3.29330523
44mitotic sister chromatid cohesion (GO:0007064)3.28933883
45DNA replication-dependent nucleosome assembly (GO:0006335)3.25435294
46DNA replication-dependent nucleosome organization (GO:0034723)3.25435294
47DNA topological change (GO:0006265)3.24831300
48positive regulation of gene expression, epigenetic (GO:0045815)3.23421318
49glucocorticoid receptor signaling pathway (GO:0042921)3.23118916
50chromosome condensation (GO:0030261)3.22789164
51mitotic chromosome condensation (GO:0007076)3.20697375
52focal adhesion assembly (GO:0048041)3.20623401
53cell-substrate adherens junction assembly (GO:0007045)3.20623401
54regulation of early endosome to late endosome transport (GO:2000641)3.20230349
55paraxial mesoderm development (GO:0048339)3.19292281
56negative regulation of mRNA metabolic process (GO:1903312)3.19024113
57histone arginine methylation (GO:0034969)3.17594917
58folic acid-containing compound biosynthetic process (GO:0009396)3.16195337
59maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.16001506
60regulation of gene silencing (GO:0060968)3.13471409
61protein retention in ER lumen (GO:0006621)3.12725895
62DNA replication initiation (GO:0006270)3.12700665
633-UTR-mediated mRNA stabilization (GO:0070935)3.11815963
64convergent extension (GO:0060026)3.10788704
65regulation of RNA export from nucleus (GO:0046831)3.10194112
66peptidyl-arginine methylation (GO:0018216)3.07301224
67peptidyl-arginine N-methylation (GO:0035246)3.07301224
68IMP biosynthetic process (GO:0006188)3.06922876
69histone H4-K12 acetylation (GO:0043983)3.06467775
70ribosomal small subunit biogenesis (GO:0042274)3.06003254
71positive regulation of mitotic sister chromatid separation (GO:1901970)3.03905334
72positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.03905334
73positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.03905334
74activation of Rac GTPase activity (GO:0032863)3.00239195
75maternal placenta development (GO:0001893)2.98728127
76regulation of chromatin binding (GO:0035561)2.98671473
77spliceosomal tri-snRNP complex assembly (GO:0000244)2.98145572
78regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.96860971
79protein export from nucleus (GO:0006611)2.96533288
80regulation of hippo signaling (GO:0035330)2.95653649
81regulation of sister chromatid cohesion (GO:0007063)2.94968550
82regulation of glucose import in response to insulin stimulus (GO:2001273)2.93245897
83regulation of mRNA stability (GO:0043488)2.92746667
84regulation of histone H3-K27 methylation (GO:0061085)2.92202807
85positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.91612346
86DNA strand elongation involved in DNA replication (GO:0006271)2.90751000
87negative regulation of erythrocyte differentiation (GO:0045647)2.88692902
88positive regulation of DNA-dependent DNA replication (GO:2000105)2.88486763
89cellular response to epidermal growth factor stimulus (GO:0071364)2.86129560
90trophectodermal cell differentiation (GO:0001829)2.86077033
91chromatin assembly or disassembly (GO:0006333)2.80879808
92protein localization to endosome (GO:0036010)2.79942176
93protein localization to microtubule (GO:0035372)2.79739532
94nuclear envelope organization (GO:0006998)2.79346386
95negative regulation of cell size (GO:0045792)2.78204279
96regulation of stem cell maintenance (GO:2000036)2.77962103
97DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.77602855
98regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.75868918
99response to UV-C (GO:0010225)2.75280976
100establishment of integrated proviral latency (GO:0075713)2.74937678
101DNA strand elongation (GO:0022616)2.74818213
102regulation of RNA stability (GO:0043487)2.74424497
103cytoskeletal anchoring at plasma membrane (GO:0007016)2.73610715
104establishment of apical/basal cell polarity (GO:0035089)2.73374685
105retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.73300826
106DNA conformation change (GO:0071103)2.69825603
107protein localization to chromosome (GO:0034502)2.68949044
108corticosteroid receptor signaling pathway (GO:0031958)2.68923115
109pentose-phosphate shunt (GO:0006098)2.68203950
110mitotic metaphase plate congression (GO:0007080)2.67289448
111regulation of translational termination (GO:0006449)2.65017011
112histone H2A monoubiquitination (GO:0035518)2.63568780
113apoptotic process involved in morphogenesis (GO:0060561)2.62944671
114negative regulation of histone modification (GO:0031057)2.62300518
115regulation of spindle organization (GO:0090224)2.62220517
116regulation of chromatin silencing (GO:0031935)2.62037515
117DNA packaging (GO:0006323)2.60590986
118peptidyl-arginine omega-N-methylation (GO:0035247)2.60006069
119DNA replication checkpoint (GO:0000076)2.60000444
120regulation of mitotic spindle organization (GO:0060236)2.59975641
121G1 DNA damage checkpoint (GO:0044783)2.58743598
122nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.58707919
123chromatin silencing (GO:0006342)2.58426248
124RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.58230075
125mRNA splicing, via spliceosome (GO:0000398)2.58230075
126negative regulation of gene silencing (GO:0060969)2.56672188
127telomere maintenance via semi-conservative replication (GO:0032201)2.56610148
128IMP metabolic process (GO:0046040)2.56044545
129* mRNA transport (GO:0051028)2.55936625
130negative regulation of chromatin modification (GO:1903309)2.54276919
131regulation of DNA damage checkpoint (GO:2000001)2.53231615
132Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.52285701
133* RNA splicing, via transesterification reactions (GO:0000375)2.52030535
134embryonic process involved in female pregnancy (GO:0060136)2.51812586
135regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.50608965
136kinetochore organization (GO:0051383)2.50112281
137formation of translation preinitiation complex (GO:0001731)2.50085392
138polarized epithelial cell differentiation (GO:0030859)2.49123982
139regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.49059363
140positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.49059363
141proline metabolic process (GO:0006560)2.48619307
142DNA damage response, signal transduction resulting in transcription (GO:0042772)2.48619137
143negative regulation of gene expression, epigenetic (GO:0045814)2.48462243
144negative regulation of histone acetylation (GO:0035067)2.48311249
145positive regulation of SMAD protein import into nucleus (GO:0060391)2.48266008
146mitotic G1 DNA damage checkpoint (GO:0031571)2.47986321
147alternative mRNA splicing, via spliceosome (GO:0000380)2.47569638

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.92724564
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.24312719
3* MYC_22102868_ChIP-Seq_BL_Human3.49212997
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.35867520
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.32925003
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.03409132
7* MYC_18555785_ChIP-Seq_MESCs_Mouse2.68550148
8* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.62314833
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.44604639
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.38857079
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.34491855
12VDR_21846776_ChIP-Seq_THP-1_Human2.33066037
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.25888772
14SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.18542061
15LXR_22292898_ChIP-Seq_THP-1_Human2.09094454
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.01569153
17E2F1_21310950_ChIP-Seq_MCF-7_Human1.99463962
18TCF7_22412390_ChIP-Seq_EML_Mouse1.92648704
19MYC_19030024_ChIP-ChIP_MESCs_Mouse1.85335548
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.84316255
21KDM2B_26808549_Chip-Seq_DND41_Human1.74836175
22CIITA_25753668_ChIP-Seq_RAJI_Human1.72775827
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.72736508
24KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.72630021
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70491840
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.65486966
27KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.65486966
28KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.65486966
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59947950
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.58792634
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.57176739
32XRN2_22483619_ChIP-Seq_HELA_Human1.57120305
33CLOCK_20551151_ChIP-Seq_293T_Human1.56265979
34KDM2B_26808549_Chip-Seq_K562_Human1.55690865
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54973530
36AR_21909140_ChIP-Seq_LNCAP_Human1.54668798
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54594479
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54575220
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.53728161
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48501903
41ZFP281_27345836_Chip-Seq_ESCs_Mouse1.47370840
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.46708629
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44976796
44* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44494018
45UTX_26944678_Chip-Seq_JUKART_Human1.43666658
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.43305470
47* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42320637
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40174842
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40012007
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.39946391
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.39926765
52MAF_26560356_Chip-Seq_TH1_Human1.39759769
53KDM5A_27292631_Chip-Seq_BREAST_Human1.38393278
54SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.37936709
55ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.37845042
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37451006
57* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36233561
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34935549
59ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32897068
60TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32484187
61* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30942705
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30719848
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30429382
64SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.30403617
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29760215
66TCF3_18692474_ChIP-Seq_MEFs_Mouse1.28105260
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27913746
68* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27601260
69* NANOG_21062744_ChIP-ChIP_HESCs_Human1.27022084
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.26541437
71UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26422125
72ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22060724
73* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22059871
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21742767
75NCOR1_26117541_ChIP-Seq_K562_Human1.21414666
76NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21387409
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21196437
78P68_20966046_ChIP-Seq_HELA_Human1.20574243
79KDM2B_26808549_Chip-Seq_JURKAT_Human1.20236319
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19298482
81SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18332994
82SCL_19346495_ChIP-Seq_HPC-7_Human1.17777419
83ERG_21242973_ChIP-ChIP_JURKAT_Human1.16029816
84TCF3_18692474_ChIP-Seq_MESCs_Mouse1.15928440
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15201640
86CREB1_26743006_Chip-Seq_LNCaP_Human1.14635366
87MYB_26560356_Chip-Seq_TH1_Human1.12532304
88VDR_24763502_ChIP-Seq_THP-1_Human1.11758327
89* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11239652
90* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10679511
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10653357
92SA1_27219007_Chip-Seq_ERYTHROID_Human1.10601141
93SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.09584916
94* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08422814
95TTF2_22483619_ChIP-Seq_HELA_Human1.08353335
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07143432
97* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.05894708
98MAF_26560356_Chip-Seq_TH2_Human1.05724481
99CHD1_26751641_Chip-Seq_LNCaP_Human1.05235815
100NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.04995743
101SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02838572
102SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02602496
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02251847
104P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02165823
105POU5F1_16518401_ChIP-PET_MESCs_Mouse1.01434962
106SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01156130
107RACK7_27058665_Chip-Seq_MCF-7_Human1.00832947
108CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00704260
109NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99977607
110* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99573607
111KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99405732
112DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99197697
113TP53_22127205_ChIP-Seq_IMR90_Human0.99069598
114* ATF3_27146783_Chip-Seq_COLON_Human0.99056103
115HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98805233
116BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97765723
117TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97539919
118RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96968911
119SMC4_20622854_ChIP-Seq_HELA_Human0.96405776
120RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96320513
121STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.95607368
122* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95531638
123* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94997900
124RUNX1_22412390_ChIP-Seq_EML_Mouse0.94840190
125TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92757351
126FOXP3_21729870_ChIP-Seq_TREG_Human0.92565821
127* PKCTHETA_26484144_Chip-Seq_BREAST_Human0.92447983
128EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92156110
129SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91156784
130* MYB_26560356_Chip-Seq_TH2_Human0.91129568
131YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90482965
132FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.89857043
133EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89236226
134ZNF263_19887448_ChIP-Seq_K562_Human0.87447703

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology3.12695286
2MP0008057_abnormal_DNA_replication2.97994187
3MP0010094_abnormal_chromosome_stability2.83704629
4MP0010352_gastrointestinal_tract_polyps2.76259105
5MP0005076_abnormal_cell_differentiation2.74344394
6MP0003077_abnormal_cell_cycle2.69639708
7MP0004957_abnormal_blastocyst_morpholog2.62703679
8MP0003705_abnormal_hypodermis_morpholog2.61427214
9MP0003693_abnormal_embryo_hatching2.59786653
10MP0005451_abnormal_body_composition2.16205374
11MP0004858_abnormal_nervous_system2.14350524
12MP0000350_abnormal_cell_proliferation2.09837677
13MP0010030_abnormal_orbit_morphology2.08647398
14MP0002396_abnormal_hematopoietic_system2.06442811
15MP0001730_embryonic_growth_arrest2.02763216
16MP0009278_abnormal_bone_marrow2.02632797
17MP0010307_abnormal_tumor_latency2.00921963
18MP0010234_abnormal_vibrissa_follicle1.98735356
19MP0008007_abnormal_cellular_replicative1.97443510
20MP0001849_ear_inflammation1.94842615
21MP0004197_abnormal_fetal_growth/weight/1.88578576
22MP0009053_abnormal_anal_canal1.86275189
23MP0005380_embryogenesis_phenotype1.85944642
24MP0001672_abnormal_embryogenesis/_devel1.85944642
25MP0000566_synostosis1.81667918
26MP0002084_abnormal_developmental_patter1.80635875
27MP0004233_abnormal_muscle_weight1.78591177
28MP0002085_abnormal_embryonic_tissue1.76225721
29MP0003984_embryonic_growth_retardation1.74679785
30MP0002088_abnormal_embryonic_growth/wei1.73211783
31MP0003123_paternal_imprinting1.73128533
32MP0004808_abnormal_hematopoietic_stem1.72656538
33MP0000678_abnormal_parathyroid_gland1.72260268
34MP0001697_abnormal_embryo_size1.68243405
35MP0002086_abnormal_extraembryonic_tissu1.67348812
36MP0005409_darkened_coat_color1.62671236
37MP0000537_abnormal_urethra_morphology1.53445043
38MP0001545_abnormal_hematopoietic_system1.52770882
39MP0005397_hematopoietic_system_phenotyp1.52770882
40MP0001346_abnormal_lacrimal_gland1.52286450
41MP0002089_abnormal_postnatal_growth/wei1.52049899
42MP0003567_abnormal_fetal_cardiomyocyte1.49163078
43MP0003566_abnormal_cell_adhesion1.48955616
44MP0000490_abnormal_crypts_of1.44670056
45MP0002653_abnormal_ependyma_morphology1.44662872
46MP0008932_abnormal_embryonic_tissue1.44347559
47MP0003121_genomic_imprinting1.41200058
48MP0002080_prenatal_lethality1.41162334
49MP0000428_abnormal_craniofacial_morphol1.40259270
50MP0003119_abnormal_digestive_system1.39212633
51MP0008438_abnormal_cutaneous_collagen1.38818977
52MP0002877_abnormal_melanocyte_morpholog1.33299161
53MP0000733_abnormal_muscle_development1.32762124
54MP0000003_abnormal_adipose_tissue1.30036353
55MP0005501_abnormal_skin_physiology1.29554907
56MP0002796_impaired_skin_barrier1.28934639
57MP0004272_abnormal_basement_membrane1.28156237
58MP0008058_abnormal_DNA_repair1.26949848
59MP0001293_anophthalmia1.26647640
60MP0003890_abnormal_embryonic-extraembry1.25521449
61MP0003115_abnormal_respiratory_system1.24133762
62MP0005666_abnormal_adipose_tissue1.23821175
63MP0000703_abnormal_thymus_morphology1.22538157
64MP0003941_abnormal_skin_development1.21088288
65MP0001915_intracranial_hemorrhage1.20702980
66MP0002009_preneoplasia1.18789037
67MP0002697_abnormal_eye_size1.17439920
68MP0000313_abnormal_cell_death1.13056805
69MP0002925_abnormal_cardiovascular_devel1.12788685
70MP0002249_abnormal_larynx_morphology1.11500416
71MP0005023_abnormal_wound_healing1.10594062
72MP0003935_abnormal_craniofacial_develop1.10479916
73MP0005375_adipose_tissue_phenotype1.10465692
74MP0002019_abnormal_tumor_incidence1.09857365
75MP0005058_abnormal_lysosome_morphology1.09501387
76MP0002092_abnormal_eye_morphology1.08868803
77MP0003763_abnormal_thymus_physiology1.07971809
78MP0003385_abnormal_body_wall1.07766211
79MP0009703_decreased_birth_body1.07258409
80MP0000432_abnormal_head_morphology1.07227970
81MP0005621_abnormal_cell_physiology1.06792319
82MP0009333_abnormal_splenocyte_physiolog1.04556682
83MP0002111_abnormal_tail_morphology1.03740768
84MP0003937_abnormal_limbs/digits/tail_de1.03644965
85MP0004264_abnormal_extraembryonic_tissu1.03256695
86MP0002398_abnormal_bone_marrow1.02611600
87MP0003300_gastrointestinal_ulcer1.02226590
88MP0009672_abnormal_birth_weight1.00537582
89MP0005623_abnormal_meninges_morphology0.99328379
90MP0000049_abnormal_middle_ear0.97220193
91MP0000534_abnormal_ureter_morphology0.96496540
92MP0003303_peritoneal_inflammation0.96170264
93MP0003786_premature_aging0.95607264
94MP0002060_abnormal_skin_morphology0.94801307
95MP0005367_renal/urinary_system_phenotyp0.93618446
96MP0000516_abnormal_urinary_system0.93618446
97MP0002722_abnormal_immune_system0.92199021
98MP0008260_abnormal_autophagy0.91005425
99MP0001286_abnormal_eye_development0.90952172
100MP0008770_decreased_survivor_rate0.90423699
101MP0003755_abnormal_palate_morphology0.89178685
102MP0008877_abnormal_DNA_methylation0.88558346
103MP0002932_abnormal_joint_morphology0.87584175
104MP0003942_abnormal_urinary_system0.85351833
105MP0000762_abnormal_tongue_morphology0.84396460
106MP0009379_abnormal_foot_pigmentation0.83335166
107MP0000579_abnormal_nail_morphology0.82115100
108MP0005384_cellular_phenotype0.81299798
109MP0000689_abnormal_spleen_morphology0.81225195
110MP0003861_abnormal_nervous_system0.79519995
111MP0005257_abnormal_intraocular_pressure0.79132820
112MP0004185_abnormal_adipocyte_glucose0.79090626
113MP0002116_abnormal_craniofacial_bone0.78804097
114MP0000858_altered_metastatic_potential0.78728253
115MP0000266_abnormal_heart_morphology0.78650557
116MP0010630_abnormal_cardiac_muscle0.78147654
117MP0001348_abnormal_lacrimal_gland0.77806833
118MP0001784_abnormal_fluid_regulation0.77702888
119MP0002282_abnormal_trachea_morphology0.77456305
120MP0003315_abnormal_perineum_morphology0.76848427
121MP0003453_abnormal_keratinocyte_physiol0.76571257
122MP0006054_spinal_hemorrhage0.75937092
123MP0000759_abnormal_skeletal_muscle0.75061017
124MP0000477_abnormal_intestine_morphology0.74454622
125MP0004087_abnormal_muscle_fiber0.74209538
126MP0008789_abnormal_olfactory_epithelium0.74193583
127MP0000747_muscle_weakness0.73110383
128MP0002081_perinatal_lethality0.72637771
129MP0002114_abnormal_axial_skeleton0.72042473
130MP0003091_abnormal_cell_migration0.69794547
131MP0000467_abnormal_esophagus_morphology0.68959514
132MP0001340_abnormal_eyelid_morphology0.68691952
133MP0002098_abnormal_vibrissa_morphology0.68670954
134MP0001216_abnormal_epidermal_layer0.68573353

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.13799835
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.13799835
3Insomnia (HP:0100785)3.11988194
4Selective tooth agenesis (HP:0001592)2.96442661
5Abnormality of the fingertips (HP:0001211)2.94920805
6Ependymoma (HP:0002888)2.81496786
7Disproportionate tall stature (HP:0001519)2.77505301
8Long palpebral fissure (HP:0000637)2.68347814
9Hyperacusis (HP:0010780)2.62831324
10Long eyelashes (HP:0000527)2.54084707
11Increased nuchal translucency (HP:0010880)2.52043941
12Rib fusion (HP:0000902)2.49521289
13Renal duplication (HP:0000075)2.46259712
14Dysmetric saccades (HP:0000641)2.45796840
15Premature rupture of membranes (HP:0001788)2.44056257
16Ectopic kidney (HP:0000086)2.40612264
17Deviation of the thumb (HP:0009603)2.38947372
18Achilles tendon contracture (HP:0001771)2.37826892
19Broad face (HP:0000283)2.35117450
20Asymmetry of the thorax (HP:0001555)2.31569518
21Proximal placement of thumb (HP:0009623)2.31438249
22Medulloblastoma (HP:0002885)2.30248804
23Astrocytoma (HP:0009592)2.29978324
24Abnormality of the astrocytes (HP:0100707)2.29978324
25Abnormal number of incisors (HP:0011064)2.29377615
26Patellar aplasia (HP:0006443)2.28485478
27Distal lower limb amyotrophy (HP:0008944)2.28395440
28Chromsome breakage (HP:0040012)2.27668298
29Abnormality of the 4th metacarpal (HP:0010012)2.27549815
30Elfin facies (HP:0004428)2.25385218
31Ankyloglossia (HP:0010296)2.24390368
32Obstructive sleep apnea (HP:0002870)2.22585615
33Shallow orbits (HP:0000586)2.22019821
34Broad distal phalanx of finger (HP:0009836)2.20724038
35Turricephaly (HP:0000262)2.20196056
36High anterior hairline (HP:0009890)2.19873921
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.18380620
38Pointed chin (HP:0000307)2.17681235
39Deep palmar crease (HP:0006191)2.16490268
40Aplasia/Hypoplasia of the patella (HP:0006498)2.15188510
41Volvulus (HP:0002580)2.12874345
42Centrally nucleated skeletal muscle fibers (HP:0003687)2.12638517
43Ulnar bowing (HP:0003031)2.10687052
44Arnold-Chiari malformation (HP:0002308)2.10285011
45Intestinal fistula (HP:0100819)2.10058689
46Skin tags (HP:0010609)2.09694546
47Trismus (HP:0000211)2.08444971
48Abnormality of the calcaneus (HP:0008364)2.07588788
49Neoplasm of the oral cavity (HP:0100649)2.07544467
50Broad thumb (HP:0011304)2.07458030
51Patellar dislocation (HP:0002999)2.07086012
52Supernumerary ribs (HP:0005815)2.06756613
53Abnormality of the Achilles tendon (HP:0005109)2.05673631
54Progressive muscle weakness (HP:0003323)2.05240601
55Rhabdomyosarcoma (HP:0002859)2.04466322
56Syringomyelia (HP:0003396)2.04369598
57Spinal cord lesions (HP:0100561)2.04369598
58Sparse lateral eyebrow (HP:0005338)2.03653673
59Basal cell carcinoma (HP:0002671)2.03372932
60Neoplasm of striated muscle (HP:0009728)2.00450439
61Facial hemangioma (HP:0000329)2.00207798
62Broad palm (HP:0001169)2.00063216
63Abnormality of the phalanges of the hallux (HP:0010057)1.99727038
64Trigonocephaly (HP:0000243)1.99510699
65Missing ribs (HP:0000921)1.99111574
66Esophageal atresia (HP:0002032)1.99085892
67Thin ribs (HP:0000883)1.96559169
68Prominent nose (HP:0000448)1.94814043
69Flat acetabular roof (HP:0003180)1.93837967
70Pseudobulbar signs (HP:0002200)1.93643948
71Atresia of the external auditory canal (HP:0000413)1.92785151
72Abnormality of oral frenula (HP:0000190)1.92255387
73Preauricular skin tag (HP:0000384)1.90923836
74Short 5th finger (HP:0009237)1.90796423
75Short 1st metacarpal (HP:0010034)1.89626136
76Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.89626136
77Back pain (HP:0003418)1.89070977
78Supernumerary bones of the axial skeleton (HP:0009144)1.88668027
79Urethral obstruction (HP:0000796)1.87934249
80Lower limb amyotrophy (HP:0007210)1.87919069
81Increased connective tissue (HP:0009025)1.87398072
82High pitched voice (HP:0001620)1.86712149
83Increased density of long bones (HP:0006392)1.86375113
84Genu recurvatum (HP:0002816)1.85906780
85Truncus arteriosus (HP:0001660)1.83982991
86Short phalanx of the thumb (HP:0009660)1.83292199
87Absent radius (HP:0003974)1.83196593
88Abnormality of the thoracic spine (HP:0100711)1.82923961
89Short humerus (HP:0005792)1.82561407
90Cerebral aneurysm (HP:0004944)1.82127249
91Cafe-au-lait spot (HP:0000957)1.81397192
92Aplasia/hypoplasia of the humerus (HP:0006507)1.80977238
93Abnormality of the labia minora (HP:0012880)1.79433956
94Protrusio acetabuli (HP:0003179)1.79417961
95Skull defect (HP:0001362)1.78719064
96Distal upper limb amyotrophy (HP:0007149)1.78527602
97Upper limb amyotrophy (HP:0009129)1.78527602
98Gastrointestinal carcinoma (HP:0002672)1.77768595
99Malignant gastrointestinal tract tumors (HP:0006749)1.77768595
100Renovascular hypertension (HP:0100817)1.77236845
101Anal stenosis (HP:0002025)1.77072937
102Heterotopia (HP:0002282)1.76800303
103Vertebral compression fractures (HP:0002953)1.76205588
104Impulsivity (HP:0100710)1.76041967
105Shawl scrotum (HP:0000049)1.75706786
106Aplasia/Hypoplasia of the sternum (HP:0006714)1.75096589
107Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.75025275
108Overlapping toe (HP:0001845)1.74513385
109Spina bifida occulta (HP:0003298)1.73955225
110Reticulocytopenia (HP:0001896)1.73639411
111Bowel incontinence (HP:0002607)1.73267520
112Premature skin wrinkling (HP:0100678)1.73220310
113Aplasia involving forearm bones (HP:0009822)1.72788985
114Absent forearm bone (HP:0003953)1.72788985
115Glioma (HP:0009733)1.72381759
116Biconcave vertebral bodies (HP:0004586)1.72230521
117Bladder diverticulum (HP:0000015)1.71704756
118Abnormal gallbladder physiology (HP:0012438)1.71362455
119Cholecystitis (HP:0001082)1.71362455
120Abnormality of the distal phalanx of the thumb (HP:0009617)1.70951198
121Absent thumb (HP:0009777)1.70919012
122Meckel diverticulum (HP:0002245)1.70208611
123Advanced eruption of teeth (HP:0006288)1.69512900
124Flat cornea (HP:0007720)1.69300105
125Mitral regurgitation (HP:0001653)1.68470573
126Myelodysplasia (HP:0002863)1.68449958
127Ankle contracture (HP:0006466)1.68264442
128Abnormality of the ileum (HP:0001549)1.67719124
129Abnormality of the salivary glands (HP:0010286)1.66997700
130Septate vagina (HP:0001153)1.66947029
131Vertebral fusion (HP:0002948)1.66485548
132Multiple enchondromatosis (HP:0005701)1.66335260
133Broad phalanges of the hand (HP:0009768)1.65236700
134Large earlobe (HP:0009748)1.64966512
135Metaphyseal cupping (HP:0003021)1.64310807
136Persistence of primary teeth (HP:0006335)1.63307971
137Abnormal large intestine physiology (HP:0012700)1.62760990
138Cutis marmorata (HP:0000965)1.61873923
139Midface retrusion (HP:0011800)1.61404171
140Insidious onset (HP:0003587)1.61274237
141Termporal pattern (HP:0011008)1.61274237
142Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.61157282
143Macroorchidism (HP:0000053)1.60927744
144Reticulocytosis (HP:0001923)1.60829812
145Overriding aorta (HP:0002623)1.60469201
146Glossoptosis (HP:0000162)1.60314378
147Spinal rigidity (HP:0003306)1.60233009
148Fragile skin (HP:0001030)1.59993515
149Abnormality of the peritoneum (HP:0002585)1.59839410
150Unilateral renal agenesis (HP:0000122)1.59683916
151Hypercalcemia (HP:0003072)1.59327707
152Flared metaphyses (HP:0003015)1.58991603
153Partial duplication of thumb phalanx (HP:0009944)1.58879630
154Tracheoesophageal fistula (HP:0002575)1.58304055
155Precocious puberty (HP:0000826)1.58187270
156Sparse scalp hair (HP:0002209)1.57965393
157Vertebral arch anomaly (HP:0008438)1.57748562
158Amaurosis fugax (HP:0100576)1.57535385
159Sandal gap (HP:0001852)1.56925326
160Depressed nasal tip (HP:0000437)1.56675192
161Abnormality of the 1st metacarpal (HP:0010009)1.55134296
162Bowel diverticulosis (HP:0005222)1.54954326
163Abnormality of chromosome stability (HP:0003220)1.54470216
164Abnormality of the distal phalanges of the toes (HP:0010182)1.54317645
165Dislocated radial head (HP:0003083)1.54303749
166Breast hypoplasia (HP:0003187)1.54237256
167Short thumb (HP:0009778)1.53907870
168Duplication of thumb phalanx (HP:0009942)1.53906273
169Abnormality of the radial head (HP:0003995)1.52216848
170Partial duplication of the phalanx of hand (HP:0009999)1.51901171

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.15257944
2SMG14.42884058
3EEF2K3.99348372
4MAP3K103.40151138
5CDC73.32622241
6PRPF4B2.90230551
7TRIB32.74397139
8PKN22.67626114
9ICK2.29161826
10NEK22.26433576
11IRAK32.15307888
12LATS12.03346147
13STK101.83834065
14BRD41.81219558
15CDK71.79215110
16CDK41.76784741
17FGFR41.71333269
18RPS6KB21.69090184
19NME21.53921739
20ALK1.53522807
21MAP4K11.53425083
22MKNK21.52458333
23MKNK11.49084421
24TTK1.48602071
25CDK61.48229545
26MTOR1.45007142
27BMX1.41466797
28STK41.38432165
29WEE11.36457874
30LATS21.32320749
31PIM11.29128908
32PDGFRA1.28059155
33SRPK11.23499258
34STK31.23306089
35CHEK11.22438151
36MAP3K81.19902688
37ATR1.18281037
38KSR21.15001075
39CLK11.10689094
40MAP3K91.10396393
41CHEK21.07709022
42PLK11.05665119
43PRKD31.04593600
44PTK61.04568646
45TAOK21.03063745
46AURKB1.02726589
47GRK61.02331028
48NEK11.01877825
49PAK21.01620854
50MAP3K130.99892517
51LRRK20.99800504
52TTN0.99110549
53CDK20.98669181
54TESK20.95552843
55BRAF0.92599610
56TLK10.91929983
57PAK40.91793536
58TAOK10.90557669
59RPS6KA40.88180208
60EPHA20.88113018
61* ATM0.85643212
62ARAF0.85215444
63NTRK10.84156576
64PTK20.83676929
65CAMK1D0.81321295
66SIK10.81210612
67CHUK0.80132367
68SIK20.79119365
69TYRO30.75829478
70FLT30.75385591
71MAPK110.72432390
72RIPK10.71979355
73BUB10.71661057
74MST1R0.70898501
75JAK30.69971139
76VRK20.69506269
77TSSK60.69450629
78PASK0.69224336
79TAF10.67992889
80DDR20.67370139
81DMPK0.66734882
82TRPM70.66334826
83SCYL20.66152122
84CDK90.66067710
85CDK80.64970961
86HIPK20.64706749
87CDK10.64277939
88RPS6KA20.62978581
89RPS6KL10.62522071
90RPS6KC10.62522071
91MAP2K30.61735083
92PRKD20.61454741
93CDC42BPA0.61348029
94CDK11A0.60859851
95ERN10.60720949
96PLK30.59719595
97PDGFRB0.58570041
98MAP2K20.57190725
99BRSK20.56940167
100RPS6KA60.56760106
101CDK150.56420414
102RPS6KA10.55494111
103MARK20.55312108
104MELK0.53600439
105* MAPK140.53516993
106IRAK20.53184880
107CAMK1G0.52195381
108FGFR30.51956633
109CSNK1D0.51106763
110LMTK20.50914197
111CDK180.50065283
112BTK0.49988376
113MAPK10.48988520
114MAPKAPK20.48547585
115CSF1R0.46254365
116* AKT10.45122867
117TGFBR10.45052956
118FGFR10.44895351
119AURKA0.44277923
120MAP3K10.44154550
121PDPK10.43634991
122PAK10.43319854
123CSNK1E0.43310795
124CDK140.43021497
125DYRK1B0.42900861
126CAMK40.41921935
127DYRK30.40888737
128BRSK10.40698349
129GSK3B0.39421943
130ILK0.39082209
131PRKDC0.38887537
132CSK0.38851281
133MAPK100.38429471
134TESK10.37113199
135MET0.36829912
136KDR0.35196840
137MAP3K140.34306235
138RET0.32342514

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.22607534
2Mismatch repair_Homo sapiens_hsa034302.65781754
3Spliceosome_Homo sapiens_hsa030402.64477692
4Cell cycle_Homo sapiens_hsa041102.43098969
5RNA transport_Homo sapiens_hsa030132.41617312
6One carbon pool by folate_Homo sapiens_hsa006702.31021901
7mRNA surveillance pathway_Homo sapiens_hsa030152.30140430
8Base excision repair_Homo sapiens_hsa034102.19618494
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.19582387
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.89344375
11Notch signaling pathway_Homo sapiens_hsa043301.82199617
12Biosynthesis of amino acids_Homo sapiens_hsa012301.80696490
13MicroRNAs in cancer_Homo sapiens_hsa052061.79788028
14Chronic myeloid leukemia_Homo sapiens_hsa052201.77603573
15Homologous recombination_Homo sapiens_hsa034401.73496180
16Pentose phosphate pathway_Homo sapiens_hsa000301.61297675
17Small cell lung cancer_Homo sapiens_hsa052221.54889180
18Fanconi anemia pathway_Homo sapiens_hsa034601.54321245
19Basal cell carcinoma_Homo sapiens_hsa052171.53460392
20Nucleotide excision repair_Homo sapiens_hsa034201.51990782
21p53 signaling pathway_Homo sapiens_hsa041151.51299049
22Prion diseases_Homo sapiens_hsa050201.45573419
23Viral carcinogenesis_Homo sapiens_hsa052031.45150847
24Lysine degradation_Homo sapiens_hsa003101.44778602
25Transcriptional misregulation in cancer_Homo sapiens_hsa052021.43372810
26HTLV-I infection_Homo sapiens_hsa051661.38040180
27RNA degradation_Homo sapiens_hsa030181.36281943
28Adherens junction_Homo sapiens_hsa045201.34906331
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.34644204
30Acute myeloid leukemia_Homo sapiens_hsa052211.34503909
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.34288366
32Hippo signaling pathway_Homo sapiens_hsa043901.27605875
33Ribosome_Homo sapiens_hsa030101.26686701
34Thyroid cancer_Homo sapiens_hsa052161.25691748
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.25409533
36Herpes simplex infection_Homo sapiens_hsa051681.25167677
37Systemic lupus erythematosus_Homo sapiens_hsa053221.24811331
38Colorectal cancer_Homo sapiens_hsa052101.22495452
39mTOR signaling pathway_Homo sapiens_hsa041501.22356612
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21888791
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21302268
42Non-small cell lung cancer_Homo sapiens_hsa052231.19306978
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.14718286
44Endometrial cancer_Homo sapiens_hsa052131.12468381
45Primary immunodeficiency_Homo sapiens_hsa053401.11884341
46Bladder cancer_Homo sapiens_hsa052191.09271465
47Insulin signaling pathway_Homo sapiens_hsa049101.09185703
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08743463
49Prostate cancer_Homo sapiens_hsa052151.08197341
50Proteoglycans in cancer_Homo sapiens_hsa052051.07135431
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04358061
52Central carbon metabolism in cancer_Homo sapiens_hsa052301.04035558
53Fructose and mannose metabolism_Homo sapiens_hsa000511.02684101
54Antigen processing and presentation_Homo sapiens_hsa046121.00928398
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00274678
56Viral myocarditis_Homo sapiens_hsa054160.99968979
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98846950
58Non-homologous end-joining_Homo sapiens_hsa034500.98634896
59Hepatitis B_Homo sapiens_hsa051610.97337550
60Hedgehog signaling pathway_Homo sapiens_hsa043400.96925271
61TGF-beta signaling pathway_Homo sapiens_hsa043500.96803074
62B cell receptor signaling pathway_Homo sapiens_hsa046620.96667213
63Epstein-Barr virus infection_Homo sapiens_hsa051690.96553071
64Pancreatic cancer_Homo sapiens_hsa052120.95982333
65Carbon metabolism_Homo sapiens_hsa012000.94778568
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93384384
67Sulfur relay system_Homo sapiens_hsa041220.92444335
68Other glycan degradation_Homo sapiens_hsa005110.91537493
69Pathways in cancer_Homo sapiens_hsa052000.91528077
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90753681
71Wnt signaling pathway_Homo sapiens_hsa043100.88438554
72Apoptosis_Homo sapiens_hsa042100.86314921
73Basal transcription factors_Homo sapiens_hsa030220.84506647
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.84169091
75Focal adhesion_Homo sapiens_hsa045100.83419404
76Measles_Homo sapiens_hsa051620.82399632
77Estrogen signaling pathway_Homo sapiens_hsa049150.81945070
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81394752
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81260706
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80450008
81RNA polymerase_Homo sapiens_hsa030200.79844181
82Glioma_Homo sapiens_hsa052140.79706715
83Galactose metabolism_Homo sapiens_hsa000520.79578591
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78851865
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78423131
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.77047634
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76699959
88Vitamin B6 metabolism_Homo sapiens_hsa007500.76501455
89HIF-1 signaling pathway_Homo sapiens_hsa040660.75636742
90T cell receptor signaling pathway_Homo sapiens_hsa046600.74804134
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73580035
92Melanogenesis_Homo sapiens_hsa049160.71999393
93Toxoplasmosis_Homo sapiens_hsa051450.71205884
94Renal cell carcinoma_Homo sapiens_hsa052110.70490917
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.69886230
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.68961495
97Oocyte meiosis_Homo sapiens_hsa041140.67878164
98Melanoma_Homo sapiens_hsa052180.67005588
99Choline metabolism in cancer_Homo sapiens_hsa052310.66752745
100Long-term potentiation_Homo sapiens_hsa047200.64947213
101GnRH signaling pathway_Homo sapiens_hsa049120.64795278
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.64696287
103Shigellosis_Homo sapiens_hsa051310.63802777
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.63799900
105VEGF signaling pathway_Homo sapiens_hsa043700.62970378
106FoxO signaling pathway_Homo sapiens_hsa040680.62527679
107Leishmaniasis_Homo sapiens_hsa051400.62151166
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60741984
109Pyrimidine metabolism_Homo sapiens_hsa002400.60703275
110Prolactin signaling pathway_Homo sapiens_hsa049170.60298991
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60047667
112Tight junction_Homo sapiens_hsa045300.59422580
113Inositol phosphate metabolism_Homo sapiens_hsa005620.57418040
114Influenza A_Homo sapiens_hsa051640.57405581
115Alcoholism_Homo sapiens_hsa050340.56529049
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56018483
117N-Glycan biosynthesis_Homo sapiens_hsa005100.52576848
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52491980
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51592912
120ECM-receptor interaction_Homo sapiens_hsa045120.51475677
121Platelet activation_Homo sapiens_hsa046110.49800535
122Osteoclast differentiation_Homo sapiens_hsa043800.49560877
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49500484
124Hematopoietic cell lineage_Homo sapiens_hsa046400.48910266
125ErbB signaling pathway_Homo sapiens_hsa040120.48591704
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48260779
127Dorso-ventral axis formation_Homo sapiens_hsa043200.47596032
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.47515653
129Hepatitis C_Homo sapiens_hsa051600.46753484
130Gap junction_Homo sapiens_hsa045400.46268333
131AMPK signaling pathway_Homo sapiens_hsa041520.42260621
132Rap1 signaling pathway_Homo sapiens_hsa040150.41533423
133MAPK signaling pathway_Homo sapiens_hsa040100.41398854

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