KIAA0040

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.97527884
2negative regulation of cell killing (GO:0031342)5.67740293
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.67740293
4positive regulation of gamma-delta T cell activation (GO:0046645)5.65459967
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.46794024
6antigen processing and presentation of endogenous antigen (GO:0019883)5.21120879
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.19159120
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.19159120
9modulation by symbiont of host immune response (GO:0052553)5.19159120
10positive regulation by symbiont of host defense response (GO:0052509)5.19159120
11modulation by symbiont of host defense response (GO:0052031)5.19159120
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.19159120
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.07671949
14macrophage activation involved in immune response (GO:0002281)4.71304712
15regulation of B cell receptor signaling pathway (GO:0050855)4.54693837
16detection of other organism (GO:0098543)4.49747192
17regulation of gamma-delta T cell activation (GO:0046643)4.30716967
18cellular response to type I interferon (GO:0071357)4.28352993
19type I interferon signaling pathway (GO:0060337)4.28352993
20detection of bacterium (GO:0016045)4.27169285
21response to type I interferon (GO:0034340)4.27122493
22neutrophil activation involved in immune response (GO:0002283)4.21186485
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.14215196
24response to peptidoglycan (GO:0032494)4.12463493
25regulation of interferon-beta biosynthetic process (GO:0045357)4.08097327
26detection of molecule of bacterial origin (GO:0032490)4.06143445
27negative regulation of interleukin-12 production (GO:0032695)4.05204780
28positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.00054112
29detection of external biotic stimulus (GO:0098581)3.96554134
30regulation of gamma-delta T cell differentiation (GO:0045586)3.84200072
31negative regulation of lymphocyte mediated immunity (GO:0002707)3.76758546
32cellular extravasation (GO:0045123)3.76170298
33leukocyte aggregation (GO:0070486)3.75671047
34B cell receptor signaling pathway (GO:0050853)3.74299780
35immunoglobulin mediated immune response (GO:0016064)3.73924746
36response to interleukin-15 (GO:0070672)3.68108537
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.63488362
38response to host immune response (GO:0052572)3.63488362
39production of molecular mediator involved in inflammatory response (GO:0002532)3.56918072
40germinal center formation (GO:0002467)3.51895354
41negative regulation of T cell mediated immunity (GO:0002710)3.51412505
42interferon-gamma-mediated signaling pathway (GO:0060333)3.45082855
43cellular response to interleukin-15 (GO:0071350)3.41600211
44microglial cell activation (GO:0001774)3.41007101
45detection of biotic stimulus (GO:0009595)3.39473453
46response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.37828839
47response to host (GO:0075136)3.37828839
48response to host defenses (GO:0052200)3.37828839
49regulation of T cell tolerance induction (GO:0002664)3.32327707
50negative regulation of leukocyte mediated immunity (GO:0002704)3.31026262
51regulation of T-helper 2 cell differentiation (GO:0045628)3.29867733
52macrophage activation (GO:0042116)3.29771265
53defense response to protozoan (GO:0042832)3.28626189
54myeloid cell activation involved in immune response (GO:0002275)3.28268741
55neutrophil activation (GO:0042119)3.27665695
56T cell migration (GO:0072678)3.23818358
57respiratory burst (GO:0045730)3.22153812
58negative thymic T cell selection (GO:0045060)3.20851531
59regulation of tolerance induction (GO:0002643)3.16087412
60regulation of dendritic cell antigen processing and presentation (GO:0002604)3.15408423
61positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.12809571
62negative T cell selection (GO:0043383)3.12650167
63positive regulation of interferon-alpha production (GO:0032727)3.10558499
64positive regulation of type 2 immune response (GO:0002830)3.10537579
65negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.09355915
66positive thymic T cell selection (GO:0045059)3.05711824
67granulocyte activation (GO:0036230)3.05618837
68antigen processing and presentation via MHC class Ib (GO:0002475)3.05176383
69regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.03109823
70regulation of B cell differentiation (GO:0045577)3.02480135
71regulation of interferon-alpha production (GO:0032647)3.01185109
72negative regulation of erythrocyte differentiation (GO:0045647)2.99817876
73T cell selection (GO:0045058)2.97559935
74positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.97546051
75response to protozoan (GO:0001562)2.97469358
76lipopolysaccharide-mediated signaling pathway (GO:0031663)2.96500188
77response to interferon-alpha (GO:0035455)2.96352945
78B cell mediated immunity (GO:0019724)2.95557602
79response to muramyl dipeptide (GO:0032495)2.93622663
80regulation of T cell mediated cytotoxicity (GO:0001914)2.93305037
81positive regulation of B cell differentiation (GO:0045579)2.91198845
82regulation of regulatory T cell differentiation (GO:0045589)2.91183409
83thymic T cell selection (GO:0045061)2.90330288
84positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.88234716
85regulation of mast cell degranulation (GO:0043304)2.87334268
86regulation of necroptotic process (GO:0060544)2.86962686
87negative regulation of T-helper cell differentiation (GO:0045623)2.85750571
88negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.85750571
89positive regulation of T cell mediated cytotoxicity (GO:0001916)2.84157476
90regulation of alpha-beta T cell proliferation (GO:0046640)2.83746751
91neutrophil mediated immunity (GO:0002446)2.81654646
92leukocyte migration involved in inflammatory response (GO:0002523)2.81056322
93regulation of type 2 immune response (GO:0002828)2.81003264
94regulation of antigen processing and presentation (GO:0002577)2.80587585
95dendritic cell chemotaxis (GO:0002407)2.79916083
96positive regulation of tolerance induction (GO:0002645)2.78539657
97NIK/NF-kappaB signaling (GO:0038061)2.77111706
98negative regulation of innate immune response (GO:0045824)2.76596078
99negative regulation of type 2 immune response (GO:0002829)2.76041832
100JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.74378327

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.05106624
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.24617498
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.00227069
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.86046601
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.64982258
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.39635412
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.17746695
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.96405443
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.94221100
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.93947019
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.71385228
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.62442696
13* RUNX_20019798_ChIP-Seq_JUKART_Human2.60208160
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.53847955
15MYB_26560356_Chip-Seq_TH2_Human2.32682358
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.31929317
17MAF_26560356_Chip-Seq_TH1_Human2.31824999
18VDR_21846776_ChIP-Seq_THP-1_Human2.29031669
19* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.27013400
20MYC_22102868_ChIP-Seq_BL_Human2.25318269
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.25174987
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.24314953
23* VDR_24763502_ChIP-Seq_THP-1_Human2.24017399
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.23040961
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.21159035
26* SPI1_23127762_ChIP-Seq_K562_Human2.20941715
27SPI1_23547873_ChIP-Seq_NB4_Human2.20645428
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.18610311
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.14241635
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.10186803
31* MYB_26560356_Chip-Seq_TH1_Human2.04406650
32SMAD_19615063_ChIP-ChIP_OVARY_Human2.01198102
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.98200685
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.95446624
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.94782512
36UTX_26944678_Chip-Seq_JUKART_Human1.94749418
37SCL_19346495_ChIP-Seq_HPC-7_Human1.92162653
38TCF7_22412390_ChIP-Seq_EML_Mouse1.90966391
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.90505457
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.81308220
41MAF_26560356_Chip-Seq_TH2_Human1.73270110
42GATA1_22025678_ChIP-Seq_K562_Human1.72177526
43KDM2B_26808549_Chip-Seq_DND41_Human1.72121373
44KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.64988751
45GATA3_27048872_Chip-Seq_THYMUS_Human1.61478137
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.55924257
47* VDR_24787735_ChIP-Seq_THP-1_Human1.55621469
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.49155361
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.45899929
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40312276
51GATA1_19941827_ChIP-Seq_MEL_Mouse1.39669794
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39209937
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38945456
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35880359
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.31735646
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.29116946
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.27862495
58PU_27001747_Chip-Seq_BMDM_Mouse1.24820287
59LXR_22292898_ChIP-Seq_THP-1_Human1.23373626
60PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22213475
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22186133
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22120442
63GATA3_26560356_Chip-Seq_TH2_Human1.16050572
64CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14550807
65KDM2B_26808549_Chip-Seq_JURKAT_Human1.13900984
66GATA1_19941826_ChIP-Seq_K562_Human1.13853216
67PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13641291
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13003213
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12556747
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11457669
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10128110
72NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06335924
73PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04742658
74SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04547196
75CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04099156
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03842241
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03647312
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03479670
79* RACK7_27058665_Chip-Seq_MCF-7_Human1.03385801
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02531822
81VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01583125
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01504219
83GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01466069
84CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01283129
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00278192
86ESR1_20079471_ChIP-ChIP_T-47D_Human1.00250144
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98769227
88PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96636945
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95519198
90STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93720660
91KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93161341
92GATA2_19941826_ChIP-Seq_K562_Human0.92378728
93ESR2_21235772_ChIP-Seq_MCF-7_Human0.91676173
94* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89283629
95ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.86980985
96PPARA_22158963_ChIP-Seq_LIVER_Mouse0.86249657
97CTCF_27219007_Chip-Seq_ERYTHROID_Human0.85036011
98CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.84378264
99FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.84240035
100BCOR_27268052_Chip-Seq_Bcells_Human0.83126785

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.51984704
2MP0003303_peritoneal_inflammation3.82502616
3MP0001835_abnormal_antigen_presentation3.66887950
4MP0003436_decreased_susceptibility_to3.56778743
5MP0005387_immune_system_phenotype2.98739498
6MP0001790_abnormal_immune_system2.98739498
7MP0009785_altered_susceptibility_to2.93177302
8MP0001800_abnormal_humoral_immune2.92449710
9MP0000685_abnormal_immune_system2.78862069
10MP0005671_abnormal_response_to2.77802863
11MP0005000_abnormal_immune_tolerance2.77613389
12MP0002419_abnormal_innate_immunity2.75789612
13MP0005025_abnormal_response_to2.69813039
14MP0003763_abnormal_thymus_physiology2.58197053
15MP0003300_gastrointestinal_ulcer2.50706714
16MP0002723_abnormal_immune_serum2.48944016
17MP0002452_abnormal_antigen_presenting2.48257625
18MP0002420_abnormal_adaptive_immunity2.38059362
19MP0001819_abnormal_immune_cell2.35858948
20MP0002148_abnormal_hypersensitivity_rea2.31610088
21MP0006082_CNS_inflammation2.31562903
22MP0005451_abnormal_body_composition2.09621946
23MP0003191_abnormal_cellular_cholesterol2.02162953
24MP0002405_respiratory_system_inflammati1.96876770
25MP0001533_abnormal_skeleton_physiology1.93838120
26MP0004947_skin_inflammation1.91101893
27MP0010155_abnormal_intestine_physiology1.88442573
28MP0002398_abnormal_bone_marrow1.83653475
29MP0000716_abnormal_immune_system1.82003494
30MP0002132_abnormal_respiratory_system1.76049593
31MP0001845_abnormal_inflammatory_respons1.75004028
32MP0008260_abnormal_autophagy1.72537054
33MP0003828_pulmonary_edema1.64763530
34MP0009333_abnormal_splenocyte_physiolog1.63177051
35MP0004381_abnormal_hair_follicle1.62823474
36MP0004510_myositis1.55054664
37MP0005464_abnormal_platelet_physiology1.54650695
38MP0002722_abnormal_immune_system1.48775578
39MP0000689_abnormal_spleen_morphology1.48592177
40MP0002166_altered_tumor_susceptibility1.48150791
41MP0002429_abnormal_blood_cell1.42322718
42MP0000858_altered_metastatic_potential1.40576038
43MP0004883_abnormal_blood_vessel1.40426827
44MP0005310_abnormal_salivary_gland1.39840357
45MP0008469_abnormal_protein_level1.39731005
46MP0009278_abnormal_bone_marrow1.38106749
47MP0002998_abnormal_bone_remodeling1.37549070
48MP0000703_abnormal_thymus_morphology1.36998457
49MP0000465_gastrointestinal_hemorrhage1.35407651
50MP0003866_abnormal_defecation1.32360401
51MP0001545_abnormal_hematopoietic_system1.30494723
52MP0005397_hematopoietic_system_phenotyp1.30494723
53MP0003183_abnormal_peptide_metabolism1.27681753
54MP0009764_decreased_sensitivity_to1.27516455
55MP0003172_abnormal_lysosome_physiology1.27361327
56MP0002138_abnormal_hepatobiliary_system1.24440662
57MP0005164_abnormal_response_to1.23792075
58MP0003075_altered_response_to1.21882584
59MP0001853_heart_inflammation1.21524861
60MP0005166_decreased_susceptibility_to1.21296908
61MP0001851_eye_inflammation1.19821891
62MP0008004_abnormal_stomach_pH1.18122027
63MP0002396_abnormal_hematopoietic_system1.12822536
64MP0001873_stomach_inflammation1.12457840
65MP0003453_abnormal_keratinocyte_physiol1.06222794
66MP0002277_abnormal_respiratory_mucosa1.04248825
67MP0003091_abnormal_cell_migration1.03596730
68MP0005058_abnormal_lysosome_morphology1.03480432
69MP0003045_fibrosis1.02063139
70MP0003448_altered_tumor_morphology0.98642740
71MP0000343_altered_response_to0.98031746
72MP0003690_abnormal_glial_cell0.97079819
73MP0002006_tumorigenesis0.91417839
74MP0002933_joint_inflammation0.90211836
75MP0004264_abnormal_extraembryonic_tissu0.89556954
76MP0009840_abnormal_foam_cell0.86180094
77MP0004808_abnormal_hematopoietic_stem0.83566501
78MP0000249_abnormal_blood_vessel0.79105496
79MP0009763_increased_sensitivity_to0.78045154
80MP0005390_skeleton_phenotype0.76783601
81MP0005666_abnormal_adipose_tissue0.75961916
82MP0003656_abnormal_erythrocyte_physiolo0.74797917
83MP0004185_abnormal_adipocyte_glucose0.73282433
84MP0002332_abnormal_exercise_endurance0.71671185
85MP0010234_abnormal_vibrissa_follicle0.71324428
86MP0003806_abnormal_nucleotide_metabolis0.70681746
87MP0009115_abnormal_fat_cell0.69736309
88MP0001663_abnormal_digestive_system0.69632406
89MP0003795_abnormal_bone_structure0.68775765
90MP0003566_abnormal_cell_adhesion0.67543188
91MP0000490_abnormal_crypts_of0.65687896
92MP0000604_amyloidosis0.64689228
93MP0003221_abnormal_cardiomyocyte_apopto0.64369102
94MP0008874_decreased_physiological_sensi0.63794318
95MP0001849_ear_inflammation0.59999904
96MP0005075_abnormal_melanosome_morpholog0.59105933
97MP0005076_abnormal_cell_differentiation0.59100630
98MP0004484_altered_response_of0.56864301
99MP0005023_abnormal_wound_healing0.56495876
100MP0002009_preneoplasia0.55836172

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.99076274
2Recurrent bacterial skin infections (HP:0005406)5.22940211
3Recurrent abscess formation (HP:0002722)5.11529522
4Myositis (HP:0100614)5.00499138
5Orchitis (HP:0100796)4.92434443
6Retrobulbar optic neuritis (HP:0100654)4.70579512
7Optic neuritis (HP:0100653)4.70579512
8Abnormality of macrophages (HP:0004311)4.66651850
9Recurrent gram-negative bacterial infections (HP:0005420)4.10802596
10Mediastinal lymphadenopathy (HP:0100721)3.92091010
11Gastrointestinal infarctions (HP:0005244)3.89452356
12Recurrent fungal infections (HP:0002841)3.85061170
13Meningitis (HP:0001287)3.82444751
14Stomatitis (HP:0010280)3.78079655
15Elevated erythrocyte sedimentation rate (HP:0003565)3.77621054
16Vasculitis (HP:0002633)3.66620979
17Keratoconjunctivitis sicca (HP:0001097)3.65491714
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.53617214
19T lymphocytopenia (HP:0005403)3.47352513
20Recurrent skin infections (HP:0001581)3.47012196
21Spontaneous hematomas (HP:0007420)3.44458192
22Chronic obstructive pulmonary disease (HP:0006510)3.40460708
23Obstructive lung disease (HP:0006536)3.40460708
24Gingivitis (HP:0000230)3.39379153
25Increased IgE level (HP:0003212)3.36122321
26Abnormality of T cell number (HP:0011839)3.31758433
27Keratoconjunctivitis (HP:0001096)3.31546749
28Recurrent viral infections (HP:0004429)3.26496469
29Cellulitis (HP:0100658)3.23983435
30Colitis (HP:0002583)3.20480557
31Encephalitis (HP:0002383)3.18465338
32Inflammation of the large intestine (HP:0002037)3.17300789
33Recurrent cutaneous fungal infections (HP:0011370)3.12337052
34Chronic mucocutaneous candidiasis (HP:0002728)3.12337052
35Gastrointestinal inflammation (HP:0004386)3.06282964
36Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.98546339
37Urticaria (HP:0001025)2.92583273
38Pulmonary infiltrates (HP:0002113)2.88900161
39Hemoptysis (HP:0002105)2.85038624
40Chest pain (HP:0100749)2.77180791
41Prolonged bleeding time (HP:0003010)2.75892067
42Recurrent bronchitis (HP:0002837)2.73779683
43Abnormality of T cells (HP:0002843)2.69369501
44Arterial thrombosis (HP:0004420)2.67443052
45Granulocytopenia (HP:0001913)2.63463905
46Osteomyelitis (HP:0002754)2.63145164
47Gastrointestinal stroma tumor (HP:0100723)2.62356077
48Leukocytosis (HP:0001974)2.60005796
49Panhypogammaglobulinemia (HP:0003139)2.55888191
50Gingival bleeding (HP:0000225)2.52864450
51Pustule (HP:0200039)2.52531477
52Lymphopenia (HP:0001888)2.49990818
53Agammaglobulinemia (HP:0004432)2.47335164
54Pulmonary embolism (HP:0002204)2.45420500
55Increased IgM level (HP:0003496)2.44777314
56Anorexia (HP:0002039)2.40170830
57Autoimmune hemolytic anemia (HP:0001890)2.39514521
58Hypochromic microcytic anemia (HP:0004840)2.39188801
59Hypochromic anemia (HP:0001931)2.39158677
60Abnormality of cells of the lymphoid lineage (HP:0012140)2.39133192
61Interstitial pulmonary disease (HP:0006530)2.38298062
62Epistaxis (HP:0000421)2.38128886
63Eosinophilia (HP:0001880)2.37296769
64Papilledema (HP:0001085)2.30371113
65Gangrene (HP:0100758)2.28757097
66Sepsis (HP:0100806)2.26324438
67Hypergammaglobulinemia (HP:0010702)2.18082867
68IgM deficiency (HP:0002850)2.17584062
69Skin ulcer (HP:0200042)2.16235449
70Abnormality of T cell physiology (HP:0011840)2.15735439
71Abnormality of the pleura (HP:0002103)2.15453951
72Acute hepatic failure (HP:0006554)2.14768959
73Episodic fever (HP:0001954)2.13736542
74Amyloidosis (HP:0011034)2.13413524
75Peritonitis (HP:0002586)2.12895171
76Premature loss of primary teeth (HP:0006323)2.11071658
77Papilloma (HP:0012740)2.09720551
78Verrucae (HP:0200043)2.09720551
79Slow saccadic eye movements (HP:0000514)2.08736264
80Nasal polyposis (HP:0100582)2.05818732
81Chronic otitis media (HP:0000389)2.05185297
82Viral hepatitis (HP:0006562)2.00807958
83Restrictive lung disease (HP:0002091)2.00073048
84Recurrent sinusitis (HP:0011108)1.98738911
85Abnormality of the endocardium (HP:0004306)1.98647605
86Petechiae (HP:0000967)1.98431470
87Abnormality of the peritoneum (HP:0002585)1.98366060
88Joint swelling (HP:0001386)1.95568268
89Glomerulopathy (HP:0100820)1.93664465
90Abnormality of the nasal mucosa (HP:0000433)1.93289809
91Microcytic anemia (HP:0001935)1.89572721
92Loss of speech (HP:0002371)1.89384905
93Systemic lupus erythematosus (HP:0002725)1.89355075
94Skin rash (HP:0000988)1.89178094
95Polyneuropathy (HP:0001271)1.89145123
96Autoimmune thrombocytopenia (HP:0001973)1.89143429
97Purpura (HP:0000979)1.88946235
98Abnormality of glycolipid metabolism (HP:0010969)1.88784034
99Abnormality of liposaccharide metabolism (HP:0010968)1.88784034
100Abnormality of glycosphingolipid metabolism (HP:0004343)1.88784034

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.39047532
2MAP4K13.83677952
3ERN13.19436675
4BLK3.07383933
5IRAK42.91789998
6TYK22.90314740
7PRPF4B2.72572404
8CSK2.52208847
9MAP2K32.25822918
10EPHB12.15154623
11ZAP702.02752673
12JAK31.98133766
13MAP3K141.91214540
14BTK1.89667956
15MAP3K131.85536336
16IKBKE1.85098378
17FES1.83453259
18GRK61.77819601
19JAK11.74104203
20MAP3K31.69641936
21TXK1.63537285
22TNK21.62420650
23TAOK11.51313463
24SYK1.50980684
25MAP3K11.50599735
26HCK1.49765297
27FGFR41.48804255
28TBK11.46778536
29TRIB31.45263921
30MARK31.42701634
31FGR1.42386208
32JAK21.33086072
33SIK31.24535904
34LYN1.18111799
35FGFR31.17452661
36KSR21.16156629
37NLK1.13141856
38ITK1.11073954
39LCK1.05867077
40MAP3K111.03979123
41BMPR21.02949708
42YES11.02347151
43CSF1R1.01815789
44IRAK11.01209896
45RIPK11.00489394
46TGFBR20.95305531
47IKBKB0.94298328
48SIK10.94274344
49STK100.94162066
50MARK20.93723643
51LRRK20.90680545
52CDC42BPA0.89404430
53IRAK20.88719558
54MAP3K20.86812781
55PDK10.85306715
56TAOK30.83713148
57MATK0.83645967
58CDK120.81511773
59KIT0.81047947
60PDPK10.80813339
61TAOK20.80352297
62MAP3K100.79449541
63TEC0.77063489
64HIPK20.75374212
65EPHA30.74449146
66PIK3CG0.74188651
67SMG10.70419925
68MAPK120.69988713
69PTK60.67006174
70SGK30.65623988
71MAP3K60.62983481
72NME20.62797354
73PRKD20.62216385
74PRKCQ0.58186511
75IRAK30.55445533
76STK380.53001441
77SGK20.52789177
78MAPK70.52714251
79MAP3K70.51989910
80RET0.50369150
81FYN0.47602717
82MAP3K50.46787844
83RPS6KL10.45550285
84RPS6KC10.45550285
85MAPKAPK20.42907616
86PIM10.42201017
87GRK70.41786527
88SIK20.41506821
89CDK40.40968490
90MOS0.39229514
91CHUK0.38218340
92PTK2B0.37963428
93PKN20.37314299
94MAPK110.36699018
95PDGFRB0.35514443
96RPS6KA60.34182885
97MAP2K60.32218691
98MST1R0.31312962
99DYRK1B0.31226858
100MELK0.29441671

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.77868365
2Osteoclast differentiation_Homo sapiens_hsa043802.71384574
3Allograft rejection_Homo sapiens_hsa053302.61440770
4Staphylococcus aureus infection_Homo sapiens_hsa051502.53575022
5Graft-versus-host disease_Homo sapiens_hsa053322.51074948
6B cell receptor signaling pathway_Homo sapiens_hsa046622.50388452
7Autoimmune thyroid disease_Homo sapiens_hsa053202.43708381
8Primary immunodeficiency_Homo sapiens_hsa053402.17889764
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.16758953
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.09345177
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.01964356
12Tuberculosis_Homo sapiens_hsa051521.99315745
13Measles_Homo sapiens_hsa051621.98058259
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.97197353
15Type I diabetes mellitus_Homo sapiens_hsa049401.87821227
16Malaria_Homo sapiens_hsa051441.86005431
17Acute myeloid leukemia_Homo sapiens_hsa052211.77727153
18Influenza A_Homo sapiens_hsa051641.77386118
19T cell receptor signaling pathway_Homo sapiens_hsa046601.75033215
20Toxoplasmosis_Homo sapiens_hsa051451.72200104
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.70761578
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.64806388
23Antigen processing and presentation_Homo sapiens_hsa046121.64573135
24Hematopoietic cell lineage_Homo sapiens_hsa046401.62537500
25Viral myocarditis_Homo sapiens_hsa054161.62384048
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.60744875
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.58671188
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.53811347
29Herpes simplex infection_Homo sapiens_hsa051681.52770982
30Chemokine signaling pathway_Homo sapiens_hsa040621.52551759
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.49587418
32Asthma_Homo sapiens_hsa053101.48614925
33TNF signaling pathway_Homo sapiens_hsa046681.46389964
34Hepatitis C_Homo sapiens_hsa051601.35460653
35Legionellosis_Homo sapiens_hsa051341.34010733
36Hepatitis B_Homo sapiens_hsa051611.28355260
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28172982
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28101664
39Non-small cell lung cancer_Homo sapiens_hsa052231.24562338
40African trypanosomiasis_Homo sapiens_hsa051431.16964069
41Phagosome_Homo sapiens_hsa041451.15995006
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.13893404
43Pertussis_Homo sapiens_hsa051331.13138945
44Other glycan degradation_Homo sapiens_hsa005111.08258865
45Pancreatic cancer_Homo sapiens_hsa052121.04548173
46Apoptosis_Homo sapiens_hsa042101.03319988
47Chronic myeloid leukemia_Homo sapiens_hsa052201.00170185
48Rheumatoid arthritis_Homo sapiens_hsa053230.97946951
49VEGF signaling pathway_Homo sapiens_hsa043700.96930444
50Prolactin signaling pathway_Homo sapiens_hsa049170.95652101
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95534736
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94774664
53Platelet activation_Homo sapiens_hsa046110.94321124
54Renal cell carcinoma_Homo sapiens_hsa052110.91527437
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90877612
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88222821
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.78704113
58FoxO signaling pathway_Homo sapiens_hsa040680.78009206
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77401490
60Endometrial cancer_Homo sapiens_hsa052130.77228660
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.74185724
62Salmonella infection_Homo sapiens_hsa051320.72658716
63Shigellosis_Homo sapiens_hsa051310.72455823
64Insulin resistance_Homo sapiens_hsa049310.72006614
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72003472
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.71593084
67Dorso-ventral axis formation_Homo sapiens_hsa043200.69544604
68Notch signaling pathway_Homo sapiens_hsa043300.69375924
69Epstein-Barr virus infection_Homo sapiens_hsa051690.68732640
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68508117
71HTLV-I infection_Homo sapiens_hsa051660.64154637
72Viral carcinogenesis_Homo sapiens_hsa052030.63701288
73Endocytosis_Homo sapiens_hsa041440.63641730
74Amoebiasis_Homo sapiens_hsa051460.62992892
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62606971
76Prostate cancer_Homo sapiens_hsa052150.59933565
77Lysosome_Homo sapiens_hsa041420.59809998
78mTOR signaling pathway_Homo sapiens_hsa041500.58052850
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.55025070
80Type II diabetes mellitus_Homo sapiens_hsa049300.53655806
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53155909
82HIF-1 signaling pathway_Homo sapiens_hsa040660.51335488
83Choline metabolism in cancer_Homo sapiens_hsa052310.50266289
84Inositol phosphate metabolism_Homo sapiens_hsa005620.50233235
85Insulin signaling pathway_Homo sapiens_hsa049100.48917177
86Thyroid cancer_Homo sapiens_hsa052160.48747930
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48734550
88GnRH signaling pathway_Homo sapiens_hsa049120.47536015
89ErbB signaling pathway_Homo sapiens_hsa040120.44448314
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44024631
91Colorectal cancer_Homo sapiens_hsa052100.43585559
92Small cell lung cancer_Homo sapiens_hsa052220.42121513
93Glioma_Homo sapiens_hsa052140.41800070
94MAPK signaling pathway_Homo sapiens_hsa040100.40405740
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.36844920
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36696479
97Estrogen signaling pathway_Homo sapiens_hsa049150.34907741
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34068316
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.33485287
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31429853

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