ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	seminiferous tubule development (GO:0072520)	5.62946580
2	negative regulation of B cell apoptotic process (GO:0002903)	5.61235935
3	purine deoxyribonucleotide catabolic process (GO:0009155)	5.43542863
4	purine nucleotide salvage (GO:0032261)	5.11984495
5	deoxyribonucleotide catabolic process (GO:0009264)	4.94124627
6	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.91436514
7	aggressive behavior (GO:0002118)	4.86059801
8	positive regulation of B cell differentiation (GO:0045579)	4.84840675
9	Peyers patch development (GO:0048541)	4.84195917
10	mucosal-associated lymphoid tissue development (GO:0048537)	4.84195917
11	deoxyribose phosphate catabolic process (GO:0046386)	4.81016732
12	mature B cell differentiation involved in immune response (GO:0002313)	4.74292212
13	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	4.66416832
14	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.53236402
15	regulation of B cell apoptotic process (GO:0002902)	4.50800232
16	immunoglobulin mediated immune response (GO:0016064)	4.27868767
17	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	4.06371444
18	definitive hemopoiesis (GO:0060216)	4.05559366
19	purine deoxyribonucleotide metabolic process (GO:0009151)	4.01900752
20	base-excision repair, AP site formation (GO:0006285)	4.01686598
21	nucleotide salvage (GO:0043173)	3.98836403
22	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	3.96363342
23	pyrimidine nucleotide catabolic process (GO:0006244)	3.94937777
24	regulation of germinal center formation (GO:0002634)	3.87513623
25	B cell mediated immunity (GO:0019724)	3.86941025
26	ribosomal small subunit assembly (GO:0000028)	3.78310037
27	histamine secretion (GO:0001821)	3.78136445
28	autophagic vacuole fusion (GO:0000046)	3.77325785
29	positive regulation of antigen processing and presentation (GO:0002579)	3.76263475
30	negative regulation of thymocyte apoptotic process (GO:0070244)	3.69238677
31	regulation of penile erection (GO:0060405)	3.68125142
32	2-deoxyribonucleotide metabolic process (GO:0009394)	3.66408707
33	endothelium development (GO:0003158)	3.65213286
34	regulation of antigen processing and presentation (GO:0002577)	3.53983016
35	deoxyribose phosphate metabolic process (GO:0019692)	3.52961049
36	response to interferon-beta (GO:0035456)	3.50126869
37	purine-containing compound salvage (GO:0043101)	3.48039875
38	positive thymic T cell selection (GO:0045059)	3.47511127
39	regulation of female receptivity (GO:0045924)	3.43747052
40	mature B cell differentiation (GO:0002335)	3.43483290
41	regulation of dendritic cell antigen processing and presentation (GO:0002604)	3.43450107
42	DNA deamination (GO:0045006)	3.41870704
43	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	3.41440717
44	regulation of B cell differentiation (GO:0045577)	3.33969198
45	female mating behavior (GO:0060180)	3.33767849
46	regulation of T-helper 1 cell differentiation (GO:0045625)	3.30067433
47	antigen processing and presentation of endogenous antigen (GO:0019883)	3.27512885
48	cellular response to exogenous dsRNA (GO:0071360)	3.26660794
49	chaperone mediated protein folding requiring cofactor (GO:0051085)	3.23106256
50	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.22726190
51	positive regulation of T cell differentiation in thymus (GO:0033089)	3.17850319
52	B cell receptor signaling pathway (GO:0050853)	3.13011691
53	positive regulation of prostaglandin secretion (GO:0032308)	3.06453400
54	deoxyribonucleotide metabolic process (GO:0009262)	3.01410308
55	positive regulation of gamma-delta T cell activation (GO:0046645)	2.99516516
56	grooming behavior (GO:0007625)	2.98039256
57	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.95289583
58	negative regulation of T-helper cell differentiation (GO:0045623)	2.95289583
59	protein complex biogenesis (GO:0070271)	2.94844424
60	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.93285164
61	histamine transport (GO:0051608)	2.90240200
62	positive regulation of granulocyte differentiation (GO:0030854)	2.89999819
63	organelle membrane fusion (GO:0090174)	2.88403803
64	negative regulation of erythrocyte differentiation (GO:0045647)	2.87666958
65	negative thymic T cell selection (GO:0045060)	2.81617393
66	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.78865499
67	cellular response to interferon-beta (GO:0035458)	2.77798588
68	thrombin receptor signaling pathway (GO:0070493)	2.73758063
69	UV protection (GO:0009650)	2.73694401
70	regulation of thymocyte apoptotic process (GO:0070243)	2.71994670
71	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	2.71369349
72	adenosine metabolic process (GO:0046085)	2.71254765
73	mitochondrial respiratory chain complex assembly (GO:0033108)	2.70917081
74	hyperosmotic salinity response (GO:0042538)	2.69430252
75	regulation of B cell receptor signaling pathway (GO:0050855)	2.69018676
76	mast cell degranulation (GO:0043303)	2.68296728
77	mast cell activation involved in immune response (GO:0002279)	2.68296728
78	iron-sulfur cluster assembly (GO:0016226)	2.66307951
79	metallo-sulfur cluster assembly (GO:0031163)	2.66307951
80	response to vitamin E (GO:0033197)	2.66292513
81	negative regulation of nitric oxide biosynthetic process (GO:0045019)	2.59050282
82	cellular hyperosmotic response (GO:0071474)	2.58117202
83	epithelial cell differentiation involved in kidney development (GO:0035850)	2.57982697
84	pseudouridine synthesis (GO:0001522)	2.56633502
85	negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)	2.55638856
86	negative T cell selection (GO:0043383)	2.51884394
87	negative regulation of T cell apoptotic process (GO:0070233)	2.50872705
88	viral transcription (GO:0019083)	2.49721333
89	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	2.49212990
90	ubiquinone biosynthetic process (GO:0006744)	2.48316494
91	positive regulation of B cell activation (GO:0050871)	2.47740789
92	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.47673959
93	NADH dehydrogenase complex assembly (GO:0010257)	2.47673959
94	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.47673959
95	positive regulation of neutrophil migration (GO:1902624)	2.45208410
96	positive regulation of neutrophil chemotaxis (GO:0090023)	2.45208410
97	cytochrome complex assembly (GO:0017004)	2.43948323
98	response to host immune response (GO:0052572)	2.41287581
99	response to immune response of other organism involved in symbiotic interaction (GO:0052564)	2.41287581
100	translational termination (GO:0006415)	2.40189243

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IRF8_22096565_ChIP-ChIP_GC-B_Human	6.27908995
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	5.54063621
3	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.13277913
4	SCL_19346495_ChIP-Seq_HPC-7_Human	3.70539897
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.75246550
6	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	2.74077882
7	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	2.63627451
8	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.61856218
9	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	2.41715897
10	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	2.33273925
11	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.32633085
12	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	2.30321209
13	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	2.24597423
14	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.23237266
15	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.20735080
16	MYB_26560356_Chip-Seq_TH2_Human	2.12691020
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.12069419
18	VDR_21846776_ChIP-Seq_THP-1_Human	2.11903291
19	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	2.09779517
20	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.08345116
21	CIITA_25753668_ChIP-Seq_RAJI_Human	2.07127617
22	SPI1_23547873_ChIP-Seq_NB4_Human	2.06710952
23	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.04639833
24	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	2.01942768
25	FOXP3_21729870_ChIP-Seq_TREG_Human	1.97347172
26	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.95070346
27	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.89334886
28	VDR_23849224_ChIP-Seq_CD4+_Human	1.88339828
29	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.88039833
30	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.83644982
31	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.77665228
32	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.77151597
33	VDR_24763502_ChIP-Seq_THP-1_Human	1.76048986
34	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.74121423
35	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.73857863
36	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.67979262
37	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.66454206
38	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.65925246
39	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.64411600
40	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.63888404
41	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.63735188
42	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.61633284
43	BCL6_27268052_Chip-Seq_Bcells_Human	1.61314263
44	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.59495137
45	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.59411016
46	UTX_26944678_Chip-Seq_JUKART_Human	1.59076542
47	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.57373253
48	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.56231213
49	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.56087704
50	MYC_22102868_ChIP-Seq_BL_Human	1.50026235
51	MYB_26560356_Chip-Seq_TH1_Human	1.44265886
52	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.42224022
53	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.39881060
54	GATA2_22383799_ChIP-Seq_G1ME_Mouse	1.38340772
55	GATA3_27048872_Chip-Seq_THYMUS_Human	1.36825796
56	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.34277615
57	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.33703051
58	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.33654515
59	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.33311897
60	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.30962631
61	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.30808254
62	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.28064795
63	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.27430884
64	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.26390469
65	MAF_26560356_Chip-Seq_TH1_Human	1.23868321
66	RUNX_20019798_ChIP-Seq_JUKART_Human	1.23826800
67	BCOR_27268052_Chip-Seq_Bcells_Human	1.21311662
68	ZNF274_21170338_ChIP-Seq_K562_Hela	1.21036203
69	P300_27268052_Chip-Seq_Bcells_Human	1.20021232
70	SPI1_20517297_ChIP-Seq_HL60_Human	1.19957622
71	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.19236555
72	SPI1_23127762_ChIP-Seq_K562_Human	1.17720932
73	GATA3_26560356_Chip-Seq_TH2_Human	1.17209051
74	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.15533466
75	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.14199834
76	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.13856532
77	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.13223261
78	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.12885726
79	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.10696849
80	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.09159490
81	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.07367290
82	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.05654926
83	STAT1_20625510_ChIP-Seq_HELA_Human	1.04247864
84	E2F1_20622854_ChIP-Seq_HELA_Human	1.03767390
85	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.03517597
86	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.02018583
87	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.01584789
88	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.01425626
89	E2F7_22180533_ChIP-Seq_HELA_Human	1.01326494
90	GATA1_19941826_ChIP-Seq_K562_Human	1.00171270
91	MYC_18940864_ChIP-ChIP_HL60_Human	1.00028109
92	GATA1_22025678_ChIP-Seq_K562_Human	0.99430865
93	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.99392201
94	GABP_19822575_ChIP-Seq_HepG2_Human	0.98768320
95	P68_20966046_ChIP-Seq_HELA_Human	0.98197023
96	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.98112158
97	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.97540590
98	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.94780954
99	CTCF_21964334_ChIP-Seq_BJAB-B_Human	0.94675083
100	RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.94360326

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009278_abnormal_bone_marrow	3.79470806
2	MP0001835_abnormal_antigen_presentation	3.74980529
3	MP0005397_hematopoietic_system_phenotyp	3.35885680
4	MP0001545_abnormal_hematopoietic_system	3.35885680
5	MP0003806_abnormal_nucleotide_metabolis	3.26515236
6	MP0002396_abnormal_hematopoietic_system	3.22645929
7	MP0005464_abnormal_platelet_physiology	3.17541305
8	MP0009697_abnormal_copulation	3.11962129
9	MP0005084_abnormal_gallbladder_morpholo	2.66123508
10	MP0002148_abnormal_hypersensitivity_rea	2.65536363
11	MP0000465_gastrointestinal_hemorrhage	2.61461506
12	MP0002132_abnormal_respiratory_system	2.14963218
13	MP0003724_increased_susceptibility_to	2.09916341
14	MP0005000_abnormal_immune_tolerance	2.09278607
15	MP0008058_abnormal_DNA_repair	2.01280493
16	MP0005075_abnormal_melanosome_morpholog	2.00486052
17	MP0004808_abnormal_hematopoietic_stem	1.98953544
18	MP0005645_abnormal_hypothalamus_physiol	1.98645205
19	MP0003436_decreased_susceptibility_to	1.96333062
20	MP0001800_abnormal_humoral_immune	1.96192252
21	MP0002398_abnormal_bone_marrow	1.85352012
22	MP0005646_abnormal_pituitary_gland	1.84801634
23	MP0002723_abnormal_immune_serum	1.80088742
24	MP0002420_abnormal_adaptive_immunity	1.80028051
25	MP0002452_abnormal_antigen_presenting	1.79496409
26	MP0005025_abnormal_response_to	1.78309844
27	MP0001819_abnormal_immune_cell	1.77305050
28	MP0006036_abnormal_mitochondrial_physio	1.74164282
29	MP0003763_abnormal_thymus_physiology	1.71325488
30	MP0003191_abnormal_cellular_cholesterol	1.69131988
31	MP0000689_abnormal_spleen_morphology	1.69078145
32	MP0005387_immune_system_phenotype	1.67567454
33	MP0001790_abnormal_immune_system	1.67567454
34	MP0006292_abnormal_olfactory_placode	1.64821941
35	MP0009379_abnormal_foot_pigmentation	1.58535046
36	MP0000716_abnormal_immune_system	1.56478106
37	MP0002722_abnormal_immune_system	1.53370378
38	MP0002419_abnormal_innate_immunity	1.53019140
39	MP0000685_abnormal_immune_system	1.51199805
40	MP0000681_abnormal_thyroid_gland	1.51116784
41	MP0000372_irregular_coat_pigmentation	1.49678144
42	MP0002429_abnormal_blood_cell	1.45960585
43	MP0003787_abnormal_imprinting	1.43932475
44	MP0003718_maternal_effect	1.39008979
45	MP0008872_abnormal_physiological_respon	1.36474155
46	MP0003252_abnormal_bile_duct	1.33648039
47	MP0003866_abnormal_defecation	1.33573031
48	MP0002019_abnormal_tumor_incidence	1.33097739
49	MP0009785_altered_susceptibility_to	1.29727530
50	MP0005671_abnormal_response_to	1.24225538
51	MP0002405_respiratory_system_inflammati	1.24217205
52	MP0001764_abnormal_homeostasis	1.22299833
53	MP0001986_abnormal_taste_sensitivity	1.18481519
54	MP0010155_abnormal_intestine_physiology	1.18344842
55	MP0010094_abnormal_chromosome_stability	1.16369055
56	MP0002006_tumorigenesis	1.14794033
57	MP0009333_abnormal_splenocyte_physiolog	1.12523566
58	MP0003303_peritoneal_inflammation	1.10875397
59	MP0002166_altered_tumor_susceptibility	1.09959674
60	MP0005220_abnormal_exocrine_pancreas	1.08885532
61	MP0008469_abnormal_protein_level	1.08552187
62	MP0004147_increased_porphyrin_level	1.08407593
63	MP0009764_decreased_sensitivity_to	1.06607346
64	MP0001968_abnormal_touch/_nociception	1.06567922
65	MP0001905_abnormal_dopamine_level	1.06353350
66	MP0002653_abnormal_ependyma_morphology	1.05335024
67	MP0005410_abnormal_fertilization	1.04686549
68	MP0001845_abnormal_inflammatory_respons	1.01599662
69	MP0008875_abnormal_xenobiotic_pharmacok	1.00733997
70	MP0000703_abnormal_thymus_morphology	1.00117132
71	MP0002822_catalepsy	0.99542731
72	MP0006035_abnormal_mitochondrial_morpho	0.98192786
73	MP0008007_abnormal_cellular_replicative	0.92661449
74	MP0000230_abnormal_systemic_arterial	0.86505128
75	MP0003075_altered_response_to	0.84511251
76	MP0003186_abnormal_redox_activity	0.83015235
77	MP0003786_premature_aging	0.82398330
78	MP0001533_abnormal_skeleton_physiology	0.81879255
79	MP0003183_abnormal_peptide_metabolism	0.81452856
80	MP0005535_abnormal_body_temperature	0.80419632
81	MP0003943_abnormal_hepatobiliary_system	0.78904852
82	MP0008877_abnormal_DNA_methylation	0.77850335
83	MP0001873_stomach_inflammation	0.77745005
84	MP0009765_abnormal_xenobiotic_induced	0.76379231
85	MP0004782_abnormal_surfactant_physiolog	0.76245888
86	MP0005670_abnormal_white_adipose	0.73760660
87	MP0009763_increased_sensitivity_to	0.72495582
88	MP0001881_abnormal_mammary_gland	0.71284327
89	MP0001853_heart_inflammation	0.68987081
90	MP0002735_abnormal_chemical_nociception	0.68626066
91	MP0005319_abnormal_enzyme/_coenzyme	0.68330515
92	MP0003656_abnormal_erythrocyte_physiolo	0.68195722
93	MP0005165_increased_susceptibility_to	0.67652149
94	MP0008995_early_reproductive_senescence	0.67577273
95	MP0000013_abnormal_adipose_tissue	0.67479958
96	MP0008873_increased_physiological_sensi	0.67049568
97	MP0000678_abnormal_parathyroid_gland	0.66078758
98	MP0006276_abnormal_autonomic_nervous	0.64486025
99	MP0008004_abnormal_stomach_pH	0.64122774
100	MP0001664_abnormal_digestion	0.63775505

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Agammaglobulinemia (HP:0004432)	6.08465312
2	Abnormality of B cell number (HP:0010975)	5.53158433
3	B lymphocytopenia (HP:0010976)	5.33911941
4	Panhypogammaglobulinemia (HP:0003139)	4.99472133
5	Elevated erythrocyte sedimentation rate (HP:0003565)	4.39317113
6	Severe combined immunodeficiency (HP:0004430)	4.28596346
7	Autoimmune hemolytic anemia (HP:0001890)	3.83541306
8	Autoimmune thrombocytopenia (HP:0001973)	3.70525450
9	Type I transferrin isoform profile (HP:0003642)	3.52768974
10	Increased IgE level (HP:0003212)	3.52579826
11	Thrombocytosis (HP:0001894)	3.45449655
12	Prolonged bleeding time (HP:0003010)	3.35192921
13	Increased intramyocellular lipid droplets (HP:0012240)	3.33895412
14	Combined immunodeficiency (HP:0005387)	3.31044244
15	Acute lymphatic leukemia (HP:0006721)	3.24329648
16	Increased muscle lipid content (HP:0009058)	3.18850384
17	Microvesicular hepatic steatosis (HP:0001414)	3.16657356
18	Hepatocellular necrosis (HP:0001404)	3.11898381
19	Cerebral palsy (HP:0100021)	3.04373194
20	Dicarboxylic aciduria (HP:0003215)	3.04209006
21	Abnormality of dicarboxylic acid metabolism (HP:0010995)	3.04209006
22	Recurrent fungal infections (HP:0002841)	3.02679626
23	Recurrent viral infections (HP:0004429)	3.01273801
24	Thyroiditis (HP:0100646)	2.97292397
25	Aplastic anemia (HP:0001915)	2.96076719
26	Reduced antithrombin III activity (HP:0001976)	2.95680501
27	Meningitis (HP:0001287)	2.95206365
28	Granulocytopenia (HP:0001913)	2.93203520
29	Myositis (HP:0100614)	2.91700759
30	Stomatitis (HP:0010280)	2.87759812
31	Abnormality of the prostate (HP:0008775)	2.87180197
32	Hepatic necrosis (HP:0002605)	2.84890009
33	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.79177611
34	Abnormal protein N-linked glycosylation (HP:0012347)	2.79177611
35	Abnormal protein glycosylation (HP:0012346)	2.79177611
36	Abnormal glycosylation (HP:0012345)	2.79177611
37	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.79073967
38	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.74765405
39	Cellulitis (HP:0100658)	2.74340246
40	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.72479630
41	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.72479630
42	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.71347875
43	Mitochondrial inheritance (HP:0001427)	2.66887802
44	Petechiae (HP:0000967)	2.57350435
45	Mesangial abnormality (HP:0001966)	2.56169539
46	Epistaxis (HP:0000421)	2.55507580
47	Abnormal mitochondria in muscle tissue (HP:0008316)	2.50799174
48	Chronic obstructive pulmonary disease (HP:0006510)	2.50669380
49	Obstructive lung disease (HP:0006536)	2.50669380
50	Eosinophilia (HP:0001880)	2.49435164
51	Mediastinal lymphadenopathy (HP:0100721)	2.43277764
52	Chronic otitis media (HP:0000389)	2.42528832
53	Ragged-red muscle fibers (HP:0003200)	2.40553878
54	Aplasia/Hypoplasia of the thymus (HP:0010515)	2.40029283
55	Encephalitis (HP:0002383)	2.39266348
56	Hypergammaglobulinemia (HP:0010702)	2.29426144
57	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.25030740
58	3-Methylglutaconic aciduria (HP:0003535)	2.24678006
59	Abnormality of T cell physiology (HP:0011840)	2.22791913
60	Sepsis (HP:0100806)	2.20652786
61	Increased CSF lactate (HP:0002490)	2.20427729
62	IgG deficiency (HP:0004315)	2.18524852
63	Abnormal number of erythroid precursors (HP:0012131)	2.10197698
64	Stomach cancer (HP:0012126)	2.08492508
65	Decreased central vision (HP:0007663)	2.08383507
66	Abnormality of eosinophils (HP:0001879)	2.08202680
67	Abnormality of T cells (HP:0002843)	2.03565614
68	Gastrointestinal inflammation (HP:0004386)	2.01154042
69	Prostate neoplasm (HP:0100787)	1.99740565
70	Attenuation of retinal blood vessels (HP:0007843)	1.97278919
71	Gingival bleeding (HP:0000225)	1.96186458
72	Leukocytosis (HP:0001974)	1.95398190
73	Rhabdomyolysis (HP:0003201)	1.94848249
74	Ketosis (HP:0001946)	1.94137660
75	Lactic acidosis (HP:0003128)	1.93580321
76	Abnormality of cells of the erythroid lineage (HP:0012130)	1.92953202
77	Skin rash (HP:0000988)	1.92733228
78	Acute hepatic failure (HP:0006554)	1.91968149
79	Hypertensive crisis (HP:0100735)	1.91919108
80	Increased IgM level (HP:0003496)	1.91673106
81	Visual hallucinations (HP:0002367)	1.91242863
82	Chronic mucocutaneous candidiasis (HP:0002728)	1.91117092
83	Recurrent cutaneous fungal infections (HP:0011370)	1.91117092
84	Acute necrotizing encephalopathy (HP:0006965)	1.89214897
85	Papilloma (HP:0012740)	1.88833245
86	Verrucae (HP:0200043)	1.88833245
87	Pancytopenia (HP:0001876)	1.88811899
88	Abolished electroretinogram (ERG) (HP:0000550)	1.88322170
89	Increased serum lactate (HP:0002151)	1.85627161
90	Urticaria (HP:0001025)	1.84013320
91	Dyschromatopsia (HP:0007641)	1.83622048
92	Abnormality of male internal genitalia (HP:0000022)	1.83429811
93	Inflammation of the large intestine (HP:0002037)	1.82788572
94	Recurrent abscess formation (HP:0002722)	1.82132264
95	Failure to thrive in infancy (HP:0001531)	1.81905553
96	Hypoplasia of the thymus (HP:0000778)	1.81751988
97	Progressive microcephaly (HP:0000253)	1.80036243
98	Colitis (HP:0002583)	1.77759629
99	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.76566677
100	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.76176347

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	5.10308314
2	VRK2	4.30902612
3	KIT	3.87808327
4	TAOK3	3.71058987
5	NME2	3.67978331
6	FLT3	2.97924005
7	KDR	2.76535830
8	MAP4K1	2.68149092
9	NUAK1	2.65399498
10	TESK2	2.43557235
11	SCYL2	2.19238167
12	TEC	2.10489862
13	TBK1	2.02569167
14	CSF1R	1.97263920
15	FES	1.92150452
16	PIM2	1.89606674
17	SYK	1.83029940
18	BTK	1.74627309
19	ERN1	1.73163390
20	MAP3K11	1.71973888
21	MAP4K2	1.69026216
22	GRK6	1.53084261
23	PIK3CG	1.47373909
24	VRK1	1.39290771
25	TNK2	1.37128367
26	DAPK1	1.36068522
27	CCNB1	1.35521104
28	ITK	1.29785955
29	TXK	1.28185110
30	JAK3	1.27957753
31	MAPKAPK3	1.26395985
32	IKBKB	1.22529142
33	RPS6KB2	1.17613439
34	IKBKE	1.13682474
35	BMPR2	1.05755412
36	MATK	0.99345932
37	LYN	0.97185504
38	MAP2K3	0.96971244
39	MAPKAPK5	0.86763961
40	LCK	0.86623585
41	TIE1	0.85258252
42	ARAF	0.84917513
43	PBK	0.81144501
44	ADRBK2	0.77489305
45	ZAK	0.77425562
46	PRKCQ	0.77391741
47	HCK	0.71427243
48	CDC7	0.69855954
49	PIM1	0.69556472
50	TAF1	0.69053023
51	MAP3K14	0.68731182
52	BMPR1B	0.68595119
53	ATR	0.66789074
54	MAPK13	0.66562014
55	RPS6KA5	0.65805759
56	STK16	0.64393473
57	RIPK4	0.64340693
58	CSNK1G3	0.63954868
59	DAPK2	0.60513326
60	EIF2AK3	0.57548983
61	MAP3K5	0.57460305
62	CDK19	0.56675182
63	TLK1	0.56173383
64	MAP2K2	0.55109967
65	EIF2AK2	0.53346202
66	ABL2	0.49827952
67	PINK1	0.47607734
68	MAP3K13	0.46276061
69	GRK1	0.45565809
70	MAP2K6	0.44633436
71	ZAP70	0.44443091
72	RPS6KA6	0.43698610
73	INSRR	0.42603519
74	CSNK1G2	0.41651621
75	GRK5	0.40246816
76	RPS6KL1	0.40208800
77	RPS6KC1	0.40208800
78	HIPK2	0.39772117
79	CSNK1A1L	0.39680876
80	MAPK3	0.34681741
81	ADRBK1	0.34138680
82	ABL1	0.33875402
83	CDK9	0.32817023
84	MAPK11	0.32762583
85	RAF1	0.32454240
86	BLK	0.32454069
87	CSNK2A2	0.32151465
88	IGF1R	0.31667177
89	MAPK12	0.31318615
90	DAPK3	0.30765489
91	CSNK1G1	0.29969651
92	CSNK2A1	0.28921278
93	DYRK2	0.28085285
94	PRKCD	0.27380763
95	CDK7	0.27304154
96	CDK8	0.27021662
97	AURKA	0.26474307
98	PRKCA	0.26338150
99	LRRK2	0.25361365
100	MAPK4	0.23552057

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.77007559
2	Primary immunodeficiency_Homo sapiens_hsa05340	3.47832671
3	Allograft rejection_Homo sapiens_hsa05330	3.27885250
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.23205026
5	Base excision repair_Homo sapiens_hsa03410	3.01715444
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.99985322
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.98678293
8	Type I diabetes mellitus_Homo sapiens_hsa04940	2.70987688
9	Ribosome_Homo sapiens_hsa03010	2.52322145
10	DNA replication_Homo sapiens_hsa03030	2.49927490
11	Antigen processing and presentation_Homo sapiens_hsa04612	2.18163717
12	Homologous recombination_Homo sapiens_hsa03440	1.97955370
13	Leishmaniasis_Homo sapiens_hsa05140	1.81577262
14	Proteasome_Homo sapiens_hsa03050	1.79006258
15	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.78646968
16	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.73651554
17	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.61315716
18	Non-homologous end-joining_Homo sapiens_hsa03450	1.55199568
19	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.54478635
20	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.53139239
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.50878582
22	Mismatch repair_Homo sapiens_hsa03430	1.46539300
23	Peroxisome_Homo sapiens_hsa04146	1.45289205
24	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.43920694
25	Pyrimidine metabolism_Homo sapiens_hsa00240	1.43896434
26	Parkinsons disease_Homo sapiens_hsa05012	1.42325319
27	RNA polymerase_Homo sapiens_hsa03020	1.41001589
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.39518182
29	Viral myocarditis_Homo sapiens_hsa05416	1.34850028
30	Rheumatoid arthritis_Homo sapiens_hsa05323	1.34515876
31	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.34493149
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.27807132
33	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.22354208
34	Herpes simplex infection_Homo sapiens_hsa05168	1.20728713
35	Purine metabolism_Homo sapiens_hsa00230	1.19703136
36	Platelet activation_Homo sapiens_hsa04611	1.19609313
37	Oxidative phosphorylation_Homo sapiens_hsa00190	1.14723671
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.13821793
39	Nucleotide excision repair_Homo sapiens_hsa03420	1.13104940
40	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.06391347
41	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.05675971
42	Pentose phosphate pathway_Homo sapiens_hsa00030	1.01004783
43	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.94911899
44	Glutathione metabolism_Homo sapiens_hsa00480	0.93779663
45	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.93273257
46	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.88751592
47	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.87713830
48	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.84923190
49	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.84920315
50	Fatty acid elongation_Homo sapiens_hsa00062	0.84156985
51	Linoleic acid metabolism_Homo sapiens_hsa00591	0.83657637
52	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.81532759
53	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.79178669
54	One carbon pool by folate_Homo sapiens_hsa00670	0.78867697
55	Phototransduction_Homo sapiens_hsa04744	0.78825254
56	Spliceosome_Homo sapiens_hsa03040	0.78606118
57	Tuberculosis_Homo sapiens_hsa05152	0.77058602
58	Chemical carcinogenesis_Homo sapiens_hsa05204	0.73538386
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.71913435
60	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.69138581
61	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.66390901
62	Influenza A_Homo sapiens_hsa05164	0.65416069
63	Tryptophan metabolism_Homo sapiens_hsa00380	0.65306795
64	Olfactory transduction_Homo sapiens_hsa04740	0.64178855
65	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.63646451
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.63062659
67	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.61615931
68	RNA degradation_Homo sapiens_hsa03018	0.60142026
69	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.59999254
70	Regulation of autophagy_Homo sapiens_hsa04140	0.58284415
71	Butanoate metabolism_Homo sapiens_hsa00650	0.56173353
72	Propanoate metabolism_Homo sapiens_hsa00640	0.56142118
73	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.56120437
74	Huntingtons disease_Homo sapiens_hsa05016	0.55150627
75	Toxoplasmosis_Homo sapiens_hsa05145	0.52053105
76	Caffeine metabolism_Homo sapiens_hsa00232	0.51511825
77	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.50669115
78	Alzheimers disease_Homo sapiens_hsa05010	0.49597429
79	Nitrogen metabolism_Homo sapiens_hsa00910	0.49210185
80	Metabolic pathways_Homo sapiens_hsa01100	0.48804299
81	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.47454716
82	African trypanosomiasis_Homo sapiens_hsa05143	0.44135589
83	Ether lipid metabolism_Homo sapiens_hsa00565	0.43144123
84	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.42336255
85	Other glycan degradation_Homo sapiens_hsa00511	0.40750485
86	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.37538154
87	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.35327870
88	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.34654206
89	Carbon metabolism_Homo sapiens_hsa01200	0.34350927
90	Fatty acid metabolism_Homo sapiens_hsa01212	0.33818467
91	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.33477232
92	Fatty acid degradation_Homo sapiens_hsa00071	0.33447028
93	Acute myeloid leukemia_Homo sapiens_hsa05221	0.32040311
94	RNA transport_Homo sapiens_hsa03013	0.31858248
95	Measles_Homo sapiens_hsa05162	0.31488884
96	Retinol metabolism_Homo sapiens_hsa00830	0.31312031
97	Pertussis_Homo sapiens_hsa05133	0.31156178
98	Sulfur relay system_Homo sapiens_hsa04122	0.29739735
99	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.29354837
100	Salivary secretion_Homo sapiens_hsa04970	0.28863104

KIAA0125P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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