KIAA0141

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)6.36245196
2positive regulation of gamma-delta T cell activation (GO:0046645)5.15314431
3response to peptidoglycan (GO:0032494)4.37901870
4mannose metabolic process (GO:0006013)4.00413238
5pinocytosis (GO:0006907)3.92658043
6positive regulation by symbiont of host defense response (GO:0052509)3.89510759
7modulation by symbiont of host defense response (GO:0052031)3.89510759
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.89510759
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.89510759
10positive regulation by organism of defense response of other organism involved in symbiotic interact3.89510759
11modulation by symbiont of host immune response (GO:0052553)3.89510759
12regulation of gamma-delta T cell activation (GO:0046643)3.79937305
13regulation of gamma-delta T cell differentiation (GO:0045586)3.74407896
14response to muramyl dipeptide (GO:0032495)3.67656090
15antigen processing and presentation of endogenous antigen (GO:0019883)3.65156181
16detection of other organism (GO:0098543)3.58403967
17cellular extravasation (GO:0045123)3.57500699
18detection of bacterium (GO:0016045)3.57487391
19negative regulation of cell killing (GO:0031342)3.56447466
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.56447466
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.52051736
22positive regulation of B cell differentiation (GO:0045579)3.39031159
23positive thymic T cell selection (GO:0045059)3.38483283
24neutrophil activation involved in immune response (GO:0002283)3.30740844
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.24624375
26B cell receptor signaling pathway (GO:0050853)3.21962739
273-UTR-mediated mRNA stabilization (GO:0070935)3.20294039
28detection of external biotic stimulus (GO:0098581)3.10884953
29negative regulation of granulocyte differentiation (GO:0030853)3.06426105
30pentose-phosphate shunt (GO:0006098)3.05444719
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.02715402
32regulation of myeloid leukocyte mediated immunity (GO:0002886)3.01886618
33macrophage activation involved in immune response (GO:0002281)2.93681457
34regulation of leukocyte degranulation (GO:0043300)2.92432015
35tricarboxylic acid metabolic process (GO:0072350)2.91917923
36immunoglobulin mediated immune response (GO:0016064)2.87734694
37detection of biotic stimulus (GO:0009595)2.87678830
38cellular response to thyroid hormone stimulus (GO:0097067)2.86792828
39regulation of mast cell degranulation (GO:0043304)2.83405879
40detection of molecule of bacterial origin (GO:0032490)2.82586136
41thymic T cell selection (GO:0045061)2.79944943
42response to laminar fluid shear stress (GO:0034616)2.76560404
43barbed-end actin filament capping (GO:0051016)2.75605832
44regulation of B cell differentiation (GO:0045577)2.72068134
45urea cycle (GO:0000050)2.69821747
46response to thyroid hormone (GO:0097066)2.68218845
47NADPH regeneration (GO:0006740)2.67644450
48NADH metabolic process (GO:0006734)2.67308132
49stress fiber assembly (GO:0043149)2.65878306
50regulation of necroptotic process (GO:0060544)2.65482494
51response to host (GO:0075136)2.65385780
52response to host defenses (GO:0052200)2.65385780
53response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.65385780
54positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.65336568
55response to host immune response (GO:0052572)2.65135538
56response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.65135538
57negative regulation of necroptotic process (GO:0060546)2.65033227
58regulation of ARF GTPase activity (GO:0032312)2.62533628
59negative regulation of myotube differentiation (GO:0010832)2.61715584
60regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.60817698
61regulation of B cell receptor signaling pathway (GO:0050855)2.59239419
62negative regulation of leukocyte mediated immunity (GO:0002704)2.57459691
63negative regulation of lymphocyte mediated immunity (GO:0002707)2.56219318
64creatine metabolic process (GO:0006600)2.55532645
65oxaloacetate metabolic process (GO:0006107)2.55297063
66positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.53891302
67urea metabolic process (GO:0019627)2.53239871
68viral transcription (GO:0019083)2.51031420
69respiratory burst (GO:0045730)2.50842461
70regulation of ARF protein signal transduction (GO:0032012)2.49083443
71positive regulation of myotube differentiation (GO:0010831)2.48965723
72regulation of macrophage cytokine production (GO:0010935)2.48413802
73T cell selection (GO:0045058)2.48239637
74epithelial cell differentiation involved in prostate gland development (GO:0060742)2.47511121
75embryonic process involved in female pregnancy (GO:0060136)2.47046276
76regulation of extracellular matrix disassembly (GO:0010715)2.45061666
77complement activation, alternative pathway (GO:0006957)2.44341177
78positive regulation of cellular amide metabolic process (GO:0034250)2.43861425
79cellular hyperosmotic response (GO:0071474)2.43489186
80myeloid cell activation involved in immune response (GO:0002275)2.41294670
81glucose catabolic process (GO:0006007)2.40030004
82regulation of granulocyte differentiation (GO:0030852)2.39224765
83regulation of monocyte differentiation (GO:0045655)2.38576299
84negative thymic T cell selection (GO:0045060)2.38404775
85regulation of mast cell activation involved in immune response (GO:0033006)2.37748987
86positive regulation of Rap GTPase activity (GO:0032854)2.37565621
87regulation of type I interferon-mediated signaling pathway (GO:0060338)2.35189310
88regulation of phagocytosis (GO:0050764)2.34557955
89negative regulation of interleukin-12 production (GO:0032695)2.32364115
90nitrogen cycle metabolic process (GO:0071941)2.31526909
91positive regulation of phagocytosis (GO:0050766)2.31034631
92histone H4 deacetylation (GO:0070933)2.30875827
93negative regulation of innate immune response (GO:0045824)2.30602095
94regulation of interleukin-2 biosynthetic process (GO:0045076)2.29951915
95regulation of extracellular matrix organization (GO:1903053)2.29705449
96negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.28904966
97peptide catabolic process (GO:0043171)2.27788633
98positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.26957448
99germinal center formation (GO:0002467)2.26728081
100modulation by symbiont of host cellular process (GO:0044068)2.25683641

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.45207826
2MYC_22102868_ChIP-Seq_BL_Human3.08955443
3EGR1_19374776_ChIP-ChIP_THP-1_Human2.57633287
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.47991149
5* LXR_22292898_ChIP-Seq_THP-1_Human2.43040590
6KDM2B_26808549_Chip-Seq_SUP-B15_Human2.36360016
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.36179435
8NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.35633370
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.33801785
10TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33691561
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.33667515
12TCF7_22412390_ChIP-Seq_EML_Mouse2.32760928
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.27540686
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.27280212
15VDR_24763502_ChIP-Seq_THP-1_Human2.25258930
16KDM2B_26808549_Chip-Seq_DND41_Human2.18236598
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.14834045
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.12605248
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.02916487
20MAF_26560356_Chip-Seq_TH1_Human2.00825135
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.93832388
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.89676634
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83852034
24BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78466221
25UTX_26944678_Chip-Seq_JUKART_Human1.77369097
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77362422
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.75114480
28KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.73313689
29RACK7_27058665_Chip-Seq_MCF-7_Human1.71741720
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.71230005
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.68798450
32MAF_26560356_Chip-Seq_TH2_Human1.68666492
33* SPI1_23127762_ChIP-Seq_K562_Human1.65428803
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.63701797
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.63507078
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.57585708
37* SPI1_23547873_ChIP-Seq_NB4_Human1.56980569
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.54648449
39SCL_19346495_ChIP-Seq_HPC-7_Human1.52309878
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48266871
41GATA1_22383799_ChIP-Seq_G1ME_Mouse1.46400193
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.45125787
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42934928
44KDM2B_26808549_Chip-Seq_JURKAT_Human1.42666313
45TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40029113
46SA1_27219007_Chip-Seq_ERYTHROID_Human1.38603170
47GATA1_19941827_ChIP-Seq_MEL_Mouse1.38265469
48CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37934973
49PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34726737
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.32482453
51IRF8_27001747_Chip-Seq_BMDM_Mouse1.30610373
52P68_20966046_ChIP-Seq_HELA_Human1.30033826
53SMC4_20622854_ChIP-Seq_HELA_Human1.28155530
54CLOCK_20551151_ChIP-Seq_293T_Human1.28123079
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27567058
56PPARA_22158963_ChIP-Seq_LIVER_Mouse1.27009473
57ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26730207
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25836395
59KDM2B_26808549_Chip-Seq_K562_Human1.23962749
60STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.22401745
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21492039
62RXR_22158963_ChIP-Seq_LIVER_Mouse1.19523346
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19177343
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18397298
65PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18123605
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17955502
67ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17908270
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17728377
69FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16034566
70NCOR1_26117541_ChIP-Seq_K562_Human1.16007409
71* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15716585
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13910152
73TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13646010
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13177723
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12218847
76CIITA_25753668_ChIP-Seq_RAJI_Human1.11778161
77MYB_26560356_Chip-Seq_TH1_Human1.11214366
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11138520
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11079108
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10568467
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09990343
82STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09911460
83KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09086553
84PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08373095
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07612945
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07419786
87CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06939367
88BCOR_27268052_Chip-Seq_Bcells_Human1.06526999
89SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05501011
90ELF1_20517297_ChIP-Seq_JURKAT_Human1.05278114
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05161558
92MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05073281
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04577303
94TP63_17297297_ChIP-ChIP_HaCaT_Human1.04094244
95STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03738574
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03230614
97ESR2_21235772_ChIP-Seq_MCF-7_Human1.02758728
98MYB_26560356_Chip-Seq_TH2_Human1.02639180
99CREB1_26743006_Chip-Seq_LNCaP_Human1.01644158
100CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00891368

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.75961562
2MP0003303_peritoneal_inflammation3.58163452
3MP0005058_abnormal_lysosome_morphology3.48996251
4MP0008260_abnormal_autophagy2.92428168
5MP0003172_abnormal_lysosome_physiology2.75961921
6MP0002396_abnormal_hematopoietic_system2.54159483
7MP0003705_abnormal_hypodermis_morpholog2.36513317
8MP0003300_gastrointestinal_ulcer2.23814879
9MP0002419_abnormal_innate_immunity2.20222723
10MP0003191_abnormal_cellular_cholesterol2.11580234
11MP0001835_abnormal_antigen_presentation2.08895105
12MP0005451_abnormal_body_composition1.99146697
13MP0002009_preneoplasia1.98374891
14MP0003828_pulmonary_edema1.94069609
15MP0002132_abnormal_respiratory_system1.87997263
16MP0005464_abnormal_platelet_physiology1.87735581
17MP0005025_abnormal_response_to1.85966862
18MP0009278_abnormal_bone_marrow1.85876114
19MP0001533_abnormal_skeleton_physiology1.84787078
20MP0005000_abnormal_immune_tolerance1.72092095
21MP0000751_myopathy1.70009565
22MP0000685_abnormal_immune_system1.68540759
23MP0001800_abnormal_humoral_immune1.66610401
24MP0003763_abnormal_thymus_physiology1.59818186
25MP0002420_abnormal_adaptive_immunity1.57687247
26MP0005666_abnormal_adipose_tissue1.57562376
27MP0001819_abnormal_immune_cell1.56554067
28MP0003724_increased_susceptibility_to1.55726004
29MP0004808_abnormal_hematopoietic_stem1.55314860
30MP0000858_altered_metastatic_potential1.55200634
31MP0002723_abnormal_immune_serum1.54294759
32MP0009840_abnormal_foam_cell1.54015829
33MP0002452_abnormal_antigen_presenting1.50025811
34MP0010630_abnormal_cardiac_muscle1.49437056
35MP0001853_heart_inflammation1.48830707
36MP0001790_abnormal_immune_system1.47866868
37MP0005387_immune_system_phenotype1.47866868
38MP0000747_muscle_weakness1.45674312
39MP0001545_abnormal_hematopoietic_system1.43475999
40MP0005397_hematopoietic_system_phenotyp1.43475999
41MP0001851_eye_inflammation1.42800921
42MP0004185_abnormal_adipocyte_glucose1.42235282
43MP0002998_abnormal_bone_remodeling1.41091975
44MP0004510_myositis1.38106792
45MP0005670_abnormal_white_adipose1.35823500
46MP0004087_abnormal_muscle_fiber1.35406475
47MP0005330_cardiomyopathy1.34578830
48MP0002398_abnormal_bone_marrow1.34262852
49MP0010155_abnormal_intestine_physiology1.31831689
50MP0004947_skin_inflammation1.29383681
51MP0005076_abnormal_cell_differentiation1.27225962
52MP0001849_ear_inflammation1.27071574
53MP0000716_abnormal_immune_system1.26583577
54MP0006138_congestive_heart_failure1.25480957
55MP0005409_darkened_coat_color1.23480514
56MP0003075_altered_response_to1.22906435
57MP0010368_abnormal_lymphatic_system1.22147872
58MP0000759_abnormal_skeletal_muscle1.20377683
59MP0002139_abnormal_hepatobiliary_system1.19602929
60MP0001661_extended_life_span1.18237332
61MP0002722_abnormal_immune_system1.15158248
62MP0003566_abnormal_cell_adhesion1.14292647
63MP0004036_abnormal_muscle_relaxation1.11528435
64MP0002429_abnormal_blood_cell1.11512445
65MP0000689_abnormal_spleen_morphology1.10994847
66MP0004858_abnormal_nervous_system1.09493573
67MP0002405_respiratory_system_inflammati1.08450464
68MP0000703_abnormal_thymus_morphology1.08420112
69MP0008469_abnormal_protein_level1.07749387
70MP0000733_abnormal_muscle_development1.06264019
71MP0004233_abnormal_muscle_weight1.05405358
72MP0004130_abnormal_muscle_cell1.04504927
73MP0002166_altered_tumor_susceptibility1.03545757
74MP0005375_adipose_tissue_phenotype1.03404982
75MP0001845_abnormal_inflammatory_respons1.02865178
76MP0000465_gastrointestinal_hemorrhage1.02453560
77MP0003690_abnormal_glial_cell0.96919736
78MP0003183_abnormal_peptide_metabolism0.94215070
79MP0002971_abnormal_brown_adipose0.93588981
80MP0004084_abnormal_cardiac_muscle0.93519515
81MP0005390_skeleton_phenotype0.92942445
82MP0006082_CNS_inflammation0.91545314
83MP0000750_abnormal_muscle_regeneration0.91443295
84MP0003453_abnormal_keratinocyte_physiol0.91427734
85MP0000343_altered_response_to0.90511395
86MP0002933_joint_inflammation0.90181815
87MP0009333_abnormal_splenocyte_physiolog0.89886004
88MP0003279_aneurysm0.88693182
89MP0009785_altered_susceptibility_to0.88567021
90MP0003091_abnormal_cell_migration0.88177658
91MP0002148_abnormal_hypersensitivity_rea0.84261923
92MP0002269_muscular_atrophy0.83536473
93MP0005360_urolithiasis0.83055156
94MP0008004_abnormal_stomach_pH0.80127983
95MP0000749_muscle_degeneration0.77120196
96MP0005365_abnormal_bile_salt0.76377912
97MP0009115_abnormal_fat_cell0.74871641
98MP0004883_abnormal_blood_vessel0.72202517
99MP0000604_amyloidosis0.71627339
100MP0008874_decreased_physiological_sensi0.70824910

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)3.75355239
2Centrally nucleated skeletal muscle fibers (HP:0003687)3.49282292
3Recurrent gram-negative bacterial infections (HP:0005420)3.29971768
4Recurrent abscess formation (HP:0002722)3.24227098
5Recurrent bacterial skin infections (HP:0005406)3.13809109
6Colitis (HP:0002583)3.08314627
7Asymmetric septal hypertrophy (HP:0001670)3.01781255
8Obstructive lung disease (HP:0006536)2.88574523
9Chronic obstructive pulmonary disease (HP:0006510)2.88574523
10Abnormality of macrophages (HP:0004311)2.84832315
11Ragged-red muscle fibers (HP:0003200)2.84210729
12Distal lower limb muscle weakness (HP:0009053)2.80666987
13Cellulitis (HP:0100658)2.78326205
14Systemic lupus erythematosus (HP:0002725)2.72348350
15Spontaneous hematomas (HP:0007420)2.67658130
16Dysostosis multiplex (HP:0000943)2.66752442
17Amyloidosis (HP:0011034)2.60455393
18Exercise-induced myalgia (HP:0003738)2.56667205
19Prolonged bleeding time (HP:0003010)2.55460570
20Abnormality of skeletal muscle fiber size (HP:0012084)2.51163078
21Thrombocytosis (HP:0001894)2.50750216
22Gingivitis (HP:0000230)2.49352129
23Increased variability in muscle fiber diameter (HP:0003557)2.47123018
24Abnormality of the fingertips (HP:0001211)2.46280633
25Increased connective tissue (HP:0009025)2.44940562
26Fatigue (HP:0012378)2.43446370
27Myositis (HP:0100614)2.42836974
28Gastrointestinal inflammation (HP:0004386)2.41817084
29Thoracic kyphosis (HP:0002942)2.39400653
30Complement deficiency (HP:0004431)2.37069701
31Abnormality of complement system (HP:0005339)2.36797736
32Deep venous thrombosis (HP:0002625)2.35944912
33Gastrointestinal infarctions (HP:0005244)2.34263214
34Meningitis (HP:0001287)2.30719227
35Inflammation of the large intestine (HP:0002037)2.30161091
36Polycythemia (HP:0001901)2.30017023
37Abnormal delayed hypersensitivity skin test (HP:0002963)2.26858408
38Metaphyseal cupping (HP:0003021)2.24817188
39Chest pain (HP:0100749)2.24032237
40Mediastinal lymphadenopathy (HP:0100721)2.23951747
41Epistaxis (HP:0000421)2.23909191
42Recurrent skin infections (HP:0001581)2.22733227
43Abnormality of the thoracic spine (HP:0100711)2.22156394
44Increased cerebral lipofuscin (HP:0011813)2.21696306
45Interstitial pulmonary disease (HP:0006530)2.17653218
46Mucopolysacchariduria (HP:0008155)2.16889685
47Urinary glycosaminoglycan excretion (HP:0003541)2.16889685
48Increased IgE level (HP:0003212)2.14734217
49Distal lower limb amyotrophy (HP:0008944)2.14221163
50Hypertensive crisis (HP:0100735)2.13851162
51Vertebral compression fractures (HP:0002953)2.10787771
52Cerebral aneurysm (HP:0004944)2.09235430
53Agammaglobulinemia (HP:0004432)2.09221683
54Myopathic facies (HP:0002058)2.09051912
55Hemorrhage of the eye (HP:0011885)2.06156924
56Abnormality of mucopolysaccharide metabolism (HP:0011020)2.02165705
57Abnormality of polysaccharide metabolism (HP:0011012)2.02165705
58Abnormality of glycosaminoglycan metabolism (HP:0004371)2.02165705
59Purpura (HP:0000979)1.99325691
60Polygenic inheritance (HP:0010982)1.98623600
61Progressive muscle weakness (HP:0003323)1.97245799
62Recurrent fungal infections (HP:0002841)1.95107276
63Petechiae (HP:0000967)1.94247168
64Seborrheic dermatitis (HP:0001051)1.92418213
65Ventricular tachycardia (HP:0004756)1.91798566
66Elevated erythrocyte sedimentation rate (HP:0003565)1.90469196
67Obstructive sleep apnea (HP:0002870)1.90267960
68Recurrent cutaneous fungal infections (HP:0011370)1.88134913
69Chronic mucocutaneous candidiasis (HP:0002728)1.88134913
70Viral hepatitis (HP:0006562)1.87436415
71Flat acetabular roof (HP:0003180)1.86826673
72Orchitis (HP:0100796)1.85689534
73Recurrent viral infections (HP:0004429)1.82441692
74Gingival bleeding (HP:0000225)1.80217353
75Easy fatigability (HP:0003388)1.79424547
76Abnormality of the lumbar spine (HP:0100712)1.79205426
77Increased neuronal autofluorescent lipopigment (HP:0002074)1.78964541
78Neonatal hypoglycemia (HP:0001998)1.78559538
79Difficulty running (HP:0009046)1.78158382
80Rhabdomyolysis (HP:0003201)1.77718386
81Urticaria (HP:0001025)1.76102301
82Broad face (HP:0000283)1.74797452
83Protrusio acetabuli (HP:0003179)1.74191977
84Glomerulonephritis (HP:0000099)1.72399629
85Vasculitis (HP:0002633)1.72026648
86EMG: myopathic abnormalities (HP:0003458)1.70013377
87Reticulocytosis (HP:0001923)1.69739772
88Abnormality of glycolipid metabolism (HP:0010969)1.69705397
89Abnormality of liposaccharide metabolism (HP:0010968)1.69705397
90Abnormality of glycosphingolipid metabolism (HP:0004343)1.69705397
91Osteomyelitis (HP:0002754)1.69643841
92Dysmetric saccades (HP:0000641)1.69164483
93Abnormality of the periventricular white matter (HP:0002518)1.68509961
94Papilledema (HP:0001085)1.67886246
95Abnormal platelet function (HP:0011869)1.67860035
96Impaired platelet aggregation (HP:0003540)1.67860035
97Slow saccadic eye movements (HP:0000514)1.67418160
98Nemaline bodies (HP:0003798)1.66389833
99Arterial thrombosis (HP:0004420)1.65639882
100Muscle stiffness (HP:0003552)1.64544954

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.87291890
2TRIB33.71106224
3PRPF4B3.25093285
4EEF2K2.55646351
5MAP2K32.54081982
6MAP4K12.39638783
7RIPK42.24316491
8FES2.17111124
9SMG12.12838359
10TYK22.03214527
11FGFR41.93101675
12RIPK11.92207798
13TTN1.82819493
14ICK1.82201300
15EPHB11.77872870
16CDK121.75215855
17SIK11.67258040
18MAP3K131.61695589
19TNK21.59326426
20MARK21.55992829
21JAK31.55888382
22BLK1.54019082
23ZAP701.41823050
24TBK11.32724020
25MAPK121.31511171
26IRAK41.27645236
27MAP3K101.25495414
28MAP3K71.17009714
29BTK1.16318670
30PDK21.14965082
31CSK1.14099041
32PTK61.12693676
33MAP3K31.10236037
34PDPK11.02834895
35KSR21.02466057
36HCK0.98389787
37IRAK30.95621631
38MAP3K10.95504074
39RPS6KL10.92962822
40RPS6KC10.92962822
41ITK0.92329215
42MUSK0.89690497
43TESK20.89316445
44JAK10.88810428
45SYK0.85248968
46PKN20.85214061
47NME20.85084652
48TAOK10.84498377
49GRK60.84432903
50MAPK70.84220187
51SIK20.83759494
52TAOK20.82852277
53PRKD20.82613896
54CDC42BPA0.80620955
55DMPK0.80450705
56PDK10.79484295
57MAP3K140.78663787
58KIT0.77856724
59PASK0.77756943
60JAK20.77254296
61MAP3K110.76076252
62CDK60.74489333
63CSF1R0.73168697
64MTOR0.71442169
65MAPK110.70362617
66PDGFRA0.69215526
67PIK3CG0.68581535
68CAMKK10.68508259
69RPS6KA20.68243184
70RPS6KA60.66857638
71CDK40.66556203
72MAPKAPK30.66095616
73LRRK20.65178271
74STK160.63605401
75IKBKE0.62217318
76FGFR30.61579116
77LCK0.60568376
78LYN0.58498027
79NTRK10.57183752
80MATK0.56572334
81PAK40.55693821
82MAP3K60.55546006
83TEC0.55156625
84BMX0.55026252
85HIPK20.54780309
86MAP2K20.54663820
87RET0.54082341
88RPS6KB20.53611830
89NLK0.50917097
90KDR0.50351552
91DYRK1B0.50174052
92PRKD10.49533842
93MAPK40.46458339
94FGR0.46140121
95TGFBR20.43624759
96STK40.43581654
97TRPM70.43499833
98IKBKB0.42139104
99NEK90.41283806
100TYRO30.40997218

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.11467428
2Leishmaniasis_Homo sapiens_hsa051402.44198230
3Staphylococcus aureus infection_Homo sapiens_hsa051502.35205183
4Acute myeloid leukemia_Homo sapiens_hsa052212.18484121
5B cell receptor signaling pathway_Homo sapiens_hsa046622.14022378
6Osteoclast differentiation_Homo sapiens_hsa043802.10009893
7Notch signaling pathway_Homo sapiens_hsa043301.86054785
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.79236967
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.78313796
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.71606048
11Chronic myeloid leukemia_Homo sapiens_hsa052201.70053968
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.65109127
13Viral myocarditis_Homo sapiens_hsa054161.60037606
14Pentose phosphate pathway_Homo sapiens_hsa000301.57217183
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.55987549
16Non-small cell lung cancer_Homo sapiens_hsa052231.52901472
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.52224791
18Tuberculosis_Homo sapiens_hsa051521.44685131
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.43100010
20Toxoplasmosis_Homo sapiens_hsa051451.40950442
21VEGF signaling pathway_Homo sapiens_hsa043701.38828599
22Allograft rejection_Homo sapiens_hsa053301.35866518
23Autoimmune thyroid disease_Homo sapiens_hsa053201.26561069
24Graft-versus-host disease_Homo sapiens_hsa053321.25365951
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.24845811
26Influenza A_Homo sapiens_hsa051641.21673843
27Pancreatic cancer_Homo sapiens_hsa052121.20475106
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.18679488
29Leukocyte transendothelial migration_Homo sapiens_hsa046701.16290646
30Platelet activation_Homo sapiens_hsa046111.12601077
31Prion diseases_Homo sapiens_hsa050201.08915779
32Pertussis_Homo sapiens_hsa051331.07976971
33Lysosome_Homo sapiens_hsa041421.05779753
34Endometrial cancer_Homo sapiens_hsa052131.04809981
35Asthma_Homo sapiens_hsa053101.04685486
36Adipocytokine signaling pathway_Homo sapiens_hsa049201.04546278
37Neurotrophin signaling pathway_Homo sapiens_hsa047221.03014327
38Renal cell carcinoma_Homo sapiens_hsa052111.02549033
39Herpes simplex infection_Homo sapiens_hsa051680.98909217
40Insulin signaling pathway_Homo sapiens_hsa049100.97004666
41Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96731373
42Inositol phosphate metabolism_Homo sapiens_hsa005620.94975242
43Colorectal cancer_Homo sapiens_hsa052100.94339786
44Phospholipase D signaling pathway_Homo sapiens_hsa040720.94218697
45Carbon metabolism_Homo sapiens_hsa012000.91974731
46Complement and coagulation cascades_Homo sapiens_hsa046100.91765048
47T cell receptor signaling pathway_Homo sapiens_hsa046600.91696158
48Choline metabolism in cancer_Homo sapiens_hsa052310.91569938
49Measles_Homo sapiens_hsa051620.89412712
50Central carbon metabolism in cancer_Homo sapiens_hsa052300.89121681
51GnRH signaling pathway_Homo sapiens_hsa049120.88627632
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88416045
53Hepatitis B_Homo sapiens_hsa051610.88407062
54Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86737078
55Biosynthesis of amino acids_Homo sapiens_hsa012300.86228628
56Type I diabetes mellitus_Homo sapiens_hsa049400.85619210
57Antigen processing and presentation_Homo sapiens_hsa046120.85536165
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83686342
59Arginine biosynthesis_Homo sapiens_hsa002200.81518489
60Prolactin signaling pathway_Homo sapiens_hsa049170.81213564
61Fructose and mannose metabolism_Homo sapiens_hsa000510.80201346
62Insulin resistance_Homo sapiens_hsa049310.78016520
63mTOR signaling pathway_Homo sapiens_hsa041500.77486187
64Amoebiasis_Homo sapiens_hsa051460.77435804
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76765242
66Thyroid cancer_Homo sapiens_hsa052160.76536337
67Galactose metabolism_Homo sapiens_hsa000520.74913941
68Lysine degradation_Homo sapiens_hsa003100.73174142
69Hepatitis C_Homo sapiens_hsa051600.72955752
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72937286
71HTLV-I infection_Homo sapiens_hsa051660.72586362
72Apoptosis_Homo sapiens_hsa042100.72425411
73HIF-1 signaling pathway_Homo sapiens_hsa040660.72043095
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72043008
75TNF signaling pathway_Homo sapiens_hsa046680.71959087
76Chemokine signaling pathway_Homo sapiens_hsa040620.70260190
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.67551820
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67120867
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66999526
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.66484137
81Malaria_Homo sapiens_hsa051440.66231589
82Phagosome_Homo sapiens_hsa041450.65948281
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.64472531
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64244073
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62651474
86Dilated cardiomyopathy_Homo sapiens_hsa054140.62052836
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62052558
88Estrogen signaling pathway_Homo sapiens_hsa049150.59867694
89Endocytosis_Homo sapiens_hsa041440.59412802
90ErbB signaling pathway_Homo sapiens_hsa040120.57005506
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.55146628
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.55019041
93Ribosome_Homo sapiens_hsa030100.53939192
94PPAR signaling pathway_Homo sapiens_hsa033200.53935269
95Primary immunodeficiency_Homo sapiens_hsa053400.53396522
96Legionellosis_Homo sapiens_hsa051340.51146323
97Glioma_Homo sapiens_hsa052140.50865451
98Focal adhesion_Homo sapiens_hsa045100.50850146
99Hematopoietic cell lineage_Homo sapiens_hsa046400.49805204
100Fatty acid degradation_Homo sapiens_hsa000710.48675528

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