KIAA0196

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.69221111
2COPI coating of Golgi vesicle (GO:0048205)5.69221111
3nuclear pore complex assembly (GO:0051292)5.11872506
4nuclear pore organization (GO:0006999)4.46823936
5COPII vesicle coating (GO:0048208)4.00552175
6skin morphogenesis (GO:0043589)3.82462977
7protein localization to endosome (GO:0036010)3.80584064
8pore complex assembly (GO:0046931)3.69622834
9mitotic sister chromatid cohesion (GO:0007064)3.64176263
10cell adhesion mediated by integrin (GO:0033627)3.40251716
11vesicle coating (GO:0006901)3.38867880
12maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.37647737
13mammary gland epithelial cell proliferation (GO:0033598)3.34049543
14mitotic chromosome condensation (GO:0007076)3.30788756
15pinocytosis (GO:0006907)3.28392962
16retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.27356906
17protein retention in ER lumen (GO:0006621)3.27351688
18regulation of translational termination (GO:0006449)3.21467800
19embryonic process involved in female pregnancy (GO:0060136)3.17111090
20DNA unwinding involved in DNA replication (GO:0006268)3.13244787
21negative regulation of protein localization to plasma membrane (GO:1903077)3.12538705
22ribosome assembly (GO:0042255)3.11897935
23positive regulation of keratinocyte differentiation (GO:0045618)3.06872820
24desmosome organization (GO:0002934)3.06239504
25branching involved in mammary gland duct morphogenesis (GO:0060444)2.91988106
26membrane protein ectodomain proteolysis (GO:0006509)2.91470778
27hemidesmosome assembly (GO:0031581)2.91227898
28cellular protein complex localization (GO:0034629)2.89290714
29hypotonic response (GO:0006971)2.89121223
30protein localization to chromosome, centromeric region (GO:0071459)2.88287670
31cell-substrate junction assembly (GO:0007044)2.88187870
32positive regulation of receptor recycling (GO:0001921)2.88001476
33positive regulation of Cdc42 GTPase activity (GO:0043089)2.82585748
34protein hydroxylation (GO:0018126)2.80656808
35negative regulation of DNA repair (GO:0045738)2.77856362
36peptidyl-proline hydroxylation (GO:0019511)2.77501149
37protein complex localization (GO:0031503)2.76837112
38regulation of nucleobase-containing compound transport (GO:0032239)2.74921136
39regulation of RNA export from nucleus (GO:0046831)2.74863865
40pentose-phosphate shunt (GO:0006098)2.74268701
41protein export from nucleus (GO:0006611)2.74029653
42adherens junction assembly (GO:0034333)2.73730547
43regulation of early endosome to late endosome transport (GO:2000641)2.73424577
44iron ion import (GO:0097286)2.73117160
45barbed-end actin filament capping (GO:0051016)2.72950896
46regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.72772433
47epithelial cell-cell adhesion (GO:0090136)2.71840738
48focal adhesion assembly (GO:0048041)2.70268799
49cell-substrate adherens junction assembly (GO:0007045)2.70268799
50protein localization to microtubule (GO:0035372)2.68798748
51intestinal epithelial cell development (GO:0060576)2.66846931
52membrane raft organization (GO:0031579)2.66326937
53negative regulation of keratinocyte proliferation (GO:0010839)2.65610557
54NADPH regeneration (GO:0006740)2.64791821
55regulation of histone H3-K27 methylation (GO:0061085)2.64363445
56endoplasmic reticulum unfolded protein response (GO:0030968)2.63458870
57positive regulation of epidermal cell differentiation (GO:0045606)2.63111831
58ER-nucleus signaling pathway (GO:0006984)2.61983833
59regulation of translational fidelity (GO:0006450)2.60716508
60activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.60168799
61maternal placenta development (GO:0001893)2.59774606
62hyaluronan catabolic process (GO:0030214)2.59421396
63regulation of mitotic spindle organization (GO:0060236)2.59079552
64amyloid precursor protein catabolic process (GO:0042987)2.58022168
65positive regulation of nuclease activity (GO:0032075)2.53845908
66dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.53035118
67peptidyl-lysine dimethylation (GO:0018027)2.52157646
68localization within membrane (GO:0051668)2.51951142
69hepatocyte apoptotic process (GO:0097284)2.51672610
70mitotic metaphase plate congression (GO:0007080)2.51260237
71stress fiber assembly (GO:0043149)2.50729028
72activation of Rac GTPase activity (GO:0032863)2.47264618
73negative regulation of anoikis (GO:2000811)2.47113252
74NLS-bearing protein import into nucleus (GO:0006607)2.46760223
75trophectodermal cell differentiation (GO:0001829)2.43452431
76epithelial cell differentiation involved in prostate gland development (GO:0060742)2.43127661
77cellular response to unfolded protein (GO:0034620)2.41739644
78ER overload response (GO:0006983)2.40872981
79regulation of sister chromatid cohesion (GO:0007063)2.39089939
80regulation of spindle organization (GO:0090224)2.38940464
81negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.38765152
82DNA duplex unwinding (GO:0032508)2.38541533
83regulation of nuclease activity (GO:0032069)2.36943482
84negative regulation of fibroblast apoptotic process (GO:2000270)2.36818076
85positive regulation of macroautophagy (GO:0016239)2.36080946
86mitotic cytokinesis (GO:0000281)2.35905469
87establishment of integrated proviral latency (GO:0075713)2.35798562
88positive regulation of protein import into nucleus, translocation (GO:0033160)2.35142275
89chondrocyte development (GO:0002063)2.34749939
90regulation of mammary gland epithelial cell proliferation (GO:0033599)2.34736490
91formation of translation preinitiation complex (GO:0001731)2.31555299
92vagina development (GO:0060068)2.31215131
93protein localization to kinetochore (GO:0034501)2.31084781
94cytoskeleton-dependent cytokinesis (GO:0061640)2.30928794
95proline biosynthetic process (GO:0006561)2.30823751
96regulation of water loss via skin (GO:0033561)2.30313750
97regulation of protein localization to plasma membrane (GO:1903076)2.27858402
98viral entry into host cell (GO:0046718)2.27360787
99nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.27171270
100DNA topological change (GO:0006265)2.25638299

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.01356719
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.88459778
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.52895343
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.25526605
5AR_21909140_ChIP-Seq_LNCAP_Human3.07855857
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.82295020
7CLOCK_20551151_ChIP-Seq_293T_Human2.68526843
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.45076891
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.35918697
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.26921039
11PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.25748129
12SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.20274792
13ZNF263_19887448_ChIP-Seq_K562_Human2.18793931
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.15106565
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.06561565
16KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.03951992
17KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.03877398
18ZFX_18555785_ChIP-Seq_MESCs_Mouse2.02860558
19* TFEB_21752829_ChIP-Seq_HELA_Human2.00239940
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85021678
21NELFA_20434984_ChIP-Seq_ESCs_Mouse1.83103856
22MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80136908
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75431987
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.73972241
25MYB_21317192_ChIP-Seq_ERMYB_Mouse1.71204785
26SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.69457898
27SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.69457898
28CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.69220737
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.68737129
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68084193
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.64721380
32DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.62761871
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.61055951
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.56720481
35KLF4_18555785_ChIP-Seq_MESCs_Mouse1.55991412
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55493296
37ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52373947
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.51220080
39KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48591474
40EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.47921898
41CHD1_26751641_Chip-Seq_LNCaP_Human1.47050337
42TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.46413017
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.43922823
44RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.43744814
45CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.42313639
46MYC_19030024_ChIP-ChIP_MESCs_Mouse1.42294097
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41205010
48NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.40209063
49TRIM28_21343339_ChIP-Seq_HEK293_Human1.39664478
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.39514259
51DCP1A_22483619_ChIP-Seq_HELA_Human1.38721621
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.38462393
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37598011
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36747786
55ATF3_27146783_Chip-Seq_COLON_Human1.35902198
56FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.34668580
57ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.32506148
58MYC_22102868_ChIP-Seq_BL_Human1.32142473
59RACK7_27058665_Chip-Seq_MCF-7_Human1.29868928
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29732049
61SOX2_27498859_Chip-Seq_STOMACH_Mouse1.28573848
62P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27962860
63CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.27740144
64BRD4_25478319_ChIP-Seq_HGPS_Human1.26318297
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.23782544
66SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21017329
67PPAR_26484153_Chip-Seq_NCI-H1993_Human1.19836626
68RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17582951
69ELF5_23300383_ChIP-Seq_T47D_Human1.15666595
70BRD4_27068464_Chip-Seq_AML-cells_Mouse1.15282517
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14459583
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13908785
73SOX17_20123909_ChIP-Seq_XEN_Mouse1.13681839
74CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13447627
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13440987
76SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.12845899
77PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12427017
78GATA4_21415370_ChIP-Seq_HL-1_Mouse1.12144894
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10355515
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10325050
81WT1_19549856_ChIP-ChIP_CCG9911_Human1.10278205
82E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10097953
83ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10079370
84GATA3_24758297_ChIP-Seq_MCF-7_Human1.10016116
85ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09618759
86ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08896034
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07676196
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06718085
89UBF1/2_26484160_Chip-Seq_HMECs_Human1.04349600
90STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03810929
91MYC_18358816_ChIP-ChIP_MESCs_Mouse1.03463021
92FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.02302431
93STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01863324
94SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01158823
95STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99635007
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98674146
97GATA6_25053715_ChIP-Seq_YYC3_Human0.97015154
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96911650
99YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96785415
100FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96759600

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.55549995
2MP0002877_abnormal_melanocyte_morpholog3.54974117
3MP0010234_abnormal_vibrissa_follicle3.52399780
4MP0008438_abnormal_cutaneous_collagen3.45426217
5MP0010352_gastrointestinal_tract_polyps3.09937839
6MP0003566_abnormal_cell_adhesion2.69537658
7MP0008057_abnormal_DNA_replication2.60508670
8MP0003941_abnormal_skin_development2.60240486
9MP0004233_abnormal_muscle_weight2.42711516
10MP0006054_spinal_hemorrhage2.11023662
11MP0002796_impaired_skin_barrier2.07737261
12MP0005076_abnormal_cell_differentiation2.02676001
13MP0003191_abnormal_cellular_cholesterol1.98001185
14MP0002060_abnormal_skin_morphology1.85394250
15MP0002009_preneoplasia1.83470175
16MP0005257_abnormal_intraocular_pressure1.81619954
17MP0004272_abnormal_basement_membrane1.78102854
18MP0004957_abnormal_blastocyst_morpholog1.77085198
19MP0004264_abnormal_extraembryonic_tissu1.66298034
20MP0005451_abnormal_body_composition1.63409387
21MP0003300_gastrointestinal_ulcer1.61624638
22MP0005275_abnormal_skin_tensile1.61102085
23MP0005501_abnormal_skin_physiology1.60057130
24MP0003453_abnormal_keratinocyte_physiol1.59136138
25MP0004185_abnormal_adipocyte_glucose1.56267197
26MP0005058_abnormal_lysosome_morphology1.56123066
27MP0005623_abnormal_meninges_morphology1.54037889
28MP0003091_abnormal_cell_migration1.53030073
29MP0001849_ear_inflammation1.48678085
30MP0008007_abnormal_cellular_replicative1.46960594
31MP0010307_abnormal_tumor_latency1.46444116
32MP0003111_abnormal_nucleus_morphology1.46360781
33MP0003077_abnormal_cell_cycle1.44137530
34MP0010678_abnormal_skin_adnexa1.43062946
35MP0009780_abnormal_chondrocyte_physiolo1.41593577
36MP0008260_abnormal_autophagy1.39250620
37MP0003693_abnormal_embryo_hatching1.37356332
38MP0001730_embryonic_growth_arrest1.36154864
39MP0003950_abnormal_plasma_membrane1.34232034
40MP0005408_hypopigmentation1.34177916
41MP0000627_abnormal_mammary_gland1.33805796
42MP0010094_abnormal_chromosome_stability1.32920581
43MP0008932_abnormal_embryonic_tissue1.31606002
44MP0004782_abnormal_surfactant_physiolog1.30717257
45MP0005621_abnormal_cell_physiology1.26325230
46MP0000350_abnormal_cell_proliferation1.24813852
47MP0003221_abnormal_cardiomyocyte_apopto1.22215915
48MP0004808_abnormal_hematopoietic_stem1.21175795
49MP0001216_abnormal_epidermal_layer1.19382528
50MP0005023_abnormal_wound_healing1.18881537
51MP0001958_emphysema1.18527572
52MP0000377_abnormal_hair_follicle1.15581563
53MP0002396_abnormal_hematopoietic_system1.14217033
54MP0005248_abnormal_Harderian_gland1.11755533
55MP0009840_abnormal_foam_cell1.11086499
56MP0002086_abnormal_extraembryonic_tissu1.10969500
57MP0003279_aneurysm1.10568941
58MP0002166_altered_tumor_susceptibility1.10369876
59MP0000858_altered_metastatic_potential1.09984533
60MP0000569_abnormal_digit_pigmentation1.07483853
61MP0003984_embryonic_growth_retardation1.07385050
62MP0002896_abnormal_bone_mineralization1.07378990
63MP0001243_abnormal_dermal_layer1.07357564
64MP0002088_abnormal_embryonic_growth/wei1.04773662
65MP0005380_embryogenesis_phenotype1.03938110
66MP0001672_abnormal_embryogenesis/_devel1.03938110
67MP0001661_extended_life_span1.03039329
68MP0002080_prenatal_lethality1.01697150
69MP0009672_abnormal_birth_weight1.01555594
70MP0005409_darkened_coat_color0.99745842
71MP0000733_abnormal_muscle_development0.99376959
72MP0000467_abnormal_esophagus_morphology0.98033950
73MP0005384_cellular_phenotype0.96362288
74MP0001881_abnormal_mammary_gland0.94881928
75MP0001915_intracranial_hemorrhage0.94801800
76MP0001697_abnormal_embryo_size0.94757818
77MP0009384_cardiac_valve_regurgitation0.92709769
78MP0003448_altered_tumor_morphology0.92279845
79MP0002098_abnormal_vibrissa_morphology0.89185540
80MP0003828_pulmonary_edema0.89007966
81MP0009697_abnormal_copulation0.88036567
82MP0001542_abnormal_bone_strength0.87807032
83MP0000537_abnormal_urethra_morphology0.87663266
84MP0000383_abnormal_hair_follicle0.87634027
85MP0002269_muscular_atrophy0.87402531
86MP0005503_abnormal_tendon_morphology0.86152409
87MP0002006_tumorigenesis0.86133755
88MP0000762_abnormal_tongue_morphology0.85436625
89MP0000747_muscle_weakness0.83989812
90MP0000462_abnormal_digestive_system0.79654335
91MP0004197_abnormal_fetal_growth/weight/0.79036820
92MP0002085_abnormal_embryonic_tissue0.77009758
93MP0000465_gastrointestinal_hemorrhage0.76815742
94MP0002084_abnormal_developmental_patter0.76786046
95MP0010771_integument_phenotype0.75155527
96MP0001727_abnormal_embryo_implantation0.73752127
97MP0000371_diluted_coat_color0.73695301
98MP0004947_skin_inflammation0.72814544
99MP0000490_abnormal_crypts_of0.71949448
100MP0000767_abnormal_smooth_muscle0.71567894

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.29286356
2Osteolytic defects of the phalanges of the hand (HP:0009771)3.54576532
3Osteolytic defects of the hand bones (HP:0009699)3.54576532
4Protrusio acetabuli (HP:0003179)3.46383456
5Vertebral compression fractures (HP:0002953)3.21085747
6Asymmetry of the thorax (HP:0001555)3.16664905
7Ankle contracture (HP:0006466)3.12309245
8Absent frontal sinuses (HP:0002688)3.05754669
9Spinal cord lesions (HP:0100561)2.97631863
10Syringomyelia (HP:0003396)2.97631863
11Sparse lateral eyebrow (HP:0005338)2.89545933
12Deep philtrum (HP:0002002)2.82737881
13Vascular tortuosity (HP:0004948)2.74305535
14Arterial tortuosity (HP:0005116)2.73303665
15Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.64435056
16Cervical subluxation (HP:0003308)2.51995012
17Micronodular cirrhosis (HP:0001413)2.42684299
18Spinal rigidity (HP:0003306)2.40814597
19Subacute progressive viral hepatitis (HP:0006572)2.36552675
20Microglossia (HP:0000171)2.36341410
21Short nail (HP:0001799)2.36283279
22Wormian bones (HP:0002645)2.34294096
23Flat acetabular roof (HP:0003180)2.34198308
24Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.33880662
25Abnormality of the distal phalanges of the toes (HP:0010182)2.25056806
26Aortic dissection (HP:0002647)2.20306651
27Papillary thyroid carcinoma (HP:0002895)2.16763462
28Ankyloglossia (HP:0010296)2.15133689
29Atrophic scars (HP:0001075)2.14656057
30Right ventricular cardiomyopathy (HP:0011663)2.14269246
31Mitral stenosis (HP:0001718)2.10629470
32Increased connective tissue (HP:0009025)2.10103383
33Hyperacusis (HP:0010780)2.08350256
34Hypokinesia (HP:0002375)2.07426582
35J-shaped sella turcica (HP:0002680)2.05787008
36Aortic aneurysm (HP:0004942)2.03115618
37Selective tooth agenesis (HP:0001592)2.02872463
38Abnormality of oral frenula (HP:0000190)2.02397215
39Fragile skin (HP:0001030)2.01957357
40Tetraparesis (HP:0002273)2.01523967
41Curly hair (HP:0002212)1.97652600
42Cerebral aneurysm (HP:0004944)1.93187158
43Abnormality of the frontal sinuses (HP:0002687)1.90537037
44Ulnar bowing (HP:0003031)1.90483663
45Elbow flexion contracture (HP:0002987)1.89998727
46Deviation of the thumb (HP:0009603)1.88498371
47Autoamputation (HP:0001218)1.86743307
48Generalized amyotrophy (HP:0003700)1.86104549
49Achilles tendon contracture (HP:0001771)1.85944930
50Dilatation of the ascending aorta (HP:0005111)1.83376743
51Distal lower limb amyotrophy (HP:0008944)1.82716273
52Back pain (HP:0003418)1.81533258
53Spondylolisthesis (HP:0003302)1.81251655
54Long toe (HP:0010511)1.80919622
55Loss of speech (HP:0002371)1.80389591
56Distal lower limb muscle weakness (HP:0009053)1.80190474
57Abnormality of the acetabulum (HP:0003170)1.79774595
58Delayed cranial suture closure (HP:0000270)1.79724223
59Advanced eruption of teeth (HP:0006288)1.77581580
60* Termporal pattern (HP:0011008)1.77455066
61* Insidious onset (HP:0003587)1.77455066
62Blue sclerae (HP:0000592)1.77252130
63Delayed closure of the anterior fontanelle (HP:0001476)1.77195442
64Abnormality of skeletal muscle fiber size (HP:0012084)1.76298014
65Spastic diplegia (HP:0001264)1.75276632
66Relative macrocephaly (HP:0004482)1.74974083
67Abnormality of the thoracic spine (HP:0100711)1.74225237
68Deformed sella turcica (HP:0002681)1.72785473
69Coarse hair (HP:0002208)1.71867951
70Cutaneous melanoma (HP:0012056)1.71332795
71Bone pain (HP:0002653)1.71242436
72Thin bony cortex (HP:0002753)1.70586310
73Aneurysm (HP:0002617)1.68051760
74Natal tooth (HP:0000695)1.67909141
75Exostoses (HP:0100777)1.67875451
76Increased variability in muscle fiber diameter (HP:0003557)1.67768792
77Uterine leiomyosarcoma (HP:0002891)1.67544886
78Leiomyosarcoma (HP:0100243)1.67544886
79Proximal placement of thumb (HP:0009623)1.67034852
80Centrally nucleated skeletal muscle fibers (HP:0003687)1.65463070
81Entropion (HP:0000621)1.65168624
82Bladder diverticulum (HP:0000015)1.64596804
83Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.64197740
84Abnormality of liposaccharide metabolism (HP:0010968)1.64116706
85Abnormality of glycosphingolipid metabolism (HP:0004343)1.64116706
86Abnormality of glycolipid metabolism (HP:0010969)1.64116706
87Abnormality of the Achilles tendon (HP:0005109)1.63073635
88Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.62304134
89Abnormality of nail color (HP:0100643)1.62287155
90Distal upper limb amyotrophy (HP:0007149)1.62195132
91Upper limb amyotrophy (HP:0009129)1.62195132
92Joint laxity (HP:0001388)1.59715072
93Overgrowth (HP:0001548)1.59511555
94Breech presentation (HP:0001623)1.59383260
95Periodontitis (HP:0000704)1.58893794
96Follicular hyperkeratosis (HP:0007502)1.57727637
97Soft skin (HP:0000977)1.57601991
98Septate vagina (HP:0001153)1.55812327
99Reduced subcutaneous adipose tissue (HP:0003758)1.55469484
100Renal cell carcinoma (HP:0005584)1.55336486

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SCYL24.86532171
2TRIB32.89293788
3MST1R2.71635168
4IRAK32.62166625
5PDGFRA2.35920671
6EIF2AK12.34980151
7PAK42.32542277
8SMG12.31991514
9CDK122.31564493
10PBK2.20671672
11SIK12.18192551
12PKN22.10297158
13MET2.00108137
14CDK61.74506178
15TTN1.74423751
16EPHA21.72841937
17PTK21.59941926
18ICK1.58749329
19TSSK61.56037443
20RPS6KB21.53902464
21EEF2K1.51664791
22TTK1.45311156
23SIK31.44900144
24PRPF4B1.40002491
25EIF2AK31.36392434
26LATS21.35193784
27TESK11.35127813
28LATS11.28210347
29NEK91.27579237
30MAP3K141.24281322
31TAF11.23886526
32RIPK11.23551367
33MAP3K91.18481414
34FGFR41.17213109
35MAP3K101.10779094
36PAK21.10186967
37NEK11.08538065
38MAP3K121.08301189
39ERBB41.03236561
40MTOR1.02872675
41CDK71.02859255
42MYLK1.00766085
43MAP3K21.00727979
44NME20.92787967
45KSR20.91692965
46PDGFRB0.90786901
47TRPM70.89918449
48NEK60.86846723
49ERN10.85817366
50MAP3K60.85421106
51TRIM280.81673267
52ERBB30.81095958
53RPS6KA40.78073148
54KSR10.74498385
55YES10.74448904
56LMTK20.72658595
57BCR0.72228520
58CDK90.70310870
59MELK0.70201326
60MAP3K80.67446592
61AURKB0.65968910
62NTRK10.64558774
63FER0.63772542
64JAK10.61388138
65CAMK1G0.57388326
66BMPR20.57016715
67PTK60.56708832
68DDR20.55946200
69PIM20.55784467
70ILK0.55309483
71FLT30.53977085
72RPS6KA20.53088226
73BUB10.52211845
74ALK0.52138372
75RET0.52096396
76LIMK10.51549935
77EIF2AK20.51150082
78SRPK10.50261604
79BRSK20.50120430
80RPS6KB10.47592670
81EPHB10.47271432
82CAMK1D0.47112912
83STK100.46568287
84MATK0.43170149
85CLK10.41959637
86CHEK10.41596799
87STK390.41130813
88AKT20.40934760
89AKT30.38819195
90MAPKAPK20.38721674
91MAP3K30.38518661
92STK30.35238339
93BRAF0.35138515
94CDK40.34877609
95RAF10.34861252
96LRRK20.34146323
97ARAF0.32828269
98PIK3CA0.32821315
99MAP2K10.31640774
100MAP2K30.31392459

Predicted pathways (KEGG)

RankGene SetZ-score
1Thyroid cancer_Homo sapiens_hsa052162.47837446
2Chronic myeloid leukemia_Homo sapiens_hsa052202.04952954
3Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.00667575
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.00213900
5Bladder cancer_Homo sapiens_hsa052191.95020930
6Central carbon metabolism in cancer_Homo sapiens_hsa052301.92359812
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.89407810
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.81205828
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.79899227
10Endometrial cancer_Homo sapiens_hsa052131.79581917
11Pancreatic cancer_Homo sapiens_hsa052121.79176560
12Adherens junction_Homo sapiens_hsa045201.77281446
13Other glycan degradation_Homo sapiens_hsa005111.66588052
14Non-small cell lung cancer_Homo sapiens_hsa052231.64945870
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.58584098
16Proteoglycans in cancer_Homo sapiens_hsa052051.57976118
17Prostate cancer_Homo sapiens_hsa052151.57479673
18Pentose phosphate pathway_Homo sapiens_hsa000301.56086009
19Small cell lung cancer_Homo sapiens_hsa052221.54626535
20Cell cycle_Homo sapiens_hsa041101.53042868
21Renal cell carcinoma_Homo sapiens_hsa052111.48238213
22Acute myeloid leukemia_Homo sapiens_hsa052211.45875749
23Focal adhesion_Homo sapiens_hsa045101.43712863
24Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.41523111
25MicroRNAs in cancer_Homo sapiens_hsa052061.33376217
26Thyroid hormone signaling pathway_Homo sapiens_hsa049191.31153239
27Non-homologous end-joining_Homo sapiens_hsa034501.19465233
28Shigellosis_Homo sapiens_hsa051311.17100709
29mTOR signaling pathway_Homo sapiens_hsa041501.16689157
30Glioma_Homo sapiens_hsa052141.16551348
31Lysosome_Homo sapiens_hsa041421.16437611
32Vibrio cholerae infection_Homo sapiens_hsa051101.12161287
33Hepatitis B_Homo sapiens_hsa051611.11206532
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.09298123
35ECM-receptor interaction_Homo sapiens_hsa045121.08836783
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.07102281
37Regulation of actin cytoskeleton_Homo sapiens_hsa048101.05902275
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05861587
39Inositol phosphate metabolism_Homo sapiens_hsa005621.05579186
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05286986
41ErbB signaling pathway_Homo sapiens_hsa040121.03523855
42Colorectal cancer_Homo sapiens_hsa052101.02856615
43DNA replication_Homo sapiens_hsa030301.00493701
44Carbon metabolism_Homo sapiens_hsa012000.99527584
45RNA transport_Homo sapiens_hsa030130.99318262
46Amoebiasis_Homo sapiens_hsa051460.95971545
47AMPK signaling pathway_Homo sapiens_hsa041520.95924026
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95886154
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95355349
50Viral carcinogenesis_Homo sapiens_hsa052030.95316812
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94660882
52Hepatitis C_Homo sapiens_hsa051600.94161519
53Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94096308
54mRNA surveillance pathway_Homo sapiens_hsa030150.92470565
55Melanoma_Homo sapiens_hsa052180.91381836
56Lysine degradation_Homo sapiens_hsa003100.91361028
57Biosynthesis of amino acids_Homo sapiens_hsa012300.89449766
58Fatty acid elongation_Homo sapiens_hsa000620.88073345
59Insulin signaling pathway_Homo sapiens_hsa049100.87975171
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87496576
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85007931
62N-Glycan biosynthesis_Homo sapiens_hsa005100.83019235
63Galactose metabolism_Homo sapiens_hsa000520.82811044
64p53 signaling pathway_Homo sapiens_hsa041150.80935106
65Prolactin signaling pathway_Homo sapiens_hsa049170.80691979
66Apoptosis_Homo sapiens_hsa042100.79538329
67Estrogen signaling pathway_Homo sapiens_hsa049150.78734572
68Sphingolipid metabolism_Homo sapiens_hsa006000.74233559
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.73989807
70* Endocytosis_Homo sapiens_hsa041440.72519485
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.72079473
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71516017
73Vitamin B6 metabolism_Homo sapiens_hsa007500.67295628
74HIF-1 signaling pathway_Homo sapiens_hsa040660.66735511
75Tight junction_Homo sapiens_hsa045300.65080581
76Pathways in cancer_Homo sapiens_hsa052000.64553956
77VEGF signaling pathway_Homo sapiens_hsa043700.63700394
78PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63063100
79TGF-beta signaling pathway_Homo sapiens_hsa043500.62822873
80Insulin resistance_Homo sapiens_hsa049310.61238283
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60959496
82Hippo signaling pathway_Homo sapiens_hsa043900.59529711
83Choline metabolism in cancer_Homo sapiens_hsa052310.58557519
84B cell receptor signaling pathway_Homo sapiens_hsa046620.58093644
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57877113
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56730446
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56357823
88HTLV-I infection_Homo sapiens_hsa051660.55520480
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55197383
90Legionellosis_Homo sapiens_hsa051340.54269712
91Salmonella infection_Homo sapiens_hsa051320.54005894
92Notch signaling pathway_Homo sapiens_hsa043300.52244864
93Nucleotide excision repair_Homo sapiens_hsa034200.52115243
94Prion diseases_Homo sapiens_hsa050200.51867642
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51506584
96Measles_Homo sapiens_hsa051620.49437259
97Spliceosome_Homo sapiens_hsa030400.48836697
98Fatty acid metabolism_Homo sapiens_hsa012120.48508225
99Pyruvate metabolism_Homo sapiens_hsa006200.46842299
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46232632

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