KIAA0232

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcoplasmic reticulum calcium ion transport (GO:0070296)3.54855344
2macroautophagy (GO:0016236)3.44147054
3regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.40122008
4nerve growth factor signaling pathway (GO:0038180)3.36420196
5establishment of nucleus localization (GO:0040023)3.25968740
6regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.23353622
7regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.21050281
8presynaptic membrane assembly (GO:0097105)3.18804638
9membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.15739221
10cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.13245913
11positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.04806594
12nucleus localization (GO:0051647)3.02126145
13regulation of relaxation of muscle (GO:1901077)3.01503811
14myofibril assembly (GO:0030239)3.00099491
15regulation of actin filament-based movement (GO:1903115)2.88110493
16retrograde transport, vesicle recycling within Golgi (GO:0000301)2.87290139
17embryonic retina morphogenesis in camera-type eye (GO:0060059)2.87038984
18regulation of cell communication by electrical coupling (GO:0010649)2.85851801
19presynaptic membrane organization (GO:0097090)2.85120011
20establishment of protein localization to Golgi (GO:0072600)2.84017647
21protein targeting to Golgi (GO:0000042)2.83858856
22regulation of synaptic vesicle exocytosis (GO:2000300)2.82071566
23phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.80850931
24detection of calcium ion (GO:0005513)2.80640606
25negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.80574179
26muscle filament sliding (GO:0030049)2.77456312
27actin-myosin filament sliding (GO:0033275)2.77456312
28regulation of dendritic spine development (GO:0060998)2.67376357
29pyrimidine nucleobase catabolic process (GO:0006208)2.66023187
30positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.65359928
31cardiac muscle hypertrophy (GO:0003300)2.64745806
32cardiac myofibril assembly (GO:0055003)2.63889583
33cell communication involved in cardiac conduction (GO:0086065)2.62308768
34locomotory exploration behavior (GO:0035641)2.61566791
35axonal fasciculation (GO:0007413)2.57093785
36cerebral cortex radially oriented cell migration (GO:0021799)2.55891814
37actin-mediated cell contraction (GO:0070252)2.53908518
38synaptic vesicle maturation (GO:0016188)2.51754874
39cell communication by electrical coupling (GO:0010644)2.51715401
40negative regulation of neurotransmitter secretion (GO:0046929)2.51507039
41cardiac muscle contraction (GO:0060048)2.51397005
42striated muscle hypertrophy (GO:0014897)2.49262352
43regulation of dendritic spine morphogenesis (GO:0061001)2.49008328
44interkinetic nuclear migration (GO:0022027)2.48573641
45regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.47845870
46relaxation of cardiac muscle (GO:0055119)2.47107595
47actin filament-based movement (GO:0030048)2.45903671
48negative regulation of potassium ion transmembrane transport (GO:1901380)2.45716629
49striated muscle contraction (GO:0006941)2.43111776
50regulation of cardiac muscle cell contraction (GO:0086004)2.41921958
51response to inactivity (GO:0014854)2.41793718
52central nervous system projection neuron axonogenesis (GO:0021952)2.40114313
53negative regulation of neurotransmitter transport (GO:0051589)2.40035589
54apical protein localization (GO:0045176)2.40025883
55regulation of protein glycosylation (GO:0060049)2.39971073
56nucleobase catabolic process (GO:0046113)2.39680610
57vesicle transport along microtubule (GO:0047496)2.38593396
58negative regulation of cytosolic calcium ion concentration (GO:0051481)2.38408192
59regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.37654719
60neuronal action potential propagation (GO:0019227)2.36831877
61negative regulation of dendrite morphogenesis (GO:0050774)2.35058983
62negative regulation of dendrite development (GO:2000171)2.35031924
63import into cell (GO:0098657)2.33985286
64sarcomere organization (GO:0045214)2.33881760
65neuron recognition (GO:0008038)2.33124329
66ionotropic glutamate receptor signaling pathway (GO:0035235)2.32797285
67regulation of synaptic vesicle transport (GO:1902803)2.30318006
68central nervous system neuron axonogenesis (GO:0021955)2.30061418
69dendritic spine morphogenesis (GO:0060997)2.27433117
70Golgi to endosome transport (GO:0006895)2.27015957
71carnitine shuttle (GO:0006853)2.26582007
72response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.26070944
73suckling behavior (GO:0001967)2.24638692
74carnitine transport (GO:0015879)2.24009219
75amino-acid betaine transport (GO:0015838)2.24009219
76actomyosin structure organization (GO:0031032)2.23895239
77carnitine transmembrane transport (GO:1902603)2.23367924
78mitotic sister chromatid cohesion (GO:0007064)2.23278180
79regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.22846797
80positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.21207593
81negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.18521241
82dendrite morphogenesis (GO:0048813)2.18195820
83positive regulation of macroautophagy (GO:0016239)2.17158133
84monoubiquitinated protein deubiquitination (GO:0035520)2.16377272
85cardiac muscle adaptation (GO:0014887)2.15980414
86cardiac muscle hypertrophy in response to stress (GO:0014898)2.15980414
87muscle hypertrophy in response to stress (GO:0003299)2.15980414
88postsynaptic membrane organization (GO:0001941)2.14213023
89regulation of ARF protein signal transduction (GO:0032012)2.13151117
90regulation of skeletal muscle cell differentiation (GO:2001014)2.12376829
91epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.11661337
92regulation of Rac protein signal transduction (GO:0035020)2.11609970
93regulation of clathrin-mediated endocytosis (GO:2000369)2.11242248
94histone H3-K9 demethylation (GO:0033169)2.10292846
95positive regulation of dendritic spine development (GO:0060999)2.10100854
96regulation of Rap GTPase activity (GO:0032317)2.09841714
97response to epinephrine (GO:0071871)2.08923311
98cerebellar granule cell differentiation (GO:0021707)2.08481996
99vocalization behavior (GO:0071625)2.08247450
100positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.07983320

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.04864048
2CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.89287387
3CDX2_19796622_ChIP-Seq_MESCs_Mouse2.56058180
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28209614
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.18236501
6TAF15_26573619_Chip-Seq_HEK293_Human2.12246680
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.10673284
8SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.09959212
9EZH2_22144423_ChIP-Seq_EOC_Human2.03716815
10ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99461250
11AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.98788960
12RBPJ_22232070_ChIP-Seq_NCS_Mouse1.92800737
13SMAD_19615063_ChIP-ChIP_OVARY_Human1.90467826
14SMAD4_21799915_ChIP-Seq_A2780_Human1.88612715
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86585238
16PIAS1_25552417_ChIP-Seq_VCAP_Human1.84428792
17SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.83170538
18ZNF217_24962896_ChIP-Seq_MCF-7_Human1.81191701
19PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79234583
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76548907
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72546106
22OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71729287
23MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.70486559
24EP300_21415370_ChIP-Seq_HL-1_Mouse1.70252320
25P300_19829295_ChIP-Seq_ESCs_Human1.57418208
26SMAD3_21741376_ChIP-Seq_EPCs_Human1.52867995
27BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.51538848
28* STAT3_23295773_ChIP-Seq_U87_Human1.49375718
29SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48104751
30TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45658958
31* TCF4_23295773_ChIP-Seq_U87_Human1.42043605
32IGF1R_20145208_ChIP-Seq_DFB_Human1.41807682
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40795002
34TP53_16413492_ChIP-PET_HCT116_Human1.39774348
35FUS_26573619_Chip-Seq_HEK293_Human1.38885509
36TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.37868721
37AHR_22903824_ChIP-Seq_MCF-7_Human1.36612607
38ESR1_20079471_ChIP-ChIP_T-47D_Human1.36575314
39BCAT_22108803_ChIP-Seq_LS180_Human1.36443038
40WT1_19549856_ChIP-ChIP_CCG9911_Human1.36147565
41TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34882805
42NANOG_18555785_Chip-Seq_ESCs_Mouse1.34674202
43ARNT_22903824_ChIP-Seq_MCF-7_Human1.33386683
44NRF2_20460467_ChIP-Seq_MEFs_Mouse1.33195954
45NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.33195954
46ER_23166858_ChIP-Seq_MCF-7_Human1.33054732
47NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32847741
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32571091
49TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32571091
50CTNNB1_20460455_ChIP-Seq_HCT116_Human1.30987560
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30688703
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29537798
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.26399392
54SMAD3_21741376_ChIP-Seq_HESCs_Human1.25267497
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25213178
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23974584
57YAP1_20516196_ChIP-Seq_MESCs_Mouse1.22874904
58LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22743690
59FOXM1_26456572_ChIP-Seq_MCF-7_Human1.22699767
60SOX2_21211035_ChIP-Seq_LN229_Gbm1.22425258
61AR_25329375_ChIP-Seq_VCAP_Human1.20802717
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19631524
63FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19573318
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18770341
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18700953
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.17534002
67E2F1_18555785_Chip-Seq_ESCs_Mouse1.16569899
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15727983
69STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13759486
70AR_21572438_ChIP-Seq_LNCaP_Human1.13452369
71WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13210646
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.12575535
73RUNX2_22187159_ChIP-Seq_PCA_Human1.11217640
74SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11028806
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10731803
76REST_21632747_ChIP-Seq_MESCs_Mouse1.10328124
77P53_22387025_ChIP-Seq_ESCs_Mouse1.10266008
78CMYC_18555785_Chip-Seq_ESCs_Mouse1.09891931
79DROSHA_22980978_ChIP-Seq_HELA_Human1.09533693
80SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07958112
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07244435
82* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06710016
83* CBP_20019798_ChIP-Seq_JUKART_Human1.06710016
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05988317
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.05886255
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05823383
87* SMAD4_21741376_ChIP-Seq_HESCs_Human1.05121984
88CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03707990
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02823038
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.02473830
91Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02403143
92CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.00482143
93TCF4_18268006_ChIP-ChIP_LS174T_Human1.00409333
94JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00390114
95CBX2_27304074_Chip-Seq_ESCs_Mouse1.00216788
96KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.97847016
97EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97514908
98TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97177533
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96520786
100AR_19668381_ChIP-Seq_PC3_Human0.96356560

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.71832347
2MP0004270_analgesia3.36319970
3MP0005248_abnormal_Harderian_gland2.75834890
4MP0004859_abnormal_synaptic_plasticity2.72242046
5MP0003787_abnormal_imprinting2.47939909
6MP0003656_abnormal_erythrocyte_physiolo2.42568088
7MP0004215_abnormal_myocardial_fiber2.36846451
8MP0004084_abnormal_cardiac_muscle2.20295865
9MP0004484_altered_response_of2.17420350
10MP0004036_abnormal_muscle_relaxation2.02999700
11MP0000749_muscle_degeneration2.02145944
12MP0004145_abnormal_muscle_electrophysio2.01514044
13MP0009780_abnormal_chondrocyte_physiolo2.00999033
14MP0004130_abnormal_muscle_cell1.94752159
15MP0001486_abnormal_startle_reflex1.93992230
16MP0003880_abnormal_central_pattern1.91758349
17MP0002909_abnormal_adrenal_gland1.89971739
18MP0002822_catalepsy1.89923910
19MP0000751_myopathy1.89633008
20MP0005409_darkened_coat_color1.88798987
21MP0002837_dystrophic_cardiac_calcinosis1.85008687
22MP0000778_abnormal_nervous_system1.80297100
23MP0003635_abnormal_synaptic_transmissio1.79501754
24MP0003646_muscle_fatigue1.76850955
25MP0008877_abnormal_DNA_methylation1.71095293
26MP0003122_maternal_imprinting1.71084177
27MP0002734_abnormal_mechanical_nocicepti1.70419678
28MP0004147_increased_porphyrin_level1.69689695
29MP0003890_abnormal_embryonic-extraembry1.64985632
30MP0005620_abnormal_muscle_contractility1.64762606
31MP0002972_abnormal_cardiac_muscle1.64177685
32MP0005386_behavior/neurological_phenoty1.59973415
33MP0004924_abnormal_behavior1.59973415
34MP0003690_abnormal_glial_cell1.54914874
35MP0002272_abnormal_nervous_system1.47244177
36MP0002063_abnormal_learning/memory/cond1.45908276
37MP0001984_abnormal_olfaction1.42285293
38MP0002064_seizures1.39331958
39MP0002127_abnormal_cardiovascular_syste1.39163561
40MP0003329_amyloid_beta_deposits1.36526791
41MP0004510_myositis1.36494789
42MP0003632_abnormal_nervous_system1.34123116
43MP0010678_abnormal_skin_adnexa1.32278213
44MP0000427_abnormal_hair_cycle1.31926279
45MP0009745_abnormal_behavioral_response1.30970095
46MP0004087_abnormal_muscle_fiber1.30327012
47MP0002638_abnormal_pupillary_reflex1.29109296
48MP0005187_abnormal_penis_morphology1.28944034
49MP0002106_abnormal_muscle_physiology1.25496315
50MP0004085_abnormal_heartbeat1.22035125
51MP0003633_abnormal_nervous_system1.21796837
52MP0010234_abnormal_vibrissa_follicle1.21496907
53MP0003045_fibrosis1.20364254
54MP0000747_muscle_weakness1.19725166
55MP0002971_abnormal_brown_adipose1.18738731
56MP0002269_muscular_atrophy1.16684604
57MP0002067_abnormal_sensory_capabilities1.16384752
58MP0000383_abnormal_hair_follicle1.15555756
59MP0003631_nervous_system_phenotype1.15416806
60MP0003221_abnormal_cardiomyocyte_apopto1.15063945
61MP0003121_genomic_imprinting1.13277752
62MP0004811_abnormal_neuron_physiology1.12934437
63MP0000955_abnormal_spinal_cord1.12692859
64MP0009046_muscle_twitch1.12261951
65MP0003195_calcinosis1.11167966
66MP0001440_abnormal_grooming_behavior1.09883271
67MP0005423_abnormal_somatic_nervous1.09586395
68MP0003828_pulmonary_edema1.07188317
69MP0004885_abnormal_endolymph1.04310984
70MP0010630_abnormal_cardiac_muscle1.01218662
71MP0003137_abnormal_impulse_conducting1.00984386
72MP0009703_decreased_birth_body1.00686891
73MP0002572_abnormal_emotion/affect_behav1.00506749
74MP0005369_muscle_phenotype0.98299255
75MP0002168_other_aberrant_phenotype0.97244082
76MP0000604_amyloidosis0.96925937
77MP0002332_abnormal_exercise_endurance0.92225783
78MP0002102_abnormal_ear_morphology0.92098112
79MP0002882_abnormal_neuron_morphology0.91102194
80MP0005330_cardiomyopathy0.89662411
81MP0001501_abnormal_sleep_pattern0.89051791
82MP0002735_abnormal_chemical_nociception0.88506185
83MP0003183_abnormal_peptide_metabolism0.88352836
84MP0005253_abnormal_eye_physiology0.88304433
85MP0006138_congestive_heart_failure0.87879210
86MP0002229_neurodegeneration0.87467600
87MP0002066_abnormal_motor_capabilities/c0.84647604
88MP0003172_abnormal_lysosome_physiology0.81102323
89MP0002152_abnormal_brain_morphology0.80841078
90MP0003634_abnormal_glial_cell0.79801113
91MP0006276_abnormal_autonomic_nervous0.79486767
92MP0008569_lethality_at_weaning0.78285860
93MP0001177_atelectasis0.76237656
94MP0002184_abnormal_innervation0.75356666
95MP0000920_abnormal_myelination0.74227415
96MP0002557_abnormal_social/conspecific_i0.74043420
97MP0001544_abnormal_cardiovascular_syste0.73254084
98MP0005385_cardiovascular_system_phenoty0.73254084
99MP0003879_abnormal_hair_cell0.73087879
100MP0001502_abnormal_circadian_rhythm0.72850292

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)4.78253268
2Difficulty running (HP:0009046)3.64099178
3Hyporeflexia of lower limbs (HP:0002600)3.27530157
4Febrile seizures (HP:0002373)3.22446152
5Bundle branch block (HP:0011710)3.18571311
6Muscle fiber inclusion bodies (HP:0100299)3.13213704
7Muscle fiber splitting (HP:0003555)3.09594389
8Abnormality of the calf musculature (HP:0001430)2.99924418
9Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.96818499
10Thyroid carcinoma (HP:0002890)2.96127109
11Nemaline bodies (HP:0003798)2.92600616
12Calf muscle hypertrophy (HP:0008981)2.89860097
13Subaortic stenosis (HP:0001682)2.88075740
14Abnormality of the left ventricular outflow tract (HP:0011103)2.88075740
15Muscle hypertrophy of the lower extremities (HP:0008968)2.87140144
16Sudden death (HP:0001699)2.71335778
17Atonic seizures (HP:0010819)2.68019115
18Hepatoblastoma (HP:0002884)2.67011390
19Focal motor seizures (HP:0011153)2.61519835
20Exercise-induced myalgia (HP:0003738)2.59629250
21Exercise-induced muscle cramps (HP:0003710)2.59381564
22Rimmed vacuoles (HP:0003805)2.54891676
23Focal seizures (HP:0007359)2.52470027
24Drooling (HP:0002307)2.52176544
25Frequent falls (HP:0002359)2.51694618
26Hyperkalemia (HP:0002153)2.48826626
27Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.46746178
28Hyperventilation (HP:0002883)2.46533851
29Syncope (HP:0001279)2.41641195
30Excessive salivation (HP:0003781)2.41199081
31EMG: myopathic abnormalities (HP:0003458)2.37225276
32Action tremor (HP:0002345)2.36241160
33Hypochromic microcytic anemia (HP:0004840)2.31922039
34Curly hair (HP:0002212)2.28335061
35Abnormality of the lower motor neuron (HP:0002366)2.25286671
36Rhinitis (HP:0012384)2.19675731
37EMG: neuropathic changes (HP:0003445)2.19394336
38Volvulus (HP:0002580)2.18708410
39Absent speech (HP:0001344)2.18115293
40Abnormality of the corticospinal tract (HP:0002492)2.17899155
41Type 1 muscle fiber predominance (HP:0003803)2.14355805
42Amyotrophic lateral sclerosis (HP:0007354)2.10610409
43Fetal akinesia sequence (HP:0001989)2.07135922
44Absent/shortened dynein arms (HP:0200106)2.06410133
45Dynein arm defect of respiratory motile cilia (HP:0012255)2.06410133
46Abnormal ciliary motility (HP:0012262)2.05222910
47Truncal obesity (HP:0001956)2.03804990
48Dialeptic seizures (HP:0011146)2.01612004
49Resting tremor (HP:0002322)2.00460998
50Impaired vibration sensation in the lower limbs (HP:0002166)2.00108632
51Postural instability (HP:0002172)1.98696775
52Aqueductal stenosis (HP:0002410)1.97930772
53Lower limb muscle weakness (HP:0007340)1.97205197
54Abnormal respiratory motile cilium physiology (HP:0012261)1.96923232
55Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.95544286
56Degeneration of the lateral corticospinal tracts (HP:0002314)1.95544286
57Ventricular fibrillation (HP:0001663)1.95514375
58Inappropriate behavior (HP:0000719)1.93678519
59Gaze-evoked nystagmus (HP:0000640)1.91946013
60Abnormal respiratory epithelium morphology (HP:0012253)1.91852708
61Abnormal respiratory motile cilium morphology (HP:0005938)1.91852708
62Abnormality of the ischium (HP:0003174)1.91060446
63Urinary bladder sphincter dysfunction (HP:0002839)1.90725571
64Atrial fibrillation (HP:0005110)1.90266195
65Asymmetric septal hypertrophy (HP:0001670)1.89975022
66Subacute progressive viral hepatitis (HP:0006572)1.87999912
67Impaired vibratory sensation (HP:0002495)1.86773873
68Exotropia (HP:0000577)1.84465795
69Macroorchidism (HP:0000053)1.83061156
70Pheochromocytoma (HP:0002666)1.82891360
71Ventricular arrhythmia (HP:0004308)1.82738412
72Heterotopia (HP:0002282)1.81141542
73Hyperinsulinemic hypoglycemia (HP:0000825)1.81022538
74Hip dysplasia (HP:0001385)1.78508758
75Spastic gait (HP:0002064)1.76385259
76Dysdiadochokinesis (HP:0002075)1.74556520
77Protruding tongue (HP:0010808)1.74157293
78Thickened helices (HP:0000391)1.72644143
79Proximal amyotrophy (HP:0007126)1.72161747
80Epileptic encephalopathy (HP:0200134)1.71838701
81Urinary urgency (HP:0000012)1.71623444
82Broad-based gait (HP:0002136)1.71262694
83Menstrual irregularities (HP:0000858)1.71219850
84Oligodactyly (hands) (HP:0001180)1.71037574
85Absence seizures (HP:0002121)1.70444089
86Lower limb asymmetry (HP:0100559)1.70132402
87Cystic hygroma (HP:0000476)1.68389358
88Intestinal atresia (HP:0011100)1.67970656
89Germ cell neoplasia (HP:0100728)1.67352531
90Osteomalacia (HP:0002749)1.65316127
91Chronic hepatic failure (HP:0100626)1.64687084
92Primary atrial arrhythmia (HP:0001692)1.63498265
93Abnormal EKG (HP:0003115)1.62635603
94Ankle clonus (HP:0011448)1.62446492
95Long clavicles (HP:0000890)1.61059297
96Transitional cell carcinoma of the bladder (HP:0006740)1.60040959
97Fair hair (HP:0002286)1.59623646
98Vertebral arch anomaly (HP:0008438)1.58562106
99Heart block (HP:0012722)1.58326868
100Childhood onset (HP:0011463)1.57756473

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN3.15029177
2MARK13.01827928
3CASK2.84710334
4PNCK2.45240461
5SGK22.45045661
6TNIK2.38785318
7AKT32.33351886
8FRK2.23690679
9SGK32.02897462
10CAMK1G2.01990953
11NTRK32.01379475
12DMPK1.91057376
13EPHA41.90654211
14NLK1.89672538
15ACVR1B1.86619350
16SGK4941.71709472
17SGK2231.71709472
18MAP3K41.66533141
19MAP3K21.62830576
20PAK31.58445233
21PHKG11.57000379
22PHKG21.57000379
23KSR11.55839363
24MAP2K41.49146618
25YES11.48212065
26EPHA31.45179687
27PINK11.44535900
28WNK31.38860873
29DAPK21.37244552
30BRD41.35308800
31MAPK131.29021329
32FGFR31.28464661
33FGFR21.27100875
34WNK11.23703717
35STK38L1.19878213
36CAMK1D1.19521123
37KSR21.10164016
38STK111.09517773
39ERBB31.09198694
40MAP3K71.06641209
41PLK20.91732900
42SGK10.89700696
43STK380.87712809
44PIK3CG0.86660460
45UHMK10.86048869
46PRKAA20.82210146
47TTN0.82087590
48STK240.80090064
49DYRK1A0.79706137
50TAOK10.79123265
51MAP3K90.78843035
52RAF10.77978665
53PTK2B0.75847261
54NTRK20.75285445
55PAK60.74723212
56MARK20.74306684
57RET0.73126927
58CAMK40.71908494
59ROCK20.71373404
60LATS10.69861049
61CDK50.69831352
62EPHB10.66992341
63MINK10.66504004
64IRAK10.64461579
65CAMK10.62872032
66RPS6KB10.62566269
67PRKAA10.61157165
68FGR0.60317176
69PRKG10.56928644
70FER0.56882333
71BCR0.56811091
72MAP3K50.55615893
73TRPM70.55086229
74MAP3K60.55043121
75PRKCE0.54972571
76PRKCH0.54344014
77PIK3CA0.53749101
78ROCK10.53546827
79PDGFRB0.51612111
80MAP3K10.50328110
81MAPK100.49811528
82MAP2K70.47043172
83NEK90.45819093
84MKNK20.44451406
85CAMK2A0.44250362
86OXSR10.44012148
87IRAK20.42613994
88CAMK2D0.42149859
89PRKCZ0.40099177
90CAMKK20.40037253
91PRKD30.39052011
92JAK20.38707572
93FGFR10.37019565
94STK390.36534701
95MAP2K10.36025797
96PRKCG0.35850880
97RIPK40.35567296
98STK30.34296863
99TRIM280.33324743
100BMPR1B0.32774644

Predicted pathways (KEGG)

RankGene SetZ-score
1Circadian rhythm_Homo sapiens_hsa047101.88480306
2Dorso-ventral axis formation_Homo sapiens_hsa043201.76597412
3Long-term potentiation_Homo sapiens_hsa047201.64988473
4Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64296884
5Insulin secretion_Homo sapiens_hsa049111.58529326
6Nicotine addiction_Homo sapiens_hsa050331.52781418
7Dilated cardiomyopathy_Homo sapiens_hsa054141.46464583
8Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45044923
9Phosphatidylinositol signaling system_Homo sapiens_hsa040701.42468391
10Circadian entrainment_Homo sapiens_hsa047131.41410674
11Long-term depression_Homo sapiens_hsa047301.38546882
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.38026984
13Inositol phosphate metabolism_Homo sapiens_hsa005621.30920187
14Endometrial cancer_Homo sapiens_hsa052131.30292658
15Amphetamine addiction_Homo sapiens_hsa050311.25979564
16cGMP-PKG signaling pathway_Homo sapiens_hsa040221.25674777
17Dopaminergic synapse_Homo sapiens_hsa047281.25522402
18Renin secretion_Homo sapiens_hsa049241.24419090
19Type II diabetes mellitus_Homo sapiens_hsa049301.24315801
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.20932558
21cAMP signaling pathway_Homo sapiens_hsa040241.19868635
22Oxytocin signaling pathway_Homo sapiens_hsa049211.18495166
23Glutamatergic synapse_Homo sapiens_hsa047241.17386061
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16939840
25Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.13015086
26Thyroid hormone signaling pathway_Homo sapiens_hsa049191.11979335
27FoxO signaling pathway_Homo sapiens_hsa040681.11388287
28Cholinergic synapse_Homo sapiens_hsa047251.09617629
29mTOR signaling pathway_Homo sapiens_hsa041501.09384261
30GnRH signaling pathway_Homo sapiens_hsa049121.07551582
31GABAergic synapse_Homo sapiens_hsa047271.06493498
32Gastric acid secretion_Homo sapiens_hsa049711.04318621
33Glucagon signaling pathway_Homo sapiens_hsa049221.00726906
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.00011473
35Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99922680
36Insulin signaling pathway_Homo sapiens_hsa049100.99307294
37Glioma_Homo sapiens_hsa052140.98695095
38Cocaine addiction_Homo sapiens_hsa050300.98366167
39Renal cell carcinoma_Homo sapiens_hsa052110.95730952
40Adherens junction_Homo sapiens_hsa045200.95476060
41Choline metabolism in cancer_Homo sapiens_hsa052310.94562950
42Salivary secretion_Homo sapiens_hsa049700.94257848
43Insulin resistance_Homo sapiens_hsa049310.93467580
44Tight junction_Homo sapiens_hsa045300.93394211
45Prolactin signaling pathway_Homo sapiens_hsa049170.92785869
46Estrogen signaling pathway_Homo sapiens_hsa049150.91990688
47Synaptic vesicle cycle_Homo sapiens_hsa047210.91946034
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91544008
49AMPK signaling pathway_Homo sapiens_hsa041520.91221307
50Regulation of autophagy_Homo sapiens_hsa041400.90194422
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89991628
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89965457
53ErbB signaling pathway_Homo sapiens_hsa040120.88181693
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87464423
55Calcium signaling pathway_Homo sapiens_hsa040200.86987097
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85161115
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83481149
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.83319841
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.82898398
60Morphine addiction_Homo sapiens_hsa050320.82428475
61Axon guidance_Homo sapiens_hsa043600.82197199
62Gap junction_Homo sapiens_hsa045400.81306956
63Non-small cell lung cancer_Homo sapiens_hsa052230.80675426
64Melanogenesis_Homo sapiens_hsa049160.79369922
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.75534793
66Serotonergic synapse_Homo sapiens_hsa047260.74753746
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.74601900
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74502751
69Prostate cancer_Homo sapiens_hsa052150.73260775
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72806201
71Propanoate metabolism_Homo sapiens_hsa006400.70984758
72Colorectal cancer_Homo sapiens_hsa052100.70142941
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.67601332
74Thyroid hormone synthesis_Homo sapiens_hsa049180.67021341
75Fatty acid biosynthesis_Homo sapiens_hsa000610.66266299
76Rap1 signaling pathway_Homo sapiens_hsa040150.66169966
77Fatty acid degradation_Homo sapiens_hsa000710.63912469
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63588152
79PPAR signaling pathway_Homo sapiens_hsa033200.62777890
80Bile secretion_Homo sapiens_hsa049760.61068955
81Histidine metabolism_Homo sapiens_hsa003400.60643968
82Wnt signaling pathway_Homo sapiens_hsa043100.59849036
83Pancreatic secretion_Homo sapiens_hsa049720.58595961
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58443809
85Lysine degradation_Homo sapiens_hsa003100.57728162
86MAPK signaling pathway_Homo sapiens_hsa040100.57010737
87Hedgehog signaling pathway_Homo sapiens_hsa043400.56938581
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56790796
89Fatty acid metabolism_Homo sapiens_hsa012120.55501056
90Proteoglycans in cancer_Homo sapiens_hsa052050.54307340
91Amoebiasis_Homo sapiens_hsa051460.53990498
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53151406
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53021644
94beta-Alanine metabolism_Homo sapiens_hsa004100.51732684
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.51667384
96Butanoate metabolism_Homo sapiens_hsa006500.51570796
97Platelet activation_Homo sapiens_hsa046110.51458042
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50090192
99Ras signaling pathway_Homo sapiens_hsa040140.50044659
100Pancreatic cancer_Homo sapiens_hsa052120.49162808

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