ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sarcoplasmic reticulum calcium ion transport (GO:0070296)	3.54855344
2	macroautophagy (GO:0016236)	3.44147054
3	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	3.40122008
4	nerve growth factor signaling pathway (GO:0038180)	3.36420196
5	establishment of nucleus localization (GO:0040023)	3.25968740
6	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	3.23353622
7	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	3.21050281
8	presynaptic membrane assembly (GO:0097105)	3.18804638
9	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.15739221
10	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	3.13245913
11	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	3.04806594
12	nucleus localization (GO:0051647)	3.02126145
13	regulation of relaxation of muscle (GO:1901077)	3.01503811
14	myofibril assembly (GO:0030239)	3.00099491
15	regulation of actin filament-based movement (GO:1903115)	2.88110493
16	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.87290139
17	embryonic retina morphogenesis in camera-type eye (GO:0060059)	2.87038984
18	regulation of cell communication by electrical coupling (GO:0010649)	2.85851801
19	presynaptic membrane organization (GO:0097090)	2.85120011
20	establishment of protein localization to Golgi (GO:0072600)	2.84017647
21	protein targeting to Golgi (GO:0000042)	2.83858856
22	regulation of synaptic vesicle exocytosis (GO:2000300)	2.82071566
23	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.80850931
24	detection of calcium ion (GO:0005513)	2.80640606
25	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	2.80574179
26	actin-myosin filament sliding (GO:0033275)	2.77456312
27	muscle filament sliding (GO:0030049)	2.77456312
28	regulation of dendritic spine development (GO:0060998)	2.67376357
29	pyrimidine nucleobase catabolic process (GO:0006208)	2.66023187
30	positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	2.65359928
31	cardiac muscle hypertrophy (GO:0003300)	2.64745806
32	cardiac myofibril assembly (GO:0055003)	2.63889583
33	cell communication involved in cardiac conduction (GO:0086065)	2.62308768
34	locomotory exploration behavior (GO:0035641)	2.61566791
35	axonal fasciculation (GO:0007413)	2.57093785
36	cerebral cortex radially oriented cell migration (GO:0021799)	2.55891814
37	actin-mediated cell contraction (GO:0070252)	2.53908518
38	synaptic vesicle maturation (GO:0016188)	2.51754874
39	cell communication by electrical coupling (GO:0010644)	2.51715401
40	negative regulation of neurotransmitter secretion (GO:0046929)	2.51507039
41	cardiac muscle contraction (GO:0060048)	2.51397005
42	striated muscle hypertrophy (GO:0014897)	2.49262352
43	regulation of dendritic spine morphogenesis (GO:0061001)	2.49008328
44	interkinetic nuclear migration (GO:0022027)	2.48573641
45	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.47845870
46	relaxation of cardiac muscle (GO:0055119)	2.47107595
47	actin filament-based movement (GO:0030048)	2.45903671
48	negative regulation of potassium ion transmembrane transport (GO:1901380)	2.45716629
49	striated muscle contraction (GO:0006941)	2.43111776
50	regulation of cardiac muscle cell contraction (GO:0086004)	2.41921958
51	response to inactivity (GO:0014854)	2.41793718
52	central nervous system projection neuron axonogenesis (GO:0021952)	2.40114313
53	negative regulation of neurotransmitter transport (GO:0051589)	2.40035589
54	apical protein localization (GO:0045176)	2.40025883
55	regulation of protein glycosylation (GO:0060049)	2.39971073
56	nucleobase catabolic process (GO:0046113)	2.39680610
57	vesicle transport along microtubule (GO:0047496)	2.38593396
58	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.38408192
59	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.37654719
60	neuronal action potential propagation (GO:0019227)	2.36831877
61	negative regulation of dendrite morphogenesis (GO:0050774)	2.35058983
62	negative regulation of dendrite development (GO:2000171)	2.35031924
63	import into cell (GO:0098657)	2.33985286
64	sarcomere organization (GO:0045214)	2.33881760
65	neuron recognition (GO:0008038)	2.33124329
66	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.32797285
67	regulation of synaptic vesicle transport (GO:1902803)	2.30318006
68	central nervous system neuron axonogenesis (GO:0021955)	2.30061418
69	dendritic spine morphogenesis (GO:0060997)	2.27433117
70	Golgi to endosome transport (GO:0006895)	2.27015957
71	carnitine shuttle (GO:0006853)	2.26582007
72	response to stimulus involved in regulation of muscle adaptation (GO:0014874)	2.26070944
73	suckling behavior (GO:0001967)	2.24638692
74	amino-acid betaine transport (GO:0015838)	2.24009219
75	carnitine transport (GO:0015879)	2.24009219
76	actomyosin structure organization (GO:0031032)	2.23895239
77	carnitine transmembrane transport (GO:1902603)	2.23367924
78	mitotic sister chromatid cohesion (GO:0007064)	2.23278180
79	regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	2.22846797
80	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.21207593
81	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	2.18521241
82	dendrite morphogenesis (GO:0048813)	2.18195820
83	positive regulation of macroautophagy (GO:0016239)	2.17158133
84	monoubiquitinated protein deubiquitination (GO:0035520)	2.16377272
85	cardiac muscle hypertrophy in response to stress (GO:0014898)	2.15980414
86	muscle hypertrophy in response to stress (GO:0003299)	2.15980414
87	cardiac muscle adaptation (GO:0014887)	2.15980414
88	postsynaptic membrane organization (GO:0001941)	2.14213023
89	regulation of ARF protein signal transduction (GO:0032012)	2.13151117
90	regulation of skeletal muscle cell differentiation (GO:2001014)	2.12376829
91	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.11661337
92	regulation of Rac protein signal transduction (GO:0035020)	2.11609970
93	regulation of clathrin-mediated endocytosis (GO:2000369)	2.11242248
94	histone H3-K9 demethylation (GO:0033169)	2.10292846
95	positive regulation of dendritic spine development (GO:0060999)	2.10100854
96	regulation of Rap GTPase activity (GO:0032317)	2.09841714
97	response to epinephrine (GO:0071871)	2.08923311
98	cerebellar granule cell differentiation (GO:0021707)	2.08481996
99	vocalization behavior (GO:0071625)	2.08247450
100	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.07983320

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.04864048
2	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.89287387
3	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.56058180
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.28209614
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.18236501
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.12246680
7	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.10673284
8	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.09959212
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.03716815
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.99461250
11	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.98788960
12	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.92800737
13	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.90467826
14	SMAD4_21799915_ChIP-Seq_A2780_Human	1.88612715
15	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.86585238
16	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.84428792
17	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.83170538
18	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.81191701
19	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.79234583
20	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.76548907
21	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.72546106
22	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.71729287
23	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.70486559
24	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.70252320
25	P300_19829295_ChIP-Seq_ESCs_Human	1.57418208
26	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.52867995
27	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.51538848
28	* STAT3_23295773_ChIP-Seq_U87_Human	1.49375718
29	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.48104751
30	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.45658958
31	* TCF4_23295773_ChIP-Seq_U87_Human	1.42043605
32	IGF1R_20145208_ChIP-Seq_DFB_Human	1.41807682
33	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.40795002
34	TP53_16413492_ChIP-PET_HCT116_Human	1.39774348
35	FUS_26573619_Chip-Seq_HEK293_Human	1.38885509
36	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.37868721
37	AHR_22903824_ChIP-Seq_MCF-7_Human	1.36612607
38	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.36575314
39	BCAT_22108803_ChIP-Seq_LS180_Human	1.36443038
40	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.36147565
41	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.34882805
42	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.34674202
43	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.33386683
44	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.33195954
45	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.33195954
46	ER_23166858_ChIP-Seq_MCF-7_Human	1.33054732
47	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.32847741
48	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32571091
49	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.32571091
50	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.30987560
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.30688703
52	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.29537798
53	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.26399392
54	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.25267497
55	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.25213178
56	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.23974584
57	YAP1_20516196_ChIP-Seq_MESCs_Mouse	1.22874904
58	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.22743690
59	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.22699767
60	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.22425258
61	AR_25329375_ChIP-Seq_VCAP_Human	1.20802717
62	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.19631524
63	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.19573318
64	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.18770341
65	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.18700953
66	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.17534002
67	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.16569899
68	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.15727983
69	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.13759486
70	AR_21572438_ChIP-Seq_LNCaP_Human	1.13452369
71	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.13210646
72	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.12575535
73	RUNX2_22187159_ChIP-Seq_PCA_Human	1.11217640
74	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.11028806
75	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.10731803
76	REST_21632747_ChIP-Seq_MESCs_Mouse	1.10328124
77	P53_22387025_ChIP-Seq_ESCs_Mouse	1.10266008
78	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.09891931
79	DROSHA_22980978_ChIP-Seq_HELA_Human	1.09533693
80	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.07958112
81	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.07244435
82	* CBP_20019798_ChIP-Seq_JUKART_Human	1.06710016
83	* IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.06710016
84	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05988317
85	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.05886255
86	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.05823383
87	* SMAD4_21741376_ChIP-Seq_HESCs_Human	1.05121984
88	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.03707990
89	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.02823038
90	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.02473830
91	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.02403143
92	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.00482143
93	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.00409333
94	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.00390114
95	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.00216788
96	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.97847016
97	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.97514908
98	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.97177533
99	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.96520786
100	AR_19668381_ChIP-Seq_PC3_Human	0.96356560

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.71832347
2	MP0004270_analgesia	3.36319970
3	MP0005248_abnormal_Harderian_gland	2.75834890
4	MP0004859_abnormal_synaptic_plasticity	2.72242046
5	MP0003787_abnormal_imprinting	2.47939909
6	MP0003656_abnormal_erythrocyte_physiolo	2.42568088
7	MP0004215_abnormal_myocardial_fiber	2.36846451
8	MP0004084_abnormal_cardiac_muscle	2.20295865
9	MP0004484_altered_response_of	2.17420350
10	MP0004036_abnormal_muscle_relaxation	2.02999700
11	MP0000749_muscle_degeneration	2.02145944
12	MP0004145_abnormal_muscle_electrophysio	2.01514044
13	MP0009780_abnormal_chondrocyte_physiolo	2.00999033
14	MP0004130_abnormal_muscle_cell	1.94752159
15	MP0001486_abnormal_startle_reflex	1.93992230
16	MP0003880_abnormal_central_pattern	1.91758349
17	MP0002909_abnormal_adrenal_gland	1.89971739
18	MP0002822_catalepsy	1.89923910
19	MP0000751_myopathy	1.89633008
20	MP0005409_darkened_coat_color	1.88798987
21	MP0002837_dystrophic_cardiac_calcinosis	1.85008687
22	MP0000778_abnormal_nervous_system	1.80297100
23	MP0003635_abnormal_synaptic_transmissio	1.79501754
24	MP0003646_muscle_fatigue	1.76850955
25	MP0008877_abnormal_DNA_methylation	1.71095293
26	MP0003122_maternal_imprinting	1.71084177
27	MP0002734_abnormal_mechanical_nocicepti	1.70419678
28	MP0004147_increased_porphyrin_level	1.69689695
29	MP0003890_abnormal_embryonic-extraembry	1.64985632
30	MP0005620_abnormal_muscle_contractility	1.64762606
31	MP0002972_abnormal_cardiac_muscle	1.64177685
32	MP0005386_behavior/neurological_phenoty	1.59973415
33	MP0004924_abnormal_behavior	1.59973415
34	MP0003690_abnormal_glial_cell	1.54914874
35	MP0002272_abnormal_nervous_system	1.47244177
36	MP0002063_abnormal_learning/memory/cond	1.45908276
37	MP0001984_abnormal_olfaction	1.42285293
38	MP0002064_seizures	1.39331958
39	MP0002127_abnormal_cardiovascular_syste	1.39163561
40	MP0003329_amyloid_beta_deposits	1.36526791
41	MP0004510_myositis	1.36494789
42	MP0003632_abnormal_nervous_system	1.34123116
43	MP0010678_abnormal_skin_adnexa	1.32278213
44	MP0000427_abnormal_hair_cycle	1.31926279
45	MP0009745_abnormal_behavioral_response	1.30970095
46	MP0004087_abnormal_muscle_fiber	1.30327012
47	MP0002638_abnormal_pupillary_reflex	1.29109296
48	MP0005187_abnormal_penis_morphology	1.28944034
49	MP0002106_abnormal_muscle_physiology	1.25496315
50	MP0004085_abnormal_heartbeat	1.22035125
51	MP0003633_abnormal_nervous_system	1.21796837
52	MP0010234_abnormal_vibrissa_follicle	1.21496907
53	MP0003045_fibrosis	1.20364254
54	MP0000747_muscle_weakness	1.19725166
55	MP0002971_abnormal_brown_adipose	1.18738731
56	MP0002269_muscular_atrophy	1.16684604
57	MP0002067_abnormal_sensory_capabilities	1.16384752
58	MP0000383_abnormal_hair_follicle	1.15555756
59	MP0003631_nervous_system_phenotype	1.15416806
60	MP0003221_abnormal_cardiomyocyte_apopto	1.15063945
61	MP0003121_genomic_imprinting	1.13277752
62	MP0004811_abnormal_neuron_physiology	1.12934437
63	MP0000955_abnormal_spinal_cord	1.12692859
64	MP0009046_muscle_twitch	1.12261951
65	MP0003195_calcinosis	1.11167966
66	MP0001440_abnormal_grooming_behavior	1.09883271
67	MP0005423_abnormal_somatic_nervous	1.09586395
68	MP0003828_pulmonary_edema	1.07188317
69	MP0004885_abnormal_endolymph	1.04310984
70	MP0010630_abnormal_cardiac_muscle	1.01218662
71	MP0003137_abnormal_impulse_conducting	1.00984386
72	MP0009703_decreased_birth_body	1.00686891
73	MP0002572_abnormal_emotion/affect_behav	1.00506749
74	MP0005369_muscle_phenotype	0.98299255
75	MP0002168_other_aberrant_phenotype	0.97244082
76	MP0000604_amyloidosis	0.96925937
77	MP0002332_abnormal_exercise_endurance	0.92225783
78	MP0002102_abnormal_ear_morphology	0.92098112
79	MP0002882_abnormal_neuron_morphology	0.91102194
80	MP0005330_cardiomyopathy	0.89662411
81	MP0001501_abnormal_sleep_pattern	0.89051791
82	MP0002735_abnormal_chemical_nociception	0.88506185
83	MP0003183_abnormal_peptide_metabolism	0.88352836
84	MP0005253_abnormal_eye_physiology	0.88304433
85	MP0006138_congestive_heart_failure	0.87879210
86	MP0002229_neurodegeneration	0.87467600
87	MP0002066_abnormal_motor_capabilities/c	0.84647604
88	MP0003172_abnormal_lysosome_physiology	0.81102323
89	MP0002152_abnormal_brain_morphology	0.80841078
90	MP0003634_abnormal_glial_cell	0.79801113
91	MP0006276_abnormal_autonomic_nervous	0.79486767
92	MP0008569_lethality_at_weaning	0.78285860
93	MP0001177_atelectasis	0.76237656
94	MP0002184_abnormal_innervation	0.75356666
95	MP0000920_abnormal_myelination	0.74227415
96	MP0002557_abnormal_social/conspecific_i	0.74043420
97	MP0001544_abnormal_cardiovascular_syste	0.73254084
98	MP0005385_cardiovascular_system_phenoty	0.73254084
99	MP0003879_abnormal_hair_cell	0.73087879
100	MP0001502_abnormal_circadian_rhythm	0.72850292

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Papillary thyroid carcinoma (HP:0002895)	4.78253268
2	Difficulty running (HP:0009046)	3.64099178
3	Hyporeflexia of lower limbs (HP:0002600)	3.27530157
4	Febrile seizures (HP:0002373)	3.22446152
5	Bundle branch block (HP:0011710)	3.18571311
6	Muscle fiber inclusion bodies (HP:0100299)	3.13213704
7	Muscle fiber splitting (HP:0003555)	3.09594389
8	Abnormality of the calf musculature (HP:0001430)	2.99924418
9	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	2.96818499
10	Thyroid carcinoma (HP:0002890)	2.96127109
11	Nemaline bodies (HP:0003798)	2.92600616
12	Calf muscle hypertrophy (HP:0008981)	2.89860097
13	Abnormality of the left ventricular outflow tract (HP:0011103)	2.88075740
14	Subaortic stenosis (HP:0001682)	2.88075740
15	Muscle hypertrophy of the lower extremities (HP:0008968)	2.87140144
16	Sudden death (HP:0001699)	2.71335778
17	Atonic seizures (HP:0010819)	2.68019115
18	Hepatoblastoma (HP:0002884)	2.67011390
19	Focal motor seizures (HP:0011153)	2.61519835
20	Exercise-induced myalgia (HP:0003738)	2.59629250
21	Exercise-induced muscle cramps (HP:0003710)	2.59381564
22	Rimmed vacuoles (HP:0003805)	2.54891676
23	Focal seizures (HP:0007359)	2.52470027
24	Drooling (HP:0002307)	2.52176544
25	Frequent falls (HP:0002359)	2.51694618
26	Hyperkalemia (HP:0002153)	2.48826626
27	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.46746178
28	Hyperventilation (HP:0002883)	2.46533851
29	Syncope (HP:0001279)	2.41641195
30	Excessive salivation (HP:0003781)	2.41199081
31	EMG: myopathic abnormalities (HP:0003458)	2.37225276
32	Action tremor (HP:0002345)	2.36241160
33	Hypochromic microcytic anemia (HP:0004840)	2.31922039
34	Curly hair (HP:0002212)	2.28335061
35	Abnormality of the lower motor neuron (HP:0002366)	2.25286671
36	Rhinitis (HP:0012384)	2.19675731
37	EMG: neuropathic changes (HP:0003445)	2.19394336
38	Volvulus (HP:0002580)	2.18708410
39	Absent speech (HP:0001344)	2.18115293
40	Abnormality of the corticospinal tract (HP:0002492)	2.17899155
41	Type 1 muscle fiber predominance (HP:0003803)	2.14355805
42	Amyotrophic lateral sclerosis (HP:0007354)	2.10610409
43	Fetal akinesia sequence (HP:0001989)	2.07135922
44	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.06410133
45	Absent/shortened dynein arms (HP:0200106)	2.06410133
46	Abnormal ciliary motility (HP:0012262)	2.05222910
47	Truncal obesity (HP:0001956)	2.03804990
48	Dialeptic seizures (HP:0011146)	2.01612004
49	Resting tremor (HP:0002322)	2.00460998
50	Impaired vibration sensation in the lower limbs (HP:0002166)	2.00108632
51	Postural instability (HP:0002172)	1.98696775
52	Aqueductal stenosis (HP:0002410)	1.97930772
53	Lower limb muscle weakness (HP:0007340)	1.97205197
54	Abnormal respiratory motile cilium physiology (HP:0012261)	1.96923232
55	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.95544286
56	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.95544286
57	Ventricular fibrillation (HP:0001663)	1.95514375
58	Inappropriate behavior (HP:0000719)	1.93678519
59	Gaze-evoked nystagmus (HP:0000640)	1.91946013
60	Abnormal respiratory epithelium morphology (HP:0012253)	1.91852708
61	Abnormal respiratory motile cilium morphology (HP:0005938)	1.91852708
62	Abnormality of the ischium (HP:0003174)	1.91060446
63	Urinary bladder sphincter dysfunction (HP:0002839)	1.90725571
64	Atrial fibrillation (HP:0005110)	1.90266195
65	Asymmetric septal hypertrophy (HP:0001670)	1.89975022
66	Subacute progressive viral hepatitis (HP:0006572)	1.87999912
67	Impaired vibratory sensation (HP:0002495)	1.86773873
68	Exotropia (HP:0000577)	1.84465795
69	Macroorchidism (HP:0000053)	1.83061156
70	Pheochromocytoma (HP:0002666)	1.82891360
71	Ventricular arrhythmia (HP:0004308)	1.82738412
72	Heterotopia (HP:0002282)	1.81141542
73	Hyperinsulinemic hypoglycemia (HP:0000825)	1.81022538
74	Hip dysplasia (HP:0001385)	1.78508758
75	Spastic gait (HP:0002064)	1.76385259
76	Dysdiadochokinesis (HP:0002075)	1.74556520
77	Protruding tongue (HP:0010808)	1.74157293
78	Thickened helices (HP:0000391)	1.72644143
79	Proximal amyotrophy (HP:0007126)	1.72161747
80	Epileptic encephalopathy (HP:0200134)	1.71838701
81	Urinary urgency (HP:0000012)	1.71623444
82	Broad-based gait (HP:0002136)	1.71262694
83	Menstrual irregularities (HP:0000858)	1.71219850
84	Oligodactyly (hands) (HP:0001180)	1.71037574
85	Absence seizures (HP:0002121)	1.70444089
86	Lower limb asymmetry (HP:0100559)	1.70132402
87	Cystic hygroma (HP:0000476)	1.68389358
88	Intestinal atresia (HP:0011100)	1.67970656
89	Germ cell neoplasia (HP:0100728)	1.67352531
90	Osteomalacia (HP:0002749)	1.65316127
91	Chronic hepatic failure (HP:0100626)	1.64687084
92	Primary atrial arrhythmia (HP:0001692)	1.63498265
93	Abnormal EKG (HP:0003115)	1.62635603
94	Ankle clonus (HP:0011448)	1.62446492
95	Long clavicles (HP:0000890)	1.61059297
96	Transitional cell carcinoma of the bladder (HP:0006740)	1.60040959
97	Fair hair (HP:0002286)	1.59623646
98	Vertebral arch anomaly (HP:0008438)	1.58562106
99	Heart block (HP:0012722)	1.58326868
100	Childhood onset (HP:0011463)	1.57756473

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	OBSCN	3.15029177
2	MARK1	3.01827928
3	CASK	2.84710334
4	PNCK	2.45240461
5	SGK2	2.45045661
6	TNIK	2.38785318
7	AKT3	2.33351886
8	FRK	2.23690679
9	SGK3	2.02897462
10	CAMK1G	2.01990953
11	NTRK3	2.01379475
12	DMPK	1.91057376
13	EPHA4	1.90654211
14	NLK	1.89672538
15	ACVR1B	1.86619350
16	SGK494	1.71709472
17	SGK223	1.71709472
18	MAP3K4	1.66533141
19	MAP3K2	1.62830576
20	PAK3	1.58445233
21	PHKG2	1.57000379
22	PHKG1	1.57000379
23	KSR1	1.55839363
24	MAP2K4	1.49146618
25	YES1	1.48212065
26	EPHA3	1.45179687
27	PINK1	1.44535900
28	WNK3	1.38860873
29	DAPK2	1.37244552
30	BRD4	1.35308800
31	MAPK13	1.29021329
32	FGFR3	1.28464661
33	FGFR2	1.27100875
34	WNK1	1.23703717
35	STK38L	1.19878213
36	CAMK1D	1.19521123
37	KSR2	1.10164016
38	STK11	1.09517773
39	ERBB3	1.09198694
40	MAP3K7	1.06641209
41	PLK2	0.91732900
42	SGK1	0.89700696
43	STK38	0.87712809
44	PIK3CG	0.86660460
45	UHMK1	0.86048869
46	PRKAA2	0.82210146
47	TTN	0.82087590
48	STK24	0.80090064
49	DYRK1A	0.79706137
50	TAOK1	0.79123265
51	MAP3K9	0.78843035
52	RAF1	0.77978665
53	PTK2B	0.75847261
54	NTRK2	0.75285445
55	PAK6	0.74723212
56	MARK2	0.74306684
57	RET	0.73126927
58	CAMK4	0.71908494
59	ROCK2	0.71373404
60	LATS1	0.69861049
61	CDK5	0.69831352
62	EPHB1	0.66992341
63	MINK1	0.66504004
64	IRAK1	0.64461579
65	CAMK1	0.62872032
66	RPS6KB1	0.62566269
67	PRKAA1	0.61157165
68	FGR	0.60317176
69	PRKG1	0.56928644
70	FER	0.56882333
71	BCR	0.56811091
72	MAP3K5	0.55615893
73	TRPM7	0.55086229
74	MAP3K6	0.55043121
75	PRKCE	0.54972571
76	PRKCH	0.54344014
77	PIK3CA	0.53749101
78	ROCK1	0.53546827
79	PDGFRB	0.51612111
80	MAP3K1	0.50328110
81	MAPK10	0.49811528
82	MAP2K7	0.47043172
83	NEK9	0.45819093
84	MKNK2	0.44451406
85	CAMK2A	0.44250362
86	OXSR1	0.44012148
87	IRAK2	0.42613994
88	CAMK2D	0.42149859
89	PRKCZ	0.40099177
90	CAMKK2	0.40037253
91	PRKD3	0.39052011
92	JAK2	0.38707572
93	FGFR1	0.37019565
94	STK39	0.36534701
95	MAP2K1	0.36025797
96	PRKCG	0.35850880
97	RIPK4	0.35567296
98	STK3	0.34296863
99	TRIM28	0.33324743
100	BMPR1B	0.32774644

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Circadian rhythm_Homo sapiens_hsa04710	1.88480306
2	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.76597412
3	Long-term potentiation_Homo sapiens_hsa04720	1.64988473
4	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.64296884
5	Insulin secretion_Homo sapiens_hsa04911	1.58529326
6	Nicotine addiction_Homo sapiens_hsa05033	1.52781418
7	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.46464583
8	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.45044923
9	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.42468391
10	Circadian entrainment_Homo sapiens_hsa04713	1.41410674
11	Long-term depression_Homo sapiens_hsa04730	1.38546882
12	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.38026984
13	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.30920187
14	Endometrial cancer_Homo sapiens_hsa05213	1.30292658
15	Amphetamine addiction_Homo sapiens_hsa05031	1.25979564
16	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.25674777
17	Dopaminergic synapse_Homo sapiens_hsa04728	1.25522402
18	Renin secretion_Homo sapiens_hsa04924	1.24419090
19	Type II diabetes mellitus_Homo sapiens_hsa04930	1.24315801
20	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.20932558
21	cAMP signaling pathway_Homo sapiens_hsa04024	1.19868635
22	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.18495166
23	Glutamatergic synapse_Homo sapiens_hsa04724	1.17386061
24	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.16939840
25	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.13015086
26	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.11979335
27	FoxO signaling pathway_Homo sapiens_hsa04068	1.11388287
28	Cholinergic synapse_Homo sapiens_hsa04725	1.09617629
29	mTOR signaling pathway_Homo sapiens_hsa04150	1.09384261
30	GnRH signaling pathway_Homo sapiens_hsa04912	1.07551582
31	GABAergic synapse_Homo sapiens_hsa04727	1.06493498
32	Gastric acid secretion_Homo sapiens_hsa04971	1.04318621
33	Glucagon signaling pathway_Homo sapiens_hsa04922	1.00726906
34	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.00011473
35	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.99922680
36	Insulin signaling pathway_Homo sapiens_hsa04910	0.99307294
37	Glioma_Homo sapiens_hsa05214	0.98695095
38	Cocaine addiction_Homo sapiens_hsa05030	0.98366167
39	Renal cell carcinoma_Homo sapiens_hsa05211	0.95730952
40	Adherens junction_Homo sapiens_hsa04520	0.95476060
41	Choline metabolism in cancer_Homo sapiens_hsa05231	0.94562950
42	Salivary secretion_Homo sapiens_hsa04970	0.94257848
43	Insulin resistance_Homo sapiens_hsa04931	0.93467580
44	Tight junction_Homo sapiens_hsa04530	0.93394211
45	Prolactin signaling pathway_Homo sapiens_hsa04917	0.92785869
46	Estrogen signaling pathway_Homo sapiens_hsa04915	0.91990688
47	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.91946034
48	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.91544008
49	AMPK signaling pathway_Homo sapiens_hsa04152	0.91221307
50	Regulation of autophagy_Homo sapiens_hsa04140	0.90194422
51	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.89991628
52	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.89965457
53	ErbB signaling pathway_Homo sapiens_hsa04012	0.88181693
54	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.87464423
55	Calcium signaling pathway_Homo sapiens_hsa04020	0.86987097
56	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.85161115
57	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.83481149
58	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.83319841
59	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.82898398
60	Morphine addiction_Homo sapiens_hsa05032	0.82428475
61	Axon guidance_Homo sapiens_hsa04360	0.82197199
62	Gap junction_Homo sapiens_hsa04540	0.81306956
63	Non-small cell lung cancer_Homo sapiens_hsa05223	0.80675426
64	Melanogenesis_Homo sapiens_hsa04916	0.79369922
65	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.75534793
66	Serotonergic synapse_Homo sapiens_hsa04726	0.74753746
67	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.74601900
68	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.74502751
69	Prostate cancer_Homo sapiens_hsa05215	0.73260775
70	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.72806201
71	Propanoate metabolism_Homo sapiens_hsa00640	0.70984758
72	Colorectal cancer_Homo sapiens_hsa05210	0.70142941
73	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.67601332
74	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.67021341
75	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.66266299
76	Rap1 signaling pathway_Homo sapiens_hsa04015	0.66169966
77	Fatty acid degradation_Homo sapiens_hsa00071	0.63912469
78	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.63588152
79	PPAR signaling pathway_Homo sapiens_hsa03320	0.62777890
80	Bile secretion_Homo sapiens_hsa04976	0.61068955
81	Histidine metabolism_Homo sapiens_hsa00340	0.60643968
82	Wnt signaling pathway_Homo sapiens_hsa04310	0.59849036
83	Pancreatic secretion_Homo sapiens_hsa04972	0.58595961
84	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.58443809
85	Lysine degradation_Homo sapiens_hsa00310	0.57728162
86	MAPK signaling pathway_Homo sapiens_hsa04010	0.57010737
87	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.56938581
88	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.56790796
89	Fatty acid metabolism_Homo sapiens_hsa01212	0.55501056
90	Proteoglycans in cancer_Homo sapiens_hsa05205	0.54307340
91	Amoebiasis_Homo sapiens_hsa05146	0.53990498
92	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.53151406
93	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.53021644
94	beta-Alanine metabolism_Homo sapiens_hsa00410	0.51732684
95	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.51667384
96	Butanoate metabolism_Homo sapiens_hsa00650	0.51570796
97	Platelet activation_Homo sapiens_hsa04611	0.51458042
98	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.50090192
99	Ras signaling pathway_Homo sapiens_hsa04014	0.50044659
100	Pancreatic cancer_Homo sapiens_hsa05212	0.49162808

KIAA0232

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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